James (Jim) Rosenbaum

Professor

  • 17990 Citations
  • 67 h-Index
1974 …2021
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Research Output 1974 2020

2009
44 Citations (Scopus)

Hypothesis: Sarcoidosis is a STAT1-mediated disease

Rosenbaum, J. J., Pasadhika, S., Crouser, E. D., Choi, D., Harrington, C. C., Lewis, J. A., Austin, C. R., Diebel, T. N., Vance, E. E., Braziel, R., Smith, J. R. & Planck, S., Aug 2009, In : Clinical Immunology. 132, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

Sarcoidosis
Lymph Nodes
Interferons
Lung
Hypercalcemia
28 Citations (Scopus)

Immunoregulation on the ocular surface: 2nd cullen symposium

Pflugfelder, S. C., Stern, M. E., Beutler, B. A., Burns, A. R., Calonge, M., Chodosh, J., Dana, M. R., De Paiva, C. S., Fleiszig, S., Hazlett, L. D., Huang, A. J., Jones, D. B., Liu, Y. J., McDermott, A. M., Mircheff, A. K., Niederkorn, J. Y., Perez, V., Perlman, E., Rosenbaum, J. J., Theofilopoulus, A. & 1 others, Wilhelmu, K., 2009, In : Ocular Surface. 7, 2, p. 67-77 11 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Cornea
Immune System
Catalytic Domain

Inflammatory eye disease

Rosenbaum, J. J. & Papaliodis, G. N., 2009, A Clinician's Pearls and Myths in Rheumatology. Springer London, p. 377-384 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eye Diseases
Anterior Uveitis
Orbital Pseudotumor
Posterior Uveitis
Iritis
97 Citations (Scopus)

Infliximab therapy for refractory uveitis: 2-Year results of a prospective trial

Suhler, E. B., Smith, J. R., Giles, T. R., Lauer, A. K., Wertheim, M. S., Kurz, D. E., Kurz, P. A., Lim, L., Mackensen, F., Pickard, T. D. & Rosenbaum, J. T., Jun 2009, In : Archives of Ophthalmology. 127, 6, p. 819-822 4 p.

Research output: Contribution to journalArticle

Uveitis
Intravenous Infusions
Young Adult
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
27 Citations (Scopus)

Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles

Sharma, S. M., Choi, D., Planck, S., Harrington, C. C., Austin, C. R., Lewis, J. A., Diebel, T. N., Martin, T., Smith, J. R. & Rosenbaum, J. J., Nov 9 2009, In : Arthritis Research and Therapy. 11, 6, R168.

Research output: Contribution to journalArticle

Spondylarthropathies
Transcriptome
Secretory Leukocyte Peptidase Inhibitor
Interleukin-1 Receptors
Bone Remodeling
23 Citations (Scopus)

Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice

Zhang, Z., Zhong, W., Spencer, D., Chen, H., Lu, H., Kawaguchi, T. & Rosenbaum, J. J., Apr 2009, In : Cytokine. 46, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

Interleukin-17
Uveitis
Ovalbumin
Neutrophils
Inflammation
172 Citations (Scopus)

Methotrexate for Ocular Inflammatory Diseases

Gangaputra, S., Newcomb, C. W., Liesegang, T. L., Kaçmaz, R. O., Jabs, D. A., Levy-Clarke, G. A., Nussenblatt, R. B., Rosenbaum, J. J., Suhler, E., Thorne, J. E., Foster, C. S. & Kempen, J. H., Nov 2009, In : Ophthalmology. 116, 11

Research output: Contribution to journalArticle

Eye Diseases
Methotrexate
Inflammation
Adrenal Cortex Hormones
Immunosuppressive Agents
26 Citations (Scopus)
Uveitis
Interleukin-1
Inflammation
Caspase 1
Interleukins
76 Citations (Scopus)

NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: Study of an international registry and a national cohort in Spain

Rosé, C. D., Aróstegui, J. I., Martin, T., Espada, G., Scalzi, L., Yagüe, J., Rosenbaum, J. J., Modesto, C., Arnal, M. C., Merino, R., García-Consuegra, J., Silva, M. A. C. & Wouters, C. H., Jun 2009, In : Arthritis and Rheumatism. 60, 6, p. 1797-1803 7 p.

