Peter Barr-Gillespie

Professor

  • 6103 Citations
  • 45 h-Index
1988 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1988 2019

2019

Molecular Composition of Vestibular Hair Bundles

Krey, J. F. & Barr-Gillespie, P., Jan 2 2019, In : Cold Spring Harbor perspectives in medicine. 9, 1

Research output: Contribution to journalReview article

Cellular Mechanotransduction
Stereocilia
Biochemistry
Vertebrates
Rats
2018

Data Descriptor: Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells

Krey, J. F., Scheffer, D. I., Choi, D., Reddy, A., David, L., Corey, D. P. & Barr-Gillespie, P., Jul 17 2018, In : Scientific data. 5, 180128.

Research output: Contribution to journalArticle

Mass Spectrometry
Descriptors
Digital differential analyzers
Mass spectrometry
Cells
3 Citations (Scopus)

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells

Krey, J. F., Dumont, R. A., Wilmarth, P., David, L., Johnson, K. R. & Barr-Gillespie, P., Jan 24 2018, In : Journal of Neuroscience. 38, 4, p. 843-857 15 p.

Research output: Contribution to journalArticle

Vestibular Hair Cells
Guanosine Triphosphate
Hydrolysis
ADP-Ribosylation Factors
Saccule and Utricle
1 Citation (Scopus)

Honing In on TMC as the Hair Cell's Transduction Channel

Barr-Gillespie, P., Aug 22 2018, In : Neuron. 99, 4, p. 628-629 2 p.

Research output: Contribution to journalShort survey

Inner Ear
Neurons
Proteins
4 Citations (Scopus)

Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails

Ellwanger, D. C., Scheibinger, M., Dumont, R. A., Barr-Gillespie, P. & Heller, S., Jun 5 2018, In : Cell Reports. 23, 10, p. 2901-2914.e14

Research output: Contribution to journalArticle

Morphogenesis
Gene expression
Cells
Trajectories
Gene Expression
1 Citation (Scopus)

TRPV6, TRPM6 and TRPM7 do not contribute to hair-cell mechanotransduction

Morgan, C. P., Zhao, H., LeMasurier, M., Xiong, W., Pan, B., Kazmierczak, P., Avenarius, M. R., Bateschell, M., Larisch, R., Ricci, A. J., Müller, U. & Barr-Gillespie, P., Feb 20 2018, In : Frontiers in Cellular Neuroscience. 12, 41.

Research output: Contribution to journalArticle

Hair
Auditory Hair Cells
Head Movements
Eukaryotic Cells
Inner Ear
2017

A Model for Link Pruning to Establish Correctly Polarized and Oriented Tip Links in Hair Bundles

Tompkins, N., Spinelli, K. J., Choi, D. & Barr-Gillespie, P., Oct 17 2017, In : Biophysical Journal. 113, 8, p. 1868-1881 14 p.

Research output: Contribution to journalArticle

Stereocilia
Space Simulation
Cochlea
Regeneration
2 Citations (Scopus)

Analysis of the Proteome of Hair-Cell Stereocilia by Mass Spectrometry

Krey, J. F., Wilmarth, P., David, L. & Barr-Gillespie, P., 2017, Methods in Enzymology. Academic Press Inc., Vol. 585. p. 329-354 26 p. (Methods in Enzymology; vol. 585).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stereocilia
Proteome
Hair
Mass spectrometry
Mass Spectrometry
1 Citation (Scopus)

Corrigendum: Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

Ebrahim, S., Avenarius, M. R., Grati, M., Krey, J. F., Windsor, A. M., Sousa, A. D., Ballesteros, A., Cui, R., Millis, B. A., Salles, F. T., Baird, M. A., Davidson, M. W., Jones, S. M., Choi, D., Dong, L., Raval, M. H., Yengo, C. M., Barr-Gillespie, P. & Kachar, B., Aug 14 2017, In : Nature Communications. 8, 1 p.

