Laura Heiser

Assistant Professor

  • 5534 Citations
  • 22 h-Index
20052019
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Research Output 2005 2019

  • 5534 Citations
  • 22 h-Index
  • 45 Article
  • 3 Comment/debate
  • 2 Conference contribution
  • 1 Short survey
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Article
2019

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Coleman, D. J., Gao, L., King, C. J., Schwartzman, J., Urrutia, J., Sehrawat, A., Tayou, J., Balter, A., Burchard, J., Chiotti, K. E., Derrick, D. S., Sun, D., Xia, Z., Heiser, L. & Alumkal, J., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Androgen Receptors
Castration
Prostatic Neoplasms
RNA Sequence Analysis
Neoplasms
1 Citation (Scopus)

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

Coleman, D. J., Gao, L., Schwartzman, J., Korkola, J., Sampson, D., Derrick, D. S., Urrutia, J., Balter, A., Burchard, J., King, C. J., Chiotti, K. E., Heiser, L. & Alumkal, J., Dec 1 2019, In : Scientific Reports. 9, 1, 3823.

Research output: Contribution to journalArticle

Open Access
Castration
Prostatic Neoplasms
Maintenance
Androgen Receptors
Cell Line

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Smith, R., Devlin, K., Kilburn, D., Gross, S., Sudar, D., Bucher, E., Nederlof, M., Dane, M., Gray, J. W., Heiser, L. & Korkola, J., May 21 2019, In : Journal of visualized experiments : JoVE. 147

Research output: Contribution to journalArticle

Microarrays
Assays
Proteins
Complex Mixtures
Phenotype
2018
16 Citations (Scopus)

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Sehrawat, A., Gao, L., Wang, Y., Bankhead, A., McWeeney, S., King, C. J., Schwartzman, J., Urrutia, J., Bisson, W. H., Coleman, D. J., Joshi, S. K., Kim, D. H., Sampson, D. A., Weinmann, S., Kallakury, B. V. S., Berry, D. L., Haque, R., Van Den Eeden, S. K., Sharma, S., Bearss, J. & 4 others, Beer, T. T., Thomas, G., Heiser, L. & Alumkal, J., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. E4179-E4188

Research output: Contribution to journalArticle

Gene Regulatory Networks
Neoplasm Genes
Lysine
Prostatic Neoplasms
Castration
6 Citations (Scopus)

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

Watson, S. S., Dane, M., Chin, K-Y., Tatarova, Z., Liu, M., Liby, T., Thompson, W., Smith, R., Nederlof, M., Bucher, E., Kilburn, D., Whitman, M., Sudar, D., Mills, G., Heiser, L., Jonas, O., Gray, J. & Korkola, J., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Breast Neoplasms
Ligands
Cell Line
Hepatocyte Growth Factor
2017
3 Citations (Scopus)

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Rahman, M., MacNeil, S. M., Jenkins, D. F., Shrestha, G., Wyatt, S. R., McQuerry, J. A., Piccolo, S. R., Heiser, L., Gray, J., Johnson, W. E. & Bild, A. H., Apr 26 2017, In : Genome Medicine. 9, 1, 40.

Research output: Contribution to journalArticle

Growth Factor Receptors
Breast Neoplasms
Phenotype
Pharmaceutical Preparations
Growth
18 Citations (Scopus)

Combating subclonal evolution of resistant cancer phenotypes

Brady, S. W., McQuerry, J. A., Qiao, Y., Piccolo, S. R., Shrestha, G., Jenkins, D. F., Layer, R. M., Pedersen, B. S., Miller, R. H., Esch, A., Selitsky, S. R., Parker, J. S., Anderson, L. A., Dalley, B. K., Factor, R. E., Reddy, C. B., Boltax, J. P., Li, D. Y., Moos, P. J., Gray, J. & 8 others, Heiser, L., Buys, S. S., Cohen, A. L., Johnson, W. E., Quinlan, A. R., Marth, G., Werner, T. L. & Bild, A. H., Dec 1 2017, In : Nature Communications. 8, 1, 1231.

