Michael Klein

Professor

  • 15157 Citations
  • 62 h-Index
1974 …2020

Research output per year

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Research Output

  • 15157 Citations
  • 62 h-Index
  • 137 Article
  • 10 Letter
  • 9 Review article
  • 2 Comment/debate
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Article
2019

Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Grassmann, F., Harsch, S., Brandl, C., Kiel, C., Nürnberg, P., Toliat, M. R., Fleckenstein, M., Pfau, M., Schmitz-Valckenberg, S., Holz, F. G., Chew, E. Y., Swaroop, A., Ratnapriya, R., Klein, M. L., Mulyukov, Z., Zamiri, P. & Weber, B. H. F., Aug 2019, In : JAMA ophthalmology. 137, 8, p. 867-876 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Incidence of Macular Atrophy after Untreated Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study Report 40

Age-Related Eye Diseases Study Research Group, Jan 1 2019, (Accepted/In press) In : Ophthalmology.

Research output: Contribution to journalArticle

Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17

Age-Related Eye Disease Study 2 Research Group, Feb 2019, In : Ophthalmology. 126, 2, p. 261-273 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Precursors and Development of Geographic Atrophy with Autofluorescence Imaging: Age-Related Eye Disease Study 2 Report Number 18

Age-Related Eye Disease Study 2 Research Group, Sep 1 2019, In : Ophthalmology Retina. 3, 9, p. 724-733 10 p.

Research output: Contribution to journalArticle

2018

Genome-wide analysis of disease progression in age-related macular degeneration

AREDS2 Research Group, Mar 1 2018, In : Human molecular genetics. 27, 5, p. 929-940 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16

AREDS2 Research Group, Dec 2018, In : Ophthalmology. 125, 12, p. 1913-1928 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
2017

Bivariate analysis of age-related macular degeneration progression using genetic risk scores

Ding, Y., Liu, Y., Yan, Q., Fritsche, L. G., Cook, R. J., Clemons, T., Ratnapriya, R., Klein, M. L., Abecasis, G. R., Swaroop, A., Chew, E. Y., Weeks, D. E. & Chen, W., May 2017, In : Genetics. 206, 1, p. 119-133 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

CLINICOPATHOLOGIC CORRELATION of RETINAL ANGIOMATOUS PROLIFERATION TREATED with RANIBIZUMAB

Skalet, A., Miller, A. K., Klein, M., Lauer, A. A. & Wilson, D., Aug 1 2017, In : Retina. 37, 8, p. 1620-1624 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

International AMD Genomics Consortium (IAMDGC), Mar 27 2017, In : Genome Medicine. 9, 1, 29.

Research output: Contribution to journalArticle

27 Scopus citations

Recombinant haplotypes narrow the ARMS2/HTRA1 association signal for age-related macular degeneration

International AMD Genomics Consortium (IAMDGC), Feb 2017, In : Genetics. 205, 2, p. 919-924 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2016

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P. N., Bala, E., ELee, K., Hunter, D. J., Sardell, R. J., Mitchell, P. & 142 others, Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T. E., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H. S., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., Mackey, D. A., Constable, I. J., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Tsironi, E. E., Park, K. H., Farrer, L. A., Orlin, A., Brucker, A., Li, M., Curcio, C. A., Mohand-Sa'd, S., Sahel, J. A., Audo, I., Benchaboune, M., Cree, A. J., Rennie, C. A., Goverdhan, S. V., Grunin, M., Hagbi-Levi, S., Campochiaro, P., Katsanis, N., Holz, F. G., Blond, F., Blanché, H., Deleuze, J. F. O., Igo, R. P., Truitt, B., Peachey, N. S., Meuer, S. M., Myers, C. E., Moore, E. L., Klein, R., Hauser, M. A., Postel, E. A., Courtenay, M. D., Schwartz, S. G., Kovach, J. L., Scott, W. K., Liew, G., Tan, A. G., Gopinath, B., Merriam, J. C., Smith, R. T., Khan, J. C., Shahid, H., Moore, A. T., McGrath, J. A., Laux, R., Brantley, M. A., Agarwal, A., Ersoy, L., Caramoy, A., Langmann, T., Saksens, N. T. M., Jong, E. K., Hoyng, C. B., Cain, M. S., Richardson, A. J., Martin, T. M., Blangero, J., Weeks, D. E., Dhillon, B., Van Duijn, C. M., Doheny, K. F., Romm, J., Klaver, C. C. W., Hayward, C., Gorin, M. B., Klein, M. L., Baird, P. N., Den Hollander, A. I., Fauser, S., WYates, J. R., Allikmets, R., Wang, J. J., Schaumberg, D. A., Klein, B. E. K., Hagstrom, S. A., Chowers, I., Lotery, A. J., Léveillard, T., Zhang, K., Brilliant, M. H., Hewitt, A. W., Swaroop, A., Chew, E. Y., Pericak-Vance, M. A., DeAngelis, M., Stambolian, D., Haines, J. L., Iyengar, S. K., Weber, B. H. F., Abecasis, G. R. & Heid, I. M., Feb 1 2016, In : Nature genetics. 48, 2, p. 134-143 10 p.

Research output: Contribution to journalArticle

393 Scopus citations
2015

Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration

Grassmann, F., Fleckenstein, M., Chew, E. Y., Strunz, T., Schmitz-Valckenberg, S., Göbel, A. P., Klein, M. L., Ratnapriya, R., Swaroop, A., Holz, F. G. & Weber, B. H. F., May 11 2015, In : PloS one. 10, 5, e0126636.

