Jeanne Link

Professor, Provisional

  • 5082 Citations
  • 44 h-Index
1985 …2018
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Research Output 1985 2018

  • 5082 Citations
  • 44 h-Index
  • 93 Article
  • 5 Conference contribution
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Article
2018
2 Citations

Hydroxamate column-based purification of zirconium-89 (89Zr) using an automated fluidic platform

O'Hara, M. J., Murray, N. J., Carter, J. C., Kellogg, C. M. & Link, J. M. Feb 1 2018 In : Applied Radiation and Isotopes. 132, p. 85-94 10 p.

Research output: Contribution to journalArticle

fluidics
purification
platforms
resins
products

Molecular Imaging in Drug Discovery and Development

Lindner, J. R. & Link, J. Feb 1 2018 In : Circulation: Cardiovascular Imaging. 11, 2, e005355

Research output: Contribution to journalArticle

Molecular Imaging
Drug Discovery
Medicine
Pharmaceutical Preparations
Drug Approval
2017
2 Citations

A simple thick target for production of 89Zr using an 11 MeV cyclotron

Link, J. M., Krohn, K. A. & O'Hara, M. J. Apr 1 2017 In : Applied Radiation and Isotopes. 122, p. 211-214 4 p.

Research output: Contribution to journalArticle

cyclotrons
foils
radiochemistry
yttrium
availability
12 Citations

Estrogen receptor binding (18F-FES PET) and glycolytic activity (18F-FDG PET) predict progression-free survival on endocrine therapy in patients with ER+ breast cancer

Kurland, B. F., Peterson, L. M., Lee, J. H., Schubert, E. K., Currin, E. R., Link, J. M., Krohn, K. A., Mankoff, D. A. & Linden, H. M. Jan 15 2017 In : Clinical Cancer Research. 23, 2, p. 407-415 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Disease-Free Survival
Breast Neoplasms
Aromatase Inhibitors
Neoplasms
2016

Assessment of the effects of age, gender, and exercise training on the cardiac sympathetic nervous system using positron emission tomography imaging

Bernacki, G. M., Bahrainy, S., Caldwell, J. H., Levy, W. C., Link, J. M. & Stratton, J. R. Sep 1 2016 In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 9, p. 1195-1201 7 p.

Research output: Contribution to journalArticle

Sympathetic Nervous System
Positron-Emission Tomography
Exercise
Healthy Volunteers
Norepinephrine Plasma Membrane Transport Proteins
2 Citations

Temporal heterogeneity of estrogen receptor expression in bone-dominant breast cancer: 18f-fluoroestradiol pet imaging shows return of er expression

Currin, E., Peterson, L. M., Schubert, E. K., Link, J. M., Krohn, K. A., Livingston, R. B., Mankoff, D. A. & Linden, H. M. Feb 1 2016 In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 2, p. 144-147 4 p.

Research output: Contribution to journalArticle

Pets
Estrogen Receptors
Breast Neoplasms
Bone and Bones
Therapeutics
2015
11 Citations

Applications of PET imaging with the proliferation marker [18F]-FLT

Peck, M., Pollack, H. A., Friesen, A., Muzi, M., Shoner, S. C., Shankland, E. G., Fink, J. R., Armstrong, J. O., Link, J. M. & Krohn, K. A. Mar 1 2015 In : Quarterly Journal of Nuclear Medicine and Molecular Imaging. 59, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Cell Proliferation
Clinical Protocols
Neoplasms
Thymidine Kinase
14 Citations

Modulation of P-glycoprotein at the human blood-brain barrier by quinidine or rifampin treatment: A positron emission tomography imaging study

Liu, L., Collier, A. C., Link, J. M., Domino, K. B., Mankoff, D. A., Eary, J. F., Spiekerman, C. F., Hsiao, P., Deo, A. K. & Unadkat, J. D. Nov 1 2015 In : Drug Metabolism and Disposition. 43, 11, p. 1795-1804 10 p.

Research output: Contribution to journalArticle

Quinidine
P-Glycoprotein
Rifampin
Blood-Brain Barrier
Positron-Emission Tomography
2 Citations

Publish or perish. .but where? What is the value of impact factors?

Link, J. M. May 1 2015 In : Nuclear Medicine and Biology. 42, 5, p. 426-427 2 p.

