Janet Douglas

Research Assistant Professor

  • 1628 Citations
  • 22 h-Index
19912015
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Research Output 1991 2015

  • 1628 Citations
  • 22 h-Index
  • 36 Article
  • 1 Chapter
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Article
2015
17 Citations (Scopus)
Ebolavirus
Glycoproteins
Virion
Down-Regulation
Human Immunodeficiency Virus Proteins
2013
7 Citations (Scopus)
HIV-1
Down-Regulation
3 Citations (Scopus)

BST-2/tetherin: Viral tether, viral sensor or both?

Gustin, J. & Douglas, J., Nov 2013, In : Future Virology. 8, 11, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

Virion
Virus Release
Virology
Innate Immunity
Cell Survival
2012
29 Citations (Scopus)
Bearings (structural)
Human Immunodeficiency Virus Proteins
Ubiquitination
Threonine
Serine
2011
29 Citations (Scopus)

Viral takeover of the host ubiquitin system

Gustin, J., Moses, A., Frueh, K. & Douglas, J., 2011, In : Frontiers in Microbiology. 2, JULY

Research output: Contribution to journalArticle

Ubiquitin
Viruses
DNA Viruses
Ubiquitination
DNA Tumor Viruses
2010
37 Citations (Scopus)

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

Mackman, R. L., Ray, A. S., Hui, H. C., Zhang, L., Birkus, G., Boojamra, C. G., Desai, M. C., Douglas, J., Gao, Y., Grant, D., Laflamme, G., Lin, K. Y., Markevitch, D. Y., Mishra, R., McDermott, M., Pakdaman, R., Petrakovsky, O. V., Vela, J. E. & Cihlar, T., May 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 10, p. 3606-3617 12 p.

Research output: Contribution to journalArticle

HIV Reverse Transcriptase
Organophosphonates
Reverse Transcriptase Inhibitors
Prodrugs
Nucleosides
16 Citations (Scopus)

Kaposi sarcoma pathogenesis: A triad of viral infection, oncogenesis and chronic inflammation

Douglas, J., Gustin, J., Moses, A., Dezube, B. J. & Pantanowitz, L., 2010, In : Translational Biomedicine. 1, 2, 2.

Research output: Contribution to journalArticle

Kaposi's Sarcoma
Virus Diseases
Carcinogenesis
Human Herpesvirus 8
Inflammation
90 Citations (Scopus)

The great escape: Viral strategies to counter BST-2/ tetherin

Douglas, J., Gustin, J., Viswanathan, K., Mansouri, M., Moses, A. & Frueh, K., May 2010, In : PLoS Pathogens. 6, 5, p. 1-12 12 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Viruses
Virion
HIV-1
Ebolavirus
2009
5 Citations (Scopus)

Characterization of c-Kit expression and activation in KSHV-infected endothelial cells

Douglas, J., Whitford, J. G. & Moses, A., Aug 1 2009, In : Virology. 390, 2, p. 174-185 12 p.

Research output: Contribution to journalArticle

Herpesviridae
Kaposi's Sarcoma
Proto-Oncogene Proteins c-kit
Endothelial Cells
Stem Cell Factor
192 Citations (Scopus)

Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus

Mansouri, M., Viswanathan, K., Douglas, J., Hines, J., Gustin, J., Moses, A. & Frueh, K., Oct 2009, In : Journal of Virology. 83, 19, p. 9672-9681 10 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Human Herpesvirus 8
ubiquitin
immunomodulators
transmembrane proteins
254 Citations (Scopus)

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/tetherin via a βTrCP-dependent mechanism

Douglas, J., Viswanathan, K., McCarroll, M. N., Gustin, J., Frueh, K. & Moses, A., Aug 2009, In : Journal of Virology. 83, 16, p. 7931-7947 17 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus
Down-Regulation
HIV
degradation
Virion
2008
66 Citations (Scopus)

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131

Cihlar, T., Ray, A. S., Boojamra, C. G., Zhang, L., Hui, H., Laflamme, G., Vela, J. E., Grant, D., Chen, J., Myrick, F., White, K. L., Gao, Y., Lin, K. Y., Douglas, J., Parkin, N. T., Carey, A., Pakdaman, R. & Mackman, R. L., Feb 2008, In : Antimicrobial Agents and Chemotherapy. 52, 2, p. 655-665 11 p.

Research output: Contribution to journalArticle

Prodrugs
Nucleosides
HIV-1
Nucleotides
Reverse Transcriptase Inhibitors
24 Citations (Scopus)

Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148

Mackman, R. L., Lin, K. Y., Boojamra, C. G., Hui, H., Douglas, J., Grant, D., Petrakovsky, O., Prasad, V., Ray, A. S. & Cihlar, T., Feb 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 3, p. 1116-1119 4 p.

