Peter Barr-Gillespie

Professor

  • 6434 Citations
  • 45 h-Index
1988 …2019

Research output per year

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Research Output

2019

Molecular Composition of Vestibular Hair Bundles

Krey, J. F. & Barr-Gillespie, P., Jan 2 2019, In : Cold Spring Harbor perspectives in medicine. 9, 1

Research output: Contribution to journalReview article

1 Scopus citations
2018

Data Descriptor: Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells

Krey, J. F., Scheffer, D. I., Choi, D., Reddy, A., David, L. L., Corey, D. P. & Barr-Gillespie, P. G., Jul 17 2018, In : Scientific Data. 5, 180128.

Research output: Contribution to journalArticle

1 Scopus citations

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells

Krey, J. F., Dumont, R. A., Wilmarth, P., David, L., Johnson, K. R. & Barr-Gillespie, P., Jan 24 2018, In : Journal of Neuroscience. 38, 4, p. 843-857 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Honing In on TMC as the Hair Cell's Transduction Channel

Barr-Gillespie, P., Aug 22 2018, In : Neuron. 99, 4, p. 628-629 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails

Ellwanger, D. C., Scheibinger, M., Dumont, R. A., Barr-Gillespie, P. & Heller, S., Jun 5 2018, In : Cell Reports. 23, 10, p. 2901-2914.e14

Research output: Contribution to journalArticle

8 Scopus citations

TRPV6, TRPM6 and TRPM7 do not contribute to hair-cell mechanotransduction

Morgan, C. P., Zhao, H., LeMasurier, M., Xiong, W., Pan, B., Kazmierczak, P., Avenarius, M. R., Bateschell, M., Larisch, R., Ricci, A. J., Müller, U. & Barr-Gillespie, P. G., Feb 20 2018, In : Frontiers in Cellular Neuroscience. 12, 41.

Research output: Contribution to journalArticle

2 Scopus citations
2017

A Model for Link Pruning to Establish Correctly Polarized and Oriented Tip Links in Hair Bundles

Tompkins, N., Spinelli, K. J., Choi, D. & Barr-Gillespie, P., Oct 17 2017, In : Biophysical Journal. 113, 8, p. 1868-1881 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Analysis of the Proteome of Hair-Cell Stereocilia by Mass Spectrometry

Krey, J. F., Wilmarth, P., David, L. & Barr-Gillespie, P., 2017, Methods in Enzymology. Academic Press Inc., Vol. 585. p. 329-354 26 p. (Methods in Enzymology; vol. 585).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Corrigendum: Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like (Nature Communications, (2016), 7, 1, (10833), 10.1038/ncomms10833)

Ebrahim, S., Avenarius, M. R., Grati, M., Krey, J. F., Windsor, A. M., Sousa, A. D., Ballesteros, A., Cui, R., Millis, B. A., Salles, F. T., Baird, M. A., Davidson, M. W., Jones, S. M., Choi, D., Dong, L., Raval, M. H., Yengo, C. M., Barr-Gillespie, P. G. & Kachar, B., Dec 22 2017, In : Nature communications. 8, 1, 16133.

Research output: Contribution to journalComment/debate

1 Scopus citations

Heterodimeric capping protein is required for stereocilia length and width regulation

Avenarius, M. R., Krey, J. F., Dumont, R. A., Morgan, C. P., Benson, C. B., Vijayakumar, S., Cunningham, C. L., Scheffer, D. I., Corey, D. P., Müller, U., Jones, S. M. & Barr-Gillespie, P., Nov 1 2017, In : Journal of Cell Biology. 216, 11, p. 3861-3881 21 p.

