John Jr Crabbe

Professor

  • 19418 Citations
  • 70 h-Index
1972 …2021
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Research Output 1972 2019

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Article
2019

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long-Term Alcohol Abstinence

Hartmann, M. C., Holbrook, S. E., Haney, M. M., Crabbe, J. J. & Rosenwasser, A. M., Jan 1 2019, In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Alcohol Abstinence
Calcium Carbonate
Alcohols
Detoxification
Air

Ethanol conditioned taste aversion in high drinking in the dark mice

Crabbe, J. J., Metten, P., Savarese, A. M., Ozburn, A., Schlumbohm, J. P., Spence, S. E. & Hack, W. R., Jan 1 2019, In : Brain Sciences. 9, 1, 2.

Research output: Contribution to journalArticle

Drinking
Ethanol
Thirst
Motivation
Injections

Genotype Differences in Sensitivity to the Anticonvulsant Effect of the Synthetic Neurosteroid Ganaxolone during Chronic Ethanol Withdrawal

Nipper, M. A., Jensen, J. P., Helms, M. L., Ford, M., Crabbe, J. J., Rossi, D. J. & Finn, D. D., Jan 15 2019, In : Neuroscience. 397, p. 127-137 11 p.

Research output: Contribution to journalArticle

Anticonvulsants
Pregnanolone
Neurotransmitter Agents
Seizures
Ethanol
2018
2 Citations (Scopus)

An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice

Metten, P., Schlumbohm, J. P., Huang, L. C., Greenberg, G. D., Hack, W. R., Spence, S. E. & Crabbe, J. J., May 1 2018, In : Alcohol. 68, p. 19-35 17 p.

Research output: Contribution to journalArticle

test battery
Behavioral Symptoms
withdrawal
alcohol
Alcohols
2 Citations (Scopus)

Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach

Ferguson, L. B., Zhang, L., Kircher, D., Wang, S., Mayfield, R. D., Crabbe, J. J., Morrisett, R. A., Harris, R. A. & Ponomarev, I., Jan 1 2018, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Binge Drinking
Genomics
Alcohol Drinking
Gene Regulatory Networks
Brain

Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs

Iancu, O., Colville, A. M., Wilmot, B., Searles, R., Darakjian, P., Zheng, C., McWeeney, S., Kawane, S., Crabbe, J. J., Metten, P., Oberbeck, D. & Hitzemann, R., Aug 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 8, p. 1454-1465 12 p.

Research output: Contribution to journalArticle

Untranslated RNA
Drinking
Genes
Gene Expression
Transcriptome
5 Citations (Scopus)

Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice

Ferguson, L. B., Ozburn, A., Ponomarev, I., Metten, P., Reilly, M., Crabbe, J. J., Harris, R. A. & Mayfield, R. D., May 1 2018, In : Neuropsychopharmacology. 43, 6, p. 1257-1266 10 p.

Research output: Contribution to journalArticle

Binge Drinking
Transcriptome
Genome
Alcohols
Drug Discovery
2 Citations (Scopus)

Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice

Purohit, K., Parekh, P. K., Kern, J., Logan, R. W., Liu, Z., Huang, Y., McClung, C. A., Crabbe, J. J. & Ozburn, A., May 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 5, p. 879-888 10 p.

Research output: Contribution to journalArticle

Clozapine
Pharmacogenetics
Nucleus Accumbens
Alcohol Drinking
Oxides

Stable histone methylation changes at proteoglycan network genes following ethanol exposure

Gavin, D. P., Hashimoto, J. G., Lazar, N. H., Carbone, L., Crabbe, J. J. & Guizzetti, M., Aug 30 2018, In : Frontiers in Genetics. 9, AUG, 346.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Proteoglycans
Histones
Methylation
Ethanol
6 Citations (Scopus)
Substance-Related Disorders
Animals
Alcohols
Recovery
Research
2017
1 Citation (Scopus)

Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID)

Hitzemann, R., Oberbeck, D., Iancu, O., Darakjian, P., McWeeney, S., Spence, S., Schlumbohm, J., Metten, P. & Crabbe, J. J., May 1 2017, In : Alcohol. 60

Research output: Contribution to journalArticle

Transcriptome
Drinking
Animals
Ethanol
animal
5 Citations (Scopus)

Ethanol withdrawal-induced dysregulation of neurosteroid levels in plasma, cortex, and hippocampus in genetic animal models of high and low withdrawal

Jensen, J. P., Nipper, M. A., Helms, M. L., Ford, M., Crabbe, J. J., Rossi, D. J. & Finn, D. D., Jun 29 2017, (Accepted/In press) In : Psychopharmacology. p. 1-19 19 p.

Research output: Contribution to journalArticle

Genetic Models
Neurotransmitter Agents
Hippocampus
Seizures
Ethanol
7 Citations (Scopus)

High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking

Crabbe, J. J., Ozburn, A., Metten, P., Barkley-Levenson, A., Schlumbohm, J. P., Spence, S. E., Hack, W. R. & Huang, L. C., Sep 1 2017, In : Pharmacology Biochemistry and Behavior. 160, p. 55-62 8 p.

Research output: Contribution to journalArticle

Binge Drinking
Drinking
Naltrexone
Alcohols
Pharmaceutical Preparations
5 Citations (Scopus)

Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence

Hashimoto, J. G., Gavin, D. P., Wiren, K., Crabbe, J. J. & Guizzetti, M., May 1 2017, In : Alcohol. 60, p. 83-94 12 p.

Research output: Contribution to journalArticle

Modifier Genes
seizure
Prefrontal Cortex
withdrawal
Chromatin
2016
1 Citation (Scopus)

Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity

Greenberg, G. D., Phillips, T. & Crabbe, J. J., Oct 15 2016, In : Physiology and Behavior. 165, p. 257-266 10 p.

Research output: Contribution to journalArticle

Ethanol
Alcohols
Seizures
Alcohol
Mouse
4 Citations (Scopus)

Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking

Crabbe, J. J., Schlumbohm, J. P., Hack, W., Barkley-Levenson, A. M., Metten, P. & Lattal, K. M., May 1 2016, In : Alcohol. 52, p. 25-32 8 p.

Research output: Contribution to journalArticle

conditioning
Freezing
Drinking
Fear
Ethanol
3 Citations (Scopus)

Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents

Greenberg, G. D. & Crabbe, J. J., 2016, (Accepted/In press) In : International Review of Neurobiology.

Research output: Contribution to journalArticle

Gene Targeting
Rodentia
Ethanol
Alcohols
Phenotype
14 Citations (Scopus)

Nest building is a novel method for indexing severity of alcohol withdrawal in mice

Greenberg, G. D., Huang, L. C., Spence, S. E., Schlumbohm, J. P., Metten, P., Ozburn, A. & Crabbe, J. J., Apr 1 2016, In : Behavioural Brain Research. 302, p. 182-190 9 p.

Research output: Contribution to journalArticle

Alcohols
Body Temperature
Inhalation
Sex Characteristics
Research Design
3 Citations (Scopus)

Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication

Barkley-Levenson, A. M., Ryabinin, A. & Crabbe, J. J., Apr 1 2016, In : Behavioural Brain Research. 302, p. 160-170 11 p.

Research output: Contribution to journalArticle

Neuropeptide Y
Nucleus Accumbens
Drinking
Alcohols
Alcohol Drinking
6 Citations (Scopus)

Progress with nonhuman animal models of addiction

Crabbe, J. J., Sep 1 2016, In : Journal of Studies on Alcohol and Drugs. 77, 5, p. 696-699 4 p.

