• 64653 Citations
  • 110 h-Index
1971 …2020
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Research Output 1971 2020

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Article
2020
Single-Cell Analysis
Tumor-Infiltrating Lymphocytes
Fluorescent Antibody Technique
Breast Neoplasms
Neoplasms
2019
2 Citations (Scopus)

Circulating tumor DNA dynamics using patient-customized assays are associated with outcome in neoadjuvantly treated breast cancer

Butler, T. M., Boniface, C. T., Johnson-Camacho, K., Tabatabaei, S., Melendez, D., Kelley, T., Gray, J., Corless, C. & Spellman, P., Apr 1 2019, In : Cold Spring Harbor molecular case studies. 5, 2

Research output: Contribution to journalArticle

Open Access
Chemotherapy
Tumors
Assays
Breast Neoplasms
Drug Therapy
5 Citations (Scopus)

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

Langer, E. M., Allen-Petersen, B. L., King, S. M., Kendsersky, N. D., Turnidge, M. A., Kuziel, G. M., Riggers, R., Samatham, R., Amery, T. S., Jacques, S., Sheppard, B., Korkola, J., Muschler, J., Thibault, G., Chang, Y. H., Gray, J., Presnell, S. C., Nguyen, D. G. & Sears, R., Jan 15 2019, In : Cell Reports. 26, 3, p. 608-623.e6

Research output: Contribution to journalArticle

Bioprinting
Tumors
Tissue
Phenotype
Scaffolds

PLK1 and EGFR targeted nanoparticle as a radiation sensitizer for non-small cell lung cancer

Reda, M., Ngamcherdtrakul, W., Gu, S., Bejan, D. S., Siriwon, N., Gray, J. W. & Yantasee, W., Dec 28 2019, In : Cancer Letters. 467, p. 9-18 10 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Nanoparticles
Neoplasms
1 Citation (Scopus)

Robust Cell Detection and Segmentation for Image Cytometry Reveal Th17 Cell Heterogeneity

Tsujikawa, T., Thibault, G., Azimi, V., Sivagnanam, S., Banik, G., Means, C., Kawashima, R., Clayburgh, D., Gray, J., Coussens, L. & Chang, Y. H., Jan 1 2019, In : Cytometry Part A.

Research output: Contribution to journalArticle

Image Cytometry
Th17 Cells
Papillomaviridae
Immunohistochemistry
Biomarkers

Targeting mitochondria in cancer therapy could provide a basis for the selective anticancer activity

Rozanov, D., Cheltsov, A., Nilsen, A., Boniface, C., Forquer, I., Korkola, J., Gray, J., Tyner, J., Tognon, C. E., Mills, G. & Spellman, P., Mar 1 2019, In : PloS one. 14, 3, e0205623.

Research output: Contribution to journalArticle

Open Access
Mitochondria
Assays
mitochondria
therapeutics
neoplasms
1 Citation (Scopus)

Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer

Sethunath, V., Hu, H., De Angelis, C., Veeraraghavan, J., Qin, L., Wang, N., Simon, L. M., Wang, T., Fu, X., Nardone, A., Pereira, R., Nanda, S., Griffith, O. L., Tsimelzon, A., Shaw, C., Chamness, G. C., Reis-Filho, J. S., Weigelt, B., Heiser, L. M., Hilsenbeck, S. G. & 5 others, Huang, S., Rimawi, M. F., Gray, J. W., Osborne, C. K. & Schiff, R., Nov 1 2019, In : Molecular cancer research : MCR. 17, 11, p. 2318-2330 13 p.

