Jay Nelson

Research Professor, Director

  • 19482 Citations
  • 71 h-Index
1976 …2021

Research output per year

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Research Output

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Article
2018

Human cytomegalovirus encodes a novel FLT3 receptor ligand necessary for hematopoietic cell differentiation and viral reactivation

Crawford, L. B., Kim, J. H., Collins-McMillen, D., Lee, B. J., Landais, I., Held, C., Nelson, J., Yurochko, A. D. & Caposio, P., Mar 1 2018, In : mBio. 9, 2, e00682-18.

Research output: Contribution to journalArticle

10 Scopus citations

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch, A. J., Roberts, V. H. J., Grigsby, P. L., Haese, N., Schabel, M. C., Wang, X., Lo, J. O., Liu, Z., Kroenke, C. D., Smith, J. L., Kelleher, M., Broeckel, R., Kreklywich, C. N., Parkins, C. J., Denton, M., Smith, P., Defilippis, V., Messer, W., Nelson, J. A., Hennebold, J. D. & 12 others, Grafe, M., Colgin, L., Lewis, A., Ducore, R., Swanson, T., Legasse, A. W., Axthelm, M. K., MacAllister, R., Moses, A. V., Morgan, T. K., Frias, A. E. & Streblow, D. N., Dec 1 2018, In : Nature Communications. 9, 1, 263.

Research output: Contribution to journalArticle

50 Scopus citations
2017

Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice

Crawford, L. B., Tempel, R., Streblow, D., Kreklywich, C., Smith, P., Picker, L., Nelson, J. & Caposio, P., Dec 1 2017, In : Scientific Reports. 7, 1, 937.

Research output: Contribution to journalArticle

15 Scopus citations
21 Scopus citations

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Hirsch, A., Smith, J. L., Haese, N. N., Broeckel, R. M., Parkins, C. J., Kreklywich, C., De Filippis, V., Denton, M., Smith, P. P., Messer, W., Colgin, L., Ducore, R., Grigsby, P., Hennebold, J., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Wiley, C. A., Nelson, J. & 1 others, Streblow, D., Mar 1 2017, In : PLoS Pathogens. 13, 3, e1006219.

Research output: Contribution to journalArticle

110 Scopus citations
2016

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Hansen, S., Wu, H. L., Burwitz, B., Hughes, C. M., Hammond, K. B., Ventura, A. B., Reed, J. S., Gilbride, R. M., Ainslie, E., Morrow, D. W., Ford, J. C., Selseth, A. N., Pathak, R., Malouli, D., Legasse, A. W., Axthelm, M., Nelson, J., Gillespie, G. M., Walters, L. C., Brackenridge, S. & 8 others, Sharpe, H. R., López, C. A., Frueh, K., Korber, B. T., McMichael, A. J., Gnanakaran, S., Sacha, J. & Picker, L., Feb 12 2016, In : Science. 351, 6274, p. 714-720 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Complex interplay of the UL136 isoforms balances cytomegalovirus replication and Latency

Caviness, K., Bughio, F., Crawford, L. B., Streblow, D., Nelson, J., Caposio, P. & Goodrum, F., Mar 1 2016, In : mBio. 7, 2, e01986-15.

Research output: Contribution to journalArticle

20 Scopus citations

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

Burwitz, B., Malouli, D., Bimber, B. N., Reed, J. S., Ventura, A. B., Hancock, M., Uebelhoer, L. S., Bhusari, A., Hammond, K. B., Espinosa Trethewy, R. G., Klug, A., Legasse, A. W., Axthelm, M., Nelson, J., Park, B., Streblow, D., Hansen, S., Picker, L., Frueh, K. & Sacha, J., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1006014.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway

Landais, I., Pelton, C., Streblow, D., DeFilippis, V., McWeeney, S. & Nelson, J. A., May 1 2015, In : PLoS pathogens. 11, 5, e1004881.

Research output: Contribution to journalArticle

50 Scopus citations
2014

Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion

Hook, L. M., Grey, F., Grabski, R., Tirabassi, R., Doyle, T., Hancock, M., Landais, I., Jeng, S., McWeeney, S., Britt, W. & Nelson, J. A., Mar 12 2014, In : Cell Host and Microbe. 15, 3, p. 363-373 11 p.