Research output: Contribution to journalArticle

Journal Impact Factor
2014
47 Citations

Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease

Deo, A. K., Borson, S., Link, J. M., Domino, K., Eary, J. F., Ke, B., Richards, T. L., Mankoff, D. A., Minoshima, S., O'Sullivan, F., Eyal, S., Hsiao, P., Maravilla, K. & Unadkat, J. D. Jul 1 2014 In : Journal of Nuclear Medicine. 55, 7, p. 1106-1111 6 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Blood-Brain Barrier
Amyloid
Cerebrovascular Circulation
Alzheimer Disease
34 Citations

A phase 2 study of 16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC)

Peterson, L. M., Kurland, B. F., Schubert, E. K., Link, J. M., Gadi, V. K., Specht, J. M., Eary, J. F., Porter, P., Shankar, L. K., Mankoff, D. A. & Linden, H. M. 2014 In : Molecular Imaging and Biology. 16, 3, p. 431-440 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Positron-Emission Tomography
Estradiol
Hormones
Breast Neoplasms
26 Citations

PET imaging of oatp-mediated hepatobiliary transport of [11C] rosuvastatin in the rat

He, J., Yu, Y., Prasad, B., Link, J., Miyaoka, R. S., Chen, X. & Unadkat, J. D. Aug 4 2014 In : Molecular Pharmaceutics. 11, 8, p. 2745-2754 10 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Liver
Area Under Curve
Kidney
Radioactivity
2013
20 Citations
P-Glycoprotein
Primates
Cyclosporine
Mothers
Ligands
3 Citations

The future of USP monographs for PET drugs

Schwarz, S., Norenberg, J., Berridge, M., Dragotakes, S., Hung, J., Link, J., Mason, N. S., Mattmuller, S., Nickel, R. A., Packard, A., Paolino, J., Petry, N., Ponto, J., Quinton, T. M., Seifert, K. L., Swanson, D., Weiner, R. E. & Zigler, S. Mar 1 2013 In : Journal of Nuclear Medicine. 54, 3, p. 472-475 4 p.

Research output: Contribution to journalArticle

Drug Legislation
Investigational Drugs
Drug Compounding
Radiopharmaceuticals
United States Food and Drug Administration
2011
39 Citations

Between-patient and within-patient (site-to-site) variability in estrogen receptor binding, measured in vivo by 18F-fluoroestradiol PET

Kurland, B. F., Peterson, L. M., Lee, J. H., Linden, H. M., Schubert, E. K., Dunnwald, L. K., Link, J. M., Krohn, K. A. & Mankoff, D. A. Oct 1 2011 In : Journal of Nuclear Medicine. 52, 10, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Confidence Intervals
Observer Variation
Estrogens
60 Citations

C11-acetate and F-18 FDG PET for men with prostate cancer bone metastases: Relative findings and response to therapy

Yu, E. Y., Muzi, M., Hackenbracht, J. A., Rezvani, B. B., Link, J. M., Montgomery, R. B., Higano, C. S., Eary, J. F. & Mankoff, D. A. Mar 2011 In : Clinical Nuclear Medicine. 36, 3, p. 192-198 7 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Fluorodeoxyglucose F18
Positron-Emission Tomography
Prostatic Neoplasms
Acetates
32 Citations

Factors influencing the uptake of 18F-fluoroestradiol in patients with estrogen receptor positive breast cancer

Peterson, L. M., Kurland, B. F., Link, J. M., Schubert, E. K., Stekhova, S., Linden, H. M. & Mankoff, D. A. Oct 2011 In : Nuclear Medicine and Biology. 38, 7, p. 969-978 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Sex Hormone-Binding Globulin
Breast Neoplasms
Estradiol
Neoplasms
69 Citations

Fluoroestradiol positron emission tomography reveals differences in pharmacodynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer

Linden, H. M., Kurland, B. F., Peterson, L. M., Schubert, E. K., Gralow, J. R., Specht, J. M., Ellis, G. K., Lawton, T. J., Livingston, R. B., Petra, P. H., Link, J. M., Krohn, K. A. & Mankoff, D. A. Jul 15 2011 In : Clinical Cancer Research. 17, 14, p. 4799-4805 7 p.

Research output: Contribution to journalArticle

Aromatase Inhibitors
Tamoxifen
Estrogen Receptors
Positron-Emission Tomography
Breast Neoplasms
16 Citations

Multiagent PET for risk characterization in sarcoma

Eary, J. F., Link, J. M., Muzi, M., Conrad, E. U., Mankoff, D. A., White, J. K. & Krohn, K. A. Apr 1 2011 In : Journal of Nuclear Medicine. 52, 4, p. 541-546 6 p.