Research output: Contribution to journalArticle

36 Scopus citations

Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements: To test or not to test?

Chew, E. Y., Klein, M. L., Clemons, T. E., Agrón, E. & Abecasis, G. R., Jan 1 2015, In : Ophthalmology. 122, 1, p. 212-215 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration

Meyers, K. J., Liu, Z., Millen, A. E., Iyengar, S. K., Blodi, B. A., Johnson, E., Snodderly, D. M., Klein, M. L., Gehrs, K. M., Tinker, L., Sarto, G. E., Robinson, J., Wallace, R. B. & Mares, J. A., Nov 2015, In : Ophthalmology. 122, 11, p. 2286-2294 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Willoughby, A. S., Ying, G. S., Toth, C. A., Maguire, M. G., Burns, R. E., Grunwald, J. E., Daniel, E., Jaffe, G. J., Williams, D. F., Beardsley, S., Bennett, S., Cantrill, H., Chan-Tram, C., Cheshier, H., Damato, K., Davies, J., Dev, S., Enloe, J., Follano, G., Gilbert, P. & 842 others, Johnson, J., Jones, T., Mayleben, L., Mittra, R., Moos, M., Neist, R., Oestreich, N., Quiram, P., Ramsay, R., Ryan, E., Schindeldecker, S., Snater, J., Steele, T., Selders, D., Tonsfeldt, J., Valardi, S., Fish, G. E., Aguado, H. A., Arceneaux, S., Arnwine, J., Bell, K., Bell, T., Boleman, B., Bradley, P., Callanan, D., Coors, L., Creighton, J., Crew, T., Cummings, K., Dock, C., Duignan, K., Fuller, D., Gray, K., Hendrix, B., Hesse, N., Jaramillo, D., Jost, B., Lash, S., Lonsdale, L., Mackens, M., Mutz, K., Potts, M., Sanchez, B., Snyder, W., Solley, W., Tarter, C., Wang, R., Williams, P., Perkins, S. L., Anderson, N., Arnold, A., Blais, P., Googe, J., Higdon, T. T., Hunt, C., Johnson, M., Miller, J., Moore, M., Morris, C. K., Morris, C., Oelrich, S., Oliver, K., Seitz, V., Whetstone, J., Doft, B. H., Bedel, J., Bergren, R., Borthwick, A., Conrad, P., Fec, A., Fulwylie, C., Ingram, W., Latham, S., Lester, G., Liu, J., Lobes, L., Lucko, N. M., Mechling, H., Merlotti, L., McBroom, K., Olsen, K., Puskas, D., Rath, P., Schmucker, M., Schueckler, L., Schultz, C., Shultz, H., Steinberg, D., Vyas, A., Whale, K., Yeckel, K., Orth, D. H., Arredondo, L. S., Brown, S., Ciscato, B. J., Civantos, J. M., Figliulo, C., Hasan, S., Kosinski, B., Muir, D., Nelson, K., Packo, K., Pollack, J. S., Rezaei, K., Shelton, G., Townsend-Patrick, S., Walsh, M., Richard McDonald, H., Ansari, N., Bye, A., Fu, A. D., Grout, S., Indermill, C., Johnson, R. N., Michael Jumper, J., Linares, S., Lujan, B. J., Munden, A., Persons, M., Rodriguez, R., Rose, J. M., Teske, B., Urias, Y., Young, S., Dreyer, R. F., Daniel, H., Connaughton, M., Handelman, I., Hobbs, S., Hoerner, C., Hudson, D., Kopfer, M., Lee, M., Lemley, C., Logan, J., Ma, C., Mallet, C., Milliron, A., Peters, M., Wohlsein, H., Pearlman, J. A., Andrews, M., Bartlett, M., Carlson, N., Cox, E., Equi, R., Gonzalez, M., Griffin, S., Hogue, F., Kennedy, L., Kryuchkov, L., Lopez, C., Lopez, D., Luevano, B., McKenna, E., Patel, A., Reed, B., Secor, N., Sison, I. R., Tsai, T., Varghis, N., Waller, B., Wendel, R., Yebra, R., Roth, D. B., Deinzer, J., Fine, H., Green, F., Green, S., Keyser, B., Leff, S., Leviton, A., Martir, A., Mosenthine, K., Muscle, S., Okoren, L., Parker, S., Prenner, J., Price, N., Rogers, D., Rosas, L., Schlosser, A., Studenko, L., Tantum, T., Wheatley, H., Trese, M. T., Aaberg, T., Bezaire, D., Bridges, C., Bryant, D., Capone, A., Coleman, M., Consolo, C., Cook, C., Dulong, C., Garretson, B., Grooten, T., Hammersley, J., Hassan, T., Jessick, H., Jones, N., Kinsman, C., Krumlauf, J., Lewis, S., Locke, H., Margherio, A., Markus, D., Marsh, T., Neal, S., Noffke, A., Oh, K., Pence, C., Preston, L., Raphaelian, P., Regan, V. R., Roberts, P., Ruby, A., Sarrafizadeh, R., Scherf, M., Scott, S., Sneed, S., Staples, L., Terry, B., Trese, M. T., Videtich, J., Williams, G., Zajechowski, M., Joseph, D. P., Blinder, K., Boyd, L., Buckley, S., Crow, M., Dinatale, A., Engelbrecht, N., Forke, B., Gabel, D., Grand, G., Grillion-Cerone, J., Holekamp, N., Kelly, C., Nobel, G., Pepple, K., Raeber, M., Kumar