Heidi Feiler

Research Associate Professor

  • 3303 SW Bond Avenue, CH13B, Portland OR 97239

  • 15295 Citations
  • 27 h-Index
1987 …2017
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Research Output 1987 2017

  • 15295 Citations
  • 27 h-Index
  • 41 Article
  • 2 Comment/debate
2017
13 Citations (Scopus)

Bayesian network inference modeling identifies TRIB1 as a novel regulator of cell-cycle progression and survival in cancer cells

Gendelman, R., Xing, H., Mirzoeva, O. K., Sarde, P., Curtis, C., Feiler, H., McDonagh, P., Gray, J., Khalil, I. & Korn, W. M., 2017, In : Cancer Research. 77, 7, p. 1575-1585 11 p.

Research output: Contribution to journalArticle

Cell Survival
Cell Cycle
Cyclin D1
Transcription Factor AP-1
Cell Cycle Checkpoints

Correction: Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer (PLoS ONE (2015) 10:7 (e0133219) DOI: 10.1371/journal.pone.0133219)

Korkola, J., Collisson, E. A., Heiser, L., Oates, C., Bayani, N., Itani, S., Esch, A., Thompson, W., Griffith, O. L., Wang, N. J., Kuo, W. L., Cooper, B., Billig, J., Ziyad, S., Hung, J. L., Jakkula, L., Feiler, H., Lu, Y., Mills, G., Spellman, P. & 3 others, Tomlin, C., Mukherjee, S. & Gray, J., Oct 1 2017, In : PLoS One. 12, 10, e0186551.

Research output: Contribution to journalComment/debate

phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
breast neoplasms
Names
Breast Neoplasms

Erratum to: "Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer", [Breast Cancer Research, 19, (2017) (17)] DOI: 10.1186/s13058-017-0809-6

Hu, Z., Mao, J. H., Curtis, C., Huang, G., Gu, S., Heiser, L., Lenburg, M. E., Korkola, J., Bayani, N., Samarajiwa, S., Seoane, J. A., Dane, M. A., Esch, A., Feiler, H., Wang, N. J., Hardwicke, M. A., Laquerre, S., Jackson, J., Wood, K. W., Weber, B. & 5 others, Spellman, P., Aparicio, S., Wooster, R., Caldas, C. & Gray, J., Feb 9 2017, In : Breast Cancer Research. 19, 1, 17.

Research output: Contribution to journalComment/debate

Gene Regulatory Networks
Names
Breast
Up-Regulation
Genome
63 Citations (Scopus)

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C. & 87 others, Vasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J. E., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L., Gray, J., Korkola, J., Mills, G., LaBarge, M., Feiler, H., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 1 2017, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

Cataloging
Libraries
Inborn Genetic Diseases
Molecular Imaging
Neurodegenerative Diseases
2016
5 Citations (Scopus)

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Hu, Z., Mao, J. H., Curtis, C., Huang, G., Gu, S., Heiser, L., Lenburg, M. E., Korkola, J., Bayani, N., Samarajiwa, S., Seoane, J. A., Dane, M., Esch, A., Feiler, H., Wang, N. J., Hardwicke, M. A., Laquerre, S., Jackson, J., Wood, K., Weber, B. & 5 others, Spellman, P., Aparicio, S., Wooster, R., Caldas, C. & Gray, J., Jul 1 2016, In : Breast Cancer Research. 18, 1, 70.

Research output: Contribution to journalArticle

Spindle Apparatus
Gene Regulatory Networks
Up-Regulation
Genome
Breast Neoplasms
2015
10 Citations (Scopus)

Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer

Korkola, J., Collisson, E. A., Heiser, L., Oates, C., Bayani, N., Itani, S., Esch, A., Thompson, W., Griffith, O. L., Wang, N. J., Kuo, W. L., Cooper, B., Billig, J., Ziyad, S., Hung, J. L., Feiler, H., Lu, Y., Mills, G., Spellman, P., Tomlin, C. & 3 others, Mukherjee, S., Gray, J. & Jakkula, L., Jul 16 2015, In : PLoS One. 10, 7, e0133219.

