Joseph El Youssef

Assistant Professor

  • 724 Citations
  • 15 h-Index
20042019
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Research Output 2004 2019

  • 724 Citations
  • 15 h-Index
  • 34 Article
  • 1 Conference contribution
  • 1 Comment/debate
2019

Adaptive tuning of basal and bolus insulin to reduce postprandial hypoglycemia in a hybrid artificial pancreas

Resalat, N., El Youssef, J., Reddy, R., Castle, J. & Jacobs, P., Aug 1 2019, In : Journal of Process Control. 80, p. 247-254 8 p.

Research output: Contribution to journalArticle

Insulin
Adaptive Learning
Tuning
Diabetes
Medical problems
1 Citation (Scopus)

A statistical virtual patient population for the glucoregulatory system in type 1 diabetes with integrated exercise model

Resalat, N., El Youssef, J., Tyler, N., Castle, J. & Jacobs, P., Jan 1 2019, In : PloS one. 14, 7, e0217301.

Research output: Contribution to journalArticle

Open Access
insulin-dependent diabetes mellitus
Medical problems
Type 1 Diabetes Mellitus
exercise
Hormones

Prediction of Hypoglycemia During Aerobic Exercise in Adults With Type 1 Diabetes

Reddy, R., Resalat, N., Wilson, L. M., Castle, J., El Youssef, J. & Jacobs, P., Jan 1 2019, In : Journal of diabetes science and technology.

Research output: Contribution to journalArticle

Medical problems
Type 1 Diabetes Mellitus
Hypoglycemia
Exercise
Heart Rate
2018
2 Citations (Scopus)

Accuracy of wrist-worn activity monitors during common daily physical activities and types of structured exercise: Evaluation study

Kondama Reddy, R., Pooni, R., Zaharieva, D. P., Senf, B., El Youssef, J., Dassau, E., Doyle, F. J., Clements, M. A., Rickels, M. R., Patton, S. R., Castle, J., Riddell, M. C. & Jacobs, P., Dec 1 2018, In : JMIR mHealth and uHealth. 6, 12, e10338.

Research output: Contribution to journalArticle

Wrist
Heart Rate
Exercise
Energy Metabolism
Indirect Calorimetry
1 Citation (Scopus)

Effect of Aerobic and Resistance Exercise on Glycemic Control in Adults With Type 1 Diabetes

Reddy, R., Wittenberg, A., Castle, J., El Youssef, J., Winters-Stone, K., Gillingham, M. & Jacobs, P., Jan 1 2018, (Accepted/In press) In : Canadian Journal of Diabetes.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Exercise
Resistance Training
Glucose
Glycosylated Hemoglobin A
23 Citations (Scopus)

Randomized Outpatient Trial of Single- and Dual-Hormone Closed-Loop Systems That Adapt to Exercise Using Wearable Sensors

Castle, J., El Youssef, J., Wilson, L. M., Reddy, R., Resalat, N., Branigan, D., Ramsey, K., Leitschuh, J., Rajhbeharrysingh, U., Senf, B., Sugerman, S. M., Gabo, V. & Jacobs, P., Jul 1 2018, In : Diabetes Care. 41, 7, p. 1471-1477 7 p.

Research output: Contribution to journalArticle

Outpatients
Hormones
Exercise
Hypoglycemia
Type 1 Diabetes Mellitus
7 Citations (Scopus)

The effect of exercise on sleep in adults with type 1 diabetes

Reddy, R., El Youssef, J., Winters-Stone, K., Branigan, D., Leitschuh, J., Castle, J. & Jacobs, P., Feb 1 2018, In : Diabetes, Obesity and Metabolism. 20, 2, p. 443-447 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Sleep
Hypoglycemia
Exercise
Wrist
2017
5 Citations (Scopus)

Evaluation of model complexity in model predictive control within an exercise-enabled artificial pancreas

Resalat, N., El Youssef, J., Reddy, R. & Jacobs, P., Jul 1 2017, In : IFAC-PapersOnLine. 50, 1, p. 7756-7761 6 p.