Research output: Contribution to journalArticle

Spain
Registries
Phenotype
Mutation
Sialadenitis
33 Citations (Scopus)
Uveitis
Nucleotides
Acetylmuramyl-Alanyl-Isoglutamine
Inflammation
Intravitreal Injections
35 Citations (Scopus)

Nucleotide oligomerization domain-2 interacts with 2′-5′-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells

Dugan, J. W., Albor, A., David, L., Fowlkes, J., Blackledge, M. T., Martin, T., Planck, S., Rosenzweig, H., Rosenbaum, J. J. & Davey, M., Dec 2009, In : Molecular Immunology. 47, 2-3, p. 560-566 7 p.

Research output: Contribution to journalArticle

Ligases
Nucleotides
Innate Immunity
RNA Virus Infections
Double-Stranded RNA
117 Citations (Scopus)

Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: Retrospective cohort study

Kempen, J. H., Daniel, E., Dunn, J. P., Foster, C. S., Gangaputra, S., Hanish, A., Helzlsouer, K. J., Jabs, D. A., Kaçmaz, R. O., Levy-Clarke, G. A., Liesegang, T. L., Newcomb, C. W., Nussenblatt, R. B., Pujari, S. S., Rosenbaum, J. J., Suhler, E. & Thorne, J. E., Jul 11 2009, In : BMJ (Online). 339, 7712, p. 89-92 4 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Cohort Studies
Retrospective Studies
Inflammation
Mortality
41 Citations (Scopus)

Rituximab for treatment of ocular inflammatory disease: A series of four cases

Kurz, P. A., Suhler, E., Choi, D. & Rosenbaum, J. J., Apr 2009, In : British Journal of Ophthalmology. 93, 4, p. 546-548 3 p.

Research output: Contribution to journalArticle

Eye Diseases
Orbital Diseases
Scleritis
Prednisone
Therapeutics
70 Citations (Scopus)

The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity

Martin, T., Zhang, Z., Kurz, P., Rose, C. D., Chen, H., Lu, H., Planck, S., Davey, M. & Rosenbaum, J. J., Feb 2009, In : Arthritis and Rheumatism. 60, 2, p. 611-618 8 p.

Research output: Contribution to journalArticle

Interleukin-1
Cryopyrin-Associated Periodic Syndromes
Caspase 1
Inflammasomes
Interleukin 1 Receptor Antagonist Protein
100 Citations (Scopus)

The role of glia, mitochondria, and the immune system in glaucoma

Tezel, G., Ben-Hur, T., Gibson, G. E., Stevens, B., Streit, W. J., Wekerle, H., Bhattacharya, S. K., Borras, T., Burgoyne, C. F., Caspi, R. R., Chauhan, B. C., Clark, A. F., Crowston, J., Danias, J., Dick, A. D., Flammer, J., Foster, C. S., Grosskreutz, C. L., Grus, F. H., Guy, J. & 48 others, Hernandez, M. R., Johnson, E., Kaplan, H. J., Kuehn, M. H., Lenaers, G., Levin, L. A., Lindsey, J. D., Malina, H., Nickells, R. W., Osborne, N., Quigley, H. A., Rao, N., Rosenbaum, J. J., Sadun, A. A., Schwartz, M., Sun, D., Trounce, I., Wax, M. B., Yorio, T., Abrams, G. W., Atherton, S. S., Boatright, J. H., Chu, J., Dowling, J., Ferris, F. L., Garway-Heath, D., Gregory, M., Grzybowski, D. M., Gupta, N., Inman, D., Ju, W. K., Kang, K., Kaufman, H. E., Kaufman, P. L., Larssen, L. I., Liebmann, J., Lupien, C., Miller, R. F., Niesman, M., O'Brien, C., Petrash, J. M., Prasanna, G., Ritch, R., Shestopalov, V., Wirostko, B., WoldeMussie, E., Yue, B. & Zimmerman, T. J., Mar 2009, In : Investigative Ophthalmology and Visual Science. 50, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

