• 66579 Citations
  • 112 h-Index
1971 …2020

Research output per year

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Research Output

2006

EGFR intron 1 polymorphism in Asian populations and its correlation with EGFR gene expression and amplification in breast tumor tissues

Zhou, Q., Yin, B. C., Jada, S. R., Wan, T. L., Kuo, W. L., Gray, J. W., Lee, A. S. G. & Chowbay, B., Nov 2006, In : Cancer Biology and Therapy. 5, 11, p. 1445-1449 5 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

Chin, K., DeVries, S., Fridlyand, J., Spellman, P. T., Roydasgupta, R., Kuo, W. L., Lapuk, A., Neve, R. M., Qian, Z., Ryder, T., Chen, F., Feiler, H., Tokuyasu, T., Kingsley, C., Dairkee, S., Meng, Z., Chew, K., Pinkel, D., Jain, A., Ljung, B. M. & 4 others, Esserman, L., Albertson, D. G., Waldman, F. M. & Gray, J. W., Dec 1 2006, In : Cancer Cell. 10, 6, p. 529-541 13 p.

Research output: Contribution to journalArticle

921 Scopus citations

Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel

Bussey, K. J., Chin, K., Lababidi, S., Reimers, M., Reinhold, W. C., Kuo, W. L., Gwadry, F., Ajay, Kouros-Mehr, H., Fridlyand, J., Jain, A., Collins, C., Nishizuka, S., Tonon, G., Roschke, A., Gehlhaus, K., Kirsch, I., Scudiero, D. A., Gray, J. W. & Weinstein, J. N., Apr 1 2006, In : Molecular cancer therapeutics. 5, 4, p. 853-867 15 p.

Research output: Contribution to journalArticle

127 Scopus citations

Magellan: A web based system for the integrated analysis of heterogeneous biological data and annotations; application to DNA copy number and expression data in ovarian cancer

Kingsley, C. B., Kuo, W. L., Polikoff, D., Berchuck, A., Gray, J. W. & Jain, A. N., Jun 15 2006, In : Cancer Informatics. 2, p. 10-21 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Organic cation transporters are determinants of oxaliplatin cytotoxicity

Zhang, S., Lovejoy, K. S., Shima, J. E., Lagpacan, L. L., Shu, Y., Lapuk, A., Chen, Y., Komori, T., Gray, J. W., Chen, X., Lippard, S. J. & Giacomini, K. M., Sep 1 2006, In : Cancer Research. 66, 17, p. 8847-8857 11 p.

Research output: Contribution to journalArticle

275 Scopus citations

Prognostic value of PAI1 in invasive breast cancer: Evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression

Sternlicht, M. D., Dunning, A. M., Moore, D. H., Pharoah, P. D. P., Ginzinger, D. G., Chin, K., Gray, J. W., Waldman, F. M., Ponder, B. A. J. & Werb, Z., Nov 1 2006, In : Cancer Epidemiology Biomarkers and Prevention. 15, 11, p. 2107-2114 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Qdot nanobarcodes for multiplexed gene expression analysis

Eastman, P. S., Ruan, W., Doctolero, M., Nuttall, R., De Feo, G., Park, J. S., Chu, J. S. F., Cooke, P., Gray, J. W., Li, S. & Chen, F. F., May 1 2006, In : Nano Letters. 6, 5, p. 1059-1064 6 p.

Research output: Contribution to journalArticle

146 Scopus citations

β1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

Park, C. C., Zhang, H., Pallavicini, M., Gray, J. W., Baehner, F., Park, C. J. & Bissell, M. J., Feb 1 2006, In : Cancer Research. 66, 3, p. 1526-1535 10 p.

Research output: Contribution to journalArticle

242 Scopus citations
2007

Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers.

Yau, C., Fedele, V., Roydasgupta, R., Fridlyand, J., Hubbard, A., Gray, J. W., Chew, K., Dairkee, S. H., Moore, D. H., Schittulli, F., Tommasi, S., Paradiso, A., Albertson, D. G. & Benz, C. C., 2007, In : Breast cancer research : BCR. 9, 5, p. R59

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer

Nanjundan, M., Nakayama, Y., Kwai, W. C., Lahad, J., Liu, J., Lu, K., Kuo, W. L., Smith-McCune, K., Fishman, D., Gray, J. W. & Mills, G. B., Apr 1 2007, In : Cancer Research. 67, 7, p. 3074-3084 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer

Guan, Y., Kuo, W. L., Stilwell, J. L., Takano, H., Lapuk, A. V., Fridlyand, J., Mao, J. H., Yu, M., Miller, M. A., Santos, J. L., Kalloger, S. E., Carlson, J. W., Ginzinger, D. G., Celniker, S. E., Mills, G. B., Huntsman, D. G. & Gray, J. W., Oct 1 2007, In : Clinical Cancer Research. 13, 19, p. 5745-5755 11 p.

Research output: Contribution to journalArticle

265 Scopus citations

Analysis of molecular inversion probe performance for allele copy number determination

Wang, Y., Moorhead, M., Karlin-Neumann, G., Wang, N. J., Ireland, J., Lin, S., Chen, C., Heiser, L. M., Chin, K., Esserman, L., Gray, J. W., Spellman, P. T. & Faham, M., Nov 20 2007, In : Genome biology. 8, 11, R246.

Research output: Contribution to journalArticle

50 Scopus citations

Assessing human germ-cell mutagenesis in the postgenome era: A celebration of the legacy of William Lawson (Bill) Russell

Wyrobek, A. J., Mulvihill, J. J., Wassom, J. S., Malling, H. V., Shelby, M. D., Lewis, S. E., Witt, K. L., Preston, R. J., Perreault, S. D., Allen, J. W., DeMarini, D. M., Woychik, R. P., Bishop, J. B., Anderson, D., Arnheim, N., Boice, J. D., Bridges, B. A., Crow, J. F., Dubrova, Y. E., Eichenlaub-Ritter, U. & 16 others, Erickson, R. P., Fridlyand, J., Gray, J., Hanawalt, P. C., Handel, M. A., Marchetti, F., Mohrenweiser, H. W., Moyzis, R. K., Primig, M., Russell, L. B., Sankaranarayanan, K., Skinner, M. K., Shoubridge, E. A., Taylor, J. A., Trasler, J. M. & Vasicek, T. J., Feb 1 2007, In : Environmental and Molecular Mutagenesis. 48, 2, p. 71-95 25 p.

Research output: Contribution to journalArticle

47 Scopus citations

Crosstalk between Aurora-A and p53: Frequent Deletion or Downregulation of Aurora-A in Tumors from p53 Null Mice

Mao, J. H., Wu, D., Perez-Losada, J., Jiang, T., Li, Q., Neve, R. M., Gray, J. W., Cai, W. W. & Balmain, A., Feb 13 2007, In : Cancer Cell. 11, 2, p. 161-173 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer

Climent, J., Dimitrow, P., Fridlyand, J., Palacios, J., Siebert, R., Albertson, D. G., Gray, J. W., Pinkel, D., Lluch, A. & Martinez-Climent, J. A., Jan 15 2007, In : Cancer Research. 67, 2, p. 818-826 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

Zhou, Y., Yau, C., Gray, J. W., Chew, K., Dairkee, S. H., Moore, D. H., Eppenberger, U., Eppenberger-Castori, S. & Benz, C. C., Apr 25 2007, In : BMC cancer. 7, 59.

Research output: Contribution to journalArticle

139 Scopus citations

Gamma-normal-gamma mixture model for detecting differentially methylated loci in three breast cancer cell lines

Khalili, A., Potter, D., Yan, P., Li, L., Gray, J., Huang, T. & Lin, S., Jul 23 2007, In : Cancer Informatics. 3, p. 43-54 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Multiple roles of the candidate oncogene ZNF217 in ovarian epithelial neoplastic progression

Li, P., Maines-Bandiera, S., Kuo, W. L., Guan, Y., Sun, Y., Hills, M., Huang, G., Collins, C. C., Leung, P. C. K., Gray, J. W. & Auersperg, N., May 1 2007, In : International Journal of Cancer. 120, 9, p. 1863-1873 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Nanobarcode gene expression monitoring system for potential miniaturized space applications

Ruan, W., Eastman, P. S., Cooke, P. A., Park, J. S., Chu, J. S. F., Gray, J. W., Li, S. & Chen, F. F., Jan 1 2007, In : Advances in Space Research. 40, 4, p. 513-522 10 p.

Research output: Contribution to journalArticle

Paramagnetic silica-coated nangcrystals as an advanced MRI contrast agent

Gerion, D., Herberg, J., Bok, R., Gjersing, E., Ramon, E., Maxwell, R., Kurhanewicz, J., Budinger, T. F., Gray, J. W., Shuman, M. A. & Chen, F. F., Aug 30 2007, In : Journal of Physical Chemistry C. 111, 34, p. 12542-12551 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Spectral decomposition of signaling networks

Parvin, B., Ghosh, N., Heiser, L., Knapp, M., Talcott, C., Laderoute, K., Gray, J. & Spellman, P., Dec 1 2007, 2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology, CIBCB 2007. p. 76-81 6 p. 4221207. (2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology, CIBCB 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Systems biology in cancer research: genomics to cellomics.

Stilwell, J. L., Guan, Y., Neve, R. M. & Gray, J. W., 2007, In : Methods in molecular biology (Clifton, N.J.). 356, p. 353-365 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression

Kenny, P. A., Lee, G. Y., Myers, C. A., Neve, R. M., Semeiks, J. R., Spellman, P. T., Lorenz, K., Lee, E. H., Barcellos-Hoff, M. H., Petersen, O. W., Gray, J. W. & Bissell, M. J., Jun 1 2007, In : Molecular Oncology. 1, 1, p. 84-96 13 p.

Research output: Contribution to journalArticle

606 Scopus citations
2008

A human breast cell model of preinvasive to invasive transition

Rizki, A., Weaver, V. M., Lee, S. Y., Rozenberg, G. I., Chin, K., Myers, C. A., Bascom, J. L., Mott, J. D., Semeiks, J. R., Grate, L. R., Mian, I. S., Borowsky, A. D., Jensen, R. A., Idowu, M. O., Chen, F., Chen, D. J., Petersen, O. W., Gray, J. W. & Bissell, M. J., Mar 1 2008, In : Cancer Research. 68, 5, p. 1378-1387 10 p.

Research output: Contribution to journalArticle

106 Scopus citations

Amplification of 11q13 in ovarian carcinoma

Brown, L. A., Kalloger, S. E., Miller, M. A., Shih, L. M., McKinney, S. E., Santos, J. L., Swenerton, K., Spellman, P. T., Gray, J., Gilks, C. B. & Huntsman, D. G., Jun 1 2008, In : Genes Chromosomes and Cancer. 47, 6, p. 481-489 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

Stemke-Hale, K., Gonzalez-Angulo, A. M., Lluch, A., Neve, R. M., Kuo, W. L., Davies, M., Carey, M., Hu, Z., Guan, Y., Sahin, A., Symmans, W. F., Pusztai, L., Nolden, L. K., Horlings, H., Berns, K., Hung, M. C., Van De Vijver, M. J., Valero, V., Gray, J. W., Bernards, R. & 2 others, Mills, G. B. & Hennessy, B. T., Aug 1 2008, In : Cancer Research. 68, 15, p. 6084-6091 8 p.

Research output: Contribution to journalArticle

665 Scopus citations

A sequence-based survey of the complex structural organization of tumor genomes

Raphael, B. J., Volik, S., Yu, P., Wu, C., Huang, G., Linardopoulou, E. V., Trask, B. J., Waldman, F., Costello, J., Pienta, K. J., Mills, G. B., Bajsarowicz, K., Kobayashi, Y., Sridharan, S., Paris, P. L., Tao, Q., Aerni, S. J., Brown, R. P., Bashir, A., Gray, J. W. & 6 others, Cheng, J. F., de Jong, P., Nefedov, M., Ried, T., Padilla-Nash, H. M. & Collins, C. C., Mar 25 2008, In : Genome biology. 9, 3, R59.

Research output: Contribution to journalArticle

31 Scopus citations

Cancer Genomics

Spellman, P. T., Costello, J. F. & Gray, J. W., Dec 1 2008, The Molecular Basis of Cancer. Elsevier Inc., p. 267-282 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

McLendon, R., Friedman, A., Bigner, D., Van Meir, E. G., Brat, D. J., Mastrogianakis, G. M., Olson, J. J., Mikkelsen, T., Lehman, N., Aldape, K., Yung, W. K. A., Bogler, O., Weinstein, J. N., VandenBerg, S., Berger, M., Prados, M., Muzny, D., Morgan, M., Scherer, S., Sabo, A. & 211 others, Nazareth, L., Lewis, L., Hall, O., Zhu, Y., Ren, Y., Alvi, O., Yao, J., Hawes, A., Jhangiani, S., Fowler, G., San Lucas, A., Kovar, C., Cree, A., Dinh, H., Santibanez, J., Joshi, V., Gonzalez-Garay, M. L., Miller, C. A., Milosavljevic, A., Donehower, L., Wheeler, D. A., Gibbs, R. A., Cibulskis, K., Sougnez, C., Fennell, T., Mahan, S., Wilkinson, J., Ziaugra, L., Onofrio, R., Bloom, T., Nicol, R., Ardlie, K., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., McLellan, M. D., Wallis, J., Larson, D. E., Shi, X., Abbott, R., Fulton, L., Chen, K., Koboldt, D. C., Wendl, M. C., Meyer, R., Tang, Y., Lin, L., Osborne, J. R., Dunford-Shore, B. H., Miner, T. L., Delehaunty, K., Markovic, C., Swift, G., Courtney, W., Pohl, C., Abbott, S., Hawkins, A., Leong, S., Haipek, C., Schmidt, H., Wiechert, M., Vickery, T., Scott, S., Dooling, D. J., Chinwalla, A., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Getz, G., Winckler, W., Verhaak, R. G. W., Lawrence, M. S., O'Kelly, M., Robinson, J., Alexe, G., Beroukhim, R., Carter, S., Chiang, D., Gould, J., Gupta, S., Korn, J., Mermel, C., Mesirov, J., Monti, S., Nguyen, H., Parkin, M., Reich, M., Stransky, N., Weir, B. A., Garraway, L., Golub, T., Meyerson, M., Chin, L., Protopopov, A., Zhang, J., Perna, I., Aronson, S., Sathiamoorthy, N., Ren, G., Yao, J., Wiedemeyer, W. R., Kim, H., Sek, W. K., Xiao, Y., Kohane, I. S., Seidman, J., Park, P. J., Kucherlapati, R., Laird, P. W., Cope, L., Herman, J. G., Weisenberger, D. J., Pan, F., Van Den Berg, D., Van Neste, L., Joo, M. Y., Schuebel, K. E., Baylin, S. B., Absher, D. M., Li, J. Z., Southwick, A., Brady, S., Aggarwal, A., Chung, T., Sherlock, G., Brooks, J. D., Myers, R. M., Spellman, P. T., Purdom, E., Jakkula, L. R., Lapuk, A. V., Marr, H., Dorton, S., Yoon, G. C., Han, J., Ray, A., Wang, V., Durinck, S., Robinson, M., Wang, N. J., Vranizan, K., Peng, V., Van Name, E., Fontenay, G. V., Ngai, J., Conboy, J. G., Parvin, B., Feiler, H. S., Speed, T. P., Gray, J. W., Brennan, C., Socci, N. D., Olshen, A., Taylor, B. S., Lash, A., Schultz, N., Reva, B., Antipin, Y., Stukalov, A., Gross, B., Cerami, E., Wei, Q. W., Qin, L. X., Seshan, V. E., Villafania, L., Cavatore, M., Borsu, L., Viale, A., Gerald, W., Sander, C., Ladanyi, M., Perou, C. M., Hayes, D. N., Topal, M. D., Hoadley, K. A., Qi, Y., Balu, S., Shi, Y., Wu, J., Penny, R., Bittner, M., Shelton, T., Lenkiewicz, E., Morris, S., Beasley, D., Sanders, S., Kahn, A., Sfeir, R., Chen, J., Nassau, D., Feng, L., Hickey, E., Barker, A., Gerhard, D. S., Vockley, J., Compton, C., Vaught, J., Fielding, P., Ferguson, M. L., Schaefer, C., Zhang, J., Madhavan, S., Buetow, K. H., Collins, F., Good, P., Guyer, M., Ozenberger, B., Peterson, J. & Thomson, E., Oct 23 2008, In : Nature. 455, 7216, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

4641 Scopus citations

Dicer, Drosha, and outcomes in patients with ovarian cancer

Merritt, W. M., Lin, Y. G., Han, L. Y., Kamat, A. A., Spannuth, W. A., Schmandt, R., Urbauer, D., Pennacchio, L. A., Cheng, J. F., Nick, A. M., Deavers, M. T., Mourad-Zeidan, A., Wang, H., Mueller, P., Lenburg, M. E., Gray, J. W., Mok, S., Birrer, M. J., Lopez-Berestein, G., Coleman, R. L. & 2 others, Bar-Eli, M. & Sood, A. K., Dec 18 2008, In : New England Journal of Medicine. 359, 25, p. 2641-2650 10 p.

Research output: Contribution to journalArticle

528 Scopus citations

ESR1 gene amplification in breast cancer: A common phenomenon? [1]

Brown, L. A., Hoog, J., Chin, S. F., Tao, Y., Zayed, A. A., Chin, K., Teschendorff, A. E., Quackenbush, J. F., Marioni, J. C., Leung, S., Perou, C. M., Neilsen, T. O., Ellis, M., Gray, J. W., Bernard, P. S., Huntsman, D. G. & Caldas, C., Jul 1 2008, In : Nature genetics. 40, 7, p. 806-807 2 p.

Research output: Contribution to journalLetter

48 Scopus citations

Ovarian cancer: Linking genomics to new target discovery and molecular markers - The way ahead

Hennessy, B. T., Murph, M., Nanjundan, M., Carey, M., Auersperg, N., Almeida, J., Coombes, K. R., Liu, J., Lu, Y., Gray, J. W. & Mills, G. B., Dec 1 2008, Hormonal Carcinogenesis V. Li, J., Li, S., Mohla, S., Rochefort, H., Rochefort, H. & Maudelonde, T. (eds.). p. 23-40 18 p. (Advances in Experimental Medicine and Biology; vol. 617).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

Press, J. Z., De Luca, A., Boyd, N., Young, S., Troussard, A., Ridge, Y., Kaurah, P., Kalloger, S. E., Blood, K. A., Smith, M., Spellman, P. T., Wang, Y., Miller, D. M., Horsman, D., Faham, M., Gilks, C. B., Gray, J. & Huntsman, D. G., Jan 22 2008, In : BMC cancer. 8, 17.

Research output: Contribution to journalArticle

222 Scopus citations

Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis

Nanjundan, M., Cheng, K. W., Zhang, F., Lahad, J., Kuo, W. L., Schmandt, R., Smith-McCune, K., Fishman, D., Gray, J. W. & Mills, G. B., Aug 1 2008, In : Molecular Oncology. 2, 2, p. 164-181 18 p.

Research output: Contribution to journalArticle

22 Scopus citations

Preface

Mendelsohn, J., Howley, P. M., Israel, M. A., Gray, J. W. & Thompson, C. B., Dec 1 2008, The Molecular Basis of Cancer. Elsevier Inc., p. xv-xvi

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

1 Scopus citations

Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

Tutt, A., Wang, A., Rowland, C., Gillett, C., Lau, K., Chew, K., Dai, H., Kwok, S., Ryder, K., Shu, H., Springall, R., Cane, P., McCallie, B., Kam-Morgan, L., Anderson, S., Buerger, H., Gray, J., Bennington, J., Esserman, L., Hastie, T. & 4 others, Broder, S., Sninsky, J., Brandt, B. & Waldman, F., Nov 21 2008, In : BMC cancer. 8, 339.

Research output: Contribution to journalArticle

42 Scopus citations

The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

Sun, Y., Wong, N., Guan, Y., Salamanca, C. M., Jung, C. C., Lee, J. M., Gray, J. W. & Auersperg, N., Oct 15 2008, In : International Journal of Cancer. 123, 8, p. 1761-1769 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

The Molecular Basis of Cancer

Mendelsohn, J., Howley, P. M., Israel, M. A., Gray, J. & Thompson, C. B., 2008, Elsevier Inc.

Research output: Book/ReportBook

28 Scopus citations

Translating insights from the cancer genome into clinical practice

Chin, L. & Gray, J. W., Apr 3 2008, In : Nature. 452, 7187, p. 553-563 11 p.

Research output: Contribution to journalReview article

215 Scopus citations

Translational Research Working Group developmental pathway for biospecimen-based assessment modalities

Srivastava, S., Gray, J. W., Reid, B. J., Grad, O., Greenwood, A. & Hawk, E. T., Sep 15 2008, In : Clinical Cancer Research. 14, 18, p. 5672-5677 6 p.

Research output: Contribution to journalReview article

25 Scopus citations
2009

A primer on regression methods for decoding cis-regulatory logic

Das, D., Pellegrini, M. & Gray, J. W., Jan 1 2009, In : PLoS computational biology. 5, 1, e1000269.

Research output: Contribution to journalArticle

13 Scopus citations

A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047

Kuo, W. L., Das, D., Ziyad, S., Bhattacharya, S., Gibb, W. J., Heiser, L. M., Sadanandam, A., Fontenay, G. V., Hu, Z., Wang, N. J., Bayani, N., Feiler, H. S., Neve, R. M., Wyrobek, A. J., Spellman, P. T., Marton, L. J. & Gray, J. W., Dec 14 2009, In : BMC Medicine. 7, 77.

Research output: Contribution to journalArticle

24 Scopus citations

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

Mirzoeva, O. K., Das, D., Heiser, L. M., Bhattacharya, S., Siwak, D., Gendelman, R., Bayani, N., Wang, N. J., Neve, R. M., Guan, Y., Hu, Z., Knight, Z., Feiler, H. S., Gascard, P., Parvin, B., Spellman, P. T., Shokat, K. M., Wyrobek, A. J., Bissell, M. J., McCormick, F. & 4 others, Kuo, W. L., Mills, G. B., Gray, J. W. & Korn, W. M., Jan 15 2009, In : Cancer Research. 69, 2, p. 565-572 8 p.

Research output: Contribution to journalArticle

271 Scopus citations

Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

Hennessy, B. T., Gonzalez-Angulo, A. M., Stemke-Hale, K., Gilcrease, M. Z., Krishnamurthy, S., Lee, J. S., Fridlyand, J., Sahin, A., Agarwal, R., Joy, C., Liu, W., Stivers, D., Baggerly, K., Carey, M., Lluch, A., Monteagudo, C., He, X., Weigman, V., Fan, C., Palazzo, J. & 7 others, Hortobagyi, G. N., Nolden, L. K., Wang, N. J., Valero, V., Gray, J. W., Perou, C. M. & Mills, G. B., May 15 2009, In : Cancer Research. 69, 10, p. 4116-4124 9 p.

Research output: Contribution to journalArticle

583 Scopus citations

Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts

Hodgson, J. G., Yeh, R. F., Ray, A., Wang, N. J., Smirnov, I., Yu, M., Hariono, S., Silber, J., Feiler, H. S., Gray, J. W., Spellman, P. T., Vandenberg, S. R., Berger, M. S. & James, C. D., Oct 1 2009, In : Neuro-Oncology. 11, 5, p. 477-487 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays

Wang, Y., Carlton, V. E., Karlin-Neumann, G., Sapolsky, R., Zhang, L., Moorhead, M., Wang, Z. C., Richardson, A. L., Warren, R., Walther, A., Bondy, M., Sahin, A., Krahe, R., Tuna, M., Thompson, P. A., Spellman, P. T., Gray, J. W., Mills, G. B. & Faham, M., Apr 6 2009, In : BMC Medical Genomics. 2, 8.

Research output: Contribution to journalArticle

74 Scopus citations

Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells

Dairkee, S. H., Sayeed, A., Luciani, G., Champion, S., Zhenhang, M., Jakkula, L. R., Feiler, H. S., Gray, J. W. & Moore, D. H., Oct 1 2009, In : Cancer Research. 69, 19, p. 7826-7834 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

Heiser, L. M., Wang, N. J., Talcott, C. L., Laderoute, K. R., Knapp, M., Guan, Y., Hu, Z., Ziyad, S., Weber, B. L., Laquerre, S., Jackson, J. R., Wooster, R. F., Kuo, W., Gray, J. W. & Spellman, P. T., Mar 25 2009, In : Genome biology. 10, 3, R31.

Research output: Contribution to journalArticle

51 Scopus citations

Integrative analysis of cyclin protein levels identifies cyclin B1 as a classifier and predictor of outcomes in breast cancer

Agarwal, R., Gonzalez-Angulo, A. M., Myhre, S., Carey, M., Lee, J. S., Overgaard, J., Alsner, J., Stemke-Hale, K., Lluch, A., Neve, R. M., Kuo, W. L., Sorlie, T., Sahin, A., Valero, V., Keyomarsi, K., Gray, J. W., Borresen-Dale, A. L., Mills, G. B. & Hennessy, B. T., Jun 1 2009, In : Clinical Cancer Research. 15, 11, p. 3654-3662 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer

Ong, D. C. T., Ho, Y. M., Rudduck, C., Chin, K., Kuo, W. L., Lie, D. K. H., Chua, C. L. M., Tan, P. H., Eu, K. W., Seow-Choen, F., Wong, C. Y., Hong, G. S., Gray, J. W. & Lee, A. S. G., Nov 1 2009, In : Oncogene. 28, 47, p. 4189-4200 12 p.

Research output: Contribution to journalArticle

17 Scopus citations