Michael Klein

Professor

  • 14393 Citations
  • 60 h-Index
1974 …2019
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Research Output 1974 2019

  • 14393 Citations
  • 60 h-Index
  • 155 Article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019
2 Citations (Scopus)

Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Grassmann, F., Harsch, S., Brandl, C., Kiel, C., Nürnberg, P., Toliat, M. R., Fleckenstein, M., Pfau, M., Schmitz-Valckenberg, S., Holz, F. G., Chew, E. Y., Swaroop, A., Ratnapriya, R., Klein, M., Mulyukov, Z., Zamiri, P. & Weber, B. H. F., Jan 1 2019, In : JAMA ophthalmology.

Research output: Contribution to journalArticle

Geographic Atrophy
Macular Degeneration
Genome
Growth
Genes
Complement Factor H
Lutein
Eye Diseases
Omega-3 Fatty Acids
Macular Degeneration

Precursors and Development of Geographic Atrophy with Autofluorescence Imaging: Age-Related Eye Disease Study 2 Report Number 18

Age-Related Eye Disease Study 2 Research Group, Sep 1 2019, In : Ophthalmology Retina. 3, 9, p. 724-733 10 p.

Research output: Contribution to journalArticle

Geographic Atrophy
Eye Diseases
Optical Imaging
2018
8 Citations (Scopus)

Genome-wide analysis of disease progression in age-related macular degeneration

AREDS2 Research Group, Mar 1 2018, In : Human Molecular Genetics. 27, 5, p. 929-940 12 p.

Research output: Contribution to journalArticle

Macular Degeneration
Disease Progression
Genome
Geographic Atrophy
Choroidal Neovascularization
1 Citation (Scopus)

Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17

Yu, J. J., Agrón, E., Clemons, T. E., Domalpally, A., van Asten, F., Keenan, T. D., Cukras, C., Chew, E. Y., Chew, E. Y., Ferris, F. L., SanGiovanni, J. P., Agrón, E., Clemons, T., Lindblad, A., Lindblad, R., Shah, N., Sperduto, R., McBee, W., Gensler, G., Harrington, M. & 982 others, Henning, A., Jones, K., Thotapally, K., Tull, D., Watson, V., Williams, K., Gentry, C., Kaufman, F., Morrison, C., Saverino, E., Schenning, S., Blodi, B., Davis, M., Domalpally, A., Glander, K., Guilfoil, G., Hubbard, L. D., Johnson, K., Nardi, B., Neider, M., Robinson, N., Rosensteel, E., Wabers, H., Zhang, G., Capone, A., Dass, B., Drenser, K., Garretson, B. R., Hassan, T. S., Trese, M., Williams, G. A., Wolfe, J., Bell, T., Zajechowski, M., Bezaire, D., McIver, F., Medina, A., Pagett, J., Smith, S. H., Swartz, L., Treuter, T., Antoszyk, A., Brown, J., Browning, D. J., Holland, W., Karow, A., Stalford, K., Price, A., Ennis, S., Fredenberg, S., Herby, J., Balasubramaniam, U., Clark, L., McClain, D., McOwen, M., Watson, L., Klein, M., Bailey, S., Hwang, T. J., Lauer, A. A., Stout, J. T., McCollum, P., Johnson, M., Rice, P. B., Kim, I., Loewenstein, J., Miller, J., Sobrin, L., Young, L., Sullivan, J., Houlihan, P., Merry, L., Lane, A. M., Bator, U. L., Evans, C., Brett, S., Callahan, C., Grillo, M., Walsh, D., Zimmerman, K. L., Anand, R., Coors, L. E., Fuller, D. G., Spencer, R., Wang, R. C., Duignan, K., Arceneaux, S., Aguado, H., Hesse, N., Mackens, M., Swan, B., Wong, W. T., Cukras, C., Dalal, M., Jacobs-El, N., Meyerle, C., Nicholson, B., Wiley, H., Shimel, K. H., Garced, A., Oparah, J., Short, G., Temple, A., Ayukawa, B., Foster, G., Hayes, D., Koutsandreas, D., Nashwinter, R., Rowan, J., Bono, M., Cunningham, D., Palmer, M., Zetina, A., Orth, D. H., Rezaei, K., Civantos, J., Hasan, S., Packo, K., Figliulo, C., Stanberry, P., Farmer, T., Nelson, K., Townsend-Patrick, S., Rosenfeld, P., Chen, R., Doshi, R., Dubovy, S., Kim, B. T., Lowrance, M., Moshfeghi, A., Nahas, Z., Schienbaum, G., Vishak, J., Weng, C., Yehoshua, Z., Rodriguez, B., Rebimbas, J., Gleichauf, J., Kicak, M., Mena, J., Odem, T., Sferza-Camp, E., Disgdiertt, A., Oramas, J., Rams, I., Thatcher, S., Bressler, S. B., Bressler, N. M., Finkelstein, D., Sherman, S. H., Solomon, S., Ying, H. S., Denbow, R., Phillips, D., Radcliffe, E., Belt, J., Cain, D., Emmert, D., Herring, M., McDonald, J., Hubbard, G. B., Bergstrom, C. S., Cribbs, B., Hendrick, A., Johnson, B., Laird, P., Mehta, S., Olsen, T., Townsend, J., Yan, J., Yeh, S., Curtis, L., Brower, J., Yi, H., Dobbs, J. R., Jordan, D., Elman, M. J., Liss, R. A., Starr, J. A., Belz, J., Putzulo, C., Coffey, T., Davis, A., Singletary, P., Andreani, G. S., Cain, T., Ketner, D., Sotirakos, P., Chandra, S., Blodi, B. A., Altaweel, M. M., Danis, R. P., Gottlieb, J. L., Ip, M., Klein, R., Nork, T. M., Stevens, T. S., Burke, K., Olson, S., Dietzman, K., Soderling, B., Somers, G., Wealti, A., Krolnik, D., Peterson, J., Reed, S., Friberg, T., Eller, A., Gallagher, D., Labriola, L., Pokrifka, M., Gedansky, A., Anthony, N., Grzybowski, C., Matthews, D., Murajda-Jumba, S., Toro, J., Callanan, D. G., Solley, W. A., Williams, P., Lash, S., Boleman, B., Dock, C., Fish, G. E., Shami, M., Arrington, B., Meeks, A., Margherio, A. R., Raphaelian, P., Markus, D., Langdon, J., Truax, E., Lewis, S., Terry, B., Ruby, A. J., Noffke, A., Oh, K., Sarrafizadeh, R., Sneed, S., Hammersley, J., Neal, S., Doran, M., Jones, N., Preston, L., Jessick, H., Marsh, T. T., Tolentino, M., Berger, A., Hamilton, R., Misch, D., Moon, S. J., Sutherland, D., Dilts, V., Henderson, S., Medina, E., Trueman, D., Holm, L., Strickland, J., Ie, D., Lipkowitz, J. L., Shah, K. B., Geraghty, S., Sannazzaro, B., Harper, M., Bayer, K., Lansing, M. B., Fox, L. B., Lee, R., Stallman, J. B., Jacobson, M., Koh, S., Lampert, S., Miller, J., Rivellese, M., Sharma, A., Stoltz, R. A., Vanderveldt, S., Marcus, L., Hendricks, S., Hollman, R., Betanzos, G., Ellorin, L., Fulbright, S., McCormick, D., Edwards, P. A., Hall, J., Monk, M., Gutkowski, M., Mazurek, M., Murphy, J., Gusas, K., Moffett, C., Burley, D., Chesney, N., Kilgo, K., Rusinek, B., Stern, B., Troszak, T., Baker-Levingston, R., Baker, C. W., Caldwell, T., Walker, T., Lambert, L. F., Martin, T., Palmer, M. J., Williams, T., Novak, M. A., Coney, J., Miller, D. G., Pendergast, S., Singerman, L., Zakov, N., Zegarra, H., DuBois, K., Rath, S., Revella, L., Brink, T., Drury, K., Hogue, L., Ilc, M., Keller, C., McNamara, E., Tanner, V., Cunningham, T., DuBois, J., Greanoff, G., Nitzsche, T., Smith-Brewer, S., Isernhagen, R. D., Kitchens, J. W., Stone, T. W., Wood, W. J., Holcomb, D., Therrien, V., Buck, M., Van Arsdall, J., Slade, E., Schneiderman, T. E., Spinak, D. J., Gaedke, J., Brown, H. D., Helgren, D., Pangelinan, J. G., Halperin, L., Anagnoste, S., Dhalla, M., Rosenberg, K., Taney, B., Thompson, W. S., Lopez, J., Hamlin, M., Lopez, M., Mariano, J., Quinchia, E., Aramayo, P., Veksler, R., Lee, M., Dreyer, R., Handelman, I., Ma, C., Peters, M., Hobbs, S., Milliron, A., Kopfer, M., Connaughton, M., Hoerner, A. C., Logan, R. J., Wohlsein, H. J., Boyer, D., Chu, T. G., Dayani, P., Liao, D., Novack, R. L., Rahhal, F. M., Roe, R., Tabandeh, H., Bayramyan, J., Gasparyan, T., Hoang, C., Kurokouchi, J., Lo, T. E., Ngo, R., Nguyen, M. A., Peyton, M., Yoon, C., Sierra, J., Zamboni, A., Kessinger, J., Protacio, E., Smucker, A., Rath, P., Bergren, R., Doft, B., Liu, J., Olsen, K., Merlotti, L., Ingram, W., Marfisi, K., Yeckel, K., Carmelo, H. S., Fec, A., McBroom, K., Steinberg, D., Levy, M., Abrams, J., Chen, M., Torres, W., Jelemensky, P., Prybylski, M., Raphael, T., Appleby, D., Rodman, C., Sneath, M., Rosa, R. H., Hoelscher, V., Castano, A., Parker, J., Hoskins, J., Anderson, N., Googe, J., McMillan, T. A., Miller, J., Perkins, S., Oliver, K., Beerbower, J., Gilliland, B., Hunt, C., Jacobus, M., Lince, R., Morris, C., Oelrich, S., Whetstone, J., Chan, C. K., Lin, S., Walther, K., Gonzales, T., Myers, L., Huff, K., Brown, D. M., Chen, E., Benz, M. S., Fish, R. H., Kim, R. Y., Major, J., Wong, T. P., Wycoff, C., Cone, C., Gilaspia, D. G., Landaverde, N., Smith, R., Zamora, D., Sneed, V., Vela, M., Kegley, E., Greven, C., Kurup, S., Richards, C., Slusher, M., Everhart, C., Fish, J., Miller, D., Tyler, M., Lujan, B., Fu, A. D., Johnson, R. N., Lujan, B., McDonald, H. R., Rodriguez, R., Ansari, N., Joaquin, J., Linares, S., Lopez, L., Sabio, J., Grout, S., Indermill, C., Urias, Y., Zimmerman, R., Margulies, L., Schmidt, S. J., Meier, J. L., Hadley, S. L., Rosenthal, W., Johnson, B., Swafford, L., Shields, R., Varner, R. S., Rosen, R., Gentile, R., Rivas, M., Tai, K. W., Carrasquillo-Boyd, W., Masini, R., Stoller, G., Carnevale, K., LaRosa, D. M., Burger, B., Conway, T., Del Castillo, C., Diaz, J., Jones, S., Mondoc, N., Balfour, C., Vitha, C. H., Lutz, J., McGinley, B., El Baba, F., Lavorna, A. M., Jones, R., Lewis, J., Tenzler, R., Salvas-Mladek, M., Van Kesteren, D., McLean, W. C., Bridges, W. Z., Stone, C., Ammons, D., Lamy, M., Menzel, A., Raymer, L. D., Campbell, B., Hawkins, L., Rickman, L., Sherlin, L., Price, P., Sinyai, A., Kingsley, R., Bradford, R. H., Leonard, R. E., Icks, S., Bergman, V., Ross, B., Burris, R., Butt, A., Richmond, R., Lyon, A., Gill, M., Jampol, L., Mizra, R., Rozenbajgier, Z., Chapman, J., Kaminski, L., Degillio, A., Simjanoski, E., Heier, J., Cho, H., Cleary, T. S., Goldman, D., Shah, C., Topping, T., Weber, M., Wiegand, T., Schindelheim, J., Bankert, J., Stone, J., Nowak, A., Chong, S., Williams, L., Bennett, S., Donovan, D., Graham, M., Jones, C., Fung, A., Bayabo, J. K., Bosch, R., Cruz, E., Emerson, A., Fleming, A., Barsness, D., Rodriguez, J., Soboleva, M., Scott, I. U., Bowie, E., Neely, K. A., Quillen, D. A., Walter, L., Bennett, T., Strong, J., Wells, J., Clark, L., Miller, P., Taylor, M., Swinford, T., Spivey, R., Banach, M., Ho, L., Lanning, R., Pheasant, T. R., Prensky, J. G., Truong, S., Teatsworth, J., Dietrich, M., Wasilus, A., Miller, A., Rakes, M., Slagle, T., Richards, M., Schuessler, P., Stover, L., Beer, P., Falk, N. S., Shannon, M. B., Olmeda, J., Berdeen, D., Fisher, J. F., Folk, J., Russell, S., Taylor, B., Hinz, C., Walshire, J., Stockman, H., Critser, B., Karakas, S., Montague, C., Verdick, R., Gupta, O., Maguire, J., Brady, C., DeCroos, F. C., Dollin, M., Garg, S., Gerstenblith, A., Haller, J., Ho, A. C., Hsu, J., Kaiser, R., Pitcher, J., Regillo, C., Shah, R., Spirn, M., Tasman, W., Vander, J., Senderowitsch, N., Formoso, M., Markun, M., George, C., Centinaro, C., Grande, L., Carey, S., Liebenbaum, E., Sadda, S. V., Humayun, M., Sierra, R., Corona, E., Padilla, M., Nu, M., Ramos, S., Barnett, C., Currie, G., Gottlieb, C., Garfinkel, R., Berinstein, D., Colyer, M., Deegan, W., Min-Shyue Lai, M., Murphy, R., Osman, M., Rivers, M., Sanders, R., von Fricken, M. A., Oliver, D., Kirshon, J., Snowden, T. A., Blondo, T., Cronise, A., Denny, V., Mendez, K., Newgen, J., Davis, J., Flory, M., Frantz, R., Murphy, B., Rauch, S., Kim, J. E., Bachman, J., Connor, T. B., Han, D. P., Stepian, K., Weinberg, D. V., Wirostko, W. J., Packard, K., Kaczanowski, T., Williams, V., Barwick, V., Flanders, J., Backes, D., Beringer, J., Keller, K., Selchert, K., Bernstein, P., Teske, M., Vitale, A., Allman, S., Carlstrom, B., Wegner, K., Haroldsen, A., Harrison, D., Fry, C., Gilman, J., Jenkins, G., Morris, P., Rauser, M., Fan, J., Suthar, M., Santiago, G., Halsey, K. R., Quesada, C., Kiernan, W., Knabb, J., Lewis, R. A., Dorenbach, C., Spencer, S., Barnett, D., Morales, J., Fishburne, B. C., Gross, J. G., Magee, M. A., Flowers, A., McDowell, A., Price, R., Huang, S., Tang, J., Wilker, S., Hornsby, C., Ferguson, L., Krogstad, K., Adamovsky, R., Allchin, P., Carlton, K., Clow, C., Sholtis, K., Burke, S., Harrod, M., Hrvatin, S., Pankhurst, G., Sabates, N. R., Cassell, M., Desai, K., Poulose, A., Sabates, F., Chen, Y., Gallimore, G., Konior, Y., Kim, N., Uwaydat, S., Troillett, D., Aletter, K., Frank, R. N., Abrams, G., Puklin, J., Tewari, A., Milanovic, C., Bailey, M., Griffith, D., McDonald, D., Morehead, K., Sadikovic, Z., Schillace, L., Silvis, E., Joondeph, B., Christmas, N., Johnson, D., Kimura, A., Liu, M., Petty, S., Zilis, J., Benitez, J., Catlett, C. B., Fluegel, E., Mowry, S., Nguyen, H., Reflow, D., Houghton, O. M., Garg, S., Landers, M. B., Meredith, T., Barnhart, S., Karmalkar, M., Cantrell, D., Esquejo-Leon, R. L., Manor, L., Pope, S., Stines, D., Stokely, A., Hainsworth, D., Helming, D., Eichelberger, D., Leaton, M. P., Hamm, C., Chaum, E., Iannaccone, A., Jennings, B., Murray, T., Mastellone, J., Millay, R., Kim, B., Goddard, T., Beaudette, L. J., Changelian-Aitken, N., Corrada, F., Dubuque, J., Iezzi, R., Bakri, S. J., Pulido, J. S., Vogen, D., Nielsen, R., Berg, K., Burrington, J., Howard, S., Overend, J., Krason, Z., Lewison, D., Link, T., Blinder, K. J., Engelbrecht, N. E., Grand, M. G., Joseph, D. P., Shah, G. K., Smith, B., Thomas, M., Weeks, R., Boyd, L., Gabel, D., Adelman, R., Huang, J., Kempton, J., Parnes, A., Dupont, J., Perotti, E., Donaldson, V., Fong, K., Ossorio, P., Agarwal, A., Sternberg, P., Owings, S., Adkins, T., Lok, E., Munn, G., Skellie, B., Bhagat, N., Roy, M. S., Zarbin, M., Fay, C., Lazar, M., Malpica, B., Mikheyav, T., Ulanski, L., Lim, J., Niec, M., Johnson, T., Ovando, Y., Carroll, C. N., Janowicz, M., Schwartz, S., Cupp, D., Gorin, M., Heilweil, G., Hosseini, H., Hubschman, J. P., Kreiger, A., McCannel, T. Y., Pan, C., Sarraf, D., Tsui, I., Udoetek, J., Voleti, V., Hitchcock, L., Ostrick, R., Chun, M., Kageyama, J., Davila, N., Lipka, K., Shin, C., Owsley, C., Albert, M., Feist, R., Mason, J., Thomley, M., Johnson, A., Clark, M., Emond, T., Hamela, J., Marsh, A., Searcey, K., Rookard, K., He, Y. G., Ufret-Vincenty, R. L., Molai, M., Anderson, W., Horna, J., Letson, A., Cebulla, C., Chang, S., Davidorf, F., Salerno, J., Sladoje, L., Stetson, C., Perry, J., Savage, S., Toth, C., Jaffe, G., Schuman, S., Sarin, N., Crowell, J., Keaton, T., Kelly, M., Lutman, B., Skelly, M., Welch, L., Morse, L., Hunter, A., Soon-Chun Park, S., Wallace, C., Dhillon, E., Salvador, M., Holderreed, B., Chandra, K., Kaur, S., Redenbo, E., Hom, S., Cooney, M., Barbazetto, I., Klancnik, J. M., Sorenson, J. A., Yannuzzi, L., Scolaro, M., Agresta, E., Gonzalez, N., Grover, S., Chalam, K. V., Gupta, S., Lyons, C., Li, W., Patel, C., Carrion, J., Ferreyra, H., Rodriguez, A., Molina, I., Balea, G., Emory, P., Rico, M., Siqueiros, G., Brucker, A. J., Dunaief, J., Grunwald, J., Kim, B., Maguire, A. M., VanderBeek, B., Drossner, S., DuPont, J., Salvo, R., Berger, J., Devine, C., Nyberg, B., Weeney, L., DiLoreto, D., Chung, M., Davis, V., MacDowell, P., Gara, G. O., Castillo, D., Czubinski, A., Keim, M., Hardy, B., Hollar, R. G., Schueckler, L., Lyon, A. T., Weinberg, A., Shiloach, M., Pelkofer, N., Zhou, Q., McPoland, L., Apte, R., Rao, P. K., Pistorius, S., Kambarian, J., Adcock, E., Gould, S., Quinn, M., Curtis, R., Frost, A., Meyer, C. & Rathert, G., Jan 1 2018, (Accepted/In press) In : Ophthalmology.

