Peter Steyger

Professor

  • 2360 Citations
  • 27 h-Index
1989 …2021
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Research Output 1989 2019

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2019
5 Citations (Scopus)

Aminoglycoside- and cisplatin-induced ototoxicity: Mechanisms and otoprotective strategies

Kros, C. J. & Steyger, P. S., Nov 2019, In : Cold Spring Harbor Perspectives in Medicine. 9, 11, a033548.

Research output: Contribution to journalArticle

Audition
Aminoglycosides
Cisplatin
Cochlea
Environmental Exposure
8 Citations (Scopus)

Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier

Nyberg, S., Joan Abbott, N., Shi, X., Steyger, P. & Dabdoub, A., Jan 1 2019, In : Science Translational Medicine. 11, 482, eaao0935.

Research output: Contribution to journalArticle

Inner Ear
Therapeutics
Pharmaceutical Preparations
Cochlea
Blood-Brain Barrier
2 Citations (Scopus)

Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss

Jiang, M., Li, H., Johnson, A., Karasawa, T., Zhang, Y., Meier, W. B., Taghizadeh, F., Kachelmeier, A. & Steyger, P., Jul 17 2019, In : Science Advances. 5, 7, eaaw1836.

Research output: Contribution to journalArticle

Open Access
auditory defects
drugs
hair
infectious diseases
knockout mice
2018

Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells

Kachelmeier, A., Shola, T., Meier, W. B., Johnson, A., Jiang, M. & Steyger, P., Nov 1 2018, In : PLoS One. 13, 11, e0206628.

Research output: Contribution to journalArticle

Pixels
drugs
Algebra
Pharmaceutical Preparations
Image segmentation
2017
5 Citations (Scopus)

Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study

Garinis, A. C., Liao, S., Cross, C. P., Galati, J., Middaugh, J. L., Mace, J. C., Wood, A. M., McEvoy, L., Moneta, L., Lubianski, T., Coopersmith, N., Vigo, N., Hart, C., Riddle, A., Ettinger, O., Nold, C., Durham, H., Macarthur, C., McEvoy, C. C. & Steyger, P., Jun 1 2017, In : International Journal of Pediatric Otorhinolaryngology. 97, p. 42-50 9 p.

Research output: Contribution to journalArticle

Neonatal Intensive Care Units
Gentamicins
Hearing
Referral and Consultation
Brain Stem Auditory Evoked Potentials
8 Citations (Scopus)

Monitoring neonates for ototoxicity

Garinis, A. C., Kemph, A., Tharpe, A. M., Weitkamp, J. H., McEvoy, C. C. & Steyger, P., Jun 21 2017, (Accepted/In press) In : International Journal of Audiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Hearing Loss
Newborn Infant
monitoring
Neonatal Intensive Care Units
infant
2016
3 Citations (Scopus)

Rhodamine analogs for molecular ruler applications

Chu, Y. H., Escobedo, J. O., Jiang, M., Steyger, P. & Strongin, R. M., Mar 1 2016, In : Dyes and Pigments. 126, p. 46-53 8 p.

Research output: Contribution to journalArticle

Rhodamines
Fluorophores
Molecular mechanics
Biomolecules
Rigidity
4 Citations (Scopus)

Systemic Delivery and Biodistribution of Cisplatin in Vivo

Chu, Y. H., Sibrian-Vazquez, M., Escobedo, J. O., Phillips, A. R., Dickey, D. T., Wang, Q., Ralle, M., Steyger, P. & Strongin, R. M., Aug 1 2016, In : Molecular Pharmaceutics. 13, 8, p. 2677-2682 6 p.

Research output: Contribution to journalArticle

Cisplatin
Drug Therapy
Pharmaceutical Preparations
Neoplasms
19 Citations (Scopus)

The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis

Garinis, A. C., Cross, C. P., Srikanth, P., Carroll, K., Feeney, M. P., Keefe, D. H., Hunter, L. L., Putterman, D. B., Cohen, D., Gold, J. J. & Steyger, P., Jul 19 2016, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Cystic Fibrosis
Hearing
Anti-Bacterial Agents
Aminoglycosides
Hearing Loss
2015
5 Citations (Scopus)
Type 2 Diabetes Mellitus
Sodium-Glucose Transport Proteins
Pharmacology
Glucose
Expert Testimony
137 Citations (Scopus)

An integrated view of cisplatin-induced nephrotoxicity and ototoxicity

Karasawa, T. & Steyger, P., Sep 7 2015, In : Toxicology Letters. 237, 3, p. 219-227 9 p.

Research output: Contribution to journalArticle

Cisplatin
Poisons
Reactive Oxygen Species
Neoplasms
DNA
2 Citations (Scopus)

Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles

Yang, Y., Chen, F., Karasawa, T., Ma, K. T., Guan, B. C., Shi, X., Li, H., Steyger, P., Nuttall, A. & Jiang, Z-G., May 4 2015, In : PLoS One. 10, 5, e0125266.

