Kent Thornburg

Professor

  • 7843 Citations
  • 43 h-Index
1972 …2020
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Research Output 1972 2019

2019

30th anniversary for the developmental origins of endocrinology

Limesand, S. W., Thornburg, K. & Harding, J. E., Jan 1 2019, In : Journal of Endocrinology. 242, 1, p. E1-E4

Research output: Contribution to journalReview article

Open Access
Endocrinology
Anniversaries and Special Events

Activator protein-1 and caspase 8 mediate p38α MAPK-dependent cardiomyocyte apoptosis induced by palmitic acid

Oh, C. C., Lee, J., D’Souza, K., Zhang, W., Migrino, R. Q., Thornburg, K. & Reaven, P., Jan 1 2019, In : Apoptosis.

Research output: Contribution to journalArticle

Palmitic Acid
Caspase 8
Transcription Factor AP-1
p38 Mitogen-Activated Protein Kinases
Cardiac Myocytes
Virus Integration
Oxidative Phosphorylation
Cardiac Myocytes
Down-Regulation
Glycolysis
3 Citations (Scopus)

Research Recommendations From the National Institutes of Health Workshop on Predicting, Preventing, and Treating Preeclampsia

Maric-Bilkan, C., Abrahams, V. M., Arteaga, S. S., Bourjeily, G., Conrad, K. P., Catov, J. M., Costantine, M. M., Cox, B., Garovic, V., George, E. M., Gernand, A. D., Jeyabalan, A., Karumanchi, S. A., Laposky, A. D., Miodovnik, M., Mitchell, M., Pemberton, V. L., Reddy, U. M., Santillan, M. K., Tsigas, E. & 4 others, Thornburg, K., Ward, K., Myatt, L. & Roberts, J. M., Apr 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 4, p. 757-766 10 p.

Research output: Contribution to journalArticle

National Institutes of Health (U.S.)
Pre-Eclampsia
Education
Research

Right ventricular remodeling in response to volume overload in fetal sheep

Karamlou, T., Giraud, G., McKeogh, D., Jonker, S., Shen, I., Ungerleider, R. M. & Thornburg, K., May 1 2019, In : American journal of physiology. Heart and circulatory physiology. 316, 5, p. H985-H991

Research output: Contribution to journalArticle

Ventricular Remodeling
Cardiac Myocytes
Sheep
Fetus
Heart Ventricles
1 Citation (Scopus)
Thyroid Hormone Receptors
Cardiac Myocytes
Sheep
Somatomedins
Bromodeoxyuridine
2018
14 Citations (Scopus)

A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes

Barbour, L. A., Scifres, C., Valent, A. M., Friedman, J. E., Buchanan, T. A., Coustan, D., Aagaard, K., Thornburg, K., Catalano, P. M., Galan, H. L., Hay, W. W., Frias, A., Shankar, K., Simmons, R. A., Moses, R. G., Sacks, D. A. & Loeken, M. R., Jan 1 2018, (Accepted/In press) In : American Journal of Obstetrics and Gynecology.

Research output: Contribution to journalArticle

Gestational Diabetes
Metformin
Pharmacology
Glyburide
Insulin
1 Citation (Scopus)

Effects of prenatal nutrition and the role of the placenta in health and disease

Myatt, L. & Thornburg, K., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1735. p. 19-46 28 p. (Methods in Molecular Biology; vol. 1735).

Research output: Chapter in Book/Report/Conference proceedingChapter

Placenta
Health
Food
Epidemiologic Studies
Fetus
3 Citations (Scopus)

Impact of maternal obesity and breastfeeding intention on lactation intensity and duration

Marshall, N., Lau, B., Purnell, J. & Thornburg, K., Jan 1 2018, (Accepted/In press) In : Maternal and Child Nutrition. e12732.

Research output: Contribution to journalArticle

Breast Feeding
Lactation
Obesity
Mothers
Body Mass Index
6 Citations (Scopus)

Inflammatory determinants of pregravid obesity in placenta and peripheral blood

Sureshchandra, S., Marshall, N., Wilson, R. M., Barr, T., Rais, M., Purnell, J., Thornburg, K. & Messaoudi, I., Aug 7 2018, In : Frontiers in Physiology. 9, AUG, 1089.

