Ninian Blackburn

Professor

  • 5324 Citations
  • 47 h-Index
1975 …2020
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Research Output 1975 2019

  • 5324 Citations
  • 47 h-Index
  • 121 Article
  • 1 Chapter
  • 1 Conference contribution
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Article
2006
17 Citations (Scopus)

Role for an essential tyrosine in peptide amidation

De, M., Bell, J., Blackburn, N., Mains, R. E. & Eipper, B. A., Jul 28 2006, In : Journal of Biological Chemistry. 281, 30, p. 20873-20882 10 p.

Research output: Contribution to journalArticle

Lyases
Tyrosine
Catalytic Domain
Iron
Peptides
32 Citations (Scopus)

The catalytic role of the copper ligand H172 of peptidylglycine α-hydroxylating monooxygenase: A kinetic study of the H172A mutant

Evans, J. P., Blackburn, N. & Klinman, J. P., Dec 26 2006, In : Biochemistry. 45, 51, p. 15419-15429 11 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Isotopes
Copper
Electrons
Ligands
45 Citations (Scopus)

The hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a Cu(II)-superoxo catalytic intermediate

Bauman, A. T., Yukl, E. T., Alkevich, K., McCormack, A. L. & Blackburn, N., Feb 17 2006, In : Journal of Biological Chemistry. 281, 7, p. 4190-4198 9 p.

Research output: Contribution to journalArticle

Peroxides
Hydrogen Peroxide
Oxygen
Labels
Glucose Oxidase
2005
25 Citations (Scopus)

Cysteine-to-serine mutants of the human copper chaperone for superoxide dismutase reveal a copper cluster at a domain III dimer interface

Stasser, J. P., Eisses, J. F., Barry, A. N., Kaplan, J. H. & Blackburn, N., Mar 8 2005, In : Biochemistry. 44, 9, p. 3143-3152 10 p.

Research output: Contribution to journalArticle

Dimers
Serine
Superoxide Dismutase
Cysteine
Copper
24 Citations (Scopus)

Heme-copper/dioxygen adduct formation relevant to cytochrome c oxidase: Spectroscopic characterization of [(6L)FeIII-(O 2 2-)-CuII]+

Ghiladi, R. A., Huang, H. W., Moenne-Loccoz, P., Stasser, J., Blackburn, N., Woods, A. S., Cotter, R. J., Incarvito, C. D., Rheingold, A. L. & Karlin, K. D., Jan 2005, In : Journal of Biological Inorganic Chemistry. 10, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Heme
Copper
Oxygen
Pyrroles
48 Citations (Scopus)
Fungal Proteins
Mitochondrial Proteins
Bacilli
Bacillus subtilis
X-Ray Absorption Spectroscopy
3 Citations (Scopus)

Structure and coordination of CuB in the Acidianus ambivalens aa3 quinol oxidase heme-copper center

Bandeiras, T. M., Pereira, M. M., Teixeira, M., Moenne-Loccoz, P. & Blackburn, N., Oct 2005, In : Journal of Biological Inorganic Chemistry. 10, 6, p. 625-635 11 p.

Research output: Contribution to journalArticle

Acidianus
Carbon Monoxide
Heme
Copper
Extended X ray absorption fine structure spectroscopy
35 Citations (Scopus)

The catalytic copper of peptidylglycine α-hydroxylating monooxygenase also plays a critical structural role

Siebert, X., Eipper, B. A., Mains, R. E., Prigge, S. T., Blackburn, N. & Amzel, L. M., Nov 2005, In : Biophysical Journal. 89, 5, p. 3312-3319 8 p.

Research output: Contribution to journalArticle

Copper
Enzymes
Ligands
Enzyme Stability
Mutation
2004
37 Citations (Scopus)
X-Ray Absorption Spectroscopy
X ray absorption spectroscopy
Copper
Metals
Ligands
91 Citations (Scopus)

The N-terminal Metal-binding Site 2 of the Wilson's Disease Protein Plays a Key Role in the Transfer of Copper from Atox1

Walker, J. M., Huster, D., Ralle, M., Morgan, C. T., Blackburn, N. & Lutsenko, S., Apr 9 2004, In : Journal of Biological Chemistry. 279, 15, p. 15376-15384 9 p.

