Kari Buck

Professor

  • 4705 Citations
  • 35 h-Index
1989 …2021
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Research Output 1989 2018

  • 4705 Citations
  • 35 h-Index
  • 92 Article
  • 3 Chapter
  • 1 Editorial
2018

Distinct roles for two chromosome 1 loci in ethanol withdrawal, consumption, and conditioned place preference

Kozell, L. B., Denmark, D. L., Nicole, N. A. & Buck, K., Aug 27 2018, In : Frontiers in Genetics. 9, AUG, 323.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Quantitative Trait Loci
Ethanol
Alcohols
Reward
2017
2 Citations (Scopus)

A systems approach implicates a brain mitochondrial oxidative homeostasis co-expression network in genetic vulnerability to alcohol withdrawal

Walter, N. A. R., Denmark, D. A. L., Kozell, L. B. & Buck, K., Jan 3 2017, In : Frontiers in Genetics. 7, JAN, 218.

Research output: Contribution to journalArticle

Systems Analysis
Homeostasis
Alcohols
Brain
Alcoholism
3 Citations (Scopus)

Limbic circuitry activation in ethanol withdrawal is regulated by a chromosome 1 locus

Buck, K., Chen, G. & Kozell, L. B., Feb 1 2017, In : Alcohol. 58, p. 153-160 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Chromosomes
withdrawal
activation
Alcoholism
2016
9 Citations (Scopus)

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward

Tipps, M. E., Raybuck, J. D., Kozell, L. B., Lattal, K. M. & Buck, K., 2016, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
Reward
GTP-Binding Proteins
Knockout Mice
G Protein-Coupled Inwardly-Rectifying Potassium Channels
8 Citations (Scopus)

The multiple PDZ domain protein Mpdz/MUPP1 regulates opioid tolerance and opioid-induced hyperalgesia

Donaldson, R., Sun, Y., Liang, D. Y., Zheng, M., Sahbaie, P., Dill, D. L., Peltz, G., Buck, K. & Clark, J. D., Apr 29 2016, In : BMC Genomics. 17, 1, 313.

Research output: Contribution to journalArticle

PDZ Domains
Hyperalgesia
Opioid Analgesics
Proteins
Morphine

The Substantia Nigra Pars Reticulata in Sedative-Hypnotic Withdrawal

Kruse, L. C. & Buck, K., May 13 2016, General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions. Elsevier Inc., Vol. 3. p. 345-355 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypnotics and Sedatives
Substance Withdrawal Syndrome
Barbiturates
Biological Factors
Benzodiazepines
2015
10 Citations (Scopus)

Acute Ethanol Withdrawal Impairs Contextual Learning and Enhances Cued Learning

Tipps, M. E., Raybuck, J. D., Buck, K. & Lattal, K. M., Feb 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 2, p. 282-290 9 p.

Research output: Contribution to journalArticle

Ethanol
Alcohols
Learning
Fear
Alcoholic Intoxication
4 Citations (Scopus)

GIRK Channels: A Potential Link Between Learning and Addiction

Tipps, M. E. & Buck, K., 2015, International Review of Neurobiology. Academic Press Inc., Vol. 123. p. 239-277 39 p. (International Review of Neurobiology; vol. 123).

Research output: Chapter in Book/Report/Conference proceedingChapter

G Protein-Coupled Inwardly-Rectifying Potassium Channels
Learning
Street Drugs
Pharmaceutical Preparations
Addictive Behavior
14 Citations (Scopus)

Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption

Milner, L. C., Shirley, R. L., Kozell, L. B., Walter, N. A., Kruse, L. C., Komiyama, N. H., Grant, S. G. N. & Buck, K., Jan 1 2015, In : Addiction Biology. 20, 1, p. 143-147 5 p.

Research output: Contribution to journalArticle

Ethanol
PDZ Domains
Genetic Models
Heterozygote
Alcoholism
2014
15 Citations (Scopus)

Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: Issues of measurement and performance

Tipps, M. E., Raybuck, J. D., Buck, K. & Lattal, K. M., 2014, In : Learning and Memory. 21, 8, p. 380-393 14 p.

