Jeffrey Iliff

Associate Professor

  • 4692 Citations
  • 25 h-Index
20032020
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Research Output 2003 2019

  • 4692 Citations
  • 25 h-Index
  • 43 Article
  • 1 Chapter
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Article
2019

Analysis of convective and diffusive transport in the brain interstitium

Ray, L., Iliff, J. & Heys, J. J., Mar 6 2019, In : Fluids and Barriers of the CNS. 16, 1, 6.

Research output: Contribution to journalArticle

Open Access
Brain
Convection
Research Personnel
Neuropathology
2018
5 Citations (Scopus)

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Mestre, H., Hablitz, L. M., Xavier, A. L. R., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Rivera, R. M. C., Simon, M. J., Pike, M., Plá, V., Du, T., Kress, B. T., Wang, X., Plog, B. A., Thrane, A. S., Lundgaard, I., Abe, Y., Yasui, M. & 6 othersThomas, J. H., Xiao, M., Hirase, H., Asokan, A., Iliff, J. & Nedergaard, M., Dec 1 2018, In : eLife. 7, e40070.

Research output: Contribution to journalArticle

Aquaporin 4
Solute transport
Cerebrospinal fluid
Rodentia
Brain
3 Citations (Scopus)

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects

Goodman, J. R., Adham, Z. O., Woltjer, R. R., Lund, A. & Iliff, J., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Alzheimer Disease
Meninges
Lymphatic Vessels
Brain
Amyloid
2 Citations (Scopus)
Magnetic Resonance Imaging
Health Insurance Portability and Accountability Act
Informed Consent
Dementia
Protons
Vascular Dementia
Alzheimer Disease
Aquaporin 4
Dementia
Pathology
1 Citation (Scopus)

Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

Simon, M. J., Wang, M. X., Murchison, C. F., Roese, N. E., Boespflug, E., Woltjer, R. R. & Iliff, J., Dec 1 2018, In : Scientific Reports. 8, 1, 12389.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Dementia
Aquaporin 4
Pathology
Alzheimer Disease
2017
47 Citations (Scopus)

Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains

Zeppenfeld, D. M., Simon, M., Haswell, J. D., D'Abreo, D., Murchison, C., Quinn, J., Grafe, M., Woltjer, R. R., Kaye, J. & Iliff, J., Jan 1 2017, In : JAMA Neurology. 74, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

Aquaporin 4
Cognition
Alzheimer Disease
Brain
Amyloid
2 Citations (Scopus)

A transcriptome-based assessment of the astrocytic dystrophin-associated complex in the developing human brain

Simon, M. J., Murchison, C. & Iliff, J., 2017, (Accepted/In press) In : Journal of Neuroscience Research.

Research output: Contribution to journalArticle

Dystrophin
Transcriptome
Brain
Genes
Aquaporin 4
30 Citations (Scopus)

Focal solute trapping and global glymphatic pathway impairment in a murine model of multiple microinfarcts

Wang, M., Ding, F., Deng, S. Y., Guo, X., Wang, W., Iliff, J. & Nedergaard, M., Mar 15 2017, In : Journal of Neuroscience. 37, 11, p. 2870-2877 8 p.

Research output: Contribution to journalArticle

Brain
Alzheimer Disease
Intra-Arterial Injections
Vascular Dementia
Amyloid Plaques
13 Citations (Scopus)
Aquaporin 4
Cognition
Single Nucleotide Polymorphism
Alzheimer Disease
Brain
12 Citations (Scopus)
Extracellular Fluid
Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Sleep
2016
5 Citations (Scopus)

Methamphetamine induces the release of endothelin

Seo, J. W., Jones, S. M., Hostetter, T. A., Iliff, J. & West, G. A., Feb 1 2016, In : Journal of Neuroscience Research. 94, 2, p. 170-178 9 p.

Research output: Contribution to journalArticle

Methamphetamine
Endothelins
Endothelin-1
Vasoconstriction
Nitric Oxide Synthase Type III
51 Citations (Scopus)
Cerebrospinal Fluid
Brain
Neuroglia
Blood Vessels
Extracellular Fluid
2015
62 Citations (Scopus)

Implications of the discovery of brain lymphatic pathways

Iliff, J., Goldman, S. A. & Nedergaard, M., Oct 1 2015, In : The Lancet Neurology. 14, 10, p. 977-979 3 p., 153.

Research output: Contribution to journalArticle

Macromolecular Substances
Lymphatic System
Extracellular Fluid
Cerebrospinal Fluid
Lymph Nodes
2014
10 Citations (Scopus)

A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation

Plog, B. A., Moll, K. M., Kang, H., Iliff, J., Dashnaw, M. L., Nedergaard, M. & Vates, G. E., May 30 2014, In : Journal of Neuroscience Methods. 229, p. 44-52 9 p.

Research output: Contribution to journalArticle

Microglia
Subarachnoid Hemorrhage
Aptitude
Internal-External Control
Confocal Microscopy
6 Citations (Scopus)

Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease

Cotrina, M. L., Chen, M., Han, X., Iliff, J., Ren, Z., Sun, W., Hagemann, T., Goldman, J., Messing, A. & Nedergaard, M., Sep 25 2014, In : Brain Research. 1582, p. 211-219 9 p.