Research output: Contribution to journalArticle

Eye Diseases
Macular Degeneration
Natural History
Confidence Intervals
Visual Acuity
8 Citations (Scopus)

Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16

AREDS2 Research Group, Dec 1 2018, In : Ophthalmology. 125, 12, p. 1913-1928 16 p.

Research output: Contribution to journalArticle

Geographic Atrophy
Eye Diseases
Macular Degeneration
2017
9 Citations (Scopus)

Bivariate analysis of age-related macular degeneration progression using genetic risk scores

Ding, Y., Liu, Y., Yan, Q., Fritsche, L. G., Cook, R. J., Clemons, T., Ratnapriya, R., Klein, M., Abecasis, G. R., Swaroop, A., Chew, E. Y., Weeks, D. E. & Chen, W., May 1 2017, In : Genetics. 206, 1, p. 119-133 15 p.

Research output: Contribution to journalArticle

Macular Degeneration
Eye Diseases
Disease Progression
Demography
Blindness
2 Citations (Scopus)

CLINICOPATHOLOGIC CORRELATION of RETINAL ANGIOMATOUS PROLIFERATION TREATED with RANIBIZUMAB

Skalet, A., Miller, A. K., Klein, M., Lauer, A. A. & Wilson, D., Aug 1 2017, In : Retina. 37, 8, p. 1620-1624 5 p.

Research output: Contribution to journalArticle

Optical Coherence Tomography
Bruch Membrane
Retinal Pigment Epithelium
Macular Degeneration
Blood Vessels
22 Citations (Scopus)

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

International AMD Genomics Consortium (IAMDGC), Mar 27 2017, In : Genome Medicine. 9, 1, 29.

Research output: Contribution to journalArticle

Genetic Pleiotropy
Macular Degeneration
Autoimmune Diseases
Lipid Metabolism Disorders
Genome
22 Citations (Scopus)

Recombinant haplotypes narrow the ARMS2/HTRA1 association signal for age-related macular degeneration

International AMD Genomics Consortium (IAMDGC), Feb 1 2017, In : Genetics. 205, 2, p. 919-924 6 p.

Research output: Contribution to journalArticle

Macular Degeneration
Haplotypes
Genes
Blindness
Genomics
2016
326 Citations (Scopus)

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P. N., Bala, E., ELee, K., Hunter, D. J., Sardell, R. J., Mitchell, P. & 142 others, Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T. E., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H. S., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., Mackey, D. A., Constable, I. J., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Tsironi, E. E., Park, K. H., Farrer, L. A., Orlin, A., Brucker, A., Li, M., Curcio, C. A., Mohand-Sa'd, S., Sahel, J. A., Audo, I., Benchaboune, M., Cree, A. J., Rennie, C. A., Goverdhan, S. V., Grunin, M., Hagbi-Levi, S., Campochiaro, P., Katsanis, N., Holz, F. G., Blond, F., Blanché, H., Deleuze, J. F. O., Igo, R. P., Truitt, B., Peachey, N. S., Meuer, S. M., Myers, C. E., Moore, E. L., Klein, R., Hauser, M. A., Postel, E. A., Courtenay, M. D., Schwartz, S. G., Kovach, J. L., Scott, W. K., Liew, G., Tan, A. G., Gopinath, B., Merriam, J. C., Smith, R. T., Khan, J. C., Shahid, H., Moore, A. T., McGrath, J. A., Laux, R., Brantley, M. A., Agarwal, A., Ersoy, L., Caramoy, A., Langmann, T., Saksens, N. T. M., Jong, E. K., Hoyng, C. B., Cain, M. S., Richardson, A. J., Martin, T., Blangero, J., Weeks, D. E., Dhillon, B., Van Duijn, C. M., Doheny, K. F., Romm, J., Klaver, C. C. W., Hayward, C., Gorin, M. B., Klein, M., Baird, P. N., Den Hollander, A. I., Fauser, S., WYates, J. R., Allikmets, R., Wang, J. J., Schaumberg, D. A., Klein, B. E. K., Hagstrom, S. A., Chowers, I., Lotery, A. J., Léveillard, T., Zhang, K., Brilliant, M. H., Hewitt, A. W., Swaroop, A., Chew, E. Y., Pericak-Vance, M. A., DeAngelis, M., Stambolian, D., Haines, J. L., Iyengar, S. K., Weber, B. H. F., Abecasis, G. R. & Heid, I. M., Feb 1 2016, In : Nature Genetics. 48, 2, p. 134-143 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Macular Degeneration
Genetic Loci
Blindness
Sample Size
2015
1 Citation (Scopus)

Author reply

Chew, E. Y., Klein, M., Clemons, T. E., Agrón, E. & Abecasis, G. R., Aug 1 2015, In : Ophthalmology. 122, 8, p. e46-e47

Research output: Contribution to journalArticle

Macular Degeneration
Dietary Supplements
Single Nucleotide Polymorphism
Proteins
30 Citations (Scopus)

Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration

Grassmann, F., Fleckenstein, M., Chew, E. Y., Strunz, T., Schmitz-Valckenberg, S., Göbel, A. P., Klein, M., Ratnapriya, R., Swaroop, A., Holz, F. G. & Weber, B. H. F., May 11 2015, In : PLoS One. 10, 5, e0126636.

Research output: Contribution to journalArticle

Geographic Atrophy
Macular Degeneration
atrophy
Planning
Growth
31 Citations (Scopus)

Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements: To test or not to test?

Chew, E. Y., Klein, M., Clemons, T. E., Agrón, E. & Abecasis, G. R., Jan 1 2015, In : Ophthalmology. 122, 1, p. 212-215 4 p.

Research output: Contribution to journalArticle

Zinc Compounds
Complement Factor H
Macular Degeneration
Genetic Testing
Dietary Supplements
25 Citations (Scopus)

Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration

Meyers, K. J., Liu, Z., Millen, A. E., Iyengar, S. K., Blodi, B. A., Johnson, E., Snodderly, D. M., Klein, M., Gehrs, K. M., Tinker, L., Sarto, G. E., Robinson, J., Wallace, R. B. & Mares, J. A., Nov 1 2015, In : Ophthalmology. 122, 11, p. 2286-2294 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Life Style
Diet
Genes
Complement Factor H

Reply

Chew, E. Y., Klein, M., Clemons, T. E., Agrón, E. & Abecasis, G. R., Oct 1 2015, In : Ophthalmology. 122, 10, p. e61-e62

Research output: Contribution to journalArticle

Macular Degeneration
Genetic Testing
Dietary Supplements
Single Nucleotide Polymorphism
Proteins

Reply

Chew, E. Y., Klein, M., Clemons, T. E., Agrón, E. & Abecasis, G. R., Oct 1 2015, In : Ophthalmology. 122, 10, p. e63

Research output: Contribution to journalArticle

Macular Degeneration
Genetic Testing
Dietary Supplements
Single Nucleotide Polymorphism
Proteins

Reply

Chew, E. Y., Klein, M., Clemons, T. E., Agrón, E. & Abecasis, G. R., Oct 1 2015, In : Ophthalmology. 122, 10, p. e58-e59

Research output: Contribution to journalArticle

Zinc Compounds
Macular Degeneration
Genetic Testing
Dietary Supplements
Single Nucleotide Polymorphism
49 Citations (Scopus)

