Kristine Wiren

Professor Emeritus

  • 1936 Citations
  • 25 h-Index
1986 …2020

Research output per year

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Research Output

  • 1936 Citations
  • 25 h-Index
  • 52 Article
  • 7 Review article
  • 4 Chapter
  • 1 Comment/debate
1986

Structure and expression of the human parathyroid hormone gene.

Kronenberg, H. M., Igarashi, T., Freeman, M. W., Okazaki, T., Brand, S. J., Wiren, K. M. & Potts, J. T., Jan 1 1986, In : Recent progress in hormone research. 42, p. 641-663 23 p.

Research output: Contribution to journalReview article

25 Scopus citations
1987

Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence

Freeman, M. W., Wiren, K. M., Rapoport, A., Lazar, M., Potts, J. T. & Kronenberg, H. M., Sep 1987, In : Molecular Endocrinology. 1, 9, p. 628-638 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Preproparathyroid Hormone: A Model for Analyzing the Secretory Pathway

WIREN, KRISTINE. M., FREEMAN, MASON. W., POTTS, JOHN. T. & KRONENBERG, HENRY. M., Apr 1987, In : Annals of the New York Academy of Sciences. 493, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

1988

Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function

Wiren, K. M., Potts, J. T. & Kronenberg, H. M., Dec 1 1988, In : Journal of Biological Chemistry. 263, 36, p. 19771-19777 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
1989

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane binding properties

Wiren, K. M., Ivashkiv, L., Ma, P., Freeman, M. W., Potts, J. T. & Kronenberg, H. M., Feb 1989, In : Molecular Endocrinology. 3, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
1991

Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma

Plymate, S. R., Loop, S. M., Hoop, R. C., Wiren, K. M., Ostenson, R., Hryb, D. J. & Rosner, W., 1991, In : Journal of Steroid Biochemistry and Molecular Biology. 40, 4-6, p. 833-839 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
1992

Functional cloning vectors for use in directional cDNA cloning using cohesive ends produced with T4 DNA polymerase

Kuijper, J. L., Wiren, K. M., Mathies, L. D., Gray, C. L. & Hagen, F. S., Mar 15 1992, In : Gene. 112, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Interaction of nascent preproparathyroid hormone molecules with microsomal membranes

Baba, H., Karaplis, A. C., Wiren, K. M., Keutmann, H. T. & Kronenberg, H. M., Feb 1992, In : Journal of Bone and Mineral Research. 7, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
1993

Regulation of osteoblastic gene expression by lead

Klein, R. F. & Wiren, K. M., Jun 1993, In : Endocrinology. 132, 6, p. 2531-2537 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
1994
78 Scopus citations
1995

Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts

Birnbaum, R. S., Bowsher, R. R. & Wiren, K. M., Jan 1 1995, In : Journal of Endocrinology. 144, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
1996

β-Adrenergic receptor kinase-like activity and β-arrestin are expressed in osteoblastic cells

Bliziotes, M., Murtagh, J. & Wiren, K., Jun 1 1996, In : Journal of Bone and Mineral Research. 11, 6, p. 820-826 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
1997

Transcriptional up-regulation of the human androgen receptor by androgen in bone cells

Wiren, K. M., Zhang, X., Chang, C., Keenan, E. & Orwoll, E. S., Jan 1 1997, In : Endocrinology. 138, 6, p. 2291-2300 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
1998

Identification of neuroendocrine-specific protein as an ethanol- regulated gene with mRNA differential display

Schafer, G. L., Crabbe, J. C. & Wiren, K. M., Dec 1 1998, In : Mammalian Genome. 9, 12, p. 979-982 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
1999

Homologous androgen receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness

Wiren, K., Keenan, E., Zhang, X., Ramsey, B. & Orwoll, E., Jan 1 1999, In : Endocrinology. 140, 7, p. 3114-3124 11 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations
2000

Elevated prodynorphin expression associated with ethanol withdrawal convulsions

Beadles-Bohling, A. S., Crabbe, J. C. & Wiren, K. M., Nov 1 2000, In : Neurochemistry International. 37, 5-6, p. 463-472 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function

Bliziotes, M., Gunness, M., Zhang, X. W., Nissenson, R. & Wiren, K., Sep 1 2000, In : Bone. 27, 3, p. 367-373 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2001

Ethanol-regulated gene expression of neuroendocrine specific protein in mice: Brain region and genotype specificity

Schafer, G. L., Crabbe, J. C. & Wiren, K. M., Apr 6 2001, In : Brain research. 897, 1-2, p. 139-149 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake

Bliziotes, M. M., Eshleman, A. J., Zhang, X. W. & Wiren, K. M., Nov 13 2001, In : Bone. 29, 5, p. 477-486 10 p.

Research output: Contribution to journalArticle

176 Scopus citations

Regulated Nuclear-Cytoplasmic Localization of CCAAT/Enhancer-binding Protein δ in Osteoblasts

Billiard, J., Umayahara, Y., Wiren, K., Centrella, M., McCarthy, T. L. & Rotwein, P., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 15354-15361 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2002

Osteoblast differentiation influences androgen and estrogen receptor-α and -β expression

Wiren, K. M., Evans, A. C. & Zhang, X. W., Dec 1 2002, In : Journal of Endocrinology. 175, 3, p. 683-694 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

The role of dopamine and serotonin in regulating bone mass and strength: Studies on dopamine and serotonin transporter null mice

Bliziotes, M., Gunness, M., Eshleman, A. & Wiren, K., Mar 25 2002, In : Journal of Musculoskeletal Neuronal Interactions. 2, 3, p. 291-295 5 p.

Research output: Contribution to journalReview article

50 Scopus citations
2004

Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts

Wiren, K. M., Toombs, A. R. & Zhang, X. W., Feb 1 2004, In : Journal of molecular endocrinology. 32, 1, p. 209-226 18 p.

Research output: Contribution to journalArticle

27 Scopus citations

Comparison of RiboGreen® and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis

Hashimoto, J. G., Beadles-Bohling, A. S. & Wiren, K. M., Jan 1 2004, In : BioTechniques. 36, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Targeted overexpression of androgen receptor in osteoblasts: Unexpected complex bone phenotype in growing animals

Wiren, K. M., Zhang, X. W., Toombs, A. R., Kasparcova, V., Gentile, M. A., Harada, S. I. & Jepsen, K. J., Jul 1 2004, In : Endocrinology. 145, 7, p. 3507-3522 16 p.

Research output: Contribution to journalArticle

59 Scopus citations
75 Scopus citations
2005

Alcohol effects on central nervous system gene expression in genetic animal models

McBride, W. J., Kerns, R. T., Rodd, Z. A., Strother, W. N., Edenberg, H. J., Hashimoto, J. G., Wiren, K. M. & Miles, M. F., Feb 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity

Beadles-Bohling, A. S. & Wiren, K. M., Jun 7 2005, In : Brain research. 1046, 1-2, p. 77-89 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Androgens and bone growth: It's location, location, location

Wiren, K. M., Dec 2005, In : Current Opinion in Pharmacology. 5, 6 SPEC. ISS., p. 626-632 7 p.

Research output: Contribution to journalReview article

33 Scopus citations

Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine)

Warden, S. J., Bliziotes, M. M., Wiren, K. M., Eshleman, A. J. & Turner, C. H., Oct 20 2005, In : Molecular and Cellular Endocrinology. 242, 1-2, p. 1-9 9 p.

Research output: Contribution to journalReview article

61 Scopus citations
2006

A new look at the 5α-reductase inhibitor finasteride

Finn, D. A., Beadles-Bohling, A. S., Beckley, E. H., Ford, M. M., Gililland, K. R., Gorin-Meyer, R. E. & Wiren, K. M., Mar 1 2006, In : CNS Drug Reviews. 12, 1, p. 53-76 24 p.

Research output: Contribution to journalReview article

113 Scopus citations

Anticonvulsive effects of κ-Opioid receptor modulation in an animal model of ethanol withdrawal

Beadles-Bohling, A. S. & Wiren, K. M., Aug 1 2006, In : Genes, Brain and Behavior. 5, 6, p. 483-496 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Impact of sex: Determination of alcohol neuroadaptation and reinforcement

Wiren, K. M., Hashimoto, J. G., Alele, P. E., Devaud, L. L., Price, K. L., Middaugh, L. D., Grant, K. A. & Finn, D. A., Feb 1 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Osteoblast and osteocyte apoptosis associated with androgen action in bone: Requirement of increased Bax/Bcl-2 ratio

Wiren, K. M., Toombs, A. R., Semirale, A. A. & Zhang, X., May 1 2006, In : Bone. 38, 5, p. 637-651 15 p.