Research output: Contribution to journalComment/debate

Myosin Type III
Stereocilia
myosins
stairways
spacing
9 Citations (Scopus)

Heterodimeric capping protein is required for stereocilia length and width regulation

Avenarius, M. R., Krey, J. F., Dumont, R. A., Morgan, C. P., Benson, C. B., Vijayakumar, S., Cunningham, C. L., Scheffer, D. I., Corey, D. P., Müller, U., Jones, S. M. & Barr-Gillespie, P., Nov 1 2017, In : Journal of Cell Biology. 216, 11, p. 3861-3881 21 p.

Research output: Contribution to journalArticle

Stereocilia
Proteins
Actins
Pseudopodia
Electroporation
11 Citations (Scopus)

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by transmembrane o-methyltransferase (Tomt)

Erickson, T., Morgan, C. P., Olt, J., Hardy, K., Busch-Nentwich, E., Maeda, R., Clemens, R., Krey, J. F., Nechiporuk, A., Barr-Gillespie, P., Marcotti, W. & Nicolson, T., May 23 2017, In : eLife. 6, e28474.

Research output: Contribution to journalArticle

Methyltransferases
Zebrafish
Cells
Proteins
HEK293 Cells
2016
4 Citations (Scopus)

Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and Function

Krey, J. F., Drummond, M., Foster, S., Porsov, E., Vijayakumar, S., Choi, D., Friderici, K., Jones, S. M., Nuttall, A. & Barr-Gillespie, P., Jun 2 2016, In : Scientific Reports. 6, 27221.

Research output: Contribution to journalArticle

Stereocilia
Annexins
Hair
Membrane Proteins
Annexin A5
11 Citations (Scopus)

Neuroplastin isoform Np55 is expressed in the stereocilia of outer hair cells and required for normal outer hair cell function

Zeng, W. Z., Grillet, N., Dewey, J. B., Trouillet, A., Krey, J. F., Barr-Gillespie, P., Oghalai, J. S. & Müller, U., Aug 31 2016, In : Journal of Neuroscience. 36, 35, p. 9201-9216 16 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Stereocilia
Protein Isoforms
Tectorial Membrane
Cochlea
9 Citations (Scopus)

PDZD7-MYO7A complex identified in enriched stereocilia membranes

Morgan, C. P., Krey, J. F., Grati, M., Zhao, B., Fallen, S., Kannan-Sundhari, A., Liu, X. Z., Choi, D., Müller, U. & Barr-Gillespie, P., Aug 15 2016, In : eLife. 5, AUGUST, e18312.

Research output: Contribution to journalArticle

Stereocilia
Cells
Membranes
Deafness
Genes
14 Citations (Scopus)

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid

Krey, J. F., Krystofiak, E. S., Dumont, R. A., Vijayakumar, S., Choi, D., Rivero, F., Kachar, B., Jones, S. M. & Barr-Gillespie, P., 2016, In : Journal of Cell Biology. 215, 4, p. 467-482 16 p.

Research output: Contribution to journalArticle

Stereocilia
Actin Cytoskeleton
Actins
Inner Ear
Cell Surface Extensions
20 Citations (Scopus)
Outer Auditory Hair Cells
Interferometry
cochlea
Cochlea
Vibration
17 Citations (Scopus)

Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

Ebrahim, S., Avenarius, M. R., Grati, M., Krey, J. F., Windsor, A. M., Sousa, A. D., Ballesteros, A., Cui, R., Millis, B. A., Salles, F. T., Baird, M. A., Davidson, M. W., Jones, S. M., Choi, D., Dong, L., Raval, M. H., Yengo, C. M., Barr-Gillespie, P. & Kachar, B., Mar 1 2016, In : Nature Communications. 7, 10833.

Research output: Contribution to journalArticle

Myosin Type III
Stereocilia
myosins
cargo
stairways
2015
26 Citations (Scopus)

A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the xin repeats is required for maintenance of stereocilia morphology and hearing function

Francis, S. P., Krey, J. F., Krystofiak, E. S., Cui, R., Nanda, S., Xu, W., Kachar, B., Barr-Gillespie, P. & Shin, J. B., 2015, In : Journal of Neuroscience. 35, 5, p. 1999-2014 16 p.

Research output: Contribution to journalArticle

Stereocilia
Hearing
Actins
Maintenance
Inner Ear
27 Citations (Scopus)

Assembly of hair bundles, an amazing problem for cell biology

Barr-Gillespie, P., Aug 1 2015, In : Molecular Biology of the Cell. 26, 15, p. 2727-2732 6 p.