2008
5 Citations (Scopus)

2007 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)

Colbert, R. A., Deodhar, A. A., Khan, M. A., Lories, R. J., Maksymowych, W. P., Reveille, J. D., Ritchlin, C. T., Rosenbaum, J. J., Targan, S. R., Weisman, M. & Clegg, D. O., Jul 2008, In : Journal of Rheumatology. 35, 7, p. 1398-1402 5 p.

Research output: Contribution to journalArticle

Education
Research
Therapeutics
Spondylarthritis
Interleukin-23
28 Citations (Scopus)

Activation of NOD2 in vivo induces IL-1β production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling

Rosenzweig, H., Martin, T., Planck, S., Galster, K., Jann, M. M., Davey, M., Kobayashi, K., Flavell, R. A. & Rosenbaum, J. J., Aug 1 2008, In : Journal of Leukocyte Biology. 84, 2, p. 529-536 8 p.

Research output: Contribution to journalArticle

Caspase 1
Interleukin-1
Nucleotides
Inflammation
Acetylmuramyl-Alanyl-Isoglutamine
3 Citations (Scopus)

Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis

Rosenzweig, H., Martin, T., Planck, S., Jann, M. M., Smith, J. R., Glant, T. T., Van Eden, W., Davey, M. & Rosenbaum, J. J., Apr 2008, In : Ophthalmic Research. 40, 3-4, p. 189-192 4 p.

Research output: Contribution to journalArticle

Anterior Uveitis
Joint Diseases
Ankylosing Spondylitis
T-Cell Antigen Receptor
Spondylitis
21 Citations (Scopus)

Antineutrophil cytoplasmic antibody-associated active scleritis

Hoang, L. T., Lim, L. L., Vaillant, B., Choi, D. & Rosenbaum, J. J., May 2008, In : Archives of Ophthalmology. 126, 5, p. 651-655 5 p.

Research output: Contribution to journalArticle

Scleritis
Antineutrophil Cytoplasmic Antibodies
Therapeutics
Eye Diseases
Alkylating Agents

A piece of my mind. In defense of phobias.

Rosenbaum, J. J., May 28 2008, In : JAMA : the journal of the American Medical Association. 299, 20, p. 2368 1 p.

Research output: Contribution to journalArticle

Attitude of Health Personnel
Clinical Competence
Phobic Disorders
Medical Students
Fear
13 Citations (Scopus)

Characterizing extravascular neutrophil migration in vivo in the iris

Planck, S., Becker, M. D., Crespo, S., Choi, D., Galster, K., Garman, K. L., Nobiling, R. & Rosenbaum, J. J., Apr 2008, In : Inflammation. 31, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

Iris
Neutrophils
Cytochalasin D
Video Microscopy
Uveitis

Clinical images: Incidental retinal vasculopathy: A clue to diagnosing systemic disease

Sharma, S. M., Richards, A. B., Lutt, J. R. & Rosenbaum, J. J., Oct 2008, In : Arthritis and Rheumatism. 58, 10, p. 3278 1 p.

Research output: Contribution to journalArticle

Retinal Diseases
Incidental Findings
Systemic Lupus Erythematosus
3 Citations (Scopus)
Viral Regulatory and Accessory Proteins
Eye Neoplasms
Human Immunodeficiency Virus tat Gene Products
Human Immunodeficiency Virus Proteins
Genetic Vectors
8 Citations (Scopus)

Experimental melanin-induced uveitis: Experimental model of human acute anterior uveitis

Smith, J. R., Rosenbaum, J. J. & Williams, K. A., Apr 2008, In : Ophthalmic Research. 40, 3-4, p. 136-140 5 p.

