Michael Chapman

Professor

  • 4192 Citations
  • 35 h-Index
1983 …2019
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Research Output 1986 2019

  • 4192 Citations
  • 35 h-Index
  • 102 Article
2019
3 Citations (Scopus)

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

Meyer, N. L., Hu, G., Davulcu, O., Xie, Q., Noble, A. J., Yoshioka, C., Gingerich, D. S., Trzynka, A., David, L., Stagg, S. M. & Chapman, M., May 22 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Gene therapy
Dependovirus
Viruses
Genetic Therapy
Electron Microscope Tomography
2017
25 Citations (Scopus)

Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. & Nakai, H., 2017, In : Journal of Virology. 91, 3, e01980-16.

Research output: Contribution to journalArticle

Dependovirus
Virus Assembly
capsid
Capsid
serotypes
29 Citations (Scopus)

Adenoassociated virus (AAV) serotypes have distinctive interactions with domains of the cellular AAV receptor

Pillay, S., Zou, W., Cheng, F., Puschnik, A. S., Meyer, N. L., Ganaie, S. S., Deng, X., Wosen, J. E., Davulcu, O., Yan, Z., Engelhardt, J. F., Brown, K. E., Chapman, M., Qiu, J. & Carette, J. E., Sep 1 2017, In : Journal of Virology. 91, 18, e00391-17.

Research output: Contribution to journalArticle

Dependovirus
Virus Receptors
serotypes
Viruses
viruses
1 Citation (Scopus)

Elevated μs-ms timescale backbone dynamics in the transition state analog form of arginine kinase

Davulcu, O., Peng, Y., Brüschweiler, R., Skalicky, J. J. & Chapman, M., Apr 11 2017, (Accepted/In press) In : Journal of Structural Biology.

Research output: Contribution to journalArticle

Arginine Kinase
Enzymes
Magnetic Resonance Spectroscopy
Catalysis
Arginine
9 Citations (Scopus)

The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide

Xie, Q., Spear, J. M., Noble, A. J., Sousa, D. R., Meyer, N. L., Davulcu, O., Zhang, F., Linhardt, R. J., Stagg, S. M. & Chapman, M., Jun 16 2017, In : Molecular Therapy - Methods and Clinical Development. 5, p. 1-12 12 p.

Research output: Contribution to journalArticle

Heparinoids
Dependovirus
Electron Microscopy
Polysaccharides
Heparin
4 Citations (Scopus)

The Michaelis Complex of Arginine Kinase Samples the Transition State at a Frequency That Matches the Catalytic Rate

Peng, Y., Hansen, A. L., Bruschweiler-Li, L., Davulcu, O., Skalicky, J. J., Chapman, M. & Brüschweiler, R., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4846-4853 8 p.

Research output: Contribution to journalArticle

Arginine Kinase
Arginine
Substrates
Adenosine Diphosphate
Chemical shift
2016
119 Citations (Scopus)

An essential receptor for adeno-associated virus infection

Pillay, S., Meyer, N. L., Puschnik, A. S., Davulcu, O., Diep, J., Ishikawa, Y., Jae, L. T., Wosen, J. E., Nagamine, C. M., Chapman, M. & Carette, J. E., Feb 4 2016, In : Nature. 530, 7588, p. 108-112 5 p.

Research output: Contribution to journalArticle

Dependovirus
Virus Diseases
Virus Internalization
Tropism
Proteins
4 Citations (Scopus)

The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase

Godsey, M. H., Davulcu, O., Nix, J. C., Skalicky, J. J., Brüschweiler, R. P. & Chapman, M., Oct 4 2016, In : Structure. 24, 10, p. 1658-1667 10 p.

Research output: Contribution to journalArticle

Arginine Kinase
Crystallography
Transition Temperature
Magnetic Resonance Spectroscopy
Hot Temperature
2015
5 Citations (Scopus)

Parsimony in Protein Conformational Change

Chapman, B. K., Davulcu, O., Skalicky, J. J., Brüschweiler, R. P. & Chapman, M., Jan 23 2015, In : Structure. 23, 7, p. 1190-1198 9 p., 3194.