Rao, P., Ressel, T., Schremp, S., Sgorlon, M., Shears, S., Thomas, M., Timma, C., Vaughn, A., Walters, C., Weeks, R., Wehmeier, J., Wright, T., Berinstein, D. M., Ayyad, A., Barazi, M. K., Bickhart, E., Brady, T., Byank, L., Cronise, A., Denny, V., Dunn, C., Flory, M., Frantz, R., Garfinkel, R. A., Gilbert, W., Lai, M. M., Melamud, A., Newgen, J., Newton, S., Oliver, D., Osman, M., Sanders, R., Von Fricken, M., Dugel, P., Arenas, S., Balea, G., Bartoli, D., Bucci, J., Cornelius, J. A., Dickens, S., Doherty, D., Dunlap, H., Goldenberg, D., Jamal, K., Jimenez, N., Kavanagh, N., Kunimoto, D., Martin, J., Miner, J., Mobley, S., Park, D., Quinlan, E., Sipperley, J., Slagle, C., Smith, D., Yafchak, M., Yager, R., Flaxel, C. J., Bailey, S., Francis, P., Howell, C., Hwang, T., Ira, S., Klein, M., Lauer, A., Liesegang, T., Lundquist, A., Nolte, S., Nolte, S. K., Pickell, S., Pope, S., Rossi, J., Schain, M., Steinkamp, P., Toomey, M. D., Vahrenwald, D., West, K., Hubbard, B., Andelman, S., Bergstrom, C., Brower, J., Cribbs, B., Curtis, L., Dobbs, J., Dubois, L., Gaultney, J., Gibbs, D., Jordan, D., Leef, D., Martin, D. F., Myles, R., Olsen, T., Schwent, B., Srivastava, S., Waldron, R., Antoszyk, A. N., Balasubramaniam, U., Brooks, D., Brown, J., Browning, D., Clark, L., Ennis, S., Held, S., Helms, J. V., Herby, J., Karow, A., Leotaud, P., Massimino, C., McClain, D., McOwen, M., Mindel, J., Pereira, C., Pierce, R., Powers, M., Price, A., Rohrer, J., Sanders, J., Avery, R. L., Avery, K., Basefsky, J., Beckner, L., Castellarin, A., Couvillion, S., Giust, J., Giust, M., Nasir, M., Pieramici, D., Rabena, M., Risard, S., See, R., Smith, J., Wan, L., Bakri, S. J., Abu-Yaghi, N., Barkmeier, A., Berg, K., Burrington, J., Edwards, A., Goddard, S., Howard, S., Iezzi, R., Lewison, D., Link, T., McCannel, C. A., Overend, J., Pach, J., Ruszczyk, M., Shultz, R., Stephan, C., Vogen, D., Bradford, R. H., Bergman, V., Burris, R., Butt, A., Daniels, B., Dwiggins, C., Fransen, S., Guerrero, T., Haivala, D., Harris, A., Icks, S., Kingsley, R., Redden, L., Richmond, R., Ross, B., White, K., Youngberg, M., Topping, T. M., Chong, S., Ciotti, M., Cleary, T., Corey, E., Donovan, D., Frederick, A., Freese, L., Graham, M., Gud, N., Howard, T., Jones, M., Morley, M., Moses, K., Stone, J., Ty, R., Wiegand, T., Williams, L., Winder, B., Awh, C. C., Amonette, M., Arrindell, E., Beck, D., Busbee, B., Dilback, A., Downs, S., Guidry, A., Gutow, G., Hardin, J., Hines, S., Hutchins, E., Lacivita, K., Lester, A., Malott, L., McCain, M., Miracle, J., Moffat, K., Palazzotta, L., Robinson, K., Sonkin, P., Travis, A., Wallace, R. T., Winters, K. J., Wray, J., Harris, A. E., Bunnell, M., Crooks, K., Fitzgerald, R., Javid, C., Kew, C., Kill, E., Kline, P., Kreienkamp, J., Martinez, M., Ann Moore, R., Saavedra, E., Taylor, L., Walsh, M., Wilson, L., Ciulla, T. A., Coyle, E., Harrington, T., Harris, C., Hood, C., Kerr, I., Maturi, R., Moore, D., Morrow, S., Savage, J., Sink, B., Steele, T., Thukral, N., Wilburn, J., Walker, J. P., Banks, J., Ciampaglia, D., Dyshanowitz, D., Frederick, J., Tom Ghuman, A., Grodin, R., Kiesel, C., Knips, E., McCue, J., Ortiz, M., Peters, C., Raskauskas, P., Schoeman, E., Sharma, A., Wing, G., Youngblood, R., Chandra, S. R., Altaweel, M., Blodi, B., Burke, K., Dietzman, K. A., Gottlieb, J., Knutson, G., Krolnik, D., Michael Nork, T., Olson, S., Peterson, J., Reed, S., Soderling, B., Somers, G., Stevens, T., Wealti, A., Bearelly, S., Branchaud, B., Bryant, J. W., Crowell, S., Fekrat, S., Gammage, M., Harrison, C., Jones, S., McClain, N., McCuen, B., Mruthyunjaya, P., Queen, J., Sarin, N., Skalak, C., Skelly, M., Suner, I., Tomany, R., Welch, L., Park, S. S., Cassidy, A., Chandra, K., Good, I., Imson, K., Kaur, S., Metzler, H., Morse, L., Redenbo, E., Salvador, M., Telander, D., Thomas, M., Wallace, C., Barr, C. C., Battcher, A., Bottorff, M., Chasteen, M., Clark, K., Denning, D., Schoen, D., Schultz, A., Tempel, E., Wheeler, L., Whittington, G. K., Stone, T. W., Blevins, T., Buck, M., Cruz, L., Heath, W., Holcomb, D., Isernhagen, R., Kidd, T., Kitchens, J., Sears, C., Slade, E., Van