• 3935 Citations
  • 34 h-Index
1979 …2018

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Article
2018

Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection

Slupe, A. M. & Kirsch, J., Jan 1 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Lean Strategies in the Operating Room

Robinson, S. & Kirsch, J., 2015, In : Anesthesiology Clinics. 33, 4, p. 713-730 18 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Barrier protection capacity of flip-top pharmaceutical vials

Hilliard, J. G., Cambronne, E. D., Kirsch, J. R. & Aziz, M. F., May 1 2013, In : Journal of Clinical Anesthesia. 25, 3, p. 177-180 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Local anesthetic schwann cell toxicity is time and concentration dependent

Yang, S., Abrahams, M. S., Hurn, P. D., Grafe, M. R. & Kirsch, J. R., Sep 1 2011, In : Regional anesthesia and pain medicine. 36, 5, p. 444-451 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
2009
15 Scopus citations
28 Scopus citations
2008

Can gender differences be evaluated in a rhesus macaque (macaca mulatto) model of focal cerebral ischemia?

Murphy, S. J., Kirsch, J. R., Zhang, W., Grafe, M. R., West, G. A., Del Zoppo, G. J., Traystman, R. J. & Hurn, P. D., Dec 1 2008, In : Comparative Medicine. 58, 6, p. 588-596 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2007

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

Yang, S., Bhardwaj, A., Cheng, J., Alkayed, N. J., Hurn, P. D. & Kirsch, J. R., May 1 2007, In : Anesthesia and analgesia. 104, 5, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

59 Scopus citations
2006

Sigma 1 receptor agonist act as neuroprotective drugs through inhibition of inducible nitric oxide synthase

Vagnerova, K., Hurn, P. D., Bhardwaj, A. & Kirsch, J. R., Aug 2006, In : Anesthesia and analgesia. 103, 2, p. 430-434 5 p.

Research output: Contribution to journalArticle

44 Scopus citations
2005
17 Scopus citations
2004

Prolonged opportunity for ischemic neuroprotection with selective κ-opioid receptor agonist in rats

Chen, T. Y., Goyagi, T., Toung, T. J. K., Kirsch, J. R., Hurn, P. D., Koehler, R. C. & Bhardwaj, A., May 1 2004, In : Stroke. 35, 5, p. 1180-1185 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Strategies for prophylaxis and treatment for aspiration

Kalinowski, C. P. H. & Kirsch, J. R., Dec 2004, In : Best Practice and Research: Clinical Anaesthesiology. 18, 4, p. 719-737 19 p.

Research output: Contribution to journalArticle

53 Scopus citations

Strategies of neuroprotection for intracranial aneurysms

Frietsch, T. & Kirsch, J. R., Dec 2004, In : Best Practice and Research: Clinical Anaesthesiology. 18, 4, p. 595-630 36 p.

Research output: Contribution to journalArticle

6 Scopus citations

The efficacy of the arrow staple device for securing central venous catheters to human skin

Motonaga, G. K., Lee, K. K. & Kirsch, J. R., Nov 1 2004, In : Anesthesia and analgesia. 99, 5, p. 1436-1439 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2003

Kappa-Opioid Receptor Selectivity for Ischemic Neuroprotection with BRL 52537 in Rats

Zhang, Z., Chen, T. Y., Kirsch, J. R., Toung, T. J. K., Traystman, R. J., Koehler, R. C., Hurn, P. D. & Bhardwaj, A., Dec 2003, In : Anesthesia and analgesia. 97, 6, p. 1776-1783 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Neuroprotective κ-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats

Goyagi, T., Toung, T. J. K., Kirsch, J. R., Traystman, R. J., Koehler, R. C., Hum, P. D. & Bhardwaj, A., Jun 1 2003, In : Stroke. 34, 6, p. 1533-1538 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Potent σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats

Goyagi, T., Bhardwaj, A., Koehler, R. C., Traystman, R. J., Hurn, P. D. & Kirsch, J. R., Feb 1 2003, In : Anesthesia and analgesia. 96, 2, p. 532-538 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
2002

Cerebral resuscitation: Role of osmotherapy

Harukuni, I., Kirsch, J. R. & Bhardwaj, A., Oct 21 2002, In : Journal of Anesthesia. 16, 3, p. 229-237 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2001

Anesthetic choice of halothane versus propofol impact on experimental perioperative stroke

Bhardwaj, A., Castro, A. F., Alkayed, N. J., Hurn, P. D. & Kirsch, J. R., Jan 1 2001, In : Stroke. 32, 8, p. 1920-1925 6 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Neuroprotective effect of σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

