John Jr Crabbe

Professor

  • 19760 Citations
  • 71 h-Index
1972 …2021

Research output per year

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Research Output

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2020

Suppression of voluntary ethanol intake in mice under constant light and constant darkness

Rosenwasser, A. M., McCulley, W. D., Hartmann, M. C., Fixaris, M. C. & Crabbe, J. C., Mar 2020, In : Alcohol. 83, p. 37-46 10 p.

Research output: Contribution to journalArticle

Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice

Savarese, A. M., Ozburn, A. R., Metten, P., Schlumbohm, J. P., Hack, W. R., LeMoine, K., Hunt, H., Hausch, F., Bauder, M. & Crabbe, J. C., Jan 1 2020, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

2019

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long-Term Alcohol Abstinence

Hartmann, M. C., Holbrook, S. E., Haney, M. M., Crabbe, J. J. & Rosenwasser, A. M., Jan 1 2019, In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication

Ozburn, A. R., Metten, P., Potretzke, S., Townsley, K. G., Blednov, Y. A. & Crabbe, J. C., Jan 1 2019, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

1 Scopus citations

Ethanol conditioned taste aversion in high drinking in the dark mice

Crabbe, J. J., Metten, P., Savarese, A. M., Ozburn, A., Schlumbohm, J. P., Spence, S. E. & Hack, W. R., Jan 1 2019, In : Brain Sciences. 9, 1, 2.

Research output: Contribution to journalArticle

3 Scopus citations

Genotype Differences in Sensitivity to the Anticonvulsant Effect of the Synthetic Neurosteroid Ganaxolone during Chronic Ethanol Withdrawal

Nipper, M. A., Jensen, J. P., Helms, M. L., Ford, M. M., Crabbe, J. C., Rossi, D. J. & Finn, D. A., Jan 15 2019, In : Neuroscience. 397, p. 127-137 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
6 Scopus citations
2018

An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice

Metten, P., Schlumbohm, J. P., Huang, L. C., Greenberg, G. D., Hack, W. R., Spence, S. E. & Crabbe, J. J., May 1 2018, In : Alcohol. 68, p. 19-35 17 p.

Research output: Contribution to journalArticle

5 Scopus citations

Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach

Ferguson, L. B., Zhang, L., Kircher, D., Wang, S., Mayfield, R. D., Crabbe, J. J., Morrisett, R. A., Harris, R. A. & Ponomarev, I., Jan 1 2018, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

4 Scopus citations

Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs

Iancu, O., Colville, A. M., Wilmot, B., Searles, R., Darakjian, P., Zheng, C., McWeeney, S., Kawane, S., Crabbe, J. J., Metten, P., Oberbeck, D. & Hitzemann, R., Aug 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 8, p. 1454-1465 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice

Ferguson, L. B., Ozburn, A., Ponomarev, I., Metten, P., Reilly, M., Crabbe, J. J., Harris, R. A. & Mayfield, R. D., May 1 2018, In : Neuropsychopharmacology. 43, 6, p. 1257-1266 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice

Purohit, K., Parekh, P. K., Kern, J., Logan, R. W., Liu, Z., Huang, Y., McClung, C. A., Crabbe, J. J. & Ozburn, A., May 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 5, p. 879-888 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Stable histone methylation changes at proteoglycan network genes following ethanol exposure

Gavin, D. P., Hashimoto, J. G., Lazar, N. H., Carbone, L., Crabbe, J. J. & Guizzetti, M., Aug 30 2018, In : Frontiers in Genetics. 9, AUG, 346.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID)

Hitzemann, R., Oberbeck, D., Iancu, O., Darakjian, P., McWeeney, S., Spence, S., Schlumbohm, J., Metten, P. & Crabbe, J. J., May 1 2017, In : Alcohol. 60

Research output: Contribution to journalArticle

4 Scopus citations

Ethanol withdrawal-induced dysregulation of neurosteroid levels in plasma, cortex, and hippocampus in genetic animal models of high and low withdrawal

Jensen, J. P., Nipper, M. A., Helms, M. L., Ford, M. M., Crabbe, J. C., Rossi, D. J. & Finn, D. A., Sep 1 2017, In : Psychopharmacology. 234, 18, p. 2793-2811 19 p.