Arsdall, J., Vanhoose, B., Wolfe, J., Wood, W., Zilis, J., Crooks, C., Disney, L., Liu, M., Petty, S., Sall, S., Folk, J. C., Aly, T., Brotherton, A., Critser, D., Hinz, C. J., Karakas, S., Kirschner, V., Lester, C., Montague, C., Russell, S., Stockman, H., Taylor, B., Verdick, R., Walshire, J., Thompson, J. T., Connell, B., Constantine, M., Davis, J. L., Holsapple, G., Hunter, L., Lenane, C. N., Mitchell, R., Russel, L., Sjaarda, R., Brown, D. M., Benz, M., Burns, L., Carranza, J. G., Fish, R., Goates, D., Hay, S., Jeffers, T., Kegley, E., Kubecka, D., McGilvra, S., Richter, B., Sneed, V., Stoever, C., Tellez, I., Wong, T., Kim, I., Andreoli, C., Barresi, L., Brett, S., Callahan, C., Capaccioli, K., Carli, W., Coppola, M., Emmanuel, N., Evans, C., Fagan, A., Grillo, M., Head, J., Kieser, T., Lee, E., Lord, U., Miretsky, E., Palitsch, K., Petrin, T., Reader, L., Reznichenko, S., Robertson, M., Smith, J., Vavvas, D., Wells, J., Cahill, C., Lloyd Clark, W., Henry, K., Johnson, D., Miller, P., Oliver, L., Spivey, R., Swinford, T., Taylor, M., Lambert, M., Chase, K., Fredrickson, D., Khawly, J., Lazarte, V., Lowd, D., Miller, P., Willis, A., Ferrone, P. J., Almonte, M., Arnott, R., Aviles, I., Carbon, S., Chitjian, M., Damore, K., Elliott, C., Fastenberg, D., Golub, B., Graham, K., Lavorna, A., Murphy, L., Palomo, A., Puglisi, C., Rhee, D., Romero, J., Rosenblatt, B., Salcedo, G., Schlameuss, M., Shakin, E., Sookhai, V., Kaiser, R., Affel, E., Brown, G., Centinaro, C., Fine, D., Fineman, M., Formoso, M., Garg, S., Grande, L., Herbert, C., Ho, A., Hsu, J., Jay, M., Lavetsky, L., Liebenbaum, E., Maguire, J., Monsonego, J., O'Connor, L., Pierce, L., Regillo, C., Rosario, M., Spirn, M., Vander, J., Walsh, J., Davidorf, F. H., Barnett, A., Chang, S., Christoforidis, J., Elliott, J., Justice, H., Letson, A., McKinney, K., Perry, J., Salerno, J. A., Savage, S., Shelley, S., Singerman, L. J., Coney, J., Dubois, J., Dubois, K., Greanoff, G., Himmelman, D., Ilc, M., McNamara, E., Novak, M., Pendergast, S., Rath, S., Smith-Brewer, S., Tanner, V., Weiss, D. E., Zegarra, H., Halperin, L., Aramayo, P., Dhalla, M., Fernandez, B., Fernandez, C., Lopez, J., Lopez, M., Mariano, J., Murphy, K., Sherley, C., Veksler, R., Rahhal, F., Babikian, R., Boyer, D., Hami, S., Kessinger, J., Kurokouchi, J., Mukarram, S., Pachman, S., Protacio, E., Sierra, J., Tabandeh, H., Zamboni, A., Elman, M., Belz, J., Butcher, T., Cain, T., Coffey, T., Firestone, D., Gore, N., Singletary, P., Sotirakos, P., Starr, J., Meredith, T. A., Barnhart, C. J., Cantrell, D., Esquejo-Leon, R., Houghton, O., Kaur, H., Ndure, F., Glatzer, R., Joffe, L., Schindler, R., Fine, S. L., Katz, M., Brightwell-Arnold, M., Glaser, R., Hall, J., Harkins, S., Huang, J., Khvatov, A., McWilliams, K., Peskin, E., Pistilli, M., Ryan, S., Schnader, A., Afrani-Sakyi, J., Balsley, B., Bennett, L. S., Brooks, A., Brower-Lingsch, A., Bruce, L., Busian, D., Choong, J., Cloaninger, L., DeCroos, F. C., Dubois, E., El-Dairi, M., Gach, S., Hall, K., Hawks, T., Huang, C., Heydary, C., Ho, A., Kini, S., McCall, M., Muhammad, D., Nicholson, J., Rieves, P., Shields, K., Specker, A., Stinnett, S., Subramaniam, S., Tenbrink, P., Towe, A., Welch, K., Williams, N., Winter, K., Young, E., Alexander, J., Flannagan, E., Martin, E. R., Parker, C., Sepielli, K., Shannon, T., Whearry, C., Redford, M., Kopfer, M. R., Ferris, F. L., Dupont, J., Friedman, L. M., Bressler, S. B., Demets, D. L., Friedlander, M., Johnson, M. W., Lindblad, A., Losordo, D. W. & Miller, F. G., Sep 1 2015, In : Ophthalmology. 122, 9, p. 1846-1853.e5

