Ke-Zhong Shen

Research Assistant Professor

  • 2617 Citations
  • 28 h-Index
1989 …2019
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Research Output 1989 2019

  • 2617 Citations
  • 28 h-Index
  • 56 Article
2019

Phosphoinositol metabolism affects AMP kinase-dependent K-ATP currents in rat substantia nigra dopamine neurons

Shen, K-Z., Munhall, A. C. & Johnson, S., Mar 1 2019, In : Brain Research. 1706, p. 32-40 9 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Dopaminergic Neurons
Substantia Nigra
Diazoxide
Type C Phospholipases
2017
3 Citations (Scopus)
Adenylate Kinase
Ventral Tegmental Area
Herpes Zoster
Diazoxide
A 769662
2016
5 Citations (Scopus)

AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons

Shen, K-Z., Wu, Y. N., Munhall, A. C. & Johnson, S., Aug 25 2016, In : Neuroscience. 330, p. 219-228 10 p.

Research output: Contribution to journalArticle

Diazoxide
Adenylate Kinase
Dopaminergic Neurons
Substantia Nigra
AMP-Activated Protein Kinases
2014
15 Citations (Scopus)

AMP kinase regulates K-ATP currents evoked by NMDA receptor stimulation in rat subthalamic nucleus neurons

Shen, K-Z., Yakhnitsa, V., Munhall, A. C. & Johnson, S., Aug 22 2014, In : Neuroscience. 274, p. 138-152 15 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Subthalamic Nucleus
Adenosine Monophosphate
Adenosine Triphosphate
Neurons
2013
6 Citations (Scopus)
Subthalamus
Adenosine Triphosphate
Neurons
Subthalamic Nucleus
Cyclic GMP-Dependent Protein Kinases
2012
5 Citations (Scopus)
Subthalamic Nucleus
Dopamine
Adenosine Triphosphate
Neurons
Oxidopamine
1 Citation (Scopus)
Subthalamic Nucleus
Baclofen
Neurons
Action Potentials
Parkinson Disease
7 Citations (Scopus)
Excitatory Postsynaptic Potentials
Dopamine Receptors
Herpes Zoster
Subthalamic Nucleus
Dopamine
2010
30 Citations (Scopus)
N-Methylaspartate
Subthalamic Nucleus
Nitric Oxide
Adenosine Triphosphate
Neurons
2008
21 Citations (Scopus)

5-HT inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro

Shen, K-Z. & Johnson, S., Feb 19 2008, In : Neuroscience. 151, 4, p. 1029-1033 5 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Synaptic Transmission
Serotonin
Neurons
Inhibitory Postsynaptic Potentials
13 Citations (Scopus)
Subthalamic Nucleus
Neurons
Action Potentials
Parkinson Disease
Deep Brain Stimulation
2007
17 Citations (Scopus)

Multiple conductances are modulated by 5-HT receptor subtypes in rat subthalamic nucleus neurons

Shen, K-Z., Kozell, L. B. & Johnson, S., Sep 21 2007, In : Neuroscience. 148, 4, p. 996-1003 8 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Serotonin Receptors
Serotonin
Neurons
Aspartic Acid
2006
35 Citations (Scopus)

Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro

Shen, K-Z. & Johnson, S., Jun 15 2006, In : Journal of Physiology. 573, 3, p. 697-709 13 p.

Research output: Contribution to journalArticle

Excitatory Postsynaptic Potentials
Subthalamic Nucleus
Neurons
Parkinson Disease
In Vitro Techniques
2005
42 Citations (Scopus)

Dopamine depletion alters responses to glutamate and GABA in the rat subthalamic nucleus

Shen, K-Z. & Johnson, S., Feb 8 2005, In : NeuroReport. 16, 2, p. 171-174 4 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
gamma-Aminobutyric Acid
Glutamic Acid
Dopamine
Oxidopamine
18 Citations (Scopus)

NMDA enhances a depolarization-activated inward current in subthalamic neurons

Zhu, Z. T., Munhall, A., Shen, K-Z. & Johnson, S., Sep 2005, In : Neuropharmacology. 49, 3, p. 317-327 11 p.

