Peter Spencer

Professor

  • 12793 Citations
  • 61 h-Index
1970 …2020

Research output per year

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Research Output

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Article
2019

Carcinogenic risk of N-Nitrosamines in Shanghai Drinking Water: Indications for the Use of Ozone Pretreatment

Chen, Z., Yang, L., Huang, Y., Spencer, P., Zheng, W., Zhou, Y., Jiang, S., Ye, W., Zheng, Y. & Qu, W., Jun 18 2019, In : Environmental Science and Technology. 53, 12, p. 7007-7018 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dysregulation of Myosin Complex and Striated Muscle Contraction Pathway in the Brains of ALS-SOD1 Model Mice

Xu, B., Zheng, C., Chen, X., Zhang, Z., Liu, J., Spencer, P. & Yang, X., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, p. 2408-2417 10 p.

Research output: Contribution to journalArticle

Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease

Chen, C., Jiang, X., Li, Y., Yu, H., Li, S., Zhang, Z., Xu, H., Yang, Y., Liu, G., Zhu, F., Ren, X., Zou, L., Xu, B., Liu, J., Spencer, P. S. & Yang, X., May 1 2019, In : Free Radical Biology and Medicine. 135, p. 144-156 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

A real-time medical cartography of epidemic disease (Nodding syndrome) using village-based lay mHealth reporters

Valdes Angues, R., Suits, A., Palmer, V. S., Okot, C., Okot, R. A., Atonywalo, C., Gazda, S. K., Kitara, D. L., Lantum, M. & Spencer, P. S., Jun 2018, In : PLoS neglected tropical diseases. 12, 6, e0006588.

Research output: Contribution to journalArticle

2 Scopus citations

Heavy Exposure of Waste Collectors to Polycyclic Aromatic Hydrocarbons in a Poor Rural Area of Middle China

Zheng, J., Zheng, W., Zhou, Y., Jiang, S., Spencer, P., Ye, W., Zheng, Y., He, G. & Qu, W., Aug 7 2018, In : Environmental Science and Technology. 52, 15, p. 8866-8875 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mitochondrial molecular abnormalities revealed by proteomic analysis of hippocampal organelles of mice triple transgenic for alzheimer disease

Yu, H., Lin, X., Wang, D., Zhang, Z., Guo, Y., Ren, X., Xu, B., Yuan, J., Liu, J., Spencer, P. S., Wang, J. Z. & Yang, X., Mar 9 2018, In : Frontiers in Molecular Neuroscience. 11, 74.

Research output: Contribution to journalArticle

8 Scopus citations

Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer’s disease

Yu, H., Wang, D., Zou, L., Zhang, Z., Xu, H., Zhu, F., Ren, X., Xu, B., Yuan, J., Liu, J., Spencer, P. & Yang, X., Jan 30 2018, (Accepted/In press) In : Archives of Toxicology. p. 1-20 20 p.

Research output: Contribution to journalArticle

4 Scopus citations

The isoquinoline alkaloid dauricine targets multiple molecular pathways to ameliorate Alzheimer-like pathological changes in vitro

Liu, P., Chen, X., Zhou, H., Wang, L., Zhang, Z., Ren, X., Zhu, F., Guo, Y., Huang, X., Liu, J., Spencer, P. S. & Yang, X., 2018, In : Oxidative medicine and cellular longevity. 2018, 2025914.

Research output: Contribution to journalArticle

2 Scopus citations

The Prenylflavonoid xanthohumol reduces Alzheimer-Like changes and modulates multiple pathogenic molecular pathways in the Neuro2a/APPswe cell model of AD

Huang, X., Wang, J., Chen, X., Liu, P., Wang, S., Song, F., Zhang, Z., Zhu, F., Huang, X., Liu, J., Song, G., Spencer, P. S. & Yang, X., Apr 4 2018, In : Frontiers in Pharmacology. 9, APR, 199.

Research output: Contribution to journalArticle

5 Scopus citations

TRPC1 deletion causes striatal neuronal cell apoptosis and proteomic alterations in mice

Wang, D., Yu, H., Xu, B., Xu, H., Zhang, Z., Ren, X., Yuan, J., Liu, J., Guo, Y., Spencer, P. S. & Yang, X., Mar 20 2018, In : Frontiers in Aging Neuroscience. 10, MAR, 72.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Environmental, dietary and case-control study of Nodding Syndrome in Uganda: A post-measles brain disorder triggered by malnutrition?

other Members of the Oregon-Uganda Nodding Syndrome Research Team, Oct 15 2016, In : Journal of the Neurological Sciences. 369, p. 191-203 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Global environmental contamination: Challenge for the human brain

Soulimani, R. & Spencer, P., Mar 1 2016, In : NeuroToxicology. 53, p. 301 1 p.