Research output: Contribution to journalArticle

Arterioles
membrane potential
Membrane Potentials
Membranes
mesenteric arteries
16 Citations (Scopus)

Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure

Cross, C. P., Liao, S., Urdang, Z. D., Srikanth, P., Garinis, A. C. & Steyger, P., Aug 6 2015, (Accepted/In press) In : International Journal of Pediatric Otorhinolaryngology.

Research output: Contribution to journalArticle

Neonatal Screening
Systemic Inflammatory Response Syndrome
Gentamicins
Hearing
Neonatal Intensive Care Units
37 Citations (Scopus)

Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity

Koo, J. W., Quintanilla-Dieck, L., Jiang, M., Liu, J., Urdang, Z. D., Allensworth, J. J., Cross, C. P., Li, H. & Steyger, P., Jul 29 2015, In : Science Translational Medicine. 7, 298, 298ra118.

Research output: Contribution to journalArticle

Endotoxemia
Aminoglycosides
Inflammation
Cochlea
Lipopolysaccharides

Hearing Loss Risk Factors for Cystic Fibrosis Patients

Steyger, P. & Garinis, A. C., Jul 1 2015, In : Hearing Journal. 69, 4, p. 8-9 2 p.

Research output: Contribution to journalArticle

Hearing Loss
Cystic Fibrosis
13 Citations (Scopus)

Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells

Li, H., Kachelmeier, A., Furness, D. N. & Steyger, P., Apr 14 2015, In : Frontiers in Cellular Neuroscience. 9, APR, A130.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Aminoglycosides
Transducers
Cochlea
Gentamicins

Novel Aminoglycoside Antibiotics Show Reduced Ototoxicity Risk

Steyger, P., Jul 11 2015, In : Hearing Journal. 68, 4, p. 32-35 4 p.

Research output: Contribution to journalArticle

Aminoglycosides
Anti-Bacterial Agents
5 Citations (Scopus)

Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration

Liu, J., Kachelmeier, A., Dai, C., Li, H. & Steyger, P., Mar 20 2015, In : PLoS One. 10, 3, e0120612.

Research output: Contribution to journalArticle

gentamicin
Gentamicins
Fluorescence
fluorescence
cells
2014
33 Citations (Scopus)

Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides

Jiang, M., Wang, Q., Karasawa, T., Koo, J. W., Li, H. & Steyger, P., Sep 30 2014, In : PLoS One. 9, 9, e108941.

Research output: Contribution to journalArticle

Sodium-Glucose Transporter 2
sodium glucose transporter
aminoglycosides
Aminoglycosides
gentamicin
2013
16 Citations (Scopus)

Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)

Uribe, P. M., Sun, H., Wang, K., Asuncion, J. D., Wang, Q., Chen, C. W., Steyger, P., Smith, M. E. & Matsui, J. I., Mar 22 2013, In : PLoS One. 8, 3, e58755.

Research output: Contribution to journalArticle

aminoglycosides
Aminoglycosides
Zebrafish
Inner Ear
Cell death
8 Citations (Scopus)

Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels

Wang, T., Yang, Y. Q., Karasawa, T., Wang, Q., Phillips, A., Guan, B. C., Ma, K. T., Jiang, M., Xie, D. H., Steyger, P. & Jiang, Z-G., 2013, In : Cell Biochemistry and Biophysics. 65, 3, p. 381-398 18 p.

Research output: Contribution to journalArticle

Bumetanide
Madin Darby Canine Kidney Cells
Potassium Channels
Gentamicins
Furosemide
18 Citations (Scopus)

Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio)

Uribe, P. M., Mueller, M. A., Gleichman, J. S., Kramer, M. D., Wang, Q., Sibrian-Vazquez, M., Strongin, R. M., Steyger, P., Cotanche, D. A. & Matsui, J. I., Feb 1 2013, In : PLoS One. 8, 2, e55359.

Research output: Contribution to journalArticle

cisplatin
Zebrafish
Cell death
dimethyl sulfoxide
Dimethyl Sulfoxide
9 Citations (Scopus)

Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea: A pilot study

Quintanilla-Dieck, L., Larrain, B., Trune, D. & Steyger, P., Aug 2013, In : Otolaryngology - Head and Neck Surgery (United States). 149, 2, p. 301-303 3 p.

Research output: Contribution to journalArticle

Cochlea
Lipopolysaccharides
Cytokines
Inflammation
Gentamicins
25 Citations (Scopus)

Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds

Karasawa, T., Sibrian-Vazquez, M., Strongin, R. M. & Steyger, P., Jun 3 2013, In : PLoS One. 8, 6, e66220.