Research output: Contribution to journalArticle

Copper
Metals
Binding Sites
Cysteine
Wilson disease protein
54 Citations (Scopus)

The selenocysteine-substituted blue copper center: Spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin

Ralle, M., Berry, S. M., Nilges, M. J., Gieselman, M. D., Van Der Donk, W. A., Lu, Y. & Blackburn, N., Jun 16 2004, In : Journal of the American Chemical Society. 126, 23, p. 7244-7256 13 p.

Research output: Contribution to journalArticle

Azurin
Selenocysteine
Pseudomonas aeruginosa
Copper
Proteins
2003
59 Citations (Scopus)

Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine α-hydroxylating monooxygenase: Mechanistic implications

Francisco, W. A., Blackburn, N. & Klinman, J. P., Feb 25 2003, In : Biochemistry. 42, 7, p. 1813-1819 7 p.

Research output: Contribution to journalArticle

Oxygen Isotopes
Mixed Function Oxygenases
Phenylalanine
Isotopes
Tyrosine
80 Citations (Scopus)

Probing the role of axial methionine in the blue copper center of azurin with unnatural amino acids

Berry, S. M., Ralle, M., Low, D. W., Blackburn, N. & Lu, Y., Jul 23 2003, In : Journal of the American Chemical Society. 125, 29, p. 8760-8768 9 p.

Research output: Contribution to journalArticle

Azurin
Methionine
Amino acids
Copper
Hydrophobic and Hydrophilic Interactions
60 Citations (Scopus)

SpaC and NisC, the Cyclases Involved in Subtilin and Nisin Biosynthesis, Are Zinc Proteins

Okeley, N. M., Paul, M., Stasser, J. P., Blackburn, N. & Van Der Donk, W. A., Nov 25 2003, In : Biochemistry. 42, 46, p. 13613-13624 12 p.

Research output: Contribution to journalArticle

Nisin
Bacteriocins
Biosynthesis
Zinc
Multienzyme Complexes
101 Citations (Scopus)
X-Ray Absorption Spectroscopy
Phosphines
X ray absorption spectroscopy
Sulfhydryl Compounds
Copper
2002
109 Citations (Scopus)

Hydrogen tunneling in peptidylglycine α-hydroxylating monooxygenase

Francisco, W. A., Knapp, M. J., Blackburn, N. & Klinman, J. P., Jul 17 2002, In : Journal of the American Chemical Society. 124, 28, p. 8194-8195 2 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Isotopes
Hydrogen
Lipoxygenase
Vibration control
25 Citations (Scopus)

The catalytic role of the copper ligand H172 of peptidylglycine α-hydroxylating monooxygenase (PHM): A spectroscopic study of the H172A mutant

Jaron, S., Mains, R. E., Eipper, B. A. & Blackburn, N., Nov 5 2002, In : Biochemistry. 41, 44, p. 13274-13282 9 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Mixed Function Oxygenases
Copper
Ligands
Binding Sites
2001
23 Citations (Scopus)

Characterization of a half-apo derivative of peptidylglycine monooxygenase. Insight into the reactivity of each active site copper

Jaron, S. & Blackburn, N., Jun 12 2001, In : Biochemistry. 40, 23, p. 6867-6875 9 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Copper
Catalytic Domain
Derivatives
Enzymes
18 Citations (Scopus)

Isocyanide binding to the copper(I) centers of the catalytic core of peptidylglycine monooxygenase (PHMcc)

Rhames, F. C., Murthy, N. N., Karlin, K. D. & Blackburn, N., 2001, In : Journal of Biological Inorganic Chemistry. 6, 5-6, p. 567-577 11 p.

Research output: Contribution to journalArticle

Cyanides
Copper
Catalytic Domain
Fourier Transform Infrared Spectroscopy
Carbon Monoxide
2000
53 Citations (Scopus)

Domains I and III of the human copper chaperone for superoxide dismutase interact via a cysteine-bridged dicopper(I) cluster

Eisses, J. F., Stasser, J. P., Ralle, M., Kaplan, J. H. & Blackburn, N., Jun 27 2000, In : Biochemistry. 39, 25, p. 7337-7342 6 p.