Research output: Contribution to journalArticle

phenotype
Chemotherapy
cancer
drugs
Phenotype
9 Citations (Scopus)

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

Hill, S. M., Nesser, N. K., Johnson-Camacho, K., Jeffress, M., Johnson, A., Boniface, C., Spencer, S. E. F., Lu, Y., Heiser, L., Lawrence, Y., Pande, N. T., Korkola, J., Gray, J., Mills, G., Mukherjee, S. & Spellman, P., Jan 25 2017, In : Cell Systems. 4, 1, p. 73-83.e10

Research output: Contribution to journalArticle

Phosphoproteins
Protein Array Analysis
Receptor Protein-Tyrosine Kinases
Proteins
Phosphotransferases
21 Citations (Scopus)

HER2 reactivation through acquisition of the HER2 L755S mutation as a mechanism of acquired resistance to HER2-targeted therapy in HER2+ breast cancer

Xu, X., De Angelis, C., Burke, K. A., Nardone, A., Hu, H., Qin, L., Veeraraghavan, J., Sethunath, V., Heiser, L., Wang, N., Ng, C. K. Y., Chen, E. S., Renwick, A., Wang, T., Nanda, S., Shea, M., Mitchell, T., Rajendran, M., Waters, I., Zabransky, D. J. & 14 others, Scott, K. L., Gutierrez, C., Nagi, C., Geyer, F. C., Chamness, G. C., Park, B. H., Shaw, C. A., Hilsenbeck, S. G., Rimawi, M. F., Gray, J., Weigelt, B., Reis-Filho, J. S., Osborne, C. K. & Schiff, R., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5123-5134 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Mutation
Cell Line
Small Interfering RNA
Therapeutics
2 Citations (Scopus)

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer

King, C. J., Woodward, J., Schwartzman, J., Coleman, D. J., Lisac, R., Wang, N. J., Hook, K. V., Gao, L., Urrutia, J., Dane, M. A., Heiser, L. & Alumkal, J., Jan 1 2017, In : Oncotarget. 8, 67, p. 111084-111095 12 p.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Neoplasms
Drug Resistance
Genes
9 Citations (Scopus)

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Farrell, A., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L., Morton, J. P., Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D. & 5 others, Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. & Sears, R., Dec 1 2017, In : Nature Communications. 8, 1, 1728.

Research output: Contribution to journalArticle

Synaptophysin
plastic properties
markers
Plasticity
Tumors
5 Citations (Scopus)

Pathway-enriched gene signature associated with 53BP1 response to PARP inhibition in triple-negative breast cancer

Hassan, S., Esch, A., Liby, T., Gray, J. & Heiser, L., Dec 1 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2892-2901 10 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Genes
DNA Damage
Biomarkers
Breast Neoplasms
3 Citations (Scopus)

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics

Hafner, M., Heiser, L., Williams, E. H., Niepel, M., Wang, N. J., Korkola, J., Gray, J. & Sorger, P. K., Nov 7 2017, In : Scientific data. 4, 170166.

Research output: Contribution to journalArticle

Breast Cancer
quantification
Quantification
Cancer
Drugs
58 Citations (Scopus)

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C. & 87 others, Vasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J. E., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L., Gray, J., Korkola, J., Mills, G., LaBarge, M., Feiler, H., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 1 2017, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

Cataloging
Libraries
Inborn Genetic Diseases
Molecular Imaging
Neurodegenerative Diseases
2016
7 Citations (Scopus)

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor

Coleman, D. J., Van Hook, K., King, C. J., Schwartzman, J., Lisac, R., Urrutia, J., Sehrawat, A., Woodward, J., Wang, N. J., Gulati, R., Thomas, G., Beer, T. T., Gleave, M., Korkola, J., Gao, L., Heiser, L. & Alumkal, J., 2016, In : Oncotarget. 7, 26, p. 40690 1 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Castration
Prostatic Neoplasms
MDV 3100
32 Citations (Scopus)

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Fu, X., Jeselsohn, R., Pereira, R., Hollingsworth, E. F., Creighton, C. J., Li, F., Shea, M., Nardone, A., De Angelis, C., Heiser, L., Anur, P., Wang, N., Grasso, C. S., Spellman, P., Griffith, O. L., Tsimelzon, A., Gutierrez, C., Huang, S., Edwards, D. P., Trivedi, M. V. & 7 others, Rimawi, M. F., Lopez-Terrada, D., Hilsenbeck, S. G., Gray, J., Brown, M., Osborne, C. K. & Schiff, R., Oct 25 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 43, p. E6600-E6609

