• 2849 Citations
  • 26 h-Index
19982020

Research output per year

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Research Output

  • 2849 Citations
  • 26 h-Index
  • 49 Article
  • 6 Comment/debate
  • 4 Review article
2020

Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity

Risom, T., Wang, X., Liang, J., Zhang, X., Pelz, C., Campbell, L. G., Eng, J., Chin, K., Farrington, C., Narla, G., Langer, E. M., Sun, X. X., Su, Y., Daniel, C. J., Dai, M. S., Löhr, C. V. & Sears, R. C., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 231-246 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Erratum to: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy (Nature Communications, (2018), 9, 1, (4972), 10.1038/s41467-018-07411-7)

Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. K. & Qian, D. Z., Dec 1 2019, In : Nature communications. 10, 1, 164.

Research output: Contribution to journalComment/debate

Writing and erasing MYC ubiquitination and SUMOylation

Chen, Y., Sun, X. X., Sears, R. C. & Dai, M. S., Dec 2019, In : Genes and Diseases. 6, 4, p. 359-371 13 p.

Research output: Contribution to journalReview article

Open Access
2018

GFZF, a glutathione S-transferase protein implicated in cell cycle regulation and hybrid inviability, is a transcriptional coactivator

Baumann, D. G., Dai, M., Lu, H. & Gilmour, D. S., Feb 1 2018, In : Molecular and Cellular Biology. 38, 4, e00476-17.

Research output: Contribution to journalArticle

2 Scopus citations

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. K. & Qian, D. Z., Dec 1 2018, In : Nature communications. 9, 1, 4972.

Research output: Contribution to journalArticle

4 Scopus citations

microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1

Chen, X., Zhao, M., Huang, J., Li, Y., Wang, S., Harrington, C. C., Qian, Z. D., Sun, X-X. & Dai, M., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

15 Scopus citations

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals

Su, Y., Pelz, C., Huang, T., Torkenczy, K., Wang, X., Cherry, A., Daniel, C. J., Liang, J., Nan, X., Dai, M., Adey, A., Impey, S. & Sears, R., Nov 1 2018, In : Genes & development. 32, 21-22, p. 1398-1419 22 p.

Research output: Contribution to journalArticle

13 Scopus citations

The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase

DeVine, T., Sears, R. & Dai, M., Jan 15 2018, In : Biochemical and Biophysical Research Communications. 495, 3, p. 2363-2368 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

Chen, Y., Wang, Y. G., Li, Y., Sun, X. X. & Dai, M. S., Jan 1 2017, In : Oncotarget. 8, 7, p. 11053-11062 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

p73 to the rescue: Role of RPL26

Sun, X-X. & Dai, M., 2017, In : Oncotarget. 8, 4, p. 5641-5642 2 p.

Research output: Contribution to journalComment/debate

RHEB1 insufficiency in aged male mice is associated with stress-induced seizures

Tian, Q., Gromov, P., Clement, J. H., Wang, Y., Riemann, M., Weih, F., Sun, X-X., Dai, M. & Fedorov, L., Sep 10 2017, (Accepted/In press) In : GeroScience. p. 1-14 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival

Van Hook, K., Wang, Z., Chen, D., Nold, C., Zhu, Z., Anur, P., Lee, H. J., Yu, Z., Sheppard, B., Dai, M. S., Sears, R., Spellman, P. & Lopez, C. D., Jan 22 2017, In : Biochemical and Biophysical Research Communications. 482, 4, p. 1271-1277 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop

He, X., Li, Y., Dai, M. S. & Sun, X. X., Mar 29 2016, In : Oncotarget. 7, 13, p. 16217-16226 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Deubiquitinating c-Myc: USP36 steps up in the nucleolus

Sun, X-X., Sears, R. & Dai, M., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3786-3793 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein

Earley, L. F., Kawano, Y., Adachi, K., Sun, X. X., Dai, M. S. & Nakai, H., Jan 1 2015, In : Journal of virology. 89, 6, p. 3038-3048 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

Li, Y., Challagundla, K. B., Sun, X. X., Zhang, Q. & Dai, M. S., Jan 1 2015, In : Oncotarget. 6, 2, p. 1101-1114 14 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF

Lo, D., Zhang, Y., Dai, M. S., Sun, X. X., Zeng, S. X. & Lu, H., Mar 26 2015, In : Oncogene. 34, 13, p. 1688-1697 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc

Sun, X. X., He, X., Yin, L., Komada, M., Sears, R. C. & Dai, M. S., Mar 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 12, p. 3734-3739 6 p.

Research output: Contribution to journalArticle

57 Scopus citations
2014

Growth inhibitory effects of large subunit ribosomal proteins in melanoma

Kardos, G. R., Dai, M. S. & Robertson, G. P., Jan 1 2014, In : Pigment Cell and Melanoma Research. 27, 5, p. 801-812 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
26 Scopus citations
2013

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy

Devine, T. & Dai, M. S., Jun 17 2013, In : Current Pharmaceutical Design. 19, 18, p. 3248-3262 15 p.

Research output: Contribution to journalArticle

32 Scopus citations
2012

HIF1α protein stability is increased by acetylation at lysine 709

Geng, H., Liu, Q., Xue, C., David, L. L., Beer, T. M., Thomas, G. V., Dai, M. S. & Qian, D. Z., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35496-35505 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF

Dai, M. S., Challagundla, K. B., Sun, X. X., Palam, L. R., Zeng, S. X., Wek, R. C. & Lu, H., May 18 2012, In : Journal of Biological Chemistry. 287, 21, p. 17120-17129 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

Sun, X. X., Challagundla, K. B. & Dai, M. S., Feb 1 2012, In : EMBO Journal. 31, 3, p. 576-592 17 p.