Research output: Contribution to journalArticle

7 Scopus citations

High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking

Crabbe, J. J., Ozburn, A., Metten, P., Barkley-Levenson, A., Schlumbohm, J. P., Spence, S. E., Hack, W. R. & Huang, L. C., Sep 1 2017, In : Pharmacology Biochemistry and Behavior. 160, p. 55-62 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence

Hashimoto, J. G., Gavin, D. P., Wiren, K. M., Crabbe, J. C. & Guizzetti, M., May 1 2017, In : Alcohol. 60, p. 83-94 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity

Greenberg, G. D., Phillips, T. & Crabbe, J. J., Oct 15 2016, In : Physiology and Behavior. 165, p. 257-266 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking

Crabbe, J. J., Schlumbohm, J. P., Hack, W., Barkley-Levenson, A. M., Metten, P. & Lattal, K. M., May 1 2016, In : Alcohol. 52, p. 25-32 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents

Greenberg, G. D. & Crabbe, J. J., 2016, (Accepted/In press) In : International Review of Neurobiology.

Research output: Contribution to journalArticle

3 Scopus citations

Nest building is a novel method for indexing severity of alcohol withdrawal in mice

Greenberg, G. D., Huang, L. C., Spence, S. E., Schlumbohm, J. P., Metten, P., Ozburn, A. & Crabbe, J. J., Apr 1 2016, In : Behavioural Brain Research. 302, p. 182-190 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication

Barkley-Levenson, A. M., Ryabinin, A. & Crabbe, J. J., Apr 1 2016, In : Behavioural Brain Research. 302, p. 160-170 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Progress with nonhuman animal models of addiction

Crabbe, J. J., Sep 1 2016, In : Journal of Studies on Alcohol and Drugs. 77, 5, p. 696-699 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Protein kinase C epsilon activity in the nucleus accumbens and central nucleus of the amygdala mediates binge alcohol consumption

Cozzoli, D. K., Courson, J., Rostock, C., Campbell, R. R., Wroten, M. G., McGregor, H., Caruana, A. L., Miller, B. W., Hu, J. H., Zhang, P. W., Xiao, B., Worley, P. F., Crabbe, J. C., Finn, D. A. & Szumlinski, K. K., Mar 15 2016, In : Biological Psychiatry. 79, 6, p. 443-451 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2015

Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication

Barkley-Levenson, A. M. & Crabbe, J. C., Jun 1 2015, In : Genes, Brain and Behavior. 14, 5, p. 398-410 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice

Barkley-Levenson, A. M. & Crabbe, J. C., Feb 1 2015, In : Alcohol. 49, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Rewarding and aversive effects of ethanol in High Drinking in the Dark selectively bred mice

Barkley-Levenson, A. M., Cunningham, C. L., Smitasin, P. J. & Crabbe, J. C., Jan 1 2015, In : Addiction Biology. 20, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

"Drinking in the dark" (DID): A simple mouse model of binge-like alcohol intake

Thiele, T. E., Crabbe, J. C. & Boehm, S. L., 2014, In : Current Protocols in Neuroscience. SUPP.68, 9.49.

Research output: Contribution to journalArticle

41 Scopus citations

Dual-Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects

Metten, P., Iancu, O. D., Spence, S. E., Walter, N. A. R., Oberbeck, D., Harrington, C. A., Colville, A., Mcweeney, S., Phillips, T. J., Buck, K. J., Crabbe, J. C., Belknap, J. K. & Hitzemann, R. J., Dec 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 12, p. 2915-2924 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Experimenter effects on behavioral test scores of eight inbred mouse strains under the influence of ethanol

Bohlen, M., Hayes, E. R., Bohlen, B., Bailoo, J. D., Crabbe, J. C. & Wahlsten, D., Oct 1 2014, In : Behavioural Brain Research. 272, p. 46-54 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice

Fritz, B. M., Cordero, K. A., Barkley-Levenson, A. M., Metten, P., Crabbe, J. C. & Boehm, S. L., May 2014, In : Alcoholism: Clinical and Experimental Research. 38, 5, p. 1284-1292 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics

Bubier, J. A., Jay, J. J., Baker, C. L., Bergeson, S. E., Ohno, H., Metten, P., Crabbe, J. C. & Chesler, E. J., 2014, In : Genetics. 197, 4, p. 1377-1393 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice

Crabbe, J. C., Metten, P., Belknap, J. K., Spence, S. E., Cameron, A. J., Schlumbohm, J. P., Huang, L. C., Barkley-Levenson, A. M., Ford, M. M. & Phillips, T. J., Feb 1 2014, In : Genes, Brain and Behavior. 13, 2, p. 236-246 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal

Snelling, C., Tanchuck-Nipper, M. A., Ford, M. M., Jensen, J. P., Cozzoli, D. K., Ramaker, M. J., Helms, M., Crabbe, J. C., Rossi, D. J. & Finn, D. A., Sep 2014, In : Psychopharmacology. 231, 17, p. 3401-3414 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Rodent models of genetic contributions to motivation to abuse alcohol

Crabbe, J. C., Jan 1 2014, In : Nebraska Symposium on Motivation. 61, p. 5-29 25 p.