Research output: Contribution to journalArticle

13 Scopus citations

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by transmembrane o-methyltransferase (Tomt)

Erickson, T., Morgan, C. P., Olt, J., Hardy, K., Busch-Nentwich, E., Maeda, R., Clemens, R., Krey, J. F., Nechiporuk, A., Barr-Gillespie, P. G., Marcotti, W. & Nicolson, T., May 23 2017, In : eLife. 6, e28474.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and Function

Krey, J. F., Drummond, M., Foster, S., Porsov, E., Vijayakumar, S., Choi, D., Friderici, K., Jones, S. M., Nuttall, A. L. & Barr-Gillespie, P. G., Jun 2 2016, In : Scientific Reports. 6, 27221.

Research output: Contribution to journalArticle

4 Scopus citations

Neuroplastin isoform Np55 is expressed in the stereocilia of outer hair cells and required for normal outer hair cell function

Zeng, W. Z., Grillet, N., Dewey, J. B., Trouillet, A., Krey, J. F., Barr-Gillespie, P., Oghalai, J. S. & Müller, U., Aug 31 2016, In : Journal of Neuroscience. 36, 35, p. 9201-9216 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

PDZD7-MYO7A complex identified in enriched stereocilia membranes

Morgan, C. P., Krey, J. F., Grati, M., Zhao, B., Fallen, S., Kannan-Sundhari, A., Liu, X. Z., Choi, D., Müller, U. & Barr-Gillespie, P. G., Aug 15 2016, In : eLife. 5, AUGUST, e18312.

Research output: Contribution to journalArticle

15 Scopus citations

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid

Krey, J. F., Krystofiak, E. S., Dumont, R. A., Vijayakumar, S., Choi, D., Rivero, F., Kachar, B., Jones, S. M. & Barr-Gillespie, P. G., 2016, In : Journal of Cell Biology. 215, 4, p. 467-482 16 p.

Research output: Contribution to journalArticle

18 Scopus citations
22 Scopus citations

Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

Ebrahim, S., Avenarius, M. R., Grati, M., Krey, J. F., Windsor, A. M., Sousa, A. D., Ballesteros, A., Cui, R., Millis, B. A., Salles, F. T., Baird, M. A., Davidson, M. W., Jones, S. M., Choi, D., Dong, L., Raval, M. H., Yengo, C. M., Barr-Gillespie, P. G. & Kachar, B., Mar 1 2016, In : Nature communications. 7, 10833.

Research output: Contribution to journalArticle

23 Scopus citations
2015

A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the xin repeats is required for maintenance of stereocilia morphology and hearing function

Francis, S. P., Krey, J. F., Krystofiak, E. S., Cui, R., Nanda, S., Xu, W., Kachar, B., Barr-Gillespie, P. G. & Shin, J. B., Jan 1 2015, In : Journal of Neuroscience. 35, 5, p. 1999-2014 16 p.

Research output: Contribution to journalArticle

29 Scopus citations

Assembly of hair bundles, an amazing problem for cell biology

Barr-Gillespie, P. G., Aug 1 2015, In : Molecular biology of the cell. 26, 15, p. 2727-2732 6 p.

Research output: Contribution to journalReview article

35 Scopus citations

Hair-bundle proteomes of avian and mammalian inner-ear utricles

Wilmarth, P. A., Krey, J. F., Shin, J. B., Choi, D., David, L. L. & Barr-Gillespie, P. G., Dec 8 2015, In : Scientific Data. 2, 150074.

Research output: Contribution to journalArticle

10 Scopus citations

New treatment options for hearing loss

Müller, U. & Barr-Gillespie, P. G., May 5 2015, In : Nature Reviews Drug Discovery. 14, 5, p. 346-365 20 p.