Research output: Contribution to journalArticle

phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
breast neoplasms
Breast Neoplasms
mutation
2012
5 Citations (Scopus)

Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study

Gizer, I. R., Ehlers, C. L., Vieten, C., Feiler, H., Gilder, D. A. & Wilhelmsen, K. C., Oct 2012, In : Psychiatric Genetics. 22, 5, p. 235-244 10 p.

Research output: Contribution to journalArticle

Impulsive Behavior
Alcoholism
Genome
Depression
Marijuana Abuse
256 Citations (Scopus)

Subtype and pathway specific responses to anticancer compounds in breast cancer

Heiser, L., Sadanandam, A., Kuo, W. L., Benz, S. C., Goldstein, T. C., Ng, S., Gibb, W. J., Wang, N. J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J. I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J., Durinck, S., Pepin, F., Guan, Y. & 23 others, Purdom, E., Neuvial, P., Bengtsson, H., Wood, K. W., Smith, P. G., Vassilev, L. T., Hennessy, B. T., Greshock, J., Bachman, K. E., Hardwicke, M. A., Park, J. W., Marton, L. J., Wolf, D. M., Collisson, E. A., Neve, R. M., Mills, G., Speed, T. P., Feiler, H., Richard, F. W., Haussler, D., Stuart, J. M., Gray, J. & Spellman, P., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2724-2729 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Line
Pharmaceutical Preparations
Therapeutics
Neoplasms
2011
3579 Citations (Scopus)

