Michael Forte

Professor

  • 9980 Citations
  • 53 h-Index
1976 …2020

Research output per year

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Research Output

2020

A novel class of cardioprotective small-molecule PTP inhibitors

Antonucci, S., Di Sante, M., Sileikyte, J., Deveraux, J., Bauer, T., Bround, M. J., Menabò, R., Paillard, M., Alanova, P., Carraro, M., Ovize, M., Molkentin, J. D., Cohen, M., Forte, M. A., Bernardi, P., Di Lisa, F. & Murphy, E., Jan 2020, In : Pharmacological Research. 151, 104548.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease

Murphy, E., Bernardi, P., Cohen, M., Di Lisa, F., Forte, M., Molkentin, J. D. & Ovize, M., Apr 26 2019, In : Circulation research. 124, 9, p. 1294-1296 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

The mitochondrial permeability transition in mitochondrial disorders

Šileikytė, J. & Forte, M., 2019, In : Oxidative medicine and cellular longevity. 2019, 3403075.

Research output: Contribution to journalReview article

Open Access
11 Scopus citations
2018

The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH

Antoniel, M., Jones, K., Antonucci, S., Spolaore, B., Fogolari, F., Petronilli, V., Giorgio, V., Carraro, M., Di Lisa, F., Forte, M., Szabó, I., Lippe, G. & Bernardi, P., Feb 1 2018, In : EMBO Reports. 19, 2, p. 257-268 12 p.

Research output: Contribution to journalArticle

39 Scopus citations
2017

Ca2+ binding to F-ATP synthase β subunit triggers the mitochondrial permeability transition

Giorgio, V., Burchell, V., Schiavone, M., Bassot, C., Minervini, G., Petronilli, V., Argenton, F., Forte, M., Tosatto, S., Lippe, G. & Bernardi, P., Jul 1 2017, In : EMBO Reports. 18, 7, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

79 Scopus citations
2016

Commentary: The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria

Bernardi, P. & Forte, M., Nov 25 2016, In : Frontiers in Physiology. 7, NOV, 583.

Research output: Contribution to journalComment/debate

2 Scopus citations

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Roy, S., Šileikyte, J., Neuenswander, B., Hedrick, M. P., Chung, T. D. Y., Aubé, J., Schoenen, F. J., Forte, M. A. & Bernardi, P., Feb 4 2016, In : ChemMedChem. 11, 3, p. 283-288 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
16 Scopus citations
2015

Commentary: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore

Bernardi, P. & Forte, M., 2015, In : Frontiers in Physiology. 6, NOV, 320.

Research output: Contribution to journalComment/debate

18 Scopus citations

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Roy, S., Šileikyte, J., Schiavone, M., Neuenswander, B., Argenton, F., Aubé, J., Hedrick, M. P., Chung, T. D. Y., Forte, M. A., Bernardi, P. & Schoenen, F. J., Oct 1 2015, In : ChemMedChem. 10, 10, p. 1655-1671 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release

Von Stockum, S., Giorgio, V., Trevisan, E., Lippe, G., Glick, G. D., Forte, M. A., Da-Rè, C., Checchetto, V., Mazzotta, G., Costa, R., Szabò, I. & Bernardi, P., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4537-4544 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

The mitochondrial permeability transition pore: Channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology

Bernardi, P., Rasola, A., Forte, M. & Lippe, G., Oct 1 2015, In : Physiological Reviews. 95, 4, p. 1111-1155 45 p.

Research output: Contribution to journalArticle

270 Scopus citations
2014

Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transition

Carraro, M., Giorgio, V., Sileikyte, J., Sartori, G., Forte, M., Lippe, G., Zoratti, M., Szabò, I. & Bernardi, P., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 15980-15985 6 p.

Research output: Contribution to journalArticle

Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transition

Carraro, M., Giorgio, V., Sileikyte, J., Sartori, G., Forte, M., Lippe, G., Zoratti, M., Szabò, I. & Bernardi, P., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 15980-15985 6 p.

Research output: Contribution to journalArticle

93 Scopus citations

Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (translocator protein of 18 kDa (TSPO))

Šileikyte, J., Blachly-Dyson, E., Sewell, R., Carpi, A., Menabò, R., Di Lisa, F., Ricchelli, F., Bernardi, P. & Forte, M., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 13769-13781 13 p.

