Kirsten Lampi

Professor

  • 1728 Citations
  • 23 h-Index
1988 …2019

Research output per year

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Research Output

  • 1728 Citations
  • 23 h-Index
  • 42 Article
  • 2 Review article
2019

Altered Protein Dynamics and Increased Aggregation of Human γs-Crystallin Due to Cataract-Associated Deamidations

Forsythe, H. M., Vetter, C. J., Jara, K. A., Reardon, P. N., David, L. L., Barbar, E. J. & Lampi, K. J., Oct 8 2019, In : Biochemistry. 58, 40, p. 4112-4124 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Murein hydrolase LytF of Streptococcus sanguinis and the ecological consequences of competence development

Cullin, N., Redanz, S., Lampi, K., Merritt, J. & Kreth, J., Dec 1 2017, In : Applied and Environmental Microbiology. 83, 24, e01709-17.

Research output: Contribution to journalArticle

4 Scopus citations

The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function

Posner, M., Murray, K. L., McDonald, M. S., Eighinger, H., Andrew, B., Drossman, A., Haley, Z., Nussbaum, J., David, L. & Lampi, K., Jan 1 2017, In : PeerJ. 2017, 11, 4093.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Differences in solution dynamics between lens β-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation

Lampi, K. J., Murray, M. R., Peterson, M. P., Eng, B. S., Yue, E., Clark, A. R., Barbar, E. & David, L. L., Jan 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 1, p. 304-314 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014
53 Scopus citations
2012
7 Scopus citations
2011

New focus on alpha-crystallins in retinal neurodegenerative diseases

Fort, P. E. & Lampi, K. J., Feb 1 2011, In : Experimental Eye Research. 92, 2, p. 98-103 6 p.

Research output: Contribution to journalReview article

46 Scopus citations
2010

Aggregation of deamidated human βB2-crystallin and incomplete rescue by α-crystallin chaperone

Michiel, M., Duprat, E., Skouri-Panet, F., Lampi, J. A., Tardieu, A., Lampi, K. J. & Finet, S., Jun 1 2010, In : Experimental Eye Research. 90, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Solvent accessibility of βB2-crystallin and local structural changes due to deamidation at the dimer interface

Takata, T., Smith, J. P., Arbogast, B., David, L. L. & Lampi, K. J., Sep 1 2010, In : Experimental Eye Research. 91, 3, p. 336-346 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Ubiquitin proteasome pathway-mediated degradation of proteins: Effects due to site-specific substrate deamidation

Dudek, E. J., Lampi, K. J., Lampi, J. A., Shang, F., King, J., Wang, Y. & Taylor, A., Aug 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 8, p. 4164-4173 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Deamidation alters interactions of β-crystallins in hetero-oligomers

Takata, T., Woodbury, L. G. & Lampi, K. J., Jan 28 2009, In : Molecular vision. 15, p. 241-249 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

Associations of seroreactivity against crystallin proteins with disease activity and cataract in patients with uveitis

Chen, L., Holland, G. N., Yu, F., Levinson, R. D., Lampi, K. J., Horwitz, J. & Gordon, L. K., Oct 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 10, p. 4476-4481 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin

Takata, T., Oxford, J. T., Demeler, B. & Lampi, K. J., Sep 1 2008, In : Protein Science. 17, 9, p. 1565-1575 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Tissue transglutaminase catalyzes the deamidation of glutamines in lens βB2- and βB3-crystallins

Boros, S., Wilmarth, P. A., Kamps, B., de Jong, W. W., Bloemendal, H., Lampi, K. & Boelens, W. C., Feb 1 2008, In : Experimental Eye Research. 86, 2, p. 383-393 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2007

Age-related changes of alpha-crystallin aggregate in human lens

Fujii, N., Shimmyo, Y., Sakai, M., Sadakane, Y., Nakamura, T., Morimoto, Y., Kinouchi, T., Goto, Y. & Lampi, K., Jan 1 2007, In : Amino Acids. 32, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Deamidation alters the structure and decreases the stability of human lens βA3-crystallin

Takata, T., Oxford, J. T., Brandon, T. R. & Lampi, K. J., Jul 31 2007, In : Biochemistry. 46, 30, p. 8861-8871 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Differential binding of mutant (R116C) and wildtype alphaA crystallin to actin

Brown, Z., Ponce, A., Lampi, K., Hancock, L. & Takemoto, L., Dec 1 2007, In : Current Eye Research. 32, 12, p. 1051-1054 4 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

Deamidation in human lens βB2-crystallin destabilizes the dimer

Lampi, K. J., Amyx, K. K., Ahmann, P. & Steel, E. A., Mar 14 2006, In : Biochemistry. 45, 10, p. 3146-3153 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Measurement of deamidation of intact proteins by isotopic envelope and mass defect with ion cyclotron resonance Fourier transform mass spectrometry

Robinson, N. E., Zabrouskov, V., Zhang, J., Lampi, K. J. & Robinson, A. B., Dec 12 2006, In : Rapid Communications in Mass Spectrometry. 20, 23, p. 3535-3541 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Quantitative measurement of young human eye lens crystallins by direct injection Fourier transform ion cyclotron resonance mass spectrometry

Robinson, N. E., Lampi, K. J., Speir, J. P., Kruppa, G., Easterling, M. & Robinson, A. B., Jun 21 2006, In : Molecular vision. 12, p. 704-711 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2005

Quantitative measurement of deamidation in lens βB2-crystallin and peptides by direct electrospray injection and fragmentation in a Fourier transform mass spectrometer

Robinson, N. E., Lampi, K. J., McIver, R. T., Williams, R. H., Muster, W. C., Kruppa, G. & Robinson, A. B., Dec 28 2005, In : Molecular vision. 11, p. 1211-1219 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2004