Integrated genomic analyses of ovarian carcinoma

Bell, D., Berchuck, A., Birrer, M., Chien, J., Cramer, D. W., Dao, F., Dhir, R., Disaia, P., Gabra, H., Glenn, P., Godwin, A. K., Gross, J., Hartmann, L., Huang, M., Huntsman, D. G., Iacocca, M., Imielinski, M., Kalloger, S., Karlan, B. Y., Levine, D. A. & 277 others, Mills, G., Morrison, C., Mutch, D., Olvera, N., Orsulic, S., Park, K., Petrelli, N., Rabeno, B., Rader, J. S., Sikic, B. I., Smith-Mccune, K., Sood, A. K., Bowtell, D., Penny, R., Testa, J. R., Chang, K., Dinh, H. H., Drummond, J. A., Fowler, G., Gunaratne, P., Hawes, A. C., Kovar, C. L., Lewis, L. R., Morgan, M. B., Newsham, I. F., Santibanez, J., Reid, J. G., Trevino, L. R., Wu, Y. Q., Wang, M., Muzny, D. M., Wheeler, D. A., Gibbs, R. A., Getz, G., Lawrence, M. S., Cibulskis, K., Sivachenko, A. Y., Sougnez, C., Voet, D., Wilkinson, J., Bloom, T., Ardlie, K., Fennell, T., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., Koboldt, D. C., McLellan, M. D., Wylie, T., Walker, J., O'Laughlin, M., Dooling, D. J., Fulton, L., Abbott, R., Dees, N. D., Zhang, Q., Kandoth, C., Wendl, M., Schierding, W., Shen, D., Harris, C. C., Schmidt, H., Kalicki, J., Delehaunty, K. D., Fronick, C. C., Demeter, R., Cook, L., Wallis, J. W., Lin, L., Magrini, V. J., Hodges, J. S., Eldred, J. M., Smith, S. M., Pohl, C. S., Vandin, F., Raphael, B. J., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Meyerson, M., Winckler, W., Getz, G., Verhaak, R. G. W., Carter, S. L., Mermel, C. H., Saksena, G., Nguyen, H., Onofrio, R. C., Lawrence, M. S., Hubbard, D., Gupta, S., Crenshaw, A., Ramos, A. H., Ardlie, K., Chin, L., Protopopov, A., Zhang, J., Kim, T. M., Perna, I., Xiao, Y., Zhang, H., Ren, G., Sathiamoorthy, N., Park, R. W., Lee, E., Park, P. J., Kucherlapati, R., Absher, D. M., Waite, L., Sherlock, G., Brooks, J. D., Li, J. Z., Xu, J., Myers, R. M., Laird, P. W., Cope, L., Herman, J. G., Shen, H., Weisenberger, D. J., Noushmehr, H., Pan, F., Triche, T., Berman, B. P., Spellman, P., Buckley, J., Baylin, S. B., Spellman, P. T., Purdom, E., Neuvial, P., Bengtsson, H., Jakkula, L. R., Durinck, S., Han, J., Dorton, S., Marr, H., Choi, Y. G., Wang, V., Wang, N. J., Feiler, H., Conboy, J. G., Gray, J., Feiler, H. S., Speed, T. P., Gray, J. W., Levine, D. A., Socci, N. D., Liang, Y., Taylor, B. S., Schultz, N., Borsu, L., Lash, A. E., Brennan, C., Viale, A., Sander, C., Ladanyi, M., Hoadley, K. A., Meng, S., Du, Y., Shi, Y., Li, L., Turman, Y. J., Zang, D., Helms, E. B., Balu, S., Zhou, X., Wu, J., Topal, M. D., Hayes, D. N., Perou, C. M., Getz, G., Voet, D., Saksena, G., Zhang, J., Zhang, H., Korkola, J., Heiser, L., Cibulskis, K., Hu, Z., Sivachenko, A., Jing, R., Park, R. W., Liu, Y., Park, P. J., Noble, M., Chin, L., Carter, H., Kim, D., Karchin, R., Spellman, P. T., Purdom, E., Neuvial, P., Bengtsson, H., Durinck, S., Han, J., Korkola, J. E., Heiser, L. M., Cho, R. J., Hu, Z., Parvin, B., Speed, T. P., Gray, J. W., Schultz, N., Cerami, E., Taylor, B. S., Olshen, A., Reva, B., Antipin, Y., Shen, R., Mankoo, P., Sheridan, R., Ciriello, G., Chang, W. K., Bernanke, J. A., Borsu, L., Levine, D. A., Ladanyi, M., Sander, C., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Sanborn, J. Z., Vaske, C. J., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Hoadley, K. A., Du, Y., Balu, S., Hayes, D. N., Perou, C. M., Wilkerson, M. D., Zhang, N., Akbani, R., Baggerly, K. A., Yung, W. K., Mills, G. B., Weinstein, J. N., Penny, R., Shelton, T., Grimm, D., Hatfield, M., Morris, S., Yena, P., Rhodes, P., Sherman, M., Paulauskis, J., Millis, S., Kahn, A., Greene, J. M., Sfeir, R., Jensen, M. A., Chen, J., Whitmore, J., Alonso, S., Jordan, J., Chu, A., Zhang, J., Barker, A., Compton, C., Eley, G., Ferguson, M., Fielding, P., Gerhard, D. S., Myles, R., Schaefer, C., Mills Shaw, K. R., Vaught, J., Vockley, J. B., Good, P. J., Guyer, M. S., Ozenberger, B., Peterson, J. & Thomson, E., Jun 30 2011, In : Nature. 474, 7353, p. 609-615 7 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Neoplasms
MicroRNAs
Methylation
12 Citations (Scopus)

Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study

Gizer, I. R., Ehlers, C. L., Vieten, C., Seaton-Smith, K. L., Feiler, H., Lee, J. V., Segall, S. K., Gilder, D. A. & Wilhelmsen, K. C., Jan 15 2011, In : Drug and Alcohol Dependence. 113, 2-3, p. 125-132 8 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Chromosomes
Genes
Diagnostic and Statistical Manual of Mental Disorders
3 Citations (Scopus)

Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study

Gizer, I. R., Ehlers, C. L., Vieten, C., Seaton-Smith, K. L., Feiler, H., Lee, J. V., Segall, S. K., Gilder, D. A. & Wilhelmsen, K. C., Apr 2011, In : Psychological Medicine. 41, 4, p. 799-808 10 p.

Research output: Contribution to journalArticle

Tobacco Use Disorder
San Francisco
Alcoholism
Chromosomes
Nicotine
533 Citations (Scopus)

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

Collisson, E. A., Sadanandam, A., Olson, P., Gibb, W. J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G. E., Jakkula, L., Feiler, H., Ko, A. H., Olshen, A. B., Danenberg, K. L., Tempero, M. A., Spellman, P., Hanahan, D. & Gray, J., Apr 2011, In : Nature Medicine. 17, 4, p. 500-503 4 p.

Research output: Contribution to journalArticle

Tumors
Adenocarcinoma
Neoplasms
Therapeutics
Genes
26 Citations (Scopus)

The Investigation into CYP2E1 in Relation to the Level of Response to Alcohol Through a Combination of Linkage and Association Analysis

Webb, A., Lind, P. A., Kalmijn, J., Feiler, H., Smith, T. L., Schuckit, M. A. & Wilhelmsen, K. C., Jan 2011, In : Alcoholism: Clinical and Experimental Research. 35, 1, p. 10-18 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Alcohols
Polymorphism
Single Nucleotide Polymorphism
Microsatellite Repeats
2010
52 Citations (Scopus)

Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer

Purcell, J. W., Davis, J., Reddy, M., Martin, S., Samayoa, K., Vo, H., Thomsen, K., Bean, P., Kuo, W. L., Ziyad, S., Billig, J., Feiler, H., Gray, J., Wood, K. W. & Cases, S., Jan 15 2010, In : Clinical Cancer Research. 16, 2, p. 566-576 11 p.

Research output: Contribution to journalArticle

Kinesin
Breast Neoplasms
Proteins
Mitosis
ispinesib
84 Citations (Scopus)

Exon-level microarray analyses identify alternative splicing programs in breast cancer

Lapuk, A., Marr, H., Jakkula, L., Pedro, H., Bhattacharya, S., Purdom, E., Hu, Z., Simpson, K., Pachter, L., Durinck, S., Wang, N., Parvin, B., Fontenay, G., Speed, T., Garbe, J., Stampfer, M., Bayandorian, H., Dorton, S., Clark, T. A., Schweitzer, A. & 5 others, Wyrobek, A., Feiler, H., Spellman, P., Conboy, J. & Gray, J., Jul 2010, In : Molecular Cancer Research. 8, 7, p. 961-974 14 p.

Research output: Contribution to journalArticle

Alternative Splicing
Microarray Analysis
Exons
Breast Neoplasms
Protein Isoforms
3392 Citations (Scopus)

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., Alexe, G., Lawrence, M., O'Kelly, M., Tamayo, P., Weir, B. A., Gabriel, S., Winckler, W., Gupta, S., Jakkula, L., Feiler, H. & 13 others, Hodgson, J. G., James, C. D., Sarkaria, J. N., Brennan, C., Kahn, A., Spellman, P., Wilson, R. K., Speed, T. P., Gray, J., Meyerson, M., Getz, G., Perou, C. M. & Hayes, D. N., Jan 19 2010, In : Cancer Cell. 17, 1, p. 98-110 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Gene Expression
Atlases
Genome
Mutation
5 Citations (Scopus)

The helix-loop-helix Id-1 inhibits PSA expression in prostate cancer cells

Zielinski, A. J., Fong, S., Allison, J., Kawahara, M., Coppe, J. P., Feiler, H., Lee, N. M. & Desprez, P. Y., May 15 2010, In : International Journal of Cancer. 126, 10, p. 2490-2496 7 p.

