Janet Douglas

Research Assistant Professor

  • 1657 Citations
  • 22 h-Index
19912015

Research output per year

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Research Output

  • 1657 Citations
  • 22 h-Index
  • 32 Article
  • 4 Review article
  • 1 Chapter
2015
18 Scopus citations
2013
7 Scopus citations

BST-2/tetherin: Viral tether, viral sensor or both?

Gustin, J. K. & Douglas, J. L., Nov 1 2013, In : Future Virology. 8, 11, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012
30 Scopus citations
2011

Viral takeover of the host ubiquitin system

Gustin, J. K., Moses, A. V., Früh, K. & Douglas, J. L., Jan 1 2011, In : Frontiers in Microbiology. 2, JULY

Research output: Contribution to journalReview article

31 Scopus citations
2010

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

Mackman, R. L., Ray, A. S., Hui, H. C., Zhang, L., Birkus, G., Boojamra, C. G., Desai, M. C., Douglas, J. L., Gao, Y., Grant, D., Laflamme, G., Lin, K. Y., Markevitch, D. Y., Mishra, R., McDermott, M., Pakdaman, R., Petrakovsky, O. V., Vela, J. E. & Cihlar, T., May 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 10, p. 3606-3617 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Kaposi sarcoma pathogenesis: A triad of viral infection, oncogenesis and chronic inflammation

Douglas, J. L., Gustin, J. K., Moses, A. V., Dezube, B. J. & Pantanowitz, L., 2010, In : Translational Biomedicine. 1, 2, 2.

Research output: Contribution to journalArticle

18 Scopus citations

Targeting signal transduction pathways for the treatment of Kaposi sarcoma

Douglas, J. L., Koon, H. B. & Moses, A. V., Dec 1 2010, Molecular Basis for Therapy of AIDS-Defining Cancers. Springer New York, p. 79-93 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The great escape: Viral strategies to counter BST-2/ tetherin

Douglas, J. L., Gustin, J. K., Viswanathan, K., Mansouri, M., Moses, A. V. & Früh, K., May 1 2010, In : PLoS pathogens. 6, 5, p. 1-12 12 p.

Research output: Contribution to journalReview article

94 Scopus citations
2009

Characterization of c-Kit expression and activation in KSHV-infected endothelial cells

Douglas, J. L., Whitford, J. G. & Moses, A. V., Aug 1 2009, In : Virology. 390, 2, p. 174-185 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus

Mansouri, M., Viswanathan, K., Douglas, J. L., Hines, J., Gustin, J., Moses, A. V. & Früh, K., Oct 1 2009, In : Journal of virology. 83, 19, p. 9672-9681 10 p.

Research output: Contribution to journalArticle

194 Scopus citations

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/tetherin via a βTrCP-dependent mechanism

Douglas, J. L., Viswanathan, K., McCarroll, M. N., Gustin, J. K., Früh, K. & Moses, A. V., Aug 1 2009, In : Journal of virology. 83, 16, p. 7931-7947 17 p.

Research output: Contribution to journalArticle

259 Scopus citations
2008

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131

Cihlar, T., Ray, A. S., Boojamra, C. G., Zhang, L., Hui, H., Laflamme, G., Vela, J. E., Grant, D., Chen, J., Myrick, F., White, K. L., Gao, Y., Lin, K. Y., Douglas, J. L., Parkin, N. T., Carey, A., Pakdaman, R. & Mackman, R. L., Feb 1 2008, In : Antimicrobial agents and chemotherapy. 52, 2, p. 655-665 11 p.

Research output: Contribution to journalArticle

67 Scopus citations

Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148

Mackman, R. L., Lin, K. Y., Boojamra, C. G., Hui, H., Douglas, J., Grant, D., Petrakovsky, O., Prasad, V., Ray, A. S. & Cihlar, T., Feb 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 3, p. 1116-1119 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Synthesis and anti-HIV activity of GS-9148 (2′-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor

Boojamra, C. G., Mackman, R. L., Markevitch, D. Y., Prasad, V., Ray, A. S., Douglas, J., Grant, D., Kim, C. U. & Cihlar, T., Feb 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 3, p. 1120-1123 4 p.

Research output: Contribution to journalArticle

50 Scopus citations
2007

Kaposi's sarcoma: A model of both malignancy and chronic inflammation

Douglas, J. L., Gustin, J. K., Dezube, B. J., Pantanowitz, L. & Moses, A. V., Sep 1 2007, In : Panminerva Medica. 49, 3, p. 119-138 20 p.

