Joshi Alumkal

Associate Professor

  • 2517 Citations
  • 24 h-Index
20022019
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Research Output 2004 2019

2019

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Coleman, D. J., Gao, L., King, C. J., Schwartzman, J., Urrutia, J., Sehrawat, A., Tayou, J., Balter, A., Burchard, J., Chiotti, K. E., Derrick, D. S., Sun, D., Xia, Z., Heiser, L. & Alumkal, J., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Androgen Receptors
Castration
Prostatic Neoplasms
RNA Sequence Analysis
Neoplasms

Correction: Epigenetic therapy with panobinostat combined with bicalutamide rechallenge in castration-resistant prostate cancer (Clinical Cancer Research (2019) 25 (52-63) DOI: 10.1158/1078-0432.CCR-18-1589)

Ferrari, A. C., Alumkal, J., Stein, M. N., Taplin, M. E., Babb, J., Barnett, E. S., Gomez-Pinillos, A., Liu, X., Moore, D., DiPaola, R. & Beer, T. T., Apr 15 2019, In : Clinical Cancer Research. 25, 8, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Castration
Epigenomics
Prostatic Neoplasms
Emotions
Research
3 Citations (Scopus)

Epigenetic therapy with panobinostat combined with bicalutamide rechallenge in castration-resistant prostate cancer

Ferrari, A. C., Alumkal, J., Stein, M. N., Taplin, M. E., Babb, J., Barnett, E. S., Gomez-Pinillos, A., Liu, X., Moore, D., DiPaola, R. & Beer, T. T., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 52-63 12 p.

Research output: Contribution to journalArticle

Castration
Epigenomics
Prostatic Neoplasms
Arm
Androgen Receptors
4 Citations (Scopus)

Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer

Chen, W. S., Aggarwal, R., Zhang, L., Zhao, S. G., Thomas, G., Beer, T. T., Quigley, D. A., Foye, A., Playdle, D., Huang, J., Lloyd, P., Lu, E., Sun, D., Guan, X., Rettig, M., Gleave, M., Evans, C. P., Youngren, J., True, L., Lara, P. & 8 others, Kothari, V., Xia, Z., Chi, K. N., Reiter, R. E., Maher, C. A., Feng, F. Y., Small, E. J. & Alumkal, J., Jan 1 2019, In : European Urology.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Catenins
Survival Analysis
Survival
3 Citations (Scopus)

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

Coleman, D. J., Gao, L., Schwartzman, J., Korkola, J., Sampson, D., Derrick, D. S., Urrutia, J., Balter, A., Burchard, J., King, C. J., Chiotti, K. E., Heiser, L. & Alumkal, J., Dec 1 2019, In : Scientific Reports. 9, 1, 3823.

Research output: Contribution to journalArticle

Open Access
Castration
Prostatic Neoplasms
Maintenance
Androgen Receptors
Cell Line
1 Citation (Scopus)

MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer

Nickols, N. G., Nazarian, R., Zhao, S. G., Tan, V., Uzunangelov, V., Xia, Z., Baertsch, R., Neeman, E., Gao, A. C., Thomas, G., Howard, L., De Hoedt, A. M., Stuart, J., Goldstein, T., Chi, K., Gleave, M. E., Graff, J., Beer, T. T., Drake, J. M., Evans, C. P. & 11 others, Aggarwal, R., Foye, A., Feng, F. Y., Small, E. J., Aronson, W. J., Freedland, S. J., Witte, O. N., Huang, J., Alumkal, J., Reiter, R. E. & Rettig, M. B., Jan 1 2019, In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Open Access
Castration
Mitogen-Activated Protein Kinase Kinases
Prostatic Neoplasms
Therapeutics
Phosphotransferases

Multi-omics analyses detail metabolic reprogramming in lipids, carnitines, and use of glycolytic intermediates between prostate small cell neuroendocrine carcinoma and prostate adenocarcinoma

Gao, B., Lue, H. W., Podolak, J., Fan, S., Zhang, Y., Serawat, A., Alumkal, J., Fiehn, O. & Thomas, G., May 1 2019, In : Metabolites. 9, 5, 82.

Research output: Contribution to journalArticle

Open Access
Neuroendocrine Carcinoma
Small Cell Carcinoma
Carnitine
Prostate
Adenocarcinoma

Reply to a. Dalla volta et al

Aggarwal, R., Huang, J., Alumkal, J., Feng, F. Y., Zhang, L., Stuart, J. M. & Small, E. J., Feb 1 2019, In : Journal of Clinical Oncology. 37, 4, p. 351-352 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity

Aggarwal, R. R., Quigley, D. A., Huang, J., Zhang, L., Beer, T. T., Rettig, M. B., Reiter, R. E., Gleave, M. E., Thomas, G., Foye, A., Playdle, D., Lloyd, P., Chi, K. N., Evans, C. P., Lara, P. N., Feng, F. Y., Alumkal, J. & Small, E. J., Jun 1 2019, In : Molecular cancer research : MCR. 17, 6, p. 1235-1240 6 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Neuroendocrine Cells
Small Cell Carcinoma
Prostatic Neoplasms
Genome
2018
52 Citations (Scopus)

Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: A multi-institutional prospective study

Aggarwal, R., Huang, J., Alumkal, J., Zhang, L., Feng, F. Y., Thomas, G., Weinstein, A. S., Friedl, V., Zhang, C., Witte, O. N., Lloyd, P., Gleave, M., Evans, C. P., Youngren, J., Beer, T. T., Rettig, M., Wong, C. K., True, L., Foye, A., Playdle, D. & 11 others, Ryan, C. J., Lara, P., Chi, K. N., Uzunangelov, V., Sokolov, A., Newton, Y., Beltran, H., Demichelis, F., Rubin, M. A., Stuart, J. M. & Small, E. J., Aug 20 2018, In : Journal of Clinical Oncology. 36, 24, p. 2492-2503 12 p.

Research output: Contribution to journalArticle

Neuroendocrine Cells
Prostatic Neoplasms
Prospective Studies
Castration
Therapeutics
2 Citations (Scopus)

DNA repair gene alterations and PARP inhibitor response in patients with metastatic castration-resistant prostate cancer

Lu, E., Thomas, G., Chen, Y., Wyatt, A. W., Lloyd, P., Youngren, J., Quigley, D., Bergan, R., Bailey, S., Beer, T. T., Feng, F. Y., Small, E. J. & Alumkal, J., Aug 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 8, p. 933-937 5 p.

Research output: Contribution to journalArticle

Castration
DNA Repair
Prostatic Neoplasms
Genes
BRCA2 Gene
6 Citations (Scopus)

Erratum: Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer (Cell (2018) 174(3) (758–769.e9), (S0092867418308420) (10.1016/j.cell.2018.06.039))

Quigley, D. A., Dang, H. X., Zhao, S. G., Lloyd, P., Aggarwal, R., Alumkal, J., Foye, A., Kothari, V., Perry, M. D., Bailey, A. M., Playdle, D., Barnard, T. J., Zhang, L., Zhang, J., Youngren, J. F., Cieslik, M. P., Parolia, A., Beer, T. T., Thomas, G., Chi, K. N. & 43 others, Gleave, M., Lack, N. A., Zoubeidi, A., Reiter, R. E., Rettig, M. B., Witte, O., Ryan, C. J., Fong, L., Kim, W., Friedlander, T., Chou, J., Li, H., Das, R., Li, H., Moussavi-Baygi, R., Goodarzi, H., Gilbert, L. A., Lara, P. N., Evans, C. P., Goldstein, T. C., Stuart, J. M., Tomlins, S. A., Spratt, D. E., Cheetham, R. K., Cheng, D. T., Farh, K., Gehring, J. S., Hakenberg, J., Liao, A., Febbo, P. G., Shon, J., Sickler, B., Batzoglou, S., Knudsen, K. E., He, H. H., Huang, J., Wyatt, A. W., Dehm, S. M., Ashworth, A., Chinnaiyan, A. M., Maher, C. A., Small, E. J. & Feng, F. Y., Oct 18 2018, In : Cell. 175, 3, 1 p.

Research output: Contribution to journalComment/debate

Genomic Structural Variation
Manuscripts
Amplification
Prostatic Neoplasms
Statistical tests
52 Citations (Scopus)

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

Quigley, D. A., Dang, H. X., Zhao, S. G., Lloyd, P., Aggarwal, R., Alumkal, J., Foye, A., Kothari, V., Perry, M. D., Bailey, A. M., Playdle, D., Barnard, T. J., Zhang, L., Zhang, J., Youngren, J. F., Cieslik, M. P., Parolia, A., Beer, T. T., Thomas, G., Chi, K. N. & 43 others, Gleave, M., Lack, N. A., Zoubeidi, A., Reiter, R. E., Rettig, M. B., Witte, O., Ryan, C. J., Fong, L., Kim, W., Friedlander, T., Chou, J., Li, H., Das, R., Li, H., Moussavi-Baygi, R., Goodarzi, H., Gilbert, L. A., Lara, P. N., Evans, C. P., Goldstein, T. C., Stuart, J. M., Tomlins, S. A., Spratt, D. E., Cheetham, R. K., Cheng, D. T., Farh, K., Gehring, J. S., Hakenberg, J., Liao, A., Febbo, P. G., Shon, J., Sickler, B., Batzoglou, S., Knudsen, K. E., He, H. H., Huang, J., Wyatt, A. W., Dehm, S. M., Ashworth, A., Chinnaiyan, A. M., Maher, C. A., Small, E. J. & Feng, F. Y., Jul 26 2018, In : Cell. 174, 3, p. 758-769.e9

Research output: Contribution to journalArticle

Genomic Structural Variation
Exome
Prostatic Neoplasms
Genes
Androgen Receptors
Oncology
Biopsy
Genes
Tumors
Testing
20 Citations (Scopus)

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Sehrawat, A., Gao, L., Wang, Y., Bankhead, A., McWeeney, S., King, C. J., Schwartzman, J., Urrutia, J., Bisson, W. H., Coleman, D. J., Joshi, S. K., Kim, D. H., Sampson, D. A., Weinmann, S., Kallakury, B. V. S., Berry, D. L., Haque, R., Van Den Eeden, S. K., Sharma, S., Bearss, J. & 4 others, Beer, T. T., Thomas, G., Heiser, L. & Alumkal, J., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. E4179-E4188

Research output: Contribution to journalArticle

Gene Regulatory Networks
Neoplasm Genes
Lysine
Prostatic Neoplasms
Castration

Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL

Chow, M., Gao, L., MacManiman, J. D., Bicocca, V. T., Chang, B., Alumkal, J. & Tyner, J., May 30 2018, (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journalArticle

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Protein Transport
B-Lymphoid Precursor Cells
Maintenance
Proteasome Endopeptidase Complex

Microsatellite Instability as an Emerging Biomarker for Checkpoint Inhibitor Response in Advanced Prostate Cancer

Reichert, Z. R., Urrutia, J. & Alumkal, J., Jan 1 2018, (Accepted/In press) In : JAMA oncology.

Research output: Contribution to journalArticle

Microsatellite Instability
Prostatic Neoplasms
Biomarkers
2017
52 Citations (Scopus)

Analysis of circulating cell-free DnA identifies multiclonal heterogeneity of BRCA2 reversion mutations associated with resistance to PARP inhibitors

Quigley, D., Alumkal, J., Wyatt, A. W., Kothari, V., Foye, A., Lloyd, P., Aggarwal, R., Kim, W., Lu, E., Schwartzman, J., Beja, K., Annala, M., Das, R., Diolaiti, M., Pritchard, C., Thomas, G., Tomlins, S., Knudsen, K., Lord, C. J., Ryan, C. & 5 others, Youngren, J., Beer, T. T., Ashworth, A., Small, E. J. & Feng, F. Y., Sep 1 2017, In : Cancer Discovery. 7, 9, p. 999-1005 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Recombinational DNA Repair
Mutation
DNA Repair
Biopsy
22 Citations (Scopus)

Androgen receptor mutations in patients with castration-resistant prostate cancer treated with apalutamide

Rathkopf, D. E., Smith, M. R., Ryan, C. J., Berry, W. R., Shore, N. D., Liu, G., Higano, C. S., Alumkal, J., Hauke, R., Tutrone, R. F., Saleh, M., Maneval, E. C., Thomas, S., Ricci, D. S., Yu, M. K., de Boer, C. J., Trinh, A., Kheoh, T., Bandekar, R., Scher, H. I. & 1 others, Antonarakis, E. S., 2017, In : Annals of Oncology. 28, 9, p. 2264-2271 8 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prednisone
Prostatic Neoplasms
Mutation
44 Citations (Scopus)

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer

Wyatt, A. W., Annala, M., Aggarwal, R., Beja, K., Feng, F., Youngren, J., Foye, A., Lloyd, P., Nykter, M., Beer, T. T., Alumkal, J., Thomas, G., Reiter, R. E., Rettig, M. B., Evans, C. P., Gao, A. C., Chi, K. N., Small, E. J. & Gleave, M. E., Dec 1 2017, In : Journal of the National Cancer Institute. 109, 12

Research output: Contribution to journalArticle

Prostatic Neoplasms
Biopsy
DNA
Neoplasms
Castration
10 Citations (Scopus)
Androgens
Survivors
Prostatic Neoplasms
Odds Ratio
Therapeutics
7 Citations (Scopus)

High-Dose Abiraterone Acetate in Men With Castration Resistant Prostate Cancer

Friedlander, T. W., Graff, J., Zejnullahu, K., Anantharaman, A., Zhang, L., Paz, R., Premasekharan, G., Russell, C., Huang, Y., Kim, W., Aggarwal, R. R., Lin, A. M., Fong, L., Alumkal, J., Beer, T. T., Sharifi, N., Alyamani, M., Dittamore, R., Small, E. J., Paris, P. L. & 1 others, Ryan, C. J., 2017, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Prostate-Specific Antigen
Therapeutics
Androgens
2 Citations (Scopus)

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer

King, C. J., Woodward, J., Schwartzman, J., Coleman, D. J., Lisac, R., Wang, N. J., Hook, K. V., Gao, L., Urrutia, J., Dane, M. A., Heiser, L. & Alumkal, J., Jan 1 2017, In : Oncotarget. 8, 67, p. 111084-111095 12 p.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Neoplasms
Drug Resistance
Genes
25 Citations (Scopus)

Phase II trial of the PI3 kinase inhibitor buparlisib (BKM-120) with or without enzalutamide in men with metastatic castration resistant prostate cancer

Armstrong, A. J., Halabi, S., Healy, P., Alumkal, J., Winters, C., Kephart, J., Bitting, R. L., Hobbs, C., Soleau, C. F., Beer, T. T., Slottke, R., Mundy, K., Yu, E. Y. & George, D. J., Aug 1 2017, In : European Journal of Cancer. 81, p. 228-236 9 p.

Research output: Contribution to journalArticle

Castration
Phosphatidylinositol 3-Kinases
docetaxel
Phosphatidylinositol 3-Kinase
Prostatic Neoplasms
14 Citations (Scopus)

Radiographic progression with nonrising PSA in metastatic castration-resistant prostate cancer: post hoc analysis of PREVAIL

Bryce, A. H., Alumkal, J., Armstrong, A., Higano, C. S., Iversen, P., Sternberg, C. N., Rathkopf, D., Loriot, Y., de Bono, J., Tombal, B., Abhyankar, S., Lin, P., Krivoshik, A., Phung, D. & Beer, T. T., Jan 24 2017, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Disease Progression
Prostatic Diseases
Androgen Receptors
38 Citations (Scopus)

Safety and antitumor activity of apalutamide (ARN-509) in metastatic castration-resistant prostate cancer with and without prior abiraterone acetate and prednisone

Rathkopf, D. E., Antonarakis, E. S., Shore, N. D., Tutrone, R. F., Alumkal, J., Ryan, C. J., Saleh, M., Hauke, R. J., Bandekar, R., Maneval, E. C., De Boer, C. J., Yu, M. K. & Scher, H. I., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3544-3551 8 p.

