• 6055 Citations
  • 44 h-Index
1982 …2020
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Research Output 1982 2019

  • 6055 Citations
  • 44 h-Index
  • 188 Article
  • 1 Chapter
  • 1 Conference contribution
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Article
2013
4 Citations (Scopus)

Diagnostic and therapeutic potential of tetanus toxin-derivatives in neurological diseases

Kassa, R., Monterroso, V., David, L. & Tshala-Katumbay, D., Nov 2013, In : Journal of Molecular Neuroscience. 51, 3, p. 788-791 4 p.

Research output: Contribution to journalArticle

Tetanus Toxin
Motor Neurons
Mass Spectrometry
Blood-Nerve Barrier
Fluorescence
18 Citations (Scopus)

Dissection of the human multipotent adult progenitor cell secretome by proteomic analysis

Burrows, G. G., Van't Hof, W., Newell, L., Reddy, A., Wilmarth, P., David, L., Raber, A., Bogaerts, A., Pinxteren, J., Deans, R. J. & Maziarz, R., Oct 2013, In : Stem cells translational medicine. 2, 10, p. 745-757 13 p.

Research output: Contribution to journalArticle

Proteomics
Dissection
Stem Cells
Extracellular Matrix Proteins
Intercellular Signaling Peptides and Proteins
10 Citations (Scopus)

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Tran, K. D., Rodriguez-Contreras, D., Vieira, D. P., Yates, P., David, L., Beatty, W., Elferich, J. & Landfear, S., Aug 2 2013, In : Journal of Biological Chemistry. 288, 31, p. 22721-22733 13 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Flagella
Membrane Proteins
Kinetoplastida
Parasites
21 Citations (Scopus)

Mechanisms of glucagon degradation at alkaline pH

Caputo, N., Castle, J., Bergstrom, C. P., Carroll, J. M., Bakhtiani, P. A., Jackson, M. A., Roberts, C., David, L. & Ward, W. K., 2013, In : Peptides. 45, p. 40-47 8 p.

Research output: Contribution to journalArticle

Glucagon
Degradation
Isomerization
Bioactivity
Liquid Chromatography
81 Citations (Scopus)

Molecular architecture of the chick vestibular hair bundle

Shin, J. B., Krey, J. F., Hassan, A., Metlagel, Z., Tauscher, A. N., Pagana, J. M., Sherman, N. E., Jeffery, E. D., Spinelli, K. J., Zhao, H., Wilmarth, P., Choi, D., David, L., Auer, M. & Barr-Gillespie, P., Mar 2013, In : Nature Neuroscience. 16, 3, p. 365-374 10 p.

Research output: Contribution to journalArticle

Actins
Mass Spectrometry
Proteins
Electron Microscope Tomography
Stereocilia
4 Citations (Scopus)

Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c

Nili, M., David, L., Elferich, J., Shinde, U. & Rotwein, P., May 15 2013, In : Biochemical Journal. 452, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Molecular modeling
Disulfides
Proteomics
Molecules
27 Citations (Scopus)

Proteomics and phosphoproteomics analysis of human lens fiber cell membranes

Wang, Z., Han, J., David, L. & Schey, K. L., Feb 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 1135-1143 9 p.

Research output: Contribution to journalArticle

Proteomics
Lenses
Cell Membrane
Proteome
Phosphopeptides
59 Citations (Scopus)

Role of the retinal vascular endothelial cell in ocular disease

Bharadwaj, A. S., Appukuttan, B., Wilmarth, P., Pan, Y., Stempel, A. J., Chipps, T. J., Benedetti, E. E., Zamora, D. O., Choi, D., David, L. & Smith, J. R., Jan 2013, In : Progress in Retinal and Eye Research. 32, 1, p. 102-180 79 p.

Research output: Contribution to journalArticle

Retinal Vessels
Eye Diseases
Endothelial Cells
Retina
Endothelium
9 Citations (Scopus)

Shotgun proteomic analysis of S-thiolation sites of guinea pig lens nuclear crystallins following oxidative stress in vivo

Giblin, F. J., David, L., Wilmarth, P., Leverenz, V. R. & Simpanya, M. F., Feb 3 2013, In : Molecular Vision. 19, p. 267-280 14 p.