Research output: Contribution to journalArticle

addiction
Animals
Animal Models
animal
Genetic Models
22 Citations (Scopus)

Protein kinase C epsilon activity in the nucleus accumbens and central nucleus of the amygdala mediates binge alcohol consumption

Cozzoli, D. K., Courson, J., Rostock, C., Campbell, R. R., Wroten, M. G., McGregor, H., Caruana, A. L., Miller, B. W., Hu, J. H., Zhang, P. W., Xiao, B., Worley, P. F., Crabbe, J. J., Finn, D. D. & Szumlinski, K. K., Mar 15 2016, In : Biological Psychiatry. 79, 6, p. 443-451 9 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Binge Drinking
Nucleus Accumbens
Alcohol Drinking
Alcohols
2015
13 Citations (Scopus)
Alcoholism
Alcohols
Pharmaceutical Preparations
Substance-Related Disorders
Behavioral Genetics
3 Citations (Scopus)

Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication

Barkley-Levenson, A. M. & Crabbe, J. J., Jun 1 2015, In : Genes, Brain and Behavior. 14, 5, p. 398-410 13 p.

Research output: Contribution to journalArticle

Drinking
Ethanol
Saccharin
8 Citations (Scopus)

Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice

Barkley-Levenson, A. M. & Crabbe, J. J., Feb 1 2015, In : Alcohol. 49, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

Sex Characteristics
Drinking
Anxiety
alcohol
Alcohols
13 Citations (Scopus)

Rewarding and aversive effects of ethanol in High Drinking in the Dark selectively bred mice

Barkley-Levenson, A. M., Cunningham, C., Smitasin, P. J. & Crabbe, J. J., Jan 1 2015, In : Addiction Biology. 20, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

Drinking
Ethanol
Alcohols
Lithium Chloride
Reward
2014
39 Citations (Scopus)

"Drinking in the dark" (DID): A simple mouse model of binge-like alcohol intake

Thiele, T. E., Crabbe, J. J. & Boehm, S. L., 2014, In : Current Protocols in Neuroscience. SUPP.68, 9.49.

Research output: Contribution to journalArticle

Drinking
Ethanol
Alcohols
Animal Models
Neurobiology
17 Citations (Scopus)

Dual-Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects

Metten, P., Iancu, O., Spence, S. E., Walter, N. A. R., Oberbeck, D., Harrington, C. C., Colville, A., McWeeney, S., Phillips, T., Buck, K., Crabbe, J. J., Belknap, J. & Hitzemann, R., Dec 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 12, p. 2915-2924 10 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Quantitative Trait Loci
Chromosomes
Ethanol
Genes
18 Citations (Scopus)

Experimenter effects on behavioral test scores of eight inbred mouse strains under the influence of ethanol

Bohlen, M., Hayes, E. R., Bohlen, B., Bailoo, J. D., Crabbe, J. J. & Wahlsten, D., Oct 1 2014, In : Behavioural Brain Research. 272, p. 46-54 9 p.

Research output: Contribution to journalArticle

Inbred Strains Mice
Ethanol
Injections
Odorants
Behavior Rating Scale
6 Citations (Scopus)

Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice

Fritz, B. M., Cordero, K. A., Barkley-Levenson, A. M., Metten, P., Crabbe, J. J. & Boehm, S. L., 2014, In : Alcoholism: Clinical and Experimental Research. 38, 5, p. 1284-1292 9 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Alcohols
Blood
Ataxia
Righting Reflex
18 Citations (Scopus)

High Drinking in the Dark Mice: A genetic model of drinking to intoxication

Barkley-Levenson, A. M. & Crabbe, J. J., 2014, In : Alcohol. 48, 3, p. 217-223 7 p.

Research output: Contribution to journalArticle

intoxication
Genetic Models
Drinking
Binge Drinking
Alcohols
10 Citations (Scopus)

Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics

Bubier, J. A., Jay, J. J., Baker, C. L., Bergeson, S. E., Ohno, H., Metten, P., Crabbe, J. J. & Chesler, E. J., 2014, In : Genetics. 197, 4, p. 1377-1393 17 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Genomics
Alcohols
Genes
Genetic Loci
21 Citations (Scopus)

Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice

Crabbe, J. J., Metten, P., Belknap, J., Spence, S. E., Cameron, A. J., Schlumbohm, J. P., Huang, L. C., Barkley-Levenson, A. M., Ford, M. & Phillips, T., Feb 2014, In : Genes, Brain and Behavior. 13, 2, p. 236-246 11 p.

Research output: Contribution to journalArticle

Drinking
Ethanol
Behavioral Genetics
Alcohols
Phenotype
13 Citations (Scopus)

Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal

Snelling, C., Tanchuck-Nipper, M. A., Ford, M., Jensen, J. P., Cozzoli, D. K., Ramaker, M. J., Helms, M., Crabbe, J. J., Rossi, D. J. & Finn, D. D., Sep 1 2014, In : Psychopharmacology. 231, 17, p. 3401-3414 14 p.

Research output: Contribution to journalArticle

Seizures
Ethanol
Steroids
Pregnanolone
Gas Chromatography-Mass Spectrometry
7 Citations (Scopus)

Rodent models of genetic contributions to motivation to abuse alcohol

Crabbe, J. J., 2014, In : Nebraska Symposium on Motivation. 61, p. 5-29 25 p.

Research output: Contribution to journalArticle

Animal Disease Models
Animal Behavior
Genetic Models
Genetic Predisposition to Disease
Alcoholism
1 Citation (Scopus)

Rodent models of genetic contributions to motivation to abuse alcohol

Crabbe, J. J., 2014, In : Nebraska Symposium on Motivation. 61, p. 5-29 25 p.

Research output: Contribution to journalArticle

Genetic Models
Alcoholism
Motivation
Rodentia
7 Citations (Scopus)
Gene Expression
14 Citations (Scopus)

Use of animal models of alcohol-related behavior

Crabbe, J. J., 2014, In : Handbook of Clinical Neurology. 125, p. 71-86 16 p.

Research output: Contribution to journalArticle

Animal Models
Alcohols
Genetic Models
Alcoholism
Individuality
2013

Drinking through the pain

Kash, T. L. & Crabbe, J. J., Aug 2013, In : Nature Neuroscience. 16, 8, p. 987-988 2 p.

Research output: Contribution to journalArticle

Nerve Tissue Proteins
Alcohol Deterrents
Avoidance Learning
Quinine
Nucleus Accumbens
35 Citations (Scopus)

Escalation of intake under intermittent ethanol access in diverse mouse genotypes

Rosenwasser, A. M., Fixaris, M. C., Crabbe, J. J., Brooks, P. C. & Ascheid, S., May 2013, In : Addiction Biology. 18, 3, p. 496-507 12 p.

Research output: Contribution to journalArticle

Ethanol
Genotype
Drinking
Seizures
Binge Drinking
5 Citations (Scopus)

Ethanol drinking in Withdrawal Seizure-Prone and -Resistant selected mouse lines

Crabbe, J. J., Spence, S. E., Huang, L. C., Cameron, A. J., Schlumbohm, J. P., Barkley-Levenson, A. M. & Metten, P., Aug 2013, In : Alcohol. 47, 5, p. 381-389 9 p.

Research output: Contribution to journalArticle

seizure
withdrawal
Drinking
Seizures
Ethanol
7 Citations (Scopus)

Local Changes in Neurosteroid Levels in the Substantia Nigra Reticulata and the Ventral Tegmental Area Alter Chronic Ethanol Withdrawal Severity in Male Withdrawal Seizure-Prone Mice

Tanchuck, M. A., Cozzoli, D. K., He, I., Kaufman, K. R., Snelling, C., Crabbe, J. J., Mark, G. & Finn, D. D., May 2013, In : Alcoholism: Clinical and Experimental Research. 37, 5, p. 784-793 10 p.

