Kristine Wiren &ndash; Publications

2018

Binge ethanol drinking produces sexually divergent and distinct changes in nucleus accumbens signaling cascades and pathways in adult C57BL/6J mice

Finn, D. D., Hashimoto, J. G., Cozzoli, D. K., Helms, M. L., Nipper, M. A., Kaufman, M. N., Wiren, K. & Guizzetti, M., Sep 10 2018, In : Frontiers in Genetics. 9, SEP, 325.

Research output: Contribution to journal › Article

Binge Drinking

Nucleus Accumbens

Inbred C57BL Mouse

Ethanol

Genes

The androgen receptor in bone marrow progenitor cells negatively regulates fat mass

Russell, P. K., Mangiafico, S., Fam, B. C., Clarke, M. V., Marin, E. S., Andrikopoulos, S., Wiren, K., Zajac, J. D. & Davey, R. A., Apr 1 2018, In : Journal of Endocrinology. 237, 1, p. 15-27 13 p.

Research output: Contribution to journal › Article

Androgen Receptors

Bone Marrow Cells

Intra-Abdominal Fat

Stem Cells

Fats

2017

5 Citations (Scopus)

Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence

Hashimoto, J. G., Gavin, D. P., Wiren, K., Crabbe, J. J. & Guizzetti, M., May 1 2017, In : Alcohol. 60, p. 83-94 12 p.

Research output: Contribution to journal › Article

Modifier Genes

seizure

Prefrontal Cortex

withdrawal

Chromatin

2016

3 Citations (Scopus)

A neurotoxic alcohol exposure paradigm does not induce hepatic encephalopathy

Hashimoto, J. G., Wiren, K. & Wilhelm, C., Jul 1 2016, In : Neurotoxicology and Teratology. 56, p. 35-40 6 p.

Research output: Contribution to journal › Article

Hepatic Encephalopathy

Alcohols

Frontal Lobe

Brain

Glutathione

16 Citations (Scopus)

Astrocyte Dysfunction Induced by Alcohol in Females but Not Males

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Andrew, M. R. & Wiren, K., Jul 1 2016, In : Brain Pathology. 26, 4, p. 433-451 19 p.

Research output: Contribution to journal › Article

Astrocytes

Alcohols

Ethanol

Cytokines

Excitatory Amino Acids

13 Citations (Scopus)

Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice

Cozzoli, D. K., Kaufman, M. N., Nipper, M. A., Hashimoto, J. G., Wiren, K. & Finn, D. D., Jun 1 2016, In : Neuropharmacology. 105, p. 164-174 11 p.

Research output: Contribution to journal › Article

Binge Drinking

1-Phosphatidylinositol 4-Kinase

Alcohol Drinking

Nucleus Accumbens

Sirolimus

2015

8 Citations (Scopus)

Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation

Russell, P. K., Clarke, M. V., Cheong, K., Anderson, P. H., Morris, H. A., Wiren, K., Zajac, J. D. & Davey, R. A., May 1 2015, In : Journal of Bone and Mineral Research. 30, 5, p. 809-823 15 p.

Research output: Contribution to journal › Article

Androgen Receptors

Osteoblasts

Androgens

Puberty

Growth

10 Citations (Scopus)

Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Beard, D. K. & Wiren, K., Mar 19 2015, In : Brain Research. 1601, p. 102-116 15 p., 44024.

Research output: Contribution to journal › Article

Glucocorticoids

Alcohols

Corticosterone

Prefrontal Cortex

Cell Death

2014

9 Citations (Scopus)

The effect of mGluR5 antagonism during binge drinking on subsequent ethanol intake in C57BL/6J mice: Sex- and age-induced differences

Cozzoli, D. K., Strong-Kaufman, M. N., Tanchuck, M. A., Hashimoto, J. G., Wiren, K. & Finn, D. D., 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 730-738 9 p.

Research output: Contribution to journal › Article

Metabotropic Glutamate 5 Receptor

Binge Drinking

Inbred C57BL Mouse

Ethanol

Animals

16 Citations (Scopus)

Understanding the addiction cycle: A complex biology with distinct contributions of genotype vs. sex at each stage

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Sonmez, M. K. & Wiren, K., Sep 4 2014, In : Neuroscience. 279, p. 168-186 19 p.

