Nancy Haigwood

Professor

  • 6457 Citations
  • 44 h-Index
1976 …2019

Research output per year

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Research Output

2019

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge

Pegu, A., Borate, B., Huang, Y., Pauthner, M. G., Hessell, A. J., Julg, B., Doria-Rose, N. A., Schmidt, S. D., Carpp, L. N., Cully, M. D., Chen, X., Shaw, G. M., Barouch, D. H., Haigwood, N. L., Corey, L., Burton, D. R., Roederer, M., Gilbert, P. B., Mascola, J. R. & Huang, Y., Sep 11 2019, In : Cell Host and Microbe. 26, 3, p. 336-346.e3

Research output: Contribution to journalArticle

2 Scopus citations

Antibodies Tip the Balance Towards an HIV Cure

Haigwood, N. & Hessell, A., May 1 2019, In : Trends in Immunology. 40, 5, p. 375-377 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Divergent HIV-1-directed immune responses generated by systemic and mucosal immunization with replicating single-cycle adenoviruses in rhesus macaques

Matchett, W. E., Anguiano-Zarate, S. S., Nehete, P. N., Shelton, K., Nehete, B. P., Yang, G., Dorta-Estremera, S., Barnette, P., Xiao, P., Byrareddy, S. N., Villinger, F., Hessell, A., Haigwood, N., Sastry, K. J. & Barry, M. A., May 1 2019, In : Journal of virology. 93, 10, e02016-18.

Research output: Contribution to journalArticle

2 Scopus citations

Human natural killer cells mediate adaptive immunity to viral antigens

Nikzad, R., Angelo, L. S., Aviles-Padilla, K., Le, D. T., Singh, V. K., Bimler, L., Vukmanovic-Stejic, M., Vendrame, E., Ranganath, T., Simpson, L., Haigwood, N. L., Blish, C. A., Akbar, A. N. & Paust, S., Jan 1 2019, In : Science Immunology. 4, 35, eaat8116.

Research output: Contribution to journalArticle

20 Scopus citations

IL-33 enhances the kinetics and quality of the antibody response to a DNA and protein-based HIV-1 Env vaccine

Sarkar, S., Piepenbrink, M. S., Basu, M., Thakar, J., Keefer, M. C., Hessell, A. J., Haigwood, N. L. & Kobie, J. J., Apr 17 2019, In : Vaccine. 37, 17, p. 2322-2330 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses

Hessell, A., Powell, R., Jiang, X., Luo, C., Weiss, S., Dussupt, V., Itri, V., Fox, A., Shapiro, M. B., Pandey, S., Cheever, T., Fuller, D. H., Park, B., Krebs, S. J., Totrov, M., Haigwood, N., Kong, X. P. & Zolla-Pazner, S., Jul 23 2019, In : Cell Reports. 28, 4, p. 877-895.e6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Simian-human immunodeficiency virus SHIV.CH505 infection of rhesus macaques results in persistent viral replication and induces intestinal immunopathology

Bar, K. J., Coronado, E., Hensley-McBain, T., O’Connor, M. A., Osborn, J. M., Miller, C., Gott, T. M., Wangari, S., Iwayama, N., Ahrens, C. Y., Smedley, J., Moats, C., Lynch, R. M., Haddad, E. K., Haigwood, N., Fuller, D. H., Shaw, G. M., Klatt, N. R. & Manuzakb, J. A., Sep 1 2019, In : Journal of virology. 93, 18, e00372-19.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Antibodies pose a double threat to HIV

Haigwood, N., Sep 1 2018, In : Nature. 561, 7724, p. 468-470 3 p.

