Kristine Wiren

Professor Emeritus

  • 1878 Citations
  • 25 h-Index
1986 …2020
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Research Output 1986 2018

  • 1878 Citations
  • 25 h-Index
  • 60 Article
  • 4 Chapter
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Article
2018
2 Citations (Scopus)

Binge ethanol drinking produces sexually divergent and distinct changes in nucleus accumbens signaling cascades and pathways in adult C57BL/6J mice

Finn, D. D., Hashimoto, J. G., Cozzoli, D. K., Helms, M. L., Nipper, M. A., Kaufman, M. N., Wiren, K. & Guizzetti, M., Sep 10 2018, In : Frontiers in Genetics. 9, SEP, 325.

Research output: Contribution to journalArticle

Binge Drinking
Nucleus Accumbens
Inbred C57BL Mouse
Ethanol
Genes

The androgen receptor in bone marrow progenitor cells negatively regulates fat mass

Russell, P. K., Mangiafico, S., Fam, B. C., Clarke, M. V., Marin, E. S., Andrikopoulos, S., Wiren, K., Zajac, J. D. & Davey, R. A., Apr 1 2018, In : Journal of Endocrinology. 237, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Androgen Receptors
Bone Marrow Cells
Intra-Abdominal Fat
Stem Cells
Fats
2017
5 Citations (Scopus)

Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence

Hashimoto, J. G., Gavin, D. P., Wiren, K., Crabbe, J. J. & Guizzetti, M., May 1 2017, In : Alcohol. 60, p. 83-94 12 p.

Research output: Contribution to journalArticle

Modifier Genes
seizure
Prefrontal Cortex
withdrawal
Chromatin
2016
3 Citations (Scopus)

A neurotoxic alcohol exposure paradigm does not induce hepatic encephalopathy

Hashimoto, J. G., Wiren, K. & Wilhelm, C., Jul 1 2016, In : Neurotoxicology and Teratology. 56, p. 35-40 6 p.

Research output: Contribution to journalArticle

Hepatic Encephalopathy
Alcohols
Frontal Lobe
Brain
Glutathione
16 Citations (Scopus)

Astrocyte Dysfunction Induced by Alcohol in Females but Not Males

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Andrew, M. R. & Wiren, K., Jul 1 2016, In : Brain Pathology. 26, 4, p. 433-451 19 p.

Research output: Contribution to journalArticle

Astrocytes
Alcohols
Ethanol
Cytokines
Excitatory Amino Acids
13 Citations (Scopus)

Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice

Cozzoli, D. K., Kaufman, M. N., Nipper, M. A., Hashimoto, J. G., Wiren, K. & Finn, D. D., Jun 1 2016, In : Neuropharmacology. 105, p. 164-174 11 p.

Research output: Contribution to journalArticle

Binge Drinking
1-Phosphatidylinositol 4-Kinase
Alcohol Drinking
Nucleus Accumbens
Sirolimus
2015
8 Citations (Scopus)

Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation

Russell, P. K., Clarke, M. V., Cheong, K., Anderson, P. H., Morris, H. A., Wiren, K., Zajac, J. D. & Davey, R. A., May 1 2015, In : Journal of Bone and Mineral Research. 30, 5, p. 809-823 15 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteoblasts
Androgens
Puberty
Growth
10 Citations (Scopus)

Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Beard, D. K. & Wiren, K., Mar 19 2015, In : Brain Research. 1601, p. 102-116 15 p., 44024.

Research output: Contribution to journalArticle

Glucocorticoids
Alcohols
Corticosterone
Prefrontal Cortex
Cell Death
2014
9 Citations (Scopus)

The effect of mGluR5 antagonism during binge drinking on subsequent ethanol intake in C57BL/6J mice: Sex- and age-induced differences

Cozzoli, D. K., Strong-Kaufman, M. N., Tanchuck, M. A., Hashimoto, J. G., Wiren, K. & Finn, D. D., 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 730-738 9 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
Binge Drinking
Inbred C57BL Mouse
Ethanol
Animals
16 Citations (Scopus)

Understanding the addiction cycle: A complex biology with distinct contributions of genotype vs. sex at each stage

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Sonmez, M. K. & Wiren, K., Sep 4 2014, In : Neuroscience. 279, p. 168-186 19 p.

Research output: Contribution to journalArticle

Genotype
Alcoholism
Phenotype
Seizures
Ethanol
2013
8 Citations (Scopus)
Sex Characteristics
Hippocampus
Ethanol
Neurons
2012
19 Citations (Scopus)

Androgen prevents hypogonadal bone loss via inhibition of resorption mediated by mature osteoblasts/osteocytes

Wiren, K., Zhang, X. W., Olson, D. A., Turner, R. T. & Iwaniec, U. T., Nov 2012, In : Bone. 51, 5, p. 835-846 12 p.

