Phillip Wilmarth

Research Assistant Professor

  • 2329 Citations
  • 27 h-Index
1981 …2019
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Research Output 1981 2019

  • 2329 Citations
  • 27 h-Index
  • 91 Article
  • 1 Chapter
2019

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

Abdelhamed, S., Butler, J. T., Doron, B., Halse, A., Nemecek, E., Wilmarth, P., Marks, D., Chang, B., Horton, T. & Kurre, P., Jul 1 2019, In : EMBO Reports. 20, 7, e47546.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Acute Myeloid Leukemia
DNA
DNA Damage

Identification of PKCα-dependent phosphoproteins in mouse retina

Wakeham, C. M., Wilmarth, P., Cunliffe, J. M., Klimek, J. E., Ren, G., David, L. & Morgans, C., Aug 30 2019, In : Journal of Proteomics. 206, 103423.

Research output: Contribution to journalArticle

Protein Kinase C-alpha
Phosphoproteins
Retina
Phosphorylation
Cell Physiological Phenomena
4 Citations (Scopus)

Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers

Zhao, Y., Wilmarth, P., Cheng, C., Limi, S., Fowler, V. M., Zheng, D., David, L. & Cvekl, A., Feb 1 2019, In : Experimental Eye Research. 179, p. 32-46 15 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Proteome
Lenses
Epithelium
Proteins
2018
1 Citation (Scopus)
Angiogenic Proteins
Retinal Vessels
Proteomics
Endothelial Cells
Pharmaceutical Preparations
2 Citations (Scopus)

Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

Vranka, J., Staverosky, J., Reddy, A. P., Wilmarth, P., David, L., Acott, T., Russell, P. & Raghunathan, V. K., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 246-259 14 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Proteomics
Pressure
Elastic Modulus
Extracellular Matrix Proteins
4 Citations (Scopus)

Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Hulett, T. W., Jensen, S. M., Wilmarth, P., Reddy, A. P., Ballesteros-Merino, C., Afentoulis, M. E., Dubay, C., David, L. & Fox, B. A., Apr 5 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 27.

Research output: Contribution to journalArticle

Neoplasm Antigens
Vaccination
Immunoglobulin G
T-Lymphocytes
Antibodies
3 Citations (Scopus)

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells

Krey, J. F., Dumont, R. A., Wilmarth, P., David, L., Johnson, K. R. & Barr-Gillespie, P., Jan 24 2018, In : Journal of Neuroscience. 38, 4, p. 843-857 15 p.

Research output: Contribution to journalArticle

Vestibular Hair Cells
Guanosine Triphosphate
Hydrolysis
ADP-Ribosylation Factors
Saccule and Utricle

GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate

Plubell, D. L., Fenton, A. M., Wilmarth, P., Bergstrom, P., Zhao, Y., Minnier, J., Heinecke, J. W., Yang, X. & Pamir, N., Dec 1 2018, In : Scientific Reports. 8, 1, 11485.

Research output: Contribution to journalArticle

Myeloid Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Weight Gain
Insulin Resistance
Adipose Tissue
5 Citations (Scopus)

MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection

Rozanov, D., Rozanov, N. D., Chiotti, K. E., Reddy, A., Wilmarth, P., David, L., Cha, S. W., Woo, S., Pevzner, P., Bafna, V., Burrows, G. G., Rantala, J. K., Levin, T., Anur, P., Johnson-Camacho, K., Tabatabaei, S., Munson, D. J., Bruno, T. C., Slansky, J. E., Kappler, J. W. & 9 others, Hirano, N., Boegel, S., Fox, B. A., Egelston, C., Simons, D. L., Jimenez, G., Lee, P. P., Gray, J. & Spellman, P., Mar 30 2018, In : Journal of Proteomics. 176, p. 13-23 11 p.