Research output: Contribution to journalArticle

Inbred DBA Mouse
Fear
Learning
Conditioning (Psychology)
Molecular Biology
17 Citations (Scopus)

Dual-Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects

Metten, P., Iancu, O., Spence, S. E., Walter, N. A. R., Oberbeck, D., Harrington, C. C., Colville, A., McWeeney, S., Phillips, T., Buck, K., Crabbe, J. J., Belknap, J. & Hitzemann, R., Dec 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 12, p. 2915-2924 10 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Quantitative Trait Loci
Chromosomes
Ethanol
Genes
9 Citations (Scopus)

Genetic variability of respiratory complex abundance, organization and activity in mouse brain

Buck, K., Walter, N. A. R. & Denmark, D. L., Feb 2014, In : Genes, Brain and Behavior. 13, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

Electrons
Native Polyacrylamide Gel Electrophoresis
Mitochondrial Diseases
Electron Transport Complex III
Brain
10 Citations (Scopus)

Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal

Kruse, L. C., Walter, N. A. R. & Buck, K., Nov 1 2014, In : Genes, Brain and Behavior. 13, 8, p. 769-776 8 p.

Research output: Contribution to journalArticle

Alcohols
Small Interfering RNA
Seizures
RNA Interference
Genes
7 Citations (Scopus)
Gene Expression
2013
4 Citations (Scopus)

A spontaneous deletion of α-Synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption

López-Jiménez, A., Walter, N. A. R., Giné, E., Santos, Á., Echeverry-Alzate, V., Bühler, K. M., Olmos, P., Giezendanner, S., Moratalla, R., Montoliu, L., Buck, K. & López-Moreno, J. A., Jun 2013, In : Synapse. 67, 6, p. 280-289 10 p.

Research output: Contribution to journalArticle

Synucleins
Cannabinoid Receptor CB1
Amygdala
Alcohol Drinking
Hippocampus
2012
4 Citations (Scopus)

Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models

Buck, K., Milner, L. C., Denmark, D. L., Grant, S. G. N. & Kozell, L. B., 2012, In : Alcohol research : current reviews. 34, 3, p. 367-374 8 p.

Research output: Contribution to journalEditorial

Alcoholism
Animal Models
Alcohols
Quantitative Trait Loci
Genes
2011
8 Citations (Scopus)

Computational detection of alternative exon usage

Laderas, T. G., Walter, N. A. R., Mooney, M., Vartanian, K., Darakjian, P., Buck, K., Harrington, C. C., Belknap, J., Hitzemann, R. & McWeeney, S., 2011, In : Frontiers in Neuroscience. MAY, Article 69.

Research output: Contribution to journalArticle

Exons
Statistical Models
Molecular Sequence Annotation
Workflow
Genetic Models
7 Citations (Scopus)

Discovering genes involved in alcohol dependence and other alcohol responses: Role of animal models

Buck, K., Milner, L. C., Denmark, D. L., Grant, S. G. N. & Kozell, L. B., 2011, In : Alcohol Research and Health. 34, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Alcoholism
Animal Models
Alcohols
Quantitative Trait Loci
Genes
119 Citations (Scopus)

Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays

Bottomly, D., Walter, N. A. R., Hunter, J. E., Darakjian, P., Kawane, S., Buck, K., Searles, R., Mooney, M., McWeeney, S. & Hitzemann, R., 2011, In : PLoS One. 6, 3, e17820.

Research output: Contribution to journalArticle

Inbred DBA Mouse
Microarrays
Gene expression
RNA
Gene Expression
48 Citations (Scopus)

Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models

Chen, G., Cuzon Carlson, V., Wang, J., Beck, A., Heinz, A., Ron, D., Lovinger, D. M. & Buck, K., Oct 2011, In : Alcoholism: Clinical and Experimental Research. 35, 10, p. 1739-1748 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Alcohol Drinking
Alcoholism
Animals
Animal Models
5 Citations (Scopus)

Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice

Chen, G., Kozell, L. B. & Buck, K., Mar 17 2011, In : Behavioural Brain Research. 218, 1, p. 152-157 6 p.