Research output: Contribution to journalArticle

Castration
Prednisone
Prostatic Neoplasms
Safety
Prostate-Specific Antigen
2 Citations (Scopus)

Should Chemotherapy Be Used in Nonmetastatic Prostate Cancer?

Graff, J., Alumkal, J. & Beer, T. T., Jan 1 2017, In : JAMA oncology. 3, 1, p. 11-12 2 p.

Research output: Contribution to journalArticle

Taxoids
Disease-Free Survival
Prostatic Neoplasms
Neoplasm Metastasis
Drug Therapy
2016
7 Citations (Scopus)

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor

Coleman, D. J., Van Hook, K., King, C. J., Schwartzman, J., Lisac, R., Urrutia, J., Sehrawat, A., Woodward, J., Wang, N. J., Gulati, R., Thomas, G., Beer, T. T., Gleave, M., Korkola, J., Gao, L., Heiser, L. & Alumkal, J., 2016, In : Oncotarget. 7, 26, p. 40690 1 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Castration
Prostatic Neoplasms
MDV 3100
11 Citations (Scopus)

CT-Guided Bone Biopsies in Metastatic Castration-Resistant Prostate Cancer: Factors Predictive of Maximum Tumor Yield

Holmes, M. G., Foss, E., Joseph, G., Foye, A., Beckett, B., Motamedi, D., Youngren, J., Thomas, G., Huang, J., Aggarwal, R., Alumkal, J., Beer, T. T., Small, E. J. & Link, T. M., Dec 19 2016, (Accepted/In press) In : Journal of Vascular and Interventional Radiology.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Biopsy
Bone and Bones
Neoplasms
152 Citations (Scopus)

Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer

Graff, J., Alumkal, J., Drake, C. G., Thomas, G., Redmond, W. L., Farhad, M., Cetnar, J., Ey, F. F., Bergan, R., Slottke, R. & Beer, T. T., Aug 1 2016, In : Oncotarget. 7, 33, p. 52810-52817 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Cell Death
Castration
Hypothyroidism
Biopsy
6 Citations (Scopus)

Effect of Visceral Disease Site on Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer Treated With Enzalutamide in the PREVAIL Trial

Alumkal, J., Chowdhury, S., Loriot, Y., Sternberg, C. N., de Bono, J. S., Tombal, B., Carles, J., Flaig, T. W., Dorff, T. B., Phung, D., Forer, D., Noonberg, S. B., Mansbach, H., Beer, T. T. & Higano, C. S., Dec 14 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Neoplasm Metastasis
Liver
Lung
52 Citations (Scopus)

Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort

Smith, M. R., Antonarakis, E. S., Ryan, C. J., Berry, W. R., Shore, N. D., Liu, G., Alumkal, J., Higano, C. S., Chow Maneval, E., Bandekar, R., de Boer, C. J., Yu, M. K. & Rathkopf, D. E., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Androgen Receptor Antagonists
Castration
Prostatic Neoplasms
Prostate-Specific Antigen
Safety
2 Citations (Scopus)

Raising the bar for therapeutic trials in advanced prostate cancer

Alumkal, J. & Beer, T. T., Sep 1 2016, In : Journal of Clinical Oncology. 34, 25, p. 2958-2960 3 p.