Research output: Contribution to journalArticle

60 Scopus citations
2014

No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38

Chew, E. Y., Klein, M. L., Clemons, T. E., Agrón, E., Ratnapriya, R., Edwards, A. O., Fritsche, L. G., Swaroop, A. & Abecasis, G. R., Nov 1 2014, In : Ophthalmology. 121, 11, p. 2173-2180 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Prevalence of anti-retinal autoantibodies in different stages of Age-related macular degeneration

Adamus, G., Chew, E. Y., Ferris, F. L. & Klein, M. L., Dec 8 2014, In : BMC ophthalmology. 14, 1, 154.

Research output: Contribution to journalArticle

16 Scopus citations

Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration

Jia, Y., Bailey, S. T., Wilson, D. J., Tan, O., Klein, M. L., Flaxel, C. J., Potsaid, B., Liu, J. J., Lu, C. D., Kraus, M. F., Fujimoto, J. G. & Huang, D., Jul 2014, In : Ophthalmology. 121, 7, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

465 Scopus citations

Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration

Ratnapriya, R., Zhan, X., Fariss, R. N., Branham, K. E., Zipprer, D., Chakarova, C. F., Sergeev, Y. V., Campos, M. M., Othman, M., Friedman, J. S., Maminishkis, A., Waseem, N. H., Brooks, M., Rajasimha, H. K., Edwards, A. O., Lotery, A., Klein, B. E., Truitt, B. J., Li, B., Schaumberg, D. A. & 47 others, Morgan, D. J., Morrison, M. A., Souied, E., Tsironi, E. E., Grassmann, F., Fishman, G. A., Silvestri, G., Scholl, H. P. N., Kim, I. K., Ramke, J., Tuo, J., Merriam, J. E., Merriam, J. C., Park, K. H., Olson, L. M., Farrer, L. A., Johnson, M. P., Peachey, N. S., Lathrop, M., Baron, R. V., Igo, R. P., Klein, R., Hagstrom, S. A., Kamatani, Y., Martin, T. M., Jiang, Y., Conley, Y., Sahel, J. A., Zack, D. J., Chan, C. C., Pericak-Vance, M. A., Jacobson, S. G., Gorin, M. B., Klein, M. L., Allikmets, R., Iyengar, S. K., Weber, B. H., Haines, J. L., Léveillard, T., Deangelis, M. M., Stambolian, D., Weeks, D. E., Bhattacharya, S. S., Chew, E. Y., Heckenlively, J. R., Abecasis, G. R. & Swaroop, A., Nov 1 2014, In : Human molecular genetics. 23, 21, p. 5827-5837 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials

Grunwald, J. E., Daniel, E., Huang, J., Ying, G. S., Maguire, M. G., Toth, C. A., Jaffe, G. J., Fine, S. L., Blodi, B., Klein, M. L., Martin, A. A., Hagstrom, S. A. & Martin, D. F., Jan 1 2014, In : Ophthalmology. 121, 1, p. 150-161 12 p.

Research output: Contribution to journalArticle

299 Scopus citations

Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression AREDS2 report no. 3

Chew, E. Y., Clemons, T. E., SanGiovanni, J. P., Danis, R. P., Ferris, F. L., Elman, M. J., Antoszyk, A. N., Ruby, A. J., Orth, D., Bressler, S. B., Fish, G. E., Hubbard, G. B., Klein, M. L., Chandra, S. R., Blodi, B. A., Domalpally, A., Friberg, T., Wong, W. T., Rosenfeld, P. J., Agrón, E. & 3 others, Toth, C. A., Bernstein, P. S. & Sperduto, R. D., Feb 1 2014, In : JAMA ophthalmology. 132, 2, p. 142-149 8 p.

Research output: Contribution to journalArticle

168 Scopus citations
2013

Baseline predictors for one-year visual outcomes with ranibizumab or bevacizumab for neovascular age-related macular degeneration

Ying, G. S., Huang, J., Maguire, M. G., Jaffe, G. J., Grunwald, J. E., Toth, C., Daniel, E., Klein, M., Pieramici, D., Wells, J. & Martin, D. F., Jan 1 2013, In : Ophthalmology. 120, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

171 Scopus citations

Genetic determinants of macular pigments in women the carotenoids in age-related eye disease study

Meyers, K. J., Johnson, E. J., Bernstein, P. S., Iyengar, S. K., Engelman, C. D., Karki, C. K., Liu, Z., Igo, R. P., Truitt, B., Klein, M. L., Snodderly, D. M., Blodi, B. A., Gehrs, K. M., Sarto, G. E., Wallace, R. B., Robinson, J., LeBlanc, E. S., Hageman, G., Tinker, L. & Mares, J. A., 2013, In : Investigative Ophthalmology and Visual Science. 54, 3, p. 2333-2345 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Genetic evidence for role of carotenoids in age-related macular degeneration in the carotenoids in age-related eye disease study (CAREDS)

Meyers, K. J., Mares, J. A., Igo, R. P., Truitt, B., Liu, Z., Millen, A. E., Klein, M., Johnson, E. J., Engelman, C. D., Karki, C. K., Blodi, B., Gehrs, K., Tinker, L., Wallace, R., Robinson, J., LeBlanc, E. S., Sarto, G., Bernstein, P. S., SanGiovanni, J. P. & Iyengar, S. K., Dec 17 2013, In : Investigative Ophthalmology and Visual Science. 55, 1, p. 587-599 13 p.

