• 5945 Citations
  • 43 h-Index
1982 …2020
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Research Output 1982 2019

  • 5945 Citations
  • 43 h-Index
  • 185 Article
  • 1 Chapter
  • 1 Conference contribution
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Article
1994
25 Citations (Scopus)

Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites

David, L., Calvin, H. I. & Fu, S. C. J., Oct 1994, In : Experimental Eye Research. 59, 4, p. 501-504 4 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Methionine Sulfoximine
Buthionine Sulfoximine
Crystallins
Inbred Strains Mice
85 Citations (Scopus)
Crystallins
Calpain
Cataract
Lenses
Proteins
1993
22 Citations (Scopus)

Role of calpain in hydrogen peroxide induced cataract

Kadoya, K., Azuma, M., David, L. & Shearer, T. T., 1993, In : Current Eye Research. 12, 4, p. 341-346 6 p.

Research output: Contribution to journalArticle

Calpain
Cataract
Hydrogen Peroxide
Lenses
Crystallins
108 Citations (Scopus)

Sequence analysis of lens β-crystallins suggests involvement of calpain in cataract formation

David, L., Shearer, T. T. & Shih, M., Jan 25 1993, In : Journal of Biological Chemistry. 268, 3, p. 1937-1940 4 p.

Research output: Contribution to journalArticle

Crystallins
Calpain
Cataract
Lenses
Sequence Analysis
89 Citations (Scopus)

α-crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract

Kelley, M., David, L., Iwasaki, N., Wright, J. & Shearer, T. T., Sep 5 1993, In : Journal of Biological Chemistry. 268, 25, p. 18844-18849 6 p.

Research output: Contribution to journalArticle

Selenious Acid
Crystallins
Calpain
Cataract
Proteolysis
51 Citations (Scopus)
Crystallins
Calpain
Cataract
Peptides
Selenious Acid
1992
5 Citations (Scopus)

Association of calpain with insoluble pellet of rat lens

Lampi, K., David, L. & Shearer, T. T., 1992, In : Experimental Eye Research. 55, 2, p. 369-375 7 p.

Research output: Contribution to journalArticle

Calpain
Lenses
Calcium
Membranes
Water
43 Citations (Scopus)

Calpain II induced insolubilization of lens β-crystallin polypeptides may induce cataract

David, L., Wright, J. W. & Shearer, T. T., Jul 7 1992, In : BBA - Molecular Basis of Disease. 1139, 3, p. 210-216 7 p.

Research output: Contribution to journalArticle

Crystallins
Calpain
Cataract
Lenses
Peptides
3 Citations (Scopus)

Calpain in rat cornea

Azuma, M., Anderson, R. S., Sameshima, S., Matsumoto, T., David, L. & Shearer, T. T., 1992, In : Investigative Ophthalmology and Visual Science. 33, 8, p. 2476-2482 7 p.

Research output: Contribution to journalArticle

Calpain
Cornea
Enzyme-Linked Immunosorbent Assay
Proteins
Egtazic Acid
21 Citations (Scopus)

Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses

Lampi, K., Kadoya, K., Azuma, M., David, L. & Shearer, T. T., 1992, In : Toxicology and Applied Pharmacology. 117, 1, p. 53-57 5 p.

Research output: Contribution to journalArticle

Cataract
Lenses
Rats
Calcium Ionophores
Permeability
15 Citations (Scopus)
Calpain
Xylose
Cataract
Proteolysis
Lenses
113 Citations (Scopus)

Review of selenite cataract

Shearer, T. T., David, L., Anderson, R. S. & Azuma, M., 1992, In : Current Eye Research. 11, 4, p. 357-369 13 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Crystallins
Lenses
Proteolysis
36 Citations (Scopus)

Superior prevention of calcium ionophore cataract by E64d

Azuma, M., David, L. & Shearer, T. T., Dec 10 1992, In : BBA - Molecular Basis of Disease. 1180, 2, p. 215-220 6 p.

Research output: Contribution to journalArticle

Calcium Ionophores
Cataract
Lenses
Calcimycin
Calpain
1991
39 Citations (Scopus)

Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64

Shearer, T. T., Azuma, M., David, L. & Murachi, T., 1991, In : Investigative Ophthalmology and Visual Science. 32, 3, p. 533-540 8 p.

Research output: Contribution to journalArticle

Cysteine Proteinase Inhibitors
Calpain
Cataract
Lenses
Proteolysis
9 Citations (Scopus)

Calpain in cultured bovine Lens epithelial cells

Lipman, R. D., Cyr, D. E., David, L. & Taylor, A., 1991, In : Current Eye Research. 10, 1, p. 11-17 7 p.

Research output: Contribution to journalArticle

Calpain
Lenses
Epithelial Cells
alpha-Crystallins
Calcium
43 Citations (Scopus)

Cysteine protease inhibitor e64 reduces the rate of formation of selenite cataract in the whole animal

Azuma, M., David, L. & Shearer, T. T., 1991, In : Current Eye Research. 10, 7, p. 657-666 10 p.

Research output: Contribution to journalArticle

Selenious Acid
Cysteine Proteinase Inhibitors
Cataract
Calpain
Lenses
1990
6 Citations (Scopus)

Calpain and calpastatin in rabbit corneal epithelium

Shearer, T. T., Azuma, M., David, L., Yamagata, Y. & Murachi, T., 1990, In : Current Eye Research. 9, 1, p. 39-44 6 p.