Research output: Contribution to journalArticle

Platinum Compounds
platinum
cisplatin
Sepharose
agarose

Ototoxic antibiotics: Research unlocks key mechanism for cochlear hair cell entry

Steyger, P., Apr 2013, In : Hearing Journal. 66, 4, p. 24-26 3 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Anti-Bacterial Agents
Research
1 Citation (Scopus)

Preclinical and clinical studies of unrelieved aural fullness following intratympanic gentamicin injection in patients with intractable Ménière's disease

Zhai, F., Zhang, R., Zhang, T., Steyger, P. & Dai, C. F., 2013, In : Audiology and Neurotology. 18, 5, p. 297-306 10 p.

Research output: Contribution to journalArticle

Gentamicins
Ear
Vertigo
Guinea Pigs
Intratympanic Injection
7 Citations (Scopus)

Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs

Zhang, R., Zhang, Y. B., Dai, C. F. & Steyger, P., Apr 2013, In : Hearing Research. 298, p. 49-59 11 p.

Research output: Contribution to journalArticle

Gentamicins
Guinea Pigs
Fluorescence
Semicircular Canals
Intratympanic Injection
2012

Journal club: New evidence reveals how ototoxic antibiotics cause hair cell death

Steyger, P., Apr 2012, In : Hearing Journal. 65, 4, p. 18-20 3 p.

Research output: Contribution to journalArticle

Cell Death
Anti-Bacterial Agents
5 Citations (Scopus)

Live cell imaging of a fluorescent gentamicin conjugate

Escobedo, J. O., Chu, Y. H., Wang, Q., Steyger, P. & Strongin, R. M., 2012, In : Natural Product Communications. 7, 3, p. 317-320 4 p.

Research output: Contribution to journalArticle

gentamicin
Gentamicins
image analysis
aminoglycoside antibiotics
uptake mechanisms
167 Citations (Scopus)

Platinum-induced ototoxicity in children: A consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale

Brock, P. R., Knight, K., Freyer, D. R., Campbell, K. C. M., Steyger, P., Blakley, B. W., Rassekh, S. R., Chang, K. W., Fligor, B. J., Rajput, K., Sullivan, M. & Neuwelt, E., Jul 1 2012, In : Journal of Clinical Oncology. 30, 19, p. 2408-2417 10 p.

Research output: Contribution to journalArticle

Platinum
Consensus
Pediatrics
Hearing Loss
Cisplatin
10 Citations (Scopus)

Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs

Zhang, Y. B., Zhang, R., Zhang, W. F., Steyger, P. & Dai, C. F., Jan 2012, In : Hearing Research. 283, 1-2, p. 169-179 11 p.

Research output: Contribution to journalArticle

Efferent Neurons
Gentamicins
Guinea Pigs
Cochlear Nucleus
Axonal Transport
2011
27 Citations (Scopus)

Acoustic trauma increases cochlear and hair cell uptake of gentamicin

Li, H., Wang, Q. & Steyger, P., 2011, In : PLoS One. 6, 4, e19130.

Research output: Contribution to journalArticle

Auditory Hair Cells
Noise-Induced Hearing Loss
gentamicin
Gentamicins
hairs
15 Citations (Scopus)

Calreticulin binds to gentamicin and reduces drug-induced ototoxicity

Karasawa, T., Wang, Q., David, L. & Steyger, P., Dec 2011, In : Toxicological Sciences. 124, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

Calreticulin
Gentamicins
Aminoglycosides
Pharmaceutical Preparations
Cytotoxicity
124 Citations (Scopus)

Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity

Alharazneh, A., Luk, L., Huth, M., Monfared, A., Steyger, P., Cheng, A. G. & Ricci, A. J., 2011, In : PLoS One. 6, 7, e22347.

Research output: Contribution to journalArticle

aminoglycosides
Aminoglycosides
hairs
Cells
Cell death
14 Citations (Scopus)

Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin

Koo, J. W., Wang, Q. & Steyger, P., Sep 2011, In : Audiology and Neurotology. 16, 6, p. 347-358 12 p.

Research output: Contribution to journalArticle

Cochlea
Gentamicins
Inner Ear
Peptides
Histamine
32 Citations (Scopus)

Intracellular mechanisms of aminoglycoside-induced cytotoxicity

Karasawa, T. & Steyger, P., Sep 2011, In : Integrative Biology. 3, 9, p. 879-886 8 p.

Research output: Contribution to journalArticle

Aminoglycosides
Cytotoxicity
Caspase 2
Calreticulin
Drug therapy
44 Citations (Scopus)

Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells

Li, H. & Steyger, P., 2011, In : Scientific Reports. 1, 159.