Research output: Contribution to journalArticle

Hypnotics and Sedatives
Ethanol
Central Nervous System Depressants
Ibotenic Acid
Pentylenetetrazole
2010
45 Citations (Scopus)

A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models

Ehlers, C. L., Walter, N. A. R., Dick, D. M., Buck, K. & Crabbe, J. J., Apr 2010, In : Addiction Biology. 15, 2, p. 185-199 15 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Alcohols
Phenotype
Human Chromosomes
Genes
21 Citations (Scopus)

Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice

Milner, L. C. & Buck, K., 2010, In : International Review of Neurobiology. 91, C, p. 173-204 32 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Alcohols
Phenotype
Alcoholism
Genes
1 Citation (Scopus)

Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice

Boudreau, E., Chen, G., Li, X., Buck, K., Hitzemann, R. & Hickman, D., Jan 2010, In : Lab Animal. 39, 1, p. 23-25 3 p.

Research output: Contribution to journalArticle

catheters
Rodentia
Catheters
image analysis
Pharmacology
10 Citations (Scopus)

Rostroventral caudate putamen involvement in ethanol withdrawal is influenced by a chromosome 4 locus

Chen, G. & Buck, K., Oct 2010, In : Genes, Brain and Behavior. 9, 7, p. 768-776 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 4
Putamen
Ethanol
Alcohols
Alcoholism
2009
27 Citations (Scopus)

Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice

Chen, G., Reilly, M. T., Kozell, L. B., Hitzemann, R. & Buck, K., Sep 2009, In : Alcohol. 43, 6, p. 411-420 10 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
withdrawal
activation
Ethanol
Chemical activation
21 Citations (Scopus)

High throughput sequencing in mice: A platform comparison identifies a preponderance of cryptic SNPs

Walter, N. A. R., Bottomly, D., Laderas, T., Mooney, M., Darakjian, P., Searles, R., Harrington, C. C., McWeeney, S., Hitzemann, R. & Buck, K., Aug 17 2009, In : BMC Genomics. 10, p. 379 1 p., 1471.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genetic Models
Inbred Strains Mice
Gene Expression
Chromosomes, Human, Pair 1
40 Citations (Scopus)

Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol

Kozell, L. B., Walter, N. A. R., Milner, L. C., Wickman, K. & Buck, K., Sep 16 2009, In : Journal of Neuroscience. 29, 37, p. 11662-11673 12 p.

Research output: Contribution to journalArticle

Pentobarbital
Hypnotics and Sedatives
Ethanol
Quantitative Trait Loci
Genes
2008
16 Citations (Scopus)

5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice

Reilly, M. T., Milner, L. C., Shirley, R. L., Crabbe, J. J. & Buck, K., Mar 10 2008, In : Brain Research. 1198, p. 124-131 8 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2C
Chromosomes, Human, Pair 4
Seizures
Central Nervous System
Genes
105 Citations (Scopus)

"Higher order" addiction molecular genetics: Convergent data from genome-wide association in humans and mice

Uhl, G. R., Drgon, T., Johnson, C., Fatusin, O. O., Liu, Q. R., Contoreggi, C., Li, C. Y., Buck, K. & Crabbe, J. J., Jan 1 2008, In : Biochemical Pharmacology. 75, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

Methamphetamine
Molecular Biology
Genes
Alcohols
Genome
1 Citation (Scopus)

Interval-specific congenic animals for high-resolution quantitative trait loci mapping

Denmark, D. L., Milner, L. C. & Buck, K., 2008, In : Alcohol Research and Health. 31, 3, p. 266-269 4 p.