Research output: Contribution to journalArticle

Prostate-Specific Antigen
Prostatic Neoplasms
Basic Helix-Loop-Helix Transcription Factors
Gene Expression
Kallikreins
2009
24 Citations (Scopus)

A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047

Kuo, W. L., Das, D., Ziyad, S., Bhattacharya, S., Gibb, W. J., Heiser, L., Sadanandam, A., Fontenay, G. V., Hu, Z., Wang, N. J., Bayani, N., Feiler, H., Neve, R. M., Wyrobek, A. J., Spellman, P., Marton, L. J. & Gray, J., Dec 14 2009, In : BMC Medicine. 7, 77.

Research output: Contribution to journalArticle

Polyamines
Systems Analysis
Breast Neoplasms
Cell Line
Breast
265 Citations (Scopus)

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

Mirzoeva, O. K., Das, D., Heiser, L., Bhattacharya, S., Siwak, D., Gendelman, R., Bayani, N., Wang, N. J., Neve, R. M., Guan, Y., Hu, Z., Knight, Z., Feiler, H., Gascard, P., Parvin, B., Spellman, P., Shokat, K. M., Wyrobek, A. J., Bissell, M. J., McCormick, F. & 4 others, Kuo, W. L., Mills, G., Gray, J. & Korn, W. M., Jan 15 2009, In : Cancer Research. 69, 2, p. 565-572 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Phosphotransferases
Breast Neoplasms
83 Citations (Scopus)

Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts

Hodgson, J. G., Yeh, R. F., Ray, A., Wang, N. J., Smirnov, I., Yu, M., Hariono, S., Silber, J., Feiler, H., Gray, J., Spellman, P., Vandenberg, S. R., Berger, M. S. & James, C. D., Oct 2009, In : Neuro-Oncology. 11, 5, p. 477-487 11 p.

Research output: Contribution to journalArticle

Gene Dosage
Glioblastoma
Heterografts
Messenger RNA
Neoplasms
19 Citations (Scopus)

Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells

Dairkee, S. H., Sayeed, A., Luciani, G., Champion, S., Zhenhang, M., Jakkula, L. R., Feiler, H., Gray, J. & Moore, D. H., Oct 1 2009, In : Cancer Research. 69, 19, p. 7826-7834 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Gene Expression
Neoplasms
Genes
Phenotype
102 Citations (Scopus)

Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells

Garbe, J. C., Bhattacharya, S., Merchant, B., Bassett, E., Swisshelm, K., Feiler, H., Wyrobek, A. J. & Stampfer, M. R., Oct 1 2009, In : Cancer Research. 69, 19, p. 7557-7568 12 p.

Research output: Contribution to journalArticle

Telomere
Breast
Epithelial Cells
Population
Galactosidases
2008
4455 Citations (Scopus)

