Mary Wirtz

Research Associate Professor

  • 1576 Citations
  • 20 h-Index
1980 …2020
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Research Output 1980 2018

  • 1576 Citations
  • 20 h-Index
  • 47 Article
  • 1 Chapter
  • 1 Short survey
2018
3 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. & 37 othersKnepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J., Wirtz, M., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. & Stamer, W. D., Jun 1 2018, In : Experimental Eye Research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort survey

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure
2016
4 Citations (Scopus)

The role of the IL-20 subfamily in glaucoma

Wirtz, M. & Keller, K., 2016, In : Mediators of Inflammation. 2016, 4083735.

Research output: Contribution to journalArticle

Glaucoma
Inbred DBA Mouse
Pedigree
Optic Nerve
Intraocular Pressure
4 Citations (Scopus)

Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma

Keller, K. & Wirtz, M., Mar 2 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Ankyrins
Glaucoma
Proteolysis
Cytokines
Proteins
2014

Glaucoma risk factors: Family history – the genetics of glaucoma

Samples, J. R. & Wirtz, M., Jan 1 2014, Clinical Glaucoma Care: The Essentials. Springer New York, p. 45-56 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glaucoma
Open Angle Glaucoma
Genes
Genetic Loci
Macular Degeneration
10 Citations (Scopus)

Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma

Keller, K., Yang, Y. F., Sun, Y. Y., Sykes, R., Gaudette, N. D., Samples, J. R., Acott, T. & Wirtz, M., Mar 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 267-276 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Glaucoma
Matrix Metalloproteinases
Mutation
Fibroblasts
2013
16 Citations (Scopus)
Ankyrin Repeat
Trabecular Meshwork
Ubiquitin
Cytokines
HSP70 Heat-Shock Proteins
2012
53 Citations (Scopus)

Microenvironmental regulation by fibrillin-1

Sengle, G., Tsutsui, K., Keene, D. R., Tufa, S. F., Carlson, E. J., Charbonneau, N. L., Ono, R. N., Sasaki, T., Wirtz, M., Samples, J. R., Fessler, L. I., Fessler, J. H., Sekiguchi, K., Hayflick, S. & Sakai, L., Jan 2012, In : PLoS Genetics. 8, 1, e1002425.

Research output: Contribution to journalArticle

Weill-Marchesani Syndrome
mutation
Microfibrils
Marfan Syndrome
Mutation
44 Citations (Scopus)

Variants in ASB10 are associated with open-angle glaucoma

Pasutto, F., Keller, K., Weisschuh, N., Sticht, H., Samples, J. R., Yang, Y. F., Zenkel, M., Schlötzer-Schrehardt, U., Mardin, C. Y., Frezzotti, P., Edmunds, L. B., Kramer, P. L., Gramer, E., Reis, A., Acott, T. & Wirtz, M., Mar 2012, In : Human Molecular Genetics. 21, 6, p. 1336-1349 14 p., ddr572.

Research output: Contribution to journalArticle

Ankyrin Repeat
Retinal Ganglion Cells
Open Angle Glaucoma
Glaucoma
Suppressor of Cytokine Signaling Proteins
2010
5 Citations (Scopus)

Association of POAG risk factors and the Thr377met MYOC mutation in an isolated greek population

Wirtz, M., Samples, J. R., Toumanidou, V., Charlesworth, J., Mikropoulos, D. G., Kaltsos, K., Economou, A., Dimopoulos, A., Georgiadou, I. N., Moumtzis, G., Papanastasiou, A., Kramer, P. L., Dyer, T., Blangero, J. & Konstas, A. G. P., Jun 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3055-3060 6 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Mutation
Genetic Association Studies
Pedigree
2 Citations (Scopus)

Primary open angle glaucoma due to T377M MYOC: Population mapping of a Greek founder mutation in Northwestern Greece

Kitsos, G., Petrou, Z., Grigoriadou, M., Samples, J. R., Hewitt, A. W., Kokotas, H., Giannoulia-Karantana, A., Mackey, D. A., Wirtz, M., Moschou, M., Ioannidis, J. P. A. & Petersen, M. B., 2010, In : Clinical Ophthalmology. 4, 1, p. 171-178 8 p.

