Kathleen (Kathy) Grant

Professor

  • 7713 Citations
  • 45 h-Index
1978 …2020
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Research Output 1980 2019

2019

A comparative study of the pharmacokinetics of clozapine N-oxide and clozapine N-oxide hydrochloride salt in rhesus macaques

Allen, D. C., Carlson, T. L., Xiong, Y., Jin, J., Grant, K. K. & Cuzon Carlson, V., Feb 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 2, p. 199-207 9 p.

Research output: Contribution to journalArticle

Macaca mulatta
Pharmacokinetics
Salts
Dimethyl Sulfoxide
Clozapine
2 Citations (Scopus)

Chronic alcohol drinking slows brain development in adolescent and young adult nonhuman primates

Shnitko, T., Liu, Z., Wang, X., Grant, K. K. & Kroenke, C. C., Mar 1 2019, In : eNeuro. 6, 2, e0044-19.2019.

Research output: Contribution to journalArticle

Open Access
Adolescent Development
Alcohol Drinking
Primates
Young Adult
Brain

Chronic ethanol consumption alters lamina propria leukocyte response to stimulation in a region-dependent manner

Barr, T., Lewis, S. A., Sureshchandra, S., Doratt, B., Grant, K. K. & Messaoudi, I., Jun 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 7767-7777 11 p.

Research output: Contribution to journalArticle

Mucous Membrane
Leukocytes
Ethanol
Drinking
Alcohols
1 Citation (Scopus)

Chronic ethanol drinking increases during the luteal menstrual cycle phase in rhesus monkeys: implication of progesterone and related neurosteroids

Dozier, B., Stull, C. A., Baker, E. J., Ford, M., Jensen, J. P., Finn, D. D. & Grant, K. K., Jan 1 2019, (Accepted/In press) In : Psychopharmacology.

Research output: Contribution to journalArticle

Luteal Phase
Macaca mulatta
Drinking
Progesterone
Neurotransmitter Agents

Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages

Sureshchandra, S., Stull, C., Ligh, B. J. K., Nguyen, S. B., Grant, K. K. & Messaoudi, I., Jan 1 2019, In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
Macrophages
Epigenomics
Alcohol Drinking
Drinking
Alcohols

Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys

Bogenpohl, J. W., Smith, M. L., Farris, S. P., Dumur, C. I., Lopez, M. F., Becker, H. C., Grant, K. K. & Miles, M. F., Aug 13 2019, In : Frontiers in Molecular Neuroscience. 12, 197.

Research output: Contribution to journalArticle

Open Access
Prefrontal Cortex
Transcriptome
Haplorhini
Ethanol
Gene Regulatory Networks

Detecting Neurodevelopmental Effects of Early-Gestation Ethanol Exposure: A Nonhuman Primate Model of Ethanol Drinking During Pregnancy

Jimenez, V. A., Wang, X., Newman, N., Walter, N. A. R., Gonzales, S., Lo, J., Ford, M., Cuzon Carlson, V., Grant, K. K. & Kroenke, C. C., Jan 1 2019, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Primates
Drinking
Ethanol
Alcohols
Pregnancy
Macaca mulatta
Metabolism
Drug therapy
Ethanol
Dizocilpine Maleate

Dose-dependent effects of chronic alcohol drinking on peripheral immune responses

Sureshchandra, S., Raus, A., Jankeel, A., Ligh, B. J. K., Walter, N. A. R., Newman, N., Grant, K. K. & Messaoudi, I., Dec 1 2019, In : Scientific Reports. 9, 1, 7847.

Research output: Contribution to journalArticle

Open Access
Alcohol Drinking
Drinking
Blood Cells
Self Administration
Macaca mulatta
2 Citations (Scopus)

Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation

Collaborative Initiative on Fetal Alcohol Spectrum Disorders, Jan 1 2019, In : Life Science Alliance. 2, 2, e201800252.

Research output: Contribution to journalArticle

Open Access
Fetal Alcohol Spectrum Disorders
MicroRNAs
maturation
alcohol
Epithelial-Mesenchymal Transition
G-Protein-Coupled Receptors
Primates
Ethanol
Alcohols
Nucleus Accumbens
2018
6 Citations (Scopus)

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: Preliminary translational findings across rats, monkeys and humans

Aoun, E. G., Jimenez, V. A., Vendruscolo, L. F., Walter, N. A. R., Barbier, E., Ferrulli, A., Haass-Koffler, C. L., Darakjian, P., Lee, M. R., Addolorato, G., Heilig, M., Hitzemann, R., Koob, G. F., Grant, K. K. & Leggio, L., Jun 1 2018, In : Molecular Psychiatry. 23, 6, p. 1466-1473 8 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptors
Aldosterone
Alcohol Drinking
Haplorhini
Ethanol
6 Citations (Scopus)

Concurrent gut transcriptome and microbiota profiling following chronic ethanol consumption in nonhuman primates

Barr, T., Sureshchandra, S., Ruegger, P., Zhang, J., Ma, W., Borneman, J., Grant, K. K. & Messaoudi, I., Apr 19 2018, (Accepted/In press) In : Gut Microbes. p. 1-19 19 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Primates
Colorectal Neoplasms
Ethanol
Alcoholic Liver Diseases
1 Citation (Scopus)

Cross-species molecular dissection across alcohol behavioral domains

Farris, S. P., Riley, B. P., Williams, R. W., Mulligan, M. K., Miles, M. F., Lopez, M. F., Hitzemann, R., Iancu, O., Colville, A., Walter, N. A. R., Darakjian, P., Oberbeck, D. L., Daunais, J. B., Zheng, C., Searles, R., McWeeney, S., Grant, K. K. & Mayfield, R. D., Nov 1 2018, In : Alcohol. 72, p. 19-31 13 p.

Research output: Contribution to journalReview article

Dissection
alcohol
Alcohols
Alcoholism
Phenotype
3 Citations (Scopus)

Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol

Allen, D. C., Ford, M. & Grant, K. K., Jan 1 2018, Current Topics in Behavioral Neurosciences. Springer Verlag, p. 95-111 17 p. (Current Topics in Behavioral Neurosciences; vol. 39).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ethanol
Laboratory Animals
Optogenetics
GABA Receptors
Glutamate Receptors
4 Citations (Scopus)

Low cognitive flexibility as a risk for heavy alcohol drinking in non-human primates

Shnitko, T., Gonzales, S. W. & Grant, K. K., Jan 1 2018, (Accepted/In press) In : Alcohol.

Research output: Contribution to journalArticle

Alcohol Drinking
Primates
flexibility
alcohol
Alcohols
2 Citations (Scopus)
Pregnanolone
Macaca fascicularis
Chemokine CCL2
Hippocampus
Ethanol

Preface

Grant, K. K. & Lovinger, D. M., Jan 1 2018, In : Handbook of Experimental Pharmacology. 248, p. v-vii

Research output: Contribution to journalEditorial

SNARE Complex-Associated Proteins in the Lateral Amygdala of Macaca mulatta Following Long-Term Ethanol Drinking

Alexander, N. J., Rau, A. R., Jimenez, V. A., Daunais, J. B., Grant, K. K. & Mccool, B. A., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

SNARE Proteins
Amygdala
Macaca mulatta
Drinking
Ethanol

Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys

Jimenez, V. A., Herman, M. A., Cuzon Carlson, V., Walter, N. A., Grant, K. K. & Roberto, M., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Paraventricular Hypothalamic Nucleus
Macaca mulatta
Ethanol
Self Administration
Neurons
8 Citations (Scopus)

Synaptic adaptations to chronic ethanol intake in male rhesus monkey dorsal striatum depend on age of drinking onset

Cuzon Carlson, V., Grant, K. K. & Lovinger, D. M., Mar 15 2018, In : Neuropharmacology. 131, p. 128-142 15 p.