Research output: Contribution to journalReview article

Prostatic Neoplasms
Therapeutics
5 Citations (Scopus)

Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation–Supported West Coast Prostate Cancer Dream Team

Aggarwal, R., Beer, T. T., Gleave, M., Stuart, J. M., Rettig, M., Evans, C. P., Youngren, J., Alumkal, J., Huang, J., Thomas, G., Witte, O. & Small, E. J., Dec 1 2016, In : European Urology Focus. 2, 5, p. 469-471 3 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Castration
Biopsy
Therapeutics
Population
2015
68 Citations (Scopus)

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

Alumkal, J., Slottke, R., Schwartzman, J., Cherala, G., Munar, M., Graff, J., Beer, T. T., Ryan, C., Koop, D., Gibbs, A., Gao, L., Flamiatos, J. F., Tucker, E., Kleinschmidt, R. & Mori, M. T., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 480-489 10 p.

Research output: Contribution to journalArticle

Brassica
Prostatic Neoplasms
Vegetables
Diet
Prostate
24 Citations (Scopus)

AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - Results of two parallel first-in-human phase I studies

Omlin, A., Jones, R. J., Van Der Noll, R., Satoh, T., Niwakawa, M., Smith, S. A., Graham, J., Ong, M., Finkelman, R. D., Schellens, J. H. M., Zivi, A., Crespo, M., Riisnaes, R., Nava-Rodrigues, D., Malone, M. D., Dive, C., Sloane, R., Moore, D., Alumkal, J., Dymond, A. & 5 others, Dickinson, P. A., Ranson, M., Clack, G., De Bono, J. & Elliott, T., Apr 30 2015, In : Investigational New Drugs. 33, 3, p. 679-690 12 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Appointments and Schedules
Nausea
35 Citations (Scopus)

Castration-resistant prostate cancer bone metastasis response measured by 18F-fluoride PET after treatment with dasatinib and correlation with progression-free survival: Results from American College of Radiology Imaging Network 6687

Yu, E. Y., Duan, F., Muzi, M., Deng, X., Chin, B. B., Alumkal, J., Taplin, M. E., Taub, J. M., Herman, B., Higano, C. S., Doot, R. K., Hartfeil, D., Febbo, P. G. & Mankoff, D. A., Mar 1 2015, In : Journal of Nuclear Medicine. 56, 3, p. 354-360 7 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Castration
Fluorides
Radiology
Disease-Free Survival
10 Citations (Scopus)

CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer

Guo, M., Alumkal, J., Drachova, T., Gao, D., Marina, S. S., Jen, J. & Herman, J. G., 2015, In : Discovery medicine. 19, 104, p. 151-158 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
DNA Repair
Methylation
DNA Damage
Genes
14 Citations (Scopus)

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2: ERG fusion-positive versus fusion-negative tumors

Geybels, M. S., Alumkal, J., Luedeke, M., Rinckleb, A., Zhao, S., Shui, I. M., Bibikova, M., Klotzle, B., van den Brandt, P. A., Ostrander, E. A., Fan, J. B., Feng, Z., Maier, C. & Stanford, J. L., Dec 12 2015, In : Clinical Epigenetics. 7, 1, 128.

Research output: Contribution to journalArticle

Epigenomics
Prostatic Neoplasms
Genes
Neoplasms
DNA Methylation
5 Citations (Scopus)
docetaxel
Castration
Proxy
Granulocyte-Macrophage Colony-Stimulating Factor
Prednisone
2014
7 Citations (Scopus)

Diagnostic and prognostic utility of a DNA hypermethylated gene signature in prostate cancer

Goh, L. K., Liem, N., Vijayaraghavan, A., Chen, G., Lim, P. L., Tay, K. J., Chang, M., Low, J. S. W., Joshi, A., Huang, H. H., Kalaw, E., Tan, P. H., Hsieh, W. S., Yong, W. P., Alumkal, J. & Sim, H. G., Mar 13 2014, In : PLoS One. 9, 3, e91666.