Research output: Contribution to journalReview article

68 Scopus citations

The proteome of mouse vestibular hair bundles over development

Krey, J. F., Sherman, N. E., Jeffery, E. D., Choi, D. & Barr-Gillespie, P., Sep 15 2015, In : Scientific data. 2, 150047.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Accurate label-free protein quantitation with high- and low-resolution mass spectrometers

Krey, J. F., Wilmarth, P. A., Shin, J. B., Klimek, J., Sherman, N. E., Jeffery, E. D., Choi, D., David, L. L. & Barr-Gillespie, P. G., Feb 7 2014, In : Journal of Proteome Research. 13, 2, p. 1034-1044 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Correlation of actin crosslinker and capper expression levels with stereocilia growth phases

Avenarius, M. R., Saylor, K. W., Lundeberg, M. R., Wilmarth, P. A., Shin, J. B., Spinelli, K. J., Pagana, J. M., Andrade, L., Kachar, B., Choi, D., David, L. L. & Barr-Gillespie, P. G., Feb 1 2014, In : Molecular and Cellular Proteomics. 13, 2, p. 606-620 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

The local forces acting on the mechanotransduction channel in hair cell stereocilia

Powers, R. J., Kulason, S., Atilgan, E., Brownell, W. E., Sun, S. X., Barr-Gillespie, P. G. & Spector, A. A., Jun 3 2014, In : Biophysical Journal. 106, 11, p. 2519-2528 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

Maeda, R., Kindt, K. S., Mo, W., Morgan, C. P., Erickson, T., Zhao, H., Clemens-Grisham, R., Barr-Gillespie, P. G. & Nicolson, T., Sep 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 35, p. 12907-12912 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Mechanotransduction: The elusive hair cell transduction channel revealed?

Morgan, C. P. & Barr-Gillespie, P. G., Oct 7 2013, In : Current Biology. 23, 19, p. R887-R890

Research output: Contribution to journalShort survey

8 Scopus citations

Molecular architecture of the chick vestibular hair bundle

Shin, J. B., Krey, J. F., Hassan, A., Metlagel, Z., Tauscher, A. N., Pagana, J. M., Sherman, N. E., Jeffery, E. D., Spinelli, K. J., Zhao, H., Wilmarth, P. A., Choi, D., David, L. L., Auer, M. & Barr-Gillespie, P. G., Mar 1 2013, In : Nature Neuroscience. 16, 3, p. 365-374 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

Indzhykulian, A. A., Stepanyan, R., Nelina, A., Spinelli, K. J., Ahmed, Z. M., Belyantseva, I. A., Friedman, T. B., Barr-Gillespie, P. G. & Frolenkov, G. I., Jun 2013, In : PLoS Biology. 11, 6, e1001583.

Research output: Contribution to journalArticle

64 Scopus citations

Who needs tip links? Backwards transduction by hair cells

Barr-Gillespie, P. G. & Nicolson, T., Nov 2013, In : Journal of General Physiology. 142, 5, p. 481-486 6 p.

Research output: Contribution to journalComment/debate

7 Scopus citations
2012

Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes

Zheng, Q. Y., Scarborough, J. D., Zheng, Y., Yu, H., Choi, D. & Gillespie, P. G., Jun 2012, In : Human molecular genetics. 21, 11, p. 2588-2598 11 p., dds084.

Research output: Contribution to journalArticle

14 Scopus citations
20 Scopus citations

Improved Biolistic Transfection of Hair Cells

Zhao, H., Avenarius, M. R. & Gillespie, P. G., Oct 1 2012, In : PloS one. 7, 10, e46765.

Research output: Contribution to journalArticle

6 Scopus citations

Large membrane domains in hair bundles specify spatially constricted radixin activation

Zhao, H., Williams, D. E., Shin, J. B., Brügger, B. & Gillespie, P. G., Mar 28 2012, In : Journal of Neuroscience. 32, 13, p. 4600-4609 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the usher syndrome protein network

Grati, M., Shin, J. B., Weston, M. D., Green, J., Bhat, M. A., Gillespie, P. G. & Kachar, B., Oct 10 2012, In : Journal of Neuroscience. 32, 41, p. 14288-14293 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Molecular Biology of Hearing and Balance

Krey, J. F. & Gillespie, P. G., Dec 1 2012, Basic Neurochemistry. Elsevier, p. 916-927 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Monitoring Intracellular Calcium Ion Dynamics in Hair Cell Populations with Fluo-4 AM

Spinelli, K. J. & Gillespie, P. G., Dec 17 2012, In : PloS one. 7, 12, e51874.

