Matthew Whorton

Assistant Professor

  • 1553 Citations
  • 11 h-Index
20012019
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Research Output 2001 2019

  • 1553 Citations
  • 11 h-Index
  • 15 Article
  • 1 Chapter
  • 1 Comment/debate
4 Citations (Scopus)

A CE assay for the detection of agonist-stimulated adenylyl cyclase activity

Cunliffe, J. M., Whorton, M., Sunahara, R. K. & Kennedy, R. T., Jun 2007, In : Electrophoresis. 28, 12, p. 1913-1920 8 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Assays
G-Protein-Coupled Receptors
Terbutaline
Cell Membrane
1 Citation (Scopus)

Adenylyl Cyclases

Whorton, M. & Sunahara, R. K., Nov 7 2003, Handbook of Cell Signaling. Elsevier Inc., Vol. 2-3. p. 419-426 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adenylyl Cyclases
506 Citations (Scopus)

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

Whorton, M., Bokoch, M. P., Rasmussen, S. G. F., Huang, B., Zare, R. N., Kobilka, B. & Sunahara, R. K., May 1 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7682-7687 6 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
HDL Lipoproteins
G-Protein-Coupled Receptors
GTP-Binding Proteins
Adrenergic Receptors
23 Citations (Scopus)

ARF6 activation by Gαq signaling: Gαq forms molecular complexes with ARNO and ARF6

Giguère, P., Rochdi, M. D., Laroche, G., Dupré, É., Whorton, M., Sunahara, R. K., Claing, A., Dupuis, G. & Parent, J. L., Nov 2006, In : Cellular Signalling. 18, 11, p. 1988-1994 7 p.

Research output: Contribution to journalArticle

Thromboxane Receptors
G-Protein-Coupled Receptors
ADP-ribosylation factor 6
Gq-G11 GTP-Binding Protein alpha Subunits
Guanine Nucleotide Exchange Factors

Calcium-activated proteins visualized

Whorton, M., Dec 11 2014, In : Nature. 516, 7530, p. 176-178 3 p.

Research output: Contribution to journalComment/debate

Chloride Channels
X Ray Crystallography
Calcium
Proteins
29 Citations (Scopus)

Chemical and Functional Analysis of Hydroxyurea Oral Solutions

Heeney, M. M., Whorton, M., Howard, T. A., Johnson, C. A. & Ware, R. E., Mar 2004, In : Journal of Pediatric Hematology/Oncology. 26, 3, p. 179-184 6 p.

Research output: Contribution to journalArticle

Hydroxyurea
Capsules
Temperature
Water
T-Lymphocytes
62 Citations (Scopus)

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M., Chen, J. Z. & Shyng, S-L., Jan 16 2017, In : eLife. 6, e24149.

Research output: Contribution to journalArticle

KATP Channels
Glyburide
Adenosine Triphosphate
Hypoglycemic Agents
Conformations
253 Citations (Scopus)

Crystal structure of the mammalian GIRK2 K + channel and gating regulation by G proteins, PIP 2, and sodium

Whorton, M. & MacKinnon, R., Sep 30 2011, In : Cell. 147, 1, p. 199-208 10 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Crystal structure
Sodium
Physiology
Heart Rate
203 Citations (Scopus)

Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

Whorton, M., Jastrzebska, B., Park, P. S. H., Fotiadis, D., Engel, A., Palczewski, K. & Sunahara, R. K., Feb 15 2008, In : Journal of Biological Chemistry. 283, 7, p. 4387-4394 8 p.

Research output: Contribution to journalArticle

Transducin
Rhodopsin
Phospholipids
Oligomerization
HDL Lipoproteins
10 Citations (Scopus)

Identification of Hemochromatosis Gene Polymorphisms in Chronically Transfused Patients with Sickle Cell Diseases

Jeng, M. R., Adams-Graves, P., Howard, T. A., Whorton, M., Li, C. S. & Ware, R. E., Dec 2003, In : American Journal of Hematology. 74, 4, p. 243-248 6 p.

Research output: Contribution to journalArticle

Hemochromatosis
Sickle Cell Anemia
Mutation
African Americans
Genes
26 Citations (Scopus)

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

Wang, W., Whorton, M. & MacKinnon, R., 2014, In : eLife. 3, p. e03671

Research output: Contribution to journalArticle

Membrane Lipids
GTP-Binding Proteins
Lipids
Neurons
Pacemakers
31 Citations (Scopus)

Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues

Jameson, E. E., Roof, R. A., Whorton, M., Mosberg, H. I., Sunahara, R. K., Neubig, R. R. & Kennedy, R. T., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 7712-7719 8 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Guanosine Triphosphate
GTP-Binding Proteins
Assays
GTP-Binding Protein Regulators
2 Citations (Scopus)

Structural basis for mammalian nucleotide sugar transport

Ahuja, S. & Whorton, M., Apr 15 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Sugars
Nucleotides
Cytidine Monophosphate N-Acetylneuraminic Acid
Glycosylation
Substrates
99 Citations (Scopus)

SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5

Benson, M. D., Li, Q. J., Kieckhafer, K., Dudek, D., Whorton, M., Sunahara, R. K., Iñiguez-Lluhí, J. A. & Martens, J. R., Feb 6 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 1805-1810 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Ubiquitin
Sumoylation
Blood Vessels
Ubiquitins
156 Citations (Scopus)

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

Xiao, J. Y., Ruiz, G. V., Whorton, M., Rasmussen, S. G. F., DeVree, B. T., Deupi, X., Sunahara, R. K. & Kobilka, B., Jun 9 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9501-9506 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
GTP-Binding Proteins
Adrenergic Receptors
Ligands
Adrenergic Agonists
2 Citations (Scopus)

Thrombophilic DNA mutations as independent risk factors for stroke and avascular necrosis in sickle cell anemia

Zimmerman, S. A., Howard, T. A., Whorton, M., Rosse, W. F., James, A. H. & Ware, R. E., 2001, In : Hematology. 6, 5, p. 347-353 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Necrosis
Stroke
Mutation
DNA
146 Citations (Scopus)

X-ray structure of the mammalian GIRK2-βγ G-protein complex

Whorton, M. & MacKinnon, R., 2013, In : Nature. 498, 7453, p. 190-197 8 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
X-Rays
Inwardly Rectifying Potassium Channel
Protein Subunits
G-Protein-Coupled Receptors