Research output: Contribution to journalArticle

Auditory Hair Cells
Endolymph
Aminoglycosides
Perilymph
Inner Ear
42 Citations (Scopus)

TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells

Stepanyan, R. S., Indzhykulian, A. A., Catalinavélez-Ortega, A., Boger, E. T., Steyger, P., Friedman, T. B. & Frolenkov, G. I., Dec 2011, In : JARO - Journal of the Association for Research in Otolaryngology. 12, 6, p. 729-740 12 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Aminoglycosides
Gentamicins
Cations
Inner Auditory Hair Cells
2010
22 Citations (Scopus)

CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity

Karasawa, T., Wang, Q., David, L. & Steyger, P., Nov 2010, In : Cell Death and Disease. 1, 11, e102.

Research output: Contribution to journalArticle

Gentamicins
Cytoskeleton
Carrier Proteins
Membrane Proteins
Pharmaceutical Preparations
5 Citations (Scopus)

Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window

Zhang, Y., Zhang, R., Dai, C., Steyger, P. & Yongfu, Y. Y., Oct 2010, In : Laryngoscope. 120, 10, p. 2054-2060 7 p.

Research output: Contribution to journalArticle

Endolymphatic Sac
Inner Ear
Gentamicins
Cochlea
Meniere Disease
19 Citations (Scopus)

Competitive antagonism of fluorescent gentamicin uptake in the cochlea

Wang, Q., Kachelmeier, A. & Steyger, P., Sep 2010, In : Hearing Research. 268, 1-2, p. 250-259 10 p.

Research output: Contribution to journalArticle

Cochlea
Gentamicins
Aminoglycosides
Stria Vascularis
Inner Ear
15 Citations (Scopus)

Evidence-Based modification of intratympanic gentamicin injections in patients with intractable vertigo

Zhai, F., Liu, J. P., Dai, C. F., Wang, Q. & Steyger, P., Jun 2010, In : Otology and Neurotology. 31, 4, p. 642-648 7 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Vertigo
Gentamicins
Cochlea
Guinea Pigs
2009
20 Citations (Scopus)

Metabolic imaging of the organ of corti - A window on cochlea bioenergetics

Tiede, L., Steyger, P., Nichols, M. G. & Hallworth, R., Jun 24 2009, In : Brain Research. 1277, p. 37-41 5 p.

Research output: Contribution to journalArticle

Organ of Corti
Cochlea
Energy Metabolism
NAD
Alopecia
13 Citations (Scopus)

Potentiation of chemical ototoxicity by noise

Steyger, P., Feb 2009, In : Seminars in Hearing. 30, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

Noise
Aminoglycosides
Hearing Loss
Cisplatin
Auditory Perception
42 Citations (Scopus)

Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics

Li, H. & Steyger, P., Jan 1 2009, In : Noise and Health. 11, 42, p. 26-32 7 p.

Research output: Contribution to journalArticle

Aminoglycosides
Noise
Anti-Bacterial Agents
Cochlea
Acoustics
89 Citations (Scopus)

Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells

Wang, Q. & Steyger, P., Jun 2009, In : JARO - Journal of the Association for Research in Otolaryngology. 10, 2, p. 205-219 15 p.

Research output: Contribution to journalArticle

Cochlea
Gentamicins
Aminoglycosides
Endolymph
Zebrafish
2008
45 Citations (Scopus)

A systemic gentamicin pathway across the stria vascularis

Dai, C. F. & Steyger, P., Jan 2008, In : Hearing Research. 235, 1-2, p. 114-124 11 p.

Research output: Contribution to journalArticle

Stria Vascularis
Gentamicins
Cochlea
Fluorescence
Endolymph
51 Citations (Scopus)

TRPV4 enhances the cellular uptake of aminoglycoside antibiotics

Karasawa, T., Wang, Q., Fu, Y., Cohen, D. & Steyger, P., Sep 1 2008, In : Journal of Cell Science. 121, 17, p. 2871-2879 9 p.

Research output: Contribution to journalArticle

Aminoglycosides
Gentamicins
Anti-Bacterial Agents
Cell Line
Cochlea
2007
23 Citations (Scopus)

Closure of supporting cell scar formations requires dynamic actin mechanisms

Hordichok, A. J. & Steyger, P., Oct 2007, In : Hearing Research. 232, 1-2, p. 1-19 19 p.

Research output: Contribution to journalArticle

Cicatrix
Actins
Saccule and Utricle
Rana catesbeiana
Myosins
2006
63 Citations (Scopus)

Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo

Dai, C. F., Mangiardi, D., Cotanche, D. A. & Steyger, P., Mar 2006, In : Hearing Research. 213, 1-2, p. 64-78 15 p.

Research output: Contribution to journalArticle

Gentamicins
Vertebrates
Aminoglycosides
Inner Ear
Guinea Pigs