Research output: Contribution to journalArticle

Cells
Breast Neoplasms
Ligands
Cell Line
Peptides
2017
2 Citations (Scopus)

Analysis of the Proteome of Hair-Cell Stereocilia by Mass Spectrometry

Krey, J. F., Wilmarth, P., David, L. & Barr-Gillespie, P., 2017, Methods in Enzymology. Academic Press Inc., Vol. 585. p. 329-354 26 p. (Methods in Enzymology; vol. 585).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stereocilia
Proteome
Hair
Mass spectrometry
Mass Spectrometry
17 Citations (Scopus)

Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue

Plubell, D. L., Wilmarth, P., Zhao, Y., Fenton, A. M., Minnier, J., Reddy, A. P., Klimek, J., Yang, X., David, L. & Pamir, N., May 1 2017, In : Molecular and Cellular Proteomics. 16, 5, p. 873-890 18 p.

Research output: Contribution to journalArticle

High Fat Diet
Proteome
Nutrition
Multiplexing
Labeling
14 Citations (Scopus)

Proteomic analysis of the bovine and human ciliary zonule

De Maria, A., Wilmarth, P., David, L. & Bassnett, S., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 573-585 13 p.

Research output: Contribution to journalArticle

Proteomics
Proteins
Mass Spectrometry
Ectopia Lentis
High Pressure Liquid Chromatography
3 Citations (Scopus)
Epithelial-Mesenchymal Transition
Heat-Shock Proteins
Proteomics
Lenses
Glutathione
2016
6 Citations (Scopus)

γ-Crystallins of the chicken lens: Remnants of an ancient vertebrate gene family in birds

Chen, Y., Sagar, V., Len, H. S., Peterson, K., Fan, J., Mishra, S., Mcmurtry, J., Wilmarth, P., David, L. & Wistow, G., 2016, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Crystallins
Birds
Lenses
Vertebrates
Chickens
2015
33 Citations (Scopus)

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Exosomes
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Bone Marrow
Exosome Multienzyme Ribonuclease Complex
9 Citations (Scopus)

Hair-bundle proteomes of avian and mammalian inner-ear utricles

Wilmarth, P., Krey, J. F., Shin, J. B., Choi, D., David, L. & Barr-Gillespie, P., Dec 8 2015, In : Scientific data. 2, 150074.

Research output: Contribution to journalArticle

Bundle
Proteins
Mouse
Peptides
Rats
5 Citations (Scopus)

Role for Rab10 in methamphetamine-induced behavior

Vanderwerf, S. M., Buck, D. C., Wilmarth, P., Sears, L. M., David, L., Morton, D. & Neve, K., Aug 20 2015, In : PLoS One. 10, 8, e0136167.

Research output: Contribution to journalArticle

Methamphetamine
receptors
rats
Membranes
Rats
2 Citations (Scopus)

Solution-phase crosstalk and regulatory interactions between multipotent adult progenitor cells and peripheral blood mononuclear cells

Burrows, G. G., Hof, W. VT., Reddy, A. P., Wilmarth, P., David, L., Raber, A., Bogaerts, A., Timmerman, L., Pinxteren, J., Roobrouck, V. D., Deans, R. J. & Maziarz, R., Dec 1 2015, In : Stem cells translational medicine. 4, 12, p. 1436-1449 14 p.

Research output: Contribution to journalArticle

Blood Cells
Stem Cells
Physiological Stress
Proteins
Cyclin D1
2014
51 Citations (Scopus)

Accurate label-free protein quantitation with high- and low-resolution mass spectrometers

Krey, J. F., Wilmarth, P., Shin, J. B., Klimek, J., Sherman, N. E., Jeffery, E. D., Choi, D., David, L. & Barr-Gillespie, P., Feb 7 2014, In : Journal of Proteome Research. 13, 2, p. 1034-1044 11 p.

Research output: Contribution to journalArticle

Mass spectrometers
Labels
Ions
Proteins
Tandem Mass Spectrometry
16 Citations (Scopus)

Correlation of actin crosslinker and capper expression levels with stereocilia growth phases

Avenarius, M. R., Saylor, K. W., Lundeberg, M. R., Wilmarth, P., Shin, J. B., Spinelli, K. J., Pagana, J. M., Andrade, L., Kachar, B., Choi, D., David, L. & Barr-Gillespie, P., Feb 2014, In : Molecular and Cellular Proteomics. 13, 2, p. 606-620 15 p.

