Philip Stork

Professor

  • 8982 Citations
  • 45 h-Index
1976 …2018

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2018

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect

Rauen, K. A., Schoyer, L., Schill, L., Stronach, B., Albeck, J., Andresen, B. S., Cavé, H., Ellis, M., Fruchtman, S. M., Gelb, B. D., Gibson, C. C., Gripp, K., Hefner, E., Huang, W. Y. C., Itkin, M., Kerr, B., Linardic, C. M., McMahon, M., Oberlander, B., Perlstein, E. & 17 others, Ratner, N., Rogers, L., Schenck, A., Shankar, S., Shvartsman, S., Stevenson, D. A., Stites, E. C., Stork, P., Sun, C., Therrien, M., Ullian, E. M., Widemann, B. C., Yeh, E., Zampino, G., Zenker, M., Timmer, W. & McCormick, F., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A. e40632.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P. J. S., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Tillo, S. E., Xiong, W-H., Takahashi, M., Miao, S., Andrade, A. L., Fortin, D. A., Yang, G., Qin, M., Smoody, B. F., Stork, P. & Zhong, H., Apr 18 2017, In : Cell Reports. 19, 3, p. 617-629 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP

Takahashi, M., Li, Y., Dillon, T. J. & Stork, P., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1449-1461 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phosphorylation of the C-Raf N region promotes Raf dimerization

Takahashi, M., Li, Y., Dillon, T. J., Kariya, Y. & Stork, P., Oct 1 2017, In : Molecular and Cellular Biology. 37, 19, e00132-17.

Research output: Contribution to journalArticle

5 Scopus citations
2016

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells

Obara, Y., Nagasawa, R., Nemoto, W., Pellegrino, M. J., Takahashi, M., Habecker, B. A., Stork, P. J. S., Ichiyanagi, O., Ito, H., Tomita, Y., Ishii, K. & Nakahata, N., Mar 1 2016, In : Cellular Signalling. 28, 3, p. 177-189 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Protein kinase A-independent Ras protein activation cooperates with Rap1 protein to mediate activation of the extracellular signal-regulated kinases (ERK) by cAMP

Li, Y., Dillon, T. J., Takahashi, M., Earley, K. T. & Stork, P., Oct 7 2016, In : Journal of Biological Chemistry. 291, 41, p. 21584-21595 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014
13 Scopus citations
2013

Allosteric activation of functionally asymmetric RAF kinase dimers

Hu, J., Stites, E. C., Yu, H., Germino, E. A., Meharena, H. S., Stork, P. J. S., Kornev, A. P., Taylor, S. S. & Shaw, A. S., Aug 29 2013, In : Cell. 154, 5, p. 1036-1046 11 p.

Research output: Contribution to journalArticle

140 Scopus citations

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

Dillon, T. J., Takahashi, M., Li, Y., Tavisala, S., Murray, S. E., Moran, A. E., Parker, D. C. & Stork, P. J. S., Apr 1 2013, In : International Immunology. 25, 4, p. 259-269 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

Wang, Z., Liu, Y., Takahashi, M., Van Hook, K., Kampa-Schittenhelm, K. M., Sheppard, B. C., Sears, R. C., Stork, P. J. S. & Lopez, C. D., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 312-317 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Protein kinase a-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration

Takahashi, M., Dillon, T. J., Liu, C., Kariya, Y., Wang, Z. & Stork, P. J. S., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 27712-27723 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
16 Scopus citations
2012
17 Scopus citations

Thyroid hormone drives fetal cardiomyocyte maturation

Chattergoon, N. N., Giraud, G. D., Louey, S., Stork, P., Fowden, A. L. & Thornburg, K. L., Jan 1 2012, In : FASEB Journal. 26, 1, p. 397-408 12 p.