Research output: Contribution to journalArticle

115 Scopus citations
2013

BH3-only proteins Noxa, Bik, Bmf, and Bid activate Bax and Bak indirectly when studied in yeast model

Gérecová, G., Kopanicová, J., Jaká, P., Běhalová, L., Juhásová, B., Bhatia-Kiššová, I., Forte, M., Polčic, P. & Mentel, M., Dec 1 2013, In : FEMS Yeast Research. 13, 8, p. 747-754 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Dimers of mitochondrial ATP synthase form the permeability transition pore

Giorgio, V., Von Stockum, S., Antoniel, M., Fabbro, A., Fogolari, F., Forte, M., Glick, G. D., Petronilli, V., Zoratti, M., Szabó, I., Lippe, G. & Bernardi, P., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 5887-5892 6 p.

Research output: Contribution to journalArticle

559 Scopus citations

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

Su, K., Bourdette, D. & Forte, M., 2013, In : Frontiers in Physiology. 4 JUL, Article 169.

Research output: Contribution to journalReview article

44 Scopus citations
2012
11 Scopus citations
14 Scopus citations

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis

Su, K. G., Savino, C., Marracci, G., Chaudhary, P., Yu, X., Morris, B., Galipeau, D., Giorgio, M., Forte, M. & Bourdette, D., Feb 1 2012, In : European Journal of Neuroscience. 35, 3-4, p. 562-571 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons

Barsukova, A., Komarov, A., Hajnóczky, G., Bernardi, P., Bourdette, D. & Forte, M., Mar 1 2011, In : European Journal of Neuroscience. 33, 5, p. 831-842 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast

Juhásová, B., Mentel, M., Bhatia-Kiššová, I., Zeman, I., Kolarov, J., Forte, M. & Polčic, P., Sep 2 2011, In : FEBS Letters. 585, 17, p. 2709-2713 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress

Barsukova, A. G., Bourdette, D. & Forte, M., Aug 1 2011, In : European Journal of Neuroscience. 34, 3, p. 437-447 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Properties of Ca 2+ transport in mitochondria of Drosophila melanogaster

Von Stockum, S., Basso, E., Petronilli, V., Sabatelli, P., Forte, M. A. & Bernardi, P., Dec 2 2011, In : Journal of Biological Chemistry. 286, 48, p. 41163-41170 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Reconstitution of interactions of Murine gammaherpesvirus 68 M11 with Bcl-2 family proteins in yeast

Juhásová, B., Bhatia-Kiššová, I., Polčicová, K., Mentel, M., Forte, M. & Polčic, P., Apr 22 2011, In : Biochemical and Biophysical Research Communications. 407, 4, p. 783-787 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2010

Cyclophilin D in mitochondrial pathophysiology

Giorgio, V., Soriano, M. E., Basso, E., Bisetto, E., Lippe, G., Forte, M. A. & Bernardi, P., Jun 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 6-7, p. 1113-1118 6 p.

Research output: Contribution to journalReview article

113 Scopus citations

The mitochondrial permeability transition from yeast to mammals

Azzolin, L., von Stockum, S., Basso, E., Petronilli, V., Forte, M. A. & Bernardi, P., Jun 1 2010, In : FEBS Letters. 584, 12, p. 2504-2509 6 p.

Research output: Contribution to journalReview article

91 Scopus citations
2009

Axonal degeneration in multiple sclerosis: The mitochondrial hypothesis

Su, K. G., Banker, G., Bourdette, D. & Forte, M., Aug 17 2009, In : Current neurology and neuroscience reports. 9, 5, p. 411-417 7 p.

Research output: Contribution to journalReview article

106 Scopus citations

Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex

Giorgio, V., Bisetto, E., Soriano, M. E., Dabbeni-Sala, F., Basso, E., Petronilli, V., Forte, M. A., Bernardi, P. & Lippe, G., Dec 4 2009, In : Journal of Biological Chemistry. 284, 49, p. 33982-33988 7 p.

Research output: Contribution to journalArticle

189 Scopus citations

Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury

Wang, X., Carlsson, Y., Basso, E., Zhu, C., Rousset, C. I., Rasola, A., Johansson, B. R., Blomgren, K., Mallard, C., Bernardi, P., Forte, M. A. & Hagberg, H., Feb 25 2009, In : Journal of Neuroscience. 29, 8, p. 2588-2596 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

Palma, E., Tiepolo, T., Angelin, A., Sabatelli, P., Maraldi, N. M., Basso, E., Forte, M. A., Bernardip, P. & Bonaldo, P., May 19 2009, In : Human molecular genetics. 18, 11, p. 2024-2031 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

Sano, R., Annunziata, I., Patterson, A., Moshiach, S., Gomero, E., Opferman, J., Forte, M. & d'Azzo, A., Nov 13 2009, In : Molecular Cell. 36, 3, p. 500-511 12 p.