Research output: Contribution to journalArticle

1 Scopus citations

Rodent models of genetic contributions to motivation to abuse alcohol

Crabbe, J. C., Jan 1 2014, In : Nebraska Symposium on Motivation. 61, p. 5-29 25 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Escalation of intake under intermittent ethanol access in diverse mouse genotypes

Rosenwasser, A. M., Fixaris, M. C., Crabbe, J. C., Brooks, P. C. & Ascheid, S., May 1 2013, In : Addiction Biology. 18, 3, p. 496-507 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Ethanol drinking in Withdrawal Seizure-Prone and -Resistant selected mouse lines

Crabbe, J. C., Spence, S. E., Huang, L. C., Cameron, A. J., Schlumbohm, J. P., Barkley-Levenson, A. M. & Metten, P., Aug 1 2013, In : Alcohol. 47, 5, p. 381-389 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Local Changes in Neurosteroid Levels in the Substantia Nigra Reticulata and the Ventral Tegmental Area Alter Chronic Ethanol Withdrawal Severity in Male Withdrawal Seizure-Prone Mice

Tanchuck, M. A., Cozzoli, D. K., He, I., Kaufman, K. R., Snelling, C., Crabbe, J. C., Mark, G. P. & Finn, D. A., May 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, 5, p. 784-793 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Selection for drinking in the dark alters brain gene coexpression networks

Iancu, O. D., Oberbeck, D., Darakjian, P., Metten, P., Mcweeney, S., Crabbe, J. C. & Hitzemann, R., Aug 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, 8, p. 1295-1303 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Selective breeding for ethanol-related traits alters circadian phenotype

McCulley, W. D., Ascheid, S., Crabbe, J. C. & Rosenwasser, A. M., May 1 2013, In : Alcohol. 47, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Ethanol Drinking Microstructure of a High Drinking in the Dark Selected Mouse Line

Barkley-Levenson, A. M. & Crabbe, J. C., Aug 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 8, p. 1330-1339 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Ethanol Sensitivity in High Drinking in the Dark Selectively Bred Mice

Crabbe, J. C., Kruse, L. C., Colville, A. M., Cameron, A. J., Spence, S. E., Schlumbohm, J. P., Huang, L. C. & Metten, P., Jul 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 7, p. 1162-1170 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ethanol Tolerance and Withdrawal Severity in High Drinking in the Dark Selectively Bred Mice

Crabbe, J. C., Colville, A. M., Kruse, L. C., Cameron, A. J., Spence, S. E., Schlumbohm, J. P., Huang, L. C. & Metten, P., Jul 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 7, p. 1152-1161 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): Implications for alcohol-induced behavioral plasticity

Ary, A. W., Cozzoli, D. K., Finn, D. A., Crabbe, J. C., Dehoff, M. H., Worley, P. F. & Szumlinski, K. K., Jun 1 2012, In : Alcohol. 46, 4, p. 377-387 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ethanol withdrawal-induced motor impairment in mice

Philibin, S. D., Cameron, A. J., Schlumbohm, J. P., Metten, P. & Crabbe, J. C., Mar 1 2012, In : Psychopharmacology. 220, 2, p. 367-378 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence

Kendler, K. S., Aggen, S. H., Prescott, C. A., Crabbe, J. & Neale, M. C., Dec 1 2012, In : Molecular Psychiatry. 17, 12, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Intermittent availability of ethanol does not always lead to elevated drinking in mice

Crabbe, J. C., Harkness, J. H., Spence, S. E., Huang, L. C. & Metten, P., Sep 1 2012, In : Alcohol and Alcoholism. 47, 5, p. 509-517 9 p., ags067.

Research output: Contribution to journalArticle

26 Scopus citations

Nucleus Accumbens mGluR5-Associated Signaling Regulates Binge Alcohol Drinking Under Drinking-in-the-Dark Procedures

Cozzoli, D. K., Courson, J., Caruana, A. L., Miller, B. W., Greentree, D. I., Thompson, A. B., Wroten, M. G., Zhang, P. W., Xiao, B., Hu, J. H., Klugmann, M., Metten, P., Worley, P. F., Crabbe, J. C. & Szumlinski, K. K., Sep 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 9, p. 1623-1633 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice

Gallego, X., Ruiz-Medina, J., Valverde, O., Molas, S., Robles, N., Sabrià, J., Crabbe, J. C. & Dierssen, M., May 1 2012, In : Alcohol. 46, 3, p. 205-215 11 p.

Research output: Contribution to journalArticle

21 Scopus citations