Research output: Contribution to journalArticle

Stereocilia
Actins
Cochlea
Growth
Mass spectrometry
42 Citations (Scopus)
Crystallins
Cataract
Lenses
Post Translational Protein Processing
Amides
31 Citations (Scopus)

Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani

Martin, J. L., Yates, P., Soysa, R., Alfaro, J. F., Yang, F., Burnum-Johnson, K. E., Petyuk, V. A., Weitz, K. K., Camp, D. G., Smith, R. D., Wilmarth, P., David, L., Ramasamy, G., Myler, P. J. & Carter, N., 2014, In : PLoS Pathogens. 10, 2, e1003938.

Research output: Contribution to journalArticle

Leishmania donovani
Parasites
Starvation
Proteome
purine
4 Citations (Scopus)

Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin

Shang, F., Wilmarth, P., Chang, M. L., Liu, K., David, L., Caceres, M. A., Wawrousek, E. & Taylor, A., Mar 7 2014, In : Journal of Proteome Research. 13, 3, p. 1177-1189 13 p.

Research output: Contribution to journalArticle

Proteome
Ubiquitin
Lenses
Lysine
Crystallins
8 Citations (Scopus)

Proteomic analysis of cervical vaginal fluid proteins among women in recurrent preterm labor

Lo, J., Reddy, A. P., Wilmarth, P., Roberts, V., Kinhnarath, A., Snyder, J., Rincon, M. P., Gravett, M. G., Nagalla, S. R. & Pereira, L., 2014, In : Journal of Maternal-Fetal and Neonatal Medicine. 27, 12, p. 1183-1188 6 p.

Research output: Contribution to journalArticle

Premature Obstetric Labor
Premature Birth
Proteomics
Gestational Age
Case-Control Studies
2013
16 Citations (Scopus)

Dissection of the human multipotent adult progenitor cell secretome by proteomic analysis

Burrows, G. G., Van't Hof, W., Newell, L., Reddy, A., Wilmarth, P., David, L., Raber, A., Bogaerts, A., Pinxteren, J., Deans, R. J. & Maziarz, R., Oct 2013, In : Stem cells translational medicine. 2, 10, p. 745-757 13 p.

Research output: Contribution to journalArticle

Proteomics
Dissection
Stem Cells
Extracellular Matrix Proteins
Intercellular Signaling Peptides and Proteins
79 Citations (Scopus)

Molecular architecture of the chick vestibular hair bundle

Shin, J. B., Krey, J. F., Hassan, A., Metlagel, Z., Tauscher, A. N., Pagana, J. M., Sherman, N. E., Jeffery, E. D., Spinelli, K. J., Zhao, H., Wilmarth, P., Choi, D., David, L., Auer, M. & Barr-Gillespie, P., Mar 2013, In : Nature Neuroscience. 16, 3, p. 365-374 10 p.

Research output: Contribution to journalArticle

Actins
Mass Spectrometry
Proteins
Electron Microscope Tomography
Stereocilia
58 Citations (Scopus)

Role of the retinal vascular endothelial cell in ocular disease

Bharadwaj, A. S., Appukuttan, B., Wilmarth, P., Pan, Y., Stempel, A. J., Chipps, T. J., Benedetti, E. E., Zamora, D. O., Choi, D., David, L. & Smith, J. R., Jan 2013, In : Progress in Retinal and Eye Research. 32, 1, p. 102-180 79 p.

Research output: Contribution to journalArticle

Retinal Vessels
Eye Diseases
Endothelial Cells
Retina
Endothelium
9 Citations (Scopus)

Shotgun proteomic analysis of S-thiolation sites of guinea pig lens nuclear crystallins following oxidative stress in vivo

Giblin, F. J., David, L., Wilmarth, P., Leverenz, V. R. & Simpanya, M. F., Feb 3 2013, In : Molecular Vision. 19, p. 267-280 14 p.

Research output: Contribution to journalArticle

Crystallins
Firearms
Proteomics
Lenses
Guinea Pigs
18 Citations (Scopus)

Verification and spatial localization of aquaporin-5 in the ocular lens

Grey, A. C., Walker, K. L., Petrova, R. S., Han, J., Wilmarth, P., David, L., Donaldson, P. J. & Schey, K. L., Mar 2013, In : Experimental Eye Research. 108, p. 94-102 9 p.