Research output: Contribution to journalArticle

69 Scopus citations

Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4

Chew, E. Y., SanGiovanni, J. P., Ferris, F. L., Wong, W. T., Agron, E., Clemons, T. E., Sperduto, R., Danis, R., Chandra, S. R., Blodi, B. A., Domalpally, A., Elman, M. J., Antoszyk, A. N., Ruby, A. J., Orth, D., Bressler, S. B., Fish, G. E., Hubbard, G. B., Klein, M. L., Friberg, T. R. & 3 others, Rosenfeld, P. J., Toth, C. A. & Bernstein, P., Jul 1 2013, In : JAMA ophthalmology. 131, 7, p. 843-850 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial

Chew, E. Y., Clemons, T. E., SanGiovanni, J. P., Danis, R., Ferris, F. L., Elman, M., Antoszyk, A., Ruby, A., Orth, D., Bressler, S., Fish, G., Hubbard, B., Klein, M., Chandra, S., Blodi, B., Domalpally, A., Friberg, T., Wong, W., Rosenfeld, P., Agron, E. & 3 others, Toth, C., Bernstein, P. & Sperdut, R., May 15 2013, In : JAMA - Journal of the American Medical Association. 309, 19, p. 2005-2015 11 p.

Research output: Contribution to journalArticle

588 Scopus citations

Pharmacogenetics for genes associated with age-related macular degeneration in the comparison of AMD treatments trials (CATT)

Hagstrom, S. A., Ying, G. S., Pauer, G. J. T., Sturgill-Short, G. M., Huang, J., Callanan, D. G., Kim, I. K., Klein, M. L., Maguire, M. G. & Martin, D. F., Mar 1 2013, In : Ophthalmology. 120, 3, p. 593-599 7 p.

Research output: Contribution to journalArticle

105 Scopus citations

Seven new loci associated with age-related macular degeneration

Fritsche, L. G., Chen, W., Schu, M., Yaspan, B. L., Yu, Y., Thorleifsson, G., Zack, D. J., Arakawa, S., Cipriani, V., Ripke, S., Igo, R. P., Buitendijk, G. H. S., Sim, X., Weeks, D. E., Guymer, R. H., Merriam, J. E., Francis, P. J., Hannum, G., Agarwal, A., Armbrecht, A. M. & 136 others, Audo, I., Aung, T., Barile, G. R., Benchaboune, M., Bird, A. C., Bishop, P. N., Branham, K. E., Brooks, M., Brucker, A. J., Cade, W. H., Cain, M. S., Campochiaro, P. A., Chan, C. C., Cheng, C. Y., Chew, E. Y., Chin, K. A., Chowers, I., Clayton, D. G., Cojocaru, R., Conley, Y. P., Cornes, B. K., Daly, M. J., Dhillon, B., Edwards, A. O., Evangelou, E., Fagerness, J., Ferreyra, H. A., Friedman, J. S., Geirsdottir, A., George, R. J., Gieger, C., Gupta, N., Hagstrom, S. A., Harding, S. P., Haritoglou, C., Heckenlively, J. R., Holz, F. G., Hughes, G., Ioannidis, J. P. A., Ishibashi, T., Joseph, P., Jun, G., Kamatani, Y., Katsanis, N., N Keilhauer, C., Khan, J. C., Kim, I. K., Kiyohara, Y., Klein, B. E. K., Klein, R., Kovach, J. L., Kozak, I., Lee, C. J., Lee, K. E., Lichtner, P., Lotery, A. J., Meitinger, T., Mitchell, P., Mohand-Saïd, S., Moore, A. T., Morgan, D. J., Morrison, M. A., Myers, C. E., Naj, A. C., Nakamura, Y., Okada, Y., Orlin, A., Ortube, M. C., Othman, M. I., Pappas, C., Park, K. H., Pauer, G. J. T., Peachey, N. S., Poch, O., Priya, R. R., Reynolds, R., Richardson, A. J., Ripp, R., Rudolph, G., Ryu, E., Sahel, J. A., Schaumberg, D. A., Scholl, H. P. N., Schwartz, S. G., Scott, W. K., Shahid, H., Sigurdsson, H., Silvestri, G., Sivakumaran, T. A., Smith, R. T., Sobrin, L., Souied, E. H., Stambolian, D. E., Stefansson, H., Sturgill-Short, G. M., Takahashi, A., Tosakulwong, N., Truitt, B. J., Tsironi, E. E., Uitterlinden, A. G., Van Duijn, C. M., Vijaya, L., Vingerling, J. R., Vithana, E. N., Webster, A. R., Wichmann, H. E., Winkler, T. W., Wong, T. Y., Wright, A. F., Zelenika, D., Zhang, M., Zhao, L., Zhang, K., Klein, M. L., Hageman, G. S., Lathrop, G. M., Stefansson, K., Allikmets, R., Baird, P. N., Gorin, M. B., Wang, J. J., Klaver, C. C. W., Seddon, J. M., Pericak-Vance, M. A., Iyengar, S. K., Yates, J. R. W., Swaroop, A., Weber, B. H. F., Kubo, M., Deangelis, M. M., Léveillard, T., Thorsteinsdottir, U., Haines, J. L., Farrer, L. A., Heid, I. M. & Abecasis, G. R., Apr 2013, In : Nature genetics. 45, 4, p. 433-439 7 p.