Research output: Contribution to journalArticle

Arginine Kinase
Proteins
Hydrogen Bonding
Least-Squares Analysis
Magnetic Resonance Spectroscopy
15 Citations (Scopus)

The influence of frame alignment with dose compensation on the quality of single particle reconstructions

Spear, J. M., Noble, A. J., Xie, Q., Sousa, D. R., Chapman, M. & Stagg, S. M., Nov 1 2015, In : Journal of Structural Biology. 192, 2, p. 196-203 8 p.

Research output: Contribution to journalArticle

Electrons
Saturn
Cryoelectron Microscopy
Genetic Therapy
Viruses
2014
3 Citations (Scopus)

Backbone resonance assignments of the 42 kDa enzyme arginine kinase in the transition state analogue form

Davulcu, O., Niu, X., Brüschweiler-Li, L., Brüschweiler, R., Skalicky, J. J. & Chapman, M., Oct 1 2014, In : Biomolecular NMR Assignments. 8, 2, p. 335-338 4 p.

Research output: Contribution to journalArticle

Arginine Kinase
Amides
Enzymes
Nitrates
Adenosine Diphosphate

Common hydrogen bond interactions in diverse phosphoryl transfer active sites

Summerton, J. C., Martin, G. M., Evanseck, J. D. & Chapman, M., Sep 19 2014, In : PLoS One. 9, 9, e108310.

Research output: Contribution to journalArticle

active sites
hydrogen
Hydrogen
Catalytic Domain
Hydrogen bonds

ResLog plots: A new metric for the quality of cryo-EM reconstructions

Stagg, S. M., Noble, A. J., Spilman, M. & Chapman, M., Aug 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 1254-1255 2 p.

Research output: Contribution to journalArticle

plots
19 Citations (Scopus)

ResLog plots as an empirical metric of the quality of cryo-EM reconstructions

Stagg, S. M., Noble, A. J., Spilman, M. & Chapman, M., Mar 2014, In : Journal of Structural Biology. 185, 3, p. 418-426 9 p.

Research output: Contribution to journalArticle

X Ray Crystallography
Electron Microscopy
Datasets
Data Accuracy
13 Citations (Scopus)

Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs

Boudko, S. P., Ishikawa, Y., Nix, J., Chapman, M. & Bächinger, H. P., 2014, In : Protein Science. 23, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Peptidylprolyl Isomerase
EF Hand Motifs
Endoplasmic Reticulum
Protein Interaction Domains and Motifs
2013
18 Citations (Scopus)

Atomic modeling of cryo-electron microscopy reconstructions - Joint refinement of model and imaging parameters

Chapman, M., Trzynka, A. & Chapman, B. K., Apr 2013, In : Journal of Structural Biology. 182, 1, p. 10-21 12 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Joints
Boidae
Chaperonins
Viral Structures
18 Citations (Scopus)

Characterization of interactions between heparin/glycosaminoglycan and adeno-associated virus

Zhang, F., Aguilera, J., Beaudet, J. M., Xie, Q., Lerch, T. F., Davulcu, O., Colón, W., Chapman, M. & Linhardt, R. J., Sep 10 2013, In : Biochemistry. 52, 36, p. 6275-6285 11 p.

Research output: Contribution to journalArticle

Dependovirus
Glycosaminoglycans
Viruses
Heparin
Surface Plasmon Resonance
7 Citations (Scopus)

Electron microscopy analysis of a disaccharide analog complex reveals receptor interactions of adeno-associated virus

Xie, Q., Spilman, M., Meyer, N. L., Lerch, T. F., Stagg, S. M. & Chapman, M., Nov 2013, In : Journal of Structural Biology. 184, 2, p. 129-135 7 p.

Research output: Contribution to journalArticle

Dependovirus
Disaccharides
Glycosaminoglycans
Electron Microscopy
Macromolecular Substances
2012
9 Citations (Scopus)

Crystal structures of arginine kinase in complex with ADP, nitrate, and various phosphagen analogs

Clark, S. A., Davulcu, O. & Chapman, M., Oct 12 2012, In : Biochemical and Biophysical Research Communications. 427, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

Arginine Kinase
Ornithine
Nitrates
Adenosine Diphosphate
Crystal structure
7 Citations (Scopus)

Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse

Boudko, S. P., Ishikawa, Y., Lerch, T. F., Nix, J., Chapman, M. & Bächinger, H. P., 2012, In : BMC Research Notes. 5, 626.