Laser light-scattering evidence for an altered association of βB1-crystallin deamidated in the connecting peptide

Harms, M. J., Wilmarth, P. A., Kapfer, D. M., Steel, E. A., David, L. L., Bächinger, H. P. & Lampi, K. J., Mar 1 2004, In : Protein Science. 13, 3, p. 678-686 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2003

Beta B1-crystallin: Identification of a candidate ciliary body uveitis antigen

Stempel, D., Sandusky, H., Lampi, K., Cilluffo, M., Horwitz, J., Braun, J., Goodglick, L. & Gordon, L. K., Jan 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 1, p. 203-209 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

A nonsense mutation in CRYBB1 associated with autosomal dominant cataract linked to human chromosome 22q

Mackay, D. S., Boskovska, O. B., Knopf, H. L. S., Lampi, K. J. & Shiels, A., Jan 1 2002, In : American Journal of Human Genetics. 71, 5, p. 1216-1221 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Deamidation, but not truncation, decreases the urea stability of a lens structural protein, βB1-crystallin

Kim, Y. H., Kapfer, D. M., Boekhorst, J., Lubsen, N. H., Bächinger, H. P., Shearer, T. R., David, L. L., Feix, J. B. & Lampi, K. J., Nov 26 2002, In : Biochemistry. 41, 47, p. 14076-14084 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Decreased heat stability and increased chaperone requirement of modified human βB1-crystallins

Lampi, K. J., Kim, Y. H., Bächinger, H. P., Boswell, B. A., Lindner, R. A., Carver, J. A., Shearer, T. R., David, L. L. & Kapfer, D. M., Dec 1 2002, In : Molecular vision. 8, p. 359-366 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Lens proteomics: Analysis of rat crystallin sequences and two-dimensional electrophoresis map

Lampi, K. J., Shih, M., Ueda, Y., Shearer, T. R. & David, L. L., Jan 15 2002, In : Investigative Ophthalmology and Visual Science. 43, 1, p. 216-224 9 p.

Research output: Contribution to journalArticle

84 Scopus citations
2001

Deamidation of human βB1 alters the elongated structure of the dimer

Lampi, K. J., Oxford, J. T., Bachinger, H. P., Shearer, T. R., David, L. L. & Kapfer, D. M., Jan 1 2001, In : Experimental Eye Research. 72, 3, p. 279-288 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Importance of nutrition for optimum health of the periodontium

Boyd, L. D. & Lampi, K. J., Jan 1 2001, In : Journal of Contemporary Dental Practice. 2, 2, p. 23-36 14 p.

Research output: Contribution to journalReview article

10 Scopus citations

Proteolysis by m-calpain enhances in vitro light scattering by crystallins from human and bovine lenses

Shih, M., David, L. L., Lampi, K. J., Ma, H., Fukiage, C., Azuma, M. & Shearer, T. R., Dec 1 2001, In : Current Eye Research. 22, 6, p. 458-469 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
1998

Age-related changes in human lens crystallins identified by HPLC and mass spectrometry

Ma, Z., Hanson, S. R. A., Lampi, K. J., David, L. L., Smith, D. L. & Smith, J. B., Jul 1998, In : Experimental Eye Research. 67, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

147 Scopus citations

Age-related changes in human lens crystallins identified by two- dimensional electrophoresis and mass spectrometry

Lampi, K. J., Ma, Z., Hanson, S. R. A., Azuma, M., Shih, M., Shearer, T. R., Smith, D. L., Smith, J. B. & David, L. L., Jul 1998, In : Experimental Eye Research. 67, 1, p. 31-43 13 p.

Research output: Contribution to journalArticle

205 Scopus citations

Cleavage of beta crystallins during maturation of bovine lens.

Shih, M., Lampi, K. J., Shearer, T. R. & David, L. L., Feb 27 1998, In : Molecular vision. 4, 1 p.

Research output: Contribution to journalArticle

36 Scopus citations
1997

Sequence analysis of βA3, βB3, and βA4 crystallins completes the identification of the major proteins in young human lens

Lampi, K. J., Ma, Z., Shih, M., Shearer, T. R., Smith, J. B., Smith, D. L. & David, L. L., Jan 1 1997, In : Journal of Biological Chemistry. 272, 4, p. 2268-2275 8 p.

Research output: Contribution to journalArticle

162 Scopus citations
1996

Human βB1-crystallin is partially degraded at its N-terminal extension during lens maturation

David, L. L., Lampi, K. J., Lund, A. L. & Smith, J. B., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S420

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
1992

Association of calpain with insoluble pellet of rat lens

Lampi, K. J., David, L. L. & Shearer, T. R., Aug 1992, In : Experimental Eye Research. 55, 2, p. 369-375 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses

Lampi, K. J., Kadoya, K., Azuma, M., David, L. L. & Shearer, T. R., Nov 1992, In : Toxicology and Applied Pharmacology. 117, 1, p. 53-57 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
1991

Increased thromboxane production in recalcified challenged whole blood from copper-deficient rats

Allen, K. G. D., Lampi, K. J., Bostwick, P. J. & Mathias, M. M., Jan 1991, In : Nutrition Research. 11, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
1989

Calpain II in human lens

David, L. L., Varnum, M. D., Lampi, K. J. & Shearer, T. R., Jan 1 1989, In : Investigative Ophthalmology and Visual Science. 30, 2, p. 269-275 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
1988

Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

Lampi, K. J., Mathias, M. M., Rengers, B. D. & Allen, K. G. D., Oct 1988, In : Nutrition Research. 8, 10, p. 1191-1202 12 p.

Research output: Contribution to journalArticle

8 Scopus citations