Leslie Muldoon

Associate Professor

  • 5095 Citations
  • 41 h-Index
1985 …2019
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Research Output 1985 2019

  • 5095 Citations
  • 41 h-Index
  • 102 Article
  • 1 Conference contribution
  • 1 Review article
2019

Combined iron oxide nanoparticle ferumoxytol and gadolinium contrast enhanced MRI define glioblastoma pseudoprogression

Barajas, R., Hamilton, B., Schwartz, D., Mcconnell, H. L., Pettersson, D., Horvath, A., Szidonya, L., Varallyay, C. G., Firkins, J., Jaboin, J., Kubicky, C. D., Raslan, A., Dogan, A., Cetas, J., Ciporen, J., Han, S. J., Ambady, P., Muldoon, L., Woltjer, R. R., Rooney, W. & 1 others, Neuwelt, E., Mar 18 2019, In : Neuro-Oncology. 21, 4, p. 517-526 10 p.

Research output: Contribution to journalArticle

Open Access
Ferrosoferric Oxide
Gadolinium
Glioblastoma
Nanoparticles
Isocitrate Dehydrogenase
2018
1 Citation (Scopus)

Cerebral blood volume mapping with ferumoxytol in dynamic susceptibility contrast perfusion MRI: Comparison to standard of care

Varallyay, C. G., Nesbit, E., Horvath, A., Varallyay, P., Fu, R. R., Gahramanov, S., Muldoon, L., Li, X., Rooney, W. & Neuwelt, E., Jan 1 2018, (Accepted/In press) In : Journal of Magnetic Resonance Imaging.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Standard of Care
Perfusion
Noise
Putamen
2017
41 Citations (Scopus)

Current and potential imaging applications of ferumoxytol for magnetic resonance imaging

Toth, G. B., Varallyay, C. G., Horvath, A., Bashir, M. R., Choyke, P. L., Daldrup-Link, H. E., Dosa, E., Finn, J. P., Gahramanov, S., Harisinghani, M., Macdougall, I., Neuwelt, A., Vasanawala, S. S., Ambady, P., Barajas, R., Cetas, J., Ciporen, J., Deloughery, T., Doolittle, N., Fu, R. R. & 13 others, Grinstead, J., Guimaraes, A., Hamilton, B., Li, X., McConnell, H. L., Muldoon, L., Nesbit, G., Netto, J. P., Petterson, D., Rooney, W., Schwartz, D., Szidonya, L. & Neuwelt, E., Jul 1 2017, In : Kidney International. 92, 1, p. 47-66 20 p.

Research output: Contribution to journalReview article

Ferrosoferric Oxide
Magnetic Resonance Imaging
Contrast Media
Central Nervous System
Atlases
1 Citation (Scopus)

Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors

Ambady, P., Wu, Y. J., Walker, J. M., Kersch, C., Pagel, M. A., Woltjer, R. R., Fu, R. R., Muldoon, L. & Neuwelt, E., Aug 1 2017, In : Cancer Gene Therapy. 24, 8, p. 348-357 10 p.

Research output: Contribution to journalArticle

Morpholinos
Methyltransferases
Radiation
DNA
temozolomide
6 Citations (Scopus)

High αv integrin level of cancer cells is associated with development of brain metastasis in athymic rats

Wu, Y. J., Pagel, M. A., Muldoon, L., Fu, R. R. & Neuwelt, E., Aug 1 2017, In : Anticancer Research. 37, 8, p. 4029-4040 12 p.

Research output: Contribution to journalArticle

Nude Rats
Integrins
Neoplasm Metastasis
Brain
Neoplasms
2016
13 Citations (Scopus)

Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific

McConnell, H. L., Schwartz, D. L., Richardson, B. E., Woltjer, R. R., Muldoon, L. & Neuwelt, E., Aug 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 6, p. 1535-1542 8 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Nanoparticles
Magnetic resonance
Brain
Imaging techniques
7 Citations (Scopus)
temozolomide
Intra Arterial Infusions
Neoplasm Metastasis
Brain
Poisons
1 Citation (Scopus)

Outwitting the Blood-Brain Barrier

Neuwelt, E., Ambady, P., Muldoon, L., McConnell, H. & Doolittle, N., Nov 15 2016, In : Oncology (Williston Park, N.Y.). 30, 11

Research output: Contribution to journalArticle

Blood-Brain Barrier
2015
5 Citations (Scopus)
Drug Dose Response Relationship
Gadolinium
Contrast Media
Seizures
Central Nervous System
9 Citations (Scopus)

Interactions between αv-Integrin and HER2 and their role in the invasive phenotype of breast cancer cells in vitro and in rat brain

Lal, S., Kersch, C., Beeson, K. A., Wu, Y. J., Muldoon, L. & Neuwelt, E., Jul 29 2015, In : PLoS One. 10, 7, e0131842.