Research output: Contribution to journalArticle

Alexander Disease
Glial Fibrillary Acidic Protein
Seizures
Astrocytes
Mutation
229 Citations (Scopus)

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

Iliff, J., Chen, M. J., Plog, B. A., Zeppenfeld, D. M., Soltero, M., Yang, L., Singh, I., Deane, R. & Nedergaard, M., Dec 3 2014, In : Journal of Neuroscience. 34, 49, p. 16180-16193 14 p.

Research output: Contribution to journalArticle

Pathology
Brain
Aquaporin 4
tau Proteins
Gene Knockout Techniques
251 Citations (Scopus)

Impairment of paravascular clearance pathways in the aging brain

Kress, B. T., Iliff, J., Xia, M., Wang, M., Wei Bs, H. S., Zeppenfeld, D., Xie, L., Hongyi Kang, B. S., Xu, Q., Liew, J. A., Plog, B. A., Ding, F., PhD, R. D. & Nedergaard, M., Dec 1 2014, In : Annals of Neurology. 76, 6, p. 845-861 17 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Extracellular Fluid
Brain
Aquaporin 4
Aquaporins
60 Citations (Scopus)

The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy

Petraglia, A., Plog, B., Dayawansa, S., Dashnaw, M., Czerniecka, K., Walker, C., Chen, M., Hyrien, O., Iliff, J., Deane, R., Huang, J. & Nedergaard, M., Jan 1 2014, In : Surgical Neurology International. 5, 1

Research output: Contribution to journalArticle

Brain Concussion
tau Proteins
Animal Models
Gliosis
Glial Fibrillary Acidic Protein
95 Citations (Scopus)

The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: A novel mouse model of chronic traumatic encephalopathy

Petraglia, A. L., Plog, B. A., Dayawansa, S., Chen, M., Dashnaw, M. L., Czerniecka, K., Walker, C. T., Viterise, T., Hyrien, O., Iliff, J., Deane, R., Nedergaard, M. & Huang, J. H., Jul 1 2014, In : Journal of Neurotrauma. 31, 13, p. 1211-1224 14 p.

Research output: Contribution to journalArticle

Brain Concussion
Hand Strength
Risk-Taking
Sleep
Anxiety
2013
4 Citations (Scopus)

A link between glial Ca2+ signaling and hypoxia in aging?

Iliff, J. & Nedergaard, M., Feb 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 2, p. 170 1 p.

Research output: Contribution to journalArticle

Brain Hypoxia
Calcium Signaling
Purkinje Cells
Neuroglia
Oxygen
283 Citations (Scopus)

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

Iliff, J., Lee, H., Yu, M., Feng, T., Logan, J., Nedergaard, M. & Benveniste, H., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 1299-1309 11 p.

Research output: Contribution to journalArticle

Extracellular Fluid
Cerebrospinal Fluid
Brain
Disease Progression
Alzheimer Disease
255 Citations (Scopus)

Cerebral arterial pulsation drives paravascular CSF-Interstitial fluid exchange in the murine brain

Iliff, J., Wang, M., Zeppenfeld, D. M., Venkataraman, A., Plog, B. A., Liao, Y., Deane, R. & Nedergaard, M., 2013, In : Journal of Neuroscience. 33, 46, p. 18190-18199 10 p.

Research output: Contribution to journalArticle

Extracellular Fluid
Brain
Dobutamine
Internal Carotid Artery
Photons
117 Citations (Scopus)

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

Yang, L., Kress, B. T., Weber, H. J., Thiyagarajan, M., Wang, B., Deane, R., Benveniste, H., Iliff, J. & Nedergaard, M., May 1 2013, In : Journal of Translational Medicine. 11, 1, 107.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Cerebrospinal Fluid
Brain
Neurodegenerative diseases
Extracellular Fluid
89 Citations (Scopus)

'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation

Ren, Z., Iliff, J., Yang, L., Yang, J., Chen, X., Chen, M. J., Giese, R. N., Wang, B., Shi, X. & Nedergaard, M., Jun 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 6, p. 834-845 12 p.

Research output: Contribution to journalArticle

Aquaporin 4
Skull
Brain Edema
Intracranial Pressure
Wounds and Injuries
124 Citations (Scopus)

Is there a cerebral lymphatic system?

Iliff, J. & Nedergaard, M., Jan 2013, In : Stroke. 44, SUPPL. 1

Research output: Contribution to journalArticle

Aquaporin 4
Lymphatic System
Lymphatic Vessels
Gliosis
Amyloid beta-Peptides
64 Citations (Scopus)

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

Thrane, V. R., Thrane, A. S., Plog, B. A., Thiyagarajan, M., Iliff, J., Deane, R., Nagelhus, E. A. & Nedergaard, M., 2013, In : Scientific Reports. 3, 2582.