Research output: Contribution to journalArticle

Methylation
prostatic neoplasms
Microarrays
hyperplasia
bisulfites
6 Citations (Scopus)

Orteronel for the treatment of prostate cancer

Van Hook, K., Huang, T. & Alumkal, J., 2014, In : Future Oncology. 10, 5, p. 803-811 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Androgens
docetaxel
Therapeutics
Testis
25 Citations (Scopus)

Phase II study of single-agent orteronel (TAK-700) in patients with nonmetastatic castration-resistant prostate cancer and rising prostate-specific antigen

Hussain, M., Corn, P. G., Michaelson, M. D., Hammers, H. J., Alumkal, J., Ryan, C. J., Bruce, J. Y., Moran, S., Lee, S. Y., Lin, H. M. & George, D. J., Aug 15 2014, In : Clinical Cancer Research. 20, 16, p. 4218-4227 10 p.

Research output: Contribution to journalArticle

Castration
Prostate-Specific Antigen
Prostatic Neoplasms
Neoplasm Metastasis
Steroids
39 Citations (Scopus)

Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer

Hussain, M., Carducci, M. A., Slovin, S., Cetnar, J., Qian, J., McKeegan, E. M., Refici-Buhr, M., Chyla, B., Shepherd, S. P., Giranda, V. L. & Alumkal, J., Apr 26 2014, In : Investigational New Drugs. 32, 5, p. 904-912 9 p.

Research output: Contribution to journalArticle

temozolomide
Castration
Prostate-Specific Antigen
DNA Repair
Prostatic Neoplasms
2013
61 Citations (Scopus)

Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

Gao, L., Schwartzman, J., Gibbs, A., Lisac, R., Kleinschmidt, R., Wilmot, B., Bottomly, D., Coleman, I., Nelson, P., McWeeney, S. & Alumkal, J., May 21 2013, In : PLoS One. 8, 5, e63563.

Research output: Contribution to journalArticle

Androgen Receptors
prostatic neoplasms
Prostatic Neoplasms
Up-Regulation
Ligands
6 Citations (Scopus)

Immunohistochemical expression of ERG in the molecular epidemiology of fatal prostate cancer study

Weinmann, S., Van Den Eeden, S. K., Haque, R., Chen, C., Richert-Boe, K., Schwartzman, J., Gao, L., Berry, D. L., Kallakury, B. V. S. & Alumkal, J., Sep 2013, In : Prostate. 73, 13, p. 1371-1377 7 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Prostatic Neoplasms
Immunohistochemistry
Confidence Intervals
Mortality
323 Citations (Scopus)

Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase i/ii study

Slovin, S. F., Higano, C. S., Hamid, O., Tejwani, S., Harzstark, A., Alumkal, J., Scher, H. I., Chin, K., Gagnier, P., McHenry, M. B. & Beer, T. T., Jul 2013, In : Annals of Oncology. 24, 7, p. 1813-1821 9 p., mdt107.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Radiotherapy
Colitis
Prostate-Specific Antigen
52 Citations (Scopus)

Targeted MET inhibition in castration-resistant prostate cancer: A randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone

Ryan, C. J., Rosenthal, M., Ng, S., Alumkal, J., Picus, J., Gravis, G., Fizazi, K., Forget, F., Machiels, J. P., Srinivas, S., Zhu, M., Tang, R., Oliner, K. S., Jiang, Y., Loh, E., Dubey, S. & Gerritsen, W. R., Jan 1 2013, In : Clinical Cancer Research. 19, 1, p. 215-224 10 p.

Research output: Contribution to journalArticle

Mitoxantrone
Castration
Prednisone
Prostatic Neoplasms
Biomarkers
1 Citation (Scopus)
Androgen Receptors
Prostatic Neoplasms
Therapeutics
2012
45 Citations (Scopus)

C-reactive protein as an adverse prognostic marker for men with castration-resistant prostate cancer (CRPC): Confirmatory results

Prins, R. C., Rademacher, B. L., Mongoue-Tchokote, S., Alumkal, J., Graff, J., Eilers, K. M. & Beer, T. T., Jan 2012, In : Urologic Oncology: Seminars and Original Investigations. 30, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

Castration
C-Reactive Protein
Prostatic Neoplasms
Survival
Proportional Hazards Models