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

McLendon, R., Friedman, A., Bigner, D., Van Meir, E. G., Brat, D. J., Mastrogianakis, G. M., Olson, J. J., Mikkelsen, T., Lehman, N., Aldape, K., Yung, W. K. A., Bogler, O., Weinstein, J. N., VandenBerg, S., Berger, M., Prados, M., Muzny, D., Morgan, M., Scherer, S., Sabo, A. & 211 others, Nazareth, L., Lewis, L., Hall, O., Zhu, Y., Ren, Y., Alvi, O., Yao, J., Hawes, A., Jhangiani, S., Fowler, G., San Lucas, A., Kovar, C., Cree, A., Dinh, H., Santibanez, J., Joshi, V., Gonzalez-Garay, M. L., Miller, C. A., Milosavljevic, A., Donehower, L., Wheeler, D. A., Gibbs, R. A., Cibulskis, K., Sougnez, C., Fennell, T., Mahan, S., Wilkinson, J., Ziaugra, L., Onofrio, R., Bloom, T., Nicol, R., Ardlie, K., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., McLellan, M. D., Wallis, J., Larson, D. E., Shi, X., Abbott, R., Fulton, L., Chen, K., Koboldt, D. C., Wendl, M. C., Meyer, R., Tang, Y., Lin, L., Osborne, J. R., Dunford-Shore, B. H., Miner, T. L., Delehaunty, K., Markovic, C., Swift, G., Courtney, W., Pohl, C., Abbott, S., Hawkins, A., Leong, S., Haipek, C., Schmidt, H., Wiechert, M., Vickery, T., Scott, S., Dooling, D. J., Chinwalla, A., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Getz, G., Winckler, W., Verhaak, R. G. W., Lawrence, M. S., O'Kelly, M., Robinson, J., Alexe, G., Beroukhim, R., Carter, S., Chiang, D., Gould, J., Gupta, S., Korn, J., Mermel, C., Mesirov, J., Monti, S., Nguyen, H., Parkin, M., Reich, M., Stransky, N., Weir, B. A., Garraway, L., Golub, T., Meyerson, M., Chin, L., Protopopov, A., Zhang, J., Perna, I., Aronson, S., Sathiamoorthy, N., Ren, G., Yao, J., Wiedemeyer, W. R., Kim, H., Sek, W. K., Xiao, Y., Kohane, I. S., Seidman, J., Park, P. J., Kucherlapati, R., Laird, P. W., Cope, L., Herman, J. G., Weisenberger, D. J., Pan, F., Van Den Berg, D., Van Neste, L., Joo, M. Y., Schuebel, K. E., Baylin, S. B., Absher, D. M., Li, J. Z., Southwick, A., Brady, S., Aggarwal, A., Chung, T., Sherlock, G., Brooks, J. D., Myers, R. M., Spellman, P., Purdom, E., Jakkula, L. R., Lapuk, A. V., Marr, H., Dorton, S., Yoon, G. C., Han, J., Ray, A., Wang, V., Durinck, S., Robinson, M., Wang, N. J., Vranizan, K., Peng, V., Van Name, E., Fontenay, G. V., Ngai, J., Conboy, J. G., Parvin, B., Feiler, H., Speed, T. P., Gray, J., Brennan, C., Socci, N. D., Olshen, A., Taylor, B. S., Lash, A., Schultz, N., Reva, B., Antipin, Y., Stukalov, A., Gross, B., Cerami, E., Wei, Q. W., Qin, L. X., Seshan, V. E., Villafania, L., Cavatore, M., Borsu, L., Viale, A., Gerald, W., Sander, C., Ladanyi, M., Perou, C. M., Hayes, D. N., Topal, M. D., Hoadley, K. A., Qi, Y., Balu, S., Shi, Y., Wu, J., Penny, R., Bittner, M., Shelton, T., Lenkiewicz, E., Morris, S., Beasley, D., Sanders, S., Kahn, A., Sfeir, R., Chen, J., Nassau, D., Feng, L., Hickey, E., Barker, A., Gerhard, D. S., Vockley, J., Compton, C., Vaught, J., Fielding, P., Ferguson, M. L., Schaefer, C., Zhang, J., Madhavan, S., Buetow, K. H., Collins, F., Good, P., Guyer, M., Ozenberger, B., Peterson, J. & Thomson, E., Oct 23 2008, In : Nature. 455, 7216, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Atlases
Genes
DNA Methylation
Neoplasms
2006
51 Citations (Scopus)

A genome-wide screen for nicotine dependence susceptibility loci

Swan, G. E., Hops, H., Wilhelmsen, K. C., Lessov-Schlaggar, C. N., Cheng, L. S. C., Hudmon, K. S., Amos, C. I., Feiler, H., Ring, H. Z., Andrews, J. A., Tildesley, E. & Benowitz, N., Jun 5 2006, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 141, 4, p. 354-360 7 p.

Research output: Contribution to journalArticle

Tobacco Use Disorder
Chromosomes, Human, Pair 6
Tobacco Use
Genome
Chromosomes, Human, Pair 19
224 Citations (