Research output: Contribution to journalArticle

Placenta
Obesity
Chemokines
Cytokines
Inflammation
1 Citation (Scopus)

Prenatal Development and Adolescent Obesity: Two Distinct Pathways to Diabetes in Adulthood

Heinonen, J., Sacks, R. M., Takemoto, E. E., Hooker, E. R., Dieckmann, N., Harrod, C. S. & Thornburg, K., Apr 1 2018, In : Childhood Obesity. 14, 3, p. 173-181 9 p.

Research output: Contribution to journalArticle

Pediatric Obesity
Body Mass Index
Birth Weight
Prediabetic State
Longitudinal Studies

Real-time microscopic assessment of fatty acid uptake kinetics in the human term placenta

Kolahi, K. S., Valent, A. M. & Thornburg, K., Dec 1 2018, In : Placenta. 72-73, p. 1-9 9 p.

Research output: Contribution to journalArticle

Placenta
Fatty Acids
Trophoblasts
Fetal Development
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
1 Citation (Scopus)

The Maternal Nutritional Milieu and Neonatal Outcomes: Connecting the Dots

Thornburg, K. & Valent, A. M., Jan 1 2018, (Accepted/In press) In : Journal of Pediatrics.

Research output: Contribution to journalArticle

Mothers
2017
15 Citations (Scopus)

Blood flow patterns underlie developmental heart defects

Midgett, M., Thornburg, K. & Rugonyi, S., Mar 13 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 3, p. H632-H642

Research output: Contribution to journalArticle

Congenital Heart Defects
Embryonic Structures
Double Outlet Right Ventricle
Branchial Region
Teratogens
10 Citations (Scopus)

Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta

Kolahi, K. S., Valent, A. M. & Thornburg, K., Feb 23 2017, In : Scientific Reports. 7, 42941.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Trophoblasts
Glycolysis
Placenta
DNA

IFPA meeting 2016 workshop report III: Decidua-trophoblast interactions; trophoblast implantation and invasion; immunology at the maternal-fetal interface; placental inflammation

Aplin, J. D., Beristain, A., DaSilva-Arnold, S., Dunk, C., Duzyj, C., Golos, T. G., Kemmerling, U., Knöfler, M., Mitchell, M. D., Olson, D. M., Petroff, M., Pollheimer, J., Reyes, L., Schedin, P., Soares, M. J., Stencel-Baerenwald, J., Thornburg, K. & Lash, G. E., Apr 13 2017, (Accepted/In press) In : Placenta.

Research output: Contribution to journalArticle

Decidua
Trophoblasts
Allergy and Immunology
Mothers
Inflammation
5 Citations (Scopus)

International summit on the nutrition of adolescent girls and young women: consensus statement

Krebs, N., Bagby, S., Bhutta, Z. A., Dewey, K., Fall, C., Gregory, F., Hay, W., Rhuman, L., Caldwell, C. W. & Thornburg, K., Jul 1 2017, In : Annals of the New York Academy of Sciences. 1400, 1, p. 3-7 5 p.

Research output: Contribution to journalComment/debate

Nutrition
Nutrients
Health
Adolescent Girls
Food
8 Citations (Scopus)

Maternal pregravid obesity remodels the DNA methylation landscape of cord blood monocytes disrupting their inflammatory program

Sureshchandra, S., Wilson, R. M., Rais, M., Marshall, N., Purnell, J., Thornburg, K. & Messaoudi, I., Oct 15 2017, In : Journal of Immunology. 199, 8, p. 2729-2744 16 p.

Research output: Contribution to journalArticle

DNA Methylation
Fetal Blood
Monocytes
Obesity
Mothers
5 Citations (Scopus)

Maternal weight gain regulates omega-3 fatty acids in male, not female, neonates: A cross-sectional study

O'Tierney-Ginn, P. F., Gillingham, M., Fowler, J., Brass, E., Marshall, N. & Thornburg, K., 2017, In : Reproductive Sciences. 24, 4, p. 560-567 8 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Weight Gain
Cross-Sectional Studies
Mothers
Unsaturated Fatty Acids
10 Citations (Scopus)

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

Lue, H. W., Podolak, J., Kolahi, K., Cheng, L., Rao, S., Garg, D., Xue, C. H., Rantala, J. K., Tyner, J., Thornburg, K., Martinez-Acevedo, A., Liu, J-J., Amling, C., Truillet, C., Louie, S. M., Anderson, K. E., Evans, M. J., O’Donnell, V. B., Nomura, D. K., Drake, J. M. & 2 others, Ritz, A. & Thomas, G., Oct 15 2017, In : Genes and Development. 31, 20, p. 2067-2084 18 p.