Research output: Contribution to journalArticle

integrins
Integrins
breast neoplasms
Rats
Brain
13 Citations (Scopus)

N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models

Muldoon, L., Wu, Y. J., Pagel, M. A. & Neuwelt, E., 2015, In : Journal of Neuro-Oncology. 121, 3, p. 433-440 8 p.

Research output: Contribution to journalArticle

Acetylcysteine
Cisplatin
Pediatrics
Tumor Burden
Neoplasms
27 Citations (Scopus)

Unsanctifying the sanctuary: Challenges and opportunities with brain metastases

Puhalla, S., Elmquist, W., Freyer, D., Kleinberg, L., Adkins, C., Lockman, P., McGregor, J., Muldoon, L., Nesbit, G., Peereboom, D., Smith, Q., Walker, S. & Neuwelt, E., May 1 2015, In : Neuro-Oncology. 17, 5, p. 639-651 13 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Brain
Blood-Brain Barrier
Therapeutics
Neoplasms
21 Citations (Scopus)
Brain Neoplasms
Vascular Endothelial Growth Factor A
Aminoisobutyric Acids
Blood Vessels
Permeability
2014
32 Citations (Scopus)

Delivery of chemotherapeutics across the blood-brain barrier: Challenges and advances

Doolittle, N., Muldoon, L., Culp, A. Y. & Neuwelt, E., 2014, In : Advances in Pharmacology. 71, p. 203-243 41 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Brain Neoplasms
Central Nervous System
Drug Therapy
Nanoparticles
53 Citations (Scopus)

Evaluation of pseudoprogression in patients with glioblastoma multiforme using dynamic magnetic resonance imaging with ferumoxytol calls RANO criteria into question

Nasseri, M., Gahramanov, S., Netto, J. P., Fu, R. R., Muldoon, L., Varallyay, C., Hamilton, B. & Neuwelt, E., 2014, In : Neuro-Oncology. 16, 8, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Glioblastoma
Chemoradiotherapy
Magnetic Resonance Imaging
Magnetic Resonance Angiography
2013
9 Citations (Scopus)

Acetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma

Wu, Y. J. J., Neuwelt, A. J., Muldoon, L. & Neuwelt, E., Jun 2013, In : Anticancer Research. 33, 6, p. 2391-2400 10 p.

Research output: Contribution to journalArticle

Acetaminophen
Carcinoma
Glutathione
Ovarian Neoplasms
Neoplasms

Blood-tumor barrier normalization effects on cytotoxic drug delivery to brain tumors

Pishko, G. L., Nasseri, M., Gahramanov, S., Muldoon, L. & Neuwelt, E., 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. Vol. 1 A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Drug delivery
Brain Neoplasms
Tumors
Brain
Blood
58 Citations (Scopus)
Ferrosoferric Oxide
Central Nervous System Neoplasms
Nanoparticles
Central Nervous System
Pathology
123 Citations (Scopus)

Immunologic privilege in the central nervous system and the blood-brain barrier

Muldoon, L., Alvarez, J. I., Begley, D. J., Boado, R. J., Del Zoppo, G. J., Doolittle, N., Engelhardt, B., Hallenbeck, J. M., Lonser, R. R., Ohlfest, J. R., Prat, A., Scarpa, M., Smeyne, R. J., Drewes, L. R. & Neuwelt, E., Jan 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Central Nervous System
Cerebrovascular Disorders
Brain
Neurosciences
29 Citations (Scopus)

Inhibition of SUR1 decreases the vascular permeability of cerebral metastases

Thompson, E. M., Pishko, G. L., Muldoon, L. & Neuwelt, E., 2013, In : Neoplasia (United States). 15, 5, p. 535-543 9 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Capillary Permeability
Glyburide
Neoplasm Metastasis
Zonula Occludens-1 Protein
66 Citations (Scopus)

Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma

Doolittle, N., Korfel, A., Lubow, M. A., Schorb, E., Schlegel, U., Rogowski, S., Fu, R. R., Dósa, E., Illerhaus, G., Kraemer, D., Muldoon, L., Calabrese, P., Hedrick, N., Tyson, R. M., Jahnke, K., Maron, L., Butler, R. W. & Neuwelt, E., Jul 2 2013, In : Neurology. 81, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

Neuroimaging
Cognition
Lymphoma
Quality of Life
Radiotherapy
13 Citations (Scopus)

Preservation of cognitive function in primary CNS lymphoma survivors a median of 12 years after enhanced chemotherapy delivery

Doolittle, N., Dósa, E., Fu, R. R., Muldoon, L., Maron, L., Lubow, M. A., Tyson, R. M., Lacy, C. A., Kraemer, D., Butler, R. W. & Neuwelt, E., Nov 1 2013, In : Journal of Clinical Oncology. 31, 31, p. 4026-4027 2 p.

Research output: Contribution to journalArticle

Cognition Disorders
Central Nervous System Neoplasms
Neuropsychological Tests
Antineoplastic Agents
Cognition
91 Citations (Scopus)
Ferrosoferric Oxide
Magnetic Resonance Angiography
Glioblastoma
Radiotherapy
Survival
2012
34 Citations (Scopus)

Targeting αv-integrins decreased metastasis and increased survival in a nude rat breast cancer brain metastasis model

Wu, Y. J., Muldoon, L., Gahramanov, S., Kraemer, D., Marshall, D. J. & Neuwelt, E., Oct 2012, In : Journal of Neuro-Oncology. 110, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

Nude Rats
Integrins
Brain Neoplasms
Breast Neoplasms
Neoplasm Metastasis
2011
27 Citations (Scopus)

Dynamic magnetic resonance imaging assessment of vascular targeting agent effects in rat intracerebral tumor models

Muldoon, L., Gahramanov, S., Li, X., Marshall, D. J., Kraemer, D. & Neuwelt, E., Jan 2011, In : Neuro-Oncology. 13, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Blood Vessels
Magnetic Resonance Imaging
Neoplasms
Capillary Permeability
Integrins
19 Citations (Scopus)

Imaging and therapy with rituximab anti-CD20 immunotherapy in an animal model of central nervous system lymphoma

Muldoon, L., Lewin, S. J., Dósa, E., Kraemer, D., Pagel, M. A., Doolittle, N. & Neuwelt, E., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2207-2215 9 p.

Research output: Contribution to journalArticle

Immunotherapy
Blood-Brain Barrier
Lymphoma
Central Nervous System
Animal Models
31 Citations (Scopus)
gadodiamide
Ferrosoferric Oxide
Magnetic Resonance Angiography
Blood Volume
Tumor Burden
32 Citations (Scopus)

Magnetic resonance imaging of intracranial tumors: Intra-patient comparison of gadoteridol and ferumoxytol

Dósa, E., Guillaume, D. J., Haluska, M., Lacy, C. A., Hamilton, B., Njus, J. M., Rooney, W., Kraemer, D., Muldoon, L. & Neuwelt, E., Feb 2011, In : Neuro-Oncology. 13, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Magnetic Resonance Imaging
Magnetic Resonance Angiography
Neoplasms
Perfusion
47 Citations (Scopus)

MRI using ferumoxytol improves the visualization of central nervous system vascular malformations

Dósa, E., Tuladhar, S., Muldoon, L., Hamilton, B., Rooney, W. & Neuwelt, E., Jun 2011, In : Stroke. 42, 6, p. 1581-1588 8 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Central Nervous System Vascular Malformations
Vascular Malformations
Telangiectasis
Arteriovenous Malformations
103 Citations (Scopus)
Ferrosoferric Oxide
blood volume
progressions
magnetic resonance
tumors
2010
23 Citations (Scopus)

Characterizing the HER2/neu status and metastatic potential of breast cancer stem/progenitor cells

Pommier, S. E. J., Quan, G. G., Christante, D., Muller, P., Newell, A. E. H., Olson, S., Diggs, B., Muldoon, L., Neuwelt, E. & Pommier, R., Feb 2010, In : Annals of Surgical Oncology. 17, 2, p. 613-623 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Stem Cells
Breast Neoplasms
Breast
Neoplasms
38 Citations (Scopus)

Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination

Li, X., Rooney, W., Várallyay, C. G., Gahramanov, S., Muldoon, L., Goodman, J. A., Tagge, I. J., Selzer, A. H., Pike, M., Neuwelt, E. & Springer, C. J., Oct 2010, In : Journal of Magnetic Resonance. 206, 2, p. 190-199 10 p.