Research output: Contribution to journalArticle

Inhibitory Postsynaptic Potentials
Macaca mulatta
Age of Onset
Putamen
Drinking
2017
5 Citations (Scopus)
Desoxycorticosterone
Self Administration
Macaca fascicularis
Ethanol
Appointments and Schedules
14 Citations (Scopus)

Alcohol-dose-dependent DNA methylation and expression in the nucleus accumbens identifies coordinated regulation of synaptic genes

Cervera-Juanes, R., Wilhelm, L. J., Park, B., Grant, K. K. & Ferguson, B., Jan 1 2017, In : Translational Psychiatry. 7, 1, 2016266.

Research output: Contribution to journalArticle

Nucleus Accumbens
DNA Methylation
Methylation
Alcohols
Genes
8 Citations (Scopus)

Effect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey

Allen, D. C., Gonzales, S. W. & Grant, K. K., Oct 19 2017, (Accepted/In press) In : Psychopharmacology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Self Administration
Macaca mulatta
Ethanol
Drinking
Alcohols
14 Citations (Scopus)
First Pregnancy Trimester
Fetal Development
Growth and Development
Primates
Perfusion
13 Citations (Scopus)

Identifying Future Drinkers: Behavioral Analysis of Monkeys Initiating Drinking to Intoxication is Predictive of Future Drinking Classification

Baker, E. J., Walter, N. A. R., Salo, A., Rivas Perea, P., Moore, S., Gonzales, S. & Grant, K. K., 2017, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Drinking
Haplorhini
Ethanol
Alcohols
Binge Drinking
9 Citations (Scopus)

On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome

Iancu, O., Colville, A., Walter, N. A. R., Darakjian, P., Oberbeck, D. L., Daunais, J. B., Zheng, C., Searles, R., McWeeney, S., Grant, K. K. & Hitzemann, R., 2017, (Accepted/In press) In : Addiction Biology.

Research output: Contribution to journalArticle

Macaca mulatta
Transcriptome
Self Administration
Ethanol
Brain
13 Citations (Scopus)

Orbitofrontal neuroadaptations and cross-species synaptic biomarkers in heavy-drinking macaques

Nimitvilai, S., Uys, J. D., Woodward, J. J., Randall, P. K., Ball, L. E., Williams, R. W., Jones, B. C., Lu, L., Grant, K. K. & Mulholland, P. J., Mar 29 2017, In : Journal of Neuroscience. 37, 13, p. 3646-3660 15 p.

Research output: Contribution to journalArticle

Macaca
Drinking
Biomarkers
Prefrontal Cortex
Haplorhini
4 Citations (Scopus)

Ranking cognitive flexibility in a group setting of rhesus monkeys with a set-shifting procedure

Shnitko, T., Allen, D. C., Gonzales, S. W., Walter, N. A. R. & Grant, K. K., Mar 23 2017, In : Frontiers in Behavioral Neuroscience. 11, 55.

Research output: Contribution to journalArticle

Macaca mulatta
Haplorhini
Aptitude
Social Isolation
Executive Function
2 Citations (Scopus)

Social setting, social rank and HPA axis response in cynomolgus monkeys

Jimenez, V. A., Allen, D. C., McClintick, M. N. & Grant, K. K., Mar 22 2017, (Accepted/In press) In : Psychopharmacology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Macaca fascicularis
Hydrocortisone
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Naloxone
13 Citations (Scopus)

Studies using macaque monkeys to address excessive alcohol drinking and stress interactions

Jimenez, V. A. & Grant, K. K., Feb 15 2017, (Accepted/In press) In : Neuropharmacology.

Research output: Contribution to journalArticle

Macaca
Alcohol Drinking
Haplorhini
Primates
Alcohols
2016
4 Citations (Scopus)

Aggressive temperament predicts ethanol self-administration in late adolescent male and female rhesus macaques

McClintick, M. N. & Grant, K. K., Dec 1 2016, In : Psychopharmacology. 233, 23-24, p. 3965-3976 12 p.

