• 67302 Citations
  • 113 h-Index
1971 …2020

Research output per year

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Research Output

2000

Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene

Albertson, D. G., Ylstra, B., Segraves, R., Collins, C., Dairkee, S. H., Kowbel, D., Kuo, W. L., Gray, J. W. & Pinkel, D., Jun 1 2000, In : Nature genetics. 25, 2, p. 144-146 3 p.

Research output: Contribution to journalArticle

492 Scopus citations

Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5′ nuclease quantitative reverse transcription-polymerase chain reaction

Godfrey, T. E., Kim, S. H., Chavira, M., Ruff, D. W., Warren, R. S., Gray, J. W. & Jensen, R. H., May 2000, In : Journal of Molecular Diagnostics. 2, 2, p. 84-91 8 p.

Research output: Contribution to journalArticle

254 Scopus citations
1999

Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization

Korn, W. M., Yasutake, T., Kuo, W. L., Warren, R. S., Collins, C., Tomita, M., Gray, J. & Waldman, F. M., Jun 1 1999, In : Genes Chromosomes and Cancer. 25, 2, p. 82-90 9 p.

Research output: Contribution to journalArticle

116 Scopus citations

Measurement of genetic instability in breast cancer by confocal microscopy and 3D image analysis

Ortiz de Solorzano, C., Chin, K., Chou, W. S., Knowles, D., Gray, J. W. & Lockett, S. J., Dec 1 1999, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. IEEE, 1 p. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

Yu, Y., Xu, F., Peng, H., Fang, X., Zhao, S., Li, Y., Cuevas, B., Kuo, W. L., Gray, J. W., Siciliano, M., Mills, G. B. & Bast, R. C., Jan 5 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 1, p. 214-219 6 p.

Research output: Contribution to journalArticle

251 Scopus citations

PlK3CA is implicated as an oncogene in ovarian cancer

Shayesteh, L., Lu, Y., Kuo, W. L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G. B. & Gray, J. W., Jan 1 1999, In : Nature genetics. 21, 1, p. 99-102 4 p.

Research output: Contribution to journalArticle

977 Scopus citations

Segmentation of confocal microscope images of cell nuclei in thick tissue sections

Ortiz De Solórzano, C., García Rodriguez, E., Jones, A., Pinkel, D., Gray, J. W., Sudar, D. & Lockett, S. J., Apr 6 1999, In : Journal of Microscopy. 193, 3, p. 212-226 15 p.

Research output: Contribution to journalArticle

122 Scopus citations

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

Sternlicht, M. D., Lochtest, A., Sympson, C. J., Huey, B., Rougier, J. P., Gray, J. W., Pinkel, D., Bissell, M. J. & Werb, Z., Jul 23 1999, In : Cell. 98, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

710 Scopus citations
1998

Cancer-associated gene abnormalities and chemosensitivity

Sakamoto, M., Umayahara, K., Sakamoto, H., Kawasaki, K., Suehiro, Y., Kunugi, T., Akiya, T., Iwabuchi, H., Sakunaga, H., Muroya, T., Kikuchi, Y., Sugishita, T., Tenjin, Y., Gray, J. W. & Tanaka, T., Oct 1998, In : Gan to kagaku ryoho. Cancer & chemotherapy. 25, 12, p. 1819-1831 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Efficient, interactive, and three-dimensional segmentation of cell nuclei in thick tissue sections

Lockett, S. J., Sudar, D., Thompson, C. T., Pinkel, D. & Gray, J. W., Apr 1 1998, In : Cytometry. 31, 4, p. 275-286 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Genetic analysis using genomic representations

Lucito, R., Nakimura, M., West, J. A., Han, Y., Chin, K., Jensen, K., Mccombie, R., Gray, J. W. & Wigler, M., Apr 14 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 8, p. 4487-4492 6 p.

Research output: Contribution to journalArticle

61 Scopus citations

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

Pinkel, D., Segraves, R., Sudar, D., Clark, S., Poole, I., Kowbel, D., Collins, C., Kuo, W. L., Chen, C., Zhai, Y., Dairkee, S. H., Ljung, B. M., Gray, J. W. & Albertson, D. G., Oct 15 1998, In : Nature genetics. 20, 2, p. 207-211 5 p.