Research output: Contribution to journalArticle

Greece
Mutation
Population
Primary Open Angle Glaucoma
Gene Amplification
59 Citations (Scopus)

The path to open-angle glaucoma gene discovery: Endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness

Charlesworth, J., Kramer, P. L., Dyer, T., Diego, V., Samples, J. R., Craig, J. E., Mackey, D. A., Hewitt, A. W., Blangero, J. & Wirtz, M., Jul 2010, In : Investigative Ophthalmology and Visual Science. 51, 7, p. 3509-3514 6 p.

Research output: Contribution to journalArticle

Open Angle Glaucoma
Genetic Association Studies
Intraocular Pressure
Endophenotypes
Pedigree
2008
9 Citations (Scopus)

Myocilin variations and familial glaucoma in Taxiarchis, a small Greek village

Wirtz, M., Konstas, A. G. P., Samples, J. R., Kaltsos, K., Economou, A., Dimopoulos, A., Georgiadou, I. & Petersen, M. B., Apr 25 2008, In : Molecular Vision. 14, p. 774-781 8 p.

Research output: Contribution to journalArticle

Glaucoma
Mutation
Greece
Incidence
Optic Nerve
2007
8 Citations (Scopus)

Clinical Features Associated With an Asp380His Myocilin Mutation in a US Family With Primary Open-Angle Glaucoma

Wirtz, M., Samples, J. R., Choi, D. & Gaudette, N. D., Jul 2007, In : American Journal of Ophthalmology. 144, 1

Research output: Contribution to journalArticle

Mutation
Intraocular Pressure
Glaucoma
Helsinki Declaration
High Pressure Liquid Chromatography
7 Citations (Scopus)

Differential expression profile prioritization of positional candidate glaucoma genes: The GLC1C locus

Rozsa, F. W., Scott, K. M., Pawar, H., Samples, J. R., Wirtz, M. & Richards, J. E., Jan 2007, In : Archives of Ophthalmology. 125, 1, p. 117-127 11 p.

Research output: Contribution to journalArticle

Glaucoma
Genes
Trabecular Meshwork
Transcription Factors
Gene Expression
10 Citations (Scopus)

Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds

Hewitt, A. W., Samples, J. R., Allingham, R. R., Järvelä, I., Kitsos, G., Krishnadas, S. R., Richards, J. E., Lichter, P. R., Petersen, M. B., Sundaresan, P., Wiggs, J. L., Mackey, D. A. & Wirtz, M., 2007, In : Molecular Vision. 13, p. 487-492 6 p.

Research output: Contribution to journalArticle

Founder Effect
Glaucoma
Greece
Mutation
HapMap Project
2006
16 Citations (Scopus)

A large GLC1C Greek family with a myocilin T377M mutation: Inheritance and phenotypic variability

Petersen, M. B., Kitsos, G., Samples, J. R., Gaudette, N. D., Economou-Petersen, E., Sykes, R., Rust, K., Grigoriadou, M., Aperis, G., Choi, D., Psilas, K., Craig, J. E., Kramer, P. L., Mackey, D. A. & Wirtz, M., Feb 2006, In : Investigative Ophthalmology and Visual Science. 47, 2, p. 620-625 6 p.

Research output: Contribution to journalArticle

Mutation
Genes
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Glaucoma
35 Citations (Scopus)

The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region

Kramer, P. L., Samples, J. R., Monemi, S., Sykes, R., Sarfarazi, M. & Wirtz, M., 2006, In : Archives of Ophthalmology. 124, 9, p. 1328-1331 4 p.

Research output: Contribution to journalArticle

Chromosomes
Genes
Mutation
Single Nucleotide Polymorphism
WD40 Repeats
2004
16 Citations (Scopus)

Refining the primary open-angle glaucoma GLC1C region on chromosome 3 by haplotype analysis

Samples, J. R., Kitsos, G., Economou-Petersen, E., Steinkamp, P., Sykes, R., Rust, K., Patzer, C., Grigoriadou, M., Aperis, G., Psilas, K., Petersen, M. B. & Wirtz, M., Jan 2004, In : Clinical Genetics. 65, 1, p. 40-44 5 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 3
Haplotypes
Microsatellite Repeats
Genetic Recombination
DNA
2003
173 Citations (Scopus)

In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome

Faivre, L., Gorlin, R. J., Wirtz, M., Godfrey, M., Dagoneau, N., Samples, J. R., Le Merrer, M., Collod-Beroud, G., Boileau, C., Munnich, A. & Cormier-Daire, V., Jan 1 2003, In : Journal of Medical Genetics. 40, 1, p. 34-36 3 p.