Research output: Contribution to journalArticle

Cell Survival
Autophagy
Phospholipases A2
Oxidative Phosphorylation
Neoplasms
1 Citation (Scopus)

Neonatal fatty acid profiles are correlated with infant growth measures at 6 months

O’Tierney-Ginn, P. F., Davina, D., Gillingham, M., Barker, D. J. P., Morris, C. & Thornburg, K., Mar 16 2017, (Accepted/In press) In : Journal of Developmental Origins of Health and Disease. p. 1-9 9 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Fatty Acids
Body Mass Index
Parturition
Weight Gain
30 Citations (Scopus)

Nutrition in adolescents: physiology, metabolism, and nutritional needs

Das, J. K., Salam, R. A., Thornburg, K., Prentice, A. M., Campisi, S., Lassi, Z. S., Koletzko, B. & Bhutta, Z. A., Apr 1 2017, In : Annals of the New York Academy of Sciences. 1393, 1, p. 21-33 13 p.

Research output: Contribution to journalReview article

Physiology
Nutrition
Metabolism
Availability
Economics
3 Citations (Scopus)

Poorer maternal diet quality and increased birth weight*

Grandy, M., Snowden, J., Heinonen, J., Purnell, J., Thornburg, K. & Marshall, N., May 17 2017, (Accepted/In press) In : Journal of Maternal-Fetal and Neonatal Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Birth Weight
Mothers
Diet
Weight Gain
Adiposity

REGULATION AND CONTROL IN PHYSIOLOGICAL SYSTEMS.

Faber, J. J., Gault, C. F., Green, T. J., Thornburg, K., Jaffrin, M. Y., Raines, J. K., Lucas, T. R., Srinivasan, S., Tamalonis, A., Ateyeh, E. C., Sawyer, P. N. & Moss, G., Jan 1 2017.

Research output: Contribution to conferencePaper

Cardiovascular system
Stabilization
2 Citations (Scopus)

The neuropeptide galanin promotes an anti-thrombotic phenotype on endocardial endothelial cells from heart failure patients

Tyrrell, C., Toyooka, A., Khan, F., Thornburg, K., Mudd, J. & Hasan, W., Sep 1 2017, In : Autonomic Neuroscience: Basic and Clinical. 206, p. 35-42 8 p.

Research output: Contribution to journalArticle

Galanin
Neuropeptides
Endothelial Cells
Heart Failure
Phenotype
3 Citations (Scopus)

Thyroid hormone and pancreas development: diabetes culprit or innocent bystander?

Thornburg, K. & Chattergoon, N., Jun 1 2017, In : Journal of Physiology. 595, 11, p. 3261 1 p.

Research output: Contribution to journalArticle

Insulin-Secreting Cells
Thyroid Hormones
Pancreas
Diabetes Mellitus
Fetus
2016

A chicken embryo cardiac outflow tract atlas for registering changes due to abnormal blood flow

Carson, J. P., Rennie, M. Y., Danilchik, M., Thornburg, K. & Rugonyi, S., Oct 13 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., Vol. 2016-October. p. 1236-1239 4 p. 7590929

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Atlases
Chickens
Blood
Embryonic Structures
Congenital Heart Defects
40 Citations (Scopus)

A review of fundamental principles for animal models of DOHaD research: An Australian perspective

Dickinson, H., Moss, T. J., Gatford, K. L., Moritz, K. M., Akison, L., Fullston, T., Hryciw, D. H., Maloney, C. A., Morris, M. J., Wooldridge, A. L., Schjenken, J. E., Robertson, S. A., Waddell, B. J., Mark, P. J., Wyrwoll, C. S., Ellery, S. J., Thornburg, K., Muhlhausler, B. S. & Morrison, J. L., Oct 1 2016, In : Journal of Developmental Origins of Health and Disease. 7, 5, p. 449-472 24 p.

