Justin Merritt

Associate Professor

  • 1954 Citations
  • 23 h-Index
20012020
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Research Output 2001 2019

  • 1954 Citations
  • 23 h-Index
  • 65 Article
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Article
2019

An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters

Hao, T., Xie, Z., Wang, M., Liu, L., Zhang, Y., Wang, W., Zhang, Z., Zhao, X., Li, P., Guo, Z., Gao, S., Lou, C., Zhang, G., Merritt, J., Horsman, G. P. & Chen, Y., Dec 1 2019, In : Nature communications. 10, 1, 3665.

Research output: Contribution to journalArticle

Open Access
Anaerobic Bacteria
Multigene Family
Biological Products
genes
bacteria

At the Interface of Materials and Microbiology: A Call for the Development of Standardized Approaches to Assay Biomaterial-Biofilm Interactions

Kreth, J., Ferracane, J. L., Pfeifer, C. S., Khajotia, S. & Merritt, J., Jul 1 2019, In : Journal of dental research. 98, 8, p. 850-852 3 p.

Research output: Contribution to journalArticle

Materials Testing
Streptococcus mutans
Composite Resins
Biocompatible Materials
Biofilms
Streptococcus suis
Zoonoses
Pathogens
NAD
Homeostasis
1 Citation (Scopus)

Genome-wide screening of potential RNase Y-processed mRNAs in the M49 serotype Streptococcus pyogenes NZ131

Chen, Z., Raghavan, R., Qi, F., Merritt, J. & Kreth, J., Apr 1 2019, In : MicrobiologyOpen. 8, 4, e00671.

Research output: Contribution to journalArticle

Open Access
Streptococcus pyogenes
Ribonucleases
Genome
Messenger RNA
Streptococcus
2018
4 Citations (Scopus)

Distinct regulatory role of carbon catabolite protein A (CcpA) in oral streptococcal spxB expression

Redanz, S., Masilamani, R., Cullin, N., Giacaman, R. A., Merritt, J. & Kreth, J., Apr 1 2018, In : Journal of Bacteriology. 200, 8, e00619-17.

Research output: Contribution to journalArticle

Staphylococcal Protein A
Carbon
Streptococcus gordonii
Carbohydrates
Streptococcus
5 Citations (Scopus)

Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome

Redanz, S., Cheng, X., Giacaman, R. A., Pfeifer, C., Merritt, J. & Kreth, J., Jan 1 2018, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

lactate 2-monooxygenase
Microbiota
Hydrogen Peroxide
Pyruvate Oxidase
Oral Health

LytTR Regulatory Systems: A potential new class of prokaryotic sensory system

Zou, Z., Qin, H., Brenner, A. E., Raghavan, R., Millar, J. A., Gu, Q., Xie, Z., Kreth, J. & Merritt, J., Oct 1 2018, In : PLoS Genetics. 14, 10, p. e1007709

Research output: Contribution to journalArticle

sensory system
operon
Operon
protein
Streptococcus mutans
6 Citations (Scopus)

Plasticity of the pyruvate node modulates hydrogen peroxide production and acid tolerance in multiple oral streptococci

Cheng, X., Redanz, S., Cullin, N., Zhou, X., Xu, X., Joshi, V., Koley, D., Merritt, J. & Kreth, J., Jan 1 2018, In : Applied and Environmental Microbiology. 84, 2, e01697-17.

Research output: Contribution to journalArticle

acid tolerance
Streptococcus gordonii
Streptococcus
Pyruvic Acid
hydrogen peroxide
2017
1 Citation (Scopus)

Identification of new degrons in Streptococcus mutans reveals a novel strategy for engineering targeted, controllable proteolysis

Liu, N., Chaudhry, M. T., Xie, Z., Kreth, J. & Merritt, J., Dec 19 2017, In : Frontiers in Microbiology. 8, DEC, 2572.

Research output: Contribution to journalArticle

Streptococcus mutans
Proteolysis
Poisons
Proteins
Peptide Hydrolases
2 Citations (Scopus)

Interference of a speB 5′ untranslated region partial deletion with mRNA degradation in Streptococcus pyogenes

Chen, Z., Mashburn-Warren, L., Merritt, J., Federle, M. J. & Kreth, J., 2017, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

5' Untranslated Regions
Streptococcus pyogenes
RNA Stability
Messenger RNA
Ribonucleases
18 Citations (Scopus)

Mechanistic, genomic and proteomic study on the effects of BisGMA-derived biodegradation product on cariogenic bacteria

Sadeghinejad, L., Cvitkovitch, D. G., Siqueira, W. L., Merritt, J., Santerre, J. P. & Finer, Y., Feb 1 2017, In : Dental Materials. 33, 2, p. 175-190 16 p.

