• 29158 Citations
  • 83 h-Index
1976 …2021
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Research Output 1979 2019

  • 29158 Citations
  • 83 h-Index
  • 198 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Chapter
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Article
2001
135 Citations (Scopus)

Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy

Casazza, J. P., Betts, M. R., Picker, L. & Koup, R. A., 2001, In : Journal of Virology. 75, 14, p. 6508-6516 9 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus
Highly Active Antiretroviral Therapy
T-lymphocytes
deterioration
HIV
72 Citations (Scopus)

Factors affecting the efficiency of CD8+ T cell cross-priming with exogenous antigens

Maecker, H. T., Ghanekar, S. A., Suni, M. A., He, X. S., Picker, L. & Maino, V. C., Jun 15 2001, In : Journal of Immunology. 166, 12, p. 7268-7275 8 p.

Research output: Contribution to journalArticle

Cross-Priming
T-Lymphocytes
Antigens
Dendritic Cells
Tissue Donors
55 Citations (Scopus)

Gamma interferon expression in CD8+ T cells is a marker for circulating cytotoxic T lymphocytes that recognize an HLA a2-restricted epitope of human cytomegalovirus phosphoprotein pp65

Ghanekar, S. A., Nomura, L. E., Suni, M. A., Picker, L., Maecker, H. T. & Maino, V. C., 2001, In : Clinical and Diagnostic Laboratory Immunology. 8, 3, p. 628-631 4 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
T-cells
Phosphoproteins
Cytotoxic T-Lymphocytes
Cytomegalovirus
266 Citations (Scopus)

Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry

McKenna, R. W., Washington, L. T., Aquino, D. B., Picker, L. & Kroft, S. H., Oct 15 2001, In : Blood. 98, 8, p. 2498-2507 10 p.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
Lymphocytes
Flow cytometry
Flow Cytometry
Bone
87 Citations (Scopus)

Immunophenotypic analysis of peripheral T-cell neoplasms: A multiparameter flow cytometric approach

Jamal, S., Picker, L., Aquino, D. B., McKenna, R. W., Dawson, D. B. & Kroft, S. H., Oct 2001, In : American Journal of Clinical Pathology. 116, 4, p. 512-526 15 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Population
CD3 Antigens
Antigens
58 Citations (Scopus)

Impairment of Gag-specific CD8+ T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques

Hel, Z., Nacsa, J., Kelsall, B., Tsai, W. P., Letvin, N., Parks, R. W., Tryniszewska, E., Picker, L., Lewis, M. G., Edghill-Smith, Y., Moniuszko, M., Pal, R., Stevceva, L., Altman, J. D., Allen, T. M., Watkins, D., Torres, J. V., Berzofsky, J. A., Belyakov, I. M., Strober, W. & 1 others, Franchini, G., 2001, In : Journal of Virology. 75, 23, p. 11483-11495 13 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Human immunodeficiency virus
Macaca
T-lymphocytes
6 Citations (Scopus)

Recently identified measures of human thymic function

MacFarland R.D., R. D., Picker, L., Koup, R. A. & Douek, D. C., Nov 2001, In : Clinical and Applied Immunology Reviews. 2, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Thymus Gland
Iatrogenic Disease
Virus Diseases
T-Cell Antigen Receptor
40 Citations (Scopus)

The cutaneous response in humans to Treponema pallidum lipoprotein analogues involves cellular elements of both innate and adaptive immunity

Sellati, T. J., Waldrop, S. L., Salazar, J. C., Bergstresser, P. R., Picker, L. & Radolf, J. D., Mar 15 2001, In : Journal of Immunology. 166, 6, p. 4131-4140 10 p.