Research output: Contribution to journal › Article

Genotype

Alcoholism

Phenotype

Seizures

Ethanol

2013

8 Citations (Scopus)

Males and females are just different: Sexually dimorphic responses to chronic ethanol exposure in hippocampal slice cultures

Wiren, K., Aug 29 2013, In : Neuroscience Letters. 550, p. 1-5 5 p.

Research output: Contribution to journal › Article

Sex Characteristics

Hippocampus

Ethanol

Neurons

2012

19 Citations (Scopus)

Androgen prevents hypogonadal bone loss via inhibition of resorption mediated by mature osteoblasts/osteocytes

Wiren, K., Zhang, X. W., Olson, D. A., Turner, R. T. & Iwaniec, U. T., Nov 2012, In : Bone. 51, 5, p. 835-846 12 p.

Research output: Contribution to journal › Article

Osteocytes

Osteoblasts

Androgen Receptors

Androgens

Genotype

2011

3 Citations (Scopus)

Androgen Receptor Overexpression Is Neuroprotective in Experimental Stroke

Ayala, P., Uchida, M., Akiyoshi, K., Cheng, J., Hashimoto, J., Jia, T., Ronnekleiv, O., Murphy, S. J., Wiren, K. & Hurn, P. D., Sep 2011, In : Translational Stroke Research. 2, 3, p. 346-357 12 p.

Research output: Contribution to journal › Article

Androgen Receptors

Stroke

Dihydrotestosterone

Middle Cerebral Artery Infarction

PC12 Cells

25 Citations (Scopus)

Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

Semirale, A. A., Zhang, X. W. & Wiren, K., Jul 2011, In : Journal of Cellular Biochemistry. 112, 7, p. 1773-1786 14 p.

Research output: Contribution to journal › Article

Cell Lineage

Body Composition

Stem cells

Androgens

Stem Cells

12 Citations (Scopus)

Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

Wiren, K., Hashimoto, J. G., Semirale, A. A. & Zhang, X. W., Oct 2011, In : Bone. 49, 4, p. 662-672 11 p.

Research output: Contribution to journal › Article

Neural Crest

Frontal Bone

Osteoblasts

Adipocytes

Androgens

11 Citations (Scopus)

Elevated testosterone in females reveals a robust sex difference in altered androgen levels during chronic alcohol withdrawal

Forquer, M. R., Hashimoto, J. G., Roberts, M. L. & Wiren, K., Mar 2011, In : Alcohol. 45, 2, p. 161-171 11 p.

Research output: Contribution to journal › Article

Sex Characteristics

withdrawal

Androgens

Testosterone

Seizures

19 Citations (Scopus)

Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication

Hashimoto, J. G., Forquer, M. R., Tanchuck, M. A., Finn, D. D. & Wiren, K., Jan 26 2011, In : Neuroscience. 173, p. 57-75 19 p.

Research output: Contribution to journal › Article

Alcoholic Intoxication

Prefrontal Cortex

Seizures

Gene Expression

Recurrence

8 Citations (Scopus)

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

Lebold, K. M., Grant, K. K., Freeman, W. M., Wiren, K., Miller, G. W., Kiley, C., Leonard, S. W. & Traber, M. G., Mar 2011, In : Alcoholism: Clinical and Experimental Research. 35, 3, p. 474-483 10 p.

Research output: Contribution to journal › Article

Self Administration

Macaca fascicularis

Hyperlipidemias

Vitamin E

Individuality

3 Citations (Scopus)

Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes

Wiren, K., Hashimoto, J. G. & Zhang, X. W., Dec 2011, In : Journal of Cellular Biochemistry. 112, 12, p. 3638-3647 10 p.

Research output: Contribution to journal › Article

Dihydrotestosterone

Body Composition

Stem cells

Stem Cells

Chemical activation

2010

14 Citations (Scopus)

Signaling pathways implicated in androgen regulation of endocortical bone

Wiren, K., Semirale, A. A., Hashimoto, J. G. & Zhang, X. W., Mar 2010, In : Bone. 46, 3, p. 710-723 14 p.

Research output: Contribution to journal › Article

Androgens

Bone and Bones

Androgen Receptors

Osteoblasts

Bone Morphogenetic Proteins

2009

48 Citations (Scopus)

Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C., Janowsky, A., Franken, F. H., Wiren, K., Hashimoto, J. G., Scibelli, A. C. & Phillips, T., Nov 2009, In : Genes, Brain and Behavior. 8, 8, p. 758-771 14 p.