Research output: Contribution to journalArticle

Propane
Biodegradation
Proteomics
Bacteria
Biofilms
1 Citation (Scopus)

Murein hydrolase LytF of Streptococcus sanguinis and the ecological consequences of competence development

Cullin, N., Redanz, S., Lampi, K., Merritt, J. & Kreth, J., Dec 1 2017, In : Applied and Environmental Microbiology. 83, 24, e01709-17.

Research output: Contribution to journalArticle

Streptococcus sanguinis
N-Acetylmuramoyl-L-alanine Amidase
peptidoglycans
Biofilms
hydrolases
5 Citations (Scopus)
Veillonella
Microbiota
Mental Competency
Veillonellaceae
Aptitude
4 Citations (Scopus)

Negative regulation of ectoine uptake and catabolism in Sinorhizobium meliloti: Characterization of the EhuR gene

Yu, Q., Cai, H., Zhang, Y., He, Y., Chen, L., Merritt, J., Zhang, S. & Dong, Z., 2017, In : Journal of Bacteriology. 199, 1, e00119-16.

Research output: Contribution to journalArticle

Sinorhizobium meliloti
Operon
Genes
Surface Plasmon Resonance
ectoine
4 Citations (Scopus)
Streptococcus mutans
Nucleic Acid Repetitive Sequences
Mutagenesis
Organism Cloning
Fenclonine
2016
1 Citation (Scopus)

Effect of salivary agglutination on oral streptococcal clearance by human polymorphonuclear neutrophil granulocytes

Itzek, A., Chen, Z., Merritt, J. & Kreth, J., 2016, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

Agglutination
Phagocytosis
Granulocytes
Neutrophils
Streptococcus gordonii
9 Citations (Scopus)
bioluminescence
Biofilms
Luciferases
biofilm
mouth
6 Citations (Scopus)

Real-time assessment of Streptococcus mutans biofilm metabolism on resin composite

Esteban Florez, F. L., Hiers, R. D., Smart, K., Kreth, J., Qi, F., Merritt, J. & Khajotia, S. S., Oct 1 2016, In : Dental Materials. 32, 10, p. 1263-1269 7 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Composite Resins
Biofilms
Metabolism
Bioluminescence
20 Citations (Scopus)

The road less traveled - defining molecular commensalism with Streptococcus sanguinis

Kreth, J., Giacaman, R. A., Raghavan, R. & Merritt, J., 2016, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

Symbiosis
Oral Health
Streptococcus
Mouth Diseases
Stomatognathic Diseases
2015
14 Citations (Scopus)
Veillonella
Porphyromonas gingivalis
Cheek
Hemagglutinins
Streptococcus
1 Citation (Scopus)

RNA regulators of host immunity and pathogen adaptive responses in the oral cavity

Kreth, J., Liu, N., Chen, Z. & Merritt, J., Jul 1 2015, In : Microbes and Infection. 17, 7, p. 493-504 12 p.

Research output: Contribution to journalArticle

Adaptive Immunity
Mouth
RNA
Explosions
4 Citations (Scopus)

RNases J1 and J2 are critical pleiotropic regulators in Streptococcus mutans

Chen, X., Liu, N., Khajotia, S., Qi, F. & Merritt, J., Apr 1 2015, In : Microbiology (Reading, England). 161, p. 797-806 10 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Ribonucleases
RNA Stability
Bacillus subtilis
Bacteria
20 Citations (Scopus)

The Streptococcus mutans irvA Gene Encodes a trans-Acting Riboregulatory mRNA

Liu, N., Niu, G., Xie, Z., Chen, Z., Itzek, A., Kreth, J., Gillaspy, A., Zeng, L., Burne, R., Qi, F. & Merritt, J., Jan 8 2015, In : Molecular Cell. 57, 1, p. 179-190 12 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Messenger RNA
Genes
5' Untranslated Regions
RNA Stability
2014
8 Citations (Scopus)

Ubiquitous sialometabolism present among oral fusobacteria

Yoneda, S., Loeser, B., Feng, J., Dmytryk, J., Qi, F. & Merritt, J., Jun 4 2014, In : PLoS One. 9, 6, e99263.

Research output: Contribution to journalArticle

Fusobacteria
Fusobacterium nucleatum
sialic acids
N-Acetylneuraminic Acid
mouth
2013
9 Citations (Scopus)

Cloning-independent plasmid construction for genetic studies in streptococci

Xie, Z., Qi, F. & Merritt, J., 2013, In : Journal of Microbiological Methods. 94, 2, p. 77-82 6 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Streptococcus
Genetic Vectors
Organism Cloning
Plasmids
10 Citations (Scopus)
antitoxins
Antitoxins
Streptococcus mutans
Xylose
gene induction
2012
8 Citations (Scopus)

Establishment of a tractable genetic transformation system in Veillonella spp.