Research output: Contribution to journalArticle

60 Scopus citations

Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Bliziotes, M., Eshleman, A., Burt-Pichat, B., Zhang, X. W., Hashimoto, J., Wiren, K. & Chenu, C., Dec 1 2006, In : Bone. 39, 6, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

90 Scopus citations
2007

Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice

Gorin-Meyer, R. E., Wiren, K. M., Tanchuck, M. A., Long, S. L., Yoneyama, N. & Finn, D. A., May 25 2007, In : Neuroscience. 146, 3, p. 1302-1315 14 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

Androgens and Skeletal Biology: Basic Mechanisms

Wiren, K. M., Dec 1 2008, Osteoporosis, Two-Volume Set. Elsevier Inc., p. 425-449 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Androgens Receptor Expression and Steroid Action in Bone

Wiren, K. M., Dec 1 2008, Principles of Bone Biology, Two-Volume Set. Elsevier Inc., Vol. 2. p. 1001-1023 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Neurotoxic consequences of chronic alcohol withdrawal: Expression profiling reveals importance of gender over withdrawal severity

Hashimoto, J. G. & Wiren, K. M., Apr 1 2008, In : Neuropsychopharmacology. 33, 5, p. 1084-1096 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis. A model for compartment-specific androgen action in the skeleton

Wiren, K. M., Semirale, A. A., Zhang, X. W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B. & Jepsen, K. J., Sep 1 2008, In : Bone. 43, 3, p. 440-451 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C. L., Janowsky, A., Franken, F. H., Wiren, K. M., Hashimoto, J. G., Scibelli, A. C. & Phillips, T. J., Nov 1 2009, In : Genes, Brain and Behavior. 8, 8, p. 758-771 14 p.

Research output: Contribution to journalArticle

53 Scopus citations
14 Scopus citations
2010

Androgens and Bone: Basic Aspects

Wiren, K. M. & Orwoll, E. S., Dec 1 2010, Osteoporosis in Men. Elsevier Inc., p. 295-317 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Signaling pathways implicated in androgen regulation of endocortical bone

Wiren, K. M., Semirale, A. A., Hashimoto, J. G. & Zhang, X. W., Mar 1 2010, In : Bone. 46, 3, p. 710-723 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2011

Androgen Receptor Overexpression Is Neuroprotective in Experimental Stroke

Ayala, P., Uchida, M., Akiyoshi, K., Cheng, J., Hashimoto, J., Jia, T., Ronnekleiv, O. K., Murphy, S. J., Wiren, K. M. & Hurn, P. D., Sep 1 2011, In : Translational Stroke Research. 2, 3, p. 346-357 12 p.

Research output: Contribution to journalReview article

3 Scopus citations

Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

Semirale, A. A., Zhang, X. W. & Wiren, K. M., Jul 1 2011, In : Journal of cellular biochemistry. 112, 7, p. 1773-1786 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

Wiren, K. M., Hashimoto, J. G., Semirale, A. A. & Zhang, X. W., Oct 1 2011, In : Bone. 49, 4, p. 662-672 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Elevated testosterone in females reveals a robust sex difference in altered androgen levels during chronic alcohol withdrawal

Forquer, M. R., Hashimoto, J. G., Roberts, M. L. & Wiren, K. M., Mar 1 2011, In : Alcohol. 45, 2, p. 161-171 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication

Hashimoto, J. G., Forquer, M. R., Tanchuck, M. A., Finn, D. A. & Wiren, K. M., Jan 26 2011, In : Neuroscience. 173, p. 57-75 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

Lebold, K. M., Grant, K. A., Freeman, W. M., Wiren, K. M., Miller, G. W., Kiley, C., Leonard, S. W. & Traber, M. G., Mar 1 2011, In : Alcoholism: Clinical and Experimental Research. 35, 3, p. 474-483 10 p.

Research output: Contribution to journalArticle

8 Scopus citations