Research output: Contribution to journalArticle

Treponema pallidum
Adaptive Immunity
Blister
Innate Immunity
Lipoproteins
2000
46 Citations (Scopus)

De novo CD5+ diffuse large B-cell lymphomas: A heterogeneous group containing an unusual form of splenic lymphoma

Kroft, S. H., Howard, M. S., Picker, L., Ansari, M. Q., Aquino, D. B. & McKenna, R. W., Oct 2000, In : American Journal of Clinical Pathology. 114, 4, p. 523-533 11 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Lymphoma
185 Citations (Scopus)

Identification of a human recent thymic emigrant phenotype

McFarland, R. D., Douek, D. C., Koup, R. A. & Picker, L., Apr 11 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 8, p. 4215-4220 6 p.

Research output: Contribution to journalArticle

Forensic Anthropology
T-Lymphocytes
Phenotype
T-Cell Antigen Receptor
Thymectomy
39 Citations (Scopus)

Immunofluorescence analysis of T-cell responses in health and disease

Maecker, H. T., Maino, V. C. & Picker, L., 2000, In : Journal of Clinical Immunology. 20, 6, p. 391-399 9 p.

Research output: Contribution to journalArticle

Fluorescent Antibody Technique
T-Lymphocytes
Health
Mitogens
Flow Cytometry
3 Citations (Scopus)

Proving HIV-1 immunity: New tools offer new opportunities

Picker, L., 2000, In : Journal of Clinical Investigation. 105, 10, p. 1333-1334 2 p.

Research output: Contribution to journalArticle

AIDS Vaccines
Cytotoxic T-Lymphocytes
HIV Infections
HIV-1
Immunity
136 Citations (Scopus)

Putative immunodominant human immunodeficiency virus-specific CD8+ T-cell responses cannot be predicted by major histocompatibility complex class I haplotype

Betts, M. R., Casazza, J. P., Patterson, B. A., Waldrop, S., Trigona, W., Fu, T. M., Kern, F., Picker, L. & Koup, R. A., 2000, In : Journal of Virology. 74, 19, p. 9144-9151 8 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus
major histocompatibility complex
Major Histocompatibility Complex
Haplotypes
epitopes
38 Citations (Scopus)

The CD4+ T cell response to HIV-1

Picker, L. & Maino, V. C., Aug 1 2000, In : Current Opinion in Immunology. 12, 4, p. 381-386 6 p.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Virus Diseases
HIV Infections
Viruses
1999
27 Citations (Scopus)

An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro

McCoig, C., Van Dyke, G., Chou, C. S., Picker, L., Ramilo, O. & Vitetta, E. S., Sep 28 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11482-11485 4 p.

Research output: Contribution to journalArticle

Immunotoxins
HIV-1
T-Lymphocytes
Highly Active Antiretroviral Therapy
In Vitro Techniques
121 Citations (Scopus)

Distribution of human CMV-specific memory T cells among the CD8(pos.) subsets defined by CD57, CD27, and CD45 isoforms

Kern, F., Khatamzas, E., Surel, I., Frömmel, C., Reinke, P., Waldrop, S. L., Picker, L. & Volk, H. D., 1999, In : European Journal of Immunology. 29, 9, p. 2908-2915 8 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Protein Isoforms
T-Lymphocytes
Phenotype
Immunologic Memory
105 Citations (Scopus)

Evidence for superantigen involvement in skin homing of T cells in atopic dermatitis

Strickland, I., Hauk, P. J., Trumble, A. E., Picker, L. & Leung, D. Y. M., 1999, In : Journal of Investigative Dermatology. 112, 2, p. 249-253 5 p.

Research output: Contribution to journalArticle

Superantigens
T-cells
Atopic Dermatitis
Skin
T-Lymphocytes
T Lymphocyte Differentiation Antigens
CD Antigens
CD4-Positive T-Lymphocytes
C-Type Lectins
Cell Separation
654 Citations (Scopus)

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged vital suppression

Pitcher, C. J., Quittner, C., Peterson, D. M., Connors, M., Koup, R. A., Maino, V. C. & Picker, L., 1999, In : Nature Medicine. 5, 5, p. 518-525 8 p.

Research output: Contribution to journalArticle

T-cells
HIV Infections
HIV-1
T-Lymphocytes
Data storage equipment
1998
1451 Citations (Scopus)

Changes in thymic function with age and during the treatment of HIV infection

Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan, J. L., Jamieson, B. D., Zack, J. A., Picker, L. & Koup, R. A., Dec 17 1998, In : Nature. 396, 6712, p. 690-695 6 p.

Research output: Contribution to journalArticle

HIV Infections
T-Lymphocytes
Highly Active Antiretroviral Therapy
Thymus Gland
Therapeutics
240 Citations (Scopus)

Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry

Suni, M. A., Picker, L. & Maino, V. C., Mar 1 1998, In : Journal of Immunological Methods. 212, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

Flow Cytometry
Cytokines
T-Lymphocytes
Antigens
Aptitude
188 Citations (Scopus)

Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression

Maino, V. C. & Picker, L., Oct 15 1998, In : Communications in Clinical Cytometry. 34, 5, p. 207-215 9 p.

Research output: Contribution to journalArticle

Flow Cytometry
Cytokines
Antigens
Leukocytes
T-Lymphocytes
166 Citations (Scopus)

Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis

Waldrop, S. L., Davis, K. A., Maino, V. C. & Picker, L., Nov 15 1998, In : Journal of Immunology. 161, 10, p. 5284-5295 12 p.

Research output: Contribution to journalArticle

Cytokines
T-Lymphocytes
Interleukin-2
Immune System
Viruses
1997
368 Citations (Scopus)

Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin

Olweus, J., BitMansour, A., Warnke, R., Thompson, P. A., Carballido, J., Picker, L. & Lund-Johansen, F., Nov 11 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 23, p. 12551-12556 6 p.

Research output: Contribution to journalArticle

Cell Lineage
Dendritic Cells
Interleukin-3 Receptors
Langerhans Cells
T-Lymphocytes
470 Citations (Scopus)

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry. Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency

Waldrop, S. L., Pitcher, C. J., Peterson, D. M., Maino, V. C. & Picker, L., Apr 1 1997, In : Journal of Clinical Investigation. 99, 7, p. 1739-1750 12 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Flow Cytometry
HIV
T-Lymphocytes
Antigens
50 Citations (Scopus)

Human recombinant interferon-β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors

McRae, B. L., Picker, L. & Van Seventer, G. A., Oct 1997, In : European Journal of Immunology. 27, 10, p. 2650-2656 7 p.

Research output: Contribution to journalArticle

Interferons
Cytokines
T-Lymphocytes
Interleukin-12
L-Selectin
15 Citations (Scopus)

Immune reconstitution with donor-derived memory/effector T cells after orthotopic liver transplantation

Collins R.H., J., Sackler, M., Pitcher, C. J., Waldrop, S. L., Klintmalm, G. B., Jenkins, R. & Picker, L., 1997, In : Experimental Hematology. 25, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

Liver Transplantation
Hematopoietic Stem Cell Transplantation
Tissue Donors
T-Lymphocytes
Lymphopoiesis
67 Citations (Scopus)
Cell Differentiation
Lymphocytes
Cytokines
T-Lymphocytes
Phenotype
107 Citations (Scopus)

U.S.-Canadian consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: Data analysis and interpretation

Borowitz, M. J., Bray, R., Gascoyne, R., Melnick, S., Parker, J. W., Picker, L. & Stetler-Stevenson, M., Oct 15 1997, In : Communications in Clinical Cytometry. 30, 5, p. 236-244 9 p.

Research output: Contribution to journalArticle

Flow Cytometry
Differential Diagnosis
Neoplasms
Phenotype
Light
1996
336 Citations (Scopus)

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway

DeGrendele, H. C., Estess, P., Picker, L. & Siegelman, M. H., Mar 1 1996, In : Journal of Experimental Medicine. 183, 3, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

Cell Adhesion
Selectins
Endothelial Cells
Lymphocytes
Ligands
28 Citations (Scopus)

Immunodetection of histone epitopes correlates with early stages of apoptosis in activated human peripheral T lymphocytes

Zunino, S. J., Singh, M. K., Bass, J. & Picker, L., Aug 1996, In : American Journal of Pathology. 149, 2, p. 653-663 11 p.