Research output: Contribution to journalArticle

Horses
Crystal structure
Mutation
Endoplasmic Reticulum
Connective Tissue
4 Citations (Scopus)

Hyperconjugation-mediated solvent effects in phosphoanhydride bonds

Summerton, J. C., Evanseck, J. D. & Chapman, M., Oct 18 2012, In : Journal of Physical Chemistry A. 116, 41, p. 10209-10217 9 p.

Research output: Contribution to journalArticle

Hydrogen bonds
orbitals
Modulation
hydrogen bonds
Phosphoric Monoester Hydrolases
21 Citations (Scopus)

Identification of the heparin binding site on adeno-associated virus serotype 3B (AAV-3B)

Lerch, T. F. & Chapman, M., Feb 5 2012, In : Virology. 423, 1, p. 6-13 8 p.

Research output: Contribution to journalArticle

Dependovirus
Heparin
Binding Sites
Disaccharides
Genetic Therapy
36 Citations (Scopus)

Structure of AAV-DJ, a retargeted gene therapy vector: Cryo-electron microscopy at 4.5 Å resolution

Lerch, T. F., O'Donnell, J. K., Meyer, N. L., Xie, Q., Taylor, K. A., Stagg, S. M. & Chapman, M., Aug 8 2012, In : Structure. 20, 8, p. 1310-1320 11 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Tropism
Genetic Therapy
Heparitin Sulfate
Liver
47 Citations (Scopus)

Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20

McCraw, D. M., O'Donnell, J. K., Taylor, K. A., Stagg, S. M. & Chapman, M., Sep 15 2012, In : Virology. 431, 1-2, p. 40-49 10 p.

Research output: Contribution to journalArticle

Dependovirus
Neutralizing Antibodies
Cryoelectron Microscopy
Monoclonal Antibodies
Epitope Mapping
2011
28 Citations (Scopus)

Arginine kinase: Joint crystallographic and NMR RDC analyses link substrate-associated motions to intrinsic flexibility

Niu, X., Bruschweiler-Li, L., Davulcu, O., Skalicky, J. J., Brüschweiler, R. & Chapman, M., Jan 14 2011, In : Journal of Molecular Biology. 405, 2, p. 479-496 18 p.

Research output: Contribution to journalArticle

Arginine Kinase
Joints
Horseshoe Crabs
Creatine Kinase
Plastics
11 Citations (Scopus)

Crystal structure of the human collagen XV trimerization domain: A potent trimerizing unit common to multiplexin collagens

Wirz, J., Boudko, S. P., Lerch, T. F., Chapman, M. & Bächinger, H. P., Jan 2011, In : Matrix Biology. 30, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

Collagen
14 Citations (Scopus)

Rate-limiting domain and loop motions in arginine kinase

Davulcu, O., Skalicky, J. J. & Chapman, M., May 17 2011, In : Biochemistry. 50, 19, p. 4011-4018 8 p.

Research output: Contribution to journalArticle

Arginine Kinase
Chemical activation
Enzymes
Adenosine Triphosphate
Substrates
37 Citations (Scopus)

Structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (AAV-6)

Xie, Q., Lerch, T. F., Meyer, N. L. & Chapman, M., Nov 10 2011, In : Virology. 420, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

Dependovirus
Static Electricity
Heparin
Parvovirus
Capsid
12 Citations (Scopus)

Subunit dissociation and metal binding by Escherichia coli apo-manganese superoxide dismutase

Whittaker, M. M., Lerch, T. F., Kirillova, O., Chapman, M. & Whittaker, J., Jan 15 2011, In : Archives of Biochemistry and Biophysics. 505, 2, p. 213-225 13 p.