Research output: Contribution to journalArticle

62 Scopus citations
18 Scopus citations

Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis

Macmaniman, J. D., Meuser, A., Botto, S., Smith, P. P., Liu, F., Jarvis, M. A., Nelson, J. A. & Caposio, P., Sep 26 2014, In : mBio. 5, 6, e02035-14.

Research output: Contribution to journalArticle

21 Scopus citations

Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis

MacManiman, J. D., Meuser, A., Botto, S., Smith, P. P., Liu, F., Jarvis, M. A., Nelson, J. A. & Caposio, P., 2014, In : mBio. 5, 6, p. e02035

Research output: Contribution to journalArticle

Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling

Smith, J. L., Stein, D. A., Shum, D., Fischer, M. A., Radu, C., Bhinder, B., Djaballah, H., Nelson, J. A., Früh, K. & Hirsch, A. J., 2014, In : Journal of virology. 88, 10, p. 5533-5542 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Techniques for characterizing cytomegalovirus-encoded miRNAs

Hook, L. M., Landais, I., Hancock, M. H. & Nelson, J. A., Jan 1 2014, In : Methods in Molecular Biology. 1119, p. 239-265 27 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transcriptome-wide discovery of microRNA binding sites in Human Brain

Boudreau, R. L., Jiang, P., Gilmore, B. L., Spengler, R. M., Tirabassi, R., Nelson, J. A., Ross, C. A., Xing, Y. & Davidson, B. L., Jan 22 2014, In : Neuron. 81, 2, p. 294-305 12 p.

Research output: Contribution to journalArticle

96 Scopus citations
2013

Flaviviruses are sensitive to inhibition of thymidine synthesis pathways

Fischer, M. A., Smith, J. L., Shum, D., Stein, D. A., Parkins, C., Bhinder, B., Radu, C., Hirsch, A. J., Djaballah, H., Nelson, J. A. & Früh, K., Sep 5 2013, In : Journal of virology. 87, 17, p. 9411-9419 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Immune clearance of highly pathogenic SIV infection

Hansen, S. G., Jr, M. P., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B. J., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M. K., Nelson, J. A., Früh, K. & 6 others, Sacha, J. B., Estes, J. D., Keele, B. F., Edlefsen, P. T., Lifson, J. D. & Picker, L. J., Jan 1 2013, In : Nature. 502, 7469, p. 100-104 5 p.

Research output: Contribution to journalArticle

351 Scopus citations
2012

Rhesus cytomegalovirus encodes seventeen microRNAs that are differentially expressed in vitro and in vivo

Hancock, M. H., Tirabassi, R. S. & Nelson, J. A., Apr 10 2012, In : Virology. 425, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection

Umashankar, M., Petrucelli, A., Cicchini, L., Caposio, P., Kreklywich, C. N., Rak, M., Bughio, F., Goldman, D. C., Hamlin, K. L., Nelson, J. A., Fleming, W. H., Streblow, D. N. & Goodrum, F., Dec 1 2011, In : PLoS pathogens. 7, 12, e1002444.

Research output: Contribution to journalArticle

75 Scopus citations

BST2/tetherin enhances entry of human cytomegalovirus

Viswanathan, K., Smith, M. S., Malouli, D., Mansouri, M., Nelson, J. A. & Früh, K., Nov 1 2011, In : PLoS pathogens. 7, 11, e1002332.

Research output: Contribution to journalArticle

38 Scopus citations

Human cytomegalovirus US7 is regulated synergistically by two virally encoded microRNAs and by two distinct mechanisms

Tirabassi, R., Hook, L., Landais, I., Grey, F., Meyers, H., Hewitt, H. & Nelson, J., Nov 1 2011, In : Journal of virology. 85, 22, p. 11938-11944 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence

Stein, D. A., Perry, S. T., Buck, M. D., Oehmen, C. S., Fischer, M. A., Poore, E., Smith, J. L., Lancaster, A. M., Hirsch, A. J., Slifka, M. K., Nelson, J. A., Shresta, S. & Früh, K., Oct 1 2011, In : Journal of virology. 85, 19, p. 10154-10166 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., Legasse, A. W., Chiuchiolo, M. J., Parks, C. L., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Piatak, M., Lifson, J. D. & Picker, L. J., May 26 2011, In : Nature. 473, 7348, p. 523-527 5 p.