Research output: Contribution to journalArticle

Aspartic Acid
Subthalamic Nucleus
Transient Receptor Potential Channels
Neurons
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
2004
50 Citations (Scopus)
N-Methylaspartate
Calcium
Neurons
Subthalamic Nucleus
Mibefradil
2003
21 Citations (Scopus)

Dopamine receptor supersensitivity in rat subthalamus after 6-hydroxydopamine lesions

Shen, K-Z., Zhu, Z. T., Munhall, A. & Johnson, S., Dec 2003, In : European Journal of Neuroscience. 18, 11, p. 2967-2974 8 p.

Research output: Contribution to journalArticle

Subthalamus
Subthalamic Nucleus
Oxidopamine
Dopamine Receptors
Dopamine
13 Citations (Scopus)
Subthalamic Nucleus
Metabotropic Glutamate Receptors
Excitatory Postsynaptic Potentials
Protein Kinase C
LY 341495
18 Citations (Scopus)

Presynaptic inhibition of synaptic transmission by adenosine in rat subthalamic nucleus in vitro

Shen, K-Z. & Johnson, S., Jan 15 2003, In : Neuroscience. 116, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Excitatory Postsynaptic Potentials
Synaptic Transmission
Adenosine
Inhibitory Postsynaptic Potentials
76 Citations (Scopus)

Synaptic Plasticity in Rat Subthalamic Nucleus Induced by High-Frequency Stimulation

Shen, K-Z., Zhu, Z. T., Munhall, A. & Johnson, S., Dec 15 2003, In : Synapse. 50, 4, p. 314-319 6 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Neuronal Plasticity
Synaptic Potentials
Neurons
Deep Brain Stimulation
2002
64 Citations (Scopus)

Excitatory effects of dopamine on subthalamic nucleus neurons: In vitro study of rats pretreated with 6-hydroxydopamine and levodopa

Zhu, Z., Bartol, M., Shen, K-Z. & Johnson, S., Jul 26 2002, In : Brain Research. 945, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Oxidopamine
Levodopa
Dopamine
Neurons
44 Citations (Scopus)

Pharmacological identification of inward current evoked by dopamine in rat subthalamic neurons in vitro

Zhu, Z. T., Shen, K-Z. & Johnson, S., 2002, In : Neuropharmacology. 42, 6, p. 772-781 10 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Dopamine
Pharmacology
Neurons
GTP-Binding Proteins
31 Citations (Scopus)

Presynaptic modulation of synaptic transmission by opioid receptor in rat subthalamic nucleus in vitro

Shen, K-Z. & Johnson, S., May 15 2002, In : Journal of Physiology. 541, 1, p. 219-230 12 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Methionine Enkephalin
Opioid Receptors
Synaptic Transmission
D-Penicillamine (2,5)-Enkephalin
2001
9 Citations (Scopus)
GABA Uptake Inhibitors
GABA-A Receptor Agonists
Mesencephalon
Arginine
gamma-Aminobutyric Acid
20 Citations (Scopus)

Presynaptic GABAB receptors inhibit synaptic inputs to rat subthalamic neurons

Shen, K-Z. & Johnson, S., Dec 18 2001, In : Neuroscience. 108, 3, p. 431-436 6 p.

Research output: Contribution to journalArticle

Presynaptic Receptors
Baclofen
Inhibitory Postsynaptic Potentials
Excitatory Postsynaptic Potentials
Neurons
2000
112 Citations (Scopus)
Muscarine
Dopamine
Inhibitory Concentration 50
gamma-Aminobutyric Acid
Neurons
1999
26 Citations (Scopus)
Baclofen
Dopaminergic Neurons
Mesencephalon
N-Methyl-D-Aspartate Receptors
N-Methylaspartate
1998
7 Citations (Scopus)

Aromatic residues affecting permeation and gating in dSlo BK channels

Lagrutta, A. A., Shen, K-Z., Rivard, A., North, R. A. & Adelman, J., 1998, In : Pflugers Archiv European Journal of Physiology. 435, 5, p. 731-739 9 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Tetraethylammonium
Permeation
Mutation
Electric potential
17 Citations (Scopus)

Sodium pump evokes high density pump currents in rat midbrain dopamine neurons

Shen, K-Z. & Johnson, S., Oct 15 1998, In : Journal of Physiology. 512, 2, p. 449-457 9 p.