Research output: Contribution to journalReview article

Animal Models
Health
Research
New Zealand
Animal Disease Models
11 Citations (Scopus)

Biological features of placental programming

Thornburg, K., Kolahi, K., Pierce, M., Valent, A., Drake, R. & Louey, S., Dec 1 2016, In : Placenta. 48, p. S47-S53

Research output: Contribution to journalArticle

Placenta
Fetal Development
Fetus
Chronic Disease
Placental Insufficiency
2 Citations (Scopus)

Changes in dynamic embryonic heart wall motion in response to outflow tract banding measured using video densitometry

Stovall, S., Midgett, M., Thornburg, K. & Rugonyi, S., Nov 1 2016, In : Journal of Biomedical Optics. 21, 11, 116003.

Research output: Contribution to journalArticle

blood flow
Optical microscopy
biodynamics
microscopy
heart diseases
12 Citations (Scopus)

Comparison of multiple methods to measure maternal fat mass in late gestation

Marshall, N., Murphy, E. J., King, J. C., Haas, E. K., Lim, J. Y., Wiedrick, J., Thornburg, K. & Purnell, J., Apr 1 2016, In : American Journal of Clinical Nutrition. 103, 4, p. 1055-1063 9 p.

Research output: Contribution to journalArticle

Fats
Mothers
Pregnancy
Skinfold Thickness
Plethysmography
20 Citations (Scopus)

Developmental Origins, Epigenetics, and Equity: Moving Upstream

Wallack, L. & Thornburg, K., May 1 2016, In : Maternal and Child Health Journal. 20, 5, p. 935-940 6 p.

Research output: Contribution to journalArticle

Epigenomics
Social Responsibility
Health
Hope
Genetic Code

Furosemide Pharmacokinetics in Adult Rats become Abnormal with an Adverse Intrauterine Environment and Modulated by a Post-Weaning High-Fat Diet

Dubois, B. N., Pearson, J., Mahmood, T., Thornburg, K. & Cherala, G., Jun 1 2016, In : Basic and Clinical Pharmacology and Toxicology. 118, 6, p. 432-439 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Furosemide
High Fat Diet
Nutrition
Weaning
3 Citations (Scopus)

Long-term cardiovascular outcome following fetal anaemia and intrauterine transfusion: A cohort study

Wallace, A. H., Dalziel, S. R., Cowan, B. R., Young, A. A., Thornburg, K. & Harding, J. E., Sep 23 2016, (Accepted/In press) In : Archives of Disease in Childhood.

Research output: Contribution to journalArticle

Intrauterine Blood Transfusion
Anemia
Cohort Studies
Perfusion
Heart Rate
98 Citations (Scopus)

Placental origins of chronic disease

Burton, G. J., Fowden, A. L. & Thornburg, K., Oct 1 2016, In : Physiological Reviews. 96, 4, p. 1509-1565 57 p.

Research output: Contribution to journalArticle

Fetus
Chronic Disease
Placenta
Fetal Development
Mothers
3 Citations (Scopus)

Prenatal and maternal characteristics and later risk for coronary heart disease among women

Eriksson, J. G., Kajantie, E., Thornburg, K. & Osmond, C., Mar 1 2016, In : European Journal of Preventive Cardiology. 23, 4, p. 385-390 6 p.

Research output: Contribution to journalArticle

Coronary Disease
Mothers
Birth Weight
Parturition
Nuclear Family
14 Citations (Scopus)
Trophoblasts
long chain fatty acids
placenta
Placenta
Fatty Acids

Wombs with a view: Illustrations of the gravid uterus from the renaissance through the nineteenth century

Longo, L. D., Reynolds, L. P., Thornburg, K. & Spong, C. Y., Jan 1 2016, Springer International Publishing. 380 p.

Research output: Book/ReportBook

Social Responsibility
Placenta
Uterus
Reproduction
Fetus
2015
8 Citations (Scopus)

Endocardial endothelial dysfunction progressively disrupts initially anti then pro-thrombotic pathways in heart failure mice

Schoner, A., Tyrrell, C., Wu, M., Gelow, J., Hayes, A. A., Lindner, J., Thornburg, K. & Hasan, W., Nov 1 2015, In : PLoS One. 10, 11, e0142940.