Research output: Contribution to journalArticle

Weill-Marchesani Syndrome
Gene Deletion
Chromosomes
Brachydactyly
Genes

Introductory ophthalmic genetics

Samples, J. R. & Wirtz, M., Dec 2003, In : Ophthalmology Clinics of North America. 16, 4, p. 501-503 3 p.

Research output: Contribution to journalArticle

Genetic Therapy
Molecular Biology
Cell Biology
Therapeutics
4 Citations (Scopus)

The genetic loci of open-angle glaucoma

Wirtz, M. & Samples, J. R., Dec 2003, In : Ophthalmology Clinics of North America. 16, 4, p. 505-514 10 p.

Research output: Contribution to journalArticle

Genetic Loci
Open Angle Glaucoma
Blindness
Genetic Research
Genes
2002
26 Citations (Scopus)

Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library

Wirtz, M., Samples, J. R., Xu, H., Severson, T. & Acott, T., Dec 1 2002, In : Investigative Ophthalmology and Visual Science. 43, 12, p. 3698-3704 7 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Expressed Sequence Tags
Complementary DNA
Clone Cells
Genome
2001
26 Citations (Scopus)

Genetic linkage of autosomal dominant primary open angle glaucoma to chromosome 3q in a greek pedigree

Kitsos, G., Eiberg, H., Economou-Petersen, E., Wirtz, M., Kramer, P. L., Aspiotis, M., Tommerup, N., Petersen, M. B. & Psilas, K., 2001, In : European Journal of Human Genetics. 9, 6, p. 452-457 6 p.

Research output: Contribution to journalArticle

Genetic Linkage
Pedigree
Chromosomes
Open Angle Glaucoma
Lod Score
2000
28 Citations (Scopus)
Collagen Type I
Glaucoma
Trabecular Meshwork
Proteins
Expressed Sequence Tags
1999
157 Citations (Scopus)

GLC1F, a new primary open-angle glaucoma locus, maps to 7q35-q36

Wirtz, M., Samples, J. R., Rust, K., Lie, J., Nordling, L., Schilling, K., Acott, T. & Kramer, P. L., Feb 1999, In : Archives of Ophthalmology. 117, 2, p. 237-241 5 p.

Research output: Contribution to journalArticle

Visual Fields
Intraocular Pressure
Genome
Lod Score
Primary Open Angle Glaucoma
1998
193 Citations (Scopus)

Age-related macular degeneration: Clinical features in a large family and linkage to chromosome 1q

Klein, M., Schultz, D. W., Edwards, A., Matise, T. C., Rust, K., Berselli, C. B., Trzupek, K., Weleber, R., Ott, J., Wirtz, M. & Acott, T., Aug 1998, In : Archives of Ophthalmology. 116, 8, p. 1082-1088 7 p.

Research output: Contribution to journalArticle

Macular Degeneration
Chromosomes
Geographic Atrophy
Genes
Lod Score
28 Citations (Scopus)

Insulin-like growth factor binding protein-5 expression by human trabecular meshwork

Wirtz, M., Xu, H., Rust, K., Alexander, J. P. & Acott, T., Jan 1998, In : Investigative Ophthalmology and Visual Science. 39, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 5
Trabecular Meshwork
IGF Type 1 Receptor
Ciliary Body
Insulin-Like Growth Factor II
25 Citations (Scopus)

Malattia leventinese: Refinement of the genetic locus and phenotypic variability in autosomal dominant macular drusen

Edwards, A. O., Klein, M., Berselli, C. B., Hejtmancik, J. F., Rust, K., Wirtz, M., Weleber, R. & Acott, T., Sep 1998, In : American Journal of Ophthalmology. 126, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

Genetic Loci
Genes
Optic Disk
Geographic Atrophy
Lod Score
9 Citations (Scopus)

Prospects for genetic intervention in primary open-angle glaucoma

Wirtz, M., Acott, T., Samples, J. R. & Morrison, J., 1998, In : Drugs and Aging. 13, 5, p. 333-340 8 p.

