Joseph Doggett

Assistant Professor

  • 398 Citations
  • 11 h-Index
20082019
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Research Output 2008 2019

  • 398 Citations
  • 11 h-Index
  • 16 Article
  • 6 Chapter
  • 2 Review article

Acute suppurative thyroiditis

Doggett, J. & Wong, B., Jan 1 2014, Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., p. 109-113 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suppurative Thyroiditis
11 Citations (Scopus)

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

Kirkman, L. A., Zhan, W., Visone, J., Dziedziech, A., Singh, P. K., Fan, H., Tong, X., Bruzual, I., Hara, R., Kawasaki, M., Imaeda, T., Okamoto, R., Sato, K., Michino, M., Alvaro, E. F., Guiang, L. F., Sanz, L., Mota, D. J., Govindasamy, K., Wang, R. & 14 others, Ling, Y., Tumwebaze, P. K., Sukenick, G., Shi, L., Vendome, J., Bhanot, P., Rosenthal, P. J., Aso, K., Foley, M. A., Cooper, R. A., Kafsack, B., Doggett, J., Nathan, C. F. & Lin, G., Jul 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 29, p. E6863-E6870

Research output: Contribution to journalReview article

Open Access
ethylenediamine
Proteasome Inhibitors
Antimalarials
Plasmodium falciparum
Asparagine
2 Citations (Scopus)

BmGPAC, an antigen capture assay for detection of active babesia microti infection

Thekkiniath, J., Mootien, S., Lawres, L., Perrin, B. A., Gewirtz, M., Krause, P. J., Williams, S., Doggett, J., Ledizet, M. & Mamoun, C. B., Oct 1 2018, In : Journal of Clinical Microbiology. 56, 10, e00067.

Research output: Contribution to journalArticle

Babesia microti
Antigens
Infection
Babesiosis
Microscopy
35 Citations (Scopus)

Bumped kinase inhibitor 1294 treats established toxoplasma gondii infection

Doggett, J., Ojo, K. K., Fan, E., Maly, D. J. & Van Voorhis, W. C., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 6, p. 3547-3549 3 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Toxoplasma
Phosphotransferases
Cryptosporidium
Plasmodium
10 Citations (Scopus)

Cystic neutrophilic granulomatous mastitis: Association with gram-positive bacilli and corynebacterium

Troxell, M., Gordon, N. T., Doggett, J., Ballard, M., Vetto, J., Pommier, R. & Naik, A., May 1 2016, In : American Journal of Clinical Pathology. 145, 5, p. 635-645 11 p.

Research output: Contribution to journalArticle

Granulomatous Mastitis
Corynebacterium
Bacillus
Hispanic Americans
40 Citations (Scopus)

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

Vidadala, R. S. R., Rivas, K. L., Ojo, K. K., Hulverson, M. A., Zambriski, J. A., Bruzual, I., Schultz, T. L., Huang, W., Zhang, Z., Scheele, S., DeRocher, A. E., Choi, R., Barrett, L. K., Siddaramaiah, L. K., Hol, W. G. J., Fan, E., Merritt, E. A., Parsons, M., Freiberg, G., Marsh, K. & 6 others, Kempf, D. J., Carruthers, V. B., Isoherranen, N., Doggett, J., Van Voorhis, W. C. & Maly, D. J., Jul 14 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6531-6546 16 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Toxoplasma
Protein Kinase Inhibitors
Ether
Central Nervous System
61 Citations (Scopus)

Discovery, synthesis, and optimization of antimalarial 4(1 H)-quinolone-3-diarylethers

Nilsen, A., Miley, G. P., Forquer, I. P., Mather, M. W., Katneni, K., Li, Y., Pou, S., Pershing, A. M., Stickles, A. M., Ryan, E., Kelly, J. X., Doggett, J., White, K. L., Hinrichs, D. J., Winter, R. W., Charman, S. A., Zakharov, L. N., Bathurst, I., Burrows, J. N., Vaidya, A. B. & 1 others, Riscoe, M., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3818-3834 17 p.

Research output: Contribution to journalArticle

Quinolones
Antimalarials
Atovaquone
4-Quinolones
Falciparum Malaria
22 Citations (Scopus)
Mycobacterium
Kidney
Lung
Acquired Immunodeficiency Syndrome
HIV
43 Citations (Scopus)

Drugs in development for toxoplasmosis: Advances, challenges, and current status

Alday, P. H. & Doggett, J., Jan 25 2017, In : Drug Design, Development and Therapy. 11, p. 273-293 21 p.

Research output: Contribution to journalReview article

Toxoplasmosis
Pharmaceutical Preparations
Toxoplasma
Cysts
Eye Diseases

Emphysematous cholecystitis

Doggett, J. & Wong, B., Jan 1 2014, Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., p. 65-69 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Emphysematous Cholecystitis

Emphysematous pyelonephritis

Wong, B. & Doggett, J., Jan 1 2014, Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., p. 71-76 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pyelonephritis
75 Citations (Scopus)

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Doggett, J., Nilsen, A., Forquer, I., Wegmann, K. W., Jones-Brando, L., Yolken, R. H., Bordón, C., Charman, S. A., Katneni, K., Schultz, T., Burrows, J. N., Hinrichs, D. J., Meunier, B., Carruthers, V. B. & Riscoe, M., Sep 25 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 39, p. 15936-15941 6 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Quinolones
Toxoplasma
Qi
Electron Transport Complex III

Endochin-like quinolones exhibit promising efficacy against neospora caninum in vitro and in experimentally infected pregnant mice

Anghel, N., Balmer, V., Müller, J., Winzer, P., Aguado-Martinez, A., Roozbehani, M., Pou, S., Nilsen, A., Riscoe, M., Doggett, J. & Hemphill, A., Nov 19 2018, In : Frontiers in Veterinary Science. 5, NOV, 285.