Research output: Contribution to journalArticle

Superoxide Dismutase
Cysteine
Copper
Dithionite
Fourier Analysis
91 Citations (Scopus)
Copper
X-Ray Absorption Spectroscopy
Electrons
Ligands
X ray absorption spectroscopy
58 Citations (Scopus)

Spectroscopic analysis of the trinuclear cluster in the Fet3 protein from yeast, a multinuclear copper oxidase

Blackburn, N., Ralle, M., Hassett, R. & Kosman, D. J., Mar 7 2000, In : Biochemistry. 39, 9, p. 2316-2324 9 p.

Research output: Contribution to journalArticle

Fungal Proteins
Spectroscopic analysis
Cluster Analysis
Copper
Ceruloplasmin
1999
66 Citations (Scopus)

Does superoxide channel between the copper centers in peptidylglycine monooxygenase? A new mechanism based on carbon monoxide reactivity

Jaron, S. & Blackburn, N., Nov 16 1999, In : Biochemistry. 38, 46, p. 15086-15096 11 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Superoxides
Copper
Peptides
Fourier Transform Infrared Spectroscopy
28 Citations (Scopus)

Selenomethionine-substituted Thermus thermophilus cytochrome ba3: Characterization of the Cu(A) site by Se and Cu K-EXAFS

Blackburn, N., Ralle, M., Gomez, E., Hill, M. G., Pastuszyn, A., Sanders, D. & Fee, J. A., Jun 1 1999, In : Biochemistry. 38, 22, p. 7075-7084 10 p.

Research output: Contribution to journalArticle

Selenomethionine
Thermus thermophilus
Methionine
Proteins
Genes
107 Citations (Scopus)

The Cu(A) domain of Thermus thermophilus ba3-type cytochrome C oxidase at 1.6 Å resolution

Williams, P. A., Blackburn, N., Sanders, D., Bellamy, H., Stura, E. A., Fee, J. A. & McRee, D. E., 1999, In : Nature Structural Biology. 6, 6, p. 509-516 8 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Electron Transport Complex IV
Copper
Oxidoreductases
Histidine
1998
47 Citations (Scopus)

Heterobinucleating ligand-induced structural and chemical variations in [(L)Fe(III)-O-Cu(II)]+ μ-oxo complexes [9]

Obias, H. V., Van Strijdonck, G. P. F., Lee, D. H., Ralle, M., Blackburn, N. & Karlin, K. D., Sep 23 1998, In : Journal of the American Chemical Society. 120, 37, p. 9696-9697 2 p.

Research output: Contribution to journalArticle

Ligands
75 Citations (Scopus)

Kinetic mechanism and intrinsic isotope effects for the peptidylglycine α-amidating enzyme reaction

Francisco, W. A., Merkler, D. J., Blackburn, N. & Klinman, J. P., Jun 2 1998, In : Biochemistry. 37, 22, p. 8244-8252 9 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Isotopes
Kinetics
Enzymes
Dopamine
164 Citations (Scopus)

Peroxo-, oxo-, and hydroxo-bridged dicopper complexes: Observation of exogenous hydrocarbon substrate oxidation [3]

Obias, H. V., Lin, Y., Murthy, N. N., Pidcock, E., Solomon, E. I., Ralle, M., Blackburn, N., Neuhold, Y. M., Zuberbuhler, A. D. & Karlin, K. D., Dec 16 1998, In : Journal of the American Chemical Society. 120, 49, p. 12960-12961 2 p.

Research output: Contribution to journalArticle

Hydrocarbons
Oxidation
Substrates
40 Citations (Scopus)

Purification and characterization of laccases from the white-rot basidiomycete Dichomitus squalens

Périé, F. H., Reddy, G. V. B., Blackburn, N. & Gold, M. H., May 15 1998, In : Archives of Biochemistry and Biophysics. 353, 2, p. 349-355 7 p.

