Jason Link

Research Assistant Professor

  • 531 Citations
  • 12 h-Index
20022019
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Research Output 2002 2019

  • 531 Citations
  • 12 h-Index
  • 20 Article
  • 2 Conference contribution
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Article
2019
6 Citations (Scopus)

A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., Vringer, E., Schug, M., Novo, D., Hwang, R. F., Evans, R. M., Nixon, C., Dorrell, C., Morton, J. P., Norman, J. C., Sears, R. & 2 others, Kamphorst, J. J. & Sherman, M., May 1 2019, In : Cancer discovery. 9, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Open Access
Adenocarcinoma
Neoplasms
Wound Healing
Lipids
Pancreatic Stellate Cells
2017
13 Citations (Scopus)

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Farrell, A., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L., Morton, J. P., Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D. & 5 others, Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. & Sears, R., Dec 1 2017, In : Nature Communications. 8, 1, 1728.

Research output: Contribution to journalArticle

Synaptophysin
plastic properties
markers
Plasticity
Tumors
2015
17 Citations (Scopus)

The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis

Link, J. & Hurlin, P. J., May 1 2015, In : Biochimica et Biophysica Acta - General Subjects. 1849, 5, p. 554-562 9 p.

Research output: Contribution to journalArticle

Lymphocytes
Carcinogenesis
Transcription
Genes
Proteins
2013
3 Citations (Scopus)

MYC needs MNT

Link, J. & Hurlin, P. J., Feb 1 2013, In : Cell Cycle. 12, 3, p. 385-386 2 p.

Research output: Contribution to journalArticle

2012
15 Citations (Scopus)

A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis

Link, J., Ota, S., Zhou, Z. Q., Daniel, C. J., Sears, R. & Hurlin, P. J., Nov 27 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19685-19690 6 p.

Research output: Contribution to journalArticle

Carcinogenesis
Cell Proliferation
T-Lymphocytes
Apoptosis
Embryonic Structures
2009
16 Citations (Scopus)

The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects

Ota, S., Zhou, Z. Q., Link, J. & Hurlin, P. J., 2009, In : Human Molecular Genetics. 18, 14, p. 2609-2621 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Neoplasms
Apoptosis
Morphogenesis
DNA Damage
2008

Erratum to "αB-Crystallin-reactive T cells from knockout mice are not encephalitogenic" [J. Neuroimmunol. 176 (2006) 51-62] (DOI: 10.1016/j.jneuroim.2006.04.010)

Wang, C., Chou, Y. K., Rich, C. M., Link, J., Afentoulis, M. E., van Noort, J. M., Wawrousek, E. F., Offner, H. & Vandenbark, A., Dec 15 2008, In : Journal of Neuroimmunology. 205, 1-2, p. 162 1 p.

Research output: Contribution to journalArticle

Crystallins
Knockout Mice
T-Lymphocytes
2007
16 Citations (Scopus)

Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice

Link, J., Rich, C. M., Korat, M., Burrows, G. G., Offner, H. & Vandenbark, A., Apr 2007, In : Clinical Immunology. 123, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

Encephalomyelitis
Autoimmune Experimental Encephalomyelitis
Transgenic Mice
HLA-DR2 Antigen
Ligands
2006
11 Citations (Scopus)

αB-Crystallin-reactive T cells from knockout mice are not encephalitogenic

Wang, C., Chou, Y. K., Rich, C. M., Link, J., Afentoulis, M. E., van Noort, J. M., Wawrousek, E. F., Offner, H. & Vandenbark, A., Jul 2006, In : Journal of Neuroimmunology. 176, 1-2, p. 51-62 12 p.

Research output: Contribution to journalArticle

Crystallins
Knockout Mice
T-Lymphocytes
Autoimmune Experimental Encephalomyelitis
Immune Tolerance
2005
10 Citations (Scopus)

Adult lupus-prone MRL/MpJ2+ mice express a primary antibody repertoire that differs in CDR-H3 length distribution and hydrophobicity from that expressed in the C3H parental strain

Zemlin, M., Ippolito, G. C., Zemlin, C., Link, J., Monestier, M. & Schroeder, H. W., May 2005, In : Molecular Immunology. 42, 7, p. 789-798 10 p.

Research output: Contribution to journalArticle

Hydrophobic and Hydrophilic Interactions
Complementarity Determining Regions
Amino Acids
B-Lymphoid Precursor Cells
Antibodies
17 Citations (Scopus)

Despite extensive similarity in germline DH and JH sequence, the adult Rhesus macaque CDR-H3 repertoire differs from human

Link, J., Larson, J. E. & Schroeder, H. W., May 2005, In : Molecular Immunology. 42, 8, p. 943-955 13 p.