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Willoughby, A. S., Ying, G. S., Toth, C. A., Maguire, M. G., Burns, R. E., Grunwald, J. E., Daniel, E., Jaffe, G. J., Williams, D. F., Beardsley, S., Bennett, S., Cantrill, H., Chan-Tram, C., Cheshier, H., Damato, K., Davies, J., Dev, S., Enloe, J., Follano, G., Gilbert, P. & 842 others, Johnson, J., Jones, T., Mayleben, L., Mittra, R., Moos, M., Neist, R., Oestreich, N., Quiram, P., Ramsay, R., Ryan, E., Schindeldecker, S., Snater, J., Steele, T., Selders, D., Tonsfeldt, J., Valardi, S., Fish, G. E., Aguado, H. A., Arceneaux, S., Arnwine, J., Bell, K., Bell, T., Boleman, B., Bradley, P., Callanan, D., Coors, L., Creighton, J., Crew, T., Cummings, K., Dock, C., Duignan, K., Fuller, D., Gray, K., Hendrix, B., Hesse, N., Jaramillo, D., Jost, B., Lash, S., Lonsdale, L., Mackens, M., Mutz, K., Potts, M., Sanchez, B., Snyder, W., Solley, W., Tarter, C., Wang, R., Williams, P., Perkins, S. L., Anderson, N., Arnold, A., Blais, P., Googe, J., Higdon, T. T., Hunt, C., Johnson, M., Miller, J., Moore, M., Morris, C. K., Morris, C., Oelrich, S., Oliver, K., Seitz, V., Whetstone, J., Doft, B. H., Bedel, J., Bergren, R., Borthwick, A., Conrad, P., Fec, A., Fulwylie, C., Ingram, W., Latham, S., Lester, G., Liu, J., Lobes, L., Lucko, N. M., Mechling, H., Merlotti, L., McBroom, K., Olsen, K., Puskas, D., Rath, P., Schmucker, M., Schueckler, L., Schultz, C., Shultz, H., Steinberg, D., Vyas, A., Whale, K., Yeckel, K., Orth, D. H., Arredondo, L. S., Brown, S., Ciscato, B. J., Civantos, J. M., Figliulo, C., Hasan, S., Kosinski, B., Muir, D., Nelson, K., Packo, K., Pollack, J. S., Rezaei, K., Shelton, G., Townsend-Patrick, S., Walsh, M., Richard McDonald, H., Ansari, N., Bye, A., Fu, A. D., Grout, S., Indermill, C., Johnson, R. N., Michael Jumper, J., Linares, S., Lujan, B., Munden, A., Persons, M., Rodriguez, R., Rose, J. M., Teske, B., Urias, Y., Young, S., Dreyer, R. F., Daniel, H., Connaughton, M., Handelman, I., Hobbs, S., Hoerner, C., Hudson, D., Kopfer, M., Lee, M., Lemley, C., Logan, J., Ma, C., Mallet, C., Milliron, A., Peters, M., Wohlsein, H., Pearlman, J. A., Andrews, M., Bartlett, M., Carlson, N., Cox, E., Equi, R., Gonzalez, M., Griffin, S., Hogue, F., Kennedy, L., Kryuchkov, L., Lopez, C., Lopez, D., Luevano, B., McKenna, E., Patel, A., Reed, B., Secor, N., Sison, I. R., Tsai, T., Varghis, N., Waller, B., Wendel, R., Yebra, R., Roth, D. B., Deinzer, J., Fine, H., Green, F., Green, S., Keyser, B., Leff, S., Leviton, A., Martir, A., Mosenthine, K., Muscle, S., Okoren, L., Parker, S., Prenner, J., Price, N., Rogers, D., Rosas, L., Schlosser, A., Studenko, L., Tantum, T., Wheatley, H., Trese, M. T., Aaberg, T., Bezaire, D., Bridges, C., Bryant, D., Capone, A., Coleman, M., Consolo, C., Cook, C., Dulong, C., Garretson, B., Grooten, T., Hammersley, J., Hassan, T., Jessick, H., Jones, N., Kinsman, C., Krumlauf, J., Lewis, S., Locke, H., Margherio, A., Markus, D., Marsh, T., Neal, S., Noffke, A., Oh, K., Pence, C., Preston, L., Raphaelian, P., Regan, V. R., Roberts, P., Ruby, A., Sarrafizadeh, R., Scherf, M., Scott, S., Sneed, S., Staples, L., Terry, B., Trese, M. T., Videtich, J., Williams, G., Zajechowski, M., Joseph, D. P., Blinder, K., Boyd, L., Buckley, S., Crow, M., Dinatale, A., Engelbrecht, N., Forke, B., Gabel, D., Grand, G., Grillion-Cerone, J., Holekamp, N., Kelly, C., Nobel, G., Pepple, K., Raeber, M., Kumar Rao, P., Ressel, T., Schremp, S., Sgorlon, M., Shears, S., Thomas, M., Timma, C., Vaughn, A., Walters, C., Weeks, R., Wehmeier, J., Wright, T., Berinstein, D. M., Ayyad, A., Barazi, M. K., Bickhart, E., Brady, T., Byank, L., Cronise, A., Denny, V., Dunn, C., Flory, M., Frantz, R., Garfinkel, R. A., Gilbert, W., Lai, M. M., Melamud, A., Newgen, J., Newton, S., Oliver, D., Osman, M., Sanders, R., Von Fricken, M., Dugel, P., Arenas, S., Balea, G., Bartoli, D., Bucci, J., Cornelius, J. A., Dickens, S., Doherty, D., Dunlap, H., Goldenberg, D., Jamal, K., Jimenez, N., Kavanagh, N., Kunimoto, D., Martin, J., Miner, J., Mobley, S., Park, D., Quinlan, E., Sipperley, J., Slagle, C., Smith, D., Yafchak, M., Yager, R., Flaxel, C., Bailey, S., Francis, P., Howell, C., Hwang, T., Ira, S., Klein, M., Lauer, A. A., Liesegang, T., Lundquist, A., Nolte, S., Nolte, S. K., Pickell, S., Pope, S., Rossi, J., Schain, M., Steinkamp, P., Toomey, M. D., Vahrenwald, D., West, K., Hubbard, B., Andelman, S., Bergstrom, C., Brower, J., Cribbs, B., Curtis, L., Dobbs, J., Dubois, L., Gaultney, J., Gibbs, D., Jordan, D., Leef, D., Martin, D. F., Myles, R., Olsen, T., Schwent, B., Srivastava, S., Waldron, R., Antoszyk, A. N., Balasubramaniam, U., Brooks, D., Brown, J., Browning, D., Clark, L., Ennis, S., Held, S., Helms, J. V., Herby, J., Karow, A., Leotaud, P., Massimino, C., McClain, D., McOwen, M., Mindel, J., Pereira, C., Pierce, R., Powers, M., Price, A., Rohrer, J., Sanders, J., Avery, R. L., Avery, K., Basefsky, J., Beckner, L., Castellarin, A., Couvillion, S., Giust, J., Giust, M., Nasir, M., Pieramici, D., Rabena, M., Risard, S., See, R., Smith, J., Wan, L., Bakri, S. J., Abu-Yaghi, N., Barkmeier, A., Berg, K., Burrington, J., Edwards, A., Goddard, S., Howard, S., Iezzi, R., Lewison, D., Link, T., McCannel, C. A., Overend, J., Pach, J., Ruszczyk, M., Shultz, R., Stephan, C., Vogen, D., Bradford, R. H., Bergman, V., Burris, R., Butt, A., Daniels, B., Dwiggins, C., Fransen, S., Guerrero, T., Haivala, D., Harris, A., Icks, S., Kingsley, R., Redden, L., Richmond, R., Ross, B., White, K., Youngberg, M., Topping, T. M., Chong, S., Ciotti, M., Cleary, T., Corey, E., Donovan, D., Frederick, A., Freese, L., Graham, M., Gud, N., Howard, T., Jones, M., Morley, M., Moses, K., Stone, J., Ty, R., Wiegand, T., Williams, L., Winder, B., Awh, C. C., Amonette, M., Arrindell, E., Beck, D., Busbee, B., Dilback, A., Downs, S., Guidry, A., Gutow, G., Hardin, J., Hines, S., Hutchins, E., Lacivita, K., Lester, A., Malott, L., McCain, M., Miracle, J., Moffat, K., Palazzotta, L., Robinson, K., Sonkin, P., Travis, A., Wallace, R. T., Winters, K. J., Wray, J., Harris, A. E., Bunnell, M., Crooks, K., Fitzgerald, R., Javid, C., Kew, C., Kill, E., Kline, P., Kreienkamp, J., Martinez, M., Ann Moore, R., Saavedra, E., Taylor, L., Walsh, M., Wilson, L., Ciulla, T. A., Coyle, E., Harrington, T., Harris, C., Hood, C., Kerr, I., Maturi, R., Moore, D., Morrow, S., Savage, J., Sink, B., Steele, T., Thukral, N., Wilburn, J., Walker, J. P., Banks, J., Ciampaglia, D., Dyshanowitz, D., Frederick, J., Tom Ghuman, A., Grodin, R., Kiesel, C., Knips, E., McCue, J., Ortiz, M., Peters, C., Raskauskas, P., Schoeman, E., Sharma, A., Wing, G., Youngblood, R., Chandra, S. R., Altaweel, M., Blodi, B., Burke, K., Dietzman, K. A., Gottlieb, J., Knutson, G., Krolnik, D., Michael Nork, T., Olson, S., Peterson, J., Reed, S., Soderling, B., Somers, G., Stevens, T., Wealti, A., Bearelly, S., Branchaud, B., Bryant, J. W., Crowell, S., Fekrat, S., Gammage, M., Harrison, C., Jones, S., McClain, N., McCuen, B., Mruthyunjaya, P., Queen, J., Sarin, N., Skalak, C., Skelly, M., Suner, I., Tomany, R., Welch, L., Park, S. S., Cassidy, A., Chandra, K., Good, I., Imson, K., Kaur, S., Metzler, H., Morse, L., Redenbo, E., Salvador, M., Telander, D., Thomas, M., Wallace, C., Barr, C. C., Battcher, A., Bottorff, M., Chasteen, M., Clark, K., Denning, D., Schoen, D., Schultz, A., Tempel, E., Wheeler, L., Whittington, G. K., Stone, T. W., Blevins, T., Buck, M., Cruz, L., Heath, W., Holcomb, D., Isernhagen, R., Kidd, T., Kitchens, J., Sears, C., Slade, E., Van Arsdall, J., Vanhoose, B., Wolfe, J., Wood, W., Zilis, J., Crooks, C., Disney, L., Liu, M., Petty, S., Sall, S., Folk, J. C., Aly, T., Brotherton, A., Critser, D., Hinz, C. J., Karakas, S., Kirschner, V., Lester, C., Montague, C., Russell, S., Stockman, H., Taylor, B., Verdick, R., Walshire, J., Thompson, J. T., Connell, B., Constantine, M., Davis, J. L., Holsapple, G., Hunter, L., Lenane, C. N., Mitchell, R., Russel, L., Sjaarda, R., Brown, D. M., Benz, M., Burns, L., Carranza, J. G., Fish, R., Goates, D., Hay, S., Jeffers, T., Kegley, E., Kubecka, D., McGilvra, S., Richter, B., Sneed, V., Stoever, C., Tellez, I., Wong, T., Kim, I., Andreoli, C., Barresi, L., Brett, S., Callahan, C., Capaccioli, K., Carli, W., Coppola, M., Emmanuel, N., Evans, C., Fagan, A., Grillo, M., Head, J., Kieser, T., Lee, E., Lord, U., Miretsky, E., Palitsch, K., Petrin, T., Reader, L., Reznichenko, S., Robertson, M., Smith, J., Vavvas, D., Wells, J., Cahill, C., Lloyd Clark, W., Henry, K., Johnson, D., Miller, P., Oliver, L., Spivey, R., Swinford, T., Taylor, M., Lambert, M., Chase, K., Fredrickson, D., Khawly, J., Lazarte, V., Lowd, D., Miller, P., Willis, A., Ferrone, P. J., Almonte, M., Arnott, R., Aviles, I., Carbon, S., Chitjian, M., Damore, K., Elliott, C., Fastenberg, D., Golub, B., Graham, K., Lavorna, A., Murphy, L., Palomo, A., Puglisi, C., Rhee, D., Romero, J., Rosenblatt, B., Salcedo, G., Schlameuss, M., Shakin, E., Sookhai, V., Kaiser, R., Affel, E., Brown, G., Centinaro, C., Fine, D., Fineman, M., Formoso, M., Garg, S., Grande, L., Herbert, C., Ho, A., Hsu, J., Jay, M., Lavetsky, L., Liebenbaum, E., Maguire, J., Monsonego, J., O'Connor, L., Pierce, L., Regillo, C., Rosario, M., Spirn, M., Vander, J., Walsh, J., Davidorf, F. H., Barnett, A., Chang, S., Christoforidis, J., Elliott, J., Justice, H., Letson, A., McKinney, K., Perry, J., Salerno, J. A., Savage, S., Shelley, S., Singerman, L. J., Coney, J., Dubois, J., Dubois, K., Greanoff, G., Himmelman, D., Ilc, M., McNamara, E., Novak, M., Pendergast, S., Rath, S., Smith-Brewer, S., Tanner, V., Weiss, D. E., Zegarra, H., Halperin, L., Aramayo, P., Dhalla, M., Fernandez, B., Fernandez, C., Lopez, J., Lopez, M., Mariano, J., Murphy, K., Sherley, C., Veksler, R., Rahhal, F., Babikian, R., Boyer, D., Hami, S., Kessinger, J., Kurokouchi, J., Mukarram, S., Pachman, S., Protacio, E., Sierra, J., Tabandeh, H., Zamboni, A., Elman, M., Belz, J., Butcher, T., Cain, T., Coffey, T., Firestone, D., Gore, N., Singletary, P., Sotirakos, P., Starr, J., Meredith, T. A., Barnhart, C. J., Cantrell, D., Esquejo-Leon, R., Houghton, O., Kaur, H., Ndure, F., Glatzer, R., Joffe, L., Schindler, R., Fine, S. L., Katz, M., Brightwell-Arnold, M., Glaser, R., Hall, J., Harkins, S., Huang, J., Khvatov, A., McWilliams, K., Peskin, E., Pistilli, M., Ryan, S., Schnader, A., Afrani-Sakyi, J., Balsley, B., Bennett, L. S., Brooks, A., Brower-Lingsch, A., Bruce, L., Busian, D., Choong, J., Cloaninger, L., DeCroos, F. C., Dubois, E., El-Dairi, M., Gach, S., Hall, K., Hawks, T., Huang, C., Heydary, C., Ho, A., Kini, S., McCall, M., Muhammad, D., Nicholson, J., Rieves, P., Shields, K., Specker, A., Stinnett, S., Subramaniam, S., Tenbrink, P., Towe, A., Welch, K., Williams, N., Winter, K., Young, E., Alexander, J., Flannagan, E., Martin, E. R., Parker, C., Sepielli, K., Shannon, T., Whearry, C., Redford, M., Kopfer, M. R., Ferris, F. L., Dupont, J., Friedman, L. M., Bressler, S. B., Demets, D. L., Friedlander, M., Johnson, M. W., Lindblad, A., Losordo, D. W. & Miller, F. G., Sep 1 2015, In : Ophthalmology. 122, 9, p. 1846-1853 8 p.

Research output: Contribution to journalArticle

Macular Degeneration
Geographic Atrophy
Visual Acuity
Cicatrix
Optical Coherence Tomography
2014
51 Citations (Scopus)

No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38

Chew, E. Y., Klein, M., Clemons, T. E., Agrón, E., Ratnapriya, R., Edwards, A. O., Fritsche, L. G., Swaroop, A. & Abecasis, G. R., Nov 1 2014, In : Ophthalmology. 121, 11, p. 2173-2180 8 p.

Research output: Contribution to journalArticle

Complement Factor H
Eye Diseases
Macular Degeneration
Genotype
Macular Degeneration, Age-Related, 2
14 Citations (Scopus)

Prevalence of anti-retinal autoantibodies in different stages of Age-related macular degeneration

Adamus, G., Chew, E. Y., Ferris, F. L. & Klein, M., 2014, In : BMC Ophthalmology. 14, p. 154 1 p.

Research output: Contribution to journalArticle

Macular Degeneration
Autoantibodies
Geographic Atrophy
Eye Diseases
Phosphopyruvate Hydratase
411 Citations (Scopus)

Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration

Yali, J., Bailey, S., Wilson, D., Tan, O., Klein, M., Flaxel, C., Potsaid, B., Liu, J. J., Lu, C. D., Kraus, M. F., Fujimoto, J. G. & Huang, D., 2014, In : Ophthalmology. 121, 7, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Optical Coherence Tomography
Macular Degeneration
Angiography
Retina
24 Citations (Scopus)

Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration

Ratnapriya, R., Zhan, X., Fariss, R. N., Branham, K. E., Zipprer, D., Chakarova, C. F., Sergeev, Y. V., Campos, M. M., Othman, M., Friedman, J. S., Maminishkis, A., Waseem, N. H., Brooks, M., Rajasimha, H. K., Edwards, A. O., Lotery, A., Klein, B. E., Truitt, B. J., Li, B., Schaumberg, D. A. & 47 others, Morgan, D. J., Morrison, M. A., Souied, E., Tsironi, E. E., Grassmann, F., Fishman, G. A., Silvestri, G., Scholl, H. P. N., Kim, I. K., Ramke, J., Tuo, J., Merriam, J. E., Merriam, J. C., Park, K. H., Olson, L. M., Farrer, L. A., Johnson, M. P., Peachey, N. S., Lathrop, M., Baron, R. V., Igo, R. P., Klein, R., Hagstrom, S. A., Kamatani, Y., Martin, T., Jiang, Y., Conley, Y., Sahel, J. A., Zack, D. J., Chan, C. C., Pericak-Vance, M. A., Jacobson, S. G., Gorin, M. B., Klein, M., Allikmets, R., Iyengar, S. K., Weber, B. H., Haines, J. L., Léveillard, T., Deangelis, M. M., Stambolian, D., Weeks, D. E., Bhattacharya, S. S., Chew, E. Y., Heckenlively, J. R., Abecasis, G. R. & Swaroop, A., Nov 1 2014, In : Human Molecular Genetics. 23, 21, p. 5827-5837 11 p.

Research output: Contribution to journalArticle

Macular Degeneration
Extracellular Matrix
Genes
Elastin
Bruch Membrane
255 Citations (Scopus)

Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials

Grunwald, J. E., Daniel, E., Huang, J., Ying, G. S., Maguire, M. G., Toth, C. A., Jaffe, G. J., Fine, S. L., Blodi, B., Klein, M., Martin, A. A., Hagstrom, S. A. & Martin, D. F., Jan 2014, In : Ophthalmology. 121, 1, p. 150-161 12 p.

Research output: Contribution to journalArticle

Geographic Atrophy
Macular Degeneration
Confidence Intervals
Therapeutics
Optical Coherence Tomography
151 Citations (Scopus)

Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression AREDS2 report no. 3

Chew, E. Y., Clemons, T. E., SanGiovanni, J. P., Danis, R. P., Ferris, F. L., Elman, M. J., Antoszyk, A. N., Ruby, A. J., Orth, D., Bressler, S. B., Fish, G. E., Hubbard, G. B., Klein, M., Chandra, S. R., Blodi, B. A., Domalpally, A., Friberg, T., Wong, W. T., Rosenfeld, P. J., Agrón, E. & 3 others, Toth, C. A., Bernstein, P. S. & Sperduto, R. D., Feb 2014, In : JAMA Ophthalmology. 132, 2, p. 142-149 8 p.

Research output: Contribution to journalArticle

Lutein
Eye Diseases
Macular Degeneration
beta Carotene
Geographic Atrophy
2013
156 Citations (Scopus)

Baseline predictors for one-year visual outcomes with ranibizumab or bevacizumab for neovascular age-related macular degeneration

Ying, G. S., Huang, J., Maguire, M. G., Jaffe, G. J., Grunwald, J. E., Toth, C., Daniel, E., Klein, M., Pieramici, D., Wells, J. & Martin, D. F., Jan 2013, In : Ophthalmology. 120, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

Macular Degeneration
Visual Acuity
Geographic Atrophy
Ranibizumab
Bevacizumab
46 Citations (Scopus)

Genetic determinants of macular pigments in women the carotenoids in age-related eye disease study

Meyers, K. J., Johnson, E. J., Bernstein, P. S., Iyengar, S. K., Engelman, C. D., Karki, C. K., Liu, Z., Igo, R. P., Truitt, B., Klein, M., Snodderly, D. M., Blodi, B. A., Gehrs, K. M., Sarto, G. E., Wallace, R. B., Robinson, J., LeBlanc, E. S., Hageman, G., Tinker, L. & Mares, J. A., 2013, In : Investigative Ophthalmology and Visual Science. 54, 3, p. 2333-2345 13 p.

Research output: Contribution to journalArticle

Eye Diseases
Carotenoids
Single Nucleotide Polymorphism
Genes
Photometry
58 Citations (Scopus)

Genetic evidence for role of carotenoids in age-related macular degeneration in the carotenoids in age-related eye disease study (CAREDS)

Meyers, K. J., Mares, J. A., Igo, R. P., Truitt, B., Liu, Z., Millen, A. E., Klein, M., Johnson, E. J., Engelman, C. D., Karki, C. K., Blodi, B., Gehrs, K., Tinker, L., Wallace, R., Robinson, J., LeBlanc, E. S., Sarto, G., Bernstein, P. S., SanGiovanni, J. P. & Iyengar, S. K., Dec 17 2013, In : Investigative Ophthalmology and Visual Science. 55, 1, p. 587-599 13 p.

Research output: Contribution to journalArticle

Eye Diseases
Macular Degeneration
Carotenoids
Lutein
Genes
96 Citations (Scopus)

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

Zhan, X., Larson, D. E., Wang, C., Koboldt, D. C., Sergeev, Y. V., Fulton, R. S., Fulton, L. L., Fronick, C. C., Branham, K. E., Bragg-Gresham, J., Jun, G., Hu, Y., Kang, H. M., Liu, D., Othman, M., Brooks, M., Ratnapriya, R., Boleda, A., Grassmann, F., Von Strachwitz, C. & 40 others, Olson, L. M., Buitendijk, G. H. S., Hofman, A., Van Duijn, C. M., Cipriani, V., Moore, A. T., Shahid, H., Jiang, Y., Conley, Y. P., Morgan, D. J., Kim, I. K., Johnson, M. P., Cantsilieris, S., Richardson, A. J., Guymer, R. H., Luo, H., Ouyang, H., Licht, C., Pluthero, F. G., Zhang, M. M., Zhang, K., Baird, P. N., Blangero, J., Klein, M., Farrer, L. A., DeAngelis, M. M., Weeks, D. E., Gorin, M. B., Yates, J. R. W., Klaver, C. C. W., Pericak-Vance, M. A., Haines, J. L., Weber, B. H. F., Wilson, R. K., Heckenlively, J. R., Chew, E. Y., Stambolian, D., Mardis, E. R., Swaroop, A. & Abecasis, G. R., Nov 2013, In : Nature Genetics. 45, 11, p. 1375-1381 7 p.

Research output: Contribution to journalArticle

Complement C3
Macular Degeneration
Odds Ratio
Exome
Alternative Complement Pathway
71 Citations (Scopus)

Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4

Chew, E. Y., SanGiovanni, J. P., Ferris, F. L., Wong, W. T., Agron, E., Clemons, T. E., Sperduto, R., Danis, R., Chandra, S. R., Blodi, B. A., Domalpally, A., Elman, M. J., Antoszyk, A. N., Ruby, A. J., Orth, D., Bressler, S. B., Fish, G. E., Hubbard, G. B., Klein, M., Friberg, T. R. & 3 others, Rosenfeld, P. J., Toth, C. A. & Bernstein, P., Jul 2013, In : JAMA Ophthalmology. 131, 7, p. 843-850 8 p.