Research output: Contribution to journalArticle

Neospora
quinolones
Neospora caninum
Quinolones
mice
14 Citations (Scopus)

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review

Van Voorhis, W. C., Doggett, J., Parsons, M., Hulverson, M. A., Choi, R., Arnold, S., Riggs, M. W., Hemphill, A., Howe, D. K., Mealey, R. H., Lau, A. O. T., Merritt, E. A., Maly, D. J., Fan, E. & Ojo, K. K., 2017, (Accepted/In press) In : Experimental Parasitology.

Research output: Contribution to journalArticle

Parasites
Phosphotransferases
Protein Kinases
Parasitic Diseases
Life Cycle Stages
17 Citations (Scopus)

Genetic evidence for cytochrome b Qi site inhibition by 4(1H)-quinolone-3-diarylethers and antimycin in Toxoplasma gondii

Alday, P. H., Bruzual, I., Nilsen, A., Pou, S., Winter, R., Mamoun, C. B., Riscoe, M. & Doggett, J., Feb 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 2, e01866.

Research output: Contribution to journalArticle

4-Quinolones
Qi
Cytochromes b
Quinolones
Toxoplasma
7 Citations (Scopus)

Lyme disease in Oregon

Doggett, J., Kohlhepp, S., Gresbrink, R., Metz, P., Gleaves, C. & Gilbert, D., Jun 2008, In : Journal of Clinical Microbiology. 46, 6, p. 2115-2118 4 p.

Research output: Contribution to journalArticle

Lyme Disease
Ticks
Ixodes
Incidence
Health

Malignant (necrotizing) otitis externa

Doggett, J. & Wong, B., Jan 1 2014, Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., p. 49-55 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Otitis Externa
1 Citation (Scopus)

Mucormycosis

Doggett, J. & Wong, B., Jan 1 2014, Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., p. 57-63 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mucormycosis

Necrotizing soft tissue infections

Doggett, J. & Wong, B., Jan 1 2014, Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., p. 43-48 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Soft Tissue Infections
1 Citation (Scopus)

Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis

Hulverson, M. A., Bruzual, I., McConnell, E. V., Huang, W., Vidadala, R. S. R., Choi, R., Arnold, S. L. M., Whitman, G. R., McCloskey, M. C., Barrett, L. K., Rivas, K. L., Scheele, S., DeRocher, A. E., Parsons, M., Ojo, K. K., Maly, D. J., Fan, E., Van Voorhis, W. C. & Doggett, J., Apr 16 2019, In : The Journal of infectious diseases. 219, 9, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

Open Access
Toxoplasmosis
Phosphotransferases
Pharmacokinetics
Toxoplasma
Poisons
22 Citations (Scopus)

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone

Lawres, L. A., Garg, A., Kumar, V., Bruzual, I., Forquer, I. P., Renard, I., Virji, A. Z., Boulard, P., Rodriguez, E. X., Allen, A. J., Pou, S., Wegmann, K. W., Winter, R. W., Nilsen, A., Mao, J., Preston, D. A., Belperron, A. A., Bockenstedt, L. K., Hinrichs, D. J., Riscoe, M. & 2 others, Doggett, J. & Mamoun, C. B., 2016, In : Journal of Experimental Medicine. 213, 7, p. 1307-1318 12 p.

Research output: Contribution to journalArticle

Atovaquone
Babesiosis
Quinolones
Parasites
Prodrugs
22 Citations (Scopus)

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Huang, W., Ojo, K. K., Zhang, Z., Rivas, K., Vidadala, R. S. R., Scheele, S., Derocher, A. E., Choi, R., Hulverson, M. A., Barrett, L. K., Bruzual, I., Siddaramaiah, L. K., Kerchner, K. M., Kurnick, M. D., Freiberg, G. M., Kempf, D., Hol, W. G. J., Merritt, E. A., Neckermann, G., De Hostos, E. L. & 6 others, Isoherranen, N., Maly, D. J., Parsons, M., Doggett, J., Van Voorhis, W. C. & Fan, E., Dec 10 2015, In : ACS Medicinal Chemistry Letters. 6, 12, p. 1184-1189 6 p.

Research output: Contribution to journalArticle

Toxoplasma
Ascitic Fluid
Fluids
Scaffolds
Brain
10 Citations (Scopus)

Sontochin as a guide to the development of drugs against chloroquine-resistant malaria

Pou, S., Winter, R. W., Nilsen, A., Kelly, J. X., Li, Y., Doggett, J., Riscoe, E. W., Wegmann, K. W., Hinrichs, D. J. & Riscoe, M., Jul 2012, In : Antimicrobial Agents and Chemotherapy. 56, 7, p. 3475-3480 6 p.

Research output: Contribution to journalArticle

Chloroquine
Malaria
Pharmaceutical Preparations
Plasmodium yoelii
Poisons
5 Citations (Scopus)

Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

McConnell, E. V., Bruzual, I., Pou, S., Winter, R., Dodean, R. A., Smilkstein, M. J., Krollenbrock, A., Nilsen, A., Zakharov, L. N., Riscoe, M. & Doggett, J., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Qi
4-Quinolones
Electron Transport Complex III
Toxoplasmosis
Quinolones