Research output: Contribution to journalArticle

14 Scopus citations

Probing the Cochlear Amplifier by Immobilizing Molecular Motors of Sensory Hair Cells

Ren, T. & Gillespie, P. G., Dec 6 2012, In : Neuron. 76, 5, p. 868-870 3 p.

Research output: Contribution to journalShort survey

Stereocilia membrane deformation: Implications for the gating spring and mechanotransduction channel

Powers, R. J., Roy, S., Atilgan, E., Brownell, W. E., Sun, S. X., Gillespie, P. G. & Spector, A. A., Jan 18 2012, In : Biophysical Journal. 102, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2011

Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42

Borck, G., Rehman, A. U., Lee, K., Pogoda, H. M., Kakar, N., Von Ameln, S., Grillet, N., Hildebrand, M. S., Ahmed, Z. M., Nürnberg, G., Ansar, M., Basit, S., Javed, Q., Morell, R. J., Nasreen, N., Shearer, A. E., Ahmad, A., Kahrizi, K., Shaikh, R. S., Ali, R. A. & 22 others, Khan, S. N., Goebel, I., Meyer, N. C., Kimberling, W. J., Webster, J. A., Stephan, D. A., Schiller, M. R., Bahlo, M., Najmabadi, H., Gillespie, P. G., Nürnberg, P., Wollnik, B., Riazuddin, S., Smith, R. J. H., Ahmad, W., Müller, U., Hammerschmidt, M., Friedman, T. B., Riazuddin, S., Leal, S. M., Ahmad, J. & Kubisch, C., Feb 11 2011, In : American Journal of Human Genetics. 88, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Measurement of cochlear power gain in the sensitive gerbil ear

Ren, T., He, W. & Gillespie, P. G., 2011, In : Nature communications. 2, 1, 216.

Research output: Contribution to journalArticle

38 Scopus citations

Myosin 1c participates in B cell cytoskeleton rearrangements, is recruited to the immunologic synapse, and contributes to antigen presentation

Maravillas-Montero, J. L., Gillespie, P. G., Patiño-López, G., Shaw, S. & Santos-Argumedo, L., Sep 15 2011, In : Journal of Immunology. 187, 6, p. 3053-3063 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity

Yang, Y., Dai, M., Wilson, T. M., Omelchenko, I., Klimek, J. E., Wilmarth, P. A., David, L. L., Nuttall, A. L., Gillespie, P. G. & Shi, X., 2011, In : PloS one. 6, 1, e16547.

Research output: Contribution to journalArticle

39 Scopus citations
2010

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

Shin, J. B., Longo-Guess, C. M., Gagnon, L. H., Saylor, K. W., Dumont, R. A., Spinelli, K. J., Pagana, J. M., Wilmarth, P. A., David, L. L., Gillespie, P. G. & Johnson, K. R., Jul 21 2010, In : Journal of Neuroscience. 30, 29, p. 9683-9694 12 p.

Research output: Contribution to journalArticle

83 Scopus citations
2009

Bottoms up: Transduction channels at tip link bases

Spinelli, K. J. & Gillespie, P. G., May 1 2009, In : Nature Neuroscience. 12, 5, p. 529-530 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells

Grillet, N., Xiong, W., Reynolds, A., Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Gillespie, P. G. & Müller, U., May 14 2009, In : Neuron. 62, 3, p. 375-387 13 p.

Research output: Contribution to journalArticle

106 Scopus citations

Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms

Gillespie, P. G. & Müller, U., Oct 2 2009, In : Cell. 139, 1, p. 33-44 12 p.

Research output: Contribution to journalReview article

238 Scopus citations

Twist-off purification of hair bundles

Shin, J. B., Pagana, J. & Gillespie, P. G., Jan 1 2009, Auditory and Vestibular Research: Methods and Protocols. Humana Press, p. 241-255 15 p. (Methods in Molecular Biology; vol. 493).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations