Kristine Wiren

Professor Emeritus

  • 1936 Citations
  • 25 h-Index
1986 …2020

Research output per year

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Research Output

  • 1936 Citations
  • 25 h-Index
  • 52 Article
  • 7 Review article
  • 4 Chapter
  • 1 Comment/debate
Article

Alcohol effects on central nervous system gene expression in genetic animal models

McBride, W. J., Kerns, R. T., Rodd, Z. A., Strother, W. N., Edenberg, H. J., Hashimoto, J. G., Wiren, K. M. & Miles, M. F., Feb 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity

Beadles-Bohling, A. S. & Wiren, K. M., Jun 7 2005, In : Brain research. 1046, 1-2, p. 77-89 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts

Wiren, K. M., Toombs, A. R. & Zhang, X. W., Feb 1 2004, In : Journal of molecular endocrinology. 32, 1, p. 209-226 18 p.

Research output: Contribution to journalArticle

27 Scopus citations

Androgen prevents hypogonadal bone loss via inhibition of resorption mediated by mature osteoblasts/osteocytes

Wiren, K. M., Zhang, X. W., Olson, D. A., Turner, R. T. & Iwaniec, U. T., Nov 1 2012, In : Bone. 51, 5, p. 835-846 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation

Russell, P. K., Clarke, M. V., Cheong, K., Anderson, P. H., Morris, H. A., Wiren, K. M., Zajac, J. D. & Davey, R. A., May 1 2015, In : Journal of Bone and Mineral Research. 30, 5, p. 809-823 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

A neurotoxic alcohol exposure paradigm does not induce hepatic encephalopathy

Hashimoto, J. G., Wiren, K. & Wilhelm, C., Jul 1 2016, In : Neurotoxicology and Teratology. 56, p. 35-40 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Anticonvulsive effects of κ-Opioid receptor modulation in an animal model of ethanol withdrawal

Beadles-Bohling, A. S. & Wiren, K. M., Aug 1 2006, In : Genes, Brain and Behavior. 5, 6, p. 483-496 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Astrocyte Dysfunction Induced by Alcohol in Females but Not Males

Wilhelm, C., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Andrew, M. R. & Wiren, K., Jul 1 2016, In : Brain Pathology. 26, 4, p. 433-451 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Binge ethanol drinking produces sexually divergent and distinct changes in nucleus accumbens signaling cascades and pathways in adult C57BL/6J mice

Finn, D. D., Hashimoto, J. G., Cozzoli, D. K., Helms, M. L., Nipper, M. A., Kaufman, M. N., Wiren, K. & Guizzetti, M., Sep 10 2018, In : Frontiers in Genetics. 9, SEP, 325.

Research output: Contribution to journalArticle

7 Scopus citations

Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

Semirale, A. A., Zhang, X. W. & Wiren, K. M., Jul 1 2011, In : Journal of cellular biochemistry. 112, 7, p. 1773-1786 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

Wiren, K. M., Hashimoto, J. G., Semirale, A. A. & Zhang, X. W., Oct 1 2011, In : Bone. 49, 4, p. 662-672 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts

Birnbaum, R. S., Bowsher, R. R. & Wiren, K. M., Jan 1 1995, In : Journal of Endocrinology. 144, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
78 Scopus citations

Comparison of RiboGreen® and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis

Hashimoto, J. G., Beadles-Bohling, A. S. & Wiren, K. M., Jan 1 2004, In : BioTechniques. 36, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence

Freeman, M. W., Wiren, K. M., Rapoport, A., Lazar, M., Potts, J. T. & Kronenberg, H. M., Sep 1987, In : Molecular Endocrinology. 1, 9, p. 628-638 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma

Plymate, S. R., Loop, S. M., Hoop, R. C., Wiren, K. M., Ostenson, R., Hryb, D. J. & Rosner, W., 1991, In : Journal of Steroid Biochemistry and Molecular Biology. 40, 4-6, p. 833-839 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Elevated prodynorphin expression associated with ethanol withdrawal convulsions

Beadles-Bohling, A. S., Crabbe, J. C. & Wiren, K. M., Nov 1 2000, In : Neurochemistry International. 37, 5-6, p. 463-472 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Elevated testosterone in females reveals a robust sex difference in altered androgen levels during chronic alcohol withdrawal

Forquer, M. R., Hashimoto, J. G., Roberts, M. L. & Wiren, K. M., Mar 1 2011, In : Alcohol. 45, 2, p. 161-171 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ethanol-regulated gene expression of neuroendocrine specific protein in mice: Brain region and genotype specificity

Schafer, G. L., Crabbe, J. C. & Wiren, K. M., Apr 6 2001, In : Brain research. 897, 1-2, p. 139-149 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling

Wilhelm, C. J., Hashimoto, J. G., Roberts, M. L., Bloom, S. H., Beard, D. K. & Wiren, K. M., Mar 19 2015, In : Brain research. 1601, p. 102-116 15 p., 44024.

Research output: Contribution to journalArticle

10 Scopus citations

Functional cloning vectors for use in directional cDNA cloning using cohesive ends produced with T4 DNA polymerase

Kuijper, J. L., Wiren, K. M., Mathies, L. D., Gray, C. L. & Hagen, F. S., Mar 15 1992, In : Gene. 112, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice

Cozzoli, D. K., Kaufman, M. N., Nipper, M. A., Hashimoto, J. G., Wiren, K. & Finn, D. D., Jun 1 2016, In : Neuropharmacology. 105, p. 164-174 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C. L., Janowsky, A., Franken, F. H., Wiren, K. M., Hashimoto, J. G., Scibelli, A. C. & Phillips, T. J., Nov 1 2009, In : Genes, Brain and Behavior. 8, 8, p. 758-771 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Homologous androgen receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness

Wiren, K., Keenan, E., Zhang, X., Ramsey, B. & Orwoll, E., Jan 1 1999, In : Endocrinology. 140, 7, p. 3114-3124 11 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Identification of neuroendocrine-specific protein as an ethanol- regulated gene with mRNA differential display

Schafer, G. L., Crabbe, J. C. & Wiren, K. M., Dec 1 1998, In : Mammalian Genome. 9, 12, p. 979-982 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Impact of sex: Determination of alcohol neuroadaptation and reinforcement

Wiren, K. M., Hashimoto, J. G., Alele, P. E., Devaud, L. L., Price, K. L., Middaugh, L. D., Grant, K. A. & Finn, D. A., Feb 1 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication

Hashimoto, J. G., Forquer, M. R., Tanchuck, M. A., Finn, D. A. & Wiren, K. M., Jan 26 2011, In : Neuroscience. 173, p. 57-75 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function

Wiren, K. M., Potts, J. T. & Kronenberg, H. M., Dec 1 1988, In : Journal of Biological Chemistry. 263, 36, p. 19771-19777 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

Lebold, K. M., Grant, K. A., Freeman, W. M., Wiren, K. M., Miller, G. W., Kiley, C., Leonard, S. W. & Traber, M. G., Mar 1 2011, In : Alcoholism: Clinical and Experimental Research. 35, 3, p. 474-483 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Interaction of nascent preproparathyroid hormone molecules with microsomal membranes

Baba, H., Karaplis, A. C., Wiren, K. M., Keutmann, H. T. & Kronenberg, H. M., Feb 1992, In : Journal of Bone and Mineral Research. 7, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane binding properties

Wiren, K. M., Ivashkiv, L., Ma, P., Freeman, M. W., Potts, J. T. & Kronenberg, H. M., Feb 1989, In : Molecular Endocrinology. 3, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Neurotoxic consequences of chronic alcohol withdrawal: Expression profiling reveals importance of gender over withdrawal severity

Hashimoto, J. G. & Wiren, K. M., Apr 1 2008, In : Neuropsychopharmacology. 33, 5, p. 1084-1096 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake

Bliziotes, M. M., Eshleman, A. J., Zhang, X. W. & Wiren, K. M., Nov 13 2001, In : Bone. 29, 5, p. 477-486 10 p.

