Research Output per year
Research Output 2005 2019
Annot: A Django-based sample, reagent, and experiment metadata tracking system
Bucher, E., Claunch, C. J., Hee, D., Smith, R. L., Devlin, K., Thompson, W., Korkola, J. E. & Heiser, L. M., Nov 1 2019, In : BMC bioinformatics. 20, 1, 542.Research output: Contribution to journal › Article
BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer
Coleman, D. J., Gao, L., King, C. J., Schwartzman, J., Urrutia, J., Sehrawat, A., Tayou, J., Balter, A., Burchard, J., Chiotti, K. E., Derrick, D. S., Sun, D., Xia, Z., Heiser, L. & Alumkal, J., Jan 1 2019, In : Oncogene.Research output: Contribution to journal › Article
Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer
Coleman, D. J., Gao, L., Schwartzman, J., Korkola, J., Sampson, D., Derrick, D. S., Urrutia, J., Balter, A., Burchard, J., King, C. J., Chiotti, K. E., Heiser, L. & Alumkal, J., Dec 1 2019, In : Scientific Reports. 9, 1, 3823.Research output: Contribution to journal › Article
Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer
Sethunath, V., Hu, H., De Angelis, C., Veeraraghavan, J., Qin, L., Wang, N., Simon, L. M., Wang, T., Fu, X., Nardone, A., Pereira, R., Nanda, S., Griffith, O. L., Tsimelzon, A., Shaw, C., Chamness, G. C., Reis-Filho, J. S., Weigelt, B., Heiser, L. M., Hilsenbeck, S. G. & 5 others, , Nov 1 2019, In : Molecular cancer research : MCR. 17, 11, p. 2318-2330 13 p.Research output: Contribution to journal › Article
Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer
Smith, R., Devlin, K., Kilburn, D., Gross, S., Sudar, D., Bucher, E., Nederlof, M., Dane, M., Gray, J. W., Heiser, L. & Korkola, J., May 21 2019, In : Journal of visualized experiments : JoVE. 147Research output: Contribution to journal › Article
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
Sehrawat, A., Gao, L., Wang, Y., Bankhead, A., McWeeney, S., King, C. J., Schwartzman, J., Urrutia, J., Bisson, W. H., Coleman, D. J., Joshi, S. K., Kim, D. H., Sampson, D. A., Weinmann, S., Kallakury, B. V. S., Berry, D. L., Haque, R., Van Den Eeden, S. K., Sharma, S., Bearss, J. & 4 others, , May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. E4179-E4188Research output: Contribution to journal › Article
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
Watson, S. S., Dane, M., Chin, K-Y., Tatarova, Z., Liu, M., Liby, T., Thompson, W., Smith, R., Nederlof, M., Bucher, E., Kilburn, D., Whitman, M., Sudar, D., Mills, G., Heiser, L., Jonas, O., Gray, J. & Korkola, J., Jan 1 2018, (Accepted/In press) In : Cell Systems.Research output: Contribution to journal › Article
Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes
Rahman, M., MacNeil, S. M., Jenkins, D. F., Shrestha, G., Wyatt, S. R., McQuerry, J. A., Piccolo, S. R., Heiser, L., Gray, J., Johnson, W. E. & Bild, A. H., Apr 26 2017, In : Genome Medicine. 9, 1, 40.Research output: Contribution to journal › Article
Combating subclonal evolution of resistant cancer phenotypes
Brady, S. W., McQuerry, J. A., Qiao, Y., Piccolo, S. R., Shrestha, G., Jenkins, D. F., Layer, R. M., Pedersen, B. S., Miller, R. H., Esch, A., Selitsky, S. R., Parker, J. S., Anderson, L. A., Dalley, B. K., Factor, R. E., Reddy, C. B., Boltax, J. P., Li, D. Y., Moos, P. J., Gray, J. & 8 others, , Dec 1 2017, In : Nature Communications. 8, 1, 1231.Research output: Contribution to journal › Article
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
Hill, S. M., Nesser, N. K., Johnson-Camacho, K., Jeffress, M., Johnson, A., Boniface, C., Spencer, S. E. F., Lu, Y., Heiser, L., Lawrence, Y., Pande, N. T., Korkola, J., Gray, J., Mills, G., Mukherjee, S. & Spellman, P., Jan 25 2017, In : Cell Systems. 4, 1, p. 73-83.e10Research output: Contribution to journal › Article