Research output: Contribution to journalArticle

665 Scopus citations
2010

A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells

Wille, P. T., Knoche, A. J., Nelson, J. A., Jarvis, M. A. & Johnson, D. C., Mar 1 2010, In : Journal of virology. 84, 5, p. 2585-2596 12 p.

Research output: Contribution to journalArticle

91 Scopus citations

A viral microRNA down-regulates multiple cell cycle genes through mRNA 59′UTRs

Grey, F., Tirabassi, R., Meyers, H., Wu, G., McWeeney, S., Hook, L. & Nelson, J. A., Jun 1 2010, In : PLoS pathogens. 6, 6

Research output: Contribution to journalArticle

145 Scopus citations

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

Hansen, S. G., Powers, C. J., Richards, R., Ventura, A. B., Ford, J. C., Siess, D., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Picker, L. J. & Früh, K., Apr 2 2010, In : Science. 328, 5974, p. 102-106 5 p.

Research output: Contribution to journalArticle

171 Scopus citations

Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model

Smith, M. S., Goldman, D. C., Bailey, A. S., Pfaffle, D. L., Kreklywich, C. N., Spencer, D. B., Othieno, F. A., Streblow, D. N., Garcia, J. V., Fleming, W. H. & Nelson, J. A., Sep 16 2010, In : Cell Host and Microbe. 8, 3, p. 284-291 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

High-content assay to identify inhibitors of dengue virus infection

Shum, D., Smith, J. L., Hirsch, A. J., Bhinder, B., Radu, C., Stein, D. A., Nelson, J. A., Früh, K. & Djaballah, H., Oct 1 2010, In : Assay and Drug Development Technologies. 8, 5, p. 553-570 18 p.

Research output: Contribution to journalArticle

52 Scopus citations
2009

Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility

Vomaske, J., Melnychuk, R. M., Smith, P. P., Powell, J., Hall, L., DeFilippis, V., Früh, K., Smit, M., Schlaepfer, D. D., Nelson, J. A. & Streblow, D. N., Feb 1 2009, In : PLoS pathogens. 5, 2, e1000304.

Research output: Contribution to journalArticle

35 Scopus citations

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J. A., Jarvis, M. A. & Picker, L. J., Mar 1 2009, In : Nature medicine. 15, 3, p. 293-299 7 p.

Research output: Contribution to journalArticle

509 Scopus citations

Human cytomegalovirus US28: A functionally selective chemokine binding receptor

Vomaske, J., Nelson, J. A. & Streblow, D. N., Oct 5 2009, In : Infectious Disorders - Drug Targets. 9, 5, p. 548-556 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

p58IPK: A novel "CIHD" member of the host innate defense response against pathogenic virus infection

Goodman, A. G., Fornek, J. L., Medigeshi, G. R., Perrone, L. A., Peng, X., Dyer, M. D., Proll, S. C., Knoblaugh, S. E., Carter, V. S., Korth, M. J., Nelson, J. A., Tumpey, T. M. & Katze, M. G., May 1 2009, In : PLoS pathogens. 5, 5, e1000438.

Research output: Contribution to journalArticle

33 Scopus citations

Rat cytomegalovirus infection depletes MHC II in bone marrow derived dendritic cells

Baca Jones, C. C., Kreklywich, C. N., Messaoudi, I., Vomaske, J., McCartney, E., Orloff, S. L., Nelson, J. A. & Streblow, D. N., May 25 2009, In : Virology. 388, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function

Medigeshi, G. R., Hirsch, A. J., Brien, J. D., Uhrlaub, J. L., Mason, P. W., Wiley, C., Nikolich-Zugich, J. & Nelson, J. A., Jun 1 2009, In : Journal of virology. 83, 12, p. 6125-6134 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2008

Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells

Ryckman, B. J., Rainish, B. L., Chase, M. C., Borton, J. A., Nelson, J. A., Jarvis, M. A. & Johnson, D. C., Jan 1 2008, In : Journal of virology. 82, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

204 Scopus citations

Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing

Dumortier, J., Streblow, D. N., Moses, A. V., Jacobs, J. M., Kreklywich, C. N., Camp, D., Smith, R. D., Orloff, S. L. & Nelson, J. A., Jul 1 2008, In : Journal of virology. 82, 13, p. 6524-6535 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

Identification and function of human cytomegalovirus microRNAs

Grey, F. & Nelson, J., Mar 1 2008, In : Journal of Clinical Virology. 41, 3, p. 186-191 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants

Streblow, D. N., Kreklywich, C. N., Andoh, T., Moses, A. V., Dumortier, J., Smith, P. P., Defilippis, V., Fruh, K., Nelson, J. A. & Orloff, S. L., Feb 1 2008, In : American Journal of Transplantation. 8, 2, p. 277-287 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of αvβ3 integrin

Medigeshi, G. R., Hirsch, A. J., Streblow, D. N., Nikolich-Zugich, J. & Nelson, J. A., Jun 1 2008, In : Journal of virology. 82, 11, p. 5212-5219 8 p.

Research output: Contribution to journalArticle

94 Scopus citations
2007

A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication

Grey, F., Meyers, H., White, E. A., Spector, D. H. & Nelson, J., Nov 1 2007, In : PLoS pathogens. 3, 11, p. 1593-1602 10 p.

Research output: Contribution to journalArticle

190 Scopus citations

Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro

Streblow, D. N., Van Cleef, K. W. R., Kreklywich, C. N., Meyer, C., Smith, P., Defilippis, V., Grey, F., Früh, K., Searles, R., Bruggeman, C., Vink, C., Nelson, J. A. & Orloff, S. L., Apr 1 2007, In : Journal of virology. 81, 8, p. 3816-3826 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Small RNAs and large DNA viruses

Nelson, J. A., Dec 20 2007, In : New England Journal of Medicine. 357, 25, p. 2630-2632 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis

Medigeshi, G. R., Lancaster, A. M., Hirsch, A. J., Briese, T., Lipkin, W. I., DeFilippis, V., Früh, K., Mason, P. W., Nikolich-Zugich, J. & Nelson, J. A., Oct 1 2007, In : Journal of virology. 81, 20, p. 10849-10860 12 p.

Research output: Contribution to journalArticle

143 Scopus citations
2006

Human cytomegalovirus attenuates interleukin-1β and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-κB activation

Jarvis, M. A., Borton, J. A., Keech, A. M., Wong, J., Britt, W. J., Magun, B. E. & Nelson, J. A., Jun 1 2006, In : Journal of virology. 80, 11, p. 5588-5598 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion

Ryckman, B. J., Jarvis, M. A., Drummond, D. D., Nelson, J. A. & Johnson, D. C., Jan 1 2006, In : Journal of virology. 80, 2, p. 710-722 13 p.

Research output: Contribution to journalArticle

216 Scopus citations

Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection

DeFilippis, V. R., Robinson, B., Keck, T. M., Hansen, S. G., Nelson, J. A. & Früh, K. J., Jan 1 2006, In : Journal of virology. 80, 2, p. 1032-1037 6 p.

Research output: Contribution to journalArticle

50 Scopus citations
2005

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., Nelson, J. A. & Picker, L. J., Sep 5 2005, In : Journal of Experimental Medicine. 202, 5, p. 673-685 13 p.

Research output: Contribution to journalArticle

861 Scopus citations

Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL

Hegde, N. R., Dunn, C., Lewinsohn, D. M., Jarvis, M. A., Nelson, J. A. & Johnson, D. C., Oct 17 2005, In : Journal of Experimental Medicine. 202, 8, p. 1109-1119 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Identification and characterization of human cytomegalovirus-encoded microRNAs

Grey, F., Antoniewicz, A., Allen, E., Saugstad, J., McShea, A., Carrington, J. C. & Nelson, J., Sep 1 2005, In : Journal of virology. 79, 18, p. 12095-12099 5 p.

Research output: Contribution to journalArticle

215 Scopus citations