Jens Kreth

Associate Professor

  • 1875 Citations
  • 24 h-Index
19992019
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Research Output 1999 2019

  • 1875 Citations
  • 24 h-Index
  • 68 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins

Hall, J. W., Lima, B. P., Herbomel, G. G., Gopinath, T., McDonald, L. A., Shyne, M. T., Lee, J. K., Kreth, J., Ross, K. F., Veglia, G. & Herzberg, M. C., May 7 2019, In : Science signaling. 12, 580

Research output: Contribution to journalArticle

Biofilms
Bacteria
Cell membranes
Networks (circuits)
Processing

At the Interface of Materials and Microbiology: A Call for the Development of Standardized Approaches to Assay Biomaterial-Biofilm Interactions

Kreth, J., Ferracane, J. L., Pfeifer, C. S., Khajotia, S. & Merritt, J., Jul 1 2019, In : Journal of dental research. 98, 8, p. 850-852 3 p.

Research output: Contribution to journalArticle

Materials Testing
Streptococcus mutans
Composite Resins
Biocompatible Materials
Biofilms

Examining the Protein Interactome and Subcellular Localization of RNase J2 Complexes in Streptococcus mutans

Mu, R., Shinde, P., Zou, Z., Kreth, J. & Merritt, J., Sep 18 2019, In : Frontiers in Microbiology. 10, 2150.

Research output: Contribution to journalArticle

Open Access
Streptococcus mutans
Ribonucleases
Proteins
Escherichia coli
Enzymes

Genetics of sanguinis-Group Streptococci in Health and Disease

Nobbs, A. & Kreth, J., Jan 1 2019, In : Microbiology spectrum. 7, 1

Research output: Contribution to journalArticle

health and disease
Streptococcus
biofilm
microbial community
commensal
1 Citation (Scopus)

Genome-wide screening of potential RNase Y-processed mRNAs in the M49 serotype Streptococcus pyogenes NZ131

Chen, Z., Raghavan, R., Qi, F., Merritt, J. & Kreth, J., Apr 1 2019, In : MicrobiologyOpen. 8, 4, e00671.

Research output: Contribution to journalArticle

Open Access
Streptococcus pyogenes
Ribonucleases
Genome
Messenger RNA
Streptococcus
2018
4 Citations (Scopus)

Distinct regulatory role of carbon catabolite protein A (CcpA) in oral streptococcal spxB expression

Redanz, S., Masilamani, R., Cullin, N., Giacaman, R. A., Merritt, J. & Kreth, J., Apr 1 2018, In : Journal of Bacteriology. 200, 8, e00619-17.

Research output: Contribution to journalArticle

Staphylococcal Protein A
Carbon
Streptococcus gordonii
Carbohydrates
Streptococcus
4 Citations (Scopus)

In silico analysis of the competition between Streptococcus sanguinis and Streptococcus mutans in the dental biofilm

Valdebenito, B., Tullume-Vergara, P. O., González, W., Kreth, J. & Giacaman, R. A., Jan 1 2018, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

Streptococcus mutans
Biofilms
Streptococcus
Computer Simulation
Tooth
5 Citations (Scopus)

Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome

Redanz, S., Cheng, X., Giacaman, R. A., Pfeifer, C., Merritt, J. & Kreth, J., Jan 1 2018, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

lactate 2-monooxygenase
Microbiota
Hydrogen Peroxide
Pyruvate Oxidase
Oral Health

LytTR Regulatory Systems: A potential new class of prokaryotic sensory system

Zou, Z., Qin, H., Brenner, A. E., Raghavan, R., Millar, J. A., Gu, Q., Xie, Z., Kreth, J. & Merritt, J., Oct 1 2018, In : PLoS Genetics. 14, 10, p. e1007709

Research output: Contribution to journalArticle

sensory system
operon
Operon
protein
Streptococcus mutans
6 Citations (Scopus)

Plasticity of the pyruvate node modulates hydrogen peroxide production and acid tolerance in multiple oral streptococci

Cheng, X., Redanz, S., Cullin, N., Zhou, X., Xu, X., Joshi, V., Koley, D., Merritt, J. & Kreth, J., Jan 1 2018, In : Applied and Environmental Microbiology. 84, 2, e01697-17.

Research output: Contribution to journalArticle

acid tolerance
Streptococcus gordonii
Streptococcus
Pyruvic Acid
hydrogen peroxide
1 Citation (Scopus)

Streptococcus mutans and Streptococcus sanguinis Expression of Competition-Related Genes, under Sucrose

Lozano, C. P., DÍaz-Garrido, N., Kreth, J. & Giacaman, R. A., Jan 1 2018, (Accepted/In press) In : Caries Research. p. 194-203 10 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Streptococcus
Sucrose
Biofilms
Dental Enamel
2017
2 Citations (Scopus)

Identification of new degrons in Streptococcus mutans reveals a novel strategy for engineering targeted, controllable proteolysis

Liu, N., Chaudhry, M. T., Xie, Z., Kreth, J. & Merritt, J., Dec 19 2017, In : Frontiers in Microbiology. 8, DEC, 2572.

Research output: Contribution to journalArticle

Streptococcus mutans
Proteolysis
Poisons
Proteins
Peptide Hydrolases
2 Citations (Scopus)

Interference of a speB 5′ untranslated region partial deletion with mRNA degradation in Streptococcus pyogenes

Chen, Z., Mashburn-Warren, L., Merritt, J., Federle, M. J. & Kreth, J., 2017, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

5' Untranslated Regions
Streptococcus pyogenes
RNA Stability
Messenger RNA
Ribonucleases
1 Citation (Scopus)

Murein hydrolase LytF of Streptococcus sanguinis and the ecological consequences of competence development

Cullin, N., Redanz, S., Lampi, K., Merritt, J. & Kreth, J., Dec 1 2017, In : Applied and Environmental Microbiology. 83, 24, e01709-17.

Research output: Contribution to journalArticle

Streptococcus sanguinis
N-Acetylmuramoyl-L-alanine Amidase
peptidoglycans
Biofilms
hydrolases
5 Citations (Scopus)
Veillonella
Microbiota
Mental Competency
Veillonellaceae
Aptitude
10 Citations (Scopus)

Pt-Decorated MWCNTs-Ionic Liquid Composite-Based Hydrogen Peroxide Sensor to Study Microbial Metabolism Using Scanning Electrochemical Microscopy

Joshi, V. S., Kreth, J. & Koley, D., Jul 18 2017, In : Analytical Chemistry. 89, 14, p. 7709-7718 10 p.

Research output: Contribution to journalArticle

Ionic Liquids
Metabolism
Hydrogen Peroxide
Microscopic examination
Scanning
8 Citations (Scopus)

Real-Time Metabolic Interactions between Two Bacterial Species Using a Carbon-Based pH Microsensor as a Scanning Electrochemical Microscopy Probe

Joshi, V. S., Sheet, P. S., Cullin, N., Kreth, J. & Koley, D., Oct 17 2017, In : Analytical Chemistry. 89, 20, p. 11044-11052 9 p.

Research output: Contribution to journalArticle

Microsensors
Lactic Acid
Microscopic examination
Carbon
Scanning
5 Citations (Scopus)
Streptococcus mutans
Nucleic Acid Repetitive Sequences
Mutagenesis
Organism Cloning
Fenclonine
2016
1 Citation (Scopus)

Effect of salivary agglutination on oral streptococcal clearance by human polymorphonuclear neutrophil granulocytes

Itzek, A., Chen, Z., Merritt, J. & Kreth, J., 2016, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

Agglutination
Phagocytosis
Granulocytes
Neutrophils
Streptococcus gordonii
10 Citations (Scopus)
bioluminescence
Biofilms
Luciferases
biofilm
mouth
6 Citations (Scopus)

Real-time assessment of Streptococcus mutans biofilm metabolism on resin composite

Esteban Florez, F. L., Hiers, R. D., Smart, K., Kreth, J., Qi, F., Merritt, J. & Khajotia, S. S., Oct 1 2016, In : Dental Materials. 32, 10, p. 1263-1269 7 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Composite Resins
Biofilms
Metabolism
Bioluminescence
20 Citations (Scopus)

The road less traveled - defining molecular commensalism with Streptococcus sanguinis

Kreth, J., Giacaman, R. A., Raghavan, R. & Merritt, J., 2016, (Accepted/In press) In : Molecular Oral Microbiology.