HER2 reactivation through acquisition of the HER2 L755S mutation as a mechanism of acquired resistance to HER2-targeted therapy in HER2+ breast cancer
Xu, X., De Angelis, C., Burke, K. A., Nardone, A., Hu, H., Qin, L., Veeraraghavan, J., Sethunath, V., Heiser, L., Wang, N., Ng, C. K. Y., Chen, E. S., Renwick, A., Wang, T., Nanda, S., Shea, M., Mitchell, T., Rajendran, M., Waters, I., Zabransky, D. J. & 14 others, , Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5123-5134 12 p.Research output: Contribution to journal › Article
Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer
King, C. J., Woodward, J., Schwartzman, J., Coleman, D. J., Lisac, R., Wang, N. J., Hook, K. V., Gao, L., Urrutia, J., Dane, M. A., Heiser, L. & Alumkal, J., Jan 1 2017, In : Oncotarget. 8, 67, p. 111084-111095 12 p.Research output: Contribution to journal › Article
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
Farrell, A., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L., Morton, J. P., Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D. & 5 others, , Dec 1 2017, In : Nature Communications. 8, 1, 1728.Research output: Contribution to journal › Article
Pathway-enriched gene signature associated with 53BP1 response to PARP inhibition in triple-negative breast cancer
Hassan, S., Esch, A., Liby, T., Gray, J. & Heiser, L., Dec 1 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2892-2901 10 p.Research output: Contribution to journal › Article
Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics
Hafner, M., Heiser, L., Williams, E. H., Niepel, M., Wang, N. J., Korkola, J., Gray, J. & Sorger, P. K., Nov 7 2017, In : Scientific data. 4, 170166.Research output: Contribution to journal › Article
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C. & 87 others, , Jan 1 2017, (Accepted/In press) In : Cell Systems.Research output: Contribution to journal › Article
Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor
Coleman, D. J., Van Hook, K., King, C. J., Schwartzman, J., Lisac, R., Urrutia, J., Sehrawat, A., Woodward, J., Wang, N. J., Gulati, R., Thomas, G., Beer, T. T., Gleave, M., Korkola, J., Gao, L., Heiser, L. & Alumkal, J., 2016, In : Oncotarget. 7, 26, p. 40690 1 p.Research output: Contribution to journal › Article
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
Fu, X., Jeselsohn, R., Pereira, R., Hollingsworth, E. F., Creighton, C. J., Li, F., Shea, M., Nardone, A., De Angelis, C., Heiser, L., Anur, P., Wang, N., Grasso, C. S., Spellman, P., Griffith, O. L., Tsimelzon, A., Gutierrez, C., Huang, S., Edwards, D. P., Trivedi, M. V. & 7 others, , Oct 25 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 43, p. E6600-E6609Research output: Contribution to journal › Article
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer
Hu, Z., Mao, J. H., Curtis, C., Huang, G., Gu, S., Heiser, L., Lenburg, M. E., Korkola, J., Bayani, N., Samarajiwa, S., Seoane, J. A., Dane, M., Esch, A., Feiler, H., Wang, N. J., Hardwicke, M. A., Laquerre, S., Jackson, J., Wood, K., Weber, B. & 5 others, , Jul 1 2016, In : Breast Cancer Research. 18, 1, 70.Research output: Contribution to journal › Article
Inferring causal molecular networks: Empirical assessment through a community-based effort
Hill, S. M., Heiser, L., Cokelaer, T., Unger, M., Nesser, N. K., Carlin, D. E., Zhang, Y., Sokolov, A., Paull, E. O., Wong, C. K., Graim, K., Bivol, A., Wang, H., Zhu, F., Afsari, B., Danilova, L. V., Favorov, A. V., Lee, W. S., Taylor, D., Hu, C. W. & 18 others, , Mar 30 2016, In : Nature Methods. 13, 4, p. 310-318 9 p.Research output: Contribution to journal › Article
PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder
Brown, A., Patel, S., Ward, C., Lorenz, A., Ortiz, M., DuRoss, A., Wieghardt, F., Esch, A., Otten, E. G., Heiser, L., Korolchuk, V. I., Sun, C., Sarkar, S. & Sahay, G., Aug 30 2016, In : Scientific Reports. 6, 31750.Research output: Contribution to journal › Article
Tumor-derived cell lines as molecular models of cancer pharmacogenomics
Goodspeed, A., Heiser, L., Gray, J. & Costello, J. C., Jan 1 2016, In : Molecular Cancer Research. 14, 1, p. 3-13 11 p.Research output: Contribution to journal › Article
A network-based model of oncogenic collaboration for prediction of drug sensitivity
Laderas, T. G., Heiser, L. & Sonmez, M. K., 2015, In : Frontiers in Genetics. 6, DEC, 00341.Research output: Contribution to journal › Article
Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer
Korkola, J., Collisson, E. A., Heiser, L., Oates, C., Bayani, N., Itani, S., Esch, A., Thompson, W., Griffith, O. L., Wang, N. J., Kuo, W. L., Cooper, B., Billig, J., Ziyad, S., Hung, J. L., Feiler, H., Lu, Y., Mills, G., Spellman, P., Tomlin, C. & 3 others, , Jul 16 2015, In : PLoS One. 10, 7, e0133219.Research output: Contribution to journal › Article
Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]
Daemen, A., Griffith, O. L., Heiser, L., Wang, N. J., Enache, O. M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J., Griffith, M., Hur, J. S., Huh, N., Chung, J., Cope, L., Fackler, M. J., Umbricht, C., Sukumar, S., Seth, P., Sukhatme, V. P., Jakkula, L. R. & 7 others, , May 12 2015, In : Genome Biology. 16, 1, 95.Research output: Contribution to journal › Article
Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma
Lue, H. W., Cole, B., Rao, S. A. M., Podolak, J., Van Gaest, A., King, C., Eide, C. A., Wilmot, B., Xue, C., Spellman, P., Heiser, L., Tyner, J. & Thomas, G., 2015, In : Oncotarget. 6, 42, p. 44675-44687 13 p.Research output: Contribution to journal › Article
Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with Anti-HER2 therapy
Giuliano, M., Hu, H., Wang, Y. C., Fu, X., Nardone, A., Herrera, S., Mao, S., Contreras, A., Gutierrez, C., Wang, T., Hilsenbeck, S. G., Angelis, C. D., Wang, N. J., Heiser, L., Gray, J., Lopez-Tarruella, S., Pavlick, A. C., Trivedi, M. V., Chamness, G. C., Chang, J. C. & 3 others, , Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 3995-4003 9 p.Research output: Contribution to journal › Article
A community computational challenge to predict the activity of pairs of compounds
Cellworks Group & NCI DREAM Community, Dec 1 2014, In : Nature Biotechnology. 32, 12, p. 1213-1222 10 p.Research output: Contribution to journal › Article
A community effort to assess and improve drug sensitivity prediction algorithms
NCI DREAM Community, Dec 1 2014, In : Nature Biotechnology. 32, 12, p. 1202-1212 11 p.Research output: Contribution to journal › Article
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase
Fu, X., Creighton, C. J., Biswal, N. C., Kumar, V., Shea, M., Herrera, S., Contreras, A., Gutierrez, C., Wang, T., Nanda, S., Giuliano, M., Morrison, G., Nardone, A., Karlin, K. L., Westbrook, T. F., Heiser, L., Anur, P., Spellman, P., Guichard, S. M., Smith, P. D. & 10 others, , Sep 11 2014, In : Breast Cancer Research. 16, 5, 430.Research output: Contribution to journal › Article
A robust prognostic signature for hormone-positive node-negative breast cancer
Griffith, O. L., Pepin, F., Enache, O. M., Heiser, L., Collisson, E. A., Spellman, P. & Gray, J., Oct 11 2013, In : Genome Medicine. 5, 10, 92.Research output: Contribution to journal › Article
Metrics other than potency reveal systematic variation in responses to cancer drugs
Fallahi-Sichani, M., Honarnejad, S., Heiser, L., Gray, J. & Sorger, P. K., Nov 2013, In : Nature Chemical Biology. 9, 11, p. 708-714 7 p.Research output: Contribution to journal › Article
Modeling precision treatment of breast cancer.
Daemen, A., Griffith, O. L., Heiser, L., Wang, N. J., Enache, O. M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J., Griffith, M., Hur, J. S., Huh, N., Chung, J., Cope, L., Fackler, M. J., Umbricht, C., Sukumar, S., Seth, P., Sukhatme, V. P., Jakkula, L. R. & 7 others, , 2013, In : Genome Biology. 14, 10Research output: Contribution to journal › Article
A Central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma
Collisson, E. A., Trejo, C. L., Silva, J. M., Gu, S., Korkola, J., Heiser, L., Charles, R. P., Rabinovich, B. A., Hann, B., Dankort, D., Spellman, P., Phillips, W. A., Gray, J. & McMahon, M., Aug 2012, In : Cancer Discovery. 2, 8, p. 685-693 9 p.Research output: Contribution to journal › Article
ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells
Ordinario, E., Han, H. J., Furuta, S., Heiser, L., Jakkula, L. R., Rodier, F., Spellman, P., Campisi, J., Gray, J., Bissell, M. J., Kohwi, Y. & Kohwi-Shigematsu, T., Dec 10 2012, In : PLoS One. 7, 12, e51786.Research output: Contribution to journal › Article
Bayesian Inference of Signaling Network Topology in a Cancer Cell Line
Hill, S. M., Lu, Y., Molina, J., Heiser, L., Spellman, P., Speed, T. P., Gray, J., Mills, G. & Mukherjee, S., Nov 2012, In : Bioinformatics. 28, 21, p. 2804-2810 7 p.Research output: Contribution to journal › Article
Subtype and pathway specific responses to anticancer compounds in breast cancer
Heiser, L., Sadanandam, A., Kuo, W. L., Benz, S. C., Goldstein, T. C., Ng, S., Gibb, W. J., Wang, N. J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J. I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J., Durinck, S., Pepin, F., Guan, Y. & 23 others, , Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2724-2729 6 p.Research output: Contribution to journal › Article
Integrated genomic analyses of ovarian carcinoma
Bell, D., Berchuck, A., Birrer, M., Chien, J., Cramer, D. W., Dao, F., Dhir, R., Disaia, P., Gabra, H., Glenn, P., Godwin, A. K., Gross, J., Hartmann, L., Huang, M., Huntsman, D. G., Iacocca, M., Imielinski, M., Kalloger, S., Karlan, B. Y., Levine, D. A. & 277 others, , Jun 30 2011, In : Nature. 474, 7353, p. 609-615 7 p.Research output: Contribution to journal › Article
A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047
Kuo, W. L., Das, D., Ziyad, S., Bhattacharya, S., Gibb, W. J., Heiser, L., Sadanandam, A., Fontenay, G. V., Hu, Z., Wang, N. J., Bayani, N., Feiler, H., Neve, R. M., Wyrobek, A. J., Spellman, P., Marton, L. J. & Gray, J., Dec 14 2009, In : BMC Medicine. 7, 77.Research output: Contribution to journal › Article
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
Mirzoeva, O. K., Das, D., Heiser, L., Bhattacharya, S., Siwak, D., Gendelman, R., Bayani, N., Wang, N. J., Neve, R. M., Guan, Y., Hu, Z., Knight, Z., Feiler, H., Gascard, P., Parvin, B., Spellman, P., Shokat, K. M., Wyrobek, A. J., Bissell, M. J., McCormick, F. & 4 others, , Jan 15 2009, In : Cancer Research. 69, 2, p. 565-572 8 p.Research output: Contribution to journal › Article
Integrated analysis of breast cancer cell lines reveals unique signaling pathways
Heiser, L., Wang, N. J., Talcott, C. L., Laderoute, K. R., Knapp, M., Guan, Y., Hu, Z., Ziyad, S., Weber, B. L., Laquerre, S., Jackson, J. R., Wooster, R. F., Kuo, W., Gray, J. & Spellman, P., Mar 25 2009, In : Genome Biology. 10, 3, R31.Research output: Contribution to journal › Article
Analysis of molecular inversion probe performance for allele copy number determination
Wang, Y., Moorhead, M., Karlin-Neumann, G., Wang, N. J., Ireland, J., Lin, S., Chen, C., Heiser, L., Chin, K-Y., Esserman, L., Gray, J., Spellman, P. & Faham, M., Nov 20 2007, In : Genome Biology. 8, 11, R246.Research output: Contribution to journal › Article
Dynamic circuitry for updating spatial representations. III. From neurons to behavior
Berman, R. A., Heiser, L., Dunn, C. A., Saunders, R. C. & Colby, C. L., Jul 2007, In : Journal of Neurophysiology. 98, 1, p. 105-121 17 p.Research output: Contribution to journal › Article
Spatial updating in area LIP is independent of saccade direction
Heiser, L. & Colby, C. L., May 2006, In : Journal of Neurophysiology. 95, 5, p. 2751-2767 17 p.Research output: Contribution to journal › Article
Corollary discharge and spatial updating: When the brain is split, is space still unified?
Colby, C. L., Berman, R. A., Heiser, L. & Saunders, R. C., 2005, In : Progress in Brain Research. 149, p. 187-205 19 p.Research output: Contribution to journal › Article
Dynamic circuitry for updating spatial representations. I. Behavioral evidence for interhemispheric transfer in the split-brain macaque
Berman, R. A., Heiser, L., Saunders, R. C. & Colby, C. L., Nov 2005, In : Journal of Neurophysiology. 94, 5, p. 3228-3248 21 p.Research output: Contribution to journal › Article
Dynamic circuitry for updating spatial representations. II. Physiological evidence for interhemispheric transfer in area LIP of the split-brain macaque
Heiser, L., Berman, R. A., Saunders, R. C. & Colby, C. L., Nov 2005, In : Journal of Neurophysiology. 94, 5, p. 3249-3258 10 p.Research output: Contribution to journal › Article