Mary Wirtz

Research Associate Professor

  • 1694 Citations
  • 21 h-Index
1980 …2018

Research output per year

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Research Output

  • 1694 Citations
  • 21 h-Index
  • 42 Article
  • 5 Review article
  • 1 Chapter
  • 1 Short survey
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Article
2014

Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma

Keller, K. E., Yang, Y. F., Sun, Y. Y., Sykes, R., Gaudette, N. D., Samples, J. R., Acott, T. S. & Wirtz, M. K., Mar 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 267-276 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013
17 Scopus citations
2012

Microenvironmental regulation by fibrillin-1

Sengle, G., Tsutsui, K., Keene, D. R., Tufa, S. F., Carlson, E. J., Charbonneau, N. L., Ono, R. N., Sasaki, T., Wirtz, M. K., Samples, J. R., Fessler, L. I., Fessler, J. H., Sekiguchi, K., Hayflick, S. J. & Sakai, L. Y., Jan 2012, In : PLoS genetics. 8, 1, e1002425.

Research output: Contribution to journalArticle

64 Scopus citations

Variants in ASB10 are associated with open-angle glaucoma

Pasutto, F., Keller, K. E., Weisschuh, N., Sticht, H., Samples, J. R., Yang, Y. F., Zenkel, M., Schlötzer-Schrehardt, U., Mardin, C. Y., Frezzotti, P., Edmunds, B., Kramer, P. L., Gramer, E., Reis, A., Acott, T. S. & Wirtz, M. K., Mar 2012, In : Human molecular genetics. 21, 6, p. 1336-1349 14 p., ddr572.

Research output: Contribution to journalArticle

52 Scopus citations
2010

Association of POAG risk factors and the Thr377met MYOC mutation in an isolated greek population

Wirtz, M. K., Samples, J. R., Toumanidou, V., Charlesworth, J., Mikropoulos, D. G., Kaltsos, K., Economou, A., Dimopoulos, A., Georgiadou, I. N., Moumtzis, G., Papanastasiou, A., Kramer, P. L., Dyer, T., Blangero, J. & Konstas, A. G. P., Jun 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3055-3060 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Primary open angle glaucoma due to T377M MYOC: Population mapping of a Greek founder mutation in Northwestern Greece

Kitsos, G., Petrou, Z., Grigoriadou, M., Samples, J. R., Hewitt, A. W., Kokotas, H., Giannoulia-Karantana, A., Mackey, D. A., Wirtz, M. K., Moschou, M., Ioannidis, J. P. A. & Petersen, M. B., 2010, In : Clinical Ophthalmology. 4, 1, p. 171-178 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The path to open-angle glaucoma gene discovery: Endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness

Charlesworth, J., Kramer, P. L., Dyer, T., Diego, V., Samples, J. R., Craig, J. E., Mackey, D. A., Hewitt, A. W., Blangero, J. & Wirtz, M. K., Jul 2010, In : Investigative Ophthalmology and Visual Science. 51, 7, p. 3509-3514 6 p.

Research output: Contribution to journalArticle

66 Scopus citations
2008

Myocilin variations and familial glaucoma in Taxiarchis, a small Greek village

Wirtz, M. K., Konstas, A. G. P., Samples, J. R., Kaltsos, K., Economou, A., Dimopoulos, A., Georgiadou, I. & Petersen, M. B., Apr 25 2008, In : Molecular vision. 14, p. 774-781 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2007

Clinical Features Associated With an Asp380His Myocilin Mutation in a US Family With Primary Open-Angle Glaucoma

Wirtz, M. K., Samples, J. R., Choi, D. & Gaudette, N. D., Jul 2007, In : American journal of ophthalmology. 144, 1, p. 75-80.e2

Research output: Contribution to journalArticle

8 Scopus citations

Differential expression profile prioritization of positional candidate glaucoma genes: The GLC1C locus

Rozsa, F. W., Scott, K. M., Pawar, H., Samples, J. R., Wirtz, M. K. & Richards, J. E., Jan 2007, In : Archives of ophthalmology. 125, 1, p. 117-127 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds

Hewitt, A. W., Samples, J. R., Allingham, R. R., Järvelä, I., Kitsos, G., Krishnadas, S. R., Richards, J. E., Lichter, P. R., Petersen, M. B., Sundaresan, P., Wiggs, J. L., Mackey, D. A. & Wirtz, M. K., Apr 8 2007, In : Molecular vision. 13, p. 487-492 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2006

A large GLC1C Greek family with a myocilin T377M mutation: Inheritance and phenotypic variability

Petersen, M. B., Kitsos, G., Samples, J. R., Gaudette, N. D., Economou-Petersen, E., Sykes, R., Rust, K., Grigoriadou, M., Aperis, G., Choi, D., Psilas, K., Craig, J. E., Kramer, P. L., Mackey, D. A. & Wirtz, M. K., Feb 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 2, p. 620-625 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region

Kramer, P. L., Samples, J. R., Monemi, S., Sykes, R., Sarfarazi, M. & Wirtz, M. K., Sep 19 2006, In : Archives of ophthalmology. 124, 9, p. 1328-1331 4 p.