Research output: Contribution to journalArticle

Sarcoma
Neoplasms
P-Glycoprotein
Cell Proliferation
Molecular Imaging
2010
22 Citations

Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate

Chung, F. S., Eyal, S., Muzi, M., Link, J. M., Mankoff, D. A., Kaddoumi, A., O'Sullivan, F., Hsiao, P. & Unadkat, J. D. Jan 2010 In : British Journal of Pharmacology. 159, 2, p. 394-404 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Positron-Emission Tomography
Primates
Area Under Curve
Pregnancy
46 Citations

Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography

Eyal, S., Ke, B., Muzi, M., Link, J. M., Mankoff, D. A., Collier, A. C. & Unadkat, J. D. May 2010 In : Clinical Pharmacology and Therapeutics. 87, 5, p. 579-585 7 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Blood-Brain Barrier
Positron-Emission Tomography
Brain
Verapamil
2009
1 Citations
Carbon Radioisotopes
Cine Magnetic Resonance Imaging
Quinuclidinyl Benzilate
Predictive Value of Tests
Muscarinic Antagonists
81 Citations

Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: Studies of healthy humans

Muzi, M., Mankoff, D. A., Link, J. M., Shoner, S., Collier, A. C., Sasongko, L. & Unadkat, J. D. Aug 1 2009 In : Journal of Nuclear Medicine. 50, 8, p. 1267-1275 9 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Verapamil
Cyclosporine
Brain
Blood-Brain Barrier
45 Citations
Glioma
Positron-Emission Tomography
Safety
Glucose
Recurrence
33 Citations

Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate

Eyal, S., Chung, F. S., Muzi, M., Link, J. M., Mankoff, D. A., Kaddoumi, A., O'Sullivan, F., Hebert, M. F. & Unadkat, J. D. May 1 2009 In : Journal of Nuclear Medicine. 50, 5, p. 798-806 9 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Primates
Cyclosporine
Radioactivity
Verapamil
2008
16 Citations

Diagnostic and prognostic imaging of the cardiac sympathetic nervous system

Link, J. M. & Caldwell, J. H. Aug 2008 In : Nature Clinical Practice Cardiovascular Medicine. 5, SUPPL. 2

Research output: Contribution to journalArticle

Sympathetic Nervous System
Diagnostic Imaging
Norepinephrine
Norepinephrine Plasma Membrane Transport Proteins
Presynaptic Receptors
63 Citations

Evidence for pre- to postsynaptic mismatch of the cardiac sympathetic nervous system in ischemic congestive heart failure

Caldwell, J. H., Link, J. M., Levy, W. C., Poole, J. E. & Stratton, J. R. Feb 1 2008 In : Journal of Nuclear Medicine. 49, 2, p. 234-241 8 p.

Research output: Contribution to journalArticle

Sympathetic Nervous System
Heart Failure
Healthy Volunteers
Norepinephrine
Receptors, Adrenergic, beta
317 Citations

Molecular imaging of hypoxia

Krohn, K. A., Link, J. M. & Mason, R. P. Jun 1 2008 In : Journal of Nuclear Medicine. 49, SUPPL.6

Research output: Contribution to journalArticle

Molecular Imaging
Blood Vessels
Molecular Probes
Nuclear Medicine
Glycolysis
9 Citations

NCI-Sponsored trial for the evaluation of safety and preliminary efficacy of FLT as a marker of proliferation in patients with recurrent gliomas: Safety studies

Spence, A. M., Muzi, M., Link, J. M., Hoffman, J. M., Eary, J. F. & Krohn, K. A. 2008 In : Molecular Imaging and Biology. 10, 5, p. 271-280 10 p.

Research output: Contribution to journalArticle

Anti-Retroviral Agents
Vital Signs
Poisons
Neurologic Examination
Hematologic Tests
134 Citations

Quantitative imaging of estrogen receptor expression in breast cancer with PET and 18F-fluoroestradiol

Peterson, L. M., Mankoff, D. A., Lawton, T., Yagle, K., Schubert, E. K., Stekhova, S., Gown, A., Link, J. M., Tewson, T. & Krohn, K. A. Mar 1 2008 In : Journal of Nuclear Medicine. 49, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Immunohistochemistry
Neoplasms
Research Design
11 Citations

Rapid solid-phase extraction method to quantify [11C]-verapamil, and its [11C]-metabolites, in human and macaque plasma

Unadkat, J. D., Chung, F., Sasongko, L., Whittington, D., Eyal, S., Mankoff, D., Collier, A. C., Muzi, M. & Link, J. Nov 2008 In : Nuclear Medicine and Biology. 35, 8, p. 911-917 7 p.

