Kristine Wiren

Professor Emeritus

  • 1892 Citations
  • 25 h-Index
1986 …2020
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Research Output 1986 2018

  • 1892 Citations
  • 25 h-Index
  • 60 Article
  • 4 Chapter
1986
23 Citations (Scopus)

Structure and expression of the human parathyroid hormone gene.

Kronenberg, H. M., Igarashi, T., Freeman, M. W., Okazaki, T., Brand, S. J., Wiren, K. & Potts, J. T., 1986, In : Recent Progress in Hormone Research. 42, p. 641-663 23 p.

Research output: Contribution to journalArticle

Intracellular Fluid
Protein Precursors
Chromosome Mapping
Molecular Cloning
Post Translational Protein Processing
1987
13 Citations (Scopus)

Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence.

Freeman, M. W., Wiren, K., Rapoport, A., Lazar, M., Potts, J. T. & Kronenberg, H. M., Sep 1987, In : Molecular endocrinology (Baltimore, Md.). 1, 9, p. 628-638 11 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Cell-Free System
Amino Acid Sequence
Microsomes
Proteins

Preproparathyroid hormone. A model for analyzing the secretory pathway.

Wiren, K., Freeman, M. W., Potts, J. T. & Kronenberg, H. M., 1987, In : Annals of the New York Academy of Sciences. 493, p. 43-49 7 p.

Research output: Contribution to journalArticle

Protein Precursors
Secretory Pathway
Protein Sorting Signals
Parathyroid Hormone
Animals
1988
33 Citations (Scopus)

Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function

Wiren, K., Potts, J. T. & Kronenberg, H. M., 1988, In : Journal of Biological Chemistry. 263, 36, p. 19771-19777 7 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Peptides
Protein Precursors
Amino Acids
Complementary DNA
1989
12 Citations (Scopus)

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties

Wiren, K., Ivashkiv, L., Ma, P., Freeman, M. W., Potts, J. T. & Kronenberg, H. M., 1989, In : Molecular Endocrinology. 3, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

Protein Transport
Protein Sorting Signals
Mutation
Membranes
Membrane Proteins
1991
42 Citations (Scopus)

Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma

Plymate, S. R., Loop, S. M., Hoop, R. C., Wiren, K., Ostenson, R., Hryb, D. J. & Rosner, W., 1991, In : Journal of Steroid Biochemistry and Molecular Biology. 40, 4-6, p. 833-839 7 p.

Research output: Contribution to journalArticle

Sex Hormone-Binding Globulin
Carcinoma
Dihydrotestosterone
Albumins
Cells
1992
9 Citations (Scopus)

Functional cloning vectors for use in directional cDNA cloning using cohesive ends produced with T4 DNA polymerase

Kuijper, J. L., Wiren, K., Mathies, L. D., Gray, C. L. & Hagen, F. S., Mar 15 1992, In : Gene. 112, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

Genetic Vectors
DNA-Directed DNA Polymerase
Organism Cloning
Complementary DNA
DNA
4 Citations (Scopus)

Interaction of nascent preproparathyroid hormone molecules with microsomal membranes

Baba, H., Karaplis, A. C., Wiren, K., Keutmann, H. T. & Kronenberg, H. M., Feb 1992, In : Journal of Bone and Mineral Research. 7, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

Membranes
Ribosomes
Puromycin
Peptides
Protein Sorting Signals
1993
38 Citations (Scopus)

Regulation of osteoblastic gene expression by lead

Klein, R. & Wiren, K., Jun 1993, In : Endocrinology. 132, 6, p. 2531-2537 7 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Osteoblasts
Messenger RNA
Alkaline Phosphatase
Lead
1994
78 Citations (Scopus)
Insulin-Like Growth Factor Binding Proteins
Osteoblasts
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 3
Messenger RNA
1995
51 Citations (Scopus)

Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts

Birnbaum, R. S., Bowsher, R. R. & Wiren, K., 1995, In : Journal of Endocrinology. 144, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Osteoblasts
Insulin-Like Growth Factor I
Mitogens
Extracellular Matrix
1996
22 Citations (Scopus)

β-Adrenergic receptor kinase-like activity and β-arrestin are expressed in osteoblastic cells

Bliziotes, M., Murtagh, J. & Wiren, K., Jun 1996, In : Journal of Bone and Mineral Research. 11, 6, p. 820-826 7 p.