Research output: Contribution to journalArticle

Model predictive control
Controllers
Insulin
Glucose
2 Citations (Scopus)

Modeling Glucagon Action in Patients with Type 1 Diabetes

Emami, A., El Youssef, J., Rabasa-Lhoret, R., Pineau, J., Castle, J. & Haidar, A., Jul 1 2017, In : IEEE Journal of Biomedical and Health Informatics. 21, 4, p. 1163-1171 9 p., 7517341.

Research output: Contribution to journalArticle

Medical problems
Glucagon
Type 1 Diabetes Mellitus
Insulin
Glucose
2016
19 Citations (Scopus)

Comparative pharmacokinetic/pharmacodynamic study of liquid stable glucagon versus lyophilized glucagon in type 1 diabetes subjects

Castle, J., El Youssef, J., Branigan, D., Newswanger, B., Strange, P., Cummins, M., Shi, L. & Prestrelski, S., 2016, In : Journal of diabetes science and technology. 10, 5, p. 1101-1107 7 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Medical problems
Glucagon
Type 1 Diabetes Mellitus
6 Citations (Scopus)

Design of a dual-hormone model predictive control for artificial pancreas with exercise model

Resalat, N., El Youssef, J., Reddy, R. & Jacobs, P., Oct 13 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., Vol. 2016-October. p. 2270-2273 4 p. 7591182

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Artificial Pancreas
Hormones
Model predictive control
Exercise
Glucagon
2 Citations (Scopus)
Nomograms
Secondary Hyperparathyroidism
Primary Hyperparathyroidism
Parathyroid Hormone
Bariatric Surgery
3 Citations (Scopus)

IN CONTROL of type 1 diabetes, despite hypoglycaemia unawareness

El Youssef, J., Nov 1 2016, In : The Lancet Diabetes and Endocrinology. 4, 11, p. 874-875 2 p.

Research output: Contribution to journalComment/debate

Type 1 Diabetes Mellitus
Hypoglycemia
47 Citations (Scopus)

Randomized trial of a dual-hormone artificial pancreas with dosing adjustment during exercise compared with no adjustment and sensor-augmented pump therapy

Jacobs, P., El Youssef, J., Reddy, R., Resalat, N., Branigan, D., Condon, J., Preiser, N., Ramsey, K., Jones, M., Edwards, C., Kuehl, K., Leitschuh, J., Rajhbeharrysingh, U. & Castle, J., 2016, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Artificial Pancreas
Hormones
Glucagon
Hypoglycemia
Insulin
2015
15 Citations (Scopus)

A novel, stable, aqueous Glucagon formulation using Ferulic acid as an Excipient

Bakhtiani, P. A., Caputo, N., Castle, J., El Youssef, J., Carroll, J. M., David, L., Roberts, C. & Kenneth, W., Jan 1 2015, In : Journal of diabetes science and technology. 9, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

ferulic acid
Excipients
Glucagon
Acids
Agglomeration
15 Citations (Scopus)

Effect of repeated glucagon doses on hepatic glycogen in type 1 Diabetes: Implications for a bihormonal Closed-Loop system

Castle, J., El Youssef, J., Bakhtiani, P. A., Cai, Y., Stobbe, J. M., Branigan, D., Ramsey, K., Jacobs, P., Reddy, R., Woods, M. & Ward, W. K., Nov 1 2015, In : Diabetes Care. 38, 11, p. 2115-2119 5 p.

Research output: Contribution to journalArticle

Liver Glycogen
Glucagon
Type 1 Diabetes Mellitus
Glycogen
Fasting
10 Citations (Scopus)

Factors affecting the success of glucagon delivered during an automated closed-loop system in type 1 diabetes

Bakhtiani, P. A., El Youssef, J., Duell, A. K., Branigan, D. L., Jacobs, P., Lasarev, M. R., Castle, J. & Ward, W. K., Jan 1 2015, In : Journal of Diabetes and its Complications. 29, 1, p. 93-98 6 p.