Research output: Contribution to journalArticle

Genetic Engineering
Glaucoma
Genes
Primary Open Angle Glaucoma
Retinal Degeneration
1997
54 Citations (Scopus)

Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid

Vranka, J., Johnson, E., Zhu, X., Shepardson, A., Alexander, J. P., Bradley, J. M. B., Wirtz, M., Weleber, R., Klein, M. & Acott, T., 1997, In : Current Eye Research. 16, 2, p. 102-110 9 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Choroid
Retina
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-2
186 Citations (Scopus)

Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q

Wirtz, M., Samples, J. R., Kramer, P. L., Rust, K., Topinka, J. R., Yount, J., Koler, R. D. & Acott, T., Feb 1997, In : American Journal of Human Genetics. 60, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

Chromosome Mapping
Chromosomes
Glaucoma
Genes
Blindness
32 Citations (Scopus)

Proteoglycan expression by human trabecular meshworks

Wirtz, M., Bradley, J. M. B., Xu, H., Domreis, J., Nobis, C. A., Truesdale, A. T., Samples, J. R., Van Buskirk, E. M. & Acott, T., 1997, In : Current Eye Research. 16, 5, p. 412-421 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Proteoglycans
Versicans
Biglycan
Decorin
1996
4 Citations (Scopus)

TIMP3 expression in the human retina and choroid

Vranka, J., Shepardson, A., Johnson, E., Zhu, X. H., Alexander, J. P., Bradley, J. M. B., Wirtz, M., Weleber, R., Klein, M. & Acott, T., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Choroid
Tissue Inhibitor of Metalloproteinase-3
Bruch Membrane
Retina
Messenger RNA

Weill-Marchesani syndrome: Association with fibrillin-1

Wirtz, M., Kramer, P. L., Rust, K. & Samples, J. R., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Weill-Marchesani Syndrome
Ectopia Lentis
Microsatellite Repeats
Chromosome Mapping
Myopia
37 Citations (Scopus)

Weill-Marchesani syndrome - Possible linkage of the autosomal dominant form to 15q21.1

Wirtz, M., Samples, J. R., Kramer, P. L., Rust, K., Yount, J., Acott, T., Koler, R. D., Cisler, J., Jahed, A., Gorlin, R. J. & Godfrey, M., Oct 2 1996, In : American Journal of Medical Genetics. 65, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Weill-Marchesani Syndrome
Ectopia Lentis
Brachydactyly
Staining and Labeling
Glaucoma
1993
8 Citations (Scopus)

A cysteine for glycine substitution at position 175 in an α1 (i) chain of type I collagen produces a clinically heterogeneous form of osteogenesis imperfecta

Wirtz, M., Rao, V. H., Glanville, R. W., Labhard, M. E., Pretorius, P. J., de Vries, W. N., de Wet, W. J. & Hollister, D. W., 1993, In : Connective Tissue Research. 29, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Osteogenesis Imperfecta
Collagen Type I
Glycine
Cysteine
Substitution reactions
1992
11 Citations (Scopus)

Repeated helical epitopes of defined amino acid sequence in human type III collagen identified by monoclonal antibodies

Hisae, H., Keene, D. R., Sakai, L., Wirtz, M., Bächinger, H. P., Godfrey, M. & Hollister, D. W., 1992, In : Molecular Immunology. 29, 6, p. 759-770 12 p.

Research output: Contribution to journalArticle

Collagen Type III
Epitopes
Amino Acid Sequence
Monoclonal Antibodies
Antibodies
1991
26 Citations (Scopus)

Characterization of a COLIAI splicing defect in a case of Ehlers-Danlos syndrome type VII: Further evidence of molecular homogeneity

D'Alessio, M., Ramirez, F., Blumberg, B. D., Wirtz, M., Rao, V. H., Godfrey, M. D. & Hollister, D. W., Aug 1991, In : American Journal of Human Genetics. 49, 2, p. 400-406 7 p.