Research output: Contribution to journalArticle

Lutein
Eye Diseases
Cataract
Therapeutics
Macular Degeneration
530 Citations (Scopus)

Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial

Chew, E. Y., Clemons, T. E., SanGiovanni, J. P., Danis, R., Ferris, F. L., Elman, M., Antoszyk, A., Ruby, A., Orth, D., Bressler, S., Fish, G., Hubbard, B., Klein, M., Chandra, S., Blodi, B., Domalpally, A., Friberg, T., Wong, W., Rosenfeld, P., Agron, E. & 3 others, Toth, C., Bernstein, P. & Sperdut, R., May 15 2013, In : JAMA - Journal of the American Medical Association. 309, 19, p. 2005-2015 11 p.

Research output: Contribution to journalArticle

Lutein
Eye Diseases
Omega-3 Fatty Acids
Macular Degeneration
Eicosapentaenoic Acid
100 Citations (Scopus)

Pharmacogenetics for genes associated with age-related macular degeneration in the comparison of AMD treatments trials (CATT)

Hagstrom, S. A., Ying, G. S., Pauer, G. J. T., Sturgill-Short, G. M., Huang, J., Callanan, D. G., Kim, I. K., Klein, M., Maguire, M. G. & Martin, D. F., Mar 2013, In : Ophthalmology. 120, 3, p. 593-599 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Macular Degeneration
Visual Acuity
Single Nucleotide Polymorphism
Fluorescein Angiography
446 Citations (Scopus)

Seven new loci associated with age-related macular degeneration

Fritsche, L. G., Chen, W., Schu, M., Yaspan, B. L., Yu, Y., Thorleifsson, G., Zack, D. J., Arakawa, S., Cipriani, V., Ripke, S., Igo, R. P., Buitendijk, G. H. S., Sim, X., Weeks, D. E., Guymer, R. H., Merriam, J. E., Francis, P. J., Hannum, G., Agarwal, A., Armbrecht, A. M. & 136 others, Audo, I., Aung, T., Barile, G. R., Benchaboune, M., Bird, A. C., Bishop, P. N., Branham, K. E., Brooks, M., Brucker, A. J., Cade, W. H., Cain, M. S., Campochiaro, P. A., Chan, C. C., Cheng, C. Y., Chew, E. Y., Chin, K. A., Chowers, I., Clayton, D. G., Cojocaru, R., Conley, Y. P., Cornes, B. K., Daly, M. J., Dhillon, B., Edwards, A. O., Evangelou, E., Fagerness, J., Ferreyra, H. A., Friedman, J. S., Geirsdottir, A., George, R. J., Gieger, C., Gupta, N., Hagstrom, S. A., Harding, S. P., Haritoglou, C., Heckenlively, J. R., Holz, F. G., Hughes, G., Ioannidis, J. P. A., Ishibashi, T., Joseph, P., Jun, G., Kamatani, Y., Katsanis, N., N Keilhauer, C., Khan, J. C., Kim, I. K., Kiyohara, Y., Klein, B. E. K., Klein, R., Kovach, J. L., Kozak, I., Lee, C. J., Lee, K. E., Lichtner, P., Lotery, A. J., Meitinger, T., Mitchell, P., Mohand-Saïd, S., Moore, A. T., Morgan, D. J., Morrison, M. A., Myers, C. E., Naj, A. C., Nakamura, Y., Okada, Y., Orlin, A., Ortube, M. C., Othman, M. I., Pappas, C., Park, K. H., Pauer, G. J. T., Peachey, N. S., Poch, O., Priya, R. R., Reynolds, R., Richardson, A. J., Ripp, R., Rudolph, G., Ryu, E., Sahel, J. A., Schaumberg, D. A., Scholl, H. P. N., Schwartz, S. G., Scott, W. K., Shahid, H., Sigurdsson, H., Silvestri, G., Sivakumaran, T. A., Smith, R. T., Sobrin, L., Souied, E. H., Stambolian, D. E., Stefansson, H., Sturgill-Short, G. M., Takahashi, A., Tosakulwong, N., Truitt, B. J., Tsironi, E. E., Uitterlinden, A. G., Van Duijn, C. M., Vijaya, L., Vingerling, J. R., Vithana, E. N., Webster, A. R., Wichmann, H. E., Winkler, T. W., Wong, T. Y., Wright, A. F., Zelenika, D., Zhang, M., Zhao, L., Zhang, K., Klein, M., Hageman, G. S., Lathrop, G. M., Stefansson, K., Allikmets, R., Baird, P. N., Gorin, M. B., Wang, J. J., Klaver, C. C. W., Seddon, J. M., Pericak-Vance, M. A., Iyengar, S. K., Yates, J. R. W., Swaroop, A., Weber, B. H. F., Kubo, M., Deangelis, M. M., Léveillard, T., Thorsteinsdottir, U., Haines, J. L., Farrer, L. A., Heid, I. M. & Abecasis, G. R., Apr 2013, In : Nature Genetics. 45, 4, p. 433-439 7 p.

Research output: Contribution to journalArticle

Macular Degeneration
Genome-Wide Association Study
Blindness
Lipid Metabolism
Genes
47 Citations (Scopus)

Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations

Engelman, C. D., Meyers, K. J., Iyengar, S. K., Liu, Z., Karki, C. K., Igo, R. P., Truitt, B., Robinson, J., Sarto, G. E., Wallace, R., Blodi, B. A., Klein, M., Tinker, L., LeBlanc, E. S., Jackson, R. D., Song, Y., Manson, J. E., Mares, J. A. & Millen, A. E., Jan 2013, In : Journal of Nutrition. 143, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

Vitamin D
Single Nucleotide Polymorphism
Genes
Vitamin D Deficiency
Eye Diseases
2012
94 Citations (Scopus)

Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration

Wei, L., Liu, B., Tuo, J., Shen, D., Chen, P., Li, Z., Liu, X., Ni, J., Dagur, P., Sen, H. N., Jawad, S., Ling, D., Park, S., Chakrabarty, S., Meyerle, C., Agron, E., Ferris, F. L., Chew, E. Y., McCoy, J. P., Blum, E. & 6 others, Francis, P. J., Klein, M., Guymer, R. H., Baird, P. N., Chan, C. C. & Nussenblatt, R. B., Nov 29 2012, In : Cell Reports. 2, 5, p. 1151-1158 8 p.

Research output: Contribution to journalArticle

Macular Degeneration
Methylation
Biomarkers
Blood
Genes
1 Citation (Scopus)

The related transcriptional enhancer factor-1 Isoform, TEAD4216, can repress vascular endothelial growth factor expression in mammalian cells

Appukuttan, B., McFarland, T. J., Stempel, A., Kassem, J. B., Hartzell, M., Zhang, Y., Bond, D., West, K., Wilson, R., Stout, A., Pan, Y., Ilias, H., Robertson, K., Klein, M., Wilson, D., Smith, J. R. & Stout, J. T., Jun 22 2012, In : PLoS One. 7, 6, e31260.

Research output: Contribution to journalArticle

vascular endothelial growth factors
Vascular Endothelial Growth Factor A
Protein Isoforms
Cells
hypoxia
2011
35 Citations (Scopus)

A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration

Sivakumaran, T. A., Igo, R. P., Kidd, J. M., Itsara, A., Kopplin, L. J., Chen, W., Hagstrom, S. A., Peachey, N. S., Francis, P. J., Klein, M., Chew, E. Y., Ramprasad, V. L., Tay, W. T., Mitchell, P., Seielstad, M., Stambolian, D. E., Edwards, A. O., Lee, K. E., Leontiev, D. V., Jun, G. & 20 others, Wang, Y., Tian, L., Qiu, F., Henning, A. K., LaFramboise, T., Sen, P., Aarthi, M., George, R., Raman, R., Das, M. K., Vijaya, L., Kumaramanickavel, G., Wong, T. Y., Swaroop, A., Abecasis, G. R., Klein, R., Klein, B. E. K., Nickerson, D. A., Eichler, E. E. & Iyengar, S. K., Oct 12 2011, In : PLoS One. 6, 10, e25598.