Research output: Contribution to journalArticle

Osteocytes
Osteoblasts
Androgen Receptors
Androgens
Genotype
2011
3 Citations (Scopus)

Androgen Receptor Overexpression Is Neuroprotective in Experimental Stroke

Ayala, P., Uchida, M., Akiyoshi, K., Cheng, J., Hashimoto, J., Jia, T., Ronnekleiv, O., Murphy, S. J., Wiren, K. & Hurn, P. D., Sep 2011, In : Translational Stroke Research. 2, 3, p. 346-357 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Stroke
Dihydrotestosterone
Middle Cerebral Artery Infarction
PC12 Cells
25 Citations (Scopus)

Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

Semirale, A. A., Zhang, X. W. & Wiren, K., Jul 2011, In : Journal of Cellular Biochemistry. 112, 7, p. 1773-1786 14 p.

Research output: Contribution to journalArticle

Cell Lineage
Body Composition
Stem cells
Androgens
Stem Cells
12 Citations (Scopus)

Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

Wiren, K., Hashimoto, J. G., Semirale, A. A. & Zhang, X. W., Oct 2011, In : Bone. 49, 4, p. 662-672 11 p.

Research output: Contribution to journalArticle

Neural Crest
Frontal Bone
Osteoblasts
Adipocytes
Androgens
11 Citations (Scopus)

Elevated testosterone in females reveals a robust sex difference in altered androgen levels during chronic alcohol withdrawal

Forquer, M. R., Hashimoto, J. G., Roberts, M. L. & Wiren, K., Mar 2011, In : Alcohol. 45, 2, p. 161-171 11 p.

Research output: Contribution to journalArticle

Sex Characteristics
withdrawal
Androgens
Testosterone
Seizures
19 Citations (Scopus)

Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication

Hashimoto, J. G., Forquer, M. R., Tanchuck, M. A., Finn, D. D. & Wiren, K., Jan 26 2011, In : Neuroscience. 173, p. 57-75 19 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Prefrontal Cortex
Seizures
Gene Expression
Recurrence
8 Citations (Scopus)

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

Lebold, K. M., Grant, K. K., Freeman, W. M., Wiren, K., Miller, G. W., Kiley, C., Leonard, S. W. & Traber, M. G., Mar 2011, In : Alcoholism: Clinical and Experimental Research. 35, 3, p. 474-483 10 p.

Research output: Contribution to journalArticle

Self Administration
Macaca fascicularis
Hyperlipidemias
Vitamin E
Individuality
3 Citations (Scopus)

Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes

Wiren, K., Hashimoto, J. G. & Zhang, X. W., Dec 2011, In : Journal of Cellular Biochemistry. 112, 12, p. 3638-3647 10 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Body Composition
Stem cells
Stem Cells
Chemical activation
2010
14 Citations (Scopus)

Signaling pathways implicated in androgen regulation of endocortical bone

Wiren, K., Semirale, A. A., Hashimoto, J. G. & Zhang, X. W., Mar 2010, In : Bone. 46, 3, p. 710-723 14 p.

Research output: Contribution to journalArticle

Androgens
Bone and Bones
Androgen Receptors
Osteoblasts
Bone Morphogenetic Proteins
2009
48 Citations (Scopus)

Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C., Janowsky, A., Franken, F. H., Wiren, K., Hashimoto, J. G., Scibelli, A. C. & Phillips, T., Nov 2009, In : Genes, Brain and Behavior. 8, 8, p. 758-771 14 p.

Research output: Contribution to journalArticle

Methamphetamine
Self Administration
Pharmaceutical Preparations
Genes
Gene Expression
14 Citations (Scopus)
Pregnanolone
Enzyme activity
Oxidoreductases
Ethanol
Seizures
2008
47 Citations (Scopus)

Neurotoxic consequences of chronic alcohol withdrawal: Expression profiling reveals importance of gender over withdrawal severity

Hashimoto, J. G. & Wiren, K., Apr 2008, In : Neuropsychopharmacology. 33, 5, p. 1084-1096 13 p.

Research output: Contribution to journalArticle

Ethanol
Alcohols
Alcoholism
Brain
Cell Death
45 Citations (Scopus)

Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis. A model for compartment-specific androgen action in the skeleton

Wiren, K., Semirale, A. A., Zhang, X. W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B. & Jepsen, K. J., Sep 2008, In : Bone. 43, 3, p. 440-451 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteogenesis
Skeleton
Androgens
Bone and Bones
2007
28 Citations (Scopus)

Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice

Gorin-Meyer, R. E., Wiren, K., Tanchuck, M. A., Long, S. L., Yoneyama, N. & Finn, D. D., May 25 2007, In : Neuroscience. 146, 3, p. 1302-1315 14 p.

