• 2712 Citations
  • 26 h-Index
19982020
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Research Output 1998 2019

  • 2712 Citations
  • 26 h-Index
  • 55 Article
  • 2 Comment/debate
  • 1 Review article
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Article
2018
1 Citation (Scopus)

GFZF, a glutathione S-transferase protein implicated in cell cycle regulation and hybrid inviability, is a transcriptional coactivator

Baumann, D. G., Dai, M., Lu, H. & Gilmour, D. S., Feb 1 2018, In : Molecular and Cellular Biology. 38, 4, e00476-17.

Research output: Contribution to journalArticle

Glutathione Transferase
Cell Cycle
Biological Phenomena
Mitogen-Activated Protein Kinases
DNA Damage
2 Citations (Scopus)

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Geng, H., Xue, C., Mendonca, J., Sun, X-X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. T., Dai, M., Kachhap, S. K. & Qian, Z. D., Dec 1 2018, In : Nature Communications. 9, 1, 4972.

Research output: Contribution to journalArticle

hypoxia
Androgen Receptors
Androgens
therapy
switches
5 Citations (Scopus)

microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1

Chen, X., Zhao, M., Huang, J., Li, Y., Wang, S., Harrington, C. C., Qian, Z. D., Sun, X-X. & Dai, M., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

MicroRNAs
Cell Movement
Zonula Occludens-1 Protein
Cells
Tissue
6 Citations (Scopus)

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals

Su, Y., Pelz, C., Huang, T., Torkenczy, K., Wang, X., Cherry, A., Daniel, C. J., Liang, J., Nan, X., Dai, M., Adey, A., Impey, S. & Sears, R., Nov 1 2018, In : Genes & development. 32, 21-22, p. 1398-1419 22 p.

Research output: Contribution to journalArticle

Nuclear Pore
Post Translational Protein Processing
Chromatin
Histone Code
Gene Expression
3 Citations (Scopus)

The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase

DeVine, T., Sears, R. & Dai, M., Jan 15 2018, In : Biochemical and Biophysical Research Communications. 495, 3, p. 2363-2368 6 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Histones
Genes
Deregulation
Cell proliferation
2017
9 Citations (Scopus)

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

Chen, Y., Wang, Y. G., Li, Y., Sun, X-X. & Dai, M., 2017, In : Oncotarget. 8, 7, p. 11053-11062 10 p.

Research output: Contribution to journalArticle

Mitochondria
Apoptosis
Ubiquitin-Conjugating Enzymes
Ubiquitination
Cytosol
4 Citations (Scopus)

RHEB1 insufficiency in aged male mice is associated with stress-induced seizures

Tian, Q., Gromov, P., Clement, J. H., Wang, Y., Riemann, M., Weih, F., Sun, X-X., Dai, M. & Fedorov, L., Sep 10 2017, (Accepted/In press) In : GeroScience. p. 1-14 14 p.

Research output: Contribution to journalArticle

Sirolimus
Seizures
Brain
TOR Serine-Threonine Kinases
Gene Knockout Techniques
5 Citations (Scopus)

ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival

Van Hook, K., Wang, Z., Chen, D., Nold, C., Zhu, Z., Anur, P., Lee, H. J., Yu, Z., Sheppard, B., Dai, M., Sears, R., Spellman, P. & Lopez, C., Jan 22 2017, In : Biochemical and Biophysical Research Communications. 482, 4, p. 1271-1277 7 p.

Research output: Contribution to journalArticle

p53 Genes
DNA Damage
Tumors
Protein Isoforms
Apoptosis
2016
16 Citations (Scopus)

Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop

He, X., Li, Y., Dai, M. & Sun, X-X., Mar 29 2016, In : Oncotarget. 7, 13, p. 16217-16226 10 p.

Research output: Contribution to journalArticle

Ribosomal Proteins
Cell Proliferation
Ubiquitination
Growth
Cell Cycle Checkpoints
2015
10 Citations (Scopus)

Deubiquitinating c-Myc: USP36 steps up in the nucleolus

Sun, X-X., Sears, R. & Dai, M., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3786-3793 8 p.

Research output: Contribution to journalArticle

Ubiquitination
Ligases
Ubiquitin
Transcriptional Activation
Phosphorylation
16 Citations (Scopus)

Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein

Earley, L. F., Kawano, Y., Adachi, K., Sun, X-X., Dai, M. & Nakai, H., 2015, In : Journal of Virology. 89, 6, p. 3038-3048 11 p.