Research output: Contribution to journalArticle

Crystallins
Firearms
Proteomics
Lenses
Guinea Pigs
25 Citations (Scopus)

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

Aslan, J., Baker, S. M., Loren, C. P., Haley, K., Itakura, A., Pang, J., Greenberg, D. L., David, L., Manser, E., Chernoff, J. & McCarty, O., Sep 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 5

Research output: Contribution to journalArticle

p21-Activated Kinases
rho GTP-Binding Proteins
Platelet Activation
Thrombin
Blood Platelets
19 Citations (Scopus)

Verification and spatial localization of aquaporin-5 in the ocular lens

Grey, A. C., Walker, K. L., Petrova, R. S., Han, J., Wilmarth, P., David, L., Donaldson, P. J. & Schey, K. L., Mar 2013, In : Experimental Eye Research. 108, p. 94-102 9 p.

Research output: Contribution to journalArticle

Aquaporin 5
Crystalline Lens
Lenses
Aquaporins
Western Blotting
2012
17 Citations (Scopus)

A systems approach implicates nuclear receptor targeting in the Atp7b -/- mouse model of Wilson's disease

Wilmarth, P., Short, K. K., Fiehn, O., Lutsenko, S., David, L. & Burkhead, J. L., 2012, In : Metallomics. 4, 7, p. 660-668 9 p.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Cytoplasmic and Nuclear Receptors
Systems Analysis
Copper
Liver
7 Citations (Scopus)
Crystallins
Deuterium
Amides
Cataract
Peptides
8 Citations (Scopus)
Insulin-Like Growth Factor Binding Protein 5
Tandem Mass Spectrometry
Disulfides
Mass spectrometry
Insulin-Like Growth Factor Binding Proteins
19 Citations (Scopus)
Energy Metabolism
Mass Spectrometry
Epithelium
Proteins
Oxidative Phosphorylation
51 Citations (Scopus)

HIF1α protein stability is increased by acetylation at lysine 709

Geng, H., Liu, Q., Xue, C., David, L., Beer, T. T., Thomas, G., Dai, M. & Qian, Z. D., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35496-35505 10 p.

Research output: Contribution to journalArticle

Acetylation
Protein Stability
Lysine
Proteins
Cells
15 Citations (Scopus)

Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?

Truscott, R. J. W., Mizdrak, J., Friedrich, M. G., Hooi, M. Y., Lyons, B., Jamie, J. F., Davies, M. J., Wilmarth, P. & David, L., Jun 2012, In : Experimental Eye Research. 99, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Crystallins
Methylation
Lenses
Proteins
20 Citations (Scopus)

Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas

Jackson, M. A., Caputo, N., Castle, J., David, L., Roberts, C. & Ward, W. K., Dec 2012, In : Current Diabetes Reports. 12, 6, p. 705-710 6 p.

Research output: Contribution to journalArticle

Glucagon
Pancreas
Glucagon Receptors
Asparagine
Cyclic AMP-Dependent Protein Kinases
2011
14 Citations (Scopus)

Calreticulin binds to gentamicin and reduces drug-induced ototoxicity

Karasawa, T., Wang, Q., David, L. & Steyger, P., Dec 2011, In : Toxicological Sciences. 124, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

Calreticulin
Gentamicins
Aminoglycosides
Pharmaceutical Preparations
Cytotoxicity
18 Citations (Scopus)

Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease

Burkhead, J. L., Ralle, M., Wilmarth, P., David, L. & Lutsenko, S., Feb 11 2011, In : Journal of Molecular Biology. 406, 1, p. 44-58 15 p.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Copper
RNA
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Liver
38 Citations (Scopus)

Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity

Yang, Y., Dai, M., Wilson, T. M., Omelchenko, I., Klimek, J. E., Wilmarth, P., David, L., Nuttall, A., Barr-Gillespie, P. & Shi, X., 2011, In : PLoS One. 6, 1, e16547.