Research output: Contribution to journalArticle

162 Scopus citations
2008

Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D

Luvisetto, S., Basso, E., Petronilli, V., Bernardi, P. & Forte, M., Aug 26 2008, In : Neuroscience. 155, 3, p. 585-596 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

Chiara, F., Castellaro, D., Marin, O., Petronilli, V., Brusilow, W. S., Juhaszova, M., Sollott, S. J., Forte, M., Bernardi, P. & Rasola, A., Mar 19 2008, In : PloS one. 3, 3, e1852.

Research output: Contribution to journalArticle

184 Scopus citations

Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation

Basso, E., Petronilli, V., Forte, M. A. & Bernardi, P., Sep 26 2008, In : Journal of Biological Chemistry. 283, 39, p. 26307-26311 5 p.

Research output: Contribution to journalArticle

126 Scopus citations

The Mitochondrial Permeability Transition Pore

Bernardi, P. & Forte, M., May 20 2008, Mitochondrial Biology: New Perspectives. wiley, p. 157-164 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2007

Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

Forte, M., Gold, B. G., Marracci, G., Chaudhary, P., Basso, E., Johnsen, D., Yu, X., Fowlkes, J., Bernardi, P. & Bourdette, D., May 1 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7558-7563 6 p.

Research output: Contribution to journalArticle

152 Scopus citations

Role of cyclophilin D in hypoxia-ischemia induced brain injury during development

Wang, X., Forte, M. A., Bernardi, P., Rousset, C., Zhu, C., Blomgren, K., Carlsson, Y., Mallard, C. & Hagberg, H., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BO08-03

Research output: Contribution to journalArticle

The mitochondrial permeability transition pore

Bernardi, P. & Forte, M., Dec 1 2007, Mitochondrial Biology: New Perspectives. p. 157-164 8 p. (Novartis Foundation Symposium; vol. 287).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

73 Scopus citations
2006

Erratum: The mitochondrial permeability transition from in vitro artifact to disease target (FEBS Journal (2006) 273 (2077-2099))

Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blachly-Dyson, E., Di Lisa, F. & Forte, M. A., Jun 1 2006, In : FEBS Journal. 273, 11, 1 p.

Research output: Contribution to journalComment/debate

Gsalpha is involved in sugar perception in Drosophila melanogaster.

Ueno, K., Kohatsu, S., Clay, C., Forte, M., Isono, K. & Kidokoro, Y., Jun 7 2006, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 26, 23, p. 6143-6152 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Properties of the permeability transition in VDAC1-/- mitochondria

Krauskopf, A., Eriksson, O., Craigen, W. J., Forte, M. A. & Bernardi, P., May 1 2006, In : Biochimica et Biophysica Acta - Bioenergetics. 1757, 5-6, p. 590-595 6 p.

Research output: Contribution to journalArticle

171 Scopus citations

The mitochondrial permeability transition from in vitro artifact to disease target

Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy-Dyson, E., Di Lisa, F. & Forte, M. A., May 1 2006, In : FEBS Journal. 273, 10, p. 2077-2099 23 p.

Research output: Contribution to journalReview article

498 Scopus citations

The permeability transition and BCL-2 family proteins in apoptosis: Co-conspirators or independent agents?

Forte, M. & Bernardi, P., Aug 1 2006, In : Cell Death and Differentiation. 13, 8, p. 1287-1290 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
2005

Cardiolipin and phosphatidylglycerol are not required for the in vivo action of Bcl-2 family proteins [3]

Polĉic, P., Su, X., Fowlkes, J., Blachly-Dyson, E., Dowhan, W. & Forte, M., Mar 1 2005, In : Cell Death and Differentiation. 12, 3, p. 310-312 3 p.

Research output: Contribution to journalLetter

20 Scopus citations

Genetic dissection of the permeability transition pore

Forte, M. & Bernardi, P., Jun 1 2005, In : Journal of Bioenergetics and Biomembranes. 37, 3, p. 121-128 8 p.

Research output: Contribution to journalReview article

67 Scopus citations

Properties of the permeability transition pore in mitochondria devoid of cyclophilin D

Basso, E., Fante, L., Fowlkes, J., Petronilli, V., Forte, M. A. & Bernardi, P., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 18558-18561 4 p.

Research output: Contribution to journalArticle

617 Scopus citations