Research output: Contribution to journalArticle

Blood Volume Determination
blood volume
Glioma
Magnetic resonance imaging
rats
322 Citations (Scopus)
Nanoparticles
Central Nervous System
Magnetic Resonance Imaging
Pathology
Nervous System Trauma
2009
23 Citations (Scopus)

Bevacizumab and carboplatin increase survival and asymptomatic tumor volume in a glioma model

Jahnke, K., Muldoon, L., Varallyay, C. G., Lewin, S. J., Kraemer, D. & Neuwelt, E., Apr 2009, In : Neuro-Oncology. 11, 2, p. 142-150 9 p.

Research output: Contribution to journalArticle

Carboplatin
Tumor Burden
Glioma
Survival
Nude Rats
30 Citations (Scopus)

Cyclophosphamide enhances human tumor growth in nude rat xenografted tumor models

Wu, Y. J., Muldoon, L., Dickey, D. T., Lewin, S. J., Varallyay, C. G. & Neuwelt, E., Feb 2009, In : Neoplasia. 11, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

Nude Rats
Cyclophosphamide
Growth
Neoplasms
Glioma
66 Citations (Scopus)

Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model

Varallyay, C. G., Muldoon, L., Gahramanov, S., Wu, Y. J., Goodman, J. A., Li, X., Pike, M. & Neuwelt, E., Apr 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 4, p. 853-860 8 p.

Research output: Contribution to journalArticle

gadodiamide
Ferrosoferric Oxide
Glioma
Nanoparticles
Dexamethasone
14 Citations (Scopus)

Efficacy and MRI of rituximab and methotrexate treatment in a nude rat model of CNS lymphoma

Jahnke, K., Muldoon, L., Varallyay, C. G., Lewin, S. J., Brown, R. D., Kraemer, D., Soussain, C. & Neuwelt, E., Oct 2009, In : Neuro-Oncology. 11, 5, p. 503-513 11 p.

Research output: Contribution to journalArticle

Nude Rats
Methotrexate
Lymphoma
Tumor Burden
Gadolinium
2008
7 Citations (Scopus)

Biocompatible core-shell magnetic nanoparticles for cancer treatment

Sharma, A., Qiang, Y., Meyer, D., Souza, R., McConnaughoy, A., Muldoon, L. & Baer, D., 2008, In : Journal of Applied Physics. 103, 7, 07A308.

Research output: Contribution to journalArticle

cancer
nanoparticles
iron
magnetic moments
cells
64 Citations (Scopus)

Effect of N-acetylcysteine route of administration on chemoprotection against cisplatin-induced toxicity in rat models

Dickey, D. T., Muldoon, L., Doolittle, N., Peterson, D. R., Kraemer, D. & Neuwelt, E., Jul 2008, In : Cancer Chemotherapy and Pharmacology. 62, 2, p. 235-241 7 p.

Research output: Contribution to journalArticle

Acetylcysteine
Cisplatin
Toxicity
Rats
Blood
31 Citations (Scopus)

Intraarterial chemotherapy and osmotic blood-brain barrier disruption for patients with embryonal and germ cell tumors of the central nervous system

Jahnke, K., Kraemer, D., Knight, K., Fortin, D., Bell, S., Doolittle, N., Muldoon, L. & Neuwelt, E., Feb 1 2008, In : Cancer. 112, 3, p. 581-588 8 p.

Research output: Contribution to journalArticle

Nervous System Neoplasms
Germ Cell and Embryonal Neoplasms
Blood-Brain Barrier
Central Nervous System
Drug Therapy
17 Citations (Scopus)

N-Acetylcysteine Use to Prevent Contrast Medium-induced Nephropathy: Premature Phase III Trials

Stenstrom, D. A., Muldoon, L., Armijo-Medina, H., Watnick, S., Doolittle, N., Kaufman, J., Peterson, D. R., Bubalo, J. & Neuwelt, E., Mar 2008, In : Journal of Vascular and Interventional Radiology. 19, 3, p. 309-318 10 p.