Research output: Contribution to journalArticle

Dependovirus
Nuclear Localization Signals
serotypes
capsid
Capsid
15 Citations (Scopus)

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

Li, Y., Challagundla, K. B., Sun, X-X., Zhang, Q. & Dai, M., 2015, In : Oncotarget. 6, 2, p. 1101-1114 14 p.

Research output: Contribution to journalArticle

MicroRNAs
Messenger RNA
DNA Damage
Cell Proliferation
Proto-Oncogene Proteins c-myc
50 Citations (Scopus)

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc

Sun, X-X., He, X., Yin, L., Komada, M., Sears, R. & Dai, M., Mar 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 12, p. 3734-3739 6 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Ubiquitin
F-Box Proteins
Proto-Oncogene Proteins c-myc
myc Genes
2014
6 Citations (Scopus)

Growth inhibitory effects of large subunit ribosomal proteins in melanoma

Kardos, G. R., Dai, M. & Robertson, G. P., 2014, In : Pigment Cell and Melanoma Research. 27, 5, p. 801-812 12 p.

Research output: Contribution to journalArticle

Ribosomal Proteins
Melanoma
Cell Proliferation
Protein Biosynthesis
Growth
26 Citations (Scopus)
Tumors
Carrier Proteins
Chemical activation
Enzymes
Neoplasms
6 Citations (Scopus)

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF

Lo, D., Zhang, Y., Dai, M., Sun, X-X., Zeng, S. X. & Lu, H., Apr 28 2014, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Reading Frames
Ligases
Ubiquitin
Neoplasms
Growth
2013
32 Citations (Scopus)

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy

Devine, T. & Dai, M., 2013, In : Current Pharmaceutical Design. 19, 18, p. 3248-3262 15 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Neoplasms
Therapeutics
Ubiquitination
2012
51 Citations (Scopus)

HIF1α protein stability is increased by acetylation at lysine 709

Geng, H., Liu, Q., Xue, C., David, L., Beer, T. T., Thomas, G., Dai, M. & Qian, Z. D., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35496-35505 10 p.

Research output: Contribution to journalArticle

Acetylation
Protein Stability
Lysine
Proteins
Cells
20 Citations (Scopus)

Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF

Dai, M., Challagundla, K. B., Sun, X-X., Palam, L. R., Zeng, S. X., Wek, R. C. & Lu, H., May 18 2012, In : Journal of Biological Chemistry. 287, 21, p. 17120-17129 10 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Tumors
Activity Cycles
Tumor Suppressor Protein p53
Ribosomes
85 Citations (Scopus)

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

Sun, X-X., Challagundla, K. B. & Dai, M., Feb 1 2012, In : EMBO Journal. 31, 3, p. 576-592 17 p.

Research output: Contribution to journalArticle

Ubiquitin
Ubiquitination
Enzymes
Ubiquitin-Specific Proteases
Protein Stability
16 Citations (Scopus)

Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion

Lo, D., Dai, M., Sun, X-X., Zeng, S. X. & Lu, H., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10013-10020 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
Guanosine Triphosphate
Fibroblasts
Mycophenolic Acid
2011
55 Citations (Scopus)

Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress

Sun, X-X., DeVine, T., Challagundla, K. B. & Dai, M., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 22730-22741 12 p.

Research output: Contribution to journalArticle

Ribosomal Proteins
Chemical activation
Dactinomycin
Ubiquitin C
Proteins
61 Citations (Scopus)

Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress

Challagundla, K. B., Sun, X-X., Zhang, X., DeVine, T., Zhang, Q., Sears, R. & Dai, M., Oct 2011, In : Molecular and Cellular Biology. 31, 19, p. 4007-4021 15 p.

Research output: Contribution to journalArticle

MicroRNAs
Messenger RNA
Dactinomycin
ribosomal protein L11
RNA Stability
2010
55 Citations (Scopus)

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation

Sun, X-X., Wang, Y. G., Xirodimas, D. P. & Dai, M., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25812-25821 10 p.

Research output: Contribution to journalArticle

L 30
Ribosomal Proteins
Chemical activation
ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate
Ribosome Subunits
39 Citations (Scopus)

Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression

Dai, M., Sun, X-X. & Lu, H., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12587-12594 8 p.