Research output: Contribution to journalArticle

Interleukin-8
Transcriptome
Estrogen Receptors
Breast Neoplasms
Hepatocyte Nuclear Factor 3-alpha
5 Citations (Scopus)

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Hu, Z., Mao, J. H., Curtis, C., Huang, G., Gu, S., Heiser, L., Lenburg, M. E., Korkola, J., Bayani, N., Samarajiwa, S., Seoane, J. A., Dane, M., Esch, A., Feiler, H., Wang, N. J., Hardwicke, M. A., Laquerre, S., Jackson, J., Wood, K., Weber, B. & 5 others, Spellman, P., Aparicio, S., Wooster, R., Caldas, C. & Gray, J., Jul 1 2016, In : Breast Cancer Research. 18, 1, 70.

Research output: Contribution to journalArticle

Spindle Apparatus
Gene Regulatory Networks
Up-Regulation
Genome
Breast Neoplasms
76 Citations (Scopus)

Inferring causal molecular networks: Empirical assessment through a community-based effort

Hill, S. M., Heiser, L., Cokelaer, T., Unger, M., Nesser, N. K., Carlin, D. E., Zhang, Y., Sokolov, A., Paull, E. O., Wong, C. K., Graim, K., Bivol, A., Wang, H., Zhu, F., Afsari, B., Danilova, L. V., Favorov, A. V., Lee, W. S., Taylor, D., Hu, C. W. & 18 others, Long, B. L., Noren, D. P., Bisberg, A. J., Mills, G., Gray, J., Kellen, M., Norman, T., Friend, S., Qutub, A. A., Fertig, E. J., Guan, Y., Song, M., Stuart, J. M., Spellman, P., Koeppl, H., Stolovitzky, G., Saez-Rodriguez, J. & Mukherjee, S., Mar 30 2016, In : Nature Methods. 13, 4, p. 310-318 9 p.

Research output: Contribution to journalArticle

Phosphoproteins
Learning
Nonlinear Dynamics
Computer Simulation
Visualization
11 Citations (Scopus)

PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder

Brown, A., Patel, S., Ward, C., Lorenz, A., Ortiz, M., DuRoss, A., Wieghardt, F., Esch, A., Otten, E. G., Heiser, L., Korolchuk, V. I., Sun, C., Sarkar, S. & Sahay, G., Aug 30 2016, In : Scientific Reports. 6, 31750.

Research output: Contribution to journalArticle

Type C Niemann-Pick Disease
Micelles
Cholesterol
Lipids
Cyclodextrins
63 Citations (Scopus)

Tumor-derived cell lines as molecular models of cancer pharmacogenomics

Goodspeed, A., Heiser, L., Gray, J. & Costello, J. C., Jan 1 2016, In : Molecular Cancer Research. 14, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Molecular Models
Pharmacogenetics
Tumor Cell Line
Neoplasms
Cell Line
2015
4 Citations (Scopus)

A network-based model of oncogenic collaboration for prediction of drug sensitivity

Laderas, T. G., Heiser, L. & Sonmez, M. K., 2015, In : Frontiers in Genetics. 6, DEC, 00341.

Research output: Contribution to journalArticle

Oncogenes
Pharmaceutical Preparations
Mutation
Precision Medicine
Breast Neoplasms
10 Citations (Scopus)

Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer

Korkola, J., Collisson, E. A., Heiser, L., Oates, C., Bayani, N., Itani, S., Esch, A., Thompson, W., Griffith, O. L., Wang, N. J., Kuo, W. L., Cooper, B., Billig, J., Ziyad, S., Hung, J. L., Feiler, H., Lu, Y., Mills, G., Spellman, P., Tomlin, C. & 3 others, Mukherjee, S., Gray, J. & Jakkula, L., Jul 16 2015, In : PLoS One. 10, 7, e0133219.

Research output: Contribution to journalArticle

phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
breast neoplasms
Breast Neoplasms
mutation
2 Citations (Scopus)

Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]

Daemen, A., Griffith, O. L., Heiser, L., Wang, N. J., Enache, O. M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J., Griffith, M., Hur, J. S., Huh, N., Chung, J., Cope, L., Fackler, M. J., Umbricht, C., Sukumar, S., Seth, P., Sukhatme, V. P., Jakkula, L. R. & 7 others, Lu, Y., Mills, G., Cho, R. J., Collisson, E. A., van't Veer, L. J., Spellman, P. & Gray, J., May 12 2015, In : Genome Biology. 16, 1, 95.

