Matthew Whorton

Assistant Professor

  • 1650 Citations
  • 11 h-Index
20012019

Research output per year

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Research Output

  • 1650 Citations
  • 11 h-Index
  • 15 Article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

Structural basis for mammalian nucleotide sugar transport

Ahuja, S. & Whorton, M., Apr 15 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M., Chen, J. Z. & Shyng, S-L., Jan 16 2017, In : eLife. 6, e24149.

Research output: Contribution to journalArticle

74 Scopus citations
2014

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

Wang, W., Whorton, M. R. & MacKinnon, R., 2014, In : eLife. 3, p. e03671 e03671.

Research output: Contribution to journalArticle

29 Scopus citations
2013

X-ray structure of the mammalian GIRK2-βγ G-protein complex

Whorton, M. R. & MacKinnon, R., Jun 7 2013, In : Nature. 498, 7453, p. 190-197 8 p.

Research output: Contribution to journalArticle

168 Scopus citations
2011

Crystal structure of the mammalian GIRK2 K + channel and gating regulation by G proteins, PIP 2, and sodium

Whorton, M. R. & MacKinnon, R., Sep 30 2011, In : Cell. 147, 1, p. 199-208 10 p.

Research output: Contribution to journalArticle

276 Scopus citations
2009

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

Xiao, J. Y., Ruiz, G. V., Whorton, M. R., Rasmussen, S. G. F., DeVree, B. T., Deupi, X., Sunahara, R. K. & Kobilka, B., Jun 9 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9501-9506 6 p.

Research output: Contribution to journalArticle

163 Scopus citations
2008

Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

Whorton, M. R., Jastrzebska, B., Park, P. S. H., Fotiadis, D., Engel, A., Palczewski, K. & Sunahara, R. K., Feb 15 2008, In : Journal of Biological Chemistry. 283, 7, p. 4387-4394 8 p.

Research output: Contribution to journalArticle

209 Scopus citations
2007

A CE assay for the detection of agonist-stimulated adenylyl cyclase activity

Cunliffe, J. M., Whorton, M. R., Sunahara, R. K. & Kennedy, R. T., Jun 1 2007, In : ELECTROPHORESIS. 28, 12, p. 1913-1920 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

Whorton, M. R., Bokoch, M. P., Rasmussen, S. G. F., Huang, B., Zare, R. N., Kobilka, B. & Sunahara, R. K., May 1 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7682-7687 6 p.

Research output: Contribution to journalArticle

518 Scopus citations

SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5

Benson, M. D., Li, Q. J., Kieckhafer, K., Dudek, D., Whorton, M. R., Sunahara, R. K., Iñiguez-Lluhí, J. A. & Martens, J. R., Feb 6 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 1805-1810 6 p.

Research output: Contribution to journalArticle

104 Scopus citations
2006

ARF6 activation by Gαq signaling: Gαq forms molecular complexes with ARNO and ARF6

Giguère, P., Rochdi, M. D., Laroche, G., Dupré, É., Whorton, M. R., Sunahara, R. K., Claing, A., Dupuis, G. & Parent, J. L., Nov 1 2006, In : Cellular Signalling. 18, 11, p. 1988-1994 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
2005

Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues

Jameson, E. E., Roof, R. A., Whorton, M. H., Mosberg, H. I., Sunahara, R. K., Neubig, R. R. & Kennedy, R. T., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 7712-7719 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2004

Chemical and Functional Analysis of Hydroxyurea Oral Solutions

Heeney, M. M., Whorton, M. R., Howard, T. A., Johnson, C. A. & Ware, R. E., Mar 2004, In : Journal of Pediatric Hematology/Oncology. 26, 3, p. 179-184 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Identification of Hemochromatosis Gene Polymorphisms in Chronically Transfused Patients with Sickle Cell Diseases

Jeng, M. R., Adams-Graves, P., Howard, T. A., Whorton, M. R., Li, C. S. & Ware, R. E., Dec 1 2003, In : American Journal of Hematology. 74, 4, p. 243-248 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2001

Thrombophilic DNA mutations as independent risk factors for stroke and avascular necrosis in sickle cell anemia

Zimmerman, S. A., Howard, T. A., Whorton, M. R., Rosse, W. F., James, A. H. & Ware, R. E., Jan 1 2001, In : Hematology. 6, 5, p. 347-353 7 p.

Research output: Contribution to journalArticle

2 Scopus citations