Research output: Contribution to journalArticle

Mevalonic Acid
Breast Neoplasms
zoledronic acid
Hydroxymethylglutaryl-CoA Reductase Inhibitors
simvastatin acid
2018
17 Citations (Scopus)

CCR5 Governs DNA damage repair and breast cancer stem cell expansion

Jiao, X., Velasco-Velazquez, M. A., Wang, M., Li, Z., Rui, H., Peck, A. R., Korkola, J., Chen, X., Xu, S., DuHadaway, J. B., Guerrero-Rodriguez, S., Addya, S., Sicoli, D., Mu, Z., Zhang, G., Stucky, A., Zhang, X., Cristofanilli, M., Fatatis, A., Gray, J. & 3 others, Zhong, J. F., Prendergast, G. C. & Pestell, R. G., Apr 1 2018, In : Cancer Research. 78, 7, p. 1657-1671 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
DNA Repair
DNA Damage
Breast Neoplasms
Epithelial Cells
21 Citations (Scopus)

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

Gast, C. E., Silk, A. D., Zarour, L., Riegler, L., Burkhart, J. G., Gustafson, K. T., Parappilly, M. S., Roh-Johnson, M., Goodman, J. R., Olson, B., Schmidt, M., Swain, J. R., Davies, P., Shasthri, V., Iizuka, S., Flynn, P., Watson, S., Korkola, J., Courtneidge, S., Fischer, J. & 8 others, Jaboin, J., Billingsley, K., Lopez, C., Burchard, J., Gray, J., Coussens, L., Sheppard, B. & Wong, M., Sep 12 2018, In : Science advances. 4, 9, eaat7828.

Research output: Contribution to journalArticle

Cell Fusion
Hybrid Cells
Survival
Neoplasms
Biomarkers
13 Citations (Scopus)

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

Risom, T., Langer, E. M., Chapman, M. P., Rantala, J., Fields, A. J., Boniface, C., Alvarez, M. J., Kendsersky, N. D., Pelz, C. R., Johnson-Camacho, K., Dobrolecki, L. E., Chin, K-Y., Aswani, A. J., Wang, N. J., Califano, A., Lewis, M. T., Tomlin, C. J., Spellman, P., Adey, A., Gray, J. & 1 others, Sears, R., Dec 1 2018, In : Nature Communications. 9, 1, 3815.

Research output: Contribution to journalArticle

plastic properties
breast
chromatin
Plasticity
drugs
Oncology
Biopsy
Genes
Tumors
Testing
3 Citations (Scopus)

Lack of acquired resistance in HER2-positive breast cancer cells after long-term HER2 siRNA nanoparticle treatment

Gu, S., Ngamcherdtrakul, W., Reda, M., Hu, Z., Gray, J. & Yantasee, W., Jun 1 2018, In : PLoS One. 13, 6, e0198141.

Research output: Contribution to journalArticle

nanoparticles
small interfering RNA
breast neoplasms
Nanoparticles
Small Interfering RNA
6 Citations (Scopus)

MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection

Rozanov, D., Rozanov, N. D., Chiotti, K. E., Reddy, A., Wilmarth, P., David, L., Cha, S. W., Woo, S., Pevzner, P., Bafna, V., Burrows, G. G., Rantala, J. K., Levin, T., Anur, P., Johnson-Camacho, K., Tabatabaei, S., Munson, D. J., Bruno, T. C., Slansky, J. E., Kappler, J. W. & 9 others, Hirano, N., Boegel, S., Fox, B. A., Egelston, C., Simons, D. L., Jimenez, G., Lee, P. P., Gray, J. & Spellman, P., Mar 30 2018, In : Journal of Proteomics. 176, p. 13-23 11 p.

Research output: Contribution to journalArticle

Cells
Breast Neoplasms
Ligands
Cell Line
Peptides
7 Citations (Scopus)

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

Watson, S. S., Dane, M., Chin, K-Y., Tatarova, Z., Liu, M., Liby, T., Thompson, W., Smith, R., Nederlof, M., Bucher, E., Kilburn, D., Whitman, M., Sudar, D., Mills, G., Heiser, L., Jonas, O., Gray, J. & Korkola, J., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Breast Neoplasms
Ligands
Cell Line
Hepatocyte Growth Factor
5 Citations (Scopus)

Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells

Cornforth, M. N., Anur, P., Wang, N., Robinson, E., Ray, F. A., Bedford, J. S., Loucas, B. D., Williams, E. S., Peto, M., Spellman, P., Kollipara, R., Kittler, R., Gray, J. & Bailey, S. M., Jul 1 2018, In : Radiation Research. 190, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Genetic Translocation
sequencing
chromosomes
Computational Biology
8 Citations (Scopus)

Simultaneous Multicolor Single-Molecule Tracking with Single-Laser Excitation via Spectral Imaging

Huang, T., Phelps, C., Wang, J., Lin, L. J., Bittel, A., Scott, Z., Jacques, S., Gibbs, S., Gray, J. & Nan, X., Jan 23 2018, In : Biophysical Journal. 114, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

Lasers
Cell Tracking
Biological Phenomena
Photons
Calibration
8 Citations (Scopus)

Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution

Cheng, J. B., Sedgewick, A. J., Finnegan, A. I., Harirchian, P., Lee, J., Kwon, S., Fassett, M. S., Golovato, J., Gray, M., Ghadially, R., Liao, W., Perez White, B. E., Mauro, T. M., Mully, T., Kim, E. A., Sbitany, H., Neuhaus, I. M., Grekin, R. C., Yu, S. S., Gray, J. & 6 others, Purdom, E., Paus, R., Vaske, C. J., Benz, S. C., Song, J. S. & Cho, R. J., Oct 23 2018, In : Cell Reports. 25, 4, p. 871-883 13 p.

Research output: Contribution to journalArticle

Epidermis
Skin
Keratinocytes
RNA Sequence Analysis
Macrophages
2017
4 Citations (Scopus)

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Rahman, M., MacNeil, S. M., Jenkins, D. F., Shrestha, G., Wyatt, S. R., McQuerry, J. A., Piccolo, S. R., Heiser, L., Gray, J., Johnson, W. E. & Bild, A. H., Apr 26 2017, In : Genome Medicine. 9, 1, 40.

Research output: Contribution to journalArticle

Growth Factor Receptors
Breast Neoplasms
Phenotype
Pharmaceutical Preparations
Growth
5 Citations (Scopus)

A fully integrated, three-dimensional fluorescence to electron microscopy correlative workflow

Lopez, C., Bouchet-Marquis, C., Arthur, C. P., McQuiston, J., Heiss, G., Thibault, G., Pullan, L., Kwon, S. & Gray, J., 2017, (Accepted/In press) In : Methods in Cell Biology.

Research output: Contribution to journalArticle

Workflow
Electron Microscopy
Fluorescence
Light
Cellular Structures
15 Citations (Scopus)

Bayesian network inference modeling identifies TRIB1 as a novel regulator of cell-cycle progression and survival in cancer cells

Gendelman, R., Xing, H., Mirzoeva, O. K., Sarde, P., Curtis, C., Feiler, H., McDonagh, P., Gray, J., Khalil, I. & Korn, W. M., 2017, In : Cancer Research. 77, 7, p. 1575-1585 11 p.

Research output: Contribution to journalArticle

Cell Survival
Cell Cycle
Cyclin D1
Transcription Factor AP-1
Cell Cycle Checkpoints
24 Citations (Scopus)

Combating subclonal evolution of resistant cancer phenotypes

Brady, S. W., McQuerry, J. A., Qiao, Y., Piccolo, S. R., Shrestha, G., Jenkins, D. F., Layer, R. M., Pedersen, B. S., Miller, R. H., Esch, A., Selitsky, S. R., Parker, J. S., Anderson, L. A., Dalley, B. K., Factor, R. E., Reddy, C. B., Boltax, J. P., Li, D. Y., Moos, P. J., Gray, J. & 8 others, Heiser, L., Buys, S. S., Cohen, A. L., Johnson, W. E., Quinlan, A. R., Marth, G., Werner, T. L. & Bild, A. H., Dec 1 2017, In : Nature Communications. 8, 1, 1231.