Research output: Contribution to journalComment/debate

Combination adenovirus and protein vaccines prevent infection or reduce viral burden after heterologous clade C simian-human immunodeficiency virus mucosal challenge

Malherbe, D. C., Mendy, J., Vang, L., Barnette, P. T., Reed, J., Lakhashe, S. K., Owuor, J., Gach, J. S., Legasse, A. W., Axthelm, M. K., LaBranche, C. C., Montefiori, D., Forthal, D. N., Park, B., Wilson, J. M., McLinden, J. H., Xiang, J., Stapleton, J. T., Sacha, J. B., Haynes, B. F. & 6 others, Liao, H. X., Ruprecht, R. M., Smith, J., Gurwith, M., Haigwood, N. L. & Alexander, J., Jan 1 2018, In : Journal of virology. 92, 2, e01092-17.

Research output: Contribution to journalArticle

10 Scopus citations

Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials

Balasubramanian, P., Williams, C., Shapiro, M. B., Sinangil, F., Higgins, K., Nádas, A., Totrov, M., Kong, X. P., Fiore-Gartland, A. J., Haigwood, N., Zolla-Pazner, S. & Hioe, C. E., Dec 1 2018, In : Scientific Reports. 8, 1, 18863.

Research output: Contribution to journalArticle

7 Scopus citations

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth

Chukwuma, V. U., Kose, N., Noah Sather, D., Sapparapu, G., King, H., Singh, V., Lampley, R., Malherbe, D. C., Ditto, N. T., Sullivan, J. T., Barnes, T., Doranz, B. J., Labranche, C. C., Montefiori, D. C., Kalams, S. A., Haigwood, N. L. & Crowe, J. E., Dec 2018, In : PloS one. 13, 12, e0209437.

Research output: Contribution to journalArticle

3 Scopus citations

Passive and active antibody studies in primates to inform HIV vaccines

Hessell, A., Malherbe, D. & Haigwood, N., Feb 1 2018, In : Expert Review of Vaccines. 17, 2, p. 127-144 18 p.

Research output: Contribution to journalReview article

9 Scopus citations

Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated simian/human immunodeficiency virus challenges

Hessell, A. J., Shapiro, M. B., Powell, R., Malherbe, D. C., McBurney, S. P., Pandey, S., Cheever, T., Sutton, W. F., Kahl, C., Park, B., Zolla-Pazner, S. & Haigwood, N. L., Jun 1 2018, In : Journal of virology. 92, 11, e02198-17.

Research output: Contribution to journalArticle

14 Scopus citations

Tribute to Bonnie Mathieson

Haigwood, N. & Schultz, A., Oct 1 2018, In : Journal of Medical Primatology. 47, 5, p. 286-287 2 p.

Research output: Contribution to journalArticle

2017

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques /631/326/596/1550 /631/326/596/2555 /631/326/596/2557 article

Burwitz, B. J., Wettengel, J. M., Mück-Häusl, M. A., Ringelhan, M., Ko, C., Festag, M. M., Hammond, K. B., Northrup, M., Bimber, B. N., Jacob, T., Reed, J. S., Norris, R., Park, B., Moller-Tank, S., Esser, K., Greene, J. M., Wu, H. L., Abdulhaqq, S., Webb, G., Sutton, W. F. & 8 others, Klug, A., Swanson, T., Legasse, A. W., Vu, T. Q., Asokan, A., Haigwood, N. L., Protzer, U. & Sacha, J. B., Dec 1 2017, In : Nature communications. 8, 1, 2146.

Research output: Contribution to journalArticle

14 Scopus citations

Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Envspecific antibody response in SHIV-infected rhesus macaques

Jaworski, J. P., Bryk, P., Brower, Z., Zheng, B., Hessell, A., Rosenberg, A. F., Wu, T. T., Sanz, I., Keefer, M. C., Haigwood, N. & Kobie, J. J., Feb 1 2017, In : PLoS One. 12, 2, e0172524.

Research output: Contribution to journalArticle

2 Scopus citations

Use of broadly neutralizing antibodies for HIV-1 prevention

Pegu, A., Hessell, A., Mascola, J. R. & Haigwood, N., Jan 1 2017, In : Immunological Reviews. 275, 1, p. 296-312 17 p.