Research output: Contribution to journalArticle

Self Administration
Temperament
Macaca mulatta
Ethanol
Haplorhini
31 Citations (Scopus)

Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton

Gaddini, G. W., Turner, R. T., Grant, K. K. & Iwaniec, U. T., 2016, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Skeleton
Nutrients
Bone
Bone Remodeling
Alcohols
11 Citations (Scopus)

Alcohol consumption modulates host defense in rhesus macaques by altering gene expression in circulating leukocytes

Barr, T., Girke, T., Sureshchandra, S., Nguyen, C., Grant, K. K. & Messaoudi, I., Jan 1 2016, In : Journal of Immunology. 196, 1, p. 182-195 14 p.

Research output: Contribution to journalArticle

Macaca mulatta
Alcohol Drinking
Leukocytes
Ethanol
Gene Expression
11 Citations (Scopus)

Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core

Siciliano, C. A., Calipari, E. S., Yorgason, J. T., Mateo, Y., Helms, C., Lovinger, D. M., Grant, K. K. & Jones, S. R., Jan 1 2016, In : Drug and Alcohol Dependence. 158, p. 159-163 5 p.

Research output: Contribution to journalArticle

Self Administration
Nucleus Accumbens
Macaca
Dopamine
Ethanol
7 Citations (Scopus)

Electrical coupling and synchronized subthreshold oscillations in the inferior olive of the Rhesus Macaque

Turecek, J., Han, V. Z., Cuzon Carlson, V., Grant, K. K. & Welsh, J. P., Jun 15 2016, In : Journal of Neuroscience. 36, 24, p. 6497-6502 6 p.

Research output: Contribution to journalArticle

Macaca
Macaca mulatta
Primates
Neurons
Membranes
20 Citations (Scopus)

Functional imaging of the nonhuman primate Placenta with endogenous blood oxygen level–dependent contrast

Schabel, M., Roberts, V., Lo, J., Platt, S., Grant, K. K., Frias, A. & Kroenke, C. C., Nov 1 2016, In : Magnetic Resonance in Medicine. 76, 5, p. 1551-1562 12 p.

Research output: Contribution to journalArticle

Macaca mulatta
Placenta
Primates
Oxygen
Arteries
10 Citations (Scopus)

Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking

Cervera-Juanes, R., Wilhelm, L. J., Park, B., Grant, K. K. & Ferguson, B., Sep 19 2016, (Accepted/In press) In : Alcohol.

Research output: Contribution to journalArticle

Methylation
Nucleus Accumbens
DNA Methylation
Alcohol Drinking
Genes
8 Citations (Scopus)

Increased levels of the acetaldehyde-derived DNA adduct N2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol

Balbo, S., Juanes, R. C., Khariwala, S., Baker, E. J., Daunais, J. B. & Grant, K. K., Sep 1 2016, In : Mutagenesis. 31, 5, p. 553-558 6 p.

Research output: Contribution to journalArticle

Acetaldehyde
DNA Adducts
Mouth Mucosa
Macaca mulatta
Alcohols
18 Citations (Scopus)

Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques

Siciliano, C. A., Calipari, E. S., Yorgason, J. T., Lovinger, D. M., Mateo, Y., Jimenez, V. A., Helms, C., Grant, K. K. & Jones, S. R., Feb 19 2016, (Accepted/In press) In : Psychopharmacology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Self Administration
Nucleus Accumbens
Macaca
Synaptic Transmission
Dopamine
32 Citations (Scopus)

Opposing effects of alcohol on the immune system

Barr, T., Helms, C., Grant, K. K. & Messaoudi, I., Feb 4 2016, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 65, p. 242-251 10 p.

Research output: Contribution to journalArticle

Immune System
Alcohols
Alcohol Drinking
Virus Diseases
Bacterial Infections
50 Citations (Scopus)

The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala

Grayson, D. S., Bliss-Moreau, E., Machado, C. J., Bennett, J., Shen, K., Grant, K. K., Fair, D. & Amaral, D. G., Jul 20 2016, In : Neuron. 91, 2, p. 453-466 14 p.