Research output: Contribution to journalArticle

96 Scopus citations

Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion

Lo, D., Dai, M. S., Sun, X. X., Zeng, S. X. & Lu, H., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10013-10020 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress

Sun, X. X., DeVine, T., Challagundla, K. B. & Dai, M. S., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 22730-22741 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress

Challagundla, K. B., Sun, X. X., Zhang, X., DeVine, T., Zhang, Q., Sears, R. C. & Dai, M. S., Oct 1 2011, In : Molecular and Cellular Biology. 31, 19, p. 4007-4021 15 p.

Research output: Contribution to journalArticle

65 Scopus citations
2010

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation

Sun, X. X., Wang, Y. G., Xirodimas, D. P. & Dai, M. S., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25812-25821 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression

Dai, M. S., Sun, X. X. & Lu, H., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12587-12594 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

Erratum: Inhibition of c-Myc activity by ribosomal protein L11 (The EMBO Journal (2009) 28 (993) DOI: 10.1038/emboj.2009.70)

Dai, M. S., Arnold, H., Sun, X. X., Sears, R. & Lu, H., Apr 8 2009, In : EMBO Journal. 28, 7, 1 p.

Research output: Contribution to journalComment/debate

2008

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

Dai, M. S., Sun, X. X. & Lu, H., Jul 1 2008, In : Molecular and cellular biology. 28, 13, p. 4365-4376 12 p.

Research output: Contribution to journalArticle

139 Scopus citations

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

Dai, M. S. & Lu, H., Oct 15 2008, In : Journal of cellular biochemistry. 105, 3, p. 670-677 8 p.

Research output: Contribution to journalReview article

79 Scopus citations

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11

Sun, X. X., Dai, M. S. & Lu, H., May 2 2008, In : Journal of Biological Chemistry. 283, 18, p. 12387-12392 6 p.

Research output: Contribution to journalArticle

78 Scopus citations
2007

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction

Sun, X. X., Dai, M. S. & Lu, H., Mar 16 2007, In : Journal of Biological Chemistry. 282, 11, p. 8052-8059 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

Feedback regulation of c-Myc by ribosomal protein L11

Dai, M. S., Sears, R. & Lu, H., Nov 15 2007, In : Cell Cycle. 6, 22, p. 2735-2741 7 p.

Research output: Contribution to journalReview article

Open Access
33 Scopus citations

Inhibition of c-Myc activity by ribosomal protein L11

Dai, M. S., Arnold, H., Sun, X. X., Sears, R. & Lu, H., Jul 25 2007, In : EMBO Journal. 26, 14, p. 3332-3345 14 p.

Research output: Contribution to journalArticle

123 Scopus citations
2006

14-3-3γ binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation

Jin, Y., Dai, M. S., Lu, S. Z., Xu, Y., Luo, Z., Zhao, Y. & Lu, H., Mar 22 2006, In : EMBO Journal. 25, 6, p. 1207-1218 12 p.

Research output: Contribution to journalArticle

83 Scopus citations

Balance of yin and yang: Ubiquitylation-mediated regulation of p53 and c-Myc

Dai, M. S., Jin, Y., Gallegos, J. R. & Lu, H., Jan 1 2006, In : Neoplasia. 8, 8, p. 630-644 15 p.

Research output: Contribution to journalReview article

55 Scopus citations

Nucleophosmin is essential for ribosomal protein L5 nuclear export

Yu, Y., Maggi, L. B., Brady, S. N., Apicelli, A. J., Dai, M. S., Lu, H. & Weber, J. D., May 1 2006, In : Molecular and cellular biology. 26, 10, p. 3798-3809 12 p.

Research output: Contribution to journalArticle

139 Scopus citations

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

Dai, M. S., Shi, D., Jin, Y., Sun, X. X., Zhang, Y., Grossman, S. R. & Lu, H., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24304-24313 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

Zhang, F., Hamanaka, R. B., Bobrovnikova-Marjon, E., Gordan, J. D., Dai, M. S., Lu, H., Simon, M. C. & Diehl, J. A., Oct 6 2006, In : Journal of Biological Chemistry. 281, 40, p. 30036-30045 10 p.

Research output: Contribution to journalArticle

79 Scopus citations
2004

Erratum: SSRP1 functions as a co-activator of the transcriptional activator p63 (EMBO Journal (2004) 23 (1679) doi:10.1038/sj.emboj.7600207)

Zeng, S. X., Dai, M. S., Keller, D. M. & Lu, H., Apr 7 2004, In : EMBO Journal. 23, 7, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein

Dai, M. S., Sun, X. X., Qin, J., Smolik, S. M. & Lu, H., Nov 1 2004, In : Gene. 342, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

Dai, M. S. & Lu, H., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44475-44482 8 p.

Research output: Contribution to journalArticle

376 Scopus citations

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

Dai, M. S., Zeng, S. X., Jin, Y., Sun, X. X., David, L. & Lu, H., Sep 1 2004, In : Molecular and cellular biology. 24, 17, p. 7654-7668 15 p.

Research output: Contribution to journalArticle

366 Scopus citations
2003

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

Jin, Y., Lee, H., Zeng, S. X., Dai, M. S. & Lu, H., Dec 1 2003, In : EMBO Journal. 22, 23, p. 6365-6377 13 p.

Research output: Contribution to journalArticle

169 Scopus citations
2002

MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation

Jin, Y., Zeng, S. X., Dai, M. S., Yang, X. J. & Lu, H., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 30838-30843 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

SSRP1 functions as a co-activator of the transcriptional activator p63

Zeng, S. X., Dai, M. S., Keller, D. M. & Lu, H., Oct 15 2002, In : EMBO Journal. 21, 20, p. 5487-5497 11 p.

Research output: Contribution to journalArticle

65 Scopus citations