Research output: Contribution to journalArticle

Transfer RNA
rRNA Genes
RNA Polymerase III
Genes
Transcription
Transfer RNA
rRNA Genes
ribosomal protein L11
2009

Erratum: Inhibition of c-Myc activity by ribosomal protein L11 (The EMBO Journal (2009) 28 (993) DOI: 10.1038/emboj.2009.70)

Dai, M., Arnold, H., Sun, X-X., Sears, R. & Lu, H., Apr 8 2009, In : EMBO Journal. 28, 7, p. 993 1 p.

Research output: Contribution to journalArticle

ribosomal protein L11
2008
137 Citations (Scopus)

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

Dai, M., Sun, X-X. & Lu, H., Jul 2008, In : Molecular and Cellular Biology. 28, 13, p. 4365-4376 12 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Cell Proliferation
G1 Phase Cell Cycle Checkpoints
Ubiquitination
Nuclear Proteins
79 Citations (Scopus)

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

Dai, M. & Lu, H., Oct 15 2008, In : Journal of Cellular Biochemistry. 105, 3, p. 670-677 8 p.

Research output: Contribution to journalArticle

Crosstalk
Ribosomes
Proto-Oncogene Proteins c-myc
Deregulation
Ribosomal Proteins
75 Citations (Scopus)

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11

Sun, X-X., Dai, M. & Lu, H., May 2 2008, In : Journal of Biological Chemistry. 283, 18, p. 12387-12392 6 p.

Research output: Contribution to journalArticle

Mycophenolic Acid
Chemical activation
Guanine Nucleotides
Cells
G1 Phase Cell Cycle Checkpoints
2007
110 Citations (Scopus)

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction

Sun, X-X., Dai, M. & Lu, H., Mar 16 2007, In : Journal of Biological Chemistry. 282, 11, p. 8052-8059 8 p.

Research output: Contribution to journalArticle

Ribosomal Proteins
Fluorouracil
Chemical activation
Ribosomes
Feedback
33 Citations (Scopus)

Feedback regulation of c-Myc by ribosomal protein L11

Dai, M., Sears, R. & Lu, H., Nov 15 2007, In : Cell Cycle. 6, 22, p. 2735-2741 7 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-myc
Oncogene Proteins
Cell Cycle
Cells
Feedback
117 Citations (Scopus)

Inhibition of c-Myc activity by ribosomal protein L11

Dai, M., Arnold, H., Sun, X-X., Sears, R. & Lu, H., Jul 25 2007, In : EMBO Journal. 26, 14, p. 3332-3345 14 p.

Research output: Contribution to journalArticle

Cell growth
Transcription
RNA Polymerase I
Feedback
Acetylation
2006
81 Citations (Scopus)

14-3-3γ binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation

Jin, Y., Dai, M., Lu, S. Z., Xu, Y., Luo, Z., Zhao, Y. & Lu, H., Mar 22 2006, In : EMBO Journal. 25, 6, p. 1207-1218 12 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-mdm2
Chemical activation
Irradiation
Phosphorylation
Ubiquitination
53 Citations (Scopus)

Balance of yin and yang: Ubiquitylation-mediated regulation of p53 and c-Myc

Dai, M., Jin, Y., Gallegos, J. R. & Lu, H., 2006, In : Neoplasia. 8, 8, p. 630-644 15 p.

Research output: Contribution to journalArticle

Yin-Yang
Ubiquitination
Proteins
Tumor Suppressor Protein p53
Ubiquitin-Protein Ligases
138 Citations (Scopus)

Nucleophosmin is essential for ribosomal protein L5 nuclear export

Yu, Y., Maggi, L. B., Brady, S. N., Apicelli, A. J., Dai, M., Lu, H. & Weber, J. D., May 2006, In : Molecular and Cellular Biology. 26, 10, p. 3798-3809 12 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Ribosomes
Eukaryotic Large Ribosome Subunits
Centrosome
Polyribosomes
94 Citations (Scopus)

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

Dai, M., Shi, D., Jin, Y., Sun, X-X., Zhang, Y., Grossman, S. R. & Lu, H., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24304-24313 10 p.