Research output: Contribution to journalArticle

81 Scopus citations
2010

The interaction of Epac1 and ran promotes Rap1 activation at the nuclear envelope

Liu, C., Takahashi, M., Li, Y., Dillon, T. J., Kaech, S. & Stork, P. J. S., Aug 1 2010, In : Molecular and cellular biology. 30, 16, p. 3956-3969 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2009

ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells

Obara, Y., Yamauchi, A., Takehara, S., Nemoto, W., Takahashi, M., Stork, P. J. S. & Nakahata, N., Aug 28 2009, In : Journal of Biological Chemistry. 284, 35, p. 23564-23573 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2008

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

Liu, C., Takahashi, M., Li, Y., Song, S., Dillon, T. J., Shinde, U. & Stork, P. J. S., Dec 1 2008, In : Molecular and cellular biology. 28, 23, p. 7109-7125 17 p.

Research output: Contribution to journalArticle

41 Scopus citations
2007

Putting on the RITz.

Kaech, S., Banker, G. & Stork, P., Dec 11 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 416, p. pe71

Research output: Contribution to journalArticle

2 Scopus citations

The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells

Obara, Y., Horgan, A. M. & Stork, P. J. S., Apr 1 2007, In : Journal of neurochemistry. 101, 2, p. 470-482 13 p.

Research output: Contribution to journalArticle

45 Scopus citations
2006

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

Wang, Z., Dillon, T. J., Pokala, V., Mishra, S., Labudda, K., Hunter, B. & Stork, P. J. S., Mar 1 2006, In : Molecular and cellular biology. 26, 6, p. 2130-2145 16 p.

Research output: Contribution to journalArticle

126 Scopus citations
42 Scopus citations
2005

Directing NGF's actions: It's a rap

Stork, P. J., Apr 1 2005, In : Nature Cell Biology. 7, 4, p. 338-339 2 p.

Research output: Contribution to journalArticle

20 Scopus citations

Ras-independent activation of ERK signaling via the Torso receptor tyrosine kinase is mediated by Rap1

Mishra, S., Smolik, S. M., Forte, M. A. & Stork, P. J. S., Feb 22 2005, In : Current Biology. 15, 4, p. 366-370 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4

Dillon, T. J., Carey, K. D., Wetzel, S. A., Parker, D. C. & Stork, P. J. S., May 1 2005, In : Molecular and cellular biology. 25, 10, p. 4117-4128 12 p.

Research output: Contribution to journalArticle

42 Scopus citations
2004

PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells

Obara, Y., Labudda, K., Dillon, T. J. & Stork, P. J. S., Dec 1 2004, In : Journal of Cell Science. 117, 25, p. 6085-6094 10 p.

Research output: Contribution to journalArticle

104 Scopus citations
2003

Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy

Dillon, T. J., Karpitski, V., Wetzel, S. A., Parker, D. C., Shaw, A. S. & Stork, P. J. S., Sep 19 2003, In : Journal of Biological Chemistry. 278, 38, p. 35940-35949 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Examining the mechanism of Erk nuclear translocation using green fluorescent protein

Horgan, A. M. & Stork, P. J. S., May 1 2003, In : Experimental Cell Research. 285, 2, p. 208-220 13 p.

Research output: Contribution to journalArticle

51 Scopus citations
91 Scopus citations

The requirement of specific membrane domains for Raf-1 phosphorylation and activation

Carey, K. D., Watson, R. T., Pessin, J. E. & Stork, P. J. S., Jan 31 2003, In : Journal of Biological Chemistry. 278, 5, p. 3185-3196 12 p.

Research output: Contribution to journalArticle

41 Scopus citations
2002

ERK signaling: duration, duration, duration.

Stork, P. J. S., Jan 1 2002, In : Cell cycle (Georgetown, Tex.). 1, 5, p. 315-317 3 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Gα and Gβγ require distinct Src-dependent pathways to activate Rap1 and Ras

Schmitt, J. M. & Stork, P. J. S., Nov 8 2002, In : Journal of Biological Chemistry. 277, 45, p. 43024-43032 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1

Schmitt, J. M. & Stork, P. J. S., Jan 1 2002, In : Molecular Cell. 9, 1, p. 85-94 10 p.

Research output: Contribution to journalArticle

199 Scopus citations
2001

Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1

Schmitt, J. M. & Stork, P. J. S., Jun 1 2001, In : Molecular and cellular biology. 21, 11, p. 3671-3683 13 p.