Research output: Contribution to journalArticle

Congenic Animals
Alcohol-Related Disorders
Chromosome Mapping
Quantitative Trait Loci
Animal Models
15 Citations (Scopus)

Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus

Chen, G., Kozell, L. B., Hitzemann, R. & Buck, K., Sep 24 2008, In : Journal of Neuroscience. 28, 39, p. 9840-9849 10 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 4
Basal Ganglia
Quantitative Trait Loci
Ethanol
Alcoholism
11 Citations (Scopus)

Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3

Kozell, L., Belknap, J., Hofstetter, J. R., Mayeda, A. & Buck, K., Jul 2008, In : Genes, Brain and Behavior. 7, 5, p. 560-567 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Quantitative Trait Loci
Human Chromosomes
Alcoholism
Alcohols
14 Citations (Scopus)
Chromosomes, Human, Pair 1
Genetic Association Studies
Alcoholism
Quantitative Trait Loci
Ethanol

Single-nucleotide polymorphism masking

Walter, N. A. R., McWeeney, S., Peters, S. T., Belknap, J., Hitzemann, R. & Buck, K., 2008, In : Alcohol Research and Health. 31, 3, p. 270-271 2 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Gene Expression Profiling
Microarray Analysis
Oligonucleotide Array Sequence Analysis
Single Nucleotide Polymorphism
2007
53 Citations (Scopus)

SNPs matter: Impact on detection of differential expression [3]

Walter, N. A. R., McWeeney, S., Peters, S. T., Belknap, J., Hitzemann, R. & Buck, K., Sep 2007, In : Nature Methods. 4, 9, p. 679-680 2 p.

Research output: Contribution to journalArticle

Gene expression
Animals
Genes
8 Citations (Scopus)

Use of a novel mouse genotype to model acute benzodiazepine withdrawal

Metten, P., Buck, K., Merrill, C. M., Roberts, A. J., Yu, C. H. & Crabbe, J. J., Jan 2007, In : Behavior Genetics. 37, 1, p. 160-170 11 p.

Research output: Contribution to journalArticle

benzodiazepines
GABA-A Receptors
Benzodiazepines
Seizures
drug
2006
13 Citations (Scopus)

Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11

Hood, H. M., Metten, P., Crabbe, J. J. & Buck, K., Feb 2006, In : Genes, Brain and Behavior. 5, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 11
GABA-A Receptors
Hypnotics and Sedatives
Pharmaceutical Preparations
Genes
2005
29 Citations (Scopus)
Inbred Strains Mice
Basal Ganglia
Ethanol
Alcohols
Genes
40 Citations (Scopus)

The syntaxin binding protein 1 gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2

Fehr, C., Shirley, R. L., Crabbe, J. J., Belknap, J., Buck, K. & Phillips, T., May 2005, In : Alcoholism: Clinical and Experimental Research. 29, 5, p. 708-720 13 p.

Research output: Contribution to journalArticle

Qa-SNARE Proteins
Chromosomes, Human, Pair 2
Chromosomes
Drinking
Carrier Proteins
2004
Gene expression
Alcohols
108 Citations (Scopus)

Mpdz is a quantitative trait gene for drug withdrawal seizures

Shirley, R. L., Walter, N. A. R., Reilly, M. T., Fehr, C. & Buck, K., Jul 2004, In : Nature Neuroscience. 7, 7, p. 699-700 2 p.

Research output: Contribution to journalArticle

Substance-Related Disorders
Seizures
Pharmaceutical Preparations
Genes
PDZ Domains
46 Citations (Scopus)

On the integration of alcohol-related quantitative trait loci and gene expression analyses

Hitzemann, R., Reed, C., Malmanger, B., Lawler, M., Hitzemann, B., Cunningham, B., McWeeney, S., Belknap, J., Harrington, C. C., Buck, K., Phillips, T. & Crabbe, J. J., Oct 2004, In : Alcoholism: Clinical and Experimental Research. 28, 10, p. 1437-1448 12 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Gene expression
Ethanol
Alcohols
Gene Expression
16 Citations (Scopus)

Potential pleiotropic effects of Mpdz on vulnerability to seizures

Fehr, C., Shirley, R. L., Metten, P., Kosobud, A. E. K., Belknap, J., Crabbet, J. C. & Buck, K., Feb 2004, In : Genes, Brain and Behavior. 3, 1, p. 8-19 12 p.

Research output: Contribution to journalArticle

Pentobarbital
Seizures
Alcohols
Quantitative Trait Loci
Central Nervous System Depressants
19 Citations (Scopus)

Selection for pentobarbital withdrawal severity: Correlated differences in withdrawal from other sedative drugs

Kliethermes, C. L., Metten, P., Belknap, J., Buck, K. & Crabbe, J. J., May 29 2004, In : Brain Research. 1009, 1-2, p. 17-25 9 p.