Research output: Contribution to journalArticle

Laccase
Basidiomycota
Purification
Copper
Azides
62 Citations (Scopus)

Spectroscopic Characterization of an Engineered Purple CuA Center in Azurin

Hay, M. T., Ang, M. C., Camelin, D. R., Solomon, E. I., Antholine, W. E., Ralle, M., Blackburn, N., Massey, P. D., Wang, X., Kwon, A. H. & Lu, Y., 1998, In : Inorganic Chemistry. 37, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

Azurin
Copper
Absorption spectra
copper
Paramagnetic resonance
58 Citations (Scopus)

The menkes disease protein binds copper via novel 2-coordinate Cu(I)- cysteinates in the N-terminal domain [7]

Ralle, M., Cooper, M. J., Lutsenko, S. & Blackburn, N., Dec 30 1998, In : Journal of the American Chemical Society. 120, 51, p. 13525-13526 2 p.

Research output: Contribution to journalArticle

Menkes Kinky Hair Syndrome
Copper
Proteins
5 Citations (Scopus)

XAS Studies on the CuA Centers of Heme-Copper Oxidases and Loop-Directed Mutants of Azurin: Implications for Redox Reactivity

Blackburn, N., Ralle, M., Sanders, D., Fee, J. A., De Vries, S., Houser, R. P., Tolman, W. B., Hay, M. T. & Lu, Y., 1998, In : ACS Symposium Series. 692, p. 241-259 19 p.

Research output: Contribution to journalArticle

Azurin
Heme
Protons
Oxygen
Copper
1997
27 Citations (Scopus)

Structural and functional investigations on the role of zinc in bifunctional rat peptidylglycine α-amidating enzyme

Bell, J., Ash, D. E., Snyder, L. M., Kulathila, R., Blackburn, N. & Merkler, D. J., 1997, In : Biochemistry. 36, 51, p. 16239-16246 8 p.

Research output: Contribution to journalArticle

Dealkylation
Zinc
Rats
Enzymes
Edetic Acid
86 Citations (Scopus)

X-ray absorption studies on the mixed-valence and fully reduced forms of the soluble Cu(A) domains of cytochrome c oxidase

Blackburn, N., De Vries, S., Barr, M. E., Houser, R. P., Tolman, W. B., Sanders, D. & Fee, J. A., 1997, In : Journal of the American Chemical Society. 119, 26, p. 6135-6143 9 p.

Research output: Contribution to journalArticle

X ray absorption
Bond length
Electron Transport Complex IV
X-Ray Absorption Spectroscopy
Metals
1996
88 Citations (Scopus)

Structural investigations on the coordination environment of the active- site copper centers of recombinant bifunctional peptidylglycine α-amidating enzyme

Boswell, J. S., Reedy, B. J., Kulathila, R., Merkler, D. & Blackburn, N., 1996, In : Biochemistry. 35, 38, p. 12241-12250 10 p.

Research output: Contribution to journalArticle

Copper
Catalytic Domain
Ligands
Enzymes
Carbon Monoxide
74 Citations (Scopus)

XAS structural comparisons of reversibly interconvertible oxo- and hydroxo-bridged heme-copper oxidase model compounds

Fox, S., Nanthakumar, A., Wikström, M., Karlin, K. D. & Blackburn, N., Jan 10 1996, In : Journal of the American Chemical Society. 118, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

X-Ray Absorption Spectroscopy
X ray absorption spectroscopy
Multiple scattering
Heme
Deprotonation
1995
32 Citations (Scopus)
Cyanides
Mixed Function Oxygenases
Copper
Dopamine
Ligands
87 Citations (Scopus)
X ray analysis
Electron Transport Complex IV
Molecular Structure
Complexation
Electron energy levels
93 Citations (Scopus)

Structure of CuB in the binuclear heme-copper center of the cytochrome aa3-type quinol oxidase from Bacillus subtilis: An ENDOR and EXAFS study

Fann, Y. C., Ahmed, I., Blackburn, N., Boswell, J. S., Verkhovskaya, M. L., Hoffman, B. M. & Wikström, M., 1995, In : Biochemistry. 34, 32, p. 10245-10255 11 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Electron Transport Complex IV
Bacilli
Bacillus subtilis
Heme
94 Citations (Scopus)

The catalytic core of peptidylglycine α-hydroxylating monooxygenase: Investigation by site-directed mutagenesis, Cu X-ray absorption spectroscopy, and electron paramagnetic resonance

Eipper, B. A., Quon, A. S. W., Mains, R. E., Boswell, J. S. & Blackburn, N., 1995, In : Biochemistry. 34, 9, p. 2857-2865 9 p.