Research output: Contribution to journalArticle

Escherichia coli
Superoxide Dismutase
Metals
Proteins
Trp-Ser- His-Pro-Gln-Phe-Glu-Lys
16 Citations (Scopus)

The structure of lombricine kinase: Implications for phosphagen kinase conformational changes

Bush, D. J., Kirillova, O., Clark, S. A., Davulcu, O., Fabiola, F., Xie, Q., Somasundaram, T., Ellington, W. R. & Chapman, M., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9338-9350 13 p.

Research output: Contribution to journalArticle

lombricine kinase
Phosphotransferases
Arginine Kinase
Substrates
Crystallography
2010
4 Citations (Scopus)

A pseudo-plaque method for infectious particle assay and clonal isolation of adeno-associated virus

Mitchell, D. A. J., Lerch, T. F., Hare, J. T. & Chapman, M., Dec 2010, In : Journal of Virological Methods. 170, 1-2, p. 9-15 7 p.

Research output: Contribution to journalArticle

Dependovirus
Viral Genome
Virion
Agar
Coloring Agents
6 Citations (Scopus)

De-icing: Recovery of diffraction intensities in the presence of ice rings

Chapman, M. & Somasundaram, T., May 15 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 6, p. 741-744 4 p.

Research output: Contribution to journalArticle

Ice
54 Citations (Scopus)

The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion

Lerch, T. F., Xie, Q. & Chapman, M., Jul 2010, In : Virology. 403, 1, p. 26-36 11 p.

Research output: Contribution to journalArticle

Immune Evasion
Dependovirus
Capsid
Genetic Therapy
Serogroup
2009
73 Citations (Scopus)

Adeno-associated virus-2 and its primary cellular receptor-Cryo-EM structure of a heparin complex

O'Donnell, J., Taylor, K. A. & Chapman, M., Mar 15 2009, In : Virology. 385, 2, p. 434-443 10 p.

Research output: Contribution to journalArticle

Dependovirus
Heparin
Heparan Sulfate Proteoglycans
Cryoelectron Microscopy
Mutagenesis
22 Citations (Scopus)

Crystal Structure of Human Collagen XVIII Trimerization Domain: A Novel Collagen Trimerization Fold

Boudko, S. P., Sasaki, T., Engel, J., Lerch, T. F., Nix, J., Chapman, M. & Bächinger, H. P., Sep 25 2009, In : Journal of Molecular Biology. 392, 3, p. 787-802 16 p.

Research output: Contribution to journalArticle

Collagen Type XVIII
Collagen
Hydroxyproline
Proline
23 Citations (Scopus)

Intrinsic Domain and Loop Dynamics Commensurate with Catalytic Turnover in an Induced-Fit Enzyme

Davulcu, O., Flynn, P. F., Chapman, M. & Skalicky, J. J., Oct 14 2009, In : Structure. 17, 10, p. 1356-1367 12 p.

Research output: Contribution to journalArticle

Catalysis
Enzymes
Arginine Kinase
Adenosine Triphosphate
Arginine
13 Citations (Scopus)

Twinned crystals of adeno-associated virus serotype 3b prove suitable for structural studies

Lerch, T. F., Xie, Q., Ongley, H. M., Hare, J. & Chapman, M., 2009, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Dependovirus
viruses
Viruses
Crystals
Capsid
2008
25 Citations (Scopus)

Anomeric effect in "high energy" phosphate bonds. Selective destabilization of the scissile bond and modulation of the exothermicity of hydrolysis

Ruben, E. A., Plumley, J. A., Chapman, M. & Evanseck, J. D., Mar 19 2008, In : Journal of the American Chemical Society. 130, 11, p. 3349-3358 10 p.

Research output: Contribution to journalArticle

Bond length
Hydrolysis
Phosphates
Modulation
Ground state
13 Citations (Scopus)
Dependovirus
Synchrotrons
Tropism
viruses
Crystallization
2007
8 Citations (Scopus)

Hydrogen bonding mediated by key orbital interactions determines hydration enthalpy differences of phosphate water clusters

Ruben, E. A., Chapman, M. & Evanseck, J. D., Oct 25 2007, In : Journal of Physical Chemistry A. 111, 42, p. 10804-10814 11 p.