Research output: Contribution to journalArticle

Pregnanolone
Ventral Tegmental Area
Neurotransmitter Agents
Finasteride
Seizures
12 Citations (Scopus)

Modeling the diagnostic criteria for alcohol dependence with genetic animal models.

Crabbe, J. J., Kendler, K. S. & Hitzemann, R., 2013, In : Current Topics in Behavioral Neurosciences. 13, p. 187-221 35 p.

Research output: Contribution to journalArticle

Genetic Models
Alcoholism
Animal Models
Rodentia
Alcohols
45 Citations (Scopus)

Selection for drinking in the dark alters brain gene coexpression networks

Iancu, O., Oberbeck, D., Darakjian, P., Metten, P., McWeeney, S., Crabbe, J. J. & Hitzemann, R., Aug 2013, In : Alcoholism: Clinical and Experimental Research. 37, 8, p. 1295-1303 9 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Drinking
Brain
Genes
Phenotype
13 Citations (Scopus)

Selective breeding for ethanol-related traits alters circadian phenotype

McCulley, W. D., Ascheid, S., Crabbe, J. J. & Rosenwasser, A. M., May 2013, In : Alcohol. 47, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

Ethanol
withdrawal
Phenotype
seizure
regulation
2012
24 Citations (Scopus)

Ethanol Drinking Microstructure of a High Drinking in the Dark Selected Mouse Line

Barkley-Levenson, A. M. & Crabbe, J. J., Aug 2012, In : Alcoholism: Clinical and Experimental Research. 36, 8, p. 1330-1339 10 p.

Research output: Contribution to journalArticle

Drinking
Ethanol
Bottles
Microstructure
Animals
12 Citations (Scopus)

Ethanol Sensitivity in High Drinking in the Dark Selectively Bred Mice

Crabbe, J. J., Kruse, L. C., Colville, A. M., Cameron, A. J., Spence, S. E., Schlumbohm, J. P., Huang, L. C. & Metten, P., Jul 2012, In : Alcoholism: Clinical and Experimental Research. 36, 7, p. 1162-1170 9 p.

Research output: Contribution to journalArticle

Drinking
Ethanol
Blood
Hypothermia
Metabolism
21 Citations (Scopus)

Ethanol Tolerance and Withdrawal Severity in High Drinking in the Dark Selectively Bred Mice

Crabbe, J. J., Colville, A. M., Kruse, L. C., Cameron, A. J., Spence, S. E., Schlumbohm, J. P., Huang, L. C. & Metten, P., Jul 2012, In : Alcoholism: Clinical and Experimental Research. 36, 7, p. 1152-1161 10 p.

Research output: Contribution to journalArticle

Drinking
Ethanol
Blood
Hypothermia
Drug therapy
16 Citations (Scopus)

Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): Implications for alcohol-induced behavioral plasticity

Ary, A. W., Cozzoli, D. K., Finn, D. D., Crabbe, J. J., Dehoff, M. H., Worley, P. F. & Szumlinski, K. K., Jun 2012, In : Alcohol. 46, 4, p. 377-387 11 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Plasticity
Ethanol
Up-Regulation
alcohol
8 Citations (Scopus)

Ethanol withdrawal-induced motor impairment in mice

Philibin, S. D., Cameron, A. J., Schlumbohm, J. P., Metten, P. & Crabbe, J. J., Mar 2012, In : Psychopharmacology. 220, 2, p. 367-378 12 p.

Research output: Contribution to journalArticle

Ethanol
Seizures
Locomotion
Fatigue
Foot
44 Citations (Scopus)

Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence

Kendler, K. S., Aggen, S. H., Prescott, C. A., Crabbe, J. J. & Neale, M. C., Dec 2012, In : Molecular Psychiatry. 17, 12, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

Diagnostic and Statistical Manual of Mental Disorders
Alcoholism
Alcohol Drinking
Alcohols
Educational Status