Kari Buck

Professor

  • 4711 Citations
  • 35 h-Index
1989 …2021
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Research Output 1989 2018

  • 4711 Citations
  • 35 h-Index
  • 92 Article
  • 3 Chapter
  • 1 Editorial
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Article
Article
16 Citations (Scopus)

5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice

Reilly, M. T., Milner, L. C., Shirley, R. L., Crabbe, J. J. & Buck, K., Mar 10 2008, In : Brain Research. 1198, p. 124-131 8 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2C
Chromosomes, Human, Pair 4
Seizures
Central Nervous System
Genes
45 Citations (Scopus)

A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models

Ehlers, C. L., Walter, N. A. R., Dick, D. M., Buck, K. & Crabbe, J. J., Apr 2010, In : Addiction Biology. 15, 2, p. 185-199 15 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Alcohols
Phenotype
Human Chromosomes
Genes
29 Citations (Scopus)
Inbred Strains Mice
Basal Ganglia
Ethanol
Alcohols
Genes
10 Citations (Scopus)

Acute Ethanol Withdrawal Impairs Contextual Learning and Enhances Cued Learning

Tipps, M. E., Raybuck, J. D., Buck, K. & Lattal, K. M., Feb 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 2, p. 282-290 9 p.

Research output: Contribution to journalArticle

Ethanol
Alcohols
Learning
Fear
Alcoholic Intoxication
22 Citations (Scopus)
GABA-A Receptors
Genes
Polymerase Chain Reaction
Messenger RNA
Chemical analysis
24 Citations (Scopus)

Alcohol actions on GABAA receptors: From protein structure to mouse behavior

Ueno, S., Harris, R. A., Messing, R. O., Sanchez-Perez, A. M., Hodge, C. W., McMahon, T., Wang, D., Mehmert, K. K., Kelley, S. P., Haywood, A., Olive, M. F., Buck, K., Hood, H. M., Blednov, Y., Findlay, G. & Mascia, M. P., 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL.

Research output: Contribution to journalArticle

GABA-A Receptors
Alcohols
Proteins
Aminobutyrates
Glycine Receptors
34 Citations (Scopus)
Hypothermia
GABA-A Receptors
Ataxia
Genetic Predisposition to Disease
Ethanol
4 Citations (Scopus)

A spontaneous deletion of α-Synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption

López-Jiménez, A., Walter, N. A. R., Giné, E., Santos, Á., Echeverry-Alzate, V., Bühler, K. M., Olmos, P., Giezendanner, S., Moratalla, R., Montoliu, L., Buck, K. & López-Moreno, J. A., Jun 2013, In : Synapse. 67, 6, p. 280-289 10 p.

Research output: Contribution to journalArticle

Synucleins
Cannabinoid Receptor CB1
Amygdala
Alcohol Drinking
Hippocampus
67 Citations (Scopus)

A strategy for the integration of QTL, gene expression, and sequence analyses

Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., Buck, K., Rademacher, B., Walter, N., Polyakov, Y., Sikela, J., Gensler, B., Burgers, S., Williams, R. W., Manly, K., Flint, J. & Talbot, C., Nov 2003, In : Mammalian Genome. 14, 11, p. 733-747 15 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Sequence Analysis
Gene Expression
Nucleotides
Genes
2 Citations (Scopus)

A systems approach implicates a brain mitochondrial oxidative homeostasis co-expression network in genetic vulnerability to alcohol withdrawal

Walter, N. A. R., Denmark, D. A. L., Kozell, L. B. & Buck, K., Jan 3 2017, In : Frontiers in Genetics. 7, JAN, 218.

Research output: Contribution to journalArticle

Systems Analysis
Homeostasis
Alcohols
Brain
Alcoholism
37 Citations (Scopus)
Chloride Channels
GABA-A Receptors
Benzodiazepines
Ethanol
Muscimol
139 Citations (Scopus)
Chloride Channels
GABA-A Receptors
Benzodiazepines
Ethanol
Muscimol
188 Citations (Scopus)
1-Methyl-4-phenylpyridinium
Norepinephrine Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Catecholamines
Dopamine
100 Citations (Scopus)
Brain
Seizures
Ethanol
Messenger RNA
GABA-A Receptors
8 Citations (Scopus)

Computational detection of alternative exon usage

Laderas, T. G., Walter, N. A. R., Mooney, M., Vartanian, K., Darakjian, P., Buck, K., Harrington, C. C., Belknap, J., Hitzemann, R. & McWeeney, S., 2011, In : Frontiers in Neuroscience. MAY, Article 69.

Research output: Contribution to journalArticle

Exons
Statistical Models
Molecular Sequence Annotation
Workflow
Genetic Models
98 Citations (Scopus)

Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a

Fehr, C., Shirley, R. L., Belknap, J., Crabbe, J. J. & Buck, K., May 1 2002, In : Journal of Neuroscience. 22, 9, p. 3730-3738 9 p.

Research output: Contribution to journalArticle

Pentobarbital
Alcohols
Chromosomes, Human, Pair 4
Alcoholism
Seizures
15 Citations (Scopus)

Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: Issues of measurement and performance

Tipps, M. E., Raybuck, J. D., Buck, K. & Lattal, K. M., 2014, In : Learning and Memory. 21, 8, p. 380-393 14 p.

Research output: Contribution to journalArticle

Inbred DBA Mouse
Fear
Learning
Conditioning (Psychology)
Molecular Biology
27 Citations (Scopus)

Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice

Chen, G., Reilly, M. T., Kozell, L. B., Hitzemann, R. & Buck, K., Sep 2009, In : Alcohol. 43, 6, p. 411-420 10 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
withdrawal
activation
Ethanol
Chemical activation
7 Citations (Scopus)

Discovering genes involved in alcohol dependence and other alcohol responses: Role of animal models

Buck, K., Milner, L. C., Denmark, D. L., Grant, S. G. N. & Kozell, L. B., 2011, In : Alcohol Research and Health. 34, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Alcoholism
Animal Models
Alcohols
Quantitative Trait Loci
Genes
3 Citations (Scopus)

Discrete structural domains and cell-specific expression determine functional selectivity of the dopamine and norepinephrine transporters.

Buck, K., Lorang, D. & Amara, S. G., 1996, In : NIDA research monograph. 161, p. 154-175 22 p.

Research output: Contribution to journalArticle

Norepinephrine Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Mood Disorders
Antidepressive Agents
Catecholamines

Distinct roles for two chromosome 1 loci in ethanol withdrawal, consumption, and conditioned place preference

Kozell, L. B., Denmark, D. L., Nicole, N. A. & Buck, K., Aug 27 2018, In : Frontiers in Genetics. 9, AUG, 323.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Quantitative Trait Loci
Ethanol
Alcohols
Reward
17 Citations (Scopus)

Dual-Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects

Metten, P., Iancu, O., Spence, S. E., Walter, N. A. R., Oberbeck, D., Harrington, C. C., Colville, A., McWeeney, S., Phillips, T., Buck, K., Crabbe, J. J., Belknap, J. & Hitzemann, R., Dec 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 12, p. 2915-2924 10 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Quantitative Trait Loci
Chromosomes
Ethanol
Genes
Gene expression
Alcohols
29 Citations (Scopus)

Ethanol-sensitive sites on the human dopamine transporter

Maiya, R., Buck, K., Adron Harris, R. & Dayne Mayfield, R., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 30724-30729 6 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Ethanol
Norepinephrine Plasma Membrane Transport Proteins
Xenopus
Oocytes
121 Citations (Scopus)

Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays

Bottomly, D., Walter, N. A. R., Hunter, J. E., Darakjian, P., Kawane, S., Buck, K., Searles, R., Mooney, M., McWeeney, S. & Hitzemann, R., 2011, In : PLoS One. 6, 3, e17820.

Research output: Contribution to journalArticle

Inbred DBA Mouse
Microarrays
Gene expression
RNA
Gene Expression
14 Citations (Scopus)
Glutamate Decarboxylase
Ethanol
Genes
Chromosomes, Human, Pair 2
Quantitative Trait Loci
59 Citations (Scopus)

Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice

Daniels, G. M. & Buck, K., Jan 2002, In : Genes, Brain and Behavior. 1, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

Ethanol
Inbred C57BL Mouse
Inbred DBA Mouse
Genes
Mitogen-Activated Protein Kinases
13 Citations (Scopus)

Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11

Hood, H. M., Metten, P., Crabbe, J. J. & Buck, K., Feb 2006, In : Genes, Brain and Behavior. 5, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 11
GABA-A Receptors
Hypnotics and Sedatives
Pharmaceutical Preparations
Genes
18 Citations (Scopus)

Fluidization of brain membranes by A2C does not produce anesthesia and does not augment muscimol-stimulated 36Cl- influx

Buck, K., Allan, A. M. & Adron Harris, R., Feb 7 1989, In : European Journal of Pharmacology. 160, 3, p. 359-367 9 p.

Research output: Contribution to journalArticle

Muscimol
Benzyl Alcohol
Anesthesia
Anesthetics
Membranes
13 Citations (Scopus)

GABA(A) receptor β2 subunit mRNA content is differentially regulated in ethanol-dependent DBA/2J and C57BL/6J mice

Reilly, M. T. & Buck, K., Nov 1 2000, In : Neurochemistry International. 37, 5-6, p. 443-452 10 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Inbred C57BL Mouse
Ethanol
Messenger RNA
Cerebellum
19 Citations (Scopus)

GABAA receptor function and regional analysis of subunit mRNAs in long-sleep and short-sleep mouse brain

Zahniser, N. R., Buck, K., Curella, P., McQuilkin, S. J., Wilson-Shaw, D., Miller, C. L., Klein, R. L., Heidenreich, K. A., Keir, W. J., Sikela, J. M. & Harris, R. A., 1992, In : Molecular Brain Research. 14, 3, p. 196-206 11 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Sleep
Messenger RNA
Brain
Ethanol
91 Citations (Scopus)

Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption

Phillips, T., Belknap, J., Buck, K. & Cunningham, C., 1998, In : Mammalian Genome. 9, 12, p. 936-941 6 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 2
Ethanol
Genes
Quantitative Trait Loci
361 Citations (Scopus)

Genetic animal models of alcohol and drug abuse

Crabbe, J. J., Belknap, J. & Buck, K., Jun 17 1994, In : Science. 264, 5166, p. 1715-1723 9 p.

Research output: Contribution to journalArticle

Genetic Models
Alcoholism
Substance-Related Disorders
Animal Models
Quantitative Trait Loci
42 Citations (Scopus)

Genetic association of a GABA(A) receptor γ2 subunit variant with severity of acute physiological dependence on alcohol

Buck, K. & Hood, H. M., 1998, In : Mammalian Genome. 9, 12, p. 975-978 4 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Alcoholism
Quantitative Trait Loci
Alcohols
Genes
47 Citations (Scopus)
Chromosome Mapping
Quantitative Trait Loci
Alcohols
Genes
Pentobarbital
9 Citations (Scopus)

Genetic variability of respiratory complex abundance, organization and activity in mouse brain

Buck, K., Walter, N. A. R. & Denmark, D. L., Feb 2014, In : Genes, Brain and Behavior. 13, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

Electrons
Native Polyacrylamide Gel Electrophoresis
Mitochondrial Diseases
Electron Transport Complex III
Brain
26 Citations (Scopus)

Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice

Hood, H. M., Belknap, J., Crabbe, J. J. & Buck, K., 2001, In : Behavior Genetics. 31, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

epistasis
pentobarbital
Pentobarbital
seizures
modifiers (genes)
9 Citations (Scopus)

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward

Tipps, M. E., Raybuck, J. D., Kozell, L. B., Lattal, K. M. & Buck, K., 2016, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
Reward
GTP-Binding Proteins
Knockout Mice
G Protein-Coupled Inwardly-Rectifying Potassium Channels
63 Citations (Scopus)