Research output: Contribution to journalArticle

112 Scopus citations

Hormonal control of insulin-like growth factor I gene transcription in human osteoblasts: Dual actions of cAMP-dependent protein kinase on CCAAT/enhancer-binding protein δ

Billiard, J., Grewal, S. S., Lukaesko, L., Stork, P. J. S. & Rotwein, P., Aug 17 2001, In : Journal of Biological Chemistry. 276, 33, p. 31238-31246 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2000

Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap-1-extracellular signal-regulated kinase pathway

Grewal, S. S., Fass, D. M., Yao, H., Ellig, C. L., Goodman, R. H. & Stork, P. J. S., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34433-34441 9 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

CD28 and the tyrosine kinase Lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1

Carey, K. D., Dillon, T. J., Schmitt, J. M., Baird, A. M., Holdorf, A. D., Straus, D. B., Shaw, A. S. & Stork, P. J. S., Nov 11 2000, In : Molecular and cellular biology. 20, 22, p. 8409-8419 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase

Grewal, S. S., Horgan, A. M., York, R. D., Withers, G. S., Banker, G. A. & Stork, P. J. S., Feb 4 2000, In : Journal of Biological Chemistry. 275, 5, p. 3722-3728 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1

York, R. D., Molliver, D. C., Grewal, S. S., Stenberg, P. E., McCleskey, E. W. & Stork, P. J. S., Jan 1 2000, In : Molecular and cellular biology. 20, 21, p. 8069-8083 15 p.

Research output: Contribution to journalArticle

195 Scopus citations

Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: Role of the phosphotyrosine phosphatase SHP-2

Florio, T., Thellung, S., Arena, S., Corsaro, A., Bajetto, A., Schettini, G. & Stork, P. J. S., Jan 1 2000, In : Journal of Physiology Paris. 94, 3-4, p. 239-250 12 p.

Research output: Contribution to journalArticle

61 Scopus citations
150 Scopus citations
1999

Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells

Chen, T., Cho, R. W., Stork, P. J. S. & Weber, M. J., Jan 1 1999, In : Cancer Research. 59, 1, p. 213-218 6 p.

Research output: Contribution to journalArticle

91 Scopus citations
80 Scopus citations
117 Scopus citations

Modulation of Rap activity by direct interaction of Gα(o) with rap1 GTPase-activating protein

Jordan, J. D., Carey, K. D., Stork, P. J. S. & Iyengar, R., Jul 30 1999, In : Journal of Biological Chemistry. 274, 31, p. 21507-21510 4 p.

Research output: Contribution to journalArticle

132 Scopus citations

Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1)

Florio, T., Yao, H., Carey, K. D., Dillon, T. J. & Stork, P. J. S., Jan 1 1999, In : Molecular Endocrinology. 13, 1, p. 24-37 14 p.

Research output: Contribution to journalArticle

Open Access
120 Scopus citations
1998

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

York, R. D., Yao, H., Dillon, T., Ellig, C. L., Eckert, S. P., McCleskey, E. W. & Stork, P. J. S., Apr 9 1998, In : Nature. 392, 6676, p. 622-626 5 p.

Research output: Contribution to journalArticle

731 Scopus citations
1997

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

Vossler, M. R., Yao, H., York, R. D., Pan, M. G., Rim, C. S. & Stork, P. J. S., Apr 4 1997, In : Cell. 89, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

Open Access
914 Scopus citations

Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis

Magi-Galluzzi, C., Mishra, R., Fiorentino, M., Montironi, R., Yao, H., Capodieci, P., Wishnow, K., Kaplan, I., Stork, P. J. S. & Loda, M., Jan 1 1997, In : Laboratory Investigation. 76, 1, p. 37-51 15 p.

Research output: Contribution to journalArticle

148 Scopus citations

Mitogen-activated protein kinase phosphatases inactivate stress- activated protein kinase pathways in vivo

Hirsch, D. D. & Stork, P. J. S., Feb 25 1997, In : Journal of Biological Chemistry. 272, 7, p. 4568-4575 8 p.

Research output: Contribution to journalArticle

110 Scopus citations