Research output: Contribution to journalArticle

Acetylcysteine
Contrast Media
Pharmacology
Phase III Clinical Trials
Liver
2007
14 Citations (Scopus)

Characterization and magnetic resonance imaging of a rat model of human B-cell central nervous system lymphoma

Soussain, C., Muldoon, L., Varallyay, C., Jahnke, K., DePaula, L. & Neuwelf, E. A., Apr 15 2007, In : Clinical Cancer Research. 13, 8, p. 2504-2511 8 p.

Research output: Contribution to journalArticle

Lymphoma
B-Lymphocytes
Central Nervous System
Magnetic Resonance Imaging
Neoplasms
265 Citations (Scopus)

Chemotherapy delivery issues in central nervous system malignancy: A reality check

Muldoon, L., Soussain, C., Jahnke, K., Johanson, C., Siegal, T., Smith, Q. R., Hall, W. A., Hynynen, K., Senter, P. D., Peereboom, D. M. & Neuwelt, E., Jun 1 2007, In : Journal of Clinical Oncology. 25, 16, p. 2295-2305 11 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Central Nervous System
Drug Therapy
Neoplasms
Cerebrospinal Fluid
32 Citations (Scopus)

Delivery of chemotherapy and antibodies across the blood-brain barrier and the role of chemoprotection, in primary and metastatic brain tumors: Report of the eleventh annual blood-brain barrier consortium meeting

Doolittle, N., Peereboom, D. M., Christoforidis, G. A., Hall, W. A., Palmieri, D., Brock, P. R., Campbell, K. C. M., Dickey, D. T., Muldoon, L., O'Neill, B. P., Peterson, D. R., Pollock, B., Soussain, C., Smith, Q., Tyson, R. M. & Neuwelt, E., Jan 2007, In : Journal of Neuro-Oncology. 81, 1, p. 81-91 11 p.

Research output: Contribution to journalArticle

Annual Reports
Blood-Brain Barrier
Brain Neoplasms
Central Nervous System
Central Nervous System Diseases
48 Citations (Scopus)
Protamines
Magnetic resonance
Labeling
Leukocytes
Magnetic Resonance Imaging
25 Citations (Scopus)

Imaging and nanomedicine for diagnosis and therapy in the central nervous system: Report of the eleventh annual blood-brain barrier disruption consortium meeting

Muldoon, L., Tratnyek, P., Jacobs, P. M., Doolittle, N., Christoforidis, G. A., Frank, J. A., Lindau, M., Lockman, P. R., Manninger, S. P., Qiang, Y., Spence, A. M., Stupp, S. I., Zhang, M. & Neuwelt, E., Mar 2006, In : American Journal of Neuroradiology. 27, 3, p. 715-721 7 p.

Research output: Contribution to journalArticle

Nanomedicine
Annual Reports
Blood-Brain Barrier
Central Nervous System
Nanotechnology
15 Citations (Scopus)

Implications of the blood-brain barrier in primary central nervous system lymphoma.

Jahnke, K., Doolittle, N., Muldoon, L. & Neuwelt, E., 2006, In : Neurosurgical Focus. 21, 5

Research output: Contribution to journalArticle

Blood-Brain Barrier
Lymphoma
Central Nervous System
Brain
Drug Therapy
41 Citations (Scopus)

Osmotic blood-brain barrier disruption chemotherapy for diffuse pontine gliomas

Hall, W. A., Doolittle, N., Daman, M., Bruns, P. K., Muldoon, L., Fortin, D. & Neuwelt, E., May 2006, In : Journal of Neuro-Oncology. 77, 3, p. 279-284 6 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Glioma
Drug Therapy
Methotrexate
Carboplatin
2 Citations (Scopus)

The treatment of brain metastasis from breast cancer, role of blood-brain barrier disruption and early experience with trastuzumab

Tyson, R. M., Kraemer, D., Hunt, M. A., Muldoon, L., Orbay, P., Maron, L., Jahnke, K. & Neuwelt, E., Jan 2006, In : Therapy. 3, 1, p. 97-112 16 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Breast Neoplasms
Neoplasm Metastasis
Brain
Drug Therapy