Research output: Contribution to journalArticle

Aquaporin 5
Crystalline Lens
Lenses
Aquaporins
Western Blotting
2012
17 Citations (Scopus)

A systems approach implicates nuclear receptor targeting in the Atp7b -/- mouse model of Wilson's disease

Wilmarth, P., Short, K. K., Fiehn, O., Lutsenko, S., David, L. & Burkhead, J. L., 2012, In : Metallomics. 4, 7, p. 660-668 9 p.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Cytoplasmic and Nuclear Receptors
Systems Analysis
Copper
Liver
19 Citations (Scopus)
Energy Metabolism
Mass Spectrometry
Epithelium
Proteins
Oxidative Phosphorylation
14 Citations (Scopus)

Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?

Truscott, R. J. W., Mizdrak, J., Friedrich, M. G., Hooi, M. Y., Lyons, B., Jamie, J. F., Davies, M. J., Wilmarth, P. & David, L., Jun 2012, In : Experimental Eye Research. 99, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Crystallins
Methylation
Lenses
Proteins
2011
18 Citations (Scopus)

Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease

Burkhead, J. L., Ralle, M., Wilmarth, P., David, L. & Lutsenko, S., Feb 11 2011, In : Journal of Molecular Biology. 406, 1, p. 44-58 15 p.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Copper
RNA
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Liver
14 Citations (Scopus)

Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure

Moore, R. A., Timmes, A. G., Wilmarth, P., Safronetz, D. & Priola, S. A., Oct 2011, In : Proteomics. 11, 19, p. 3853-3865 13 p.

Research output: Contribution to journalArticle

Fourier Transform Infrared Spectroscopy
Proteins
Prions
Ferritins
Conformations
35 Citations (Scopus)

Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity

Yang, Y., Dai, M., Wilson, T. M., Omelchenko, I., Klimek, J. E., Wilmarth, P., David, L., Nuttall, A., Barr-Gillespie, P. & Shi, X., 2011, In : PLoS One. 6, 1, e16547.

Research output: Contribution to journalArticle

sodium-potassium-exchanging ATPase
Inner Ear
blood proteins
Adenosine Triphosphatases
Blood Proteins
16 Citations (Scopus)
Protein Databases
Proteomics
Databases
Chemical analysis
Proteins
2010
24 Citations (Scopus)

Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations

Moore, R. A., Timmes, A., Wilmarth, P. & Priola, S. A., Aug 2010, In : Proteomics. 10, 15, p. 2858-2869 12 p.

Research output: Contribution to journalArticle

Scrapie
Prion Diseases
Proteins
Prions
Ferritins
74 Citations (Scopus)

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

Shin, J. B., Longo-Guess, C. M., Gagnon, L. H., Saylor, K. W., Dumont, R. A., Spinelli, K. J., Pagana, J. M., Wilmarth, P., David, L., Barr-Gillespie, P. & Johnson, K. R., Jul 21 2010, In : Journal of Neuroscience. 30, 29, p. 9683-9694 12 p.

Research output: Contribution to journalArticle

Stereocilia
Inbred DBA Mouse
Hearing Loss
Hair
Actins
2009
30 Citations (Scopus)

Quantification of isotopically overlapping deamidated and 18O-labeled peptides using isotopic Envelope mixture modeling

Dasari, S., Wilmarth, P., Reddy, A. P., Robertson, L. J. G., Nagalla, S. R. & David, L., Mar 6 2009, In : Journal of Proteome Research. 8, 3, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

Peptides
Lenses
Crystallins
Workflow
Water
47 Citations (Scopus)
Crystallins
Firearms
Proteomics
Protein Databases
Lenses
74 Citations (Scopus)

The membrane proteome of the mouse lens fiber cell.

Bassnett, S., Wilmarth, P. & David, L., 2009, In : Molecular Vision. 15, p. 2448-2463 16 p.

Research output: Contribution to journalArticle

Proteome
Lenses
Membranes
Cell Membrane
Membrane Proteins
2008
45 Citations (Scopus)

Accurate annotation of peptide modifications through unrestrictive database search

Tanner, S., Payne, S. H., Dasari, S., Shen, Z., Wilmarth, P., David, L., Loomis, W. F., Briggs, S. P. & Bafna, V., Jan 2008, In : Journal of Proteome Research. 7, 1, p. 170-181 12 p.