Research output: Contribution to journalArticle

heart failure
Heart Failure
Thrombosis
mice
von Willebrand Factor
4 Citations (Scopus)

From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity

Heinonen, J., Messer, L. C., Fortmann, S. P., Wallack, L. & Thornburg, K., Dec 1 2015, In : Preventive Medicine. 81, p. 451-459 9 p.

Research output: Contribution to journalArticle

Fetal Development
Chronic Disease
Obesity
Mothers
Exercise
3 Citations (Scopus)

IFPA meeting 2015 workshop report: Mechanistic role of the placenta in fetal programming; biomarkers of placental function and complications of pregnancy; late onset fetal growth restriction surveillance and monitoring

Andraweera, P. H., Bobek, G., Bowen, C., Burton, G. J., Correa Frigerio, P., Chaparro, A., Dickinson, H., Duncombe, G., Hyett, J., Illanes, S. E., Johnstone, E., Kumar, S., Morgan, T., Myers, J., Orefice, R., Roberts, C. T., Salafia, C. M., Thornburg, K., Whitehead, C. L. & Bainbridge, S. A., Oct 14 2015, (Accepted/In press) In : Placenta.

Research output: Contribution to journalArticle

Pregnancy Complications
Fetal Development
Placenta
Biomarkers
Education
7 Citations (Scopus)

Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction

Barry, J. S., Rozance, P. J., Brown, L. D., Anthony, R. V., Thornburg, K. & Hay, W. W., 2015, In : Experimental Biology and Medicine. 241, 8, p. 839-847 9 p.

Research output: Contribution to journalArticle

Fetal Development
Metabolism
Insulin Resistance
Sheep
Insulin
Heart Valves
Fetal Development
Aortic Valve
Mitral Valve
Sheep
19 Citations (Scopus)

Influence of high fat diet and resveratrol supplementation on placental fatty acid uptake in the Japanese macaque

O'Tierney-Ginn, P., Roberts, V., Gillingham, M., Walker, J., Glazebrook, P. A., Thornburg, K., Grove, K. & Frias, A., Aug 1 2015, In : Placenta. 36, 8, p. 903-910 8 p.

Research output: Contribution to journalArticle

Macaca
High Fat Diet
Fatty Acids
AMP-Activated Protein Kinases
Acids

Letter to Hiroko Nishimura

Thornburg, K., Sep 1 2015, In : Physiologist. 58, 5, p. 271 1 p.

Research output: Contribution to journalArticle

Biomedical Research
22 Citations (Scopus)

Maternal obesity alters immune cell frequencies and responses in umbilical cord blood samples

Wilson, R. M., Marshall, N., Jeske, D. R., Purnell, J., Thornburg, K. & Messaoudi, I., Jun 1 2015, In : Pediatric Allergy and Immunology. 26, 4, p. 344-351 8 p.

Research output: Contribution to journalArticle

Fetal Blood
Obesity
Mothers
Immune System
Asthma
6 Citations (Scopus)

Overcoming birth weight: Can physical activity mitigate birth weight-related differences in adiposity?

Heinonen, J., Markwardt, S., Fortmann, S. P. & Thornburg, K., 2015, (Accepted/In press) In : Pediatric obesity.

Research output: Contribution to journalArticle

Adiposity
Birth Weight
Exercise
Waist Circumference
Body Mass Index
25 Citations (Scopus)

The placenta is the center of the chronic disease universe

Thornburg, K. & Marshall, N., Oct 1 2015, In : American Journal of Obstetrics and Gynecology. 213, 4, p. S14-S20

Research output: Contribution to journalArticle

Chorioamnionitis
Organ Size
Fetal Development
Birth Weight
Placenta
34 Citations (Scopus)

The programming of cardiovascular disease

Thornburg, K., May 13 2015, In : Journal of Developmental Origins of Health and Disease. 6, 5, p. 366-376 11 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Epigenomics
Nephrons
Health
DNA Methylation
2 Citations (Scopus)

The relationship between umbilical cord length and chronic rheumatic heart disease: A prospective cohort study

Goodman, A., Kajantie, E., Osmond, C., Eriksson, J., Koupil, I., Thornburg, K. & Phillips, D. I., Sep 12 2015, In : European Journal of Preventive Cardiology. 22, 9, p. 1154-1160 7 p.

Research output: Contribution to journalArticle

Rheumatic Heart Disease
Umbilical Cord
Cohort Studies
Prospective Studies
Parturition