Philip Stork

Professor

  • 8796 Citations
  • 45 h-Index
1976 …2018
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Research Output 1976 2018

  • 8796 Citations
  • 45 h-Index
  • 89 Article
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Article
2018

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect

Rauen, K. A., Schoyer, L., Schill, L., Stronach, B., Albeck, J., Andresen, B. S., Cavé, H., Ellis, M., Fruchtman, S. M., Gelb, B. D., Gibson, C. C., Gripp, K., Hefner, E., Huang, W. Y. C., Itkin, M., Kerr, B., Linardic, C. M., McMahon, M., Oberlander, B., Perlstein, E. & 17 others, Ratner, N., Rogers, L., Schenck, A., Shankar, S., Shvartsman, S., Stevenson, D. A., Stites, E. C., Stork, P., Sun, C., Therrien, M., Ullian, E. M., Widemann, B. C., Yeh, E., Zampino, G., Zenker, M., Timmer, W. & McCormick, F., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A. e40632.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Neoplasms
Musculoskeletal Abnormalities
Skin Abnormalities
Eye Abnormalities
2017
1 Citation (Scopus)

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

Ligases
Biotin
ras Proteins
Cells
Prenylation
9 Citations (Scopus)

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Tillo, S. E., Xiong, W-H., Takahashi, M., Miao, S., Andrade, A. L., Fortin, D. A., Yang, G., Qin, M., Smoody, B. F., Stork, P. & Zhong, H., Apr 18 2017, In : Cell Reports. 19, 3, p. 617-629 13 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Catalytic Domain
Membranes
Substrates
Protein Kinase C
10 Citations (Scopus)

Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP

Takahashi, M., Li, Y., Dillon, T. J. & Stork, P., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1449-1461 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Chemical activation
3 Citations (Scopus)

Phosphorylation of the C-Raf N region promotes Raf dimerization

Takahashi, M., Li, Y., Dillon, T. J., Kariya, Y. & Stork, P., Oct 1 2017, In : Molecular and Cellular Biology. 37, 19, e00132-17.

Research output: Contribution to journalArticle

Dimerization
Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Serine
Tyrosine
2016
3 Citations (Scopus)

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells

Obara, Y., Nagasawa, R., Nemoto, W., Pellegrino, M. J., Takahashi, M., Habecker, B., Stork, P., Ichiyanagi, O., Ito, H., Tomita, Y., Ishii, K. & Nakahata, N., Mar 1 2016, In : Cellular Signalling. 28, 3, p. 177-189 13 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Tyrosine 3-Monooxygenase
Catecholamines
Homeostasis
Pheochromocytoma
8 Citations (Scopus)

Protein kinase A-independent Ras protein activation cooperates with Rap1 protein to mediate activation of the extracellular signal-regulated kinases (ERK) by cAMP

Li, Y., Dillon, T. J., Takahashi, M., Earley, K. T. & Stork, P., Oct 7 2016, In : Journal of Biological Chemistry. 291, 41, p. 21584-21595 12 p.

Research output: Contribution to journalArticle

ras Proteins
Extracellular Signal-Regulated MAP Kinases
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Chemical activation
2014
13 Citations (Scopus)
Phosphatidylinositol 3-Kinases
Cardiac Myocytes
Somatomedins
Sheep
Phosphorylation
2013
125 Citations (Scopus)

Allosteric activation of functionally asymmetric RAF kinase dimers

Hu, J., Stites, E. C., Yu, H., Germino, E. A., Meharena, H. S., Stork, P., Kornev, A. P., Taylor, S. S. & Shaw, A. S., Aug 29 2013, In : Cell. 154, 5, p. 1036-1046 11 p.

Research output: Contribution to journalArticle

Dimers
Phosphotransferases
Chemical activation
Phosphorylation
Dimerization
2 Citations (Scopus)

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

Dillon, T. J., Takahashi, M., Li, Y., Tavisala, S., Murray, S., Moran, A., Parker, D. & Stork, P., Apr 2013, In : International Immunology. 25, 4, p. 259-269 11 p.

Research output: Contribution to journalArticle

Thymocytes
raf Kinases
MAP Kinase Signaling System
T-Cell Antigen Receptor
Thymus Gland
35 Citations (Scopus)

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

Wang, Z., Liu, Y., Takahashi, M., Van Hook, K., Kampa-Schittenhelm, K. M., Sheppard, B., Sears, R., Stork, P. & Lopez, C., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 312-317 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Guanosine Triphosphate
Oncogenes
ras Proteins
Neoplasms
25 Citations (Scopus)

Protein kinase a-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration

Takahashi, M., Dillon, T. J., Liu, C., Kariya, Y., Wang, Z. & Stork, P., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 27712-27723 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinases
Cell Movement
Monomeric GTP-Binding Proteins
Membranes
16 Citations (Scopus)
Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Protein Kinases
Chemical activation
Cells
2012
16 Citations (Scopus)
Thyroid Hormones
Cardiac Myocytes
Sheep
Pregnancy
Thyronines
69 Citations (Scopus)

Thyroid hormone drives fetal cardiomyocyte maturation

Chattergoon, N., Giraud, G., Louey, S., Stork, P., Fowden, A. L. & Thornburg, K., Jan 2012, In : FASEB Journal. 26, 1, p. 397-408 12 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Cardiac Myocytes
Cyclin D1
Cells
Thyronines
2010
33 Citations (Scopus)

The interaction of Epac1 and ran promotes Rap1 activation at the nuclear envelope

Liu, C., Takahashi, M., Li, Y., Dillon, T. J., Kaech-Petrie, S. & Stork, P., Aug 2010, In : Molecular and Cellular Biology. 30, 16, p. 3956-3969 14 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Cyclic AMP
Nuclear Pore
Monomeric GTP-Binding Proteins
ras Proteins
2009
3 Citations (Scopus)

CAMP signaling for ERK activation in neuronal cells

Obara, Y., Nakahata, N. & Stork, P., 2009, In : Folia Pharmacologica Japonica. 133, 2, p. 63-68 6 p.

Research output: Contribution to journalArticle

Enzyme Activation
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Cyclic AMP
Signal Transduction
47 Citations (Scopus)

ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells

Obara, Y., Yamauchi, A., Takehara, S., Nemoto, W., Takahashi, M., Stork, P. & Nakahata, N., Aug 28 2009, In : Journal of Biological Chemistry. 284, 35, p. 23564-23573 10 p.

Research output: Contribution to journalArticle

PC12 Cells
Tyrosine 3-Monooxygenase
Nerve Growth Factor
Stabilization
Phosphorylation
2008
41 Citations (Scopus)

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

Liu, C., Takahashi, M., Li, Y., Song, S., Dillon, T. J., Shinde, U. & Stork, P., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7109-7125 17 p.

Research output: Contribution to journalArticle

Cyclic AMP
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
PC12 Cells
Exocytosis
2007
2 Citations (Scopus)

Putting on the RITz.

Kaech-Petrie, S., Banker, G. & Stork, P., Dec 11 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 416

Research output: Contribution to journalArticle

ras Proteins
Bone Morphogenetic Proteins
Dendrites
Drosophila melanogaster
Transforming Growth Factor beta

Rap1: Selective activator of β2 integrins?

Stork, P., Nov 15 2007, In : Blood. 110, 10, p. 3496-3497 2 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
T-cells
Chemokines
Integrins
Adhesion
45 Citations (Scopus)

The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells

Obara, Y., Horgan, A. & Stork, P., Apr 2007, In : Journal of Neurochemistry. 101, 2, p. 470-482 13 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Cyclic AMP
Chemical activation
Protein Kinases
Extracellular Signal-Regulated MAP Kinases
2006
121 Citations (Scopus)

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

Wang, Z., Dillon, T. J., Pokala, V., Mishra, S., Labudda, K., Hunter, B. & Stork, P., Mar 2006, In : Molecular and Cellular Biology. 26, 6, p. 2130-2145 16 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Guanine Nucleotide Exchange Factors
Adenylate Kinase
42 Citations (Scopus)
Proto-Oncogene Proteins c-fos
PC12 Cells
Extracellular Signal-Regulated MAP Kinases
Nerve Growth Factor
Transcriptional Activation
2005
19 Citations (Scopus)

Directing NGF's actions: It's a rap

Stork, P., Apr 2005, In : Nature Cell Biology. 7, 4, p. 338-339 2 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Extracellular Signal-Regulated MAP Kinases
Epidermal Growth Factor
73 Citations (Scopus)

Multiple roles of Rap1 in hematopoietic cells: Complementary versus antagonistic functions

Stork, P. & Dillon, T. J., Nov 2005, In : Blood. 106, 9, p. 2952-2961 10 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Extracellular Signal-Regulated MAP Kinases
Cell Proliferation
MAP Kinase Kinase Kinases
Adhesion
31 Citations (Scopus)

Ras-independent activation of ERK signaling via the Torso receptor tyrosine kinase is mediated by Rap1

Mishra, S., Smolik, S. M., Forte, M. & Stork, P., Feb 22 2005, In : Current Biology. 15, 4, p. 366-370 5 p.