Research output: Contribution to journalArticle

Ubiquitination
Degradation
Proteasome Endopeptidase Complex
Ligases
Ubiquitin
77 Citations (Scopus)

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

Zhang, F., Hamanaka, R. B., Bobrovnikova-Marjon, E., Gordan, J. D., Dai, M., Lu, H., Simon, M. C. & Diehl, J. A., Oct 6 2006, In : Journal of Biological Chemistry. 281, 40, p. 30036-30045 10 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Cell Cycle Checkpoints
Phosphotransferases
Endoplasmic Reticulum
Cells
2004
Ubiquitination
Degradation
ribosomal protein L5
1 Citation (Scopus)

Erratum: SSRP1 functions as a co-activator of the transcriptional activator p63 (EMBO Journal (2004) 23 (1679) doi:10.1038/sj.emboj.7600207)

Zeng, S. X., Dai, M., Keller, D. M. & Lu, H., Apr 7 2004, In : EMBO Journal. 23, 7, p. 1679 1 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein

Dai, M., Sun, X-X., Qin, J., Smolik, S. M. & Lu, H., Nov 1 2004, In : Gene. 342, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Zinc Fingers
Glutathione Transferase
Drosophila melanogaster
Proteins
Diptera
359 Citations (Scopus)

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

Dai, M. & Lu, H., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44475-44482 8 p.

Research output: Contribution to journalArticle

Ubiquitination
Dactinomycin
Degradation
Ribosomal Proteins
Oncogene Proteins
356 Citations (Scopus)

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

Dai, M., Zeng, S. X., Jin, Y., Sun, X-X., David, L. & Lu, H., Sep 2004, In : Molecular and Cellular Biology. 24, 17, p. 7654-7668 15 p.

Research output: Contribution to journalArticle

Ribosomal Proteins
Polyribosomes
Ubiquitination
Dactinomycin
Ribosomes
2003
165 Citations (Scopus)

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

Jin, Y., Lee, H., Zeng, S. X., Dai, M. & Lu, H., Dec 1 2003, In : EMBO Journal. 22, 23, p. 6365-6377 13 p.

Research output: Contribution to journalArticle

Ubiquitination
Ubiquitin
Degradation
Proteasome Inhibitors
Cell growth
2002
65 Citations (Scopus)

MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation

Jin, Y., Zeng, S. X., Dai, M., Yang, X. J. & Lu, H., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 30838-30843 6 p.

Research output: Contribution to journalArticle

Acetylation
Chemical activation
p300-CBP-associated factor
Immunoprecipitation
Transcriptional Activation
64 Citations (Scopus)

SSRP1 functions as a co-activator of the transcriptional activator p63

Zeng, S. X., Dai, M., Keller, D. M. & Lu, H., Oct 15 2002, In : EMBO Journal. 21, 20, p. 5487-5497 11 p.

Research output: Contribution to journalArticle

Luciferases
Apoptosis
HMGB1 Protein
Transcription
Fibroblasts
25 Citations (Scopus)

The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific

Dai, M., Chevallier, N., Stone, S., Heinrich, M., McConnell, M., Reuter, T., Broxmeyer, H. E., Licht, J. D., Lu, L. & Hoatlin, M., Jul 19 2002, In : Journal of Biological Chemistry. 277, 29, p. 26327-26334 8 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Zinc Fingers
Zinc
Cell Cycle
Cells
2000
28 Citations (Scopus)

An expansion phase precedes terminal erythroid differentiation of hematopoietic progenitor cells from cord blood in vitro and is associated with up-regulation of cyclin E and cyclin-dependent kinase 2

Dai, M., Mantel, C. R., Xia, Z. B., Broxmeyer, H. E. & Lu, L., Dec 1 2000, In : Blood. 96, 12, p. 3985-3987 3 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
Cyclin E
Hematopoietic Stem Cells
Fetal Blood
Cyclin D3
3 Citations (Scopus)

Co-transduction of cDNAs for c-kit and steel factor into single CD34+ cord blood cells further enhances the growth of erythroid and multipotential progenitors

Lu, L., Dai, M., Ge, Y., Wang, L. S., Braun, S. E., Wait, C. L., Griffith, D. J., Heinrich, M. & Broxmeyer, H. E., 2000, In : Journal of Hematotherapy and Stem Cell Research. 9, 6, p. 813-825 13 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Fetal Blood
Blood Cells
Complementary DNA
Growth
14 Citations (Scopus)

Differentially expressed genes during in vitro differentiation of murine embryonic stem cells transduced with a human erythropoietin receptor cDNA

Xia, Z. B., Dai, M., Magoulas, C., Broxmeyer, H. E. & Lu, L., 2000, In : Journal of Hematotherapy and Stem Cell Research. 9, 5, p. 651-658 8 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Embryonic Stem Cells
Complementary DNA
Erythropoietin
Genes