Research output: Contribution to journal › Article

Methamphetamine

Self Administration

Pharmaceutical Preparations

Genes

Gene Expression

14 Citations (Scopus)

Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5α-Reductase Enzyme Activity and Expression

Tanchuck, M. A., Long, S. L., Ford, M., Hashimoto, J., Crabbe, J. J., Roselli, C., Wiren, K. & Finn, D. D., Dec 2009, In : Alcoholism: Clinical and Experimental Research. 33, 12, p. 2077-2087 11 p.

Research output: Contribution to journal › Article

Pregnanolone

Enzyme activity

Oxidoreductases

Ethanol

Seizures

2008

47 Citations (Scopus)

Neurotoxic consequences of chronic alcohol withdrawal: Expression profiling reveals importance of gender over withdrawal severity

Hashimoto, J. G. & Wiren, K., Apr 2008, In : Neuropsychopharmacology. 33, 5, p. 1084-1096 13 p.

Research output: Contribution to journal › Article

Ethanol

Alcohols

Alcoholism

Brain

Cell Death

45 Citations (Scopus)

Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis. A model for compartment-specific androgen action in the skeleton

Wiren, K., Semirale, A. A., Zhang, X. W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B. & Jepsen, K. J., Sep 2008, In : Bone. 43, 3, p. 440-451 12 p.

Research output: Contribution to journal › Article

Androgen Receptors

Osteogenesis

Skeleton

Androgens

Bone and Bones

2007

28 Citations (Scopus)

Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice

Gorin-Meyer, R. E., Wiren, K., Tanchuck, M. A., Long, S. L., Yoneyama, N. & Finn, D. D., May 25 2007, In : Neuroscience. 146, 3, p. 1302-1315 14 p.

Research output: Contribution to journal › Article

Finasteride

Inbred DBA Mouse

Sex Characteristics

Ethanol

Pregnanolone

2006

108 Citations (Scopus)

A new look at the 5α-reductase inhibitor finasteride

Finn, D. D., Beadles-Bohling, A. S., Beckley, E. H., Ford, M., Gililland, K. R., Gorin-Meyer, R. E. & Wiren, K., Mar 2006, In : CNS Drug Reviews. 12, 1, p. 53-76 24 p.

Research output: Contribution to journal › Article

Finasteride

Oxidoreductases

Steroids

20-alpha-Dihydroprogesterone

Protein Isoforms

20 Citations (Scopus)

Anticonvulsive effects of κ-Opioid receptor modulation in an animal model of ethanol withdrawal

Beadles-Bohling, A. S. & Wiren, K., Aug 2006, In : Genes, Brain and Behavior. 5, 6, p. 483-496 14 p.

Research output: Contribution to journal › Article

Opioid Receptors

Seizures

Ethanol

Animal Models

(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide

28 Citations (Scopus)

Impact of sex: Determination of alcohol neuroadaptation and reinforcement

Wiren, K., Hashimoto, J. G., Alele, P. E., Devaud, L. L., Price, K. L., Middaugh, L. D., Grant, K. K. & Finn, D. D., Feb 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 233-242 10 p.

Research output: Contribution to journal › Article

Reinforcement

Ethanol

Alcohols

Sex Characteristics

Self Administration

59 Citations (Scopus)

Osteoblast and osteocyte apoptosis associated with androgen action in bone: Requirement of increased Bax/Bcl-2 ratio

Wiren, K., Toombs, A. R., Semirale, A. A. & Zhang, X., May 2006, In : Bone. 38, 5, p. 637-651 15 p.

Research output: Contribution to journal › Article

Osteocytes

Osteoblasts

Androgens

Apoptosis

Dihydrotestosterone

87 Citations (Scopus)

Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Bliziotes, M., Eshleman, A., Burt-Pichat, B., Zhang, X. W., Hashimoto, J., Wiren, K. & Chenu, C., Dec 2006, In : Bone. 39, 6, p. 1313-1321 9 p.