Research output: Contribution to journalArticle

torso
Torso
Monomeric GTP-Binding Proteins
Receptor Protein-Tyrosine Kinases
mitogen-activated protein kinase
40 Citations (Scopus)

Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4

Dillon, T. J., Carey, K. D., Wetzel, S. A., Parker, D. & Stork, P., May 2005, In : Molecular and Cellular Biology. 25, 10, p. 4117-4128 12 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Extracellular Signal-Regulated MAP Kinases
T-Lymphocytes
Transgenic Mice
Interleukin-2

Unraveling the mysteries of B-Raf: The clot thickens!

Stork, P., Aug 1 2005, In : Blood. 106, 3, p. 775-776 2 p.

Research output: Contribution to journalArticle

Megakaryocytes
Hematopoiesis
2004
101 Citations (Scopus)

PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells

Obara, Y., Labudda, K., Dillon, T. J. & Stork, P., Dec 1 2004, In : Journal of Cell Science. 117, 25, p. 6085-6094 10 p.

Research output: Contribution to journalArticle

PC12 Cells
Nerve Growth Factor
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Phosphorylation
2003
74 Citations (Scopus)

Angiotensin II stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocytes

Sundgren, N. C., Giraud, G., Stork, P., Maylie, J. & Thornburg, K., May 1 2003, In : Journal of Physiology. 548, 3, p. 881-891 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Angiotensin II
Hypertrophy
Hyperplasia
Sheep
156 Citations (Scopus)

Does Rap1 deserve a bad Rap?

Stork, P., May 1 2003, In : Trends in Biochemical Sciences. 28, 5, p. 267-275 9 p.

Research output: Contribution to journalArticle

Cell Differentiation
Biological Phenomena
Neuronal Plasticity
Monomeric GTP-Binding Proteins
MAP Kinase Signaling System
24 Citations (Scopus)

Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy

Dillon, T. J., Karpitski, V., Wetzel, S. A., Parker, D., Shaw, A. S. & Stork, P., Sep 19 2003, In : Journal of Biological Chemistry. 278, 38, p. 35940-35949 10 p.

Research output: Contribution to journalArticle

T-cells
Extracellular Signal-Regulated MAP Kinases
Antigen-Presenting Cells
Chemical activation
T-Lymphocytes
50 Citations (Scopus)

Examining the mechanism of Erk nuclear translocation using green fluorescent protein

Horgan, A. & Stork, P., May 1 2003, In : Experimental Cell Research. 285, 2, p. 208-220 13 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
PC12 Cells
Nerve Growth Factor
Mitogen-Activated Protein Kinases
Cytoplasm
88 Citations (Scopus)
Mitogen-Activated Protein Kinase 6
Somatomedins
Cardiac Myocytes
Sheep
Phosphotransferases
40 Citations (Scopus)

The requirement of specific membrane domains for Raf-1 phosphorylation and activation

Carey, K. D., Watson, R. T., Pessin, J. E. & Stork, P., Jan 31 2003, In : Journal of Biological Chemistry. 278, 5, p. 3185-3196 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Tyrosine
Chemical activation
Membranes
Serine
2002
678 Citations (Scopus)

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

Stork, P. & Schmitt, J. M., Jun 1 2002, In : Trends in Cell Biology. 12, 6, p. 258-266 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Cyclic AMP
Cell Proliferation
Growth
GTP Phosphohydrolases
25 Citations (Scopus)

ERK signaling: duration, duration, duration.

Stork, P., Sep 2002, In : Cell cycle (Georgetown, Tex.). 1, 5, p. 315-317 3 p.