Research output: Contribution to journalArticle

483 Scopus citations
2012

Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration

Wei, L., Liu, B., Tuo, J., Shen, D., Chen, P., Li, Z., Liu, X., Ni, J., Dagur, P., Sen, H. N., Jawad, S., Ling, D., Park, S., Chakrabarty, S., Meyerle, C., Agron, E., Ferris, F. L., Chew, E. Y., McCoy, J. P., Blum, E. & 6 others, Francis, P. J., Klein, M. L., Guymer, R. H., Baird, P. N., Chan, C. C. & Nussenblatt, R. B., Nov 29 2012, In : Cell Reports. 2, 5, p. 1151-1158 8 p.

Research output: Contribution to journalArticle

98 Scopus citations

The related transcriptional enhancer factor-1 Isoform, TEAD4216, can repress vascular endothelial growth factor expression in mammalian cells

Appukuttan, B., McFarland, T. J., Stempel, A., Kassem, J. B., Hartzell, M., Zhang, Y., Bond, D., West, K., Wilson, R., Stout, A., Pan, Y., Ilias, H., Robertson, K., Klein, M. L., Wilson, D., Smith, J. R. & Stout, J. T., Jun 22 2012, In : PloS one. 7, 6, e31260.

Research output: Contribution to journalArticle

1 Scopus citations
2011

A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration

Sivakumaran, T. A., Igo, R. P., Kidd, J. M., Itsara, A., Kopplin, L. J., Chen, W., Hagstrom, S. A., Peachey, N. S., Francis, P. J., Klein, M. L., Chew, E. Y., Ramprasad, V. L., Tay, W. T., Mitchell, P., Seielstad, M., Stambolian, D. E., Edwards, A. O., Lee, K. E., Leontiev, D. V., Jun, G. & 20 others, Wang, Y., Tian, L., Qiu, F., Henning, A. K., LaFramboise, T., Sen, P., Aarthi, M., George, R., Raman, R., Das, M. K., Vijaya, L., Kumaramanickavel, G., Wong, T. Y., Swaroop, A., Abecasis, G. R., Klein, R., Klein, B. E. K., Nickerson, D. A., Eichler, E. E. & Iyengar, S. K., Oct 12 2011, In : PloS one. 6, 10, e25598.

Research output: Contribution to journalArticle

37 Scopus citations
30 Scopus citations

Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration

Liu, B., Wei, L., Meyerle, C., Tuo, J., Sen, H. N., Li, Z., Chakrabarty, S., Agron, E., Chan, C. C., Klein, M. L., Chew, E., Ferris, F. & Nussenblatt, R. B., Jul 15 2011, In : Journal of translational medicine. 9, 1, 111.

Research output: Contribution to journalArticle

94 Scopus citations

Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies

Mckay, G. J., Patterson, C. C., Chakravarthy, U., Dasari, S., Klaver, C. C., Vingerling, J. R., Ho, L., de Jong, P. T. V. M., Fletcher, A. E., Young, I. S., Seland, J. H., Rahu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A. D., Sofat, R., Dean, M., Sawitzke, J. & 30 others, Seddon, J. M., Peter, I., Webster, A. R., Moore, A. T., Yates, J. R. W., Cipriani, V., Fritsche, L. G., Weber, B. H. F., Keilhauer, C. N., Lotery, A. J., Ennis, S., Klein, M. L., Francis, P. J., Stambolian, D., Orlin, A., Gorin, M. B., Weeks, D. E., Kuo, C. L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G. R., Wright, A. F., Hayward, C., Baird, P. N., Guymer, R. H., Attia, J., Thakkinstian, A. & Silvestri, G., Dec 2011, In : Human mutation. 32, 12, p. 1407-1416 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Healthy lifestyles related to subsequent prevalence of age-related macular degeneration

Mares, J. A., Voland, R. P., Sondel, S. A., Millen, A. E., LaRowe, T., Moeller, S. M., Klein, M. L., Blodi, B. A., Chappell, R. J., Tinker, L., Ritenbaugh, C., Gehrs, K. M., Sarto, G. E., Johnson, E., Snodderly, D. M. & Wallace, R. B., Apr 1 2011, In : Archives of ophthalmology. 129, 4, p. 470-480 11 p.

Research output: Contribution to journalArticle

90 Scopus citations

Risk assessment model for development of advanced age-related macular degeneration

Klein, M. L., Francis, P. J., Ferris, F. L., Hamon, S. C. & Clemons, T. E., Dec 1 2011, In : Archives of ophthalmology. 129, 12, p. 1543-1550 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Vitamin D status and early age-related macular degeneration in postmenopausal women

Millen, A. E., Voland, R., Sondel, S. A., Parekh, N., Horst, R. L., Wallace, R. B., Hageman, G. S., Chappell, R., Blodi, B. A., Klein, M. L., Gehrs, K. M., Sarto, G. E. & Mares, J. A., Apr 1 2011, In : Archives of ophthalmology. 129, 4, p. 481-489 9 p.