Research output: Contribution to journalArticle

Corneal Epithelium
Calpain
Rabbits
calpastatin
Fluorescein-5-isothiocyanate
34 Citations (Scopus)

Calpain II in two in vivo models of sugar cataract

Azuma, M., Shearer, T. T., Matsumoto, T., David, L. & Murach, T., 1990, In : Experimental Eye Research. 51, 4, p. 393-401 9 p.

Research output: Contribution to journalArticle

Calpain
Cataract
Crystallins
Lenses
Proteolysis
7 Citations (Scopus)
Vitreous Body
Crystallins
Aqueous Humor
Selenium
Cataract
1989
22 Citations (Scopus)

Age-related changes in calpain II and calpastatin in rat lens

Varnum, M. D., David, L. & Shearer, T. T., 1989, In : Experimental Eye Research. 49, 6, p. 1053-1065 13 p.

Research output: Contribution to journalArticle

Calpain
Lenses
calpastatin
Molecular Weight
Calcium
67 Citations (Scopus)

Calpain II in human lens

David, L., Varnum, M. D., Lampi, K. & Shearer, T. T., 1989, In : Investigative Ophthalmology and Visual Science. 30, 2, p. 269-275 7 p.

Research output: Contribution to journalArticle

Calpain
Lenses
Endopeptidases
Enzyme Assays
Human Activities
47 Citations (Scopus)

Role of proteolysis in lenses: A review

David, L. & Shearer, T. T., 1989, In : Lens and Eye Toxicity Research. 6, 4, p. 725-747 23 p.

Research output: Contribution to journalArticle

Lenses
Proteolysis
Peptide Hydrolases
Crystallins
Cataract
1988
18 Citations (Scopus)

Proteolytic changes in main intrinsic polypeptide (MIP26) from membranes in selenite cataract

David, L., Takemoto, L. J., Anderson, R. S. & Shearer, T. T., 1988, In : Current Eye Research. 7, 4, p. 411-417 7 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Proteolysis
Sodium Selenite
Peptides
2 Citations (Scopus)

Similar chemotactic factor for monocytes predominates in different animal models of uveitis

Rosenbaum, J. J., Seymour, B. W. P., Raymond, W., Langlois, L., Wu, M. & David, L., Jun 1988, In : Inflammation. 12, 3, p. 191-201 11 p.

Research output: Contribution to journalArticle

Chemotactic Factors
Uveitis
Monocytes
Paracentesis
Animal Models
1987
21 Citations (Scopus)

Chemotactic Activity of Lens Proteins and the Pathogenesis Of Phacolytic Glaucoma

Rosenbaum, J. J., Samples, J. R., Seymour, B., Langlois, L. & David, L., 1987, In : Archives of Ophthalmology. 105, 11, p. 1582-1584 3 p.

Research output: Contribution to journalArticle

Crystallins
Glaucoma
Lenses
Monocytes
Cataract
18 Citations (Scopus)
Selenious Acid
Crystallins
Calpain
Cataract
Proteolysis
36 Citations (Scopus)

Regional distribution of free calcium in selenite cataract: Relation to calpain II

Hightower, K. R., David, L. & Shearer, T. T., 1987, In : Investigative Ophthalmology and Visual Science. 28, 10, p. 1702-1706 5 p.

Research output: Contribution to journalArticle

Calpain
Selenious Acid
Cataract
Lenses
Calcium
12 Citations (Scopus)

Retinal pigment epithelial cells secrete substances that are chemotactic for monocytes

Rosenbaum, J. J., O'rourke, L., Davies, G., Wenger, C., David, L. & Robertson, J., 1987, In : Current Eye Research. 6, 6, p. 793-800 8 p.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Chemotactic Factors
Monocytes
Epithelial Cells
72 Citations (Scopus)

Selenite cataract: A review

Shearer, T. T., David, L. & Anderson, R. S., 1987, In : Current Eye Research. 6, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Lenses
Proteolysis
Animal Models
1986
77 Citations (Scopus)

Purification of calpain II from rat lens and determination of endogenous substrates

David, L. & Shearer, T. T., 1986, In : Experimental Eye Research. 42, 3, p. 227-238 12 p.

Research output: Contribution to journalArticle

Calpain
Lenses
Crystallins
Cataract
Proteolysis
7 Citations (Scopus)

Selenite decreases phase separation temperature in rat lens

Shearer, T. T., David, L. & Anderson, R. S., 1986, In : Experimental Eye Research. 42, 5, p. 503-506 4 p.

Research output: Contribution to journalArticle

Selenious Acid
Crystalline Lens
Selenium
Cataract
Lenses
1984
89 Citations (Scopus)
Selenious Acid
Lenses
Proteolysis
Calcium
Nuclear Proteins
51 Citations (Scopus)

State of sulfhydryl in selenite cataract

David, L. & Shearer, T. T., Jun 15 1984, In : Toxicology and Applied Pharmacology. 74, 1, p. 109-115 7 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Glutathione
Glutathione Disulfide
Buthionine Sulfoximine
1982
33 Citations (Scopus)

Role of calcium in selenium cataract

Shearer, T. T. & David, L., 1982, In : Current Eye Research. 2, 11, p. 777-784 8 p.

Research output: Contribution to journalArticle

Selenium
Cataract
Lenses
Calcium
Selenious Acid