Research output: Contribution to journalArticle

Stereocilia
Inner Auditory Hair Cells
Cell Biology
Cytoskeletal Proteins
Systems Biology
9 Citations (Scopus)

Hair-bundle proteomes of avian and mammalian inner-ear utricles

Wilmarth, P., Krey, J. F., Shin, J. B., Choi, D., David, L. & Barr-Gillespie, P., Dec 8 2015, In : Scientific data. 2, 150074.

Research output: Contribution to journalArticle

Bundle
Proteins
Mouse
Peptides
Rats
54 Citations (Scopus)

New treatment options for hearing loss

Müller, U. & Barr-Gillespie, P., May 5 2015, In : Nature Reviews Drug Discovery. 14, 5, p. 346-365 20 p.

Research output: Contribution to journalArticle

Hearing Loss
Auditory Pathways
Genetic Loci
Hearing Aids
Cochlear Implants
19 Citations (Scopus)

The proteome of mouse vestibular hair bundles over development

Krey, J. F., Sherman, N. E., Jeffery, E. D., Choi, D. & Barr-Gillespie, P., Sep 15 2015, In : Scientific data. 2, 150047.

Research output: Contribution to journalArticle

Mouse
Bundle
Proteins
Protein
data acquisition
2014
51 Citations (Scopus)

Accurate label-free protein quantitation with high- and low-resolution mass spectrometers

Krey, J. F., Wilmarth, P., Shin, J. B., Klimek, J., Sherman, N. E., Jeffery, E. D., Choi, D., David, L. & Barr-Gillespie, P., Feb 7 2014, In : Journal of Proteome Research. 13, 2, p. 1034-1044 11 p.

Research output: Contribution to journalArticle

Mass spectrometers
Labels
Ions
Proteins
Tandem Mass Spectrometry
16 Citations (Scopus)

Correlation of actin crosslinker and capper expression levels with stereocilia growth phases

Avenarius, M. R., Saylor, K. W., Lundeberg, M. R., Wilmarth, P., Shin, J. B., Spinelli, K. J., Pagana, J. M., Andrade, L., Kachar, B., Choi, D., David, L. & Barr-Gillespie, P., Feb 2014, In : Molecular and Cellular Proteomics. 13, 2, p. 606-620 15 p.

Research output: Contribution to journalArticle

Stereocilia
Actins
Cochlea
Growth
Mass spectrometry
12 Citations (Scopus)

The local forces acting on the mechanotransduction channel in hair cell stereocilia

Powers, R. J., Kulason, S., Atilgan, E., Brownell, W. E., Sun, S. X., Barr-Gillespie, P. & Spector, A. A., Jun 3 2014, In : Biophysical Journal. 106, 11, p. 2519-2528 10 p.

Research output: Contribution to journalArticle

Stereocilia
Membranes
Cytoskeleton
Ion Channels
63 Citations (Scopus)

Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

Maeda, R., Kindt, K. S., Mo, W., Morgan, C. P., Erickson, T., Zhao, H., Clemens-Grisham, R., Barr-Gillespie, P. & Nicolson, T., Sep 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 35, p. 12907-12912 6 p.

Research output: Contribution to journalArticle

Zebrafish
Two-Hybrid System Techniques
Protein Isoforms
Auditory Hair Cells
Vestibular Hair Cells
8 Citations (Scopus)

Mechanotransduction: The elusive hair cell transduction channel revealed?

Morgan, C. P. & Barr-Gillespie, P., Oct 7 2013, In : Current Biology. 23, 19

Research output: Contribution to journalArticle

transmembrane proteins
Inner Ear
hairs
Vertebrates
ears
80 Citations (Scopus)

Molecular architecture of the chick vestibular hair bundle

Shin, J. B., Krey, J. F., Hassan, A., Metlagel, Z., Tauscher, A. N., Pagana, J. M., Sherman, N. E., Jeffery, E. D., Spinelli, K. J., Zhao, H., Wilmarth, P., Choi, D., David, L., Auer, M. & Barr-Gillespie, P., Mar 2013, In : Nature Neuroscience. 16, 3, p. 365-374 10 p.