Research output: Contribution to journalArticle

Organophosphonates
HIV-2
Fluorine
Guanosine
Nucleosides
50 Citations (Scopus)

Synthesis and anti-HIV activity of GS-9148 (2′-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor

Boojamra, C. G., Mackman, R. L., Markevitch, D. Y., Prasad, V., Ray, A. S., Douglas, J., Grant, D., Kim, C. U. & Cihlar, T., Feb 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 3, p. 1120-1123 4 p.

Research output: Contribution to journalArticle

HIV Reverse Transcriptase
Organophosphonates
Reverse Transcriptase Inhibitors
Nucleosides
HIV
2007
51 Citations (Scopus)

Kaposi's sarcoma: A model of both malignancy and chronic inflammation

Douglas, J., Gustin, J., Dezube, B. J., Pantanowitz, L. & Moses, A., Sep 2007, In : Panminerva Medica. 49, 3, p. 119-138 20 p.

Research output: Contribution to journalArticle

Kaposi's Sarcoma
Inflammation
Human Herpesvirus 8
Neoplasms
Endothelial Cells
25 Citations (Scopus)

Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs

Mackman, R. L., Zhang, L., Prasad, V., Boojamra, C. G., Douglas, J., Grant, D., Hui, H., Kim, C. U., Laflamme, G., Parrish, J., Stoycheva, A. D., Swaminathan, S., Wang, K. & Cihlar, T., Aug 15 2007, In : Bioorganic and Medicinal Chemistry. 15, 16, p. 5519-5528 10 p.

Research output: Contribution to journalArticle

Prodrugs
Nucleosides
Thymidine
HIV
Tenofovir
28 Citations (Scopus)

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates

Mackman, R. L., Boojamra, C. G., Prasad, V., Zhang, L., Lin, K. Y., Petrakovsky, O., Babusis, D., Chen, J., Douglas, J., Grant, D., Hui, H. C., Kim, C. U., Markevitch, D. Y., Vela, J., Ray, A. & Cihlar, T., Dec 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 24, p. 6785-6789 5 p.

Research output: Contribution to journalArticle

Organophosphonates
Reverse Transcriptase Inhibitors
Ribose
RNA-Directed DNA Polymerase
Nucleosides
13 Citations (Scopus)

Synthesis and anti-HIV activity of cyclic pyrimidine phosphonomethoxy nucleosides and their prodrugs: A comparison of phosphonates and corresponding nucleosides

Mackman, R. L., Zhang, L., Prasad, V., Boojamra, C. G., Chen, J., Douglas, J., Grant, D., Laflamme, G., Hui, H., Kim, C. U., Parrish, J., Stoycheva, A. D., Swaminathan, S., Wang, K. & Cihlar, T., Jun 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 6-7, p. 573-577 5 p.

Research output: Contribution to journalArticle

Pyrimidine Nucleosides
HIV Reverse Transcriptase
Organophosphonates
Reverse Transcriptase Inhibitors
RNA-Directed DNA Polymerase
2006
65 Citations (Scopus)

Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells

Mansouri, M., Douglas, J., Rose, P. P., Gouveia, K., Thomas, G., Means, R. E., Moses, A. & Frueh, K., Sep 15 2006, In : Blood. 108, 6, p. 1932-1940 9 p.

Research output: Contribution to journalArticle

Kaposi's Sarcoma
Herpesviridae
Endothelial cells
Cell Adhesion Molecules
Platelets
2005
79 Citations (Scopus)

Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms

Douglas, J., Panis, M. L., Ho, E., Lin, K. Y., Krawczyk, S. H., Grant, D. M., Cai, R., Swaminathan, S., Chen, X. & Cihlar, T., Jun 2005, In : Antimicrobial Agents and Chemotherapy. 49, 6, p. 2460-2466 7 p.

Research output: Contribution to journalArticle

2((2-((1-(2-aminoethyl)-4-piperidinyl)amino)-4-methyl-1H-benzimidazol-1-yl)methyl)-6-methyl-3-pyridinol
Respiratory Syncytial Viruses
Mutation
Proteins
Peptide T
2004
20 Citations (Scopus)

In search of a small-molecule inhibitor for respiratory syncytial virus

Douglas, J., Aug 2004, In : Expert Review of Anti-Infective Therapy. 2, 4, p. 625-639 15 p.

Research output: Contribution to journalArticle

Respiratory Syncytial Viruses
Antiviral Agents
Hospitalization
Vaccines
Viruses
2003
91 Citations (Scopus)

Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein

Douglas, J., Panis, M. L., Ho, E., Lin, K. Y., Krawczyk, S. H., Grant, D. M., Cai, R., Swaminathan, S. & Cihlar, T., May 2003, In : Journal of Virology. 77, 9, p. 5054-5064 11 p.