Research output: Contribution to journalArticle

Arrestin
Adrenergic Receptors
Phosphotransferases
Rhodopsin
Phosphorylation
1997
81 Citations (Scopus)

Transcriptional up-regulation of the human androgen receptor by androgen in bone cells

Wiren, K., Zhang, X., Chang, C., Keenan, E. & Orwoll, E., 1997, In : Endocrinology. 138, 6, p. 2291-2300 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Up-Regulation
Bone and Bones
Osteoblasts
1998
17 Citations (Scopus)

Identification of neuroendocrine-specific protein as an ethanol- regulated gene with mRNA differential display

Schafer, G. L., Crabbe, J. J. & Wiren, K., 1998, In : Mammalian Genome. 9, 12, p. 979-982 4 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Ethanol
Genes
Proteins
Seizures
1999
28 Citations (Scopus)

Homologous androgen receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness

Wiren, K., Keenan, E., Zhang, X., Ramsey, B. & Orwoll, E., 1999, In : Endocrinology. 140, 7, p. 3114-3124 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Up-Regulation
Dihydrotestosterone
Cell Line
2000
17 Citations (Scopus)

Elevated prodynorphin expression associated with ethanol withdrawal convulsions

Beadles-Bohling, A. S., Crabbe, J. J. & Wiren, K., Nov 1 2000, In : Neurochemistry International. 37, 5-6, p. 463-472 10 p.

Research output: Contribution to journalArticle

Seizures
Ethanol
Glyceraldehyde-3-Phosphate Dehydrogenases
Messenger RNA
preproenkephalin
13 Citations (Scopus)

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function

Bliziotes, M., Gunness, M., Zhang, X. W., Nissenson, R. & Wiren, K., Sep 2000, In : Bone. 27, 3, p. 367-373 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Mitogen-Activated Protein Kinases
Osteoblasts
G-Protein-Coupled Receptor Kinases
Intercellular Signaling Peptides and Proteins
2001
21 Citations (Scopus)

Ethanol-regulated gene expression of neuroendocrine specific protein in mice: Brain region and genotype specificity

Schafer, G. L., Crabbe, J. J. & Wiren, K., Apr 6 2001, In : Brain Research. 897, 1-2, p. 139-149 11 p.

Research output: Contribution to journalArticle

Ethanol
Genotype
Gene Expression
Brain
Seizures
171 Citations (Scopus)

Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake

Bliziotes, M. M., Eshleman, A. J., Zhang, X. W. & Wiren, K., 2001, In : Bone. 29, 5, p. 477-486 10 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Osteoblasts
Neurotransmitter Agents
Serotonin
Receptor, Serotonin, 5-HT2B
28 Citations (Scopus)

Regulated Nuclear-Cytoplasmic Localization of CCAAT/Enhancer-binding Protein δ in Osteoblasts

Billiard, J., Umayahara, Y., Wiren, K., Centrella, M., McCarthy, T. L. & Rotwein, P., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 15354-15361 8 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Osteoblasts
Protein Kinases
Insulin-Like Growth Factor I
Dinoprostone
2002
63 Citations (Scopus)

Osteoblast differentiation influences androgen and estrogen receptor-α and -β expression

Wiren, K., Evans, A. C. & Zhang, X. W., Dec 1 2002, In : Journal of Endocrinology. 175, 3, p. 683-694 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteoblasts
Estrogen Receptors
Estrogens
Androgens
49 Citations (Scopus)

The role of dopamine and serotonin in regulating bone mass and strength: Studies on dopamine and serotonin transporter null mice

Bliziotes, M., Gunness, M., Eshleman, A. & Wiren, K., 2002, In : Journal of Musculoskeletal Neuronal Interactions. 2, 3, p. 291-295 5 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Dopamine
Serotonin
Bone and Bones
2004
27 Citations (Scopus)

Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts

Wiren, K., Toombs, A. R. & Zhang, X. W., Feb 2004, In : Journal of Molecular Endocrinology. 32, 1, p. 209-226 18 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Osteoblasts
Androgens
Phosphotransferases
Androgen Receptor Antagonists
90 Citations (Scopus)

Comparison of RiboGreen® and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis

Hashimoto, J. G., Beadles-Bohling, A. S. & Wiren, K., Jan 2004, In : BioTechniques. 36, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

18S Ribosomal RNA
Online Systems
Online systems
Fluorescence Spectrometry
Gene Expression Profiling
59 Citations (Scopus)

Targeted overexpression of androgen receptor in osteoblasts: Unexpected complex bone phenotype in growing animals

Wiren, K., Zhang, X. W., Toombs, A. R., Kasparcova, V., Gentile, M. A., Harada, S. I. & Jepsen, K. J., Jul 2004, In : Endocrinology. 145, 7, p. 3507-3522 16 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteoblasts
Phenotype
Bone and Bones
Transgenic Mice
75 Citations (Scopus)
Pregnanolone
Behavioral Genetics
Pregnanes
Neurotransmitter Agents
Ethanol
2005
15 Citations (Scopus)

Alcohol effects on central nervous system gene expression in genetic animal models

McBride, W. J., Kerns, R. T., Rodd, Z. A., Strother, W. N., Edenberg, H. J., Hashimoto, J. G., Wiren, K. & Miles, M. F., Feb 2005, In : Alcoholism: Clinical and Experimental Research. 29, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Genetic Models
Neurology
Gene expression
Animals
Ethanol
19 Citations (Scopus)

Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity

Beadles-Bohling, A. S. & Wiren, K., Jun 7 2005, In : Brain Research. 1046, 1-2, p. 77-89 13 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Genetic Models
Seizures
Ethanol
Brain
33 Citations (Scopus)

Androgens and bone growth: It's location, location, location

Wiren, K., Dec 2005, In : Current Opinion in Pharmacology. 5, 6 SPEC. ISS., p. 626-632 7 p.

Research output: Contribution to journalArticle

Bone Development
Androgens
Bone and Bones
Androgen Receptors
Osteoclasts
60 Citations (Scopus)

Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine)

Warden, S. J., Bliziotes, M. M., Wiren, K., Eshleman, A. J. & Turner, C. H., Oct 20 2005, In : Molecular and Cellular Endocrinology. 242, 1-2, p. 1-9 9 p.

Research output: Contribution to journalArticle

Serotonin
Bone
Bone and Bones
Metabolism
Skeleton
2006
109 Citations (Scopus)

A new look at the 5α-reductase inhibitor finasteride

Finn, D. D., Beadles-Bohling, A. S., Beckley, E. H., Ford, M., Gililland, K. R., Gorin-Meyer, R. E. & Wiren, K., Mar 2006, In : CNS Drug Reviews. 12, 1, p. 53-76 24 p.

Research output: Contribution to journalArticle

Finasteride
Oxidoreductases
Steroids
20-alpha-Dihydroprogesterone
Protein Isoforms
20 Citations (Scopus)

Anticonvulsive effects of κ-Opioid receptor modulation in an animal model of ethanol withdrawal

Beadles-Bohling, A. S. & Wiren, K., Aug 2006, In : Genes, Brain and Behavior. 5, 6, p. 483-496 14 p.

Research output: Contribution to journalArticle

Opioid Receptors
Seizures
Ethanol
Animal Models
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
28 Citations (Scopus)

Impact of sex: Determination of alcohol neuroadaptation and reinforcement

Wiren, K., Hashimoto, J. G., Alele, P. E., Devaud, L. L., Price, K. L., Middaugh, L. D., Grant, K. K. & Finn, D. D., Feb 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

Reinforcement
Ethanol
Alcohols
Sex Characteristics
Self Administration
59 Citations (Scopus)

Osteoblast and osteocyte apoptosis associated with androgen action in bone: Requirement of increased Bax/Bcl-2 ratio

Wiren, K., Toombs, A. R., Semirale, A. A. & Zhang, X., May 2006, In : Bone. 38, 5, p. 637-651 15 p.

Research output: Contribution to journalArticle

Osteocytes
Osteoblasts
Androgens
Apoptosis
Dihydrotestosterone
87 Citations (Scopus)

Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Bliziotes, M., Eshleman, A., Burt-Pichat, B., Zhang, X. W., Hashimoto, J., Wiren, K. & Chenu, C., Dec 2006, In : Bone. 39, 6, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Serotonin Receptors
Serotonin
Receptor, Serotonin, 5-HT2A
Osteocytes
2007
28 Citations (Scopus)

Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice

Gorin-Meyer, R. E., Wiren, K., Tanchuck, M. A., Long, S. L., Yoneyama, N. & Finn, D. D., May 25 2007, In : Neuroscience. 146, 3, p. 1302-1315 14 p.