Research output: Contribution to journalArticle

1717 Scopus citations

Interactive system for registering adjacent tissue sections

Lockett, S. J., Fernandez, C., Rodriguez, E., Wesselmann, U., Bastian, B. C., Sudar, D., Pinkel, D. & Gray, J., Dec 1 1998, In : Proceedings of SPIE - The International Society for Optical Engineering. 3260, p. 154-161 8 p.

Research output: Contribution to journalConference article

Mechanisms of inactivation of E-cadherin in breast cancer cell lines

Hiraguri, S., Godfrey, T., Nakamura, H., Graff, J., Collins, C., Shayesteh, L., Doggett, N., Johnson, K., Wheelock, M., Herman, J., Baylin, S., Pinkel, D. & Gray, J., May 1 1998, In : Cancer Research. 58, 9, p. 1972-1977 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Molecular cytogenetic analysis of consistent abnormalities at 8q12-q22 in breast cancer

Fejzo, M. S., Godfrey, T., Chen, C., Waldman, F. & Gray, J. W., Jun 1 1998, In : Genes Chromosomes and Cancer. 22, 2, p. 105-113 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Positional cloning of ZNF217 and NABC1: Genes amplified at 20q13.2 and overexpressed in breast carcinoma

Collins, C., Rommens, J. M., Kowbel, D., Godfrey, T., Tanner, M., Hwang, S. I., Polikoff, D., Nonet, G., Cochran, J., Myambo, K., Jay, K. E., Froula, J., Cloutier, T., Kuo, W. L., Yaswen, P., Dairkee, S., Giovanola, J., Hutchinson, G. B., Isola, J., Kallioniemi, O. P. & 7 others, Palazzolo, M., Martin, C., Ericsson, C., Pinkel, D., Albertson, D., Li, W. B. & Gray, J. W., Jul 21 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 15, p. 8703-8708 6 p.

Research output: Contribution to journalArticle

262 Scopus citations

Segmentation of Cell Nuclei from Confocal Microscope Images of Thick Tissue Samples

Ortiz de Solorzano, C., Sarti, A., Rodriguez, E. G., Jones, A., Sudar, D., Pinkel, D., Gray, J. W., Malladi, R. & Lockett, S. J., Dec 1 1998, p. 187-190. 4 p.

Research output: Contribution to conferencePaper

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

Zhou, H., Kuang, J., Zhong, L., Kuo, W. L., Gray, J. W., Sahin, A., Brinkley, B. R. & Sen, S., Oct 15 1998, In : Nature genetics. 20, 2, p. 189-193 5 p.

Research output: Contribution to journalArticle

1080 Scopus citations
1997

20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16 E7 transformed human uroepithelial cells

Savelieva, E., Belair, C. D., Newton, M. A., DeVries, S., Gray, J. W., Waldman, F. & Reznikoff, C. A., Jan 1 1997, In : Oncogene. 14, 5, p. 551-560 10 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

A t-statistic for objective interpretation of comparative genomic hybridization (CGH) profiles

Moore, D. H., Pallavicini, M., Cher, M. L. & Gray, J. W., Jul 1 1997, In : Cytometry. 28, 3, p. 183-190 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

DNA copy number changes associated with characteristic LOH in islet cell carcinomas of transgenic mice

Shi, Y. P., Naik, P., Dietrich, W. F., Gray, J. W., Hanahan, D. & Pinkel, D., Jun 14 1997, In : Genes Chromosomes and Cancer. 19, 2, p. 104-111 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

ESX: A structurally unique Ets overexpressed early during human breast tumorigenesis

Chang, C. H., Scott, G. K., Kuo, W. L., Xiong, X., Suzdaltseva, Y., Park, J. W., Sayre, P., Erny, K., Collins, C., Gray, J. W. & Benz, C. C., Jan 1 1997, In : Oncogene. 14, 13, p. 1617-1622 6 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations

Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype

Barsky, S. H., Sternlicht, M. D., Safarians, S., Nguyen, M., Chin, K., Stewart, S. D., Hiti, A. L. & Gray, J. W., Jan 1 1997, In : Oncogene. 15, 17, p. 2077-2091 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

FISH probes for mouse chromosome identification

Shi, Y. P., Mohapatra, G., Miller, J., Hanahan, D., Lander, E., Gold, P., Pinkel, D. & Gray, J., Oct 1 1997, In : Genomics. 45, 1, p. 42-47 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Objective aneuploidy detection for fetal and neonatal screening using comparative genomic hybridization (CGH)

Yu, L. C., Moore, D. H., Magrane, G., Cronin, J., Pinkel, D., Lebo, R. V. & Gray, J. W., Jul 1 1997, In : Cytometry. 28, 3, p. 191-197 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s

Morton, S. M., Veile, R. A., Helms, C., Lee, M., Kuo, W. L., Gray, J. & Donis-Keller, H., Dec 15 1997, In : Genomics. 46, 3, p. 491-494 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
1996

Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)

Brzoska, P. M., Chen, H., Levin, N. A., Kuo, W. L., Collins, C., Fu, K. K., Gray, J. W. & Christman, M. F., Aug 15 1996, In : Genomics. 36, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

High sensitivity, high resolution physical mapping by fluorescence in situ hybridization on to individual straightened DNA molecules

Wang, M., Duell, T., Gray, J. W. & Weier, H. U. G., Jan 1 1996, In : Bioimaging. 4, 2, p. 73-83 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer

Tanner, M. M., Tirkkonen, M., Kallioniemi, A., Isola, J., Kuukasjärvi, T., Collins, C., Kowbel, D., Guan, X. Y., Trent, J., Gray, J. W., Meltzer, P. & Kallioniemi, O. P., Aug 1 1996, In : Cancer Research. 56, 15, p. 3441-3445 5 p.

Research output: Contribution to journalArticle

176 Scopus citations

The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.

Donehower, L. A., Godley, L. A., Aldaz, C. M., Pyle, R., Shi, Y. P., Pinkel, D., Gray, J., Bradley, A., Medina, D. & Varmus, H. E., 1996, In : Progress in clinical and biological research. 395, p. 1-11 11 p.

Research output: Contribution to journalReview article

21 Scopus citations
1995

Amplification of Chromosomal Region 20ql3 in Invasive Breast Cancer: Prognostic Implications

Tanner, M. M., Tirkkonen, M., Kallioniemi, A., Holli, K., Collins, C., Kowbel, D., Gray, J. W., Kallioniemi, O. P. & Isola, J., Aug 1 1995, In : Clinical Cancer Research. 1, 12, p. 1455-1461 7 p.

Research output: Contribution to journalArticle

127 Scopus citations

A physical map of chromosome 20 established using fluorescence in situ hybridization and digital image analysis

Stokke, T., Collins, C., Kuo, W. L., Kowbel, D., Shadravan, F., Tanner, M., Kallioniemi, A., Kallioniemi, O. P., Pinkel, D., Deaven, L. & Gray, J. W., Jan 1 1995, In : Genomics. 26, 1, p. 134-137 4 p.

Research output: Contribution to journalArticle

57 Scopus citations

Chromosomal localization of the γ-glutamyl carboxylase gene at 2p12

Kuo, W. L., Stafford, D. W., Cruces, J., Gray, J. & Jesú, S., Jan 1 1995, In : Genomics. 25, 3, p. 746-748 3 p.

Research output: Contribution to journalArticle

29 Scopus citations

Computer image analysis of comparative genomic hybridization

Piper, J., Rutovitz, D., Sudar, D., Kallioniemi, A., Kallioniemi, OP. P., Waldman, F. M., Gray, J. W. & Pinkel, D., Jan 1 1995, In : Cytometry. 19, 1, p. 10-26 17 p.

Research output: Contribution to journalArticle

235 Scopus citations

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

Donehower, L. A., Godley, L. A., Aldaz, C. M., Pyle, R., Shi, Y. P., Pinkel, D., Gray, J., Bradley, A., Medina, D. & Varmus, H. E., Apr 1 1995, In : Genes and Development. 9, 7, p. 882-895 14 p.

Research output: Contribution to journalArticle

Open Access
244 Scopus citations

Frequent Novel DNA Copy Number Increase in Squamous Cell Head and Neck Tumors

Brzoska, P. M., Levin, N. A., Fu, K. K., Kaplan, M. J., Singer, M. I., Gray, J. W. & Christman, M. F., Jul 15 1995, In : Cancer Research. 55, 14, p. 3055-3059 5 p.

Research output: Contribution to journalArticle

97 Scopus citations

Genetic Analysis of Benign, Low-Grade, and High-Grade Ovarian Tumors

Iwabuchi, H., Sakamoto, M., Sakunaga, H., Ma, Y. Y., Carcangiu, M. L., Pinkel, D., Yang-Feng, T. L. & Gray, J. W., Dec 15 1995, In : Cancer Research. 55, 24, p. 6172-6180 9 p.

Research output: Contribution to journalArticle

273 Scopus citations

Identification of novel regions of altered DNA copy number in small cell lung tumors

Levin, N. A., Bnorka, P. M., Warnock, M. L., Gray, J. W. & Christman, M. F., Jul 1995, In : Genes, Chromosomes and Cancer. 13, 3, p. 175-185 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

Interactive algorithms for rapid enumeration of hybridization signals in individual whole-cell nuclei inside intact-tissue specimens

Lockett, S. J., Thompson, C. T., Mullikin, J. C., Sudar, D., Khavari, R., Hyun, W., Pinkel, D. & Gray, J. W., Jan 1 1995, Proceedings of SPIE - The International Society for Optical Engineering. Wilson, T. & Cogswell, C. J. (eds.). Society of Photo-Optical Instrumentation Engineers, p. 43-49 7 p. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 2412).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Karyotypic heterogeneity and its relation to labeling index in interphase breast tumor cells

Balazs, M., Matsumura, K., Moore, D., Pinkel, D., Gray, J. W. & Waldman, F. M., May 1 1995, In : Cytometry. 20, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Quantitative DNA fiber mapping

Weler, H. U. G., Wang, L., Mullikin, J. C., Zhu, Y., Cheng, J. F., Greulich, K. M., Bensimon, A. & Gray, J. W., Oct 1 1995, In : Human molecular genetics. 4, 10, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

92 Scopus citations

Semiautomated DNA probe mapping using digital imaging microscopy: I. System development

Mascio, L. N., Verbeek, P. W., Sudar, D., Kuo, WL. L. & Gray, J. W., Jan 1 1995, In : Cytometry. 19, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Semiautomated DNA probe mapping using digital imaging microscopy: II. System performance

Sakamoto, M., Pinkel, D., Mascio, L., Sudar, D., Peters, D., Kuo, WL. L., Yamakawa, K., Nakamura, Y., Drabkin, H., Jericevic, Z., Smith, L. & Gray, J. W., Jan 1 1995, In : Cytometry. 19, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
1994

A mouse Chromosome 11 library generated from sorted chromosomes using linker-adapter polymerase chain reaction

Miyashita, K., Vooijs, M. A., Tucker, J. D., Lee, D. A., Gray, J. W. & Pallavicini, M. G., Jan 1 1994, In : Cytogenetic and Genome Research. 66, 1, p. 54-57 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Defining the steps in a multistep mouse model for mammary carcinogenesis

Varmus, H. E., Godley, L. A., Roy, S., Taylor, I. C. A., Yuschenkoff, L., Shi -, Y. P., Pinkel, D., Gray, J., Pyle, R., Aldaz, C. M., Bradley, A., Medina, D. & Donehower, L. A., Jan 1 1994, In : Cold Spring Harbor symposia on quantitative biology. 59, p. 491-499 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization

Kallioniemi, A., Kallioniemi, O. P., Piper, J., Tanner, M., Stokke, T., Chen, L., Smith, H. S., Pinkel, D., Gray, J. W. & Waldman, F. M., Mar 15 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 6, p. 2156-2160 5 p.

Research output: Contribution to journalArticle

Open Access
677 Scopus citations

Detection of a human chromosomal translocation t(8;9) in a baby with multiple malformations using two‐color fluorescence in situ hybridization

Sasaki, K., Pinkel, D., Tsukahara, M., Murano, I. & Gray, J. W., Feb 1994, In : Pathology International. 44, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Digital imaging microscopy for molecular cytogenetics

Gray, J., Lockett, S., Mascio, L., Mullikin, J., Pinkel, D., Piper, J., Sudar, D. & Thompson, C., Dec 1 1994, p. 82-83. 2 p.

Research output: Contribution to conferencePaper

1 Scopus citations

Fluorescence in situ hybridization in cancer and radiation biology

Gray, J. W., Pinkel, D. & Brown, J. M., Jan 1 1994, In : Radiation research. 137, 3, p. 275-289 15 p.

Research output: Contribution to journalReview article

56 Scopus citations

Generation of five high-complexity painting probe libraries from flow-sorted mouse chromosomes

Weier, H. U. G., Polikoff, D., Fawcett, J. J., Greulich, K. M., Lee, K. H., Cram, S., Chapman, V. M. & Gray, J. W., Jun 1994, In : Genomics. 21, 3, p. 641-644 4 p.

Research output: Contribution to journalArticle

55 Scopus citations