Research output: Contribution to journal › Article

Serotonin Plasma Membrane Transport Proteins

Serotonin Receptors

Serotonin

Receptor, Serotonin, 5-HT2A

Osteocytes

2005

15 Citations (Scopus)

Alcohol effects on central nervous system gene expression in genetic animal models

McBride, W. J., Kerns, R. T., Rodd, Z. A., Strother, W. N., Edenberg, H. J., Hashimoto, J. G., Wiren, K. & Miles, M. F., Feb 2005, In : Alcoholism: Clinical and Experimental Research. 29, 2, p. 167-175 9 p.

Research output: Contribution to journal › Article

Genetic Models

Neurology

Gene expression

Animals

Ethanol

19 Citations (Scopus)

Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity

Beadles-Bohling, A. S. & Wiren, K., Jun 7 2005, In : Brain Research. 1046, 1-2, p. 77-89 13 p.

Research output: Contribution to journal › Article

kappa Opioid Receptor

Genetic Models

Seizures

Ethanol

Brain

33 Citations (Scopus)

Androgens and bone growth: It's location, location, location

Wiren, K., Dec 2005, In : Current Opinion in Pharmacology. 5, 6 SPEC. ISS., p. 626-632 7 p.

Research output: Contribution to journal › Article

Bone Development

Androgens

Bone and Bones

Androgen Receptors

Osteoclasts

60 Citations (Scopus)

Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine)

Warden, S. J., Bliziotes, M. M., Wiren, K., Eshleman, A. J. & Turner, C. H., Oct 20 2005, In : Molecular and Cellular Endocrinology. 242, 1-2, p. 1-9 9 p.

Research output: Contribution to journal › Article

Serotonin

Bone

Bone and Bones

Metabolism

Skeleton

2004

26 Citations (Scopus)

Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts

Wiren, K., Toombs, A. R. & Zhang, X. W., Feb 2004, In : Journal of Molecular Endocrinology. 32, 1, p. 209-226 18 p.

Research output: Contribution to journal › Article

Dihydrotestosterone

Osteoblasts

Androgens

Phosphotransferases

Androgen Receptor Antagonists

90 Citations (Scopus)

Comparison of RiboGreen® and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis

Hashimoto, J. G., Beadles-Bohling, A. S. & Wiren, K., Jan 2004, In : BioTechniques. 36, 1, p. 54-60 7 p.

Research output: Contribution to journal › Article

18S Ribosomal RNA

Online Systems

Online systems

Fluorescence Spectrometry

Gene Expression Profiling

59 Citations (Scopus)

Targeted overexpression of androgen receptor in osteoblasts: Unexpected complex bone phenotype in growing animals

Wiren, K., Zhang, X. W., Toombs, A. R., Kasparcova, V., Gentile, M. A., Harada, S. I. & Jepsen, K. J., Jul 2004, In : Endocrinology. 145, 7, p. 3507-3522 16 p.

Research output: Contribution to journal › Article

Androgen Receptors

Osteoblasts

Phenotype

Bone and Bones

Transgenic Mice

75 Citations (Scopus)

The role of pregnane neurosteroids in ethanol withdrawal: Behavioral genetic approaches

Finn, D. D., Ford, M., Wiren, K., Roselli, C. & Crabbe, J. J., Feb 2004, In : Pharmacology and Therapeutics. 101, 2, p. 91-112 22 p.

Research output: Contribution to journal › Article

Pregnanolone

Behavioral Genetics

Pregnanes

Neurotransmitter Agents

Ethanol

2002

61 Citations (Scopus)

Osteoblast differentiation influences androgen and estrogen receptor-α and -β expression

Wiren, K., Evans, A. C. & Zhang, X. W., Dec 1 2002, In : Journal of Endocrinology. 175, 3, p. 683-694 12 p.

Research output: Contribution to journal › Article

Androgen Receptors

Osteoblasts

Estrogen Receptors

Estrogens

Androgens

49 Citations (Scopus)

The role of dopamine and serotonin in regulating bone mass and strength: Studies on dopamine and serotonin transporter null mice

Bliziotes, M., Gunness, M., Eshleman, A. & Wiren, K., 2002, In : Journal of Musculoskeletal Neuronal Interactions. 2, 3, p. 291-295 5 p.