Research output: Contribution to journalArticle

Connectome
Pharmacogenetics
Amygdala
Macaca mulatta
Brain
8 Citations (Scopus)

Transcriptome profiling reveals disruption of innate immunity in chronic heavy ethanol consuming female rhesus macaques

Sureshchandra, S., Rais, M., Stull, C., Grant, K. K. & Messaoudi, I., Jul 1 2016, In : PLoS One. 11, 7, e0159295.

Research output: Contribution to journalArticle

Gene Expression Profiling
Macaca mulatta
transcriptomics
Innate Immunity
Ethanol
2015
11 Citations (Scopus)

An ultrastructural analysis of the effects of ethanol self-administration on the hypothalamic paraventricular nucleus in rhesus macaques

Jimenez, V. A., Helms, C., Cornea, A., Meshul, C. K. & Grant, K. K., Jul 14 2015, In : Frontiers in Cellular Neuroscience. 9, JULY, 260.

Research output: Contribution to journalArticle

Self Administration
Paraventricular Hypothalamic Nucleus
Macaca mulatta
Ethanol
Arginine Vasopressin
21 Citations (Scopus)

Brain pathways to recovery from alcohol dependence

Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M., Matochik, J., Crews, F. T., Chandler, L. J., Pfefferbaum, A., Becker, H. C., Lovinger, D., Everitt, B. J., Egli, M., Mandyam, C. D., Fein, G., Potenza, M. N., Harris, R. A., Grant, K. K., Roberto, M. & 2 others, Meyerhoff, D. J. & Sullivan, E. V., Aug 1 2015, In : Alcohol. 49, 5, p. 435-452 18 p.

Research output: Contribution to journalArticle

Alcoholism
Brain
brain
alcohol
Alcohols
14 Citations (Scopus)

Effects of chronic alcohol consumption on neuronal function in the non-human primate BNST

Pleil, K. E., Helms, C., Sobus, J. R., Daunais, J. B., Grant, K. K. & Kash, T. L., 2015, (Accepted/In press) In : Addiction Biology.

Research output: Contribution to journalArticle

Septal Nuclei
Alcohol Drinking
Primates
Excitatory Postsynaptic Potentials
Hormones
21 Citations (Scopus)

MAOA expression predicts vulnerability for alcohol use

Cervera-Juanes, R., Wilhem, L. J., Park, B., Lee, R., Locke, J., Helms, C., Gonzales, S., Wand, G., Jones, S. R., Grant, K. K. & Ferguson, B., Jul 7 2015, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Monoamine Oxidase
Alcohols
Macaca mulatta
Dopamine
Nucleus Accumbens
3 Citations (Scopus)

Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans

Shorey-Kendrick, L. E., Ford, M., Allen, D. C., Kuryatov, A., Lindstrom, J., Wilhelm, L., Grant, K. K. & Spindel, E., Jun 27 2015, In : Neuropharmacology. 96, PB, p. 263-273 11 p., 5737.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Primates
Macaca fascicularis
Macaca
85 Citations (Scopus)

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Pleil, K. E., Rinker, J. A., Lowery-Gionta, E. G., Mazzone, C. M., McCall, N. M., Kendra, A. M., Olson, D. P., Lowell, B. B., Grant, K. K., Thiele, T. E. & Kash, T. L., Apr 28 2015, In : Nature Neuroscience. 18, 4, p. 545-552 8 p.

Research output: Contribution to journalArticle

Binge Drinking
Neuropeptide Y
Corticotropin-Releasing Hormone
Amygdala
Alcohol Drinking
8 Citations (Scopus)

Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling

Gaddini, G. W., Grant, K. K., Woodall, A., Stull, C., Maddalozzo, G. F., Zhang, B., Turner, R. T. & Iwaniec, U. T., Feb 1 2015, In : Bone. 71, p. 227-236 10 p.

Research output: Contribution to journalArticle

Bone Remodeling
Macaca mulatta
Alcohol Drinking
Alcohols
Bone Density