Research output: Contribution to journalArticle

Nodding syndrome: 2015 International Conference Report and Gulu Accord

Spencer, P., Kitara, D. L., Gazda, S. K. & Winkler, A. S., Jun 1 2016, In : eNeurologicalSci. 3, p. 80-83 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Parkinson's disease and solvents: Is there a causal link?

Reis, J., Benbrick, E., Bonneterre, V. & Spencer, P., Dec 1 2016, In : Revue Neurologique. 172, 12, p. 761-765 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Seeking environmental causes of neurodegenerative disease and envisioning primary prevention

Spencer, P. S., Palmer, V. S. & Kisby, G. E., Sep 1 2016, In : NeuroToxicology. 56, p. 269-283 15 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Interprofessional global health education in a cosmopolitan community of North America: The iCHEE experience

Palmer, V. S., Mazumder, R. & Spencer, P. S., Aug 2014, In : Academic Medicine. 89, 8, p. 1149-1152 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Nodding syndrome in Kitgum District, Uganda: Association with conflict and internal displacement

Landis, J. L., Palmer, V. S. & Spencer, P. S., 2014, In : BMJ open. 4, 11, 006195.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Animal models of brain maldevelopment induced by cycad plant genotoxins

Kisby, G. E., Moore, H. & Spencer, P. S., Dec 2013, In : Birth Defects Research Part C - Embryo Today: Reviews. 99, 4, p. 247-255 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Nodding syndrome: Origins and natural history of a longstanding epileptic disorder in sub-Saharan Africa

Spencer, P. S., Palmer, V. S. & Jilek-Aall, L., 2013, In : African Health Sciences. 13, 2, p. 176-182 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors

Spencer, P. S., Vandemaele, K., Richer, M., Palmer, V. S., Chungong, S., Anker, M., Ayana, Y., Opoka, M. L., Klaucke, B. N., Quarello, A. & Tumwine, J. K., 2013, In : African Health Sciences. 13, 2, p. 183-204 22 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

Clinical and epidemiologic characteristics of nodding syndrome in mundri county, southern Sudan

Tumwine, J. K., Vandemaele, K., Chungong, S., Richer, M., Anker, M., Ayana, Y., Opoka, M. L., Klaucke, D. N., Quarello, A. & Spencer, P. S., 2012, In : African Health Sciences. 12, 3, p. 242-248 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Unraveling 50-yearold clues linking neurodegeneration and cancer to cycad toxins: Are microRNAs common mediators?

Spencer, P., Fry, R. C. & Kisby, G. E., Dec 1 2012, In : Frontiers in Genetics. 3, SEP, Article 192.

Research output: Contribution to journalArticle

20 Scopus citations
2011
46 Scopus citations

The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner

Kisby, G. E., Fry, R. C., Lasarev, M. R., Bammler, T. K., Beyer, R. P., Churchwell, M., Doerge, D. R., Meira, L. B., Palmer, V. S., Ramos-Crawford, A. L., Ren, X., Sullivan, R. C., Kavanagh, T. J., Samson, L. D., Zarbl, H. & Spencer, P. S., 2011, In : PloS one. 6, 6, e20911.

Research output: Contribution to journalArticle

27 Scopus citations
2009

New insights into mechanisms of γ-Diketone-induced axonopathy

Tshala-Katumbay, D., Desjardins, P., Sabri, M., Butterworth, R. & Spencer, P., Apr 30 2009, In : Neurochemical Research. 34, 11, p. 1919-1923 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-Hexanedione, the neurotoxic metabolite of the aliphatic solvent n-Hexane

Tshala-Katumbay, D., Monterroso, V., Kayton, R., Lasarev, M., Sabri, M. & Spencer, P., 2009, In : Toxicological Sciences. 107, 2, p. 482-489 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2008

Probing mechanisms of axonopathy. Part I: Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene

Tshala-Katumbay, D., Monterroso, V., Kayton, R., Lasarev, M., Sabri, M. & Spencer, P., 2008, In : Toxicological Sciences. 105, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2007

Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport

Sabri, M. I., Hashemi, S. B., Lasarev, M. R. & Spencer, P. S., Dec 1 2007, In : Neurochemical Research. 32, 12, p. 2152-2159 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses

Beyer, R. P., Fry, R. C., Lasarev, M. R., McConnachie, L. A., Meira, L. B., Palmer, V. S., Powell, C. L., Ross, P. K., Bammler, T. K., Bradford, B. U., Cranson, A. B., Cunningham, M. L., Fannin, R. D., Higgins, G. M., Hurban, P., Kayton, R. J., Kerr, K. F., Kosyk, O., Lobenhofer, E. K., Sieber, S. O. & 15 others, Vliet, P. A., Weis, B. K., Wolfinger, R., Woods, C. G., Freedman, J. H., Linney, E., Kaufmann, W. K., Kavanagh, T. J., Paules, R. S., Rusyn, I., Samson, L. D., Spencer, P. S., Suk, W., Tennant, R. J. & Zarbl, H., Sep 2007, In : Toxicological Sciences. 99, 1, p. 326-337 12 p.

Research output: Contribution to journalArticle

64 Scopus citations
2006

Monocyclic and dicyclic hydrocarbons: Structural requirements for proximal giant axonopathy

Tshala-Katumbay, D. D., Palmer, V. S., Lasarev, M. R., Kayton, R. J., Sabri, M. I. & Spencer, P. S., Sep 1 2006, In : Acta Neuropathologica. 112, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2005

A new murine model of giant proximal axonopathy

Tshala-Katumbay, D. D., Palmer, V. S., Kayton, R. J., Sabri, M. I. & Spencer, P. S., Apr 1 2005, In : Acta Neuropathologica. 109, 4, p. 405-410 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

On the decline and etiology of high-incidence motor system disease in West Papua (Southwest New Guinea)

Spencer, P. S., Palmer, V. S. & Ludolph, A. C., Oct 17 2005, In : Movement Disorders. 20, SUPPL. 12, p. S119-S126

Research output: Contribution to journalArticle

30 Scopus citations

Standardizing global gene expression analysis between laboratories and across platforms

Bammler, T., Beyer, R. P., Bhattacharya, S., Boorman, G. A., Boyles, A., Bradford, B. U., Bumgarner, R. E., Bushel, P. R., Chaturvedi, K., Choi, D., Cunningham, M. L., Deng, S., Dressman, H. K., Fannin, R. D., Farin, F. M., Freedman, J. H., Fry, R. C., Harper, A., Humble, M. C., Hurban, P. & 44 others, Kavanagh, T. J., Kaufmann, W. K., Kerr, K. F., Jing, L., Lapidus, J. A., Lasarev, M. R., Li, J., Li, Y. J., Lobenhofer, E. K., Lu, X., Malek, R. L., Milton, S., Nagalla, S. R., O'Malley, J. P., Palmer, V. S., Pattee, P., Paules, R. S., Perou, C. M., Phillips, K., Qin, L. X., Qiu, Y., Quigley, S. D., Rodland, M., Rusyn, I., Samson, L. D., Schwartz, D. A., Shi, Y., Shin, J. L., Sieber, S. O., Slifer, S., Speer, M. C., Spencer, P. S., Sproles, D. I., Swenberg, J. A., Suk, W. A., Sullivan, R. C., Tian, R., Tennant, R. W., Todd, S. A., Tucker, C. J., Van Houten, B., Weis, B. K., Xuan, S. & Zarbl, H., May 2005, In : Nature Methods. 2, 5, p. 1-6 6 p.

Research output: Contribution to journalArticle

387 Scopus citations
2004

Chromogenic and neurotoxic effects of an aliphatic γ-diketone: Computational insights into the molecular structures and mechanism

Zhan, C. G., Spencer, P. S. & Dixon, D. A., May 13 2004, In : Journal of Physical Chemistry B. 108, 19, p. 6098-6104 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Empirical evaluation of data transformations and ranking statistics for microarray analysis

Qin, L. X., Kerr, K. F., Boyles, A., Dressman, H. K., Freedman, J. H., Li, Y. J., Malek, R. L., Schwartz, D. A., Slifer, S., Speer, M. C., Yang, I., Zarbl, H., Shin, J. L., Jing, L., Sullivan, R. C., Fry, R., Samson, L., Tucker, C. J., Fannin, R. D., Sieber, S. O. & 27 others, Li, J., Bushel, P. R., Paules, R. S., Boorman, G. A., Cunningham, M. L., Weis, B. K., Choi, D., Lapidus, J., Lasarev, M., Lu, X., O'Malley, J., Pattee, P., Nagalla, S., Todd, S., Rodland, M., Spencer, P., Kaufmann, W., Perou, C., Rusyn, I., Swenberg, J., Bradford, B., Deng, S., Kavanagh, T. J., Farin, F. M., Beyer, R. P., Quigley, S. & Bammler, T. K., 2004, In : Nucleic acids research. 32, 18, p. 5471-5479 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Identification of Endogenous Phosphorylation Sites of Bovine Medium and Low Molecular Weight Neurofilament Proteins by Tandem Mass Spectrometry

Trimpin, S., Mixon, A. E., Stapels, M. D., Kim, M. Y., Spencer, P. S. & Deinzer, M. L., Feb 24 2004, In : Biochemistry. 43, 7, p. 2091-2105 15 p.