Research output: Contribution to journalArticle

Anterior Uveitis
Melanins
Uveitis
Theoretical Models
Inflammation

Foreword

Rosenbaum, J. J., 2008, In : Unknown Journal.

Research output: Contribution to journalArticle

Immunologic ocular disease

Rosenbaum, J. J., Becker, M. D. & Smith, J. R., 2008, Clinical Immunology. Elsevier Ltd, p. 1085-1097 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eye Diseases
Immune System Diseases
93 Citations (Scopus)

Incidence and Prevalence of Uveitis in Veterans Affairs Medical Centers of the Pacific Northwest

Suhler, E., Lloyd, M. J., Choi, D., Rosenbaum, J. J. & Austin, D. F., Dec 2008, In : American Journal of Ophthalmology. 146, 6

Research output: Contribution to journalArticle

Northwestern United States
Uveitis
Veterans
Incidence
Epidemiologic Studies
3 Citations (Scopus)

Injectable intraocular corticosteroids

Kurz, P. A., Suhler, E., Flaxel, C. & Rosenbaum, J. J., 2008, Surgical Management of Inflammatory Eye Disease. Springer Berlin Heidelberg, p. 5-16 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Intravitreal Injections
Adrenal Cortex Hormones
Injections
Retinal Artery Occlusion
Macular Edema
9 Citations (Scopus)

Invasion of human retinal vascular endothelial cells by Toxoplasma gondii tachyzoites

Zamora, D. O., Rosenbaum, J. J. & Smith, J. R., Jun 2008, In : British Journal of Ophthalmology. 92, 6, p. 852-855 4 p.

Research output: Contribution to journalArticle

Retinal Vessels
Toxoplasma
Endothelial Cells
Skin
Cell Culture Techniques
9 Citations (Scopus)

In vivo imaging of the immune response in the eye

Spencer, D. B., Lee, E., Kawaguchi, T. & Rosenbaum, J. J., Apr 2008, In : Seminars in Immunopathology. 30, 2, p. 179-190 12 p.

Research output: Contribution to journalArticle

Immune System
Animal Disease Models
Iris
Systems Analysis
Cornea
89 Citations (Scopus)

Long-term Risk of Malignancy Among Patients Treated With Immunosuppressive Agents for Ocular Inflammation: A Critical Assessment of the Evidence

Kempen, J. H., Gangaputra, S., Daniel, E., Levy-Clarke, G. A., Nussenblatt, R. B., Rosenbaum, J. J., Suhler, E., Thorne, J. E., Foster, C. S., Jabs, D. A. & Helzlsouer, K. J., Dec 2008, In : American Journal of Ophthalmology. 146, 6

Research output: Contribution to journalArticle

Immunosuppressive Agents
Inflammation
Neoplasms
Alkylating Agents
Skin Neoplasms
71 Citations (Scopus)

Methods for identifying long-term adverse effects of treatment in patients with eye diseases: The Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study

Kempen, J. H., Daniel, E., Gangaputra, S., Dreger, K., Jabs, D. A., Kaçmaz, R. O., Pujari, S. S., Anzaar, F., Foster, C. S., Helzlsouer, K. J., Levy-Clarke, G. A., Nussenblatt, R. B., Liesegang, T., Rosenbaum, J. J. & Suhler, E., Jan 2008, In : Ophthalmic Epidemiology. 15, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

Eye Diseases
Immunosuppressive Agents
Cohort Studies
Mortality
Antimetabolites
34 Citations (Scopus)

NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis

Rosenzweig, H., Martin, T., Jann, M. M., Planck, S., Davey, M., Kobayashi, K., Flavell, R. A. & Rosenbaum, J. J., Apr 2008, In : Investigative Ophthalmology and Visual Science. 49, 4, p. 1518-1524 7 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Uveitis
Peptidoglycan
Genes
L-Selectin
76 Citations (Scopus)

Ocular Inflammation in Behçet Disease: Incidence of Ocular Complications and of Loss of Visual Acuity

Kaçmaz, R. O., Kempen, J. H., Newcomb, C., Gangaputra, S., Daniel, E., Levy-Clarke, G. A., Nussenblatt, R. B., Rosenbaum, J. J., Suhler, E., Thorne, J. E., Jabs, D. A. & Foster, C. S., Dec 2008, In : American Journal of Ophthalmology. 146, 6, p. 828-836 9 p.

Research output: Contribution to journalArticle

Visual Acuity
Inflammation
Incidence
Intraocular Pressure
Confidence Intervals
64 Citations (Scopus)

Orbital Inflammatory Disease

Lutt, J. R., Lim, L. L., Phal, P. M. & Rosenbaum, J. J., Feb 2008, In : Seminars in Arthritis and Rheumatism. 37, 4, p. 207-222 16 p.

Research output: Contribution to journalArticle

Orbital Diseases
Ophthalmology
Immunosuppression
Orbital Myositis
Tolosa-Hunt Syndrome
12 Citations (Scopus)

Prediction of cis-regulatory elements controlling genes differentially expressed by retinal and choroidal vascular endothelial cells

Choi, D., Appukuttan, B., Binek, S. J., Planck, S., Stout, J. T., Rosenbaum, J. J. & Smith, J. R., 2008, In : Journal of Ocular Biology, Diseases, and Informatics. 1, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Retinal Vessels
Endothelial Cells
Transcription Factors
Genes
Gene Expression
3 Citations (Scopus)

T cell-antigen-presenting cell interactions visualized in vivo in a model of antigen-specific inflammation

Rosenbaum, J. J., Ronick, M. B., Song, X., Choi, D. & Planck, S., Mar 2008, In : Clinical Immunology. 126, 3, p. 270-276 7 p.

Research output: Contribution to journalArticle

Viral Tumor Antigens
Antigen-Presenting Cells
Cell Communication
Inflammation
T-Lymphocytes
1 Citation (Scopus)

Uveitis following the use of tumor necrosis factor α inhibitors: Comment on the article by Lim et al

Lim, L. L., Fraunfelder, F. W. & Rosenbaum, J. J., May 2008, In : Arthritis and Rheumatism. 58, 5, p. 1556-1557 2 p.

Research output: Contribution to journalArticle

Uveitis
Tumor Necrosis Factor-alpha
29 Citations (Scopus)

Uveitis secondary to bacterial products

Rosenbaum, J. J., Rosenzweig, H., Smith, J. R., Martin, T. & Planck, S., Apr 2008, In : Ophthalmic Research. 40, 3-4, p. 165-168 4 p.

Research output: Contribution to journalArticle

Uveitis
Acetylmuramyl-Alanyl-Isoglutamine
Laboratory Animals
Inflammation
Endotoxins
2007
10 Citations (Scopus)

Altered host: pathogen interactions conferred by the Blau syndrome mutation of NOD2

Kim, T. H., Payne, U., Zhang, X., Iwanaga, Y., Davey, M., Rosenbaum, J. J. & Inman, R. D., Jan 2007, In : Rheumatology International. 27, 3, p. 257-262 6 p.

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Salmonella typhimurium
Mutation
Microbial Interactions
Bacteria
1 Citation (Scopus)

Biologics and Behcet's: Disease diversity and trial design

Rosenbaum, J. J., Mar 2007, In : Ocular Immunology and Inflammation. 15, 2, p. 61-62 2 p.

Research output: Contribution to journalArticle

Behcet Syndrome
Immunosuppressive Agents
Biological Products
Randomized Controlled Trials
Immunoglobulin G
5 Citations (Scopus)

Can medical schools teach high school students to be scientists?