Research output: Contribution to journalArticle

36 Scopus citations
2004

Refining the primary open-angle glaucoma GLC1C region on chromosome 3 by haplotype analysis

Samples, J. R., Kitsos, G., Economou-Petersen, E., Steinkamp, P., Sykes, R., Rust, K., Patzer, C., Grigoriadou, M., Aperis, G., Psilas, K., Petersen, M. B. & Wirtz, M. K., Jan 1 2004, In : Clinical Genetics. 65, 1, p. 40-44 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2003

In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome

Faivre, L., Gorlin, R. J., Wirtz, M. K., Godfrey, M., Dagoneau, N., Samples, J. R., Le Merrer, M., Collod-Beroud, G., Boileau, C., Munnich, A. & Cormier-Daire, V., Jan 1 2003, In : Journal of medical genetics. 40, 1, p. 34-36 3 p.

Research output: Contribution to journalArticle

Open Access
183 Scopus citations
2002

Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library

Wirtz, M. K., Samples, J. R., Xu, H., Severson, T. & Acott, T. S., Dec 1 2002, In : Investigative Ophthalmology and Visual Science. 43, 12, p. 3698-3704 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2001

Genetic linkage of autosomal dominant primary open angle glaucoma to chromosome 3q in a greek pedigree

Kitsos, G., Eiberg, H., Economou-Petersen, E., Wirtz, M. K., Kramer, P. L., Aspiotis, M., Tommerup, N., Petersen, M. B. & Psilas, K., Jul 7 2001, In : European Journal of Human Genetics. 9, 6, p. 452-457 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
2000
28 Scopus citations
1999

GLC1F, a new primary open-angle glaucoma locus, maps to 7q35-q36

Wirtz, M. K., Samples, J. R., Rust, K., Lie, J., Nordling, L. A., Schilling, K., Acott, T. S. & Kramer, P. L., Feb 1999, In : Archives of ophthalmology. 117, 2, p. 237-241 5 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations
1998

Age-related macular degeneration: Clinical features in a large family and linkage to chromosome 1q

Klein, M. L., Schultz, D. W., Edwards, A., Matise, T. C., Rust, K., Berselli, C. B., Trzupek, K., Weleber, R. G., Ott, J., Wirtz, M. K. & Acott, T. S., Aug 1998, In : Archives of ophthalmology. 116, 8, p. 1082-1088 7 p.

Research output: Contribution to journalArticle

Open Access
195 Scopus citations

Insulin-like growth factor binding protein-5 expression by human trabecular meshwork

Wirtz, M. K., Xu, H., Rust, K., Alexander, J. P. & Acott, T. S., Jan 1 1998, In : Investigative Ophthalmology and Visual Science. 39, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Malattia leventinese: Refinement of the genetic locus and phenotypic variability in autosomal dominant macular drusen

Edwards, A. O., Klein, M. L., Berselli, C. B., Hejtmancik, J. F., Rust, K., Wirtz, M. K., Weleber, R. G. & Acott, T. S., Sep 1 1998, In : American journal of ophthalmology. 126, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
1997

Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid

Vranka, J. A., Johnson, E., Zhu, X., Shepardson, A., Alexander, J. P., Bradley, J. M. B., Wirtz, M. K., Weleber, R. G., Klein, M. L. & Acott, T. S., Mar 17 1997, In : Current Eye Research. 16, 2, p. 102-110 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q

Wirtz, M. K., Samples, J. R., Kramer, P. L., Rust, K., Topinka, J. R., Yount, J., Koler, R. D. & Acott, T. S., Feb 1 1997, In : American Journal of Human Genetics. 60, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

188 Scopus citations

Proteoglycan expression by human trabecular meshworks

Wirtz, M. K., Bradley, J. M. B., Xu, H., Domreis, J., Nobis, C. A., Truesdale, A. T., Samples, J. R., Van Buskirk, E. M. & Acott, T. S., Jun 6 1997, In : Current Eye Research. 16, 5, p. 412-421 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
1996

TIMP3 expression in the human retina and choroid

Vranka, J. A., Shepardson, A., Johnson, E. C., Zhu, X. H., Alexander, J. P., Bradley, J. M. B., Wirtz, M. K., Weleber, R. G., Klein, M. L. & Acott, T. S., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S273

Research output: Contribution to journalArticle

4 Scopus citations

Weill-Marchesani syndrome: Association with fibrillin-1

Wirtz, M. K., Kramer, P. L., Rust, K. & Samples, J. R., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S34