Research output: Contribution to journalReview article

63 Scopus citations
2016

Achieving potent autologous neutralizing antibody responses against tier 2 HIV-1 viruses by strategic selection of envelope immunogens

Hessell, A. J., Malherbe, D. C., Pissani, F., McBurney, S., Krebs, S. J., Gomes, M., Pandey, S., Sutton, W. F., Burwitz, B. J., Gray, M., Robins, H., Park, B. S., Sacha, J. B., La Branche, C. C., Fuller, D. H., Montefiori, D. C., Stamatatos, L., Sather, D. N. & Haigwood, N. L., Apr 1 2016, In : Journal of Immunology. 196, 7, p. 3064-3078 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Differential induction of anti-V3 crown antibodies with cradle- and ladle-binding modes in response to HIV-1 envelope vaccination

Balasubramanian, P., Kumar, R., Williams, C., Itri, V., Wang, S., Lu, S., Hessell, A., Haigwood, N., Sinangil, F., Higgins, K. W., Liu, L., Li, L., Nyambi, P., Gorny, M. K., Totrov, M., Nadas, A., Kong, X. P., Zolla-Pazner, S. & Hioe, C. E., Aug 18 2016, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

5 Scopus citations

E2 multimeric scaffold for vaccine formulation: Immune response by intranasal delivery and transcriptome profile of E2-pulsed dendritic cells

Trovato, M., Maurano, F., D'Apice, L., Costa, V., Sartorius, R., Cuccaro, F., McBurney, S. P., Krebs, S. J., Prisco, A., Ciccodicola, A., Rossi, M., Haigwood, N. & De Berardinis, P., Jul 16 2016, In : BMC Microbiology. 16, 1, 152.

Research output: Contribution to journalArticle

3 Scopus citations

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

Hessell, A., Jaworski, J. P., Epson, E., Matsuda, K., Pandey, S., Kahl, C., Reed, J., Sutton, W. F., Hammond, K. B., Cheever, T. A., Barnette, P. T., Legasse, A. W., Planer, S., Stanton, J., Pegu, A., Chen, X., Wang, K., Siess, D., Burke, D., Park, B. & 7 others, Axthelm, M., Lewis, A., Hirsch, V. M., Graham, B. S., Mascola, J. R., Sacha, J. & Haigwood, N., Apr 1 2016, In : Nature Medicine. 22, 4, p. 362-368 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Induction of neutralizing antibodies in rhesus macaques using V3 mimotope peptides

Hessell, A., McBurney, S., Pandey, S., Sutton, W., Liu, L., Li, L., Totrov, M., Zolla-Pazner, S., Haigwood, N. & Gorny, M. K., May 23 2016, In : Vaccine. 34, 24, p. 2713-2721 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Animal models in HIV-1 protection and therapy

Hessell, A. J. & Haigwood, N. L., May 27 2015, In : Current Opinion in HIV and AIDS. 10, 3, p. 170-176 7 p.

Research output: Contribution to journalReview article

31 Scopus citations

Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates

McBurney, S. P., Sunshine, J. E., Gabriel, S., Huynh, J. P., Sutton, W. F., Fuller, D. H., Haigwood, N. & Messer, W., Nov 28 2015, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

10 Scopus citations

Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Specific Human Monoclonal Antibodies

Kobie, J. J., Zheng, B., Piepenbrink, M. S., Hessell, A. J., Haigwood, N. L., Keefer, M. C. & Sanz, I., Apr 1 2015, In : Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 34, 2, p. 65-72 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

HIV: Tied down by its own receptor

Haigwood, N. L., Mar 5 2015, In : Nature. 519, 7541, p. 36-37 2 p.

Research output: Contribution to journalShort survey

2014

Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1

Sather, D. N., Carbonetti, S., Malherbe, D. C., Pissani, F., Stuart, A. B., Hessell, A. J., Gray, M. D., Mikell, I., Kalams, S. A., Haigwood, N. L. & Stamatatos, L., Jan 1 2014, In : Journal of virology. 88, 22, p. 12968-12981 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Envelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits

Malherbe, D. C., Pissani, F., Noah Sather, D., Guo, B., Pandey, S., Sutton, W. F., Stuart, A. B., Robins, H., Park, B., Krebs, S. J., Schuman, J. T., Kalams, S., Hessell, A. J. & Haigwood, N. L., Jan 1 2014, In : Journal of virology. 88, 22, p. 12949-12967 19 p.