Research output: Contribution to journalArticle

breast neoplasms
cancer
genome
Genome
Breast Neoplasms
12 Citations (Scopus)

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

Lue, H. W., Cole, B., Rao, S. A. M., Podolak, J., Van Gaest, A., King, C., Eide, C. A., Wilmot, B., Xue, C., Spellman, P., Heiser, L., Tyner, J. & Thomas, G., 2015, In : Oncotarget. 6, 42, p. 44675-44687 13 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Cell Survival
Cell Proliferation
Organ Size
38 Citations (Scopus)

Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with Anti-HER2 therapy

Giuliano, M., Hu, H., Wang, Y. C., Fu, X., Nardone, A., Herrera, S., Mao, S., Contreras, A., Gutierrez, C., Wang, T., Hilsenbeck, S. G., Angelis, C. D., Wang, N. J., Heiser, L., Gray, J., Lopez-Tarruella, S., Pavlick, A. C., Trivedi, M. V., Chamness, G. C., Chang, J. C. & 3 others, Osborne, C. K., Rimawi, M. F. & Schiff, R., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 3995-4003 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Cell Survival
Up-Regulation
Breast Neoplasms
Therapeutics
2014
104 Citations (Scopus)

A community computational challenge to predict the activity of pairs of compounds

Cellworks Group & NCI DREAM Community, Dec 1 2014, In : Nature Biotechnology. 32, 12, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

Computer Simulation
Drug Combinations
Transcriptome
Gene expression
Screening
222 Citations (Scopus)

A community effort to assess and improve drug sensitivity prediction algorithms

NCI DREAM Community, Dec 1 2014, In : Nature Biotechnology. 32, 12, p. 1202-1212 11 p.

Research output: Contribution to journalArticle

Reverse engineering
Microarrays
Gene expression
Pharmaceutical Preparations
Medicine
38 Citations (Scopus)

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase

Fu, X., Creighton, C. J., Biswal, N. C., Kumar, V., Shea, M., Herrera, S., Contreras, A., Gutierrez, C., Wang, T., Nanda, S., Giuliano, M., Morrison, G., Nardone, A., Karlin, K. L., Westbrook, T. F., Heiser, L., Anur, P., Spellman, P., Guichard, S. M., Smith, P. D. & 10 others, Davies, B. R., Klinowska, T., Lee, A. V., Mills, G., Rimawi, M. F., Hilsenbeck, S. G., Gray, J., Joshi, A., Osborne, C. K. & Schiff, R., Sep 11 2014, In : Breast Cancer Research. 16, 5, 430.

Research output: Contribution to journalArticle

TOR Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt
Mitogen-Activated Protein Kinase Kinases
Phosphatidylinositol 3-Kinase
Phosphoric Monoester Hydrolases
2013
10 Citations (Scopus)

A robust prognostic signature for hormone-positive node-negative breast cancer

Griffith, O. L., Pepin, F., Enache, O. M., Heiser, L., Collisson, E. A., Spellman, P. & Gray, J., Oct 11 2013, In : Genome Medicine. 5, 10, 92.

Research output: Contribution to journalArticle

Hormones
Breast Neoplasms
Recurrence
Genes
Survival Analysis
131 Citations (Scopus)

Metrics other than potency reveal systematic variation in responses to cancer drugs

Fallahi-Sichani, M., Honarnejad, S., Heiser, L., Gray, J. & Sorger, P. K., Nov 2013, In : Nature Chemical Biology. 9, 11, p. 708-714 7 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Neoplasms
Single-Cell Analysis
Drug Delivery Systems
Phosphatidylinositol 3-Kinases
122 Citations (Scopus)

Modeling precision treatment of breast cancer.