Liu, J., Xie, Z., Merritt, J. & Qi, F., May 2012, In : Applied and Environmental Microbiology. 78, 9, p. 3488-3491 4 p.

Research output: Contribution to journalArticle

Veillonella
Genetic Transformation
genetic transformation
genetic vectors
Genetic Vectors
70 Citations (Scopus)

The mutacins of Streptococcus mutans: Regulation and ecology

Merritt, J. & Qi, F., Apr 2012, In : Molecular Oral Microbiology. 27, 2, p. 57-69 13 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Ecology
Bacteriocins
Biofilms
Tooth
2011
50 Citations (Scopus)

Cloning-independent and counterselectable markerless mutagenesis system in streptococcus mutans

Xie, Z., Okinaga, T., Qi, F., Zhang, Z. & Merritt, J., Nov 2011, In : Applied and Environmental Microbiology. 77, 22, p. 8025-8033 9 p.

Research output: Contribution to journalArticle

Streptococcus mutans
mutagenesis
Mutagenesis
Organism Cloning
molecular cloning
29 Citations (Scopus)

Differential response of Streptococcus mutans towards friend and foe in mixed-species cultures

Liu, J., Wu, C., Huang, I. H., Merritt, J. & Qi, F., Sep 2011, In : Microbiology. 157, 9, p. 2433-2444 12 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Streptococcus gordonii
Down-Regulation
Growth
Veillonella
5 Citations (Scopus)

Genetic transformation of Veillonella parvula

Liu, J., Merritt, J. & Qi, F., Sep 2011, In : FEMS Microbiology Letters. 322, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

Veillonella
Genetic Transformation
Mouth
Mutation
Electroporation
27 Citations (Scopus)

Hydrogen peroxide-dependent DNA release and transfer of antibiotic resistance genes in Streptococcus gordonii

Itzek, A., Zheng, L., Chen, Z., Merritt, J. & Kreth, J., Dec 2011, In : Journal of Bacteriology. 193, 24, p. 6912-6922 11 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
Microbial Drug Resistance
Hydrogen Peroxide
DNA
Genes
2010
54 Citations (Scopus)

Community and gene composition of a human dental plaque microbiota obtained by metagenomic sequencing

Xie, G., Chain, P. S. G., Lo, C. C., Liu, K. L., Gans, J., Merritt, J. & Qi, F., Dec 2010, In : Molecular Oral Microbiology. 25, 6, p. 391-405 15 p.

Research output: Contribution to journalArticle

Metagenomics
Dental Plaque
Microbiota
Genes
Mouth Diseases
34 Citations (Scopus)

Examination of the hdrRM regulon yields insight into the competence system of Streptococcus mutans

Okinaga, T., Xie, Z., Niu, G., Qi, F. & Merritt, J., 2010, In : Molecular Oral Microbiology. 25, 3, p. 165-177 13 p.

Research output: Contribution to journalArticle

Regulon
Streptococcus mutans
Mental Competency
Bacteriocins
Genes
34 Citations (Scopus)
Peptide Synthases
Polyketide Synthases
genomic islands
polyketide synthases
Streptococcus mutans
29 Citations (Scopus)

Identification of a novel bacteriocin regulatory system in Streptococcus mutans

Xie, Z., Okinaga, T., Niu, G., Qi, F. & Merritt, J., Dec 2010, In : Molecular Microbiology. 78, 6, p. 1431-1447 17 p.

Research output: Contribution to journalArticle

Bacteriocins
Streptococcus mutans
Operon
Membrane Proteins
Nucleic Acid Repetitive Sequences
47 Citations (Scopus)

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

Joyner, P. M., Liu, J., Zhang, Z., Merritt, J., Qi, F. & Cichewicz, R. H., Dec 21 2010, In : Organic and Biomolecular Chemistry. 8, 24, p. 5486-5489 4 p.

Research output: Contribution to journalArticle

streptococcus
Streptococcus mutans
pathogens
metabolites
Mycelium
12 Citations (Scopus)

Regulation of ciaXRH operon expression and identification of the CiaR regulon in Streptococcus mutans

Wu, C., Ayala, E. A., Downey, J. S., Merritt, J., Goodman, S. D. & Qi, F., Sep 2010, In : Journal of Bacteriology. 192, 18, p. 4669-4679 11 p.

Research output: Contribution to journalArticle

Regulon
Streptococcus mutans
Operon
Phenotype
Genes
39 Citations (Scopus)

The hdrRM operon of Streptococcus mutans encodes a novel regulatory system for coordinated competence development and bacteriocin production

Okinaga, T., Niu, G., Xie, Z., Qi, F. & Merritt, J., Apr 2010, In : Journal of Bacteriology. 192, 7, p. 1844-1852 9 p.