Research output: Contribution to journalArticle

Solid Phase Extraction
Macaca
Verapamil
P-Glycoprotein
Primates
157 Citations

Regional hypoxia in glioblastoma multiforme quantified with [ 18F] fluoromisonidazole positron emission tomography before radiotherapy: Correlation with time to progression and survival

Spence, A. M., Muzi, M., Swanson, K. R., O'Sullivan, F., Rockhill, J. K., Rajendran, J. G., Adamsen, T. C. H., Link, J. M., Swanson, P. E., Yagle, K. J., Rostomily, R. C., Silbergeld, D. L. & Krohn, K. A. May 1 2008 In : Clinical Cancer Research. 14, 9, p. 2623-2630 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Positron-Emission Tomography
Radiotherapy
Survival
Tumor Burden
75 Citations

Site-specific labeling of annexin V with F-18 for apoptosis imaging

Li, X., Link, J. M., Stekhova, S., Yagle, K. J., Smith, C., Krohn, K. A. & Tait, J. F. Aug 2008 In : Bioconjugate Chemistry. 19, 8, p. 1684-1688 5 p.

Research output: Contribution to journalArticle

Annexin A5
Cell death
Labeling
Apoptosis
Imaging techniques
112 Citations

Tumor receptor imaging

Mankoff, D. A., Link, J. M., Linden, H. M., Sundararajan, L. & Krohn, K. A. Jun 1 2008 In : Journal of Nuclear Medicine. 49, SUPPL.6

Research output: Contribution to journalArticle

Neoplasms
Molecular Imaging
Estrogen Receptors
Breast Neoplasms
Somatostatin Receptors
2007
48 Citations

18F-Fluoroestradiol

Sundararajan, L., Linden, H. M., Link, J. M., Krohn, K. A. & Mankoff, D. A. Nov 2007 In : Seminars in Nuclear Medicine. 37, 6, p. 470-476 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Positron-Emission Tomography
Breast Neoplasms
Aromatase Inhibitors
Selection Bias
10 Citations

Challenges in clinical studies with multiple imaging probes

Krohn, K. A., O'Sullivan, F., Crowley, J., Eary, J. F., Linden, H. M., Link, J. M., Mankoff, D. A., Muzi, M., Rajendran, J. G., Spence, A. M. & Swanson, K. R. Oct 2007 In : Nuclear Medicine and Biology. 34, 7, p. 879-885 7 p.

Research output: Contribution to journalArticle

Molecular Imaging
Biochemical Phenomena
Therapeutics
Biomarkers
Validation Studies
92 Citations

Tumor-specific positron emission tomography imaging in patients: [ 18F] fluorodeoxyglucose and beyond

Mankoff, D. A., Eary, J. F., Link, J. M., Muzi, M., Rajendran, J. G., Spence, A. M. & Krohn, K. A. Jun 15 2007 In : Clinical Cancer Research. 13, 12, p. 3460-3469 10 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Positron-Emission Tomography
Neoplasms
Molecular Imaging
Radiopharmaceuticals
2006
64 Citations

[11C]Metahydroxyephedrine and [18F]fluorodeoxyglucose positron emission tomography improve clinical decision making in suspected pheochromocytoma

Mann, G. N., Link, J. M., Pham, P., Pickett, C. A., Byrd, D. R., Kinahan, P. E., Krohn, K. A. & Mankoff, D. A. Feb 2006 In : Annals of Surgical Oncology. 13, 2, p. 187-197 11 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Pheochromocytoma
Positron-Emission Tomography
Torso
Clinical Decision-Making
98 Citations

Kinetic analysis of 3′-deoxy-3′-18F-fluorothymidine in patients with gliomas

Muzi, M., Spence, A. M., O'Sullivan, F., Mankoff, D. A., Wells, J. M., Grierson, J. R., Link, J. M. & Krohn, K. A. Oct 1 2006 In : Journal of Nuclear Medicine. 47, 10, p. 1612-1621 10 p.

Research output: Contribution to journalArticle

Glioma
Neoplasms
Blood-Brain Barrier
Gadolinium
Thymidine
268 Citations

Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer

Linden, H. M., Stekhova, S. A., Link, J. M., Gralow, J. R., Livingston, R. B., Ellis, G. K., Petra, P. H., Peterson, L. M., Schubert, E. K., Dunnwald, L. K., Krohn, K. A. & Mankoff, D. A. Jun 20 2006 In : Journal of Clinical Oncology. 24, 18, p. 2793-2799 7 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Breast Neoplasms
Therapeutics
Tamoxifen
Estrogen Receptors

Reply

Unadkat, J. D., Link, J. M., Mankoff, D. A., Muzi, M. & Collier, A. C. Sep 2006 In : Clinical Pharmacology and Therapeutics. 80, 3, p. 303-304 2 p.