Research output: Contribution to journalArticle

176 Scopus citations

Osteoblast and osteocyte apoptosis associated with androgen action in bone: Requirement of increased Bax/Bcl-2 ratio

Wiren, K. M., Toombs, A. R., Semirale, A. A. & Zhang, X., May 1 2006, In : Bone. 38, 5, p. 637-651 15 p.

Research output: Contribution to journalArticle

60 Scopus citations

Osteoblast differentiation influences androgen and estrogen receptor-α and -β expression

Wiren, K. M., Evans, A. C. & Zhang, X. W., Dec 1 2002, In : Journal of Endocrinology. 175, 3, p. 683-694 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence

Hashimoto, J. G., Gavin, D. P., Wiren, K. M., Crabbe, J. C. & Guizzetti, M., May 1 2017, In : Alcohol. 60, p. 83-94 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Preproparathyroid Hormone: A Model for Analyzing the Secretory Pathway

WIREN, KRISTINE. M., FREEMAN, MASON. W., POTTS, JOHN. T. & KRONENBERG, HENRY. M., Apr 1987, In : Annals of the New York Academy of Sciences. 493, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function

Bliziotes, M., Gunness, M., Zhang, X. W., Nissenson, R. & Wiren, K., Sep 1 2000, In : Bone. 27, 3, p. 367-373 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulated Nuclear-Cytoplasmic Localization of CCAAT/Enhancer-binding Protein δ in Osteoblasts

Billiard, J., Umayahara, Y., Wiren, K., Centrella, M., McCarthy, T. L. & Rotwein, P., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 15354-15361 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Regulation of osteoblastic gene expression by lead

Klein, R. F. & Wiren, K. M., Jun 1993, In : Endocrinology. 132, 6, p. 2531-2537 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
14 Scopus citations

Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Bliziotes, M., Eshleman, A., Burt-Pichat, B., Zhang, X. W., Hashimoto, J., Wiren, K. & Chenu, C., Dec 1 2006, In : Bone. 39, 6, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice

Gorin-Meyer, R. E., Wiren, K. M., Tanchuck, M. A., Long, S. L., Yoneyama, N. & Finn, D. A., May 25 2007, In : Neuroscience. 146, 3, p. 1302-1315 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Signaling pathways implicated in androgen regulation of endocortical bone

Wiren, K. M., Semirale, A. A., Hashimoto, J. G. & Zhang, X. W., Mar 1 2010, In : Bone. 46, 3, p. 710-723 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes

Wiren, K. M., Hashimoto, J. G. & Zhang, X. W., Dec 1 2011, In : Journal of cellular biochemistry. 112, 12, p. 3638-3647 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeted overexpression of androgen receptor in osteoblasts: Unexpected complex bone phenotype in growing animals

Wiren, K. M., Zhang, X. W., Toombs, A. R., Kasparcova, V., Gentile, M. A., Harada, S. I. & Jepsen, K. J., Jul 1 2004, In : Endocrinology. 145, 7, p. 3507-3522 16 p.

Research output: Contribution to journalArticle

59 Scopus citations

Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis. A model for compartment-specific androgen action in the skeleton

Wiren, K. M., Semirale, A. A., Zhang, X. W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B. & Jepsen, K. J., Sep 1 2008, In : Bone. 43, 3, p. 440-451 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

The androgen receptor in bone marrow progenitor cells negatively regulates fat mass

Russell, P. K., Mangiafico, S., Fam, B. C., Clarke, M. V., Marin, E. S., Andrikopoulos, S., Wiren, K., Zajac, J. D. & Davey, R. A., Apr 1 2018, In : Journal of Endocrinology. 237, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

The effect of mGluR5 antagonism during binge drinking on subsequent ethanol intake in C57BL/6J mice: Sex- and age-induced differences

Cozzoli, D. K., Strong-Kaufman, M. N., Tanchuck, M. A., Hashimoto, J. G., Wiren, K. M. & Finn, D. A., Mar 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 730-738 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Transcriptional up-regulation of the human androgen receptor by androgen in bone cells

Wiren, K. M., Zhang, X., Chang, C., Keenan, E. & Orwoll, E. S., Jan 1 1997, In : Endocrinology. 138, 6, p. 2291-2300 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations