Michael Chapman

Professor

  • 4338 Citations
  • 36 h-Index
1983 …2019

Research output per year

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Research Output

2019

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, aavr

Meyer, N. L., Hu, G., Davulcu, O., Xie, Q., Noble, A. J., Yoshioka, C., Gingerich, D. S., Trzynka, A., David, L., Stagg, S. M. & Chapman, M. S., May 2019, In : eLife. 8, e44707.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. & Nakai, H., 2017, In : Journal of Virology. 91, 3, e01980-16.

Research output: Contribution to journalArticle

31 Scopus citations

Adenoassociated virus (AAV) serotypes have distinctive interactions with domains of the cellular AAV receptor

Pillay, S., Zou, W., Cheng, F., Puschnik, A. S., Meyer, N. L., Ganaie, S. S., Deng, X., Wosen, J. E., Davulcu, O., Yan, Z., Engelhardt, J. F., Brown, K. E., Chapman, M. S., Qiu, J. & Carette, J. E., Sep 1 2017, In : Journal of virology. 91, 18, e00391-17.

Research output: Contribution to journalArticle

39 Scopus citations

Elevated μs-ms timescale backbone dynamics in the transition state analog form of arginine kinase

Davulcu, O., Peng, Y., Brüschweiler, R., Skalicky, J. J. & Chapman, M., Apr 11 2017, (Accepted/In press) In : Journal of Structural Biology.

Research output: Contribution to journalArticle

1 Scopus citations

The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide

Xie, Q., Spear, J. M., Noble, A. J., Sousa, D. R., Meyer, N. L., Davulcu, O., Zhang, F., Linhardt, R. J., Stagg, S. M. & Chapman, M., Jun 16 2017, In : Molecular Therapy - Methods and Clinical Development. 5, p. 1-12 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

The Michaelis Complex of Arginine Kinase Samples the Transition State at a Frequency That Matches the Catalytic Rate

Peng, Y., Hansen, A. L., Bruschweiler-Li, L., Davulcu, O., Skalicky, J. J., Chapman, M. & Brüschweiler, R., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4846-4853 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

An essential receptor for adeno-associated virus infection

Pillay, S., Meyer, N. L., Puschnik, A. S., Davulcu, O., Diep, J., Ishikawa, Y., Jae, L. T., Wosen, J. E., Nagamine, C. M., Chapman, M. & Carette, J. E., Feb 4 2016, In : Nature. 530, 7588, p. 108-112 5 p.

Research output: Contribution to journalArticle

144 Scopus citations

The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase

Godsey, M. H., Davulcu, O., Nix, J. C., Skalicky, J. J., Brüschweiler, R. P. & Chapman, M. S., Oct 4 2016, In : Structure. 24, 10, p. 1658-1667 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Parsimony in Protein Conformational Change

Chapman, B. K., Davulcu, O., Skalicky, J. J., Brüschweiler, R. P. & Chapman, M. S., Jul 9 2015, In : Structure. 23, 7, p. 1190-1198 9 p., 3194.

Research output: Contribution to journalArticle

5 Scopus citations

The influence of frame alignment with dose compensation on the quality of single particle reconstructions

Spear, J. M., Noble, A. J., Xie, Q., Sousa, D. R., Chapman, M. S. & Stagg, S. M., Nov 2015, In : Journal of Structural Biology. 192, 2, p. 196-203 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Backbone resonance assignments of the 42 kDa enzyme arginine kinase in the transition state analogue form

Davulcu, O., Niu, X., Brüschweiler-Li, L., Brüschweiler, R., Skalicky, J. J. & Chapman, M. S., Oct 1 2014, In : Biomolecular NMR Assignments. 8, 2, p. 335-338 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Common hydrogen bond interactions in diverse phosphoryl transfer active sites

Summerton, J. C., Martin, G. M., Evanseck, J. D. & Chapman, M. S., Sep 19 2014, In : PloS one. 9, 9, e108310.

Research output: Contribution to journalArticle

1 Scopus citations

ResLog plots: A new metric for the quality of cryo-EM reconstructions

Stagg, S. M., Noble, A. J., Spilman, M. & Chapman, M., Aug 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 1254-1255 2 p.

Research output: Contribution to journalConference article

ResLog plots as an empirical metric of the quality of cryo-EM reconstructions

Stagg, S. M., Noble, A. J., Spilman, M. & Chapman, M. S., Mar 1 2014, In : Journal of Structural Biology. 185, 3, p. 418-426 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs

Boudko, S. P., Ishikawa, Y., Nix, J., Chapman, M. S. & Bächinger, H. P., Jan 2014, In : Protein Science. 23, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Atomic modeling of cryo-electron microscopy reconstructions - Joint refinement of model and imaging parameters

Chapman, M. S., Trzynka, A. & Chapman, B. K., Apr 1 2013, In : Journal of Structural Biology. 182, 1, p. 10-21 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of interactions between heparin/glycosaminoglycan and adeno-associated virus

Zhang, F., Aguilera, J., Beaudet, J. M., Xie, Q., Lerch, T. F., Davulcu, O., Colón, W., Chapman, M. S. & Linhardt, R. J., Sep 10 2013, In : Biochemistry. 52, 36, p. 6275-6285 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Electron microscopy analysis of a disaccharide analog complex reveals receptor interactions of adeno-associated virus

Xie, Q., Spilman, M., Meyer, N. L., Lerch, T. F., Stagg, S. M. & Chapman, M. S., Nov 1 2013, In : Journal of Structural Biology. 184, 2, p. 129-135 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Crystal structures of arginine kinase in complex with ADP, nitrate, and various phosphagen analogs

Clark, S. A., Davulcu, O. & Chapman, M. S., Oct 12 2012, In : Biochemical and Biophysical Research Communications. 427, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse

Boudko, S. P., Ishikawa, Y., Lerch, T. F., Nix, J., Chapman, M. S. & Bächinger, H. P., Nov 12 2012, In : BMC Research Notes. 5, 626.

Research output: Contribution to journalArticle

7 Scopus citations

Hyperconjugation-mediated solvent effects in phosphoanhydride bonds

Summerton, J. C., Evanseck, J. D. & Chapman, M., Oct 18 2012, In : Journal of Physical Chemistry A. 116, 41, p. 10209-10217 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of the heparin binding site on adeno-associated virus serotype 3B (AAV-3B)

Lerch, T. F. & Chapman, M. S., Feb 5 2012, In : Virology. 423, 1, p. 6-13 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structure of AAV-DJ, a retargeted gene therapy vector: Cryo-electron microscopy at 4.5 Å resolution

Lerch, T. F., O'Donnell, J. K., Meyer, N. L., Xie, Q., Taylor, K. A., Stagg, S. M. & Chapman, M. S., Aug 8 2012, In : Structure. 20, 8, p. 1310-1320 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20

McCraw, D. M., O'Donnell, J. K., Taylor, K. A., Stagg, S. M. & Chapman, M. S., Sep 15 2012, In : Virology. 431, 1-2, p. 40-49 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2011

Arginine kinase: Joint crystallographic and NMR RDC analyses link substrate-associated motions to intrinsic flexibility

Niu, X., Bruschweiler-Li, L., Davulcu, O., Skalicky, J. J., Brüschweiler, R. & Chapman, M. S., Jan 14 2011, In : Journal of molecular biology. 405, 2, p. 479-496 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

Crystal structure of the human collagen XV trimerization domain: A potent trimerizing unit common to multiplexin collagens

Wirz, J. A., Boudko, S. P., Lerch, T. F., Chapman, M. S. & Bächinger, H. P., Jan 1 2011, In : Matrix Biology. 30, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rate-limiting domain and loop motions in arginine kinase

Davulcu, O., Skalicky, J. J. & Chapman, M. S., May 17 2011, In : Biochemistry. 50, 19, p. 4011-4018 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (AAV-6)

Xie, Q., Lerch, T. F., Meyer, N. L. & Chapman, M. S., Nov 10 2011, In : Virology. 420, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Subunit dissociation and metal binding by Escherichia coli apo-manganese superoxide dismutase

Whittaker, M. M., Lerch, T. F., Kirillova, O., Chapman, M. S. & Whittaker, J. W., Jan 15 2011, In : Archives of Biochemistry and Biophysics. 505, 2, p. 213-225 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

The structure of lombricine kinase: Implications for phosphagen kinase conformational changes

Bush, D. J., Kirillova, O., Clark, S. A., Davulcu, O., Fabiola, F., Xie, Q., Somasundaram, T., Ellington, W. R. & Chapman, M. S., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9338-9350 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

A pseudo-plaque method for infectious particle assay and clonal isolation of adeno-associated virus

Mitchell, D. A. J., Lerch, T. F., Hare, J. T. & Chapman, M. S., Dec 1 2010, In : Journal of Virological Methods. 170, 1-2, p. 9-15 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

De-icing: Recovery of diffraction intensities in the presence of ice rings

Chapman, M. S. & Somasundaram, T., May 15 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 6, p. 741-744 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion

Lerch, T. F., Xie, Q. & Chapman, M. S., Jul 1 2010, In : Virology. 403, 1, p. 26-36 11 p.