Research output: Contribution to journalArticle

Respiratory Syncytial Viruses
viruses
Proteins
proteins
mutation
2001
18 Citations (Scopus)
Lymphopoiesis
Hematopoietic Stem Cells
Blood Cells
HIV
T-Lymphocytes
2000
14 Citations (Scopus)

In vitro selection of lentivirus vector-transduced human CD34+ cells

Gatlin, J., Douglas, J., Evans, J. T., Collins, R. H., Wendel, G. D. & Garcia, J. V., Sep 1 2000, In : Human Gene Therapy. 11, 13, p. 1949-1957 9 p.

Research output: Contribution to journalArticle

Lentivirus
Genes
In Vitro Techniques
Fetal Blood
Stem Cells
42 Citations (Scopus)

Lentivirus-based vectors transduce mouse hematopoietic stem cells with similar efficiency to Moloney murine leukemia virus-based vectors

Barrette, S., Douglas, J., Seidel, N. E. & Bodine, D. M., Nov 15 2000, In : Blood. 96, 10, p. 3385-3391 7 p.

Research output: Contribution to journalArticle

Moloney murine leukemia virus
Lentivirus
Hematopoietic Stem Cells
Stem cells
Viruses
33 Citations (Scopus)

Superior Transduction of Mouse Hematopoietic Stem Cells with 10A1 and VSV-G Pseudotyped Retrovirus Vectors

Barrette, S., Douglas, J., Orlic, D., Anderson, S. M., Seidel, N. E., Miller, A. D. & Bodine, D. M., Apr 2000, In : Molecular Therapy. 1, 4, p. 330-338 9 p.

Research output: Contribution to journalArticle

Retroviridae
Hematopoietic Stem Cells
Gibbon ape leukemia virus
Messenger RNA
Viruses
1999
53 Citations (Scopus)

Efficient transduction of human lymphocytes and CD34+ cells via human immunodeficiency virus-based gene transfer vectors

Douglas, J., Kelly, P., Evans, J. T. & Garcia, J. V., Apr 10 1999, In : Human Gene Therapy. 10, 6, p. 935-945 11 p.

Research output: Contribution to journalArticle

HIV
Lymphocytes
Genes
Genetic Therapy
Flow Cytometry
1998
68 Citations (Scopus)

Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: Implications for HIV-based gene transfer systems

Luo, T., Douglas, J., Livingston, R. L. & Garcia, J. V., Feb 15 1998, In : Virology. 241, 2, p. 224-233 10 p.

Research output: Contribution to journalArticle

Virus Internalization
HIV-1
HIV
Vesicular Stomatitis
Genes
1997
12 Citations (Scopus)

Immortalization of primary epithelial cells by E1A 12S requires late, second exon-encoded functions in addition to complex formation with pRB and p300

Gopalakrishnan, S., Douglas, J. & Quinlan, M. P., May 1997, In : Cell Growth and Differentiation. 8, 5, p. 541-551 11 p.

Research output: Contribution to journalArticle

Exons
Epithelial Cells
Cell Cycle
Tumor Suppressor Protein p53
Cell Aging
18 Citations (Scopus)
Human herpesvirus 8
Human Herpesvirus 8
body cavities
Butyrates
Kaposi's Sarcoma
63 Citations (Scopus)

The amphotropic murine leukemia virus receptor gene encodes a 71- kilodalton protein that is induced by phosphate depletion

Chien, M. L., Foster, J. L., Douglas, J. & Garcia, J. V., Jun 1997, In : Journal of Virology. 71, 6, p. 4564-4570 7 p.

Research output: Contribution to journalArticle

Type III Sodium-Phosphate Cotransporter Proteins
Murine leukemia virus
Phosphates
phosphates
Messenger RNA
1996
7 Citations (Scopus)

Structural limitations of the Ad5 E1A 12S nuclear localization signal

Douglas, J. & Quinlan, M. P., Jun 15 1996, In : Virology. 220, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Polyomavirus Transforming Antigens
Oncogene Proteins
Viral Tumor Antigens
Amino Acids
1995
20 Citations (Scopus)
Adenoviridae
exons
Exons
Nuclear Localization Signals
nuclear localization signals
1994
18 Citations (Scopus)
Exons
Nuclear Localization Signals
Epithelial Cells
Proteins
Cell Proliferation
1992
31 Citations (Scopus)

Immortalization of primary epithelial cells requires first- and second-exon functions of adenovirus type 5 12S

Quinlan, M. P. & Douglas, J., Apr 1992, In : Journal of Virology. 66, 4, p. 2020-2030 11 p.

Research output: Contribution to journalArticle

Adenoviridae
exons
Exons
epithelial cells
Epithelial Cells
1991
40 Citations (Scopus)

Modulation of transformation of primary epithelial cells by the second exon of the Ad5 E1A12S gene

Douglas, J., Gopalakrishnan, S. & Quinlan, M. P., Nov 1991, In : Oncogene. 6, 11, p. 2093-2103 11 p.

Research output: Contribution to journalArticle

Exons
Epithelial Cells
Genes
Phenotype
Nuclear Localization Signals