Research output: Contribution to journalArticle

Glucagon
Type 1 Diabetes Mellitus
Hypoglycemia
Hypoglycemic Agents
Glucose
35 Citations (Scopus)

Incorporating an exercise detection, grading, and hormone dosing algorithm into the artificial pancreas using accelerometry and heart rate

Jacobs, P., Resalat, N., El Youssef, J., Reddy, R., Branigan, D., Preiser, N., Condon, J. & Castle, J., Nov 1 2015, In : Journal of diabetes science and technology. 9, 6, p. 1175-1184 10 p.

Research output: Contribution to journalArticle

Artificial Pancreas
Accelerometry
Hormones
Heart Rate
Exercise
2 Citations (Scopus)

Treatment challenges for the young patient with type 1 diabetes

El Youssef, J. & Ward, W. K., Jun 1 2015, In : Diabetes Technology and Therapeutics. 17, 6, p. 367-369 3 p.

Research output: Contribution to journalArticle

Patient Acceptance of Health Care
Blood Glucose Self-Monitoring
Type 1 Diabetes Mellitus
Therapeutics
2014
46 Citations (Scopus)

Automated control of an adaptive bihormonal, dual-sensor artificial pancreas and evaluation during inpatient studies

Jacobs, P., El Youssef, J., Castle, J., Bakhtiani, P., Branigan, D., Breen, M., Bauer, D., Preiser, N., Leonard, G., Stonex, T. & Ward, W. K., Oct 1 2014, In : IEEE Transactions on Biomedical Engineering. 61, 10, p. 2569-2581 13 p., 6814769.

Research output: Contribution to journalArticle

Glucose
Insulin
Sensors
Glucose sensors
Hormones
10 Citations (Scopus)

Biochemical stabilization of glucagon at alkaline pH

Caputo, N., Jackson, M. A., Castle, J., El Youssef, J., Bakhtiani, P. A., Bergstrom, C. P., Carroll, J. M., Breen, M. E., Leonard, G. L., David, L., Roberts, C. & Ward, W. K., 2014, In : Diabetes Technology and Therapeutics. 16, 11, p. 747-758 12 p.

Research output: Contribution to journalArticle

Glucagon
Insulin Infusion Systems
Curcumin
Excipients
Albumins
29 Citations (Scopus)

Quantification of the glycemic response to microdoses of subcutaneous glucagon at varying insulin levels

El Youssef, J., Castle, J., Bakhtiani, P. A., Haidar, A., Branigan, D. L., Breen, M. & Ward, W. K., Nov 1 2014, In : Diabetes Care. 37, 11, p. 3054-3060 7 p.

Research output: Contribution to journalArticle

Glucagon
Insulin
Glucose
Type 1 Diabetes Mellitus
Hypoglycemia
2013

A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroidinduced stress hyperglycemia in type 1 diabetes

El Castle, J., El Youssef, J., Branigan, D. L., Massoud, R. G., Breen, M. E., Jacobs, P., Bequette, B. W. & Ward, W. K., Jun 1 2013, In : Diabetes Technology and Therapeutics. 15, SUPPL.1

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Hyperglycemia
44 Citations (Scopus)

A review of artificial pancreas technologies with an emphasis on bi-hormonal therapy

Bakhtiani, P. A., Zhao, L. M., El Youssef, J., Castle, J. & Ward, W. K., Dec 2013, In : Diabetes, Obesity and Metabolism. 15, 12, p. 1065-1070 6 p.

Research output: Contribution to journalArticle

Artificial Pancreas
Glucagon
Technology
Insulin
Type 1 Diabetes Mellitus
2012
7 Citations (Scopus)

Discomfort from an alkaline formulation delivered subcutaneously in humans: Albumin at pH 7 versus pH 10

Ward, W. K., Castle, J., Branigan, D. L., Massoud, R. G. & El Youssef, J., 2012, In : Clinical Drug Investigation. 32, 7, p. 433-438 6 p.