Daemen, A., Griffith, O. L., Heiser, L., Wang, N. J., Enache, O. M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J., Griffith, M., Hur, J. S., Huh, N., Chung, J., Cope, L., Fackler, M. J., Umbricht, C., Sukumar, S., Seth, P., Sukhatme, V. P., Jakkula, L. R. & 7 others, Lu, Y., Mills, G., Cho, R. J., Collisson, E. A., van't Veer, L. J., Spellman, P. & Gray, J., 2013, In : Genome Biology. 14, 10

Research output: Contribution to journalArticle

breast neoplasms
cancer
Breast Neoplasms
therapeutics
modeling
2012
130 Citations (Scopus)

A Central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma

Collisson, E. A., Trejo, C. L., Silva, J. M., Gu, S., Korkola, J., Heiser, L., Charles, R. P., Rabinovich, B. A., Hann, B., Dankort, D., Spellman, P., Phillips, W. A., Gray, J. & McMahon, M., Aug 2012, In : Cancer Discovery. 2, 8, p. 685-693 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Maintenance
Cell Line
Mutation
1-Phosphatidylinositol 4-Kinase
16 Citations (Scopus)

ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells

Ordinario, E., Han, H. J., Furuta, S., Heiser, L., Jakkula, L. R., Rodier, F., Spellman, P., Campisi, J., Gray, J., Bissell, M. J., Kohwi, Y. & Kohwi-Shigematsu, T., Dec 10 2012, In : PLoS One. 7, 12, e51786.

Research output: Contribution to journalArticle

Automatic teller machines
breasts
Breast
epithelial cells
Epithelial Cells
59 Citations (Scopus)

Bayesian Inference of Signaling Network Topology in a Cancer Cell Line

Hill, S. M., Lu, Y., Molina, J., Heiser, L., Spellman, P., Speed, T. P., Gray, J., Mills, G. & Mukherjee, S., Nov 2012, In : Bioinformatics. 28, 21, p. 2804-2810 7 p.

Research output: Contribution to journalArticle

Bayesian inference
Network Topology
Cancer
Cells
Topology
252 Citations (Scopus)

Subtype and pathway specific responses to anticancer compounds in breast cancer

Heiser, L., Sadanandam, A., Kuo, W. L., Benz, S. C., Goldstein, T. C., Ng, S., Gibb, W. J., Wang, N. J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J. I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J., Durinck, S., Pepin, F., Guan, Y. & 23 others, Purdom, E., Neuvial, P., Bengtsson, H., Wood, K. W., Smith, P. G., Vassilev, L. T., Hennessy, B. T., Greshock, J., Bachman, K. E., Hardwicke, M. A., Park, J. W., Marton, L. J., Wolf, D. M., Collisson, E. A., Neve, R. M., Mills, G., Speed, T. P., Feiler, H., Richard, F. W., Haussler, D., Stuart, J. M., Gray, J. & Spellman, P., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2724-2729 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Line
Pharmaceutical Preparations
Therapeutics
Neoplasms
2011
3495 Citations (Scopus)