Research output: Contribution to journalArticle

Actins
Mass Spectrometry
Proteins
Electron Microscope Tomography
Stereocilia
58 Citations (Scopus)

Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

Indzhykulian, A. A., Stepanyan, R., Nelina, A., Spinelli, K. J., Ahmed, Z. M., Belyantseva, I. A., Friedman, T. B., Barr-Gillespie, P. & Frolenkov, G. I., Jun 2013, In : PLoS Biology. 11, 6, e1001583.

Research output: Contribution to journalArticle

Auditory Hair Cells
Stereocilia
cadherins
Inner Auditory Hair Cells
hairs
7 Citations (Scopus)

Who needs tip links? Backwards transduction by hair cells

Barr-Gillespie, P. & Nicolson, T., Nov 2013, In : Journal of General Physiology. 142, 5, p. 481-486 6 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Organ of Corti
Deafness
Membrane Proteins
2012
13 Citations (Scopus)

Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes

Zheng, Q. Y., Scarborough, J. D., Zheng, Y., Yu, H., Choi, D. & Barr-Gillespie, P., Jun 2012, In : Human Molecular Genetics. 21, 11, p. 2588-2598 11 p., dds084.

Research output: Contribution to journalArticle

Deafness
Myosins
Alleles
Mutation
Hearing Loss
19 Citations (Scopus)
Energy Metabolism
Mass Spectrometry
Epithelium
Proteins
Oxidative Phosphorylation
6 Citations (Scopus)

Improved Biolistic Transfection of Hair Cells

Zhao, H., Avenarius, M. R. & Barr-Gillespie, P., Oct 1 2012, In : PLoS One. 7, 10, e46765.

Research output: Contribution to journalArticle

Biolistics
biolistics
transfection
hairs
Transfection
26 Citations (Scopus)

Large membrane domains in hair bundles specify spatially constricted radixin activation

Zhao, H., Williams, D. E., Shin, J. B., Brügger, B. & Barr-Gillespie, P., Mar 28 2012, In : Journal of Neuroscience. 32, 13, p. 4600-4609 10 p.

Research output: Contribution to journalArticle

Vestibular Hair Cells
Membranes
Stereocilia
Cell Membrane
Class 3 Receptor-Like Protein Tyrosine Phosphatases
35 Citations (Scopus)

Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the usher syndrome protein network

Grati, M., Shin, J. B., Weston, M. D., Green, J., Bhat, M. A., Barr-Gillespie, P. & Kachar, B., Oct 10 2012, In : Journal of Neuroscience. 32, 41, p. 14288-14293 6 p.

Research output: Contribution to journalArticle

Usher Syndromes
Stereocilia
PDZ Domains
Ankle
Proteins

Molecular Biology of Hearing and Balance

Krey, J. F. & Barr-Gillespie, P., 2012, Basic Neurochemistry. Elsevier, p. 916-927 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hearing
Molecular Biology
12 Citations (Scopus)

Monitoring Intracellular Calcium Ion Dynamics in Hair Cell Populations with Fluo-4 AM

Spinelli, K. J. & Barr-Gillespie, P., Dec 17 2012, In : PLoS One. 7, 12, e51874.

Research output: Contribution to journalArticle

hairs
Cells
Ions
ions
Calcium

Probing the Cochlear Amplifier by Immobilizing Molecular Motors of Sensory Hair Cells

Ren, T. & Barr-Gillespie, P., Dec 6 2012, In : Neuron. 76, 5, p. 868-870 3 p.

Research output: Contribution to journalArticle

Cochlea
Vibration
Neurons
27 Citations (Scopus)

Stereocilia membrane deformation: Implications for the gating spring and mechanotransduction channel

Powers, R. J., Roy, S., Atilgan, E., Brownell, W. E., Sun, S. X., Barr-Gillespie, P. & Spector, A. A., Jan 18 2012, In : Biophysical Journal. 102, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

Stereocilia
Membranes
Ion Channels
Outer Auditory Hair Cells
Rana catesbeiana
2011
62 Citations (Scopus)

Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42

Borck, G., Rehman, A. U., Lee, K., Pogoda, H. M., Kakar, N., Von Ameln, S., Grillet, N., Hildebrand, M. S., Ahmed, Z. M., Nürnberg, G., Ansar, M., Basit, S., Javed, Q., Morell, R. J., Nasreen, N., Shearer, A. E., Ahmad, A., Kahrizi, K., Shaikh, R. S., Ali, R. A. & 22 others, Khan, S. N., Goebel, I., Meyer, N. C., Kimberling, W. J., Webster, J. A., Stephan, D. A., Schiller, M. R., Bahlo, M., Najmabadi, H., Barr-Gillespie, P., Nürnberg, P., Wollnik, B., Riazuddin, S., Smith, R. J. H., Ahmad, W., Müller, U., Hammerschmidt, M., Friedman, T. B., Riazuddin, S., Leal, S. M., Ahmad, J. & Kubisch, C., Feb 11 2011, In : American Journal of Human Genetics. 88, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

Hearing Loss
Mutation
Initiator Codon
Nonsense Codon
Pakistan
34 Citations (Scopus)

Measurement of cochlear power gain in the sensitive gerbil ear

Ren, T., He, W. & Barr-Gillespie, P., 2011, In : Nature Communications. 2, 1, ncomms1226.

Research output: Contribution to journalArticle

power gain
Gerbillinae
Cochlea
ear
Ear
23 Citations (Scopus)

Myosin 1c participates in B cell cytoskeleton rearrangements, is recruited to the immunologic synapse, and contributes to antigen presentation

Maravillas-Montero, J. L., Barr-Gillespie, P., Patiño-López, G., Shaw, S. & Santos-Argumedo, L., Sep 15 2011, In : Journal of Immunology. 187, 6, p. 3053-3063 11 p.

Research output: Contribution to journalArticle

Antigen Presentation
Myosins
Cytoskeleton
Synapses
B-Lymphocytes
38 Citations (Scopus)

Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity

Yang, Y., Dai, M., Wilson, T. M., Omelchenko, I., Klimek, J. E., Wilmarth, P., David, L., Nuttall, A., Barr-Gillespie, P. & Shi, X., 2011, In : PLoS One. 6, 1, e16547.

Research output: Contribution to journalArticle

sodium-potassium-exchanging ATPase
Inner Ear
blood proteins
Adenosine Triphosphatases
Blood Proteins
Cochlea
Electric Impedance
Basilar Membrane
Beauty
Gerbillinae
2010
77 Citations (Scopus)

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

Shin, J. B., Longo-Guess, C. M., Gagnon, L. H., Saylor, K. W., Dumont, R. A., Spinelli, K. J., Pagana, J. M., Wilmarth, P., David, L., Barr-Gillespie, P. & Johnson, K. R., Jul 21 2010, In : Journal of Neuroscience. 30, 29, p. 9683-9694 12 p.

Research output: Contribution to journalArticle

Stereocilia
Inbred DBA Mouse
Hearing Loss
Hair
Actins
2009
6 Citations (Scopus)

Bottoms up: Transduction channels at tip link bases

Spinelli, K. J. & Barr-Gillespie, P., May 2009, In : Nature Neuroscience. 12, 5, p. 529-530 2 p.

Research output: Contribution to journalArticle

Stereocilia
Cochlea
95 Citations (Scopus)

Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells

Grillet, N., Xiong, W., Reynolds, A., Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Barr-Gillespie, P. & Müller, U., May 14 2009, In : Neuron. 62, 3, p. 375-387 13 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Cadherins
Stereocilia
Mutation
PDZ Domains
215 Citations (Scopus)

Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms

Barr-Gillespie, P. & Müller, U., Oct 2 2009, In : Cell. 139, 1, p. 33-44 12 p.

Research output: Contribution to journalArticle

Cells
Molecules
Machinery
Head Movements
Mechanoreceptors
5 Citations (Scopus)

Twist-off purification of hair bundles

Shin, J. B., Pagana, J. & Barr-Gillespie, P., 2009, Methods in Molecular Biology. Humana Press, Vol. 493. p. 241-255 15 p. (Methods in Molecular Biology; vol. 493).

Research output: Chapter in Book/Report/Conference proceedingChapter

Inner Ear
Sepharose
Immunoblotting
Dissection
Polyacrylamide Gel Electrophoresis