Research output: Contribution to journalArticle

Albumins
Injections
Pharmaceutical Preparations
Inflammation
Glycine
30 Citations (Scopus)

The accuracy benefit of multiple amperometric glucose sensors in people with type 1 diabetes

Castle, J., Pitts, A., Hanavan, K., Muhly, R., El Youssef, J., Hughes-Karvetski, C., Kovatchev, B. & Ward, W. K., Apr 2012, In : Diabetes Care. 35, 4, p. 706-710 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Glucose
Artificial Pancreas
Abdomen
Blood Glucose
15 Citations (Scopus)

The effect of rising vs. falling glucose level on amperometric glucose sensor lag and accuracy in Type1 diabetes

Ward, W. K., Engle, J. M., Branigan, D., El Youssef, J., Massoud, R. G. & Castle, J., Aug 2012, In : Diabetic Medicine. 29, 8, p. 1067-1073 7 p.

Research output: Contribution to journalArticle

Glucose
Blood Glucose
Accidental Falls
Calibration
Noise
2011
26 Citations (Scopus)

A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetes

El Youssef, J., Castle, J., Branigan, D. L., Massoud, R. G., Breen, M. E., Jacobs, P., Bequette, B. W. & Ward, W. K., 2011, In : Journal of diabetes science and technology. 5, 6, p. 1312-1326 15 p.

Research output: Contribution to journalArticle

Medical problems
Type 1 Diabetes Mellitus
Hyperglycemia
Adrenal Cortex Hormones
Insulin
15 Citations (Scopus)
Artificial Pancreas
Insulin
Glucagon
Blood Glucose
Sugars
27 Citations (Scopus)
Insulin
Medical problems
Glucagon
Type 1 Diabetes Mellitus
Hyperglycemia
2010
13 Citations (Scopus)

Continuous glucose monitoring in subjects with type 1 diabetes: Improvement in accuracy by correcting for background current

El Youssef, J., Castle, J., Engle, J. M., Massoud, R. G. & Ward, W. K., Nov 1 2010, In : Diabetes Technology and Therapeutics. 12, 11, p. 921-928 8 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Glucose
Calibration
Hypoglycemia
Hyperglycemia
29 Citations (Scopus)

Factors influencing the effectiveness of glucagon for preventing hypoglycemia

Castle, J., Engle, J. M., El Youssef, J., Massoud, R. G. & Ward, W. K., Nov 2010, In : Journal of diabetes science and technology. 4, 6, p. 1305-1310 6 p.

Research output: Contribution to journalArticle

Insulin
Glucagon
Hypoglycemia
Glucose
Sensors
20 Citations (Scopus)

In vitro and in vivo evaluation of native glucagon and glucagon analog (MAR-D28) during aging: Lack of cytotoxicity and preservation of hyperglycemic effect

Ward, W. K., Massoud, R. G., Szybala, C. J., Engle, J. M., El Youssef, J., Carroll, J. M., Roberts, C. & DiMarchi, R. D., Nov 2010, In : Journal of diabetes science and technology. 4, 6, p. 1311-1321 11 p.

Research output: Contribution to journalArticle

Cytotoxicity
Glucagon
Aging of materials
Amino acids
Size exclusion chromatography
172 Citations (Scopus)

Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes

Castle, J., Engle, J. M., El Youssef, J., Massoud, R. G., Yuen, K. C. J., Kagan, R. & Ward, W. K., Jun 2010, In : Diabetes Care. 33, 6, p. 1282-1287 6 p.

Research output: Contribution to journalArticle

Glucagon
Type 1 Diabetes Mellitus
Hypoglycemia
Insulin
Hypoglycemic Agents
2009
35 Citations (Scopus)

A review of closed-loop algorithms for glycemic control in the treatment of type 1 diabetes

El Youssef, J., Castle, J. & Ward, W. K., Mar 2009, In : Algorithms. 2, 1, p. 518-532 15 p.

Research output: Contribution to journalArticle

Insulin
Diabetes
Medical problems
Closed-loop
Glucose
2004
11 Citations (Scopus)

Prolonged inadvertent pravastatin use in pregnancy

Teelucksingh, S., El Youssef, J., Sohan, K. & Ramsewak, S., Mar 2004, In : Reproductive Toxicology. 18, 2, p. 299-300 2 p.

Research output: Contribution to journalArticle

Anticholesteremic Agents
Pravastatin