Research output: Contribution to journalArticle

Pentobarbital
Hypnotics and Sedatives
Pharmaceutical Preparations
Seizures
Diazepam
7 Citations (Scopus)

Serotonin 5-HT2 Receptors and Alcohol: Reward, Withdrawal and Discrimination

Buck, K., Reilly, M. T., Rogers, L. M., Szeliga, K., Grant, K. K. & Brodie, M. S., Feb 2004, In : Alcoholism: Clinical and Experimental Research. 28, 2, p. 211-216 6 p.

Research output: Contribution to journalArticle

Serotonin 5-HT2 Receptors
Reward
Ethanol
Alcohols
PDZ Domains
636 Citations (Scopus)

The Collaborative Cross, a community resource for the genetic analysis of complex traits

Churchill, G. A., Airey, D. C., Allayee, H., Angel, J. M., Attie, A. D., Beatty, J., Beavis, W. D., Belknap, J., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, K. W., Buck, K., Buckler, E., Burmeister, M., Chesler, E. J., Cheverud, J. M., Clapcote, S., Cook, M. N. & 93 others, Cox, R. D., Crabbe, J. J., Crusio, W. E., Darvasi, A., Deschepper, C. F., Doerge, R. W., Farber, C. R., Forejt, J., Gaile, D., Garlow, S. J., Geiger, H., Gershenfeld, H., Gordon, T., Gu, J., Gu, W., de Haan, G., Hayes, N. L., Heller, C., Himmelbauer, H., Hitzemann, R., Hunter, K., Hsu, H. C., Iraqi, F. A., Ivandic, B., Jacob, H. J., Jansen, R. C., Jepsen, K. J., Johnson, D. K., Johnson, T. E., Kempermann, G., Kendziorski, C., Kotb, M., Kooy, R. F., Llamas, B., Lammert, F., Lassalle, J. M., Lowenstein, P. R., Lu, L., Lusis, A., Manly, K. F., Marcucio, R., Matthews, D., Medrano, J. F., Miller, D. R., Mittleman, G., Mock, B. A., Mogil, J. S., Montagutelli, X., Morahan, G., Morris, D. G., Mott, R., Nadeau, J. H., Nagase, H., Nowakowski, R. S., O'Hara, B. F., Osadchuk, A. V., Page, G. P., Paigen, B., Paigen, K., Palmer, A. A., Pan, H. J., Peltonen-Palotie, L., Peirce, J., Pomp, D., Pravenec, M., Prows, D. R., Qi, Z., Reeves, R. H., Roder, J., Rosen, G. D., Schadt, E. E., Schalkwyk, L. C., Seltzer, Z., Shimomura, K., Shou, S., Sillanpää, M. J., Siracusa, L. D., Snoeck, H. W., Spearow, J. L., Svenson, K., Tarantino, L. M., Threadgill, D., Toth, L. A., Valdar, W., Pardo-Manuel de Villena, F., Warden, C., Whatley, S., Williams, R. W., Wiltshire, T., Yi, N., Zhang, D., Zhang, M. & Zou, F., Nov 2004, In : Nature Genetics. 36, 11, p. 1133-1137 5 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Genetic Loci
Systems Analysis
Health
2003
67 Citations (Scopus)

A strategy for the integration of QTL, gene expression, and sequence analyses

Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., Buck, K., Rademacher, B., Walter, N., Polyakov, Y., Sikela, J., Gensler, B., Burgers, S., Williams, R. W., Manly, K., Flint, J. & Talbot, C., Nov 2003, In : Mammalian Genome. 14, 11, p. 733-747 15 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Sequence Analysis
Gene Expression
Nucleotides
Genes
14 Citations (Scopus)
Glutamate Decarboxylase
Ethanol
Genes
Chromosomes, Human, Pair 2
Quantitative Trait Loci
1 Citation (Scopus)
Medical Genetics
Computational Biology
Internet
Genes
Inborn Genetic Diseases