Integrated genomic analyses of ovarian carcinoma

Bell, D., Berchuck, A., Birrer, M., Chien, J., Cramer, D. W., Dao, F., Dhir, R., Disaia, P., Gabra, H., Glenn, P., Godwin, A. K., Gross, J., Hartmann, L., Huang, M., Huntsman, D. G., Iacocca, M., Imielinski, M., Kalloger, S., Karlan, B. Y., Levine, D. A. & 277 others, Mills, G., Morrison, C., Mutch, D., Olvera, N., Orsulic, S., Park, K., Petrelli, N., Rabeno, B., Rader, J. S., Sikic, B. I., Smith-Mccune, K., Sood, A. K., Bowtell, D., Penny, R., Testa, J. R., Chang, K., Dinh, H. H., Drummond, J. A., Fowler, G., Gunaratne, P., Hawes, A. C., Kovar, C. L., Lewis, L. R., Morgan, M. B., Newsham, I. F., Santibanez, J., Reid, J. G., Trevino, L. R., Wu, Y. Q., Wang, M., Muzny, D. M., Wheeler, D. A., Gibbs, R. A., Getz, G., Lawrence, M. S., Cibulskis, K., Sivachenko, A. Y., Sougnez, C., Voet, D., Wilkinson, J., Bloom, T., Ardlie, K., Fennell, T., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., Koboldt, D. C., McLellan, M. D., Wylie, T., Walker, J., O'Laughlin, M., Dooling, D. J., Fulton, L., Abbott, R., Dees, N. D., Zhang, Q., Kandoth, C., Wendl, M., Schierding, W., Shen, D., Harris, C. C., Schmidt, H., Kalicki, J., Delehaunty, K. D., Fronick, C. C., Demeter, R., Cook, L., Wallis, J. W., Lin, L., Magrini, V. J., Hodges, J. S., Eldred, J. M., Smith, S. M., Pohl, C. S., Vandin, F., Raphael, B. J., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Meyerson, M., Winckler, W., Getz, G., Verhaak, R. G. W., Carter, S. L., Mermel, C. H., Saksena, G., Nguyen, H., Onofrio, R. C., Lawrence, M. S., Hubbard, D., Gupta, S., Crenshaw, A., Ramos, A. H., Ardlie, K., Chin, L., Protopopov, A., Zhang, J., Kim, T. M., Perna, I., Xiao, Y., Zhang, H., Ren, G., Sathiamoorthy, N., Park, R. W., Lee, E., Park, P. J., Kucherlapati, R., Absher, D. M., Waite, L., Sherlock, G., Brooks, J. D., Li, J. Z., Xu, J., Myers, R. M., Laird, P. W., Cope, L., Herman, J. G., Shen, H., Weisenberger, D. J., Noushmehr, H., Pan, F., Triche, T., Berman, B. P., Spellman, P., Buckley, J., Baylin, S. B., Spellman, P. T., Purdom, E., Neuvial, P., Bengtsson, H., Jakkula, L. R., Durinck, S., Han, J., Dorton, S., Marr, H., Choi, Y. G., Wang, V., Wang, N. J., Feiler, H., Conboy, J. G., Gray, J., Feiler, H. S., Speed, T. P., Gray, J. W., Levine, D. A., Socci, N. D., Liang, Y., Taylor, B. S., Schultz, N., Borsu, L., Lash, A. E., Brennan, C., Viale, A., Sander, C., Ladanyi, M., Hoadley, K. A., Meng, S., Du, Y., Shi, Y., Li, L., Turman, Y. J., Zang, D., Helms, E. B., Balu, S., Zhou, X., Wu, J., Topal, M. D., Hayes, D. N., Perou, C. M., Getz, G., Voet, D., Saksena, G., Zhang, J., Zhang, H., Korkola, J., Heiser, L., Cibulskis, K., Hu, Z., Sivachenko, A., Jing, R., Park, R. W., Liu, Y., Park, P. J., Noble, M., Chin, L., Carter, H., Kim, D., Karchin, R., Spellman, P. T., Purdom, E., Neuvial, P., Bengtsson, H., Durinck, S., Han, J., Korkola, J. E., Heiser, L. M., Cho, R. J., Hu, Z., Parvin, B., Speed, T. P., Gray, J. W., Schultz, N., Cerami, E., Taylor, B. S., Olshen, A., Reva, B., Antipin, Y., Shen, R., Mankoo, P., Sheridan, R., Ciriello, G., Chang, W. K., Bernanke, J. A., Borsu, L., Levine, D. A., Ladanyi, M., Sander, C., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Sanborn, J. Z., Vaske, C. J., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Hoadley, K. A., Du, Y., Balu, S., Hayes, D. N., Perou, C. M., Wilkerson, M. D., Zhang, N., Akbani, R., Baggerly, K. A., Yung, W. K., Mills, G. B., Weinstein, J. N., Penny, R., Shelton, T., Grimm, D., Hatfield, M., Morris, S., Yena, P., Rhodes, P., Sherman, M., Paulauskis, J., Millis, S., Kahn, A., Greene, J. M., Sfeir, R., Jensen, M. A., Chen, J., Whitmore, J., Alonso, S., Jordan, J., Chu, A., Zhang, J., Barker, A., Compton, C., Eley, G., Ferguson, M., Fielding, P., Gerhard, D. S., Myles, R., Schaefer, C., Mills Shaw, K. R., Vaught, J., Vockley, J. B., Good, P. J., Guyer, M. S., Ozenberger, B., Peterson, J. & Thomson, E., Jun 30 2011, In : Nature. 474, 7353, p. 609-615 7 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Neoplasms
MicroRNAs
Methylation
2009
24 Citations (Scopus)

A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047

Kuo, W. L., Das, D., Ziyad, S., Bhattacharya, S., Gibb, W. J., Heiser, L., Sadanandam, A., Fontenay, G. V., Hu, Z., Wang, N. J., Bayani, N., Feiler, H., Neve, R. M., Wyrobek, A. J., Spellman, P., Marton, L. J. & Gray, J., Dec 14 2009, In : BMC Medicine. 7, 77.