Research output: Contribution to journal › Article

Serotonin Plasma Membrane Transport Proteins

Dopamine Plasma Membrane Transport Proteins

Dopamine

Serotonin

Bone and Bones

2001

21 Citations (Scopus)

Ethanol-regulated gene expression of neuroendocrine specific protein in mice: Brain region and genotype specificity

Schafer, G. L., Crabbe, J. J. & Wiren, K., Apr 6 2001, In : Brain Research. 897, 1-2, p. 139-149 11 p.

Research output: Contribution to journal › Article

Ethanol

Genotype

Gene Expression

Brain

Seizures

169 Citations (Scopus)

Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake

Bliziotes, M. M., Eshleman, A. J., Zhang, X. W. & Wiren, K., 2001, In : Bone. 29, 5, p. 477-486 10 p.

Research output: Contribution to journal › Article

Serotonin Receptors

Osteoblasts

Neurotransmitter Agents

Serotonin

Receptor, Serotonin, 5-HT2B

28 Citations (Scopus)

Regulated Nuclear-Cytoplasmic Localization of CCAAT/Enhancer-binding Protein δ in Osteoblasts

Billiard, J., Umayahara, Y., Wiren, K., Centrella, M., McCarthy, T. L. & Rotwein, P., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 15354-15361 8 p.

Research output: Contribution to journal › Article

CCAAT-Enhancer-Binding Proteins

Osteoblasts

Protein Kinases

Insulin-Like Growth Factor I

Dinoprostone

2000

17 Citations (Scopus)

Elevated prodynorphin expression associated with ethanol withdrawal convulsions

Beadles-Bohling, A. S., Crabbe, J. J. & Wiren, K., Nov 1 2000, In : Neurochemistry International. 37, 5-6, p. 463-472 10 p.

Research output: Contribution to journal › Article

Seizures

Ethanol

Glyceraldehyde-3-Phosphate Dehydrogenases

Messenger RNA

preproenkephalin

13 Citations (Scopus)

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function

Bliziotes, M., Gunness, M., Zhang, X. W., Nissenson, R. & Wiren, K., Sep 2000, In : Bone. 27, 3, p. 367-373 7 p.

Research output: Contribution to journal › Article

G-Protein-Coupled Receptor Kinase 2

Mitogen-Activated Protein Kinases

Osteoblasts

G-Protein-Coupled Receptor Kinases

Intercellular Signaling Peptides and Proteins

1999

28 Citations (Scopus)

Homologous androgen receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness

Wiren, K., Keenan, E., Zhang, X., Ramsey, B. & Orwoll, E., 1999, In : Endocrinology. 140, 7, p. 3114-3124 11 p.

Research output: Contribution to journal › Article

Androgen Receptors

Androgens

Up-Regulation

Dihydrotestosterone

Cell Line

1998

17 Citations (Scopus)

Identification of neuroendocrine-specific protein as an ethanol- regulated gene with mRNA differential display

Schafer, G. L., Crabbe, J. J. & Wiren, K., 1998, In : Mammalian Genome. 9, 12, p. 979-982 4 p.

Research output: Contribution to journal › Article

Gene Expression Profiling

Ethanol

Genes

Proteins

Seizures

1997

81 Citations (Scopus)

Transcriptional up-regulation of the human androgen receptor by androgen in bone cells

Wiren, K., Zhang, X., Chang, C., Keenan, E. & Orwoll, E., 1997, In : Endocrinology. 138, 6, p. 2291-2300 10 p.

Research output: Contribution to journal › Article

Androgen Receptors

Androgens

Up-Regulation

Bone and Bones

Osteoblasts

1996

21 Citations (Scopus)

β-Adrenergic receptor kinase-like activity and β-arrestin are expressed in osteoblastic cells

Bliziotes, M., Murtagh, J. & Wiren, K., Jun 1996, In : Journal of Bone and Mineral Research. 11, 6, p. 820-826 7 p.

Research output: Contribution to journal › Article

Arrestin

Adrenergic Receptors

Phosphotransferases

Rhodopsin

Phosphorylation

1995

51 Citations (Scopus)

Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts

Birnbaum, R. S., Bowsher, R. R. & Wiren, K., 1995, In : Journal of Endocrinology. 144, 2, p. 251-259 9 p.

Research output: Contribution to journal › Article

Insulin-Like Growth Factor II

Osteoblasts

Insulin-Like Growth Factor I

Mitogens

Extracellular Matrix