Research output: Contribution to journalArticle

22 Scopus citations

Improvement of antibody responses by HIV envelope DNA and protein co-immunization

Pissani, F., Malherbe, D. C., Schuman, J. T., Robins, H., Park, B. S., Krebs, S. J., Barnett, S. W. & Haigwood, N. L., Jan 16 2014, In : Vaccine. 32, 4, p. 507-513 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Multimeric scaffolds displaying the HIV-1 Envelope mper induce mper-specific antibodies and cross-neutralizing antibodies when Co-Immunized with gp160 DNA

Krebs, S. J., McBurney, S. P., Kovarik, D. N., Waddell, C. D., Jaworski, J. P., Sutton, W. F., Gomes, M. M., Trovato, M., Waagmeester, G., Barnett, S. J., DeBerardinis, P. & Haigwood, N. L., Dec 2014, In : PloS one. 9, 12, e0113463.

Research output: Contribution to journalArticle

22 Scopus citations

Vaccine delivery to the oral cavity using coated microneedles induces systemic and mucosal immunity

Ma, Y., Tao, W., Krebs, S. J., Sutton, W. F., Haigwood, N. L. & Gill, H. S., Mar 13 2014, In : Pharmaceutical Research. 31, 9, p. 2393-2403 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2013

HIV-1 Envelope Glycoprotein Resistance to Monoclonal Antibody 2G12 Is Subject-Specific and Context-Dependent in Macaques and Humans

Malherbe, D. C., Sanders, R. W., van Gils, M. J., Park, B., Gomes, M. M., Schuitemaker, H., Barnett, S. & Haigwood, N. L., Sep 9 2013, In : PloS one. 8, 9, e75277.

Research output: Contribution to journalArticle

3 Scopus citations

Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques

Jaworski, J. P., Kobie, J., Brower, Z., Malherbe, D. C., Landucci, G., Sutton, W. F., Guo, B., Reed, J. S., Leon, E. J., Engelmann, F., Zheng, B., Legasse, A., Park, B., Dickerson, M., Lewis, A. D., Colgin, L. M. A., Axthelm, M., Messaoudi, I., Sacha, J. B., Burton, D. R. & 3 others, Forthal, D. N., Hessell, A. J. & Haigwood, N. L., Oct 28 2013, In : Journal of virology. 87, 19, p. 10447-10459 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

SIV infection of rhesus macaques of Chinese origin: A suitable model for HIV infection in humans

Zhou, Y., Bao, R., Haigwood, N. L., Persidsky, Y. & Ho, W. Z., Aug 15 2013, In : Retrovirology. 10, 1, 89.

Research output: Contribution to journalReview article

32 Scopus citations
2012

Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8 + T cells

Jaworski, J. P., Krebs, S. J., Trovato, M., Kovarik, D. N., Brower, Z., Sutton, W. F., Waagmeester, G., Sartorius, R., D'Apice, L., Caivano, A., Doria-Rose, N. A., Malherbe, D., Montefiori, D. C., Barnett, S., de Berardinis, P. & Haigwood, N. L., Feb 16 2012, In : PloS one. 7, 2, e31464.

Research output: Contribution to journalArticle

23 Scopus citations

Lessons in nonhuman primate models for AIDS vaccine research: From minefields to milestones

Lifson, J. D. & Haigwood, N. L., Jun 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 6, a007310.

Research output: Contribution to journalArticle

38 Scopus citations

Motif-optimized subtype A HIV envelope-based DNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially

Pissani, F., Malherbe, D. C., Robins, H., DeFilippis, V. R., Park, B., Sellhorn, G., Stamatatos, L., Overbaugh, J. & Haigwood, N. L., Aug 10 2012, In : Vaccine. 30, 37, p. 5519-5526 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Neutralizing antibodies and control of HIV: Moves and countermoves

Hessell, A. J. & Haigwood, N. L., Mar 1 2012, In : Current HIV/AIDS Reports. 9, 1, p. 64-72 9 p.

