Kristine Wiren

Professor Emeritus

  • 1892 Citations
  • 25 h-Index
1986 …2020
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Research Output 1986 2018

  • 1892 Citations
  • 25 h-Index
  • 60 Article
  • 4 Chapter
Article
15 Citations (Scopus)

Alcohol effects on central nervous system gene expression in genetic animal models

McBride, W. J., Kerns, R. T., Rodd, Z. A., Strother, W. N., Edenberg, H. J., Hashimoto, J. G., Wiren, K. & Miles, M. F., Feb 2005, In : Alcoholism: Clinical and Experimental Research. 29, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Genetic Models
Neurology
Gene expression
Animals
Ethanol
19 Citations (Scopus)

Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity

Beadles-Bohling, A. S. & Wiren, K., Jun 7 2005, In : Brain Research. 1046, 1-2, p. 77-89 13 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Genetic Models
Seizures
Ethanol
Brain
27 Citations (Scopus)

Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts

Wiren, K., Toombs, A. R. & Zhang, X. W., Feb 2004, In : Journal of Molecular Endocrinology. 32, 1, p. 209-226 18 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Osteoblasts
Androgens
Phosphotransferases
Androgen Receptor Antagonists
20 Citations (Scopus)

Androgen prevents hypogonadal bone loss via inhibition of resorption mediated by mature osteoblasts/osteocytes

Wiren, K., Zhang, X. W., Olson, D. A., Turner, R. T. & Iwaniec, U. T., Nov 2012, In : Bone. 51, 5, p. 835-846 12 p.

Research output: Contribution to journalArticle

Osteocytes
Osteoblasts
Androgen Receptors
Androgens
Genotype
8 Citations (Scopus)

Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation

Russell, P. K., Clarke, M. V., Cheong, K., Anderson, P. H., Morris, H. A., Wiren, K., Zajac, J. D. & Davey, R. A., May 1 2015, In : Journal of Bone and Mineral Research. 30, 5, p. 809-823 15 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteoblasts
Androgens
Puberty
Growth
3 Citations (Scopus)

Androgen Receptor Overexpression Is Neuroprotective in Experimental Stroke

Ayala, P., Uchida, M., Akiyoshi, K., Cheng, J., Hashimoto, J., Jia, T., Ronnekleiv, O., Murphy, S. J., Wiren, K. & Hurn, P. D., Sep 2011, In : Translational Stroke Research. 2, 3, p. 346-357 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Stroke
Dihydrotestosterone
Middle Cerebral Artery Infarction
PC12 Cells
33 Citations (Scopus)

Androgens and bone growth: It's location, location, location

Wiren, K., Dec 2005, In : Current Opinion in Pharmacology. 5, 6 SPEC. ISS., p. 626-632 7 p.

Research output: Contribution to journalArticle

Bone Development
Androgens
Bone and Bones
Androgen Receptors
Osteoclasts
3 Citations (Scopus)

A neurotoxic alcohol exposure paradigm does not induce hepatic encephalopathy

Hashimoto, J. G., Wiren, K. & Wilhelm, C., Jul 1 2016, In : Neurotoxicology and Teratology. 56, p. 35-40 6 p.

Research output: Contribution to journalArticle

Hepatic Encephalopathy
Alcohols
Frontal Lobe
Brain
Glutathione
109 Citations (Scopus)

A new look at the 5α-reductase inhibitor finasteride

Finn, D. D., Beadles-Bohling, A. S., Beckley, E. H., Ford, M., Gililland, K. R., Gorin-Meyer, R. E. & Wiren, K., Mar 2006, In : CNS Drug Reviews. 12, 1, p. 53-76 24 p.

Research output: Contribution to journalArticle

Finasteride
Oxidoreductases
Steroids
20-alpha-Dihydroprogesterone
Protein Isoforms
20 Citations (Scopus)

Anticonvulsive effects of κ-Opioid receptor modulation in an animal model of ethanol withdrawal

Beadles-Bohling, A. S. & Wiren, K., Aug 2006, In : Genes, Brain and Behavior. 5, 6, p. 483-496 14 p.

Research output: Contribution to journalArticle

Opioid Receptors
Seizures
Ethanol
Animal Models
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
17 Citations (Scopus)

Astrocyte Dysfunction Induced by Alcohol in Females but Not Males

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Andrew, M. R. & Wiren, K., Jul 1 2016, In : Brain Pathology. 26, 4, p. 433-451 19 p.

Research output: Contribution to journalArticle

Astrocytes
Alcohols
Ethanol
Cytokines
Excitatory Amino Acids
2 Citations (Scopus)

Binge ethanol drinking produces sexually divergent and distinct changes in nucleus accumbens signaling cascades and pathways in adult C57BL/6J mice

Finn, D. D., Hashimoto, J. G., Cozzoli, D. K., Helms, M. L., Nipper, M. A., Kaufman, M. N., Wiren, K. & Guizzetti, M., Sep 10 2018, In : Frontiers in Genetics. 9, SEP, 325.

Research output: Contribution to journalArticle

Binge Drinking
Nucleus Accumbens
Inbred C57BL Mouse
Ethanol
Genes
25 Citations (Scopus)

Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

Semirale, A. A., Zhang, X. W. & Wiren, K., Jul 2011, In : Journal of Cellular Biochemistry. 112, 7, p. 1773-1786 14 p.

Research output: Contribution to journalArticle

Cell Lineage
Body Composition
Stem cells
Androgens
Stem Cells
12 Citations (Scopus)

Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

Wiren, K., Hashimoto, J. G., Semirale, A. A. & Zhang, X. W., Oct 2011, In : Bone. 49, 4, p. 662-672 11 p.

Research output: Contribution to journalArticle

Neural Crest
Frontal Bone
Osteoblasts
Adipocytes
Androgens
51 Citations (Scopus)

Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts

Birnbaum, R. S., Bowsher, R. R. & Wiren, K., 1995, In : Journal of Endocrinology. 144, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Osteoblasts
Insulin-Like Growth Factor I
Mitogens
Extracellular Matrix
78 Citations (Scopus)
Insulin-Like Growth Factor Binding Proteins
Osteoblasts
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 3
Messenger RNA
90 Citations (Scopus)

Comparison of RiboGreen® and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis

Hashimoto, J. G., Beadles-Bohling, A. S. & Wiren, K., Jan 2004, In : BioTechniques. 36, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

18S Ribosomal RNA
Online Systems
Online systems
Fluorescence Spectrometry
Gene Expression Profiling
13 Citations (Scopus)

Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence.

Freeman, M. W., Wiren, K., Rapoport, A., Lazar, M., Potts, J. T. & Kronenberg, H. M., Sep 1987, In : Molecular endocrinology (Baltimore, Md.). 1, 9, p. 628-638 11 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Cell-Free System
Amino Acid Sequence
Microsomes
Proteins
42 Citations (Scopus)

Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma

Plymate, S. R., Loop, S. M., Hoop, R. C., Wiren, K., Ostenson, R., Hryb, D. J. & Rosner, W., 1991, In : Journal of Steroid Biochemistry and Molecular Biology. 40, 4-6, p. 833-839 7 p.

Research output: Contribution to journalArticle

Sex Hormone-Binding Globulin
Carcinoma
Dihydrotestosterone
Albumins
Cells
17 Citations (Scopus)

Elevated prodynorphin expression associated with ethanol withdrawal convulsions

Beadles-Bohling, A. S., Crabbe, J. J. & Wiren, K., Nov 1 2000, In : Neurochemistry International. 37, 5-6, p. 463-472 10 p.

Research output: Contribution to journalArticle

Seizures
Ethanol
Glyceraldehyde-3-Phosphate Dehydrogenases
Messenger RNA
preproenkephalin
11 Citations (Scopus)

Elevated testosterone in females reveals a robust sex difference in altered androgen levels during chronic alcohol withdrawal

Forquer, M. R., Hashimoto, J. G., Roberts, M. L. & Wiren, K., Mar 2011, In : Alcohol. 45, 2, p. 161-171 11 p.

Research output: Contribution to journalArticle

Sex Characteristics
withdrawal
Androgens
Testosterone
Seizures
21 Citations (Scopus)

Ethanol-regulated gene expression of neuroendocrine specific protein in mice: Brain region and genotype specificity

Schafer, G. L., Crabbe, J. J. & Wiren, K., Apr 6 2001, In : Brain Research. 897, 1-2, p. 139-149 11 p.

Research output: Contribution to journalArticle

Ethanol
Genotype
Gene Expression
Brain
Seizures
10 Citations (Scopus)

Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Beard, D. K. & Wiren, K., Mar 19 2015, In : Brain Research. 1601, p. 102-116 15 p., 44024.

Research output: Contribution to journalArticle

Glucocorticoids
Alcohols
Corticosterone
Prefrontal Cortex
Cell Death
9 Citations (Scopus)

Functional cloning vectors for use in directional cDNA cloning using cohesive ends produced with T4 DNA polymerase

Kuijper, J. L., Wiren, K., Mathies, L. D., Gray, C. L. & Hagen, F. S., Mar 15 1992, In : Gene. 112, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

Genetic Vectors
DNA-Directed DNA Polymerase
Organism Cloning
Complementary DNA
DNA
13 Citations (Scopus)

Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice

Cozzoli, D. K., Kaufman, M. N., Nipper, M. A., Hashimoto, J. G., Wiren, K. & Finn, D. D., Jun 1 2016, In : Neuropharmacology. 105, p. 164-174 11 p.

Research output: Contribution to journalArticle

Binge Drinking
1-Phosphatidylinositol 4-Kinase
Alcohol Drinking
Nucleus Accumbens
Sirolimus
49 Citations (Scopus)

Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C., Janowsky, A., Franken, F. H., Wiren, K., Hashimoto, J. G., Scibelli, A. C. & Phillips, T., Nov 2009, In : Genes, Brain and Behavior. 8, 8, p. 758-771 14 p.

Research output: Contribution to journalArticle

Methamphetamine
Self Administration
Pharmaceutical Preparations
Genes
Gene Expression
28 Citations (Scopus)

Homologous androgen receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness

Wiren, K., Keenan, E., Zhang, X., Ramsey, B. & Orwoll, E., 1999, In : Endocrinology. 140, 7, p. 3114-3124 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Up-Regulation
Dihydrotestosterone
Cell Line
17 Citations (Scopus)

Identification of neuroendocrine-specific protein as an ethanol- regulated gene with mRNA differential display

Schafer, G. L., Crabbe, J. J. & Wiren, K., 1998, In : Mammalian Genome. 9, 12, p. 979-982 4 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Ethanol
Genes
Proteins
Seizures
28 Citations (Scopus)

Impact of sex: Determination of alcohol neuroadaptation and reinforcement

Wiren, K., Hashimoto, J. G., Alele, P. E., Devaud, L. L., Price, K. L., Middaugh, L. D., Grant, K. K. & Finn, D. D., Feb 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

Reinforcement
Ethanol
Alcohols
Sex Characteristics
Self Administration
19 Citations (Scopus)

Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication

Hashimoto, J. G., Forquer, M. R., Tanchuck, M. A., Finn, D. D. & Wiren, K., Jan 26 2011, In : Neuroscience. 173, p. 57-75 19 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Prefrontal Cortex
Seizures
Gene Expression
Recurrence
33 Citations (Scopus)

Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function

Wiren, K., Potts, J. T. & Kronenberg, H. M., 1988, In : Journal of Biological Chemistry. 263, 36, p. 19771-19777 7 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Peptides
Protein Precursors
Amino Acids
Complementary DNA
8 Citations (Scopus)

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

Lebold, K. M., Grant, K. K., Freeman, W. M., Wiren, K., Miller, G. W., Kiley, C., Leonard, S. W. & Traber, M. G., Mar 2011, In : Alcoholism: Clinical and Experimental Research. 35, 3, p. 474-483 10 p.

Research output: Contribution to journalArticle

Self Administration
Macaca fascicularis
Hyperlipidemias
Vitamin E
Individuality
4 Citations (Scopus)

Interaction of nascent preproparathyroid hormone molecules with microsomal membranes

Baba, H., Karaplis, A. C., Wiren, K., Keutmann, H. T. & Kronenberg, H. M., Feb 1992, In : Journal of Bone and Mineral Research. 7, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

Membranes
Ribosomes
Puromycin
Peptides
Protein Sorting Signals
8 Citations (Scopus)
Sex Characteristics
Hippocampus
Ethanol
Neurons
12 Citations (Scopus)

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties

Wiren, K., Ivashkiv, L., Ma, P., Freeman, M. W., Potts, J. T. & Kronenberg, H. M., 1989, In : Molecular Endocrinology. 3, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

Protein Transport
Protein Sorting Signals
Mutation
Membranes
Membrane Proteins
60 Citations (Scopus)

Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine)

Warden, S. J., Bliziotes, M. M., Wiren, K., Eshleman, A. J. & Turner, C. H., Oct 20 2005, In : Molecular and Cellular Endocrinology. 242, 1-2, p. 1-9 9 p.

Research output: Contribution to journalArticle

Serotonin
Bone
Bone and Bones
Metabolism
Skeleton
49 Citations (Scopus)

Neurotoxic consequences of chronic alcohol withdrawal: Expression profiling reveals importance of gender over withdrawal severity

Hashimoto, J. G. & Wiren, K., Apr 2008, In : Neuropsychopharmacology. 33, 5, p. 1084-1096 13 p.