Rosenbaum, J. J., Martin, T., Farris, K. H., Rosenbaum, R. B. & Neuwelt, E., Jul 2007, In : FASEB Journal. 21, 9, p. 1954-1957 4 p.

Research output: Contribution to journalArticle

high school students
Medical Schools
students
Students
career planning
195 Citations (Scopus)

Do tumor necrosis factor inhibitors cause uveitis? A registry-based study

Lim, L. L., Fraunfelder, F. W. & Rosenbaum, J. J., Oct 2007, In : Arthritis and Rheumatism. 56, 10, p. 3248-3252 5 p.

Research output: Contribution to journalArticle

Uveitis
Registries
Tumor Necrosis Factor-alpha
Pharmaceutical Databases
Etanercept
5 Citations (Scopus)

Endotoxin upregulates CCR7 and its ligands in the lymphatic-free mouse iris

Mackensen, F., Metea, C. A., Planck, S. & Rosenbaum, J. J., Nov 28 2007, In : Molecular Vision. 13, p. 2209-2213 5 p.

Research output: Contribution to journalArticle

Iris
Endotoxins
Up-Regulation
Ligands
Lipopolysaccharides
78 Citations (Scopus)

Enhanced Recognition, Treatment, and Prognosis of Tubulointerstitial Nephritis and Uveitis Syndrome

Mackensen, F., Smith, J. R. & Rosenbaum, J. J., May 2007, In : Ophthalmology. 114, 5

Research output: Contribution to journalArticle

Uveitis
Anterior Uveitis
Therapeutics
Kidney
Visual Acuity
60 Citations (Scopus)

Expression of vascular endothelial growth factor and its receptors in rosacea

Smith, J. R., Lanier, V. B., Braziel, R., Falkenhagen, K. M., White, C. & Rosenbaum, J. J., Feb 2007, In : British Journal of Ophthalmology. 91, 2, p. 226-229 4 p.

Research output: Contribution to journalArticle

Rosacea
Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
Blood Vessels
Vascular Endothelium
14 Citations (Scopus)

Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina

Appukuttan, B., McFarland, T. J., Davies, M. H., Atchaneeyasakul, L. O., Zhang, Y., Babra, B., Pan, Y., Rosenbaum, J. J., Acott, T., Powers, M. M. & Stout, J. T., Aug 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3775-3782 8 p.

Research output: Contribution to journalArticle

Retina
Protein Isoforms
Endothelial Cells
Vascular Endothelial Growth Factor A
Retinal Vessels

Inflammatory vascular disease

Gadkari, S., Rosenbaum, J. J., MacKensen, F., Zierhut, M., Stübiger, N., Kötter, I., Deuter, C., Becker, M. D., Wiehler, U., Miller, D. W., Sivaprasad, S., Okhravi, N., Lightman, S., Davis, J. L., Huang, J. J. & Foster, C. S., 2007, Retinal Vascular Disease. Springer Berlin Heidelberg, p. 613-687 75 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vascular Diseases
Eponyms
Retinal Hemorrhage
Vitreous Hemorrhage
Epistaxis
39 Citations (Scopus)

Malignant B cells from patients with primary central nervous system lymphoma express stromal cell-derived factor-1

Smith, J. R., Falkenhagen, K. M., Coupland, S. E., Chipps, T. J., Rosenbaum, J. J. & Braziel, R., Apr 2007, In : American Journal of Clinical Pathology. 127, 4, p. 633-641 9 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Lymphoma
B-Lymphocytes
Central Nervous System
Chemokines
32 Citations (Scopus)

Management of orbital xanthogranuloma with methotrexate

Hayden, A., Wilson, D. & Rosenbaum, J. J., Apr 2007, In : British Journal of Ophthalmology. 91, 4, p. 434-436 3 p.

Research output: Contribution to journalArticle

Methotrexate
Adrenal Cortex Hormones
Inflammation
Therapeutics
Skin