Research output: Contribution to journalArticle

Macaca mulatta
Pan troglodytes
Immunoglobulins
Complementarity Determining Regions
Immunoglobulin Heavy Chains
26 Citations (Scopus)

Identification of HLA-DRB1*1501-restricted T-cell epitopes from prostate-specific antigen

Klyushnenkova, E. N., Link, J., Oberle, W. T., Kodak, J., Rich, C., Vandenbark, A. & Alexander, R. B., Apr 15 2005, In : Clinical Cancer Research. 11, 8, p. 2853-2861 9 p.

Research output: Contribution to journalArticle

HLA-DRB1 Chains
T-Lymphocyte Epitopes
Prostate-Specific Antigen
Peptides
Prostate
10 Citations (Scopus)

Rationally designed mutations convert complexes of human recombinant T cell receptor ligands into monomers that retain biological activity

Huan, J., Meza-Romero, R., Mooney, J. L., Chou, Y. K., Edwards, D. M., Rich, C., Link, J., Vandenbark, A., Bourdette, D., Bächinger, H. P. & Burrows, G. G., Jan 2005, In : Journal of Chemical Technology and Biotechnology. 80, 1, p. 2-12 11 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
Bioactivity
peptide
Peptides
2004
11 Citations (Scopus)

HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes

Finn, T. P., Jones, R. E., Rich, C., Dahan, R., Link, J., David, C. S., Chou, Y. K., Offner, H. & Vandenbark, A., Oct 1 2004, In : Journal of Neuroscience Research. 78, 1, p. 100-114 15 p.

Research output: Contribution to journalArticle

Myelin Sheath
HLA Antigens
Multiple Sclerosis
Epitopes
Peptides
42 Citations (Scopus)

Monomeric Recombinant TCR Ligand Reduces Relapse Rate and Severity of Experimental Autoimmune Encephalomyelitis in SJL/J Mice through Cytokine Switch

Huan, J., Subramanian, S., Jones, R., Rich, C., Link, J., Mooney, J., Bourdette, D., Vandenbark, A., Burrows, G. G. & Offner, H., Apr 1 2004, In : Journal of Immunology. 172, 7, p. 4556-4566 11 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Cytokines
Ligands
Recurrence
Peptides
43 Citations (Scopus)

Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice

Rich, C., Link, J., Zamora, A., Jacobsen, H., Meza-Romero, R., Offner, H., Jones, R., Burrows, G. G., Fugger, L. & Vandenbark, A., May 2004, In : European Journal of Immunology. 34, 5, p. 1251-1261 11 p.

Research output: Contribution to journalArticle

HLA-DR2 Antigen
Autoimmune Experimental Encephalomyelitis
Transgenic Mice
Peptides
Multiple Sclerosis
13 Citations (Scopus)

T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice

Chou, Y. K., Culbertson, N., Rich, C., LaTocha, D., Buenafe, A. C., Huan, J., Link, J., Wands, J. M., Born, W. K., Offner, H., Bourdette, D., Burrows, G. G. & Vandenbark, A., Sep 1 2004, In : Journal of Neuroscience Research. 77, 5, p. 670-680 11 p.

Research output: Contribution to journalArticle

HLA-DRB1 Chains
Hybridomas
Transgenic Mice
T-Lymphocytes
Peptides
2003
215 Citations (Scopus)

Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures

Zemlin, M., Klinger, M., Link, J., Zemlin, C., Bauer, K., Engler, J. A., Schroeder, H. W. & Kirkham, P. M., Dec 5 2003, In : Journal of Molecular Biology. 334, 4, p. 733-749 17 p.

Research output: Contribution to journalArticle

Amino Acids
Tyrosine
Complementarity Determining Regions
Proline
Glycine
2002
10 Citations (Scopus)

Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes

Link, J. & Schroeder, H. W., 2002, In : Arthritis Research. 4, 2, p. 80-83 4 p.

Research output: Contribution to journalArticle

Immunoglobulin Genes
Autoantibodies
Autoimmune Diseases
Antibodies
Autoantigens
24 Citations (Scopus)

The Rhesus monkey immunoglobulin IGHD and IGHJ germline repertoire

Link, J., Hellinger, M. A. & Schroeder, H. W., 2002, In : Immunogenetics. 54, 4, p. 240-250 11 p.

Research output: Contribution to journalArticle

Macaca mulatta
Immunoglobulins
Genes
Protein Sorting Signals
Genetic Recombination