Research output: Contribution to journalArticle

Growth Substances
Proto-Oncogene Proteins c-fos
Mitogen-Activated Protein Kinases
Rats
Animals
54 Citations (Scopus)

Gα and Gβγ require distinct Src-dependent pathways to activate Rap1 and Ras

Schmitt, J. M. & Stork, P., Nov 8 2002, In : Journal of Biological Chemistry. 277, 45, p. 43024-43032 9 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Isoproterenol
Chemical activation
Phosphorylation
Adrenergic Agonists
192 Citations (Scopus)

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1

Schmitt, J. M. & Stork, P., 2002, In : Molecular Cell. 9, 1, p. 85-94 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Growth
Guanine Nucleotide-Releasing Factor 2
Monomeric GTP-Binding Proteins
src-Family Kinases
626 Citations (Scopus)

Signaling pathways for PC12 cell differentiation: Making the right connections

Vaudry, D., Stork, P., Lazarovici, P. & Eiden, L. E., May 31 2002, In : Science. 296, 5573, p. 1648-1649 2 p.

Research output: Contribution to journalArticle

PC12 Cells
Mitogen-Activated Protein Kinase Kinases
Nerve Growth Factor
Cell Differentiation
Signal Transduction
2001
110 Citations (Scopus)

Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1

Schmitt, J. M. & Stork, P., Jun 2001, In : Molecular and Cellular Biology. 21, 11, p. 3671-3683 13 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cyclic AMP
NIH 3T3 Cells
Mitogen-Activated Protein Kinases
Growth
31 Citations (Scopus)

Hormonal control of insulin-like growth factor I gene transcription in human osteoblasts: Dual actions of cAMP-dependent protein kinase on CCAAT/enhancer-binding protein δ

Billiard, J., Grewal, S. S., Lukaesko, L., Stork, P. & Rotwein, P., Aug 17 2001, In : Journal of Biological Chemistry. 276, 33, p. 31238-31246 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Osteoblasts
Transcription
Cyclic AMP-Dependent Protein Kinases
Insulin-Like Growth Factor I
4 Citations (Scopus)

Nonisotopic methods for detecting activation of small G proteins

Carey, K. D. & Stork, P., 2001, In : Methods. 345, p. 383-397 15 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
2000
112 Citations (Scopus)

Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap-1-extracellular signal-regulated kinase pathway

Grewal, S. S., Fass, D. M., Yao, H., Ellig, C. L., Goodman, R. & Stork, P., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34433-34441 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Carrier Proteins
Calcium
Extracellular Signal-Regulated MAP Kinases
Cyclic AMP-Dependent Protein Kinases
67 Citations (Scopus)

CD28 and the tyrosine kinase Lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1

Carey, K. D., Dillon, T. J., Schmitt, J. M., Baird, A. M., Holdorf, A. D., Straus, D. B., Shaw, A. S. & Stork, P., 2000, In : Molecular and Cellular Biology. 20, 22, p. 8409-8419 11 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Extracellular Signal-Regulated MAP Kinases
T-Cell Antigen Receptor
Mitogen-Activated Protein Kinases
Protein-Tyrosine Kinases
130 Citations (Scopus)

Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase

Grewal, S. S., Horgan, A., York, R. D., Withers, G. S., Banker, G. & Stork, P., Feb 4 2000, In : Journal of Biological Chemistry. 275, 5, p. 3722-3728 7 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Depolarization
Calcium
Extracellular Signal-Regulated MAP Kinases
PC12 Cells
194 Citations (Scopus)

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1

York, R. D., Molliver, D. C., Grewal, S. S., Stenberg, P. E., McCleskey, E. W. & Stork, P., 2000, In : Molecular and Cellular Biology. 20, 21, p. 8069-8083 15 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Extracellular Signal-Regulated MAP Kinases
Nerve Growth Factor
Endocytosis
PC12 Cells
61 Citations (Scopus)

Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: Role of the phosphotyrosine phosphatase SHP-2

Florio, T., Thellung, S., Arena, S., Corsaro, A., Bajetto, A., Schettini, G. & Stork, P., 2000, In : Journal of Physiology Paris. 94, 3-4, p. 239-250 12 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mitogen-Activated Protein Kinases
Somatostatin
Cell Proliferation
Non-Receptor Type 11 Protein Tyrosine Phosphatase
149 Citations (Scopus)
Monomeric GTP-Binding Proteins
Protein-Serine-Threonine Kinases
Extracellular Signal-Regulated MAP Kinases
Isoproterenol
Adrenergic Receptors