Research output: Contribution to journalArticle

83 Scopus citations
2010

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

Chen, W., Stambolian, D., Edwards, A. O., Branham, K. E., Othman, M., Jakobsdottir, J., Tosakulwong, N., Pericak-Vance, M. A., Campochiaro, P. A., Klein, M. L., Tan, P. L., Conley, Y. P., Kanda, A., Kopplin, L., Li, Y., Augustaitis, K. J., Karoukis, A. J., Scott, W. K., Agarwal, A., Kovach, J. L. & 46 others, Schwartz, S. G., Postel, E. A., Brooks, M., Baratz, K. H., Brown, W. L., Brucker, A. J., Orlin, A., Brown, G., Ho, A., Regillo, C., Donoso, L., Tian, L., Kaderli, B., Hadley, D., Hagstrom, S. A., Peachey, N. S., Klein, R., Klein, B. E. K., Gotoh, N., Yamashiro, K., Ferris, F., Fagerness, J. A., Reynolds, R., Farrer, L. A., Kim, I. K., Miller, J. W., Cortón, M., Carracedo, A., Sanchez-Salorio, M., Pugh, E. W., Doheny, K. F., Brion, M., DeAngelis, M. M., Weeks, D. E., Zack, D. J., Chew, E. Y., Heckenlively, J. R., Yoshimura, N., Iyengar, S. K., Francis, P. J., Katsanis, N., Seddon, J. M., Haines, J. L., Gorin, M. B., Abecasis, G. R. & Swaroop, A., Apr 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 16, p. 7401-7406 6 p.

Research output: Contribution to journalArticle

371 Scopus citations

Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration

Kopplin, L. J., Igo, R. P., Wang, Y., Sivakumaran, T. A., Hagstrom, S. A., Peachey, N. S., Francis, P. J., Klein, M. L., Sangiovanni, J. P., Chew, E. Y., Pauer, G. J. T., Sturgill, G. M., Joshi, T., Tian, L., Xi, Q., Henning, A. K., Lee, K. E., Klein, R., Klein, B. E. K. & Iyengar, S. K., Dec 1 2010, In : Genes and Immunity. 11, 8, p. 609-621 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Natural History of Drusenoid Pigment Epithelial Detachment in Age-Related Macular Degeneration: Age-Related Eye Disease Study Report No. 28

Cukras, C., Agrón, E., Klein, M. L., Ferris, F. L., Chew, E. Y., Gensler, G. & Wong, W. T., Mar 1 2010, In : Ophthalmology. 117, 3, p. 489-499 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Progression of geographic atrophy and genotype in age-related macular degeneration

Klein, M. L., Ferris, F. L., Francis, P. J., Lindblad, A. S., Chew, E. Y., Hamon, S. C. & Ott, J., 2010, In : Ophthalmology. 117, 8, p. 1554-1559.e1

Research output: Contribution to journalArticle

48 Scopus citations
2009

Change in area of geographic atrophy in the age-related eye disease study: AREDS report number 26

Lindblad, A. S., Lloyd, P. C., Clemons, T. E., Gensler, G. R., Ferris, F. L., Klein, M. L. & Armstrong, J. R., Sep 1 2009, In : Archives of ophthalmology. 127, 9, p. 1168-1174 7 p.

Research output: Contribution to journalArticle

124 Scopus citations

Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration

SanGiovanni, J. P., Arking, D. E., Iyengar, S. K., Elashoff, M., Clemons, T. E., Reed, G. F., Henning, A. K., Sivakumaran, T. A., Xu, X., DeWan, A., Agrón, E., Rochtchina, E., Sue, C. M., Wang, J. J., Mitchell, P., Hoh, J., Francis, P. J., Klein, M. L., Chew, E. Y. & Chakravarti, A., May 12 2009, In : PloS one. 4, 5, e5508.

Research output: Contribution to journalArticle

68 Scopus citations

Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss

Francis, P. J., Hamon, S. C., Ott, J., Weleber, R. G. & Klein, M. L., May 1 2009, In : Journal of medical genetics. 46, 5, p. 300-307 8 p.

Research output: Contribution to journalArticle

104 Scopus citations
2008

Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the carotenoids in the age-related eye disease study (CAREDS), an ancillary study of the Women's Health Initiative

Moeller, S. M., Voland, R., Tinker, L., Blodi, B. A., Klein, M. L., Gehrs, K. M., Johnson, E. J., Snodderly, D. M., Wallace, R. B., Chappell, R. J., Parekh, N., Ritenbaugh, C. & Mares, J. A., Mar 1 2008, In : Archives of ophthalmology. 126, 3, p. 354-364 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

CFH and LOC387715/ARMS2 Genotypes and Treatment with Antioxidants and Zinc for Age-Related Macular Degeneration

Klein, M. L., Francis, P. J., Rosner, B., Reynolds, R., Hamon, S. C., Schultz, D. W., Ott, J. & Seddon, J. M., Jun 1 2008, In : Ophthalmology. 115, 6, p. 1019-1025 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Clinicopathologic correlation of retinal angiomatous proliferation

Monson, D. M., Smith, J. R., Klein, M. L. & Wilson, D. J., Dec 1 2008, In : Archives of ophthalmology. 126, 12, p. 1664-1668 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population

Francis, P. J., Zhang, H., DeWan, A., Hoh, J. & Klein, M. L., Aug 4 2008, In : Molecular vision. 14, p. 1395-1400 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Macular Pigment Density and Age-Related Maculopathy in the Carotenoids in Age-Related Eye Disease Study. An Ancillary Study of the Women's Health Initiative

LaRowe, T. L., Mares, J. A., Snodderly, D. M., Klein, M. L., Wooten, B. R. & Chappell, R., May 2008, In : Ophthalmology. 115, 5, p. 876-883.e1

Research output: Contribution to journalArticle

61 Scopus citations