Research output: Contribution to journalArticle

Hydration
hydration
Enthalpy
Hydrogen bonds
phosphates

Normalizing Normal Mode Analysis

Chapman, M., Feb 2007, In : Structure. 15, 2, p. 135-136 2 p.

Research output: Contribution to journalArticle

Computer Simulation
Proteins
3'-(1-butylphosphoryl)adenosine
2006
30 Citations (Scopus)

Bias in cross-validated free R factors: Mitigation of the effects of non-crystallographic symmetry

Fabiola, F., Korostelev, A. & Chapman, M., Mar 2006, In : Acta Crystallographica Section D: Biological Crystallography. 62, 3, p. 227-238 12 p.

Research output: Contribution to journalArticle

R Factors
R388
Crystallography
symmetry
Fourier Analysis
11 Citations (Scopus)

Characterization of the capsid protein glycosylation of adeno-associated virus type 2 by high-resolution mass spectrometry

Murray, S., Nilsson, C. L., Hare, J. T., Emmett, M. R., Korostelev, A., Ongley, H., Marshall, A. G. & Chapman, M., Jun 2006, In : Journal of Virology. 80, 12, p. 6171-6176 6 p.

Research output: Contribution to journalArticle

Dependovirus
Capsid Proteins
glycosylation
coat proteins
Glycosylation
61 Citations (Scopus)

Elongation Arrest by SecM via a Cascade of Ribosomal RNA Rearrangements

Mitra, K., Schaffitzel, C., Fabiola, F., Chapman, M., Ban, N. & Frank, J., May 19 2006, In : Molecular Cell. 22, 4, p. 533-543 11 p.

Research output: Contribution to journalArticle

Ribosomal RNA
Transfer RNA
Ribosomes
RNA
Large Ribosome Subunits
19 Citations (Scopus)

Intensity and mosaic spread analysis from PISEMA tensors in solid-state NMR

Quine, J. R., Achuthan, S., Asbury, T., Bertram, R., Chapman, M., Hu, J. & Cross, T. A., Apr 2006, In : Journal of Magnetic Resonance. 179, 2, p. 190-198 9 p.

Research output: Contribution to journalArticle

peptides
Tensors
Nuclear magnetic resonance
tensors
solid state
12 Citations (Scopus)

pipath: An optimized algorithm for generating α-helical structures from PISEMA data

Asbury, T., Quine, J. R., Achuthan, S., Hu, J., Chapman, M., Cross, T. A. & Bertram, R., Nov 2006, In : Journal of Magnetic Resonance. 183, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

Graph theory
Directed graphs
graph theory
Membrane Proteins
Nuclear magnetic resonance
6 Citations (Scopus)

Serotype-specific detection of adeno-associated virus during laboratory preparation

Mitchell, D. A. J., O'Donnell, J., Hare, J. T. & Chapman, M., Sep 2006, In : Journal of Virological Methods. 136, 1-2, p. 277-282 6 p.

Research output: Contribution to journalArticle

Dependovirus
Polymerase Chain Reaction
Serogroup
Capsid
Single-Stranded DNA
2005
92 Citations (Scopus)

Fitting of high-resolution structures into electron microscopy reconstruction images

Fabiola, F. & Chapman, M., Mar 2005, In : Structure. 13, 3, p. 389-400 12 p.

Research output: Contribution to journalArticle

Computer-Assisted Image Processing
Electron Microscopy
Muscle Proteins
X Ray Crystallography
Ribosomes
13 Citations (Scopus)
Protonation
Bond length
Nitrogen
Guanidine
Energy Metabolism
8 Citations (Scopus)

Main chain 1H, 13C, and 15N resonance assignments of the 42-kDa enzyme arginine kinase [7]

Davulcu, O., Clark, S. A., Chapman, M. & Skalicky, J. J., Jun 2005, In : Journal of Biomolecular NMR. 32, 2, p. 178 1 p.

Research output: Contribution to journalArticle

Arginine Kinase
Nitrogen Isotopes
Carbon Isotopes
Protein Conformation
Hydrogen