Research output: Contribution to journalArticle

Ehlers-Danlos Syndrome
Collagen
Exons
RNA Splice Sites
Collagen Type I
1990
6 Citations (Scopus)

In vivo and in vitro noncovalent association of excised α1(i) amino-terminal propeptides with mutant pnα2(I) collagen chains in native mutant collagen in a case of Ehlers-Danlos syndrome, type VII

Wirtz, M., Keene, D. R., Hori, H., Glanville, R. W., Steinmann, B., Rao, V. H. & Hollister, D. W., 1990, In : Journal of Biological Chemistry. 265, 11, p. 6312-6317 6 p.

Research output: Contribution to journalArticle

Ehlers-Danlos Syndrome
Collagen
Collagen Type I
Molecules
Procollagen N-Endopeptidase
1989
15 Citations (Scopus)
Gyrate Atrophy
Ornithine-Oxo-Acid Transaminase
Vitamin B 6
Pyridoxine
Pyridoxal Phosphate
63 Citations (Scopus)

Temperature-dependent expression of a collagen splicing defect in the fibroblasts of a patient with Ehlers-Danlos syndrome Type VII

Weil, D., D'Alessio, M., Ramirez, F., Steinmann, B., Wirtz, M., Glanville, R. W. & Hollister, D. W., 1989, In : Journal of Biological Chemistry. 264, 28, p. 16804-16809 6 p.

Research output: Contribution to journalArticle

Ehlers-Danlos Syndrome
Fibroblasts
Exons
Collagen
Defects
1988
6 Citations (Scopus)

A cysteine for glycine substitution at position 1017 in an α1(I) chain of type I collagen in a patient with mild dominantly inherited osteogenesis imperfecta

Labhard, M. E., Wirtz, M., Pope, F. M., Nicholls, A. C. & Hollister, D. W., 1988, In : Molecular Biology and Medicine. 5, 3, p. 197-207 11 p.

Research output: Contribution to journalArticle

Osteogenesis Imperfecta
Peptide Fragments
Molecular Cloning
Collagen Type I
Glycine
68 Citations (Scopus)

Identification of a mutation that causes exon skipping during collagen pre-mRNA splicing in an Ehlers-Danlos syndrome variant

Weil, D., Bernard, M., Combates, N., Wirtz, M., Hollister, D. W., Steinmann, B. & Ramirez, F., 1988, In : Journal of Biological Chemistry. 263, 18, p. 8561-8564 4 p.

Research output: Contribution to journalArticle

Ehlers-Danlos Syndrome
RNA Precursors
Exons
Collagen
Mutation
1987
38 Citations (Scopus)

Ehlers-Danlos syndrome type VIIB. Deletion of 18 amino acids comprising the N-telopeptide region of a Pro-α2(I) chain

Wirtz, M., Glanville, R. W., Steinmann, B., Rao, V. H. & Hollister, D. W., 1987, In : Journal of Biological Chemistry. 262, 34, p. 16376-16385 10 p.

Research output: Contribution to journalArticle

Ehlers-Danlos Syndrome
Amino Acids
Peptides
Collagen
RNA Splicing
1985
4 Citations (Scopus)
Gyrate Atrophy
Vitamin B 6
Fibroblasts
Ornithine-Oxo-Acid Transaminase
Pyridoxine
1983
13 Citations (Scopus)

Delineation of the catalytic components of the NADPH-dependent O2- generating oxidoreductase of human neutrophils

Green, T. R., Wirtz, M. & Wu, D. E., Feb 10 1983, In : Biochemical and Biophysical Research Communications. 110, 3, p. 873-879 7 p.

Research output: Contribution to journalArticle

NADP
Oxidoreductases
Neutrophils
Chromophores
Chronic Granulomatous Disease
13 Citations (Scopus)
Magnesium
Catalyst activity
Oxidoreductases
Neutrophils
Calcium
1982
8 Citations (Scopus)
Gyrate Atrophy
Vitamin B 6
Genetic Heterogeneity
Mutation
Pyridoxal Phosphate
1980
14 Citations (Scopus)

Amino acid and enzyme studies of brain and other tissues in an infant with argininosuccinic aciduria

Perry, T. L., Wirtz, M., Kennaway, N. G., Edward Hsia, Y., Atienza, F. C. & Uemura, H. S., Jan 1 1980, In : Clinica Chimica Acta. 105, 2, p. 257-267 11 p.

Research output: Contribution to journalArticle

Argininosuccinic Aciduria
Argininosuccinic Acid
Brain
Tissue
Amino Acids