Research output: Contribution to journalArticle

Microcirculation
Astrocytes
Lipids
Blood Vessels
Brain
1134 Citations (Scopus)

Sleep drives metabolite clearance from the adult brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O'Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J., Takano, T., Deane, R. & Nedergaard, M., 2013, In : Science. 342, 6156, p. 373-377 5 p.

Research output: Contribution to journalArticle

Sleep
Brain
Extracellular Fluid
Waste Products
Photons
2012
1103 Citations (Scopus)

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β

Iliff, J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., Nagelhus, E. A. & Nedergaard, M., Aug 15 2012, In : Science Translational Medicine. 4, 147, 147ra111.

Research output: Contribution to journalArticle

Amyloid
Cerebrospinal Fluid
Brain
Aquaporin 4
Aquaporins
59 Citations (Scopus)

Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts

Wang, M., Iliff, J., Liao, Y., Chen, M. J., Shinseki, M. S., Venkataraman, A., Cheung, J., Wang, W. & Nedergaard, M., Dec 12 2012, In : Journal of Neuroscience. 32, 50, p. 17948-17960 13 p.

Research output: Contribution to journalArticle

Stroke
Gliosis
Demyelinating Diseases
Aquaporin 4
Aquaporins
2010
73 Citations (Scopus)

Epoxyeicosanoid signaling in CNS function and disease

Iliff, J., Jia, J., Nelson, J., Goyagi, T., Klaus, J. & Alkayed, N., Apr 2010, In : Prostaglandins and Other Lipid Mediators. 91, 3-4, p. 68-84 17 p.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Neurology
Central Nervous System
Brain Ischemia
Cytochrome P-450 Enzyme System
19 Citations (Scopus)

Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons

Iliff, J., Fairbanks, S. L., Balkowiec, A. & Alkayed, N., Dec 2010, In : Journal of Neurochemistry. 115, 6, p. 1530-1542 13 p.

Research output: Contribution to journalArticle

Trigeminal Ganglion
Calcitonin Gene-Related Peptide
Neuropeptides
Neurons
Acids
2009
14 Citations (Scopus)

Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage

Cetas, J., Lee, D. R., Alkayed, N., Wang, R., Iliff, J. & Heinricher, M., Oct 6 2009, In : Neuroscience. 163, 2, p. 719-729 11 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Subarachnoid Hemorrhage
Brain Stem
Perfusion
Ischemia
50 Citations (Scopus)
Epoxide Hydrolases
Cerebrovascular Circulation
Vasodilation
Ganglia
Trigeminal Ganglion
49 Citations (Scopus)

Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia

Zhang, W., Iliff, J., Campbell, C. J., Wang, R. K., Hurn, P. D. & Alkayed, N., Aug 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 8, p. 1475-1481 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Brain Ischemia
Blood Vessels
Middle Cerebral Artery Infarction
Knockout Mice
42 Citations (Scopus)
Epoxide Hydrolases
Brain Injuries
Stroke
Eicosanoids
Gene Deletion
2008
7 Citations (Scopus)

In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide

Iliff, J., Alkayed, N., Golshani, K. J., Weinstein, J., Traystman, R. J. & West, G. A., Jul 2008, In : Journal of Cardiovascular Pharmacology. 52, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Peptides
Constriction
Arterioles
135 Citations (Scopus)

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang, W., Otsuka, T., Sugo, N., Ardeshiri, A., Alhadid, Y. K., Iliff, J., De Barber, A., Koop, D. & Alkayed, N., Jul 2008, In : Stroke. 39, 7, p. 2073-2078 6 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Gene Deletion
Brain Ischemia
Knockout Mice
Middle Cerebral Artery Infarction
76 Citations (Scopus)

Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo

Motoki, A., Merkel, M., Packwood, W. H., Cao, Z., Liu, L., Iliff, J., Alkayed, N. & Van Winkle, D. M., Nov 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 5

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Epoxide Hydrolases
Gene Deletion
Reperfusion Injury
Myocardial Ischemia
2007
45 Citations (Scopus)

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat

Iliff, J., Close, L. N., Selden, N. & Alkayed, N., Jul 2007, In : Experimental Physiology. 92, 4, p. 653-658 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Epoxide Hydrolases
Eicosanoids
Cytochrome P-450 Enzyme System
Acids

Soluble epoxide hydrolase: Sex differences and role in estrogen-mediated neuroprotection

Zhang, W., Iliff, J., Alhadid, Y. K., Ardeshiri, A., Koerner, I., Hurn, P. D. & Alkayed, N., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Epoxide Hydrolases
Sex Characteristics
Estrogens
Reperfusion
Middle Cerebral Artery Infarction
2005
20 Citations (Scopus)

Cocaine- and amphetamine-regulated transcript (CART) peptide: A vasoactive role in the cerebral circulation

Iliff, J., Alkayed, N., Gloshani, K. J., Traystman, R. J. & West, G. A., Oct 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 10, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Amphetamine
Cocaine
Peptides
Arterioles
2003
44 Citations (Scopus)

Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex

Iliff, J., D'Ambrosio, R., Ngai, A. C. & Winn, H. R., May 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

Purinergic P1 Receptors
Cerebral Cortex
Arterioles
Dilatation
Glutamic Acid