Research output: Contribution to journalArticle

Finasteride
Inbred DBA Mouse
Sex Characteristics
Ethanol
Pregnanolone
2006
108 Citations (Scopus)

A new look at the 5α-reductase inhibitor finasteride

Finn, D. D., Beadles-Bohling, A. S., Beckley, E. H., Ford, M., Gililland, K. R., Gorin-Meyer, R. E. & Wiren, K., Mar 2006, In : CNS Drug Reviews. 12, 1, p. 53-76 24 p.

Research output: Contribution to journalArticle

Finasteride
Oxidoreductases
Steroids
20-alpha-Dihydroprogesterone
Protein Isoforms
20 Citations (Scopus)

Anticonvulsive effects of κ-Opioid receptor modulation in an animal model of ethanol withdrawal

Beadles-Bohling, A. S. & Wiren, K., Aug 2006, In : Genes, Brain and Behavior. 5, 6, p. 483-496 14 p.

Research output: Contribution to journalArticle

Opioid Receptors
Seizures
Ethanol
Animal Models
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
28 Citations (Scopus)

Impact of sex: Determination of alcohol neuroadaptation and reinforcement

Wiren, K., Hashimoto, J. G., Alele, P. E., Devaud, L. L., Price, K. L., Middaugh, L. D., Grant, K. K. & Finn, D. D., Feb 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

Reinforcement
Ethanol
Alcohols
Sex Characteristics
Self Administration
59 Citations (Scopus)

Osteoblast and osteocyte apoptosis associated with androgen action in bone: Requirement of increased Bax/Bcl-2 ratio

Wiren, K., Toombs, A. R., Semirale, A. A. & Zhang, X., May 2006, In : Bone. 38, 5, p. 637-651 15 p.

Research output: Contribution to journalArticle

Osteocytes
Osteoblasts
Androgens
Apoptosis
Dihydrotestosterone
87 Citations (Scopus)

Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Bliziotes, M., Eshleman, A., Burt-Pichat, B., Zhang, X. W., Hashimoto, J., Wiren, K. & Chenu, C., Dec 2006, In : Bone. 39, 6, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Serotonin Receptors
Serotonin
Receptor, Serotonin, 5-HT2A
Osteocytes
2005
15 Citations (Scopus)

Alcohol effects on central nervous system gene expression in genetic animal models

McBride, W. J., Kerns, R. T., Rodd, Z. A., Strother, W. N., Edenberg, H. J., Hashimoto, J. G., Wiren, K. & Miles, M. F., Feb 2005, In : Alcoholism: Clinical and Experimental Research. 29, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Genetic Models
Neurology
Gene expression
Animals
Ethanol
19 Citations (Scopus)

Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity

Beadles-Bohling, A. S. & Wiren, K., Jun 7 2005, In : Brain Research. 1046, 1-2, p. 77-89 13 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Genetic Models
Seizures
Ethanol
Brain
33 Citations (Scopus)

Androgens and bone growth: It's location, location, location

Wiren, K., Dec 2005, In : Current Opinion in Pharmacology. 5, 6 SPEC. ISS., p. 626-632 7 p.

Research output: Contribution to journalArticle

Bone Development
Androgens
Bone and Bones
Androgen Receptors
Osteoclasts
60 Citations (Scopus)

Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine)

Warden, S. J., Bliziotes, M. M., Wiren, K., Eshleman, A. J. & Turner, C. H., Oct 20 2005, In : Molecular and Cellular Endocrinology. 242, 1-2, p. 1-9 9 p.

Research output: Contribution to journalArticle

Serotonin
Bone
Bone and Bones
Metabolism
Skeleton
2004
26 Citations (Scopus)

Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts

Wiren, K., Toombs, A. R. & Zhang, X. W., Feb 2004, In : Journal of Molecular Endocrinology. 32, 1, p. 209-226 18 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Osteoblasts
Androgens
Phosphotransferases
Androgen Receptor Antagonists
90 Citations (Scopus)

Comparison of RiboGreen® and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis

Hashimoto, J. G., Beadles-Bohling, A. S. & Wiren, K., Jan 2004, In : BioTechniques. 36, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

18S Ribosomal RNA
Online Systems
Online systems
Fluorescence Spectrometry
Gene Expression Profiling
59 Citations (Scopus)

Targeted overexpression of androgen receptor in osteoblasts: Unexpected complex bone phenotype in growing animals