Research output: Contribution to journalArticle

Ethanol
Alcohols
Alcoholism
Brain
Cell Death
171 Citations (Scopus)

Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake

Bliziotes, M. M., Eshleman, A. J., Zhang, X. W. & Wiren, K., 2001, In : Bone. 29, 5, p. 477-486 10 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Osteoblasts
Neurotransmitter Agents
Serotonin
Receptor, Serotonin, 5-HT2B
59 Citations (Scopus)

Osteoblast and osteocyte apoptosis associated with androgen action in bone: Requirement of increased Bax/Bcl-2 ratio

Wiren, K., Toombs, A. R., Semirale, A. A. & Zhang, X., May 2006, In : Bone. 38, 5, p. 637-651 15 p.

Research output: Contribution to journalArticle

Osteocytes
Osteoblasts
Androgens
Apoptosis
Dihydrotestosterone
63 Citations (Scopus)

Osteoblast differentiation influences androgen and estrogen receptor-α and -β expression

Wiren, K., Evans, A. C. & Zhang, X. W., Dec 1 2002, In : Journal of Endocrinology. 175, 3, p. 683-694 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteoblasts
Estrogen Receptors
Estrogens
Androgens
5 Citations (Scopus)

Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence

Hashimoto, J. G., Gavin, D. P., Wiren, K., Crabbe, J. J. & Guizzetti, M., May 1 2017, In : Alcohol. 60, p. 83-94 12 p.

Research output: Contribution to journalArticle

Modifier Genes
seizure
Prefrontal Cortex
withdrawal
Chromatin

Preproparathyroid hormone. A model for analyzing the secretory pathway.

Wiren, K., Freeman, M. W., Potts, J. T. & Kronenberg, H. M., 1987, In : Annals of the New York Academy of Sciences. 493, p. 43-49 7 p.

Research output: Contribution to journalArticle

Protein Precursors
Secretory Pathway
Protein Sorting Signals
Parathyroid Hormone
Animals
13 Citations (Scopus)

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function

Bliziotes, M., Gunness, M., Zhang, X. W., Nissenson, R. & Wiren, K., Sep 2000, In : Bone. 27, 3, p. 367-373 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Mitogen-Activated Protein Kinases
Osteoblasts
G-Protein-Coupled Receptor Kinases
Intercellular Signaling Peptides and Proteins
28 Citations (Scopus)

Regulated Nuclear-Cytoplasmic Localization of CCAAT/Enhancer-binding Protein δ in Osteoblasts

Billiard, J., Umayahara, Y., Wiren, K., Centrella, M., McCarthy, T. L. & Rotwein, P., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 15354-15361 8 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Osteoblasts
Protein Kinases
Insulin-Like Growth Factor I
Dinoprostone
38 Citations (Scopus)

Regulation of osteoblastic gene expression by lead

Klein, R. & Wiren, K., Jun 1993, In : Endocrinology. 132, 6, p. 2531-2537 7 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Osteoblasts
Messenger RNA
Alkaline Phosphatase
Lead
14 Citations (Scopus)
Pregnanolone
Enzyme activity
Oxidoreductases
Ethanol
Seizures
87 Citations (Scopus)

Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Bliziotes, M., Eshleman, A., Burt-Pichat, B., Zhang, X. W., Hashimoto, J., Wiren, K. & Chenu, C., Dec 2006, In : Bone. 39, 6, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Serotonin Receptors
Serotonin
Receptor, Serotonin, 5-HT2A
Osteocytes
28 Citations (Scopus)

Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice

Gorin-Meyer, R. E., Wiren, K., Tanchuck, M. A., Long, S. L., Yoneyama, N. & Finn, D. D., May 25 2007, In : Neuroscience. 146, 3, p. 1302-1315 14 p.

Research output: Contribution to journalArticle

Finasteride
Inbred DBA Mouse
Sex Characteristics
Ethanol
Pregnanolone
14 Citations (Scopus)

Signaling pathways implicated in androgen regulation of endocortical bone

Wiren, K., Semirale, A. A., Hashimoto, J. G. & Zhang, X. W., Mar 2010, In : Bone. 46, 3, p. 710-723 14 p.

Research output: Contribution to journalArticle

Androgens
Bone and Bones
Androgen Receptors
Osteoblasts
Bone Morphogenetic Proteins
3 Citations (Scopus)

Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes

Wiren, K., Hashimoto, J. G. & Zhang, X. W., Dec 2011, In : Journal of Cellular Biochemistry. 112, 12, p. 3638-3647 10 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Body Composition
Stem cells
Stem Cells
Chemical activation