Research output: Contribution to journalReview article

51 Scopus citations

Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs

Mackman, R. L., Zhang, L., Prasad, V., Boojamra, C. G., Douglas, J., Grant, D., Hui, H., Kim, C. U., Laflamme, G., Parrish, J., Stoycheva, A. D., Swaminathan, S., Wang, K. Y. & Cihlar, T., Aug 15 2007, In : Bioorganic and Medicinal Chemistry. 15, 16, p. 5519-5528 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates

Mackman, R. L., Boojamra, C. G., Prasad, V., Zhang, L., Lin, K. Y., Petrakovsky, O., Babusis, D., Chen, J., Douglas, J., Grant, D., Hui, H. C., Kim, C. U., Markevitch, D. Y., Vela, J., Ray, A. & Cihlar, T., Dec 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 24, p. 6785-6789 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Synthesis and anti-HIV activity of cyclic pyrimidine phosphonomethoxy nucleosides and their prodrugs: A comparison of phosphonates and corresponding nucleosides

Mackman, R. L., Zhang, L., Prasad, V., Boojamra, C. G., Chen, J., Douglas, J., Grant, D., Laflamme, G., Hui, H., Kim, C. U., Parrish, J., Stoycheva, A. D., Swaminathan, S., Wang, K. Y. & Cihlar, T., Jun 1 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 6-7, p. 573-577 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2006

Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells

Mansouri, M., Douglas, J., Rose, P. P., Gouveia, K., Thomas, G., Means, R. E., Moses, A. V. & Früh, K., Sep 15 2006, In : Blood. 108, 6, p. 1932-1940 9 p.

Research output: Contribution to journalArticle

67 Scopus citations
2005

Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms

Douglas, J. L., Panis, M. L., Ho, E., Lin, K. Y., Krawczyk, S. H., Grant, D. M., Cai, R., Swaminathan, S., Chen, X. & Cihlar, T., Jun 1 2005, In : Antimicrobial agents and chemotherapy. 49, 6, p. 2460-2466 7 p.

Research output: Contribution to journalArticle

80 Scopus citations
2004

In search of a small-molecule inhibitor for respiratory syncytial virus

Douglas, J. L., Aug 2004, In : Expert Review of Anti-Infective Therapy. 2, 4, p. 625-639 15 p.

Research output: Contribution to journalReview article

20 Scopus citations
2003

Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein

Douglas, J. L., Panis, M. L., Ho, E., Lin, K. Y., Krawczyk, S. H., Grant, D. M., Cai, R., Swaminathan, S. & Cihlar, T., May 1 2003, In : Journal of virology. 77, 9, p. 5054-5064 11 p.

Research output: Contribution to journalArticle

93 Scopus citations
2001
18 Scopus citations
2000

In vitro selection of lentivirus vector-transduced human CD34+ cells

Gatlin, J., Douglas, J., Evans, J. T., Collins, R. H., Wendel, G. D. & Garcia, J. V., Sep 1 2000, In : Human Gene Therapy. 11, 13, p. 1949-1957 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lentivirus-based vectors transduce mouse hematopoietic stem cells with similar efficiency to Moloney murine leukemia virus-based vectors

Barrette, S., Douglas, J. L., Seidel, N. E. & Bodine, D. M., Nov 15 2000, In : Blood. 96, 10, p. 3385-3391 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Superior Transduction of Mouse Hematopoietic Stem Cells with 10A1 and VSV-G Pseudotyped Retrovirus Vectors

Barrette, S., Douglas, J., Orlic, D., Anderson, S. M., Seidel, N. E., Miller, A. D. & Bodine, D. M., Apr 1 2000, In : Molecular Therapy. 1, 4, p. 330-338 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
1999

Efficient transduction of human lymphocytes and CD34+ cells via human immunodeficiency virus-based gene transfer vectors

Douglas, J., Kelly, P., Evans, J. T. & Garcia, J. V., Apr 10 1999, In : Human Gene Therapy. 10, 6, p. 935-945 11 p.

Research output: Contribution to journalArticle

53 Scopus citations
1998

Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: Implications for HIV-based gene transfer systems

Luo, T., Douglas, J. L., Livingston, R. L. & Garcia, J. V., Feb 15 1998, In : Virology. 241, 2, p. 224-233 10 p.

Research output: Contribution to journalArticle

69 Scopus citations
1997

Immortalization of primary epithelial cells by E1A 12S requires late, second exon-encoded functions in addition to complex formation with pRB and p300

Gopalakrishnan, S., Douglas, J. L. & Quinlan, M. P., May 1 1997, In : Cell Growth and Differentiation. 8, 5, p. 541-551 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
18 Scopus citations

The amphotropic murine leukemia virus receptor gene encodes a 71- kilodalton protein that is induced by phosphate depletion

Chien, M. L., Foster, J. L., Douglas, J. L. & Garcia, J. V., Jun 1 1997, In : Journal of virology. 71, 6, p. 4564-4570 7 p.

Research output: Contribution to journalArticle

65 Scopus citations
1996

Structural limitations of the Ad5 E1A 12S nuclear localization signal

Douglas, J. L. & Quinlan, M. P., Jun 15 1996, In : Virology. 220, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
1995
21 Scopus citations
1994
18 Scopus citations
1992

Immortalization of primary epithelial cells requires first- and second- exon functions of adenovirus type 5 12S

Quinlan, M. P. & Douglas, J. L., Jan 1 1992, In : Journal of virology. 66, 4, p. 2020-2030 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
1991

Modulation of transformation of primary epithelial cells by the second exon of the Ad5 E1A12S gene

Douglas, J. L., Gopalakrishnan, S. & Quinlan, M. P., Nov 29 1991, In : Oncogene. 6, 11, p. 2093-2103 11 p.

Research output: Contribution to journalArticle

40 Scopus citations