Research output: Contribution to journalArticle

Macular Degeneration
Haplotypes
haplotypes
Complement Factor H
Polymorphism
25 Citations (Scopus)
Macular Degeneration
Membranes
Fluorescein Angiography
Fluorescein
Tertiary Care Centers
91 Citations (Scopus)

Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration

Liu, B., Wei, L., Meyerle, C., Tuo, J., Sen, H. N., Li, Z., Chakrabarty, S., Agron, E., Chan, C. C., Klein, M., Chew, E., Ferris, F. & Nussenblatt, R. B., Jul 15 2011, In : Journal of Translational Medicine. 9, 1, 111.

Research output: Contribution to journalArticle

T-cells
Interleukin-17
Macular Degeneration
T-Lymphocytes
Assays
72 Citations (Scopus)

Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies

Mckay, G. J., Patterson, C. C., Chakravarthy, U., Dasari, S., Klaver, C. C., Vingerling, J. R., Ho, L., de Jong, P. T. V. M., Fletcher, A. E., Young, I. S., Seland, J. H., Rahu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A. D., Sofat, R., Dean, M., Sawitzke, J. & 30 others, Seddon, J. M., Peter, I., Webster, A. R., Moore, A. T., Yates, J. R. W., Cipriani, V., Fritsche, L. G., Weber, B. H. F., Keilhauer, C. N., Lotery, A. J., Ennis, S., Klein, M., Francis, P. J., Stambolian, D., Orlin, A., Gorin, M. B., Weeks, D. E., Kuo, C. L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G. R., Wright, A. F., Hayward, C., Baird, P. N., Guymer, R. H., Attia, J., Thakkinstian, A. & Silvestri, G., Dec 2011, In : Human Mutation. 32, 12, p. 1407-1416 10 p.

Research output: Contribution to journalArticle

Macular Degeneration
Apolipoproteins E
Odds Ratio
Confidence Intervals
Smoking
83 Citations (Scopus)

Healthy lifestyles related to subsequent prevalence of age-related macular degeneration

Mares, J. A., Voland, R. P., Sondel, S. A., Millen, A. E., LaRowe, T., Moeller, S. M., Klein, M., Blodi, B. A., Chappell, R. J., Tinker, L., Ritenbaugh, C., Gehrs, K. M., Sarto, G. E., Johnson, E., Snodderly, D. M. & Wallace, R. B., Apr 2011, In : Archives of Ophthalmology. 129, 4, p. 470-480 11 p.

Research output: Contribution to journalArticle

Macular Degeneration
Smoking
Exercise
Women's Health
Observational Studies
41 Citations (Scopus)

Risk assessment model for development of advanced age-related macular degeneration

Klein, M., Francis, P. J., Ferris, F. L., Hamon, S. C. & Clemons, T. E., Dec 2011, In : Archives of Ophthalmology. 129, 12, p. 1543-1550 8 p.

Research output: Contribution to journalArticle

Macular Degeneration
Eye Diseases
Calibration
Geographic Atrophy
Demography
20 Citations (Scopus)

Update on the role of genetics in the onset of age-related macular degeneration

Francis, P. J. & Klein, M., 2011, In : Clinical Ophthalmology. 5, 1, p. 1127-1133 7 p.

Research output: Contribution to journalArticle

Macular Degeneration
Genes
Alternative Complement Pathway
Genome-Wide Association Study
Pharmacogenetics
47 Citations (Scopus)

Variations in apolipoprotein e frequency with age in a pooled analysis of a large group of older people

McKay, G. J., Silvestri, G., Chakravarthy, U., Dasari, S., Fritsche, L. G., Weber, B. H., Keilhauer, C. N., Klein, M., Francis, P. J., Klaver, C. C., Vingerling, J. R., Ho, L., De Jong, P. T. D. V., Dean, M., Sawitzke, J., Baird, P. N., Guymer, R. H., Stambolian, D., Orlin, A., Seddon, J. M. & 28 others, Peter, I., Wright, A. F., Hayward, C., Lotery, A. J., Ennis, S., Gorin, M. B., Weeks, D. E., Kuo, C. L., Hingorani, A. D., Sofat, R., Cipriani, V., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G. R., Yates, J. R., Webster, A. R., Moore, A. T., Seland, J. H., Rahu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Young, I. S., Fletcher, A. E. & Patterson, C. C., Jun 15 2011, In : American Journal of Epidemiology. 173, 12, p. 1357-1364 8 p.

Research output: Contribution to journalArticle

Apolipoproteins
Apolipoproteins E
Protein Isoforms
Macular Degeneration
Genes
79 Citations (Scopus)

Vitamin D status and early age-related macular degeneration in postmenopausal women

Millen, A. E., Voland, R., Sondel, S. A., Parekh, N., Horst, R. L., Wallace, R. B., Hageman, G. S., Chappell, R., Blodi, B. A., Klein, M., Gehrs, K. M., Sarto, G. E. & Mares, J. A., Apr 2011, In : Archives of Ophthalmology. 129, 4, p. 481-489 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Vitamin D
Odds Ratio
Confidence Intervals
Serum
2010
360 Citations (Scopus)

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

Chen, W., Stambolian, D., Edwards, A. O., Branham, K. E., Othman, M., Jakobsdottir, J., Tosakulwong, N., Pericak-Vance, M. A., Campochiaro, P. A., Klein, M., Tan, P. L., Conley, Y. P., Kanda, A., Kopplin, L., Li, Y., Augustaitis, K. J., Karoukis, A. J., Scott, W. K., Agarwal, A., Kovach, J. L. & 46 others, Schwartz, S. G., Postel, E. A., Brooks, M., Baratz, K. H., Brown, W. L., Brucker, A. J., Orlin, A., Brown, G., Ho, A., Regillo, C., Donoso, L., Tian, L., Kaderli, B., Hadley, D., Hagstrom, S. A., Peachey, N. S., Klein, R., Klein, B. E. K., Gotoh, N., Yamashiro, K., Ferris, F., Fagerness, J. A., Reynolds, R., Farrer, L. A., Kim, I. K., Miller, J. W., Cortón, M., Carracedo, A., Sanchez-Salorio, M., Pugh, E. W., Doheny, K. F., Brion, M., DeAngelis, M. M., Weeks, D. E., Zack, D. J., Chew, E. Y., Heckenlively, J. R., Yoshimura, N., Iyengar, S. K., Francis, P. J., Katsanis, N., Seddon, J. M., Haines, J. L., Gorin, M. B., Abecasis, G. R. & Swaroop, A., Apr 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 16, p. 7401-7406 6 p.

Research output: Contribution to journalArticle

Macular Degeneration
HDL Lipoproteins
Genome-Wide Association Study
HDL Cholesterol
Alleles
44 Citations (Scopus)

Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration

Kopplin, L. J., Igo, R. P., Wang, Y., Sivakumaran, T. A., Hagstrom, S. A., Peachey, N. S., Francis, P. J., Klein, M., Sangiovanni, J. P., Chew, E. Y., Pauer, G. J. T., Sturgill, G. M., Joshi, T., Tian, L., Xi, Q., Henning, A. K., Lee, K. E., Klein, R., Klein, B. E. K. & Iyengar, S. K., Dec 2010, In : Genes and Immunity. 11, 8, p. 609-621 13 p.

Research output: Contribution to journalArticle

Macular Degeneration
Genome
Complement Factor H
Haplotypes
Complement C2
69 Citations (Scopus)

Natural History of Drusenoid Pigment Epithelial Detachment in Age-Related Macular Degeneration: Age-Related Eye Disease Study Report No. 28

Cukras, C., Agrón, E., Klein, M., Ferris, F. L., Chew, E. Y., Gensler, G. & Wong, W. T., Mar 2010, In : Ophthalmology. 117, 3, p. 489-499 11 p.

Research output: Contribution to journalArticle

Eye Diseases
Macular Degeneration
Natural History
Geographic Atrophy
Visual Acuity
46 Citations (Scopus)

Progression of geographic atrophy and genotype in age-related macular degeneration

Klein, M., Ferris, F. L., Francis, P. J., Lindblad, A. S., Chew, E. Y., Hamon, S. C. & Ott, J., 2010, In : Ophthalmology. 117, 8

Research output: Contribution to journalArticle

Geographic Atrophy
Macular Degeneration
Genotype
Growth
Eye Diseases
2009
111 Citations (Scopus)

Change in area of geographic atrophy in the age-related eye disease study: AREDS report number 26

Lindblad, A. S., Lloyd, P. C., Clemons, T. E., Gensler, G. R., Ferris, F. L., Klein, M. & Armstrong, J. R., Sep 2009, In : Archives of Ophthalmology. 127, 9, p. 1168-1174 7 p.

Research output: Contribution to journalArticle

Geographic Atrophy
Eye Diseases
Macular Degeneration
Growth