Research output: Contribution to journalArticle

Signal transduction
Post Translational Protein Processing
Polymorphism
Mass spectrometry
Databases
14 Citations (Scopus)

Tissue transglutaminase catalyzes the deamidation of glutamines in lens βB2- and βB3-crystallins

Boros, S., Wilmarth, P., Kamps, B., de Jong, W. W., Bloemendal, H., Lampi, K. & Boelens, W. C., Feb 2008, In : Experimental Eye Research. 86, 2, p. 383-393 11 p.

Research output: Contribution to journalArticle

Crystallins
Glutamine
Lenses
transglutaminase 2
Electrophoresis, Gel, Two-Dimensional
2007
22 Citations (Scopus)

Biophysical Properties of γC-Crystallin in Human and Mouse Eye Lens: The Role of Molecular Dipoles

Purkiss, A. G., Bateman, O. A., Wyatt, K., Wilmarth, P., David, L., Wistow, G. J. & Slingsby, C., Sep 7 2007, In : Journal of Molecular Biology. 372, 1, p. 205-222 18 p.

Research output: Contribution to journalArticle

Crystalline Lens
Crystallins
Solubility
Lenses
Cysteine
27 Citations (Scopus)

Reliable detection of deamidated peptides from lens crystallin proteins using changes in reversed-phase elution times and parent ion masses

Dasari, S., Wilmarth, P., Rustvold, D. L., Riviere, M. A., Nagalla, S. R. & David, L., Sep 2007, In : Journal of Proteome Research. 6, 9, p. 3819-3826 8 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Ions
Peptides
Proteins
2006
178 Citations (Scopus)

Age-related changes in human crystalline determined from comparative analysis of post-translational modifications in young and aged lens: Does deamidation contribute to crystallin insolubility?

Wilmarth, P., Tanner, S., Dasari, S., Nagalla, S. R., Riviere, M. A., Bafha, V., Pevzner, P. A. & David, L., Oct 2006, In : Journal of Proteome Research. 5, 10, p. 2554-2566 13 p.

Research output: Contribution to journalArticle

Crystallins
Post Translational Protein Processing
Lenses
Solubility
Crystalline materials
2005
92 Citations (Scopus)

Identification of protein modifications using MS/MS de novo sequencing and the OpenSea alignment algorithm

Searle, B. C., Dasari, S., Wilmarth, P., Turner, M., Reddy, A. P., David, L. & Nagalla, S. R., Mar 2005, In : Journal of Proteome Research. 4, 2, p. 546-554 9 p.

Research output: Contribution to journalArticle

Lenses
Proteins
Data Mining
Sequence Alignment
Post Translational Protein Processing
2004
122 Citations (Scopus)

High-Throughput Identification of Proteins and Unanticipated Sequence Modifications Using a Mass-Based Alignment Algorithm for MS/MS de Novo Sequencing Results

Searle, B. O., Dasari, S., Turner, M., Reddy, A. P., Choi, D., Wilmarth, P., McCormack, A. L., David, L. & Nagalla, S. B., Apr 15 2004, In : Analytical Chemistry. 76, 8, p. 2220-2230 11 p.

Research output: Contribution to journalArticle

Throughput
Proteins
Amino Acids
Peptides
Mass spectrometry
30 Citations (Scopus)

Laser light-scattering evidence for an altered association of βB1-crystallin deamidated in the connecting peptide

Harms, M. J., Wilmarth, P., Kapfer, D. M., Steel, E. A., David, L., Bächinger, H. P. & Lampi, K., Mar 2004, In : Protein Science. 13, 3, p. 678-686 9 p.

Research output: Contribution to journalArticle

Crystallins
C-Peptide
Light scattering
Lasers
Light
31 Citations (Scopus)

Proteomic and sequence analysis of chicken lens crystallins reveals alternate splicing and translational forms of βB2 and βA2 crystallins

Wilmarth, P., Taube, J. R., Riviere, M. A., Duncan, M. K. & David, L., Aug 2004, In : Investigative Ophthalmology and Visual Science. 45, 8, p. 2705-2715 11 p.

Research output: Contribution to journalArticle

Crystallins
Alternative Splicing
varespladib methyl
Proteomics
Lenses