Harnessing the mouse to unravel the genetics of human disease

Phillips, T., Belknap, J., Hitzemann, R., Buck, K., Cunningham, C. & Crabbe, J. J., Jan 2002, In : Genes, Brain and Behavior. 1, 1, p. 14-26 13 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Genes
Quantitative Trait Loci
Viral Genes
Mutagenesis
106 Citations (Scopus)

"Higher order" addiction molecular genetics: Convergent data from genome-wide association in humans and mice

Uhl, G. R., Drgon, T., Johnson, C., Fatusin, O. O., Liu, Q. R., Contoreggi, C., Li, C. Y., Buck, K. & Crabbe, J. J., Jan 1 2008, In : Biochemical Pharmacology. 75, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

Methamphetamine
Molecular Biology
Genes
Alcohols
Genome
21 Citations (Scopus)

High throughput sequencing in mice: A platform comparison identifies a preponderance of cryptic SNPs

Walter, N. A. R., Bottomly, D., Laderas, T., Mooney, M., Darakjian, P., Searles, R., Harrington, C. C., McWeeney, S., Hitzemann, R. & Buck, K., Aug 17 2009, In : BMC Genomics. 10, p. 379 1 p., 1471.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genetic Models
Inbred Strains Mice
Gene Expression
Chromosomes, Human, Pair 1
212 Citations (Scopus)

Identifying genes for alcohol and drug sensitivity: Recent progress and future directions

Crabbe, J. J., Phillips, T., Buck, K., Cunningham, C. & Belknap, J., Apr 1 1999, In : Trends in Neurosciences. 22, 4, p. 173-179 7 p.

Research output: Contribution to journalArticle

Alcohols
Quantitative Trait Loci
Pharmaceutical Preparations
Genes
Direction compound
21 Citations (Scopus)

Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice

Milner, L. C. & Buck, K., 2010, In : International Review of Neurobiology. 91, C, p. 173-204 32 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Alcohols
Phenotype
Alcoholism
Genes
15 Citations (Scopus)

In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases.

Marshall, K. E., Godden, E. L., Yang, F., Burgers, S., Buck, K. & Sikela, J. M., 2002, In : Genome Biology. 3, 12

Research output: Contribution to journalArticle

Quantitative Trait Loci
Genetic Association Studies
Computer Simulation
quantitative trait loci
genome
1 Citation (Scopus)
Medical Genetics
Computational Biology
Internet
Genes
Inborn Genetic Diseases
1 Citation (Scopus)

Interval-specific congenic animals for high-resolution quantitative trait loci mapping

Denmark, D. L., Milner, L. C. & Buck, K., 2008, In : Alcohol Research and Health. 31, 3, p. 266-269 4 p.

Research output: Contribution to journalArticle

Congenic Animals
Alcohol-Related Disorders
Chromosome Mapping
Quantitative Trait Loci
Animal Models
1 Citation (Scopus)

Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice

Boudreau, E., Chen, G., Li, X., Buck, K., Hitzemann, R. & Hickman, D., Jan 2010, In : Lab Animal. 39, 1, p. 23-25 3 p.

Research output: Contribution to journalArticle

catheters
Rodentia
Catheters
image analysis
Pharmacology
1 Citation (Scopus)

In vivo generation of chimeras

Buck, K. & Amara, S. G., 1998, In : Methods. 296, p. 466-475 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus

Chen, G., Kozell, L. B., Hitzemann, R. & Buck, K., Sep 24 2008, In : Journal of Neuroscience. 28, 39, p. 9840-9849 10 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 4
Basal Ganglia
Quantitative Trait Loci
Ethanol
Alcoholism
3 Citations (Scopus)

Limbic circuitry activation in ethanol withdrawal is regulated by a chromosome 1 locus

Buck, K., Chen, G. & Kozell, L. B., Feb 1 2017, In : Alcohol. 58, p. 153-160 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Chromosomes
withdrawal
activation
Alcoholism