Research output: Contribution to journalArticle

76 Citations

Verapamil P-glycoprotein transport across the rat blood-brain barrier: Cyclosporine, a concentration inhibition analysis, and comparison with human data

Hsiao, P., Sasongko, L., Link, J. M., Mankoff, D. A., Muzi, M., Collier, A. C. & Unadkat, J. D. May 2006 In : Journal of Pharmacology and Experimental Therapeutics. 317, 2, p. 704-710 7 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Verapamil
Blood-Brain Barrier
Cyclosporine
Radioactivity
2005
18 Citations

Cardiac receptor physiology and imaging: An update

Chen, G. P., Tabibiazar, R., Branch, K. R., Link, J. M. & Caldwell, J. H. Nov 2005 In : Journal of Nuclear Cardiology. 12, 6, p. 714-730 17 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Technology
Anatomy
Cardiovascular Diseases
Ischemia
137 Citations

Evaluation of 18F-annexin V as a PET imaging agent in an animal model of apoptosis

Yagle, K. J., Eary, J. F., Tait, J. F., Grierson, J. R., Link, J. M., Lewellen, B., Gibson, D. F. & Krohn, K. A. 2005 In : Journal of Nuclear Medicine. 46, 4, p. 658-666 9 p.

Research output: Contribution to journalArticle

Annexin A5
Animal Models
Apoptosis
In Situ Nick-End Labeling
Cycloheximide
209 Citations

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

Sasongko, L., Link, J. M., Muzi, M., Mankoff, D. A., Yang, X., Collier, A. C., Shoner, S. C. & Unadkat, J. D. Jun 2005 In : Clinical Pharmacology and Therapeutics. 77, 6, p. 503-514 12 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Blood-Brain Barrier
Human Activities
Positron-Emission Tomography
Area Under Curve
184 Citations

The progress and promise of molecular imaging probes in oncologic drug development

Kelloff, G. J., Krohn, K. A., Larson, S. M., Weissleder, R., Mankoff, D. A., Hoffman, J. M., Link, J. M., Guyton, K. Z., Eckelman, W. C., Scher, H. I., O'Shaughnessy, J., Cheson, B. D., Sigman, C. C., Tatum, J. L., Mills, G. Q., Sullivan, D. C. & Woodcock, J. Nov 15 2005 In : Clinical Cancer Research. 11, 22, p. 7967-7985 19 p.

Research output: Contribution to journalArticle

Molecular Probes
Molecular Imaging
Biomarkers
United States Food and Drug Administration
Pharmaceutical Preparations
73 Citations

True tracers: Comparing FDG with glucose and FLT with thymidine

Krohn, K. A., Mankoff, D. A., Muzi, M., Link, J. M. & Spence, A. M. Oct 2005 In : Nuclear Medicine and Biology. 32, 7, p. 663-671 9 p.

Research output: Contribution to journalArticle

Thymidine
Glucose
Fluorodeoxyglucose F18
Social Justice
Carbon Monoxide
2004
91 Citations

18F-FDG kinetics in locally advanced breast cancer: Correlation with tumor blood flow and changes in response to neoadjuvant chemotherapy

Tseng, J., Dunnwald, L. K., Schubert, E. K., Link, J. M., Minoshima, S., Muzi, M. & Mankoff, D. A. Nov 1 2004 In : Journal of Nuclear Medicine. 45, 11, p. 1829-1837 9 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Breast Neoplasms
Drug Therapy
Neoplasms
Glucose
123 Citations

18F-FDG PET of gliomas at delayed intervals: Improved distinction between tumor and normal gray matter

Spence, A. M., Muzi, M., Mankoff, D. A., O'Sullivan, S. F., Link, J. M., Lewellen, T. K., Lewellen, B., Pham, P., Minoshima, S., Swanson, K. & Krohn, K. A. Oct 1 2004 In : Journal of Nuclear Medicine. 45, 10, p. 1653-1659 7 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Glioma
Neoplasms
Brain
Gray Matter
56 Citations

Comparison of different quantitative approaches to18F-fluoride PET scans

Brenner, W., Vernon, C., Muzi, M., Mankoff, D. A., Link, J. M., Conrad, E. U. & Eary, J. F. Sep 1 2004 In : Journal of Nuclear Medicine. 45, 9, p. 1493-1500 8 p.

Research output: Contribution to journalArticle

Fluorides
Positron-Emission Tomography
Bone and Bones
Reference Values
Extremities