Research output: Contribution to journalArticle

Polyamines
Systems Analysis
Breast Neoplasms
Cell Line
Breast
263 Citations (Scopus)

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

Mirzoeva, O. K., Das, D., Heiser, L., Bhattacharya, S., Siwak, D., Gendelman, R., Bayani, N., Wang, N. J., Neve, R. M., Guan, Y., Hu, Z., Knight, Z., Feiler, H., Gascard, P., Parvin, B., Spellman, P., Shokat, K. M., Wyrobek, A. J., Bissell, M. J., McCormick, F. & 4 others, Kuo, W. L., Mills, G., Gray, J. & Korn, W. M., Jan 15 2009, In : Cancer Research. 69, 2, p. 565-572 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Phosphotransferases
Breast Neoplasms
51 Citations (Scopus)

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

Heiser, L., Wang, N. J., Talcott, C. L., Laderoute, K. R., Knapp, M., Guan, Y., Hu, Z., Ziyad, S., Weber, B. L., Laquerre, S., Jackson, J. R., Wooster, R. F., Kuo, W., Gray, J. & Spellman, P., Mar 25 2009, In : Genome Biology. 10, 3, R31.

Research output: Contribution to journalArticle

breast neoplasms
cancer
cell lines
Breast Neoplasms
Cell Line
2007
46 Citations (Scopus)

Analysis of molecular inversion probe performance for allele copy number determination

Wang, Y., Moorhead, M., Karlin-Neumann, G., Wang, N. J., Ireland, J., Lin, S., Chen, C., Heiser, L., Chin, K-Y., Esserman, L., Gray, J., Spellman, P. & Faham, M., Nov 20 2007, In : Genome Biology. 8, 11, R246.

Research output: Contribution to journalArticle

Molecular Probes
allele
Alleles
probe
alleles
22 Citations (Scopus)

Dynamic circuitry for updating spatial representations. III. From neurons to behavior

Berman, R. A., Heiser, L., Dunn, C. A., Saunders, R. C. & Colby, C. L., Jul 2007, In : Journal of Neurophysiology. 98, 1, p. 105-121 17 p.

Research output: Contribution to journalArticle

Split-Brain Procedure
Haplorhini
Neurons
Saccades
Spatial Behavior
2006
64 Citations (Scopus)

Spatial updating in area LIP is independent of saccade direction

Heiser, L. & Colby, C. L., May 2006, In : Journal of Neurophysiology. 95, 5, p. 2751-2767 17 p.

Research output: Contribution to journalArticle

Saccades
Neurons
Access to Information
Visual Fields
Eye Movements
2005
23 Citations (Scopus)

Corollary discharge and spatial updating: When the brain is split, is space still unified?

Colby, C. L., Berman, R. A., Heiser, L. & Saunders, R. C., 2005, In : Progress in Brain Research. 149, p. 187-205 19 p.

Research output: Contribution to journalArticle

Saccades
Haplorhini
Neurons
Brain
Split-Brain Procedure
24 Citations (Scopus)

Dynamic circuitry for updating spatial representations. I. Behavioral evidence for interhemispheric transfer in the split-brain macaque

Berman, R. A., Heiser, L., Saunders, R. C. & Colby, C. L., Nov 2005, In : Journal of Neurophysiology. 94, 5, p. 3228-3248 21 p.

Research output: Contribution to journalArticle

Split-Brain Procedure
Macaca
Haplorhini
Saccades
27 Citations (Scopus)

Dynamic circuitry for updating spatial representations. II. Physiological evidence for interhemispheric transfer in area LIP of the split-brain macaque

Heiser, L., Berman, R. A., Saunders, R. C. & Colby, C. L., Nov 2005, In : Journal of Neurophysiology. 94, 5, p. 3249-3258 10 p.

Research output: Contribution to journalArticle

Split-Brain Procedure
Macaca
Eye Movements
Neurons
Haplorhini