Research output: Contribution to journalArticle

58 Scopus citations
2009

Adeno-associated virus-2 and its primary cellular receptor-Cryo-EM structure of a heparin complex

O'Donnell, J., Taylor, K. A. & Chapman, M. S., Mar 15 2009, In : Virology. 385, 2, p. 434-443 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Crystal Structure of Human Collagen XVIII Trimerization Domain: A Novel Collagen Trimerization Fold

Boudko, S. P., Sasaki, T., Engel, J., Lerch, T. F., Nix, J., Chapman, M. S. & Bächinger, H. P., Sep 25 2009, In : Journal of molecular biology. 392, 3, p. 787-802 16 p.

Research output: Contribution to journalArticle

25 Scopus citations

Intrinsic Domain and Loop Dynamics Commensurate with Catalytic Turnover in an Induced-Fit Enzyme

Davulcu, O., Flynn, P. F., Chapman, M. S. & Skalicky, J. J., Oct 14 2009, In : Structure. 17, 10, p. 1356-1367 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Twinned crystals of adeno-associated virus serotype 3b prove suitable for structural studies

Lerch, T. F., Xie, Q., Ongley, H. M., Hare, J. & Chapman, M. S., Feb 13 2009, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2008

Anomeric effect in "high energy" phosphate bonds. Selective destabilization of the scissile bond and modulation of the exothermicity of hydrolysis

Ruben, E. A., Plumley, J. A., Chapman, M. & Evanseck, J. D., Mar 19 2008, In : Journal of the American Chemical Society. 130, 11, p. 3349-3358 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 6

Xie, Q., Ongley, H. M., Hare, J. & Chapman, M. S., Nov 18 2008, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 64, 11, p. 1074-1078 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2007

Hydrogen bonding mediated by key orbital interactions determines hydration enthalpy differences of phosphate water clusters

Ruben, E. A., Chapman, M. S. & Evanseck, J. D., Oct 25 2007, In : Journal of Physical Chemistry A. 111, 42, p. 10804-10814 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Normalizing Normal Mode Analysis

Chapman, M. S., Feb 1 2007, In : Structure. 15, 2, p. 135-136 2 p.

Research output: Contribution to journalShort survey

2006

Bias in cross-validated free R factors: Mitigation of the effects of non-crystallographic symmetry

Fabiola, F., Korostelev, A. & Chapman, M. S., Mar 1 2006, In : Acta Crystallographica Section D: Biological Crystallography. 62, 3, p. 227-238 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Characterization of the capsid protein glycosylation of adeno-associated virus type 2 by high-resolution mass spectrometry

Murray, S., Nilsson, C. L., Hare, J. T., Emmett, M. R., Korostelev, A., Ongley, H., Marshall, A. G. & Chapman, M. S., Jun 2006, In : Journal of virology. 80, 12, p. 6171-6176 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Elongation Arrest by SecM via a Cascade of Ribosomal RNA Rearrangements

Mitra, K., Schaffitzel, C., Fabiola, F., Chapman, M. S., Ban, N. & Frank, J., May 19 2006, In : Molecular Cell. 22, 4, p. 533-543 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Intensity and mosaic spread analysis from PISEMA tensors in solid-state NMR

Quine, J. R., Achuthan, S., Asbury, T., Bertram, R., Chapman, M. S., Hu, J. & Cross, T. A., Apr 1 2006, In : Journal of Magnetic Resonance. 179, 2, p. 190-198 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

pipath: An optimized algorithm for generating α-helical structures from PISEMA data

Asbury, T., Quine, J. R., Achuthan, S., Hu, J., Chapman, M. S., Cross, T. A. & Bertram, R., Nov 1 2006, In : Journal of Magnetic Resonance. 183, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Serotype-specific detection of adeno-associated virus during laboratory preparation

Mitchell, D. A. J., O'Donnell, J., Hare, J. T. & Chapman, M. S., Sep 1 2006, In : Journal of Virological Methods. 136, 1-2, p. 277-282 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2005

Fitting of high-resolution structures into electron microscopy reconstruction images

Fabiola, F. & Chapman, M. S., Mar 2005, In : Structure. 13, 3, p. 389-400 12 p.

Research output: Contribution to journalArticle

94 Scopus citations
13 Scopus citations

Main chain 1H, 13C, and 15N resonance assignments of the 42-kDa enzyme arginine kinase [7]

Davulcu, O., Clark, S. A., Chapman, M. S. & Skalicky, J. J., Jun 1 2005, In : Journal of Biomolecular NMR. 32, 2, 1 p.

Research output: Contribution to journalLetter

8 Scopus citations