Research output: Contribution to journalArticle

Weill-Marchesani syndrome - Possible linkage of the autosomal dominant form to 15q21.1

Wirtz, M. K., Samples, J. R., Kramer, P. L., Rust, K., Yount, J., Acott, T. S., Koler, R. D., Cisler, J., Jahed, A., Gorlin, R. J. & Godfrey, M., Oct 2 1996, In : American Journal of Medical Genetics. 65, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
1993

A cysteine for glycine substitution at position 175 in an α1 (i) chain of type I collagen produces a clinically heterogeneous form of osteogenesis imperfecta

Wirtz, M. K., Rao, V. H., Glanville, R. W., Labhard, M. E., Pretorius, P. J., de Vries, W. N., de Wet, W. J. & Hollister, D. W., Jan 1 1993, In : Connective Tissue Research. 29, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
1992

Repeated helical epitopes of defined amino acid sequence in human type III collagen identified by monoclonal antibodies

Hisae, H., Keene, D. R., Sakai, L. Y., Wirtz, M. K., Bächinger, H. P., Godfrey, M. & Hollister, D. W., Jun 1992, In : Molecular Immunology. 29, 6, p. 759-770 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
1991

Characterization of a COL1A1 splicing defect in a case of Ehlers-Danlos syndrome type VII: Further evidence of molecular homogeneity

D'Alessio, M., Ramirez, F., Blumberg, B. D., Wirtz, M. K., Rao, V. H., Godfrey, M. D. & Hollister, D. W., Dec 1 1991, In : American Journal of Human Genetics. 49, 2, p. 400-406 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
1990

In vivo and in vitro noncovalent association of excised α1(I) amino-terminal propeptides with mutant pNα2(I) collagen chains in native mutant collagen in a case of Ehlers-Danlos syndrome, type VII

Wirtz, M. K., Keene, D. R., Hori, H., Glanville, R. W., Steinmann, B., Rao, V. H. & Hollister, D. W., May 16 1990, In : Journal of Biological Chemistry. 265, 11, p. 6312-6317 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
1989
15 Scopus citations

Temperature-dependent expression of a collagen splicing defect in the fibroblasts of a patient with Ehlers-Danlos syndrome Type VII

Weil, D., D'Alessio, M., Ramirez, F., Steinmann, B., Wirtz, M. K., Glanville, R. W. & Hollister, D. W., Jan 1 1989, In : Journal of Biological Chemistry. 264, 28, p. 16804-16809 6 p.

Research output: Contribution to journalArticle

67 Scopus citations
1988

A cysteine for glycine substitution at position 1017 in an α1(I) chain of type I collagen in a patient with mild dominantly inherited osteogenesis imperfecta

Labhard, M. E., Wirtz, M. K., Pope, F. M., Nicholls, A. C. & Hollister, D. W., Dec 1 1988, In : Molecular Biology and Medicine. 5, 3, p. 197-207 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of a mutation that causes exon skipping during collagen pre-mRNA splicing in an Ehlers-Danlos syndrome variant

Weil, D., Bernard, M., Combates, N., Wirtz, M. K., Hollister, D. W., Steinmann, B. & Ramirez, F., Jan 1 1988, In : Journal of Biological Chemistry. 263, 18, p. 8561-8564 4 p.

Research output: Contribution to journalArticle

71 Scopus citations
1987

Ehlers-Danlos syndrome type VIIB. Deletion of 18 amino acids comprising the N-telopeptide region of a Pro-α2(I) chain

Wirtz, M. K., Glanville, R. W., Steinmann, B., Rao, V. H. & Hollister, D. W., Dec 1 1987, In : Journal of Biological Chemistry. 262, 34, p. 16376-16385 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
1985
4 Scopus citations
1983

Delineation of the catalytic components of the NADPH-dependent O2- generating oxidoreductase of human neutrophils

Green, T. R., Wirtz, M. K. & Wu, D. E., Feb 10 1983, In : Biochemical and Biophysical Research Communications. 110, 3, p. 873-879 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
13 Scopus citations
1982

Gyrate atrophy of the choroid and retina: Clinical and biochemical heterogeneity and response to vitamin B6

Weleber, R. G., Wirtz, M. K. & Kennaway, N. G., Dec 1 1982, In : Birth Defects: Original Article Series. 18, 6, p. 219-230 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
1980

Amino acid and enzyme studies of brain and other tissues in an infant with argininosuccinic aciduria

Perry, T. L., Wirtz, M. L. K., Kennaway, N. G., Edward Hsia, Y., Atienza, F. C. & Uemura, H. S., Jan 1 1980, In : Clinica Chimica Acta. 105, 2, p. 257-267 11 p.

Research output: Contribution to journalArticle

15 Scopus citations