Research output: Contribution to journalArticle

Histones
Epitopes
Apoptosis
T-Lymphocytes
DNA Breaks
2388 Citations (Scopus)

Lymphocyte homing and homeostasis

Butcher, E. C. & Picker, L., Apr 5 1996, In : Science. 272, 5258, p. 60-66 7 p.

Research output: Contribution to journalArticle

Homeostasis
Lymphocytes
Lymphocyte Subsets
Population Dynamics
24 Citations (Scopus)

Neutrophil adhesion to 24-hour IL-1-stimulated endothelial cells under flow conditions

Jones, D. A., Smith, C. W., Picker, L. & McIntire, L. V., Jul 15 1996, In : Journal of Immunology. 157, 2, p. 858-863 6 p.

Research output: Contribution to journalArticle

Interleukin-1
Neutrophils
Endothelial Cells
L-Selectin
Selectins
220 Citations (Scopus)

Primary body cavity-based AIDS-related lymphomas

Ansari, M. Q., Dawson, D. B., Nador, R., Rutherford, C., Schneider, N. R., Latimer, M. J., Picker, L., Knowles, D. M. & McKenna, R. W., Feb 1996, In : American Journal of Clinical Pathology. 105, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

AIDS-Related Lymphoma
Lymphoma
Acquired Immunodeficiency Syndrome
CD45 Antigens
Anaplastic Large-Cell Lymphoma
1995
278 Citations (Scopus)

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production

Leung, D. Y. M., Gately, M., Trumble, A., Ferguson-Darnell, B., Schlievert, P. M. & Picker, L., Feb 1 1995, In : Journal of Experimental Medicine. 181, 2, p. 747-753 7 p.

Research output: Contribution to journalArticle

Lymphocyte Homing Receptors
Superantigens
Interleukin-12
T-Lymphocytes
Antigens
241 Citations (Scopus)

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen

Babi, L. F. S., Picker, L., Soler, M. T. P., Drzimalla, K., Flohr, P., Blaser, K. & Hauser, C., 1995, In : Journal of Experimental Medicine. 181, 5, p. 1935-1940 6 p.

Research output: Contribution to journalArticle

Lymphocyte Homing Receptors
Allergic Contact Dermatitis
Atopic Dermatitis
Allergens
T-Lymphocytes
473 Citations (Scopus)

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

Picker, L., Singh, M. K., Zdraveski, Z., Treer, J. R., Waldrop, S. L., Bergstresser, P. R. & Maino, V. C., 1995, In : Blood. 86, 4, p. 1408-1419 12 p.

Research output: Contribution to journalArticle

T-cells
Flow cytometry
Flow Cytometry
Demonstrations
Cytokines
53 Citations (Scopus)

Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation

Tortorella, C., Schulze-Koops, H., Thomas, R., Splawski, J. B., Davis, L. S., Picker, L. & Lipsky, P. E., 1995, In : Journal of Immunology. 155, 1, p. 149-162 14 p.

Research output: Contribution to journalArticle

Cell Differentiation
B-Lymphocytes
T-Lymphocytes
Interleukin-4
Mitomycin
116 Citations (Scopus)
Integrin alpha4beta1
Lymphocyte Function-Associated Antigen-1
Endothelial Cells
Lymphocytes
Cytokines
196 Citations (Scopus)

Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen

Abernathy-Carver, K. J., Sampson, H. A., Picker, L. & Leung, D. Y. M., 1995, In : Journal of Clinical Investigation. 95, 2, p. 913-918 6 p.