Research output: Contribution to journalReview article

18 Scopus citations
2011

Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in Vivo development of neutralizing antibodies

Malherbe, D. C., Doria-Rose, N. A., Misher, L., Beckett, T., Puryear, W. B., Schuman, J. T., Kraft, Z., O'Malley, J., Mori, M., Srivastava, I., Barnett, S., Stamatatos, L. & Haigwood, N. L., Jun 1 2011, In : Journal of virology. 85, 11, p. 5262-5274 13 p.

Research output: Contribution to journalArticle

61 Scopus citations
2010

HIV-1 Gag p17 presented as virus-like particles on the E2 scaffold from Geobacillus stearothermophilus induces sustained humoral and cellular immune responses in the absence of IFNγ production by CD4+ T cells

Caivano, A., Doria-Rose, N. A., Buelow, B., Sartorius, R., Trovato, M., D'Apice, L., Domingo, G. J., Sutton, W. F., Haigwood, N. L. & De Berardinis, P., Nov 25 2010, In : Virology. 407, 2, p. 296-305 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Introduction

Haigwood, N. L., Yamamoto, N. & Iwamoto, A., May 26 2010, In : Vaccine. 28, SUPPL. 2, p. B1

Research output: Contribution to journalEditorial

Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques

Ng, C. T., Jaworski, J. P., Jayaraman, P., Sutton, W. F., Delio, P., Kuller, L., Anderson, D., Landucci, G., Richardson, B. A., Burton, D. R., Forthal, D. N. & Haigwood, N. L., Oct 1 2010, In : Nature medicine. 16, 10, p. 1117-1119 3 p.

Research output: Contribution to journalArticle

105 Scopus citations
2009

Blocking and tackling HIV

Haigwood, N. L. & Hirsch, V. M., Aug 1 2009, In : Nature medicine. 15, 8, p. 841-842 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

Continuous viral escape and selection by autologous neutralizing antibodies in drug-naïve human immunodeficiency virus controllers

Mahalanabis, M., Jayaraman, P., Miura, T., Pereyra, F., Chester, E. M., Richardson, B., Walker, B. & Haigwood, N. L., Jan 1 2009, In : Journal of virology. 83, 2, p. 662-672 11 p.

Research output: Contribution to journalArticle

85 Scopus citations

High specific infectivity of plasma virus from the pre-ramp-up and ramp-up stages of acute simian immunodeficiency virus infection

Ma, Z. M., Stone, M., Piatak, M., Schweighardt, B., Haigwood, N. L., Montefiori, D., Lifson, J. D., Busch, M. P. & Miller, C. J., Apr 1 2009, In : Journal of virology. 83, 7, p. 3288-3297 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Immune responses to measles and tetanus vaccines among Kenyan human immunodeficiency virus type 1 (HIV-1)-infected children pre- and post-highly active antiretroviral therapy and revaccination

Farquhar, C., Wamalwa, D., Selig, S., John-Stewart, G., Mabuka, J., Majiwa, M., Sutton, W., Haigwood, N., Wariua, G. & Lohman-Payne, B., Apr 2009, In : Pediatric Infectious Disease Journal. 28, 4, p. 295-299 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

P05-10. Sequential immunization with a subtype B HIV-1 envelope quasispecies elicits broader neutralization than vaccination with a single envelope clone

Malherbe, D. C., Doria-Rose, N., Misher, L., Beckett, T., Blay-Puryear, W., Barnett, S., Srivastava, I., Richardson, B., Stamatatos, L. & Haigwood, N. L., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, p. P86 1742.

Research output: Contribution to journalComment/debate

Open Access
21 Scopus citations

Update on animal models for HIV research

Haigwood, N. L., Aug 1 2009, In : European Journal of Immunology. 39, 8, p. 1994-1999 6 p.

Research output: Contribution to journalReview article

21 Scopus citations