Peter Steyger

Professor

  • 2494 Citations
  • 27 h-Index
1989 …2019

Research output per year

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Research Output

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Article
2019

Aminoglycoside- and cisplatin-induced ototoxicity: Mechanisms and otoprotective strategies

Kros, C. J. & Steyger, P. S., Nov 2019, In : Cold Spring Harbor Perspectives in Medicine. 9, 11, a033548.

Research output: Contribution to journalArticle

8 Scopus citations

Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier

Nyberg, S., Joan Abbott, N., Shi, X., Steyger, P. S. & Dabdoub, A., Jan 1 2019, In : Science translational medicine. 11, 482, eaao0935.

Research output: Contribution to journalArticle

14 Scopus citations

Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss

Jiang, M., Li, H., Johnson, A., Karasawa, T., Zhang, Y., Meier, W. B., Taghizadeh, F., Kachelmeier, A. & Steyger, P. S., Jul 17 2019, In : Science Advances. 5, 7, eaaw1836.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells

Kachelmeier, A., Shola, T., Meier, W. B., Johnson, A., Jiang, M. & Steyger, P. S., Nov 2018, In : PloS one. 13, 11, e0206628.

Research output: Contribution to journalArticle

2017

Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study

Garinis, A. C., Liao, S., Cross, C. P., Galati, J., Middaugh, J. L., Mace, J. C., Wood, A. M., McEvoy, L., Moneta, L., Lubianski, T., Coopersmith, N., Vigo, N., Hart, C., Riddle, A., Ettinger, O., Nold, C., Durham, H., MacArthur, C., McEvoy, C. & Steyger, P. S., Jun 1 2017, In : International Journal of Pediatric Otorhinolaryngology. 97, p. 42-50 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Monitoring neonates for ototoxicity

Garinis, A. C., Kemph, A., Tharpe, A. M., Weitkamp, J. H., McEvoy, C. C. & Steyger, P., Jun 21 2017, (Accepted/In press) In : International Journal of Audiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis

Garinis, A. C., Cross, C. P., Srikanth, P., Carroll, K., Feeney, M. P., Keefe, D. H., Hunter, L. L., Putterman, D. B., Cohen, D. M., Gold, J. A. & Steyger, P. S., May 2017, In : Journal of Cystic Fibrosis. 16, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

Rhodamine analogs for molecular ruler applications

Chu, Y. H., Escobedo, J. O., Jiang, M., Steyger, P. & Strongin, R. M., Mar 1 2016, In : Dyes and Pigments. 126, p. 46-53 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Systemic Delivery and Biodistribution of Cisplatin in Vivo

Chu, Y. H., Sibrian-Vazquez, M., Escobedo, J. O., Phillips, A. R., Dickey, D. T., Wang, Q., Ralle, M., Steyger, P. & Strongin, R. M., Aug 1 2016, In : Molecular Pharmaceutics. 13, 8, p. 2677-2682 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles

Yang, Y., Chen, F., Karasawa, T., Ma, K. T., Guan, B. C., Shi, X. R., Li, H., Steyger, P. S., Nuttall, A. L. & Jiang, Z. G., May 4 2015, In : PloS one. 10, 5, e0125266.

Research output: Contribution to journalArticle

2 Scopus citations

Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure

Cross, C. P., Liao, S., Urdang, Z. D., Srikanth, P., Garinis, A. C. & Steyger, P., Aug 6 2015, (Accepted/In press) In : International Journal of Pediatric Otorhinolaryngology.

Research output: Contribution to journalArticle

17 Scopus citations

Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity

Koo, J. W., Quintanilla-Dieck, L., Jiang, M., Liu, J., Urdang, Z. D., Allensworth, J. J., Cross, C. P., Li, H. & Steyger, P. S., Jul 29 2015, In : Science translational medicine. 7, 298, 298ra118.

Research output: Contribution to journalArticle

40 Scopus citations

Hearing Loss Risk Factors for Cystic Fibrosis Patients

Steyger, P. & Garinis, A. C., Jul 1 2015, In : Hearing Journal. 69, 4, p. 8-9 2 p.

Research output: Contribution to journalArticle

Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells

Li, H., Kachelmeier, A., Furness, D. N. & Steyger, P. S., Apr 14 2015, In : Frontiers in Cellular Neuroscience. 9, APR, A130.