Research output: Contribution to journalArticle

24 Scopus citations
2003

Computational insights into the chemical structures and mechanisms of the chromogenic and neurotoxic effects of aromatic γ-diketones

Zhan, C. G., Spencer, P. & Dixon, D. A., Mar 27 2003, In : Journal of Physical Chemistry B. 107, 12, p. 2853-2861 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2002

Actions of pyridostigmine and organophosphate agents on chick cells, mice, and chickens

Wilson, B. W., Henderson, J. D., Coatney, E. M., Nieberg, P. S. & Spencer, P. S., May 16 2002, In : Drug and Chemical Toxicology. 25, 2, p. 131-139 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic γ-diketone that induces proximal neurofilamentous axonopathy

Kim, M. S., Hashemi, S. B., Spencer, P. S. & Sabri, M. I., Jan 1 2002, In : Toxicology and Applied Pharmacology. 183, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Aromatic as well as aliphatic hydrocarbon solvent axonopathy

Spencer, P. S., Kim, M. S. & Sabri, M. I., Jan 1 2002, In : International Journal of Hygiene and Environmental Health. 205, 1-2, p. 131-136 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

How does acrylamide perturb axon transport and induce nerve fiber degeneration? Commentary on forum position paper

Sabri, M. I. & Spencer, P. S., Jul 1 2002, In : NeuroToxicology. 23, 2, p. 259-263+265-270

Research output: Contribution to journalArticle

7 Scopus citations

Illness experience of Gulf War veterans possibly exposed to chemical warfare agents

McCauley, L. A., Lasarev, M., Sticker, D., Rischitelli, D. G. & Spencer, P. S., Oct 1 2002, In : American journal of preventive medicine. 23, 3, p. 200-206 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants

Zhan, C. G., Dixon, D. A., Sabri, M. I., Kim, M. S. & Spencer, P. S., Mar 20 2002, In : Journal of the American Chemical Society. 124, 11, p. 2744-2752 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
2001

1,2-Diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy

Kim, M. S., Sabri, M. I., Miller, V. H., Kayton, R. J., Dixon, D. A. & Spencer, P. S., Dec 1 2001, In : Toxicology and Applied Pharmacology. 177, 2, p. 121-131 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Self-reported exposures and their association with unexplained illness in a population-based case-control study of Gulf War Veterans

Spencer, P. S., McCauley, L. A., Lapidus, J. A., Lasarev, M., Joos, S. K. & Storzbach, D., Jan 1 2001, In : Journal of occupational and environmental medicine. 43, 12, p. 1041-1056 16 p.

Research output: Contribution to journalArticle

37 Scopus citations

Symptoms of gulf war veterans possibly exposed to organophosphate chemical warfare agents at Khamisiyah, Iraq

McCauley, L. A., Rischitelli, G., Lambert, W. E., Lasarev, M., Sticker, D. L. & Spencer, P. S., Jan 1 2001, In : International Journal of Occupational and Environmental Health. 7, 2, p. 79-89 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Treatment of skin injuries induced by sulfur mustard with Calmodulin antagonists, using the pig model

Kisby, G. E., Springer, N. & Spencer, P. S., Jul 14 2001, In : Journal of Applied Toxicology. 21, SUPPL. 1, p. S133-S136

Research output: Contribution to journalArticle

2000

Classification of neurotoxic responses based on vulnerability of cellular sites

Schaumburg, H. H. & Spencer, P. S., Jan 1 2000, In : Neurologic Clinics. 18, 3, p. 517-524 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

In Vitro neurotoxic and DNA-damaging properties of nitrogen mustard

Kisby, G. E., Springer, N. & Spencer, P. S., 2000, In : Journal of Applied Toxicology. 20, SUPPL. 1, p. S35-S41

Research output: Contribution to journalArticle

7 Scopus citations
1999

Back pain-related absenteeism: Differences between small and large companies

Butterfield, P. G., Spencer, P. S. & Yates, S., Dec 1 1999, Journal of Agricultural Safety and Health, 5, 2, p. 215-225 11 p.

Research output: Contribution to specialist publicationArticle

1 Scopus citations