Research output: Contribution to journalArticle

sodium-potassium-exchanging ATPase
Inner Ear
blood proteins
Adenosine Triphosphatases
Blood Proteins
5 Citations (Scopus)

Nascent proteomes of ischemic-injured and ischemic-tolerant neuronal cells

Zhou, A., Simon, R. P. & David, L., Feb 2011, In : International Journal of Computational Biology and Drug Design. 4, 1, p. 40-55 16 p.

Research output: Contribution to journalArticle

Proteome
Proteins
Brain
Computational Biology
Epigenomics
28 Citations (Scopus)

Novel biomarker candidates to predict hepatic fibrosis in hepatitis C identified by serum proteomics

Yang, L., Rudser, K. D., Higgins, L., Rosen, H. R., Zaman, A., Corless, C., David, L. & Gourley, G. R., Nov 2011, In : Digestive Diseases and Sciences. 56, 11, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

Hepatitis C
Proteomics
Fibrosis
Biomarkers
Liver
21 Citations (Scopus)

On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure

Kassa, R. M., Kasensa, N. L., Monterroso, V. H., Kayton, R. J., Klimek, J. E., David, L., Lunganza, K. R., Kayembe, K. T., Bentivoglio, M., Juliano, S. L. & Tshala-Katumbay, D., Mar 2011, In : Food and Chemical Toxicology. 49, 3, p. 571-578 8 p.

Research output: Contribution to journalArticle

Sulfur Amino Acids
Manihot
Motor Neuron Disease
sulfur amino acids
Biomarkers
16 Citations (Scopus)
Protein Databases
Proteomics
Databases
Chemical analysis
Proteins
6 Citations (Scopus)

Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes

Feng, X., Feistel, T., Buffalo, C., McCormack, A., Kruvand, E., Rodriguez-Contreras, D., Akopyants, N. S., Umasankar, P. K., David, L., Jardim, A., Beverley, S. M. & Landfear, S., Jan 2011, In : Molecular and Biochemical Parasitology. 175, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Facilitative Glucose Transport Proteins
Messenger RNA
Parasites
Genes
24 Citations (Scopus)

Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation

Matsumura, Y., David, L. & Skach, W., Aug 15 2011, In : Molecular Biology of the Cell. 22, 16, p. 2797-2809 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum-Associated Degradation
Cystic Fibrosis Transmembrane Conductance Regulator
Proteasome Endopeptidase Complex
Proteolysis
Cell-Free System
2010
21 Citations (Scopus)

CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity

Karasawa, T., Wang, Q., David, L. & Steyger, P., Nov 2010, In : Cell Death and Disease. 1, 11, e102.

Research output: Contribution to journalArticle

Gentamicins
Cytoskeleton
Carrier Proteins
Membrane Proteins
Pharmaceutical Preparations
6 Citations (Scopus)

Proteomic analysis of biopsied human colonic mucosa

Gourley, G. R., Yang, L., Higgins, L., Riviere, M. A. & David, L., Jul 2010, In : Journal of Pediatric Gastroenterology and Nutrition. 51, 1, p. 46-54 9 p.

Research output: Contribution to journalArticle

Proteomics
Mucous Membrane
Liquid Chromatography
Proteins
Electrophoresis
32 Citations (Scopus)

Role of Hsp90 in biogenesis of the β-cell ATP-sensitive potassium channel complex

Yan, F. F., Pratt, E. B., Chen, P. C., Wang, F., Skach, W., David, L. & Shyng, S-L., Jun 15 2010, In : Molecular Biology of the Cell. 21, 12, p. 1945-1954 10 p.

Research output: Contribution to journalArticle

KATP Channels
Sulfonylurea Receptors
Proteins
HSC70 Heat-Shock Proteins
Insulin
10 Citations (Scopus)

Solvent accessibility of βB2-crystallin and local structural changes due to deamidation at the dimer interface

Takata, T., Smith, J. P., Arbogast, B., David, L. & Lampi, K., Sep 2010, In : Experimental Eye Research. 91, 3, p. 336-346 11 p.