Research output: Contribution to journalArticle

13 Scopus citations

Novel Aminoglycoside Antibiotics Show Reduced Ototoxicity Risk

Steyger, P. S., Jul 11 2015, In : Hearing Journal. 68, 4, p. 32-35 4 p.

Research output: Contribution to journalArticle

Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration

Liu, J., Kachelmeier, A., Dai, C., Li, H. & Steyger, P. S., Mar 20 2015, In : PloS one. 10, 3, e0120612.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides

Jiang, M., Wang, Q., Karasawa, T., Koo, J. W., Li, H. & Steyger, P. S., Sep 30 2014, In : PloS one. 9, 9, e108941.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)

Uribe, P. M., Sun, H., Wang, K., Asuncion, J. D., Wang, Q., Chen, C. W., Steyger, P. S., Smith, M. E. & Matsui, J. I., Mar 22 2013, In : PloS one. 8, 3, e58755.

Research output: Contribution to journalArticle

17 Scopus citations

Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels

Wang, T., Yang, Y. Q., Karasawa, T., Wang, Q., Phillips, A., Guan, B. C., Ma, K. T., Jiang, M., Xie, D. H., Steyger, P. S. & Jiang, Z. G., Jan 1 2013, In : Cell Biochemistry and Biophysics. 65, 3, p. 381-398 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio)

Uribe, P. M., Mueller, M. A., Gleichman, J. S., Kramer, M. D., Wang, Q., Sibrian-Vazquez, M., Strongin, R. M., Steyger, P. S., Cotanche, D. A. & Matsui, J. I., Feb 1 2013, In : PloS one. 8, 2, e55359.

Research output: Contribution to journalArticle

19 Scopus citations

Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea: A pilot study

Quintanilla-Dieck, L., Larrain, B., Trune, D. & Steyger, P. S., Aug 1 2013, In : Otolaryngology - Head and Neck Surgery (United States). 149, 2, p. 301-303 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds

Karasawa, T., Sibrian-Vazquez, M., Strongin, R. M. & Steyger, P. S., Jun 3 2013, In : PloS one. 8, 6, e66220.

Research output: Contribution to journalArticle

27 Scopus citations

Ototoxic antibiotics: Research unlocks key mechanism for cochlear hair cell entry

Steyger, P. S., Apr 1 2013, In : Hearing Journal. 66, 4, p. 24-26 3 p.

Research output: Contribution to journalArticle

Preclinical and clinical studies of unrelieved aural fullness following intratympanic gentamicin injection in patients with intractable Ménière's disease

Zhai, F., Zhang, R., Zhang, T., Steyger, P. S. & Dai, C. F., Jan 1 2013, In : Audiology and Neurotology. 18, 5, p. 297-306 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs

Zhang, R., Zhang, Y. B., Dai, C. F. & Steyger, P. S., Apr 1 2013, In : Hearing Research. 298, p. 49-59 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Journal club: New evidence reveals how ototoxic antibiotics cause hair cell death

Steyger, P. S., Apr 1 2012, In : Hearing Journal. 65, 4, p. 18-20 3 p.

Research output: Contribution to journalArticle

Live cell imaging of a fluorescent gentamicin conjugate

Escobedo, J. O., Chu, Y. H., Wang, Q., Steyger, P. S. & Strongin, R. M., May 14 2012, In : Natural Product Communications. 7, 3, p. 317-320 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs

Zhang, Y. B., Zhang, R., Zhang, W. F., Steyger, P. S. & Dai, C. F., Jan 1 2012, In : Hearing Research. 283, 1-2, p. 169-179 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Acoustic trauma increases cochlear and hair cell uptake of gentamicin

Li, H., Wang, Q. & Steyger, P. S., 2011, In : PloS one. 6, 4, e19130.

Research output: Contribution to journalArticle

27 Scopus citations

Calreticulin binds to gentamicin and reduces drug-induced ototoxicity

Karasawa, T., Wang, Q., David, L. L. & Steyger, P. S., Dec 2011, In : Toxicological Sciences. 124, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity

Alharazneh, A., Luk, L., Huth, M., Monfared, A., Steyger, P. S., Cheng, A. G. & Ricci, A. J., 2011, In : PloS one. 6, 7, e22347.

Research output: Contribution to journalArticle

127 Scopus citations

Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin

Koo, J. W., Wang, Q. & Steyger, P. S., Sep 1 2011, In : Audiology and Neurotology. 16, 6, p. 347-358 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells

Li, H. & Steyger, P. S., Dec 1 2011, In : Scientific Reports. 1, 159.