Research output: Contribution to journalArticle

Symbiosis
Oral Health
Streptococcus
Mouth Diseases
Stomatognathic Diseases
2015
22 Citations (Scopus)

Correlation of Streptococcus mutans and Streptococcus sanguinis colonization and ex vivo hydrogen peroxide production in carious lesion-free and high caries adults

Giacaman, R. A., Torres, S., Gómez, Y., Muñoz-Sandoval, C. & Kreth, J., Jan 1 2015, In : Archives of Oral Biology. 60, 1, p. 154-159 6 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Streptococcus
Hydrogen Peroxide
Saliva
Agar
1 Citation (Scopus)

RNA regulators of host immunity and pathogen adaptive responses in the oral cavity

Kreth, J., Liu, N., Chen, Z. & Merritt, J., Jul 1 2015, In : Microbes and Infection. 17, 7, p. 493-504 12 p.

Research output: Contribution to journalArticle

Adaptive Immunity
Mouth
RNA
Explosions
22 Citations (Scopus)

The Streptococcus mutans irvA Gene Encodes a trans-Acting Riboregulatory mRNA

Liu, N., Niu, G., Xie, Z., Chen, Z., Itzek, A., Kreth, J., Gillaspy, A., Zeng, L., Burne, R., Qi, F. & Merritt, J., Jan 8 2015, In : Molecular Cell. 57, 1, p. 179-190 12 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Messenger RNA
Genes
5' Untranslated Regions
RNA Stability
2014
13 Citations (Scopus)

Comparison of genes required for H2O2 resistance in Streptococcus gordonii and Streptococcus sanguinis

Xu, Y., Itzek, A. & Kreth, J., Dec 1 2014, In : Microbiology (Reading, England). 160, p. 2627-2638 12 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
Streptococcus
Biofilms
Genes
Pyruvate Oxidase
12 Citations (Scopus)

Probing oral microbial functionality - Expression of spxB in plaque samples

Zhu, L., Xu, Y., Ferretti, J. J. & Kreth, J., Jan 29 2014, In : PLoS One. 9, 1, e86685.

Research output: Contribution to journalArticle

Metagenome
mouth
Biofilms
Genes
Microbiota
2013
18 Citations (Scopus)

Characterization of Pyruvate Uptake in Escherichia coli K-12

Kreth, J., Lengeler, J. W. & Jahreis, K., Jun 20 2013, In : PLoS One. 8, 6, e67125.

Research output: Contribution to journalArticle

Escherichia coli K12
Pyruvic Acid
Escherichia coli
excretion
uptake mechanisms
16 Citations (Scopus)

Multiple roles of rnase y in streptococcus pyogenes mrna processing and degradation

Chen, Z., Itzek, A., Malke, H., Ferretti, J. J. & Kreth, J., Jun 1 2013, In : Journal of Bacteriology. 195, 11, p. 2585-2594 10 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Ribonucleases
RNA Stability
Messenger RNA
Exoribonucleases
7 Citations (Scopus)

Role of LytF and AtlS in eDNA Release by Streptococcus gordonii

Xu, Y. & Kreth, J., Apr 24 2013, In : PLoS One. 8, 4, e62339.

Research output: Contribution to journalArticle

Streptococcus gordonii
DNA
Pyruvate Oxidase
N-Acetylmuramoyl-L-alanine Amidase
Mental Competency
2012
22 Citations (Scopus)

CcpA regulates biofilm formation and competence in Streptococcus gordonii

Zheng, L., Chen, Z., Itzek, A., Herzberg, M. C. & Kreth, J., Apr 1 2012, In : Molecular Oral Microbiology. 27, 2, p. 83-94 12 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
Biofilms
Mental Competency
Streptococcus
Catabolite Repression
16 Citations (Scopus)

Dynamics of speB mRNA transcripts in streptococcus pyogenes

Chen, Z., Itzek, A., Malke, H., Ferretti, J. J. & Kreth, J., Mar 1 2012, In : Journal of Bacteriology. 194, 6, p. 1417-1426 10 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
RNA Stability
Messenger RNA
Streptococcus
Growth
10 Citations (Scopus)

Oligomerization of the response regulator come from streptococcus mutans is affected by phosphorylation

Hung, D. C. I., Downey, J. S., Kreth, J., Qi, F., Shi, W., Cvitkovitch, D. G. & Goodman, S. D., Mar 1 2012, In : Journal of Bacteriology. 194, 5, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Phosphorylation
Deoxyribonuclease I
DNA
Electrophoretic Mobility Shift Assay
2011
39 Citations (Scopus)

Catabolite control protein a controls hydrogen peroxide production and cell death in streptococcus sanguinis

Zheng, L., Chen, Z., Itzek, A., Ashby, M. & Kreth, J., Jan 1 2011, In : Journal of Bacteriology. 193, 2, p. 516-526 11 p.

Research output: Contribution to journalArticle

Staphylococcal Protein A
Streptococcus
Hydrogen Peroxide
Cell Death
Pyruvate Oxidase
12 Citations (Scopus)

Characterization of competence and biofilm development of a Streptococcus sanguinis endocarditis isolate

Zhu, L., Zhang, Y., Fan, J., Herzberg, M. C. & Kreth, J., Apr 1 2011, In : Molecular Oral Microbiology. 26, 2, p. 117-126 10 p.

Research output: Contribution to journalArticle

Biofilms
Endocarditis
Streptococcus
Mental Competency
Genes
32 Citations (Scopus)

Characterization of DNA binding sites of the ComE response regulator from Streptococcus mutans

Hung, D. C. I., Downey, J. S., Ayala, E. A., Kreth, J., Mair, R., Senadheera, D. B., Qi, F., Cvitkovitch, D. G., Shi, W. & Goodman, S. D., Jul 1 2011, In : Journal of Bacteriology. 193, 14, p. 3642-3652 11 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Nucleic Acid Repetitive Sequences
Binding Sites
Deoxyribonuclease I
DNA
27 Citations (Scopus)

Counteractive balancing of transcriptome expression involving CodY and CovRS in Streptococcus pyogenes

Kreth, J., Chen, Z., Ferretti, J. & Malke, H., Aug 1 2011, In : Journal of Bacteriology. 193, 16, p. 4153-4165 13 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Streptococcus
Transcriptome
NAD+ Nucleosidase
Fimbriae Proteins
30 Citations (Scopus)

Environmental influences on competitive hydrogen peroxide production in Streptococcus gordonii

Zheng, L., Itzek, A., Chen, Z. & Kreth, J., Jul 1 2011, In : Applied and Environmental Microbiology. 77, 13, p. 4318-4328 11 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
hydrogen peroxide
Hydrogen Peroxide
carbohydrate
oral health
27 Citations (Scopus)

Hydrogen peroxide-dependent DNA release and transfer of antibiotic resistance genes in Streptococcus gordonii

Itzek, A., Zheng, L., Chen, Z., Merritt, J. & Kreth, J., Dec 2011, In : Journal of Bacteriology. 193, 24, p. 6912-6922 11 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
Microbial Drug Resistance
Hydrogen Peroxide
DNA
Genes
10 Citations (Scopus)

Mechanism of adhesion maintenance by methionine sulphoxide reductase in Streptococcus gordonii

Lei, Y., Zhang, Y., Guenther, B. D., Kreth, J. & Herzberg, M. C., May 1 2011, In : Molecular Microbiology. 80, 3, p. 726-738 13 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
Biofilms
Maintenance
Methionine
Cell Wall
8 Citations (Scopus)

Microbicidal efficacy of thiocyanate hydrogen peroxide after adding lactoperoxidase under saliva loading in the quantitative suspension test

Welk, A., Rudolph, P., Kreth, J., Schwahn, C., Kramer, A. & Below, H., Dec 1 2011, In : Archives of Oral Biology. 56, 12, p. 1576-1582 7 p.

Research output: Contribution to journalArticle

Lactoperoxidase
Saliva
Hydrogen Peroxide
Suspensions
Streptococcus mutans
24 Citations (Scopus)

Oxygen dependent pyruvate oxidase expression and production in Streptococcus sanguinis

Zheng, L. Y., Itzek, A., Chen, Z. Y. & Kreth, J., Apr 1 2011, In : International journal of oral science. 3, 2, p. 82-89 8 p.

Research output: Contribution to journalArticle

Pyruvate Oxidase
Streptococcus mutans
Streptococcus
Oxygen
Proteins
2010
4 Citations (Scopus)

Characterization of anti-competitor activities produced by oral bacteria.

Qi, F. & Kreth, J., Dec 1 2010, In : Methods in molecular biology (Clifton, N.J.). 666, p. 151-166 16 p.

Research output: Contribution to journalArticle

Bacteriocins
Dental Caries
Bacteria
Streptococcus mutans
Deciduous Tooth
7 Citations (Scopus)
Streptococcus mutans
Protein-Serine-Threonine Kinases
Streptococcus
Bacteriocins
Metrorrhagia
38 Citations (Scopus)

Systematic approach to optimizing specifically targeted antimicrobial peptides against Streptococcus mutans

He, J., Yarbrough, D. K., Kreth, J., Anderson, M. H., Shi, W. & Eckert, R., May 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 5, p. 2143-2151 9 p.

Research output: Contribution to journalArticle

Streptococcus mutans
Peptides
Dental Caries
Biofilms
Saliva
2009
88 Citations (Scopus)

Bacterial and host interactions of oral streptococci

Kreth, J., Merritt, J. & Qi, F., Aug 1 2009, In : DNA and Cell Biology. 28, 8, p. 397-403 7 p.

Research output: Contribution to journalArticle

Biofilms
Streptococcus
Mouth Diseases
Ecology
Immune System
63 Citations (Scopus)

Characterization of hydrogen peroxide-induced DNA release by Streptococcus sanguinis and Streptococcus gordonii

Kreth, J., Vu, H., Zhang, Y. & Herzberg, M. C., Oct 1 2009, In : Journal of Bacteriology. 191, 20, p. 6281-6291 11 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
Streptococcus
Hydrogen Peroxide
DNA
Autolysis
16 Citations (Scopus)

Evaluation of bacteria-induced enamel demineralization using optical profilometry

Cross, S. E., Kreth, J., Wali, R. P., Sullivan, R., Shi, W. & Gimzewski, J. K., Dec 1 2009, In : Dental Materials. 25, 12, p. 1517-1526 10 p.

Research output: Contribution to journalArticle

Profilometry
Enamels
Dental Enamel
Tooth enamel
Biofilms
18 Citations (Scopus)

Influence of a model human defensive peroxidase system on oral streptococcal antagonism

Ashby, M. T., Kreth, J., Soundarajan, M. & Sivuilu, L. S., Nov 30 2009, In : Microbiology. 155, 11, p. 3691-3700 10 p.

Research output: Contribution to journalArticle

Streptococcus gordonii
Streptococcus mutans
Lactoperoxidase
Peroxidase
Streptococcus
7 Citations (Scopus)

Regulation of Prostate-Specific Antigen Expression by the Junctional Adhesion Molecule A

Wang, Q., Zheng, J. Y., Kreth, J., Yan, X., Kamata, M., Campbell, R. A., Xie, Y., Chiu, R., Berenson, J. R., Shi, W., Chen, I. S. Y. & Pang, S., May 1 2009, In : Urology. 73, 5, p. 1119-1125 7 p.

Research output: Contribution to journalArticle

Junctional Adhesion Molecule A
Prostate-Specific Antigen
Prostate
Proteins
Prostatic Neoplasms