Research output: Contribution to journalArticle

Finasteride
Inbred DBA Mouse
Sex Characteristics
Ethanol
Pregnanolone
2008
1 Citation (Scopus)

Androgens and Skeletal Biology: Basic Mechanisms

Wiren, K., 2008, Osteoporosis, Two-Volume Set. Elsevier Inc., p. 425-449 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Androgens
3 Citations (Scopus)

Androgens Receptor Expression and Steroid Action in Bone

Wiren, K., 2008, Principles of Bone Biology, Two-Volume Set. Elsevier Inc., Vol. 2. p. 1001-1023 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Androgen Receptors
Androgens
Bone
Steroids
Bone and Bones
49 Citations (Scopus)

Neurotoxic consequences of chronic alcohol withdrawal: Expression profiling reveals importance of gender over withdrawal severity

Hashimoto, J. G. & Wiren, K., Apr 2008, In : Neuropsychopharmacology. 33, 5, p. 1084-1096 13 p.

Research output: Contribution to journalArticle

Ethanol
Alcohols
Alcoholism
Brain
Cell Death
45 Citations (Scopus)

Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis. A model for compartment-specific androgen action in the skeleton

Wiren, K., Semirale, A. A., Zhang, X. W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B. & Jepsen, K. J., Sep 2008, In : Bone. 43, 3, p. 440-451 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Osteogenesis
Skeleton
Androgens
Bone and Bones
2009
49 Citations (Scopus)

Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C., Janowsky, A., Franken, F. H., Wiren, K., Hashimoto, J. G., Scibelli, A. C. & Phillips, T., Nov 2009, In : Genes, Brain and Behavior. 8, 8, p. 758-771 14 p.

Research output: Contribution to journalArticle

Methamphetamine
Self Administration
Pharmaceutical Preparations
Genes
Gene Expression
14 Citations (Scopus)
Pregnanolone
Enzyme activity
Oxidoreductases
Ethanol
Seizures
2010
1 Citation (Scopus)

Androgens and Bone: Basic Aspects

Wiren, K. & Orwoll, E., 2010, Osteoporosis in Men. Elsevier Inc., p. 295-317 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Androgens
Bone
Bone and Bones
Androgen Receptors
Steroid hormones
14 Citations (Scopus)

Signaling pathways implicated in androgen regulation of endocortical bone

Wiren, K., Semirale, A. A., Hashimoto, J. G. & Zhang, X. W., Mar 2010, In : Bone. 46, 3, p. 710-723 14 p.

Research output: Contribution to journalArticle

Androgens
Bone and Bones
Androgen Receptors
Osteoblasts
Bone Morphogenetic Proteins
2011
3 Citations (Scopus)

Androgen Receptor Overexpression Is Neuroprotective in Experimental Stroke

Ayala, P., Uchida, M., Akiyoshi, K., Cheng, J., Hashimoto, J., Jia, T., Ronnekleiv, O., Murphy, S. J., Wiren, K. & Hurn, P. D., Sep 2011, In : Translational Stroke Research. 2, 3, p. 346-357 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Stroke
Dihydrotestosterone
Middle Cerebral Artery Infarction
PC12 Cells
25 Citations (Scopus)

Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

Semirale, A. A., Zhang, X. W. & Wiren, K., Jul 2011, In : Journal of Cellular Biochemistry. 112, 7, p. 1773-1786 14 p.

Research output: Contribution to journalArticle

Cell Lineage
Body Composition
Stem cells
Androgens
Stem Cells
12 Citations (Scopus)

Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

Wiren, K., Hashimoto, J. G., Semirale, A. A. & Zhang, X. W., Oct 2011, In : Bone. 49, 4, p. 662-672 11 p.

Research output: Contribution to journalArticle

Neural Crest
Frontal Bone
Osteoblasts
Adipocytes
Androgens
11 Citations (Scopus)

Elevated testosterone in females reveals a robust sex difference in altered androgen levels during chronic alcohol withdrawal

Forquer, M. R., Hashimoto, J. G., Roberts, M. L. & Wiren, K., Mar 2011, In : Alcohol. 45, 2, p. 161-171 11 p.

Research output: Contribution to journalArticle

Sex Characteristics
withdrawal
Androgens
Testosterone
Seizures
19 Citations (Scopus)

Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication

Hashimoto, J. G., Forquer, M. R., Tanchuck, M. A., Finn, D. D. & Wiren, K., Jan 26 2011, In : Neuroscience. 173, p. 57-75 19 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Prefrontal Cortex
Seizures
Gene Expression
Recurrence
8 Citations (Scopus)

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

Lebold, K. M., Grant, K. K., Freeman, W. M., Wiren, K., Miller, G. W., Kiley, C., Leonard, S. W. & Traber, M. G., Mar 2011, In : Alcoholism: Clinical and Experimental Research. 35, 3, p. 474-483 10 p.

Research output: Contribution to journalArticle

Self Administration
Macaca fascicularis
Hyperlipidemias
Vitamin E
Individuality