Goyagi, T., Goto, S., Bhardwaj, A., Dawson, V. L., Hurn, P. D. & Kirsch, J. R., Jan 1 2001, In : Stroke. 32, 7, p. 1613-1620 8 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations
2000

Administration of selective endothelin receptor type A antagonist Ro 61- 1790 does not improve outcome in focal cerebral ischemia in cat

Bhardwaj, A., Wu, Y., Hum, P. D., Kirsch, J. R. & Traystman, R. J., Jan 1 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 3, p. 499-504 6 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Antioxidant LY231617 enhances electrophysiologic recovery after global cerebral ischemia in dogs

Toung, T. J. K., Bhardwaj, A., Wang, M., Kirsch, J. R. & Traystman, R. J., Jan 1 2000, In : Critical care medicine. 28, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Oxotremorine-induced cerebral hyperemia does not predict infarction volume in spontaneously hypertensive or stroke-prone rats

Harukuni, I., Takahashi, H., Traystman, R. J., Bhardwaj, A. & Kirsch, J. R., Jan 1 2000, In : Critical care medicine. 28, 1, p. 190-195 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Society of neurosurgical anesthesia and critical care newsletter

Kirsch, J. R. & Sloan, T., Jul 2000, In : Journal of Neurosurgical Anesthesiology. 12, 3, 1 p.

Research output: Contribution to journalArticle

σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion

Harukuni, I., Bhardwaj, A., Shaivitz, A. B., DeVries, A. C., London, E. D., Hurn, P. D., Traystman, R. J. & Kirsch, J. R., Apr 2000, In : Stroke. 31, 4, p. 976-982 7 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations
1999
17 Scopus citations
1998

Intravenous basic fibroblast growth factor does not ameliorate brain injury resulting from transient focal ischemia in cats

Harukuni, I., Traystman, R. J., Bhardwaj, A., Koehler, R. C. & Kirsch, J. R., Jul 1998, In : Journal of Neurosurgical Anesthesiology. 10, 3, p. 160-165 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Neuroprotection from focal ischemia by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is dependent on treatment duration in rats

Harukuni, I., Bhardwaj, A., Traystman, R. J., Crain, B., London, E. D. & Kirsch, J. R., Dec 1998, In : Anesthesia and analgesia. 87, 6, p. 1299-1305 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Potent σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine modulates basal and N-methyl-D-aspartate-evoked nitric oxide production in vivo

Bhardwaj, A., Sawada, M., London, E. D., Koehler, R. C., Traystman, R. J. & Kirsch, J. R., Nov 1998, In : Stroke. 29, 11, p. 2404-2411 8 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

The effect of needle gauge and lidocaine pH on pain during intradermal injection

Palmon, S. C., Lloyd, A. T. & Kirsch, J. R., Mar 2 1998, In : Anesthesia and analgesia. 86, 2, p. 379-381 3 p.

Research output: Contribution to journalArticle

83 Scopus citations

The effect of the prone position on pulmonary mechanics is frame- dependent

Palmon, S. C., Kirsch, J. R., Depper, J. A. & Toung, T. J. K., Nov 14 1998, In : Anesthesia and analgesia. 87, 5, p. 1175-1180 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
1997

Comparative analysis of brain protection by N-methyl-D-aspartate receptor antagonists after transient focal ischemia in cats

Miyabe, M., Kirsch, J. R., Nishikawa, T., Koehler, R. C. & Traystman, R. J., Jun 1997, In : Critical care medicine. 25, 6, p. 1037-1043 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Intravenous basic fibroblast growth factor decrease brain injury resulting from focal ischemia in cats

Bethel, A., Kirsch, J. R., Koehler, R. C., Finklestein, S. P. & Traystman, R. J., Mar 1997, In : Stroke. 28, 3, p. 609-616 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Intraventricular dexmedetomidine decreases cerebral blood flow during normoxia and hypoxia in dogs

McPherson, R. W., Koehler, R. C., Kirsch, J. R. & Traystman, R. J., Jan 18 1997, In : Anesthesia and analgesia. 84, 1, p. 139-147 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Neither L-arginine nor L-NAME affects neurological outcome after global ischemia in cats

Kirsch, J. R., Bhardwaj, A., Martin, L. J., Hanley, D. F. & Traystman, R. J., Nov 1997, In : Stroke. 28, 11, p. 2259-2265 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Postischemic brain injury is affected stereospecifically by pentazocine in rats

Takahashi, H., Traystman, R. J., Hashimoto, K., London, E. D. & Kirsch, J. R., Aug 1 1997, In : Anesthesia and analgesia. 85, 2, p. 353-357 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

The role of nitric oxide in the control of the cerebral circulation

Palmon, S. C. & Kirsch, J. R., Jan 1 1997, In : Problems in Anesthesia. 9, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

1996

Capnography facilitates tight control of ventilation during transport

Palmon, S. C., Liu, M., Moore, L. E. & Kirsch, J. R., Apr 1 1996, In : Critical care medicine. 24, 4, p. 608-611 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Correlation of the average water diffusion constant with cerebral blood flow and ischemic damage after transient middle cerebral artery occlusion in cats

Miyabe, M., Mori, S., Van Zijl, P. C. M., Kirsch, J. R., Eleff, S. M., Koehler, R. C. & Traystman, R. J., 1996, In : Journal of Cerebral Blood Flow and Metabolism. 16, 5, p. 881-891 11 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Enhanced recovery of brain electrical activity by adenosine 3′,5′-cyclic monophosphate following complete global cerebral ischemia in dogs

Toung, T. J. K., Kirsch, J. R. & Traystman, R. J., Jan 1 1996, In : Critical care medicine. 24, 1 SUPPL., p. 103-108 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Intensity of halothane- and hypercapnia-induced cerebral hyperemia is strain-dependent in rats

Takahashi, H., Kirsch, J. R., Okada, T. & Traystman, R. J., Aug 16 1996, In : Anesthesia and analgesia. 83, 2, p. 359-365 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats

Takahashi, H., Kirsch, J. R., Hashimoto, K., London, E. D., Koehler, R. C. & Traystman, R. J., Nov 1996, In : Stroke. 27, 11, p. 2120-2123 4 p.

Research output: Contribution to journalArticle

49 Scopus citations
1995

Cerebral blood flow during cardiopulmonary bypass: Influence of temperature and pH management strategy

Cheng, W., Hartmann, J. F., Cameron, D. E., Griffiths, E. M., Kirsch, J. R. & Traystman, R. J., Jan 1 1995, In : Annals of Thoracic Surgery. 59, 4, p. 880-886 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cerebral blood flow during inhibition of brain nitric oxide synthase activity in normal, hypertensive, and stroke-prone rats

Izuta, M., Clavier, N., Kirsch, J. R. & Traystman, R. J., Jun 1995, In : Stroke. 26, 6, p. 1079-1085 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effect of nitric oxide synthase inhibition on postischemic cerebral hyperemia

Greenberg, R. S., Helfaer, M. A., Kirsch, J. R. & Traystman, R. J., 1995, In : American Journal of Physiology - Heart and Circulatory Physiology. 269, 1 38-1, p. H341-H347

Research output: Contribution to journalArticle

27 Scopus citations

Effect of nitric oxide synthase inhibition on the cerebral vascular response to hypercapnia in primates

McPherson, R. W., Kirsch, J. R., Ghaly, R. F. & Traystman, R. J., Apr 1995, In : Stroke. 26, 4, p. 682-687 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Postischemic cerebral blood flow recovery in the female: Effect of 17β-estradiol

Hurn, P. D., Littleton-Kearney, M. T., Kirsch, J. R., Dharmarajan, A. M. & Traystman, R. J., Jan 1 1995, In : Journal of Cerebral Blood Flow and Metabolism. 15, 4, p. 666-672 7 p.

Research output: Contribution to journalArticle

Open Access
129 Scopus citations

Ppbp [4-phenyl-1-(4-phenylbutyl) piperidine], a potent sigma-receptor ligand, decreases brain injury after transient focal ischemia in cats

Takahashi, H., Kirsch, J. R., Hashimoto, K., London, E. D., Koehler, R. C. & Traystman, R. J., Sep 1995, In : Stroke. 26, 9, p. 1676-1682 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Time-dependent inhibition of oxotremorine-induced cerebral hyperemia by n sup omega-nitro-l-arginine in cats

Tietjen, C. S., Kirsch, J. R., Clavier, N. & Traystman, R. J., Nov 1995, In : Stroke. 26, 11, p. 2160-2165 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Tirilazad pretreatment improves early cerebral metabolic and blood flow recovery from hyperglycemic ischemia

Maruki, Y., Koehler, R. C., Kirsch, J. R., Blizzard, K. K. & Traystman, R. J., Jan 1 1995, In : Journal of Cerebral Blood Flow and Metabolism. 15, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

21 Scopus citations