Research output: Contribution to journalArticle

X-Ray Absorption Spectroscopy
Mutagenesis
X ray absorption spectroscopy
Electron Spin Resonance Spectroscopy
Mixed Function Oxygenases
1994
136 Citations (Scopus)
Electron Transport Complex IV
Copper
Metals
Structural Models
X ray absorption
82 Citations (Scopus)
Fourier Transform Infrared Spectroscopy
Binding sites
Mixed Function Oxygenases
Sulfur
Dopamine
1993
91 Citations (Scopus)

Chemistry and structural studies on the dioxygen-binding copper-1,2-dimethylimidazole system

Sanyal, I., Karlin, K. D., Strange, R. W. & Blackburn, N., 1993, In : Journal of the American Chemical Society. 115, 24, p. 11259-11270 12 p.

Research output: Contribution to journalArticle

Copper
Oxygen
X-Ray Absorption Spectroscopy
Phosphines
X ray absorption spectroscopy
Phenylalanine Hydroxylase
Dithionite
Biochemistry
X ray absorption
Copper
52 Citations (Scopus)

Oxo- and hydroxo-bridged (porphyrin)iron(III)-copper(II) species as cytochrome c oxidase models: Acid-base interconversions and X-ray structure of the Fe(III)-(O2-)-Cu(II) complex

Nanthakumar, A., Fox, S., Murthy, N. N., Karlin, K. D., Ravi, N., Huynh, B. H., Orosz, R. D., Day, E. P., Hagen, K. S. & Blackburn, N., Sep 8 1993, In : Journal of the American Chemical Society. 115, 18, p. 8513-8514 2 p.

Research output: Contribution to journalArticle

Porphyrins
Electron Transport Complex IV
Copper
Iron
X-Rays
1992
17 Citations (Scopus)

Identification of the cyanide stretching frequency in the cyano derivative of Cu/Zn-superoxide dismutase by IR and Raman spectroscopy

Han, J., Blackburn, N. & Loehr, T. M., 1992, In : Inorganic Chemistry. 31, 15, p. 3223-3229 7 p.

Research output: Contribution to journalArticle

inorganic peroxides
Cyanides
cyanides
Stretching
Raman spectroscopy
63 Citations (Scopus)

New thermally stable hydroperoxo- and peroxo-copper complexes

Mahroof-Tahir, M., Murthy, N. N., Karlin, K. D., Blackburn, N., Shaikh, S. N. & Zubieta, J., 1992, In : Inorganic Chemistry. 31, 14, p. 3001-3003 3 p.

Research output: Contribution to journalArticle

copper
19 Citations (Scopus)
Chromobacterium
Phenylalanine Hydroxylase
Dithionite
X ray absorption
Histidine
1991
56 Citations (Scopus)

Carbonmonoxy dopamine β-hydroxylase: Structural characterization by fourier transform infrared, fluorescence, and X-ray absorption spectroscopy

Pettingill, T. M., Strange, R. W. & Blackburn, N., Sep 15 1991, In : Journal of Biological Chemistry. 266, 26, p. 16996-17003 8 p.

Research output: Contribution to journalArticle

X-Ray Absorption Spectroscopy
X ray absorption spectroscopy
Fourier Analysis
Carbon Monoxide
Mixed Function Oxygenases
93 Citations (Scopus)

Copper K-extended X-ray absorption fine structure studies of oxidized and reduced dopamine β-hydroxylase: Confirmation of a sulfur ligand to copper(I) in the reduced enzyme

Blackburn, N., Hasnain, S. S., Pettingill, T. M. & Strange, R. W., Dec 5 1991, In : Journal of Biological Chemistry. 266, 34, p. 23120-23127 8 p.

Research output: Contribution to journalArticle

X ray absorption
Mixed Function Oxygenases
Sulfur
Copper
Dopamine