Research output: Contribution to journalArticle

Strophanthidin
Sodium-Potassium-Exchanging ATPase
Dopaminergic Neurons
Mesencephalon
Ventral Tegmental Area
1997
10 Citations (Scopus)

L-arginine potentiates GABA-mediated synaptic transmission by a nitric oxide-independent mechanism in rat dopamine neurons

Shen, K-Z., Cox, B. A. & Johnson, S., May 26 1997, In : Neuroscience. 79, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Synaptic Transmission
gamma-Aminobutyric Acid
Arginine
Nitric Oxide
76 Citations (Scopus)
Adenosine A1 Receptors
Synaptic Transmission
Adenosine
gamma-Aminobutyric Acid
Baclofen
1996
38 Citations (Scopus)

3α-hydroxy-3β-trifluoromethyl-5α-pregnan-20-one (Co 2-1970): A partial agonist at the neuroactive steroid site of the γ-Aminobutyric acidA receptor

Hawkinson, J. E., Drewe, J. A., Kimbrough, C. L., Chen, J. S., Hogenkamp, D. J., Lan, N. C., Gee, K. W., Shen, K-Z., Whittemore, E. R. & Woodward, R. M., May 1996, In : Molecular Pharmacology. 49, 5, p. 897-906 10 p.

Research output: Contribution to journalArticle

Steroids
Flunitrazepam
GABA-A Receptors
gamma-Aminobutyric Acid
Muscimol
32 Citations (Scopus)

Inhibition of morphine tolerance by NMDA receptor antagonists in the formalin test

Lutfy, K., Shen, K-Z., Woodward, R. M. & Weber, E., Aug 26 1996, In : Brain Research. 731, 1-2, p. 171-181 11 p.

Research output: Contribution to journalArticle

Pain Measurement
N-Methyl-D-Aspartate Receptors
Morphine
Dizocilpine Maleate
Glutamate Receptors
27 Citations (Scopus)

Pharmacology of ACEA-1416: A potent systemically active NMDA receptor glycine site antagonist

Ilyin, V. I., Whittemore, E. R., Tran, M., Shen, K-Z., Cai, S. X., Kher, S. M., Keana, J. F. W., Weber, E. & Woodward, R. M., Aug 29 1996, In : European Journal of Pharmacology. 310, 2-3, p. 107-114 8 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Glycine
Pharmacology
Oocytes
AMPA Receptors
24 Citations (Scopus)

Sulfonylurea-sensitive potassium current evoked by sodium-loading in rat midbrain dopamine neurons

Seutin, V., Shen, K-Z., North, R. A. & Johnson, S., Apr 1996, In : Neuroscience. 71, 3, p. 709-719 11 p.

Research output: Contribution to journalArticle

Diazoxide
Dopaminergic Neurons
Mesencephalon
Potassium
Sodium
1995
45 Citations (Scopus)

Blockade of morphine tolerance by ACEA-1328, a novel NMDA receptor/glycine site antagonist

Lutfy, K., Shen, K-Z., Kwon, I. S., Cai, S. X., Woodward, R. M., Keana, J. F. W. & Weber, E., Jan 24 1995, In : European Journal of Pharmacology. 273, 1-2, p. 187-189 3 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Glycine
Morphine
Tail
ACEA 1328
1994
148 Citations (Scopus)

Functional differences among alternatively spliced variants of Slowpoke, a Drosophila calcium-activated potassium channel

Lagrutta, A., Shen, K-Z., North, R. A. & Adelman, J., Aug 12 1994, In : Journal of Biological Chemistry. 269, 32, p. 20347-20351 5 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Drosophila
Oocytes
Large-Conductance Calcium-Activated Potassium Channels
Calcium
154 Citations (Scopus)

Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: Evidence for tetrameric channel formation

Shen, K-Z., Lagrutta, A., Davies, N. W., Standen, N. B., Adelman, J. & North, R. A., Mar 1994, In : Pflügers Archiv European Journal of Physiology. 426, 5, p. 440-445 6 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Tetraethylammonium
Xenopus
Oocytes
Tyrosine
1993
36 Citations (Scopus)

Common ionic mechanisms of excitation by substance P and other transmitters in guinea-pig submucosal neurones

Shen, K-Z. & Surprenant, A., 1993, In : Journal of Physiology. 462, p. 483-501 19 p.

Research output: Contribution to journalArticle

Substance P
Potassium
Guinea Pigs
Neurons
Muscarine
82 Citations (Scopus)

Excitation of rat locus coeruleus neurons by adenosine 5′-triphosphate: Ionic mechanism and receptor characterization

Shen, K-Z. & North, R. A., 1993, In : Journal of Neuroscience. 13, 3, p. 894-899 6 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Adenosine Triphosphate
Neurons
Ions
Sodium
29 Citations (Scopus)

Somatostatin-mediated inhibitory postsynaptic potential in sympathetically denervated guinea-pig submucosal neurones

Shen, K-Z. & Surprenant, A., 1993, In : Journal of Physiology. 470, p. 619-635 17 p.

Research output: Contribution to journalArticle

Inhibitory Postsynaptic Potentials
Somatostatin
Guinea Pigs
Neurons
seglitide
1992
154 Citations (Scopus)

5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala

Sugita, S., Shen, K-Z. & North, R. A., 1992, In : Neuron. 8, 1, p. 199-203 5 p.

Research output: Contribution to journalArticle

Serotonin 5-HT3 Receptor Antagonists
Receptors, Serotonin, 5-HT3
Synaptic Potentials
Amygdala
Serotonin
413 Citations (Scopus)

Calcium-activated potassium channels expressed from cloned complementary DNAs

Adelman, J., Shen, K-Z., Kavanaugh, M. P., Warren, R. A., Wu, Y. N., Lagrutta, A., Bond, C. T. & Alan North, R., 1992, In : Neuron. 9, 2, p. 209-216 8 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Complementary DNA
Calcium
Potassium Channels
Alternative Splicing
75 Citations (Scopus)

Muscarine increases cation conductance and decreases potassium conductance in rat locus coeruleus neurones

Shen, K-Z. & North, R. A., 1992, In : Journal of Physiology. 455, p. 471-485 15 p.

Research output: Contribution to journalArticle

Muscarine
Locus Coeruleus
Cations
Potassium
Neurons
41 Citations (Scopus)

Potassium channels opened by noradrenaline and other transmitters in excised membrane patches of guinea-pig submucosal neurones

Shen, K-Z., North, R. A. & Surprenant, A., 1992, In : Journal of Physiology. 445, p. 581-599 19 p.

Research output: Contribution to journalArticle

Potassium Channels
Tandem Pore Domain Potassium Channels
Enkephalins
Norepinephrine
Guinea Pigs
108 Citations (Scopus)

Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons

Shen, K-Z. & North, R. A., 1992, In : Neuroscience. 50, 2, p. 345-353 9 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Potassium Channels
Substance P
Cations
Neurons
1991
22 Citations (Scopus)
N-Type Calcium Channels
Barium
Calcium Channels
Somatostatin
Opioid Analgesics

Observations on single ion channels affected by inhibitory transmitters in guinea pig submucous plexus neurones

Shen, K-Z., Surprenant, A. & North, R. A., May 1 1991, In : Journal of the Autonomic Nervous System. 33, 2, p. 157 1 p.

Research output: Contribution to journalArticle

Submucous Plexus
Ion Channels
Guinea Pigs
Neurons
18 Citations (Scopus)

Transmitter regulation of voltage-dependant K+ channels expressed in Xenopus oocytes

Kavanaugh, M. P., Christie, M. J., Osborne, P. B., Busch, A. E., Shen, K-Z., Wu Seeburg, Y. N. P. H., Adelman, J. & North, R. A., 1991, In : Biochemical Journal. 277, 3, p. 899-902 4 p.

Research output: Contribution to journalArticle

Xenopus
Oocytes
Transmitters
Serotonin
Electric potential
1990
55 Citations (Scopus)

Cation current activated by hyperpolarization (I(H)) in guinea pig enteric neurons

Galligan, J. J., Tatsumi, H., Shen, K-Z., Surprenant, A. & North, R. A., 1990, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 259, 6 22-6

Research output: Contribution to journalArticle

Cations
Guinea Pigs
Neurons
Membrane Potentials
Potassium