Research output: Contribution to journalArticle

Bacteriocins
Streptococcus mutans
Operon
Mental Competency
Regulator Genes
5 Citations (Scopus)

The Streptococcus mutans IrvR repressor is a CI-like regulator that functions through autocleavage and Clp-dependent proteolysis

Niu, G., Okinaga, T., Qi, F. & Merritt, J., Mar 2010, In : Journal of Bacteriology. 192, 6, p. 1586-1595 10 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Proteolysis
Lysogeny
Amino Acids
Aptitude
2009
22 Citations (Scopus)

Autoaggregation response of Fusobacterium nucleatum

Merritt, J., Niu, G., Okinaga, T. & Qi, F., Dec 2009, In : Applied and Environmental Microbiology. 75, 24, p. 7725-7733 9 p.

Research output: Contribution to journalArticle

Fusobacterium nucleatum
inhibitor
gene
mouth
saliva
87 Citations (Scopus)

Bacterial and host interactions of oral streptococci

Kreth, J., Merritt, J. & Qi, F., Aug 1 2009, In : DNA and Cell Biology. 28, 8, p. 397-403 7 p.

Research output: Contribution to journalArticle

Biofilms
Streptococcus
Mouth Diseases
Ecology
Immune System
15 Citations (Scopus)

Genes involved in the repression of mutacin I production in Streptococcus mutans

Nguyen, T., Zhang, Z., Huang, I. H., Wu, C., Merritt, J., Shi, W. & Qi, F., Jan 1 2009, In : Microbiology. 155, 2, p. 551-556 6 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Genes
Clone Cells
Bacteriocins
Mutation
14 Citations (Scopus)

Role of the Streptococcus mutans irvA gene in GbpC-independent, dextran-dependent aggregation and biofilm formation

Zhu, M., Ajdić, D., Liu, Y., Lynch, D., Merritt, J. & Banas, J. A., Nov 2009, In : Applied and Environmental Microbiology. 75, 22, p. 7037-7043 7 p.

Research output: Contribution to journalArticle

Streptococcus mutans
dextran
Biofilms
Dextrans
biofilm
2008
20 Citations (Scopus)

Characterization of irvR, a novel regulator of the irvA-dependent pathway required for genetic competence and dextran-dependent aggregation in Streptococcus mutans

Niu, G., Okinaga, T., Zhu, L., Banas, J., Qi, F. & Merritt, J., Nov 2008, In : Journal of Bacteriology. 190, 21, p. 7268-7274 7 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Dextrans
Mental Competency
Mutation
Genetic Vectors
62 Citations (Scopus)

Immunological evaluation of Lactobacillus casei Zhang: A newly isolated strain from koumiss in Inner Mongolia, China

Ya, T., Zhang, Q., Chu, F., Merritt, J., Bilige, M., Sun, T., Du, R. & Zhang, H., Nov 19 2008, In : BMC Immunology. 9, 68.

Research output: Contribution to journalArticle

Lactobacillus casei
Lactobacillus
China
Probiotics
Hot Temperature
38 Citations (Scopus)

Role of sucrose in the fitness of Streptococcus mutans

Kreth, J., Zhu, L., Merritt, J., Shi, W. & Qi, F., Jun 2008, In : Oral Microbiology and Immunology. 23, 3, p. 213-219 7 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Sucrose
Dental Caries
Biofilms
Carbohydrates
22 Citations (Scopus)

The cia operon of Streptococcus mutans encodes a unique component required for calcium-mediated autoregulation

He, X., Wu, C., Yarbrough, D., Sim, L., Niu, G., Merritt, J., Shi, W. & Qi, F., Oct 2008, In : Molecular Microbiology. 70, 1, p. 112-126 15 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Operon
Homeostasis
Calcium
Phenotype
2007
17 Citations (Scopus)

Construction of a counterselection-based in-frame deletion system for genetic studies of Streptococcus mutans

Merritt, J., Tsang, P., Zheng, L., Shi, W. & Qi, F., Apr 2007, In : Oral Microbiology and Immunology. 22, 2, p. 95-102 8 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Galactose
Plasmids
Galactosidases
Lac Operon
22 Citations (Scopus)

Genetic characterization of the hdrRM operon: A novel high-cell-density-responsive regulator in Streptococcus mutans

Merritt, J., Zheng, L., Shi, W. & Qi, F., Aug 2007, In : Microbiology. 153, 8, p. 2765-2773 9 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Operon
Cell Count
Bacteriocins
Biofilms