Wiren, K., Zhang, X. W., Toombs, A. R., Kasparcova, V., Gentile, M. A., Harada, S. I. & Jepsen, K. J., Jul 2004, In : Endocrinology. 145, 7, p. 3507-3522 16 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteoblasts
Phenotype
Bone and Bones
Transgenic Mice
75 Citations (Scopus)
Pregnanolone
Behavioral Genetics
Pregnanes
Neurotransmitter Agents
Ethanol
2002
61 Citations (Scopus)

Osteoblast differentiation influences androgen and estrogen receptor-α and -β expression

Wiren, K., Evans, A. C. & Zhang, X. W., Dec 1 2002, In : Journal of Endocrinology. 175, 3, p. 683-694 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteoblasts
Estrogen Receptors
Estrogens
Androgens
49 Citations (Scopus)

The role of dopamine and serotonin in regulating bone mass and strength: Studies on dopamine and serotonin transporter null mice

Bliziotes, M., Gunness, M., Eshleman, A. & Wiren, K., 2002, In : Journal of Musculoskeletal Neuronal Interactions. 2, 3, p. 291-295 5 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Dopamine
Serotonin
Bone and Bones
2001
21 Citations (Scopus)

Ethanol-regulated gene expression of neuroendocrine specific protein in mice: Brain region and genotype specificity

Schafer, G. L., Crabbe, J. J. & Wiren, K., Apr 6 2001, In : Brain Research. 897, 1-2, p. 139-149 11 p.

Research output: Contribution to journalArticle

Ethanol
Genotype
Gene Expression
Brain
Seizures
169 Citations (Scopus)

Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake

Bliziotes, M. M., Eshleman, A. J., Zhang, X. W. & Wiren, K., 2001, In : Bone. 29, 5, p. 477-486 10 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Osteoblasts
Neurotransmitter Agents
Serotonin
Receptor, Serotonin, 5-HT2B
28 Citations (Scopus)

Regulated Nuclear-Cytoplasmic Localization of CCAAT/Enhancer-binding Protein δ in Osteoblasts

Billiard, J., Umayahara, Y., Wiren, K., Centrella, M., McCarthy, T. L. & Rotwein, P., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 15354-15361 8 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Osteoblasts
Protein Kinases
Insulin-Like Growth Factor I
Dinoprostone
2000
17 Citations (Scopus)

Elevated prodynorphin expression associated with ethanol withdrawal convulsions

Beadles-Bohling, A. S., Crabbe, J. J. & Wiren, K., Nov 1 2000, In : Neurochemistry International. 37, 5-6, p. 463-472 10 p.

Research output: Contribution to journalArticle

Seizures
Ethanol
Glyceraldehyde-3-Phosphate Dehydrogenases
Messenger RNA
preproenkephalin
13 Citations (Scopus)

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function

Bliziotes, M., Gunness, M., Zhang, X. W., Nissenson, R. & Wiren, K., Sep 2000, In : Bone. 27, 3, p. 367-373 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Mitogen-Activated Protein Kinases
Osteoblasts
G-Protein-Coupled Receptor Kinases
Intercellular Signaling Peptides and Proteins
1999
28 Citations (Scopus)

Homologous androgen receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness

Wiren, K., Keenan, E., Zhang, X., Ramsey, B. & Orwoll, E., 1999, In : Endocrinology. 140, 7, p. 3114-3124 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Up-Regulation
Dihydrotestosterone
Cell Line
1998
17 Citations (Scopus)

Identification of neuroendocrine-specific protein as an ethanol- regulated gene with mRNA differential display

Schafer, G. L., Crabbe, J. J. & Wiren, K., 1998, In : Mammalian Genome. 9, 12, p. 979-982 4 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Ethanol
Genes
Proteins
Seizures
1997
81 Citations (Scopus)

Transcriptional up-regulation of the human androgen receptor by androgen in bone cells

Wiren, K., Zhang, X., Chang, C., Keenan, E. & Orwoll, E., 1997, In : Endocrinology. 138, 6, p. 2291-2300 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Up-Regulation
Bone and Bones
Osteoblasts
1996
21 Citations (Scopus)

β-Adrenergic receptor kinase-like activity and β-arrestin are expressed in osteoblastic cells

Bliziotes, M., Murtagh, J. & Wiren, K., Jun 1996, In : Journal of Bone and Mineral Research. 11, 6, p. 820-826 7 p.

Research output: Contribution to journalArticle

Arrestin
Adrenergic Receptors
Phosphotransferases
Rhodopsin
Phosphorylation
1995
51 Citations (Scopus)

Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts

Birnbaum, R. S., Bowsher, R. R. & Wiren, K., 1995, In : Journal of Endocrinology. 144, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Osteoblasts
Insulin-Like Growth Factor I
Mitogens
Extracellular Matrix