Research output: Contribution to journalArticle

phenotype
Chemotherapy
cancer
drugs
Phenotype
9 Citations (Scopus)

Combinatorial Microenvironments Impose a Continuum of Cellular Responses to a Single Pathway-Targeted Anti-cancer Compound

Lin, C. H., Jokela, T., Gray, J. & LaBarge, M. A., Oct 10 2017, In : Cell Reports. 21, 2, p. 533-545 13 p.

Research output: Contribution to journalArticle

Tumors
Cells
Tumor Microenvironment
Military electronic countermeasures
Neoplasms
10 Citations (Scopus)

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

Hill, S. M., Nesser, N. K., Johnson-Camacho, K., Jeffress, M., Johnson, A., Boniface, C., Spencer, S. E. F., Lu, Y., Heiser, L., Lawrence, Y., Pande, N. T., Korkola, J., Gray, J., Mills, G., Mukherjee, S. & Spellman, P., Jan 25 2017, In : Cell Systems. 4, 1, p. 73-83.e10

Research output: Contribution to journalArticle

Phosphoproteins
Protein Array Analysis
Receptor Protein-Tyrosine Kinases
Proteins
Phosphotransferases
3 Citations (Scopus)

Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

Sears, R. & Gray, J., Feb 1 2017, In : Cancer Discovery. 7, 2, p. 131-133 3 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Epigenomics
Breast Neoplasms
Neoplasm Metastasis
Proteins
22 Citations (Scopus)

HER2 reactivation through acquisition of the HER2 L755S mutation as a mechanism of acquired resistance to HER2-targeted therapy in HER2+ breast cancer

Xu, X., De Angelis, C., Burke, K. A., Nardone, A., Hu, H., Qin, L., Veeraraghavan, J., Sethunath, V., Heiser, L., Wang, N., Ng, C. K. Y., Chen, E. S., Renwick, A., Wang, T., Nanda, S., Shea, M., Mitchell, T., Rajendran, M., Waters, I., Zabransky, D. J. & 14 others, Scott, K. L., Gutierrez, C., Nagi, C., Geyer, F. C., Chamness, G. C., Park, B. H., Shaw, C. A., Hilsenbeck, S. G., Rimawi, M. F., Gray, J., Weigelt, B., Reis-Filho, J. S., Osborne, C. K. & Schiff, R., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5123-5134 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Mutation
Cell Line
Small Interfering RNA
Therapeutics
6 Citations (Scopus)

Pathway-enriched gene signature associated with 53BP1 response to PARP inhibition in triple-negative breast cancer

Hassan, S., Esch, A., Liby, T., Gray, J. & Heiser, L., Dec 1 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2892-2901 10 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Genes
DNA Damage
Biomarkers
Breast Neoplasms
4 Citations (Scopus)

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics

Hafner, M., Heiser, L., Williams, E. H., Niepel, M., Wang, N. J., Korkola, J., Gray, J. & Sorger, P. K., Nov 7 2017, In : Scientific data. 4, 170166.

Research output: Contribution to journalArticle

Breast Cancer
quantification
Quantification
Cancer
Drugs
8 Citations (Scopus)

Quantitating morphological changes in biological samples during scanning electron microscopy sample preparation with correlative super-resolution microscopy

Zhang, Y., Huang, T., Jorgens, D., Nickerson, A., Lin, L. J., Pelz, J., Gray, J., Lopez, C. & Nan, X., May 1 2017, In : PLoS One. 12, 5, e0176839.

Research output: Contribution to journalArticle

Electron Scanning Microscopy
Electron microscopy
Microscopy
microscopy
Drying
2 Citations (Scopus)

Quantitative, in situ analysis of mRNAs and proteins with subcellular resolution

Kwon, S., Chin, K-Y., Nederlof, M. & Gray, J., Dec 1 2017, In : Scientific Reports. 7, 1, 16459.

Research output: Contribution to journalArticle

Messenger RNA
Breast Neoplasms
Fluorescent Antibody Technique
Proteins
RNA
92 Citations (Scopus)

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Tsujikawa, T., Kumar, S., Borkar, R. N., Azimi, V., Thibault, G., Chang, Y. H., Balter, A., Kawashima, R., Choe, G., Sauer, D., El Rassi, E., Clayburgh, D., Kulesz-Martin, M., Lutz, E. R., Zheng, L., Jaffee, E. M., Leyshock, P., Margolin, A., Mori, M. T., Gray, J. & 2 others, Flint, P. & Coussens, L., Apr 4 2017, In : Cell Reports. 19, 1, p. 203-217 15 p.

Research output: Contribution to journalArticle

Tumors
Immunohistochemistry
Tissue
Biomarkers
Papillomaviridae
17 Citations (Scopus)

Targeted treatment of metastatic breast cancer by PLK1 siRNA delivered by an antioxidant nanoparticle platform

Morry, J., Ngamcherdtrakul, W., Gu, S., Reda, M., Castro, D. J., Sangvanich, T., Gray, J. & Yantasee, W., Apr 1 2017, In : Molecular Cancer Therapeutics. 16, 4, p. 763-772 10 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Nanoparticles
Small Interfering RNA
Antioxidants
Breast Neoplasms
67 Citations (Scopus)

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C. & 87 others, Vasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J. E., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L., Gray, J., Korkola, J., Mills, G., LaBarge, M., Feiler, H., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 1 2017, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

Cataloging
Libraries
Inborn Genetic Diseases
Molecular Imaging
Neurodegenerative Diseases
2016
122 Citations (Scopus)

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

Bruna, A., Rueda, O. M., Greenwood, W., Batra, A. S., Callari, M., Batra, R. N., Pogrebniak, K., Sandoval, J., Cassidy, J. W., Tufegdzic-Vidakovic, A., Sammut, S. J., Jones, L., Provenzano, E., Baird, R., Eirew, P., Hadfield, J., Eldridge, M., McLaren-Douglas, A., Barthorpe, A., Lightfoot, H. & 10 others, O'Connor, M. J., Gray, J., Cortes, J., Baselga, J., Marangoni, E., Welm, A. L., Aparicio, S., Serra, V., Garnett, M. J. & Caldas, C., Sep 22 2016, In : Cell. 167, 1, p. 260-274.e22

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Neoplasms
Heterografts
Cells
1 Citation (Scopus)

ARTIK-52 induces replication-dependent DNA damage and p53 activation exclusively in cells of prostate and breast cancer origin

Fleyshman, D., Cheney, P., Ströse, A., Mudambi, S., Safina, A., Commane, M., Purmal, A., Morgan, K., Wang, N. J., Gray, J., Spellman, P., Issaeva, N. & Gurova, K., Feb 1 2016, In : Cell Cycle. 15, 3, p. 455-470 16 p.

Research output: Contribution to journalArticle

Androgen Receptors
DNA Damage
Prostatic Neoplasms
Breast Neoplasms
Androgens
26 Citations (Scopus)

Characterizing the immune microenvironment in high-risk ductal carcinoma in situ of the breast

Campbell, M. J., Baehner, F., O’Meara, T., Ojukwu, E., Han, B., Mukhtar, R., Tandon, V., Endicott, M., Zhu, Z., Wong, J., Krings, G., Au, A., Gray, J. & Esserman, L., Oct 26 2016, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-12 12 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Breast
Recurrence
Proliferating Cell Nuclear Antigen
HLA-DR Antigens
9 Citations (Scopus)

Current development of targeted oligonucleotide-based cancer therapies: Perspective on HER2-positive breast cancer treatment

Ngamcherdtrakul, W., Castro, D. J., Gu, S., Morry, J., Reda, M., Gray, J. & Yantasee, W., Apr 1 2016, In : Cancer Treatment Reviews. 45, p. 19-29 11 p.

Research output: Contribution to journalArticle

Oligonucleotides
Small Interfering RNA
Breast Neoplasms
Neoplasms
Nanoparticles
36 Citations (Scopus)

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Fu, X., Jeselsohn, R., Pereira, R., Hollingsworth, E. F., Creighton, C. J., Li, F., Shea, M., Nardone, A., De Angelis, C., Heiser, L., Anur, P., Wang, N., Grasso, C. S., Spellman, P., Griffith, O. L., Tsimelzon, A., Gutierrez, C., Huang, S., Edwards, D. P., Trivedi, M. V. & 7 others, Rimawi, M. F., Lopez-Terrada, D., Hilsenbeck, S. G., Gray, J., Brown, M., Osborne, C. K. & Schiff, R., Oct 25 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 43, p. E6600-E6609

Research output: Contribution to journalArticle

Interleukin-8
Transcriptome
Estrogen Receptors
Breast Neoplasms
Hepatocyte Nuclear Factor 3-alpha
1 Citation (Scopus)

Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death

Guest, S. T., Kratche, Z. R., Irish, J. C., Wilson, R. C., Haddad, R., Gray, J., Garrett-Mayer, E. & Ethier, S. P., 2016, In : Oncotarget. 7, 24, p. 36138-36153 16 p.

Research output: Contribution to journalArticle

Oncogenes
Cell Death
Breast Neoplasms
Neoplasms
Cell Line
25 Citations (Scopus)

Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer

Seviour, E. G., Sehgal, V., Lu, Y., Luo, Z., Moss, T., Zhang, F., Hill, S. M., Liu, W., Maiti, S. N., Cooper, L., Azencot, R., Lopez-Berestein, G., Rodriguez-Aguayo, C., Roopaimoole, R., Pecot, C., Sood, A. K., Mukherjee, S., Gray, J., Mills, G. & Ram, P. T., Feb 11 2016, In : Oncogene. 35, 6, p. 691-701 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Proteomics
Ovarian Neoplasms
Breast Neoplasms
Neoplasms
5 Citations (Scopus)

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Hu, Z., Mao, J. H., Curtis, C., Huang, G., Gu, S., Heiser, L., Lenburg, M. E., Korkola, J., Bayani, N., Samarajiwa, S., Seoane, J. A., Dane, M., Esch, A., Feiler, H., Wang, N. J., Hardwicke, M. A., Laquerre, S., Jackson, J., Wood, K., Weber, B. & 5 others, Spellman, P., Aparicio, S., Wooster, R., Caldas, C. & Gray, J., Jul 1 2016, In : Breast Cancer Research. 18, 1, 70.

Research output: Contribution to journalArticle

Spindle Apparatus
Gene Regulatory Networks
Up-Regulation
Genome
Breast Neoplasms
22 Citations (Scopus)

IL-10 and integrin signaling pathways are associated with head and neck cancer progression

Bornstein, S., Schmidt, M., Choonoo, G., Levin, T., Gray, J., Thomas, C., Wong, M. & McWeeney, S., Jan 8 2016, In : BMC Genomics. 17, 1, 38.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Integrins
Interleukin-10
Genes
Neoplasms
83 Citations (Scopus)

Inferring causal molecular networks: Empirical assessment through a community-based effort

Hill, S. M., Heiser, L., Cokelaer, T., Unger, M., Nesser, N. K., Carlin, D. E., Zhang, Y., Sokolov, A., Paull, E. O., Wong, C. K., Graim, K., Bivol, A., Wang, H., Zhu, F., Afsari, B., Danilova, L. V., Favorov, A. V., Lee, W. S., Taylor, D., Hu, C. W. & 18 others, Long, B. L., Noren, D. P., Bisberg, A. J., Mills, G., Gray, J., Kellen, M., Norman, T., Friend, S., Qutub, A. A., Fertig, E. J., Guan, Y., Song, M., Stuart, J. M., Spellman, P., Koeppl, H., Stolovitzky, G., Saez-Rodriguez, J. & Mukherjee, S., Mar 30 2016, In : Nature Methods. 13, 4, p. 310-318 9 p.

Research output: Contribution to journalArticle

Phosphoproteins
Learning
Nonlinear Dynamics
Computer Simulation
Visualization
3 Citations (Scopus)

Multiplexed imaging reveals heterogeneity of PI3K/MAPK network signaling in breast lesions of known PIK3CA genotype

Jacob, T., Gray, J., Troxell, M. & Vu, T. T., Oct 1 2016, In : Breast Cancer Research and Treatment. 159, 3, p. 575-583 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Breast
Genotype
Phosphoproteins
Hyperplasia
4 Citations (Scopus)

PI3 Kinase Pathway Mutations in Human Cancers

Gray, J., Dec 1 2016, In : JAMA oncology. 2, 12, p. 1543-1544 2 p.

Research output: Contribution to journalArticle

Morpholines
Isoquinolines
Quinazolinones
Aminopyridines
PTEN Phosphohydrolase

Reconstruction of Gene Regulatory Networks Based on Repairing Sparse Low-Rank Matrices

Chang, Y. H., Dobbe, R., Bhushan, P., Gray, J. & Tomlin, C. J., Jul 1 2016, In : IEEE/ACM Transactions on Computational Biology and Bioinformatics. 13, 4, p. 767-777 11 p., 7182286.

Research output: Contribution to journalArticle

Low-rank Matrices
Gene Regulatory Networks
Gene Regulatory Network
Sparse matrix
Genes
15 Citations (Scopus)

The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment

Turpin, J., Ling, C., Crosby, E. J., Hartman, Z. C., Simond, A. M., Chodosh, L. A., Rennhack, J. P., Andrechek, E. R., Ozcelik, J., Hallett, M., Mills, G., Cardiff, R. D., Gray, J., Griffith, O. L. & Muller, W. J., May 9 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Tumor Microenvironment
Breast Neoplasms
Proto-Oncogenes
Keratins
Neoplasms
13 Citations (Scopus)

Therapeutic siRNA for drug-resistant HER2-positive breast cancer

Gu, S., Hu, Z., Ngamcherdtrakul, W., Castro, D. J., Morry, J., Reda, M. M., Gray, J. & Yantasee, W., Mar 22 2016, In : Oncotarget. 7, 12, p. 14727-14741 15 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Breast Neoplasms
Pharmaceutical Preparations
Cell Line
Neoplasms
68 Citations (Scopus)

Tumor-derived cell lines as molecular models of cancer pharmacogenomics

Goodspeed, A., Heiser, L., Gray, J. & Costello, J. C., Jan 1 2016, In : Molecular Cancer Research. 14, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Molecular Models
Pharmacogenetics
Tumor Cell Line
Neoplasms
Cell Line
2015
88 Citations (Scopus)

Cationic polymer modified mesoporous silica nanoparticles for targeted siRNA delivery to HER2+ breast cancer

Ngamcherdtrakul, W., Morry, J., Gu, S., Castro, D. J., Goodyear, S. M., Sangvanich, T., Reda, M. M., Lee, R., Mihelic, S. A., Beckman, B. L., Hu, Z., Gray, J. & Yantasee, W., May 13 2015, In : Advanced Functional Materials. 25, 18, p. 2646-2659 14 p.

Research output: Contribution to journalArticle

breast
Silicon Dioxide
Small Interfering RNA
delivery
Polymers
10 Citations (Scopus)

Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer

Korkola, J., Collisson, E. A., Heiser, L., Oates, C., Bayani, N., Itani, S., Esch, A., Thompson, W., Griffith, O. L., Wang, N. J., Kuo, W. L., Cooper, B., Billig, J., Ziyad, S., Hung, J. L., Feiler, H., Lu, Y., Mills, G., Spellman, P., Tomlin, C. & 3 others, Mukherjee, S., Gray, J. & Jakkula, L., Jul 16 2015, In : PLoS One. 10, 7, e0133219.

Research output: Contribution to journalArticle

phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
breast neoplasms
Breast Neoplasms
mutation