Research output: Contribution to journalArticle

45 Scopus citations

TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells

Stepanyan, R. S., Indzhykulian, A. A., Catalinavélez-Ortega, A., Boger, E. T., Steyger, P. S., Friedman, T. B. & Frolenkov, G. I., Dec 1 2011, In : JARO - Journal of the Association for Research in Otolaryngology. 12, 6, p. 729-740 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity

Karasawa, T., Wang, Q., David, L. L. & Steyger, P. S., Nov 1 2010, In : Cell Death and Disease. 1, 11, e102.

Research output: Contribution to journalArticle

22 Scopus citations

Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window

Zhang, Y., Zhang, R., Dai, C., Steyger, P. S. & Yongfu, Y. Y., Oct 1 2010, In : Laryngoscope. 120, 10, p. 2054-2060 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Competitive antagonism of fluorescent gentamicin uptake in the cochlea

Wang, Q., Kachelmeier, A. & Steyger, P. S., Sep 1 2010, In : Hearing Research. 268, 1-2, p. 250-259 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Evidence-Based modification of intratympanic gentamicin injections in patients with intractable vertigo

Zhai, F., Liu, J. P., Dai, C. F., Wang, Q. & Steyger, P. S., Jun 1 2010, In : Otology and Neurotology. 31, 4, p. 642-648 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

Metabolic imaging of the organ of corti - A window on cochlea bioenergetics

Tiede, L. A., Steyger, P. S., Nichols, M. G. & Hallworth, R., Jun 24 2009, In : Brain research. 1277, p. 37-41 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Potentiation of chemical ototoxicity by noise

Steyger, P. S., Feb 1 2009, In : Seminars in Hearing. 30, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells

Wang, Q. & Steyger, P. S., Jun 1 2009, In : JARO - Journal of the Association for Research in Otolaryngology. 10, 2, p. 205-219 15 p.

Research output: Contribution to journalArticle

91 Scopus citations
2008

A systemic gentamicin pathway across the stria vascularis

Dai, C. F. & Steyger, P. S., Jan 1 2008, In : Hearing Research. 235, 1-2, p. 114-124 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

TRPV4 enhances the cellular uptake of aminoglycoside antibiotics

Karasawa, T., Wang, Q., Fu, Y., Cohen, D. M. & Steyger, P. S., Sep 1 2008, In : Journal of Cell Science. 121, 17, p. 2871-2879 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
2007

Closure of supporting cell scar formations requires dynamic actin mechanisms

Hordichok, A. J. & Steyger, P. S., Oct 1 2007, In : Hearing Research. 232, 1-2, p. 1-19 19 p.

Research output: Contribution to journalArticle

24 Scopus citations
2006

Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo

Dai, C. F., Mangiardi, D., Cotanche, D. A. & Steyger, P. S., Mar 1 2006, In : Hearing Research. 213, 1-2, p. 64-78 15 p.

Research output: Contribution to journalArticle

64 Scopus citations
2005

Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis

Myrdal, S. E., Johnson, K. C. & Steyger, P. S., Jun 1 2005, In : Hearing Research. 204, 1-2, p. 156-169 14 p.

Research output: Contribution to journalArticle

65 Scopus citations

TRPV1 regulators mediate gentamicin penetration of cultured kidney cells

Myrdal, S. E. & Steyger, P. S., Jun 1 2005, In : Hearing Research. 204, 1-2, p. 170-182 13 p.

Research output: Contribution to journalArticle

74 Scopus citations
2004

Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries

Vass, Z., Dai, C. F., Steyger, P. S., Jancsó, G., Trune, D. R. & Nuttall, A. L., Mar 22 2004, In : Neuroscience. 124, 4, p. 919-927 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Expression of Trk A receptors in the mammalian inner ear

Dai, C. F., Steyger, P. S., Wang, Z. M., Vass, Z. & Nuttall, A. L., Jan 2004, In : Hearing Research. 187, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2003

Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti

Jensen-Smith, H. C., Eley, J., Steyger, P. S., Ludueña, R. F. & Hallworth, R., Feb 1 2003, In : Journal of Neurocytology. 32, 2, p. 185-197 13 p.

Research output: Contribution to journalArticle

23 Scopus citations