Research output: Contribution to journalArticle

Crystallins
Deuterium
Hydrogen
Lenses
Mass Spectrometry
34 Citations (Scopus)

The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa

Honda, S., Lewis, Z. A., Huarte, M., Cho, L. Y., David, L., Shi, Y. & Selker, E. U., Mar 1 2010, In : Genes and Development. 24, 5, p. 443-454 12 p.

Research output: Contribution to journalArticle

Neurospora crassa
DNA Transposable Elements
DNA Methylation
DNA
Methylation
77 Citations (Scopus)

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

Shin, J. B., Longo-Guess, C. M., Gagnon, L. H., Saylor, K. W., Dumont, R. A., Spinelli, K. J., Pagana, J. M., Wilmarth, P., David, L., Barr-Gillespie, P. & Johnson, K. R., Jul 21 2010, In : Journal of Neuroscience. 30, 29, p. 9683-9694 12 p.

Research output: Contribution to journalArticle

Stereocilia
Inbred DBA Mouse
Hearing Loss
Hair
Actins
2009
107 Citations (Scopus)

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

Rozansky, D., Cornwall, T., Subramanya, A. R., Rogers, S., Yang, Y. F., David, L., Zhu, X., Yang, C-L. & Ellison, D., Sep 1 2009, In : Journal of Clinical Investigation. 119, 9, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Aldosterone
Glucocorticoids
Phosphotransferases
Serum
8 Citations (Scopus)
Crystallins
Calcium Ionophores
Cataract
Lenses
Lysine
29 Citations (Scopus)

Methionine sulfoxide reductase A (MsrA) restores α-crystallin chaperone activity lost upon methionine oxidation

Brennan, L. A., Lee, W., Giblin, F. J., David, L. & Kantorow, M., Dec 2009, In : Biochimica et Biophysica Acta - General Subjects. 1790, 12, p. 1665-1672 8 p.

Research output: Contribution to journalArticle

Methionine Sulfoxide Reductases
Crystallins
Methionine
Oxidation
Proteins
35 Citations (Scopus)

Nucleotide oligomerization domain-2 interacts with 2′-5′-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells

Dugan, J. W., Albor, A., David, L., Fowlkes, J., Blackledge, M. T., Martin, T., Planck, S., Rosenzweig, H., Rosenbaum, J. J. & Davey, M., Dec 2009, In : Molecular Immunology. 47, 2-3, p. 560-566 7 p.

Research output: Contribution to journalArticle

Ligases
Nucleotides
Innate Immunity
RNA Virus Infections
Double-Stranded RNA
30 Citations (Scopus)

Quantification of isotopically overlapping deamidated and 18O-labeled peptides using isotopic Envelope mixture modeling

Dasari, S., Wilmarth, P., Reddy, A. P., Robertson, L. J. G., Nagalla, S. R. & David, L., Mar 6 2009, In : Journal of Proteome Research. 8, 3, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

Peptides
Lenses
Crystallins
Workflow
Water
47 Citations (Scopus)
Crystallins
Firearms
Proteomics
Protein Databases
Lenses
76 Citations (Scopus)

The membrane proteome of the mouse lens fiber cell.

Bassnett, S., Wilmarth, P. & David, L., 2009, In : Molecular Vision. 15, p. 2448-2463 16 p.

Research output: Contribution to journalArticle

Proteome
Lenses
Membranes
Cell Membrane
Membrane Proteins
2008
45 Citations (Scopus)

Accurate annotation of peptide modifications through unrestrictive database search

Tanner, S., Payne, S. H., Dasari, S., Shen, Z., Wilmarth, P., David, L., Loomis, W. F., Briggs, S. P. & Bafna, V., Jan 2008, In : Journal of Proteome Research. 7, 1, p. 170-181 12 p.

Research output: Contribution to journalArticle

Signal transduction
Post Translational Protein Processing
Polymorphism
Mass spectrometry
Databases
15 Citations (Scopus)

Expressed sequence tag analysis of guinea pig (Cavia porcellus) eye tissues for NEIBank

Simpanya, M. F., Wistow, G., Gao, J., David, L., Giblin, F. J. & Mitton, K. P., Dec 19 2008, In : Molecular Vision. 14, p. 2413-2427 15 p.