Research output: Contribution to journalArticle

Eczema
Milk
Lymphocytes
T-Lymphocytes
Antigens
48 Citations (Scopus)

Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice

Racila, E., Scheuermann, R. H., Picker, L., Yefenof, E., Tucker, T., Chang, W., Marches, R., Street, N. E., Vitetta, E. S. & Uhr, J. W., Apr 1 1995, In : Journal of Experimental Medicine. 181, 4, p. 1539-1550 12 p.

Research output: Contribution to journalArticle

SCID Mice
B-Cell Lymphoma
Antibodies
Immunoglobulin M
Neoplasms
31 Citations (Scopus)

Tumour dormancy and cell signalling - III: Role of hypercrosslinking of IgM and CD40 on the induction of cell cycle arrest and apoptosis in B lymphoma cells

Marches, R., Racila, E., Tucker, T. F., Picker, L., Mongini, P., Hsueh, R., Vitetta, E. S., Scheuermann, R. H. & Uhr, J. W., 1995, In : Therapeutic Immunology. 2, 3, p. 125-136 12 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Cell Cycle Checkpoints
Immunoglobulin M
Apoptosis
Monoclonal Antibodies
1994
84 Citations (Scopus)

Anti-CD19 nhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

Ghetie, M. A., Picker, L., Richardson, J. A., Tucker, K., Uhr, J. W. & Vitetta, E. S., Mar 1 1994, In : Blood. 83, 5, p. 1329-1336 8 p.

Research output: Contribution to journalArticle

SCID Mice
Cell Cycle Checkpoints
Tumors
B-Lymphocytes
Cells
151 Citations (Scopus)

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions

Jones, D. A., McIntire, L. V., Smith, C. W. & Picker, L., Dec 1994, In : Journal of Clinical Investigation. 94, 6, p. 2443-2450 8 p.

Research output: Contribution to journalArticle

Cell Communication
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Endothelial Cells
Integrins
166 Citations (Scopus)

Control of lymphocyte homing

Picker, L., 1994, In : Current Opinion in Immunology. 6, 3, p. 394-406 13 p.

Research output: Contribution to journalArticle

Lymphocytes
Lymphocyte Subsets
Lymphoid Tissue
Endothelium
Immunity
164 Citations (Scopus)

Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites

Picker, L., Martin, R. J., Trumble, A., Newman, L. S., Collins, P. A., Bergstresser, P. R. & Leung, D. Y. M., Jun 1994, In : European Journal of Immunology. 24, 6, p. 1269-1277 9 p.

Research output: Contribution to journalArticle

Lymphocyte Homing Receptors
Integrins
T-Lymphocytes
Lung
Skin
48 Citations (Scopus)

Expression of monoclonal antibody HECA-452 - defined E-selectin ligands on Langerhans cells in normal and diseased skin

Koszik, F., Strunk, D., Simonitsch, I., Picker, L., Stingl, G. & Payer, E., May 1994, In : Journal of Investigative Dermatology. 102, 5, p. 773-780 8 p.

Research output: Contribution to journalArticle

E-Selectin
Langerhans Cells
Skin Diseases
Skin
Monoclonal Antibodies
53 Citations (Scopus)

Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells

Scheuermann, R. H., Racila, E., Tucker, T., Yefenof, E., Street, N. E., Vitetta, E. S., Picker, L. & Uhr, J. W., Apr 26 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 9, p. 4048-4052 5 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Cell Cycle Checkpoints
Protein-Tyrosine Kinases
Apoptosis
Immunoglobulins
108 Citations (Scopus)

Skin disease-related T cells bind to endothelial selectins: Expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding

Rossiter, H., Van Reijsen, F., Mudde, G. C., Kalthoff, F., Bruijnzeel-Koomen, C. A. F. M., Picker, L. J. & Picker, L., Jan 1994, In : European Journal of Immunology. 24, 1, p. 205-210 6 p.

Research output: Contribution to journalArticle

Selectins
P-Selectin
E-Selectin
Skin Diseases
Lymphocytes
1993
55 Citations (Scopus)
Cutaneous T-Cell Lymphoma
Lymphocytes
T-Lymphocytes
Antigens
Skin