Research output: Contribution to journalArticle

Expressed Sequence Tags
Sequence Analysis
Crystallins
Guinea Pigs
Lenses
5 Citations (Scopus)

Fibrinogen Hershey IV: A novel dysfibrinogen with a γV411I mutation in the integrin αIIbβ3 binding site

Flood, V. H., Al-Mondhiry, H. A., Rein, C. M., Alexander, K. S., Lovely, R. S., Shackleton, K. M., David, L. & Farrell, D., Jun 2008, In : Thrombosis and Haemostasis. 99, 6, p. 1008-1012 5 p.

Research output: Contribution to journalArticle

Integrins
Fibrinogen
Binding Sites
Blood Platelets
Mutation
23 Citations (Scopus)

Susceptibility of ovine lens crystallins to proteolytic cleavage during formation of hereditary cataract

Robertson, L. J. G., David, L., Riviere Phillip, M. A., Wilmarth, A., Muir, M. S. & Morton, J. D., Mar 2008, In : Investigative Ophthalmology and Visual Science. 49, 3, p. 1016-1022 7 p.

Research output: Contribution to journalArticle

Crystallins
Cataract
Lenses
Sheep
Proteolysis
2007
22 Citations (Scopus)

Biophysical Properties of γC-Crystallin in Human and Mouse Eye Lens: The Role of Molecular Dipoles

Purkiss, A. G., Bateman, O. A., Wyatt, K., Wilmarth, P., David, L., Wistow, G. J. & Slingsby, C., Sep 7 2007, In : Journal of Molecular Biology. 372, 1, p. 205-222 18 p.

Research output: Contribution to journalArticle

Crystalline Lens
Crystallins
Solubility
Lenses
Cysteine
40 Citations (Scopus)

Proteomic profiling of human retinal and choroidal endothelial cells reveals molecular heterogeneity related to tissue of origin

Zamora, D. O., Riviere, M., Choi, D., Pan, Y., Planck, S., Rosenbaum, J. J., David, L. & Smith, J. R., Oct 30 2007, In : Molecular Vision. 13, p. 2058-2065 8 p.

Research output: Contribution to journalArticle

Proteomics
Endothelial Cells
Proteins
Two-Dimensional Difference Gel Electrophoresis
Ubiquitin Thiolesterase
27 Citations (Scopus)

Reliable detection of deamidated peptides from lens crystallin proteins using changes in reversed-phase elution times and parent ion masses

Dasari, S., Wilmarth, P., Rustvold, D. L., Riviere, M. A., Nagalla, S. R. & David, L., Sep 2007, In : Journal of Proteome Research. 6, 9, p. 3819-3826 8 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Ions
Peptides
Proteins
2006
180 Citations (Scopus)

Age-related changes in human crystalline determined from comparative analysis of post-translational modifications in young and aged lens: Does deamidation contribute to crystallin insolubility?

Wilmarth, P., Tanner, S., Dasari, S., Nagalla, S. R., Riviere, M. A., Bafha, V., Pevzner, P. A. & David, L., Oct 2006, In : Journal of Proteome Research. 5, 10, p. 2554-2566 13 p.

Research output: Contribution to journalArticle

Crystallins
Post Translational Protein Processing
Lenses
Solubility
Crystalline materials
23 Citations (Scopus)

Biochemical properties of lens-specific calpain Lp85

Shih, M., Ma, H., Nakajima, E., David, L., Azuma, M. & Shearer, T. T., Jan 2006, In : Experimental Eye Research. 82, 1, p. 146-152 7 p.

Research output: Contribution to journalArticle

Lenses
Crystallins
Calpain
Calcium
Hydrolysis
40 Citations (Scopus)

Calpain-specific proteolysis in primate retina: Contribution of calpains in cell death

Nakajima, E., David, L., Bystrom, C., Shearer, T. T. & Azuma, M., Dec 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5469-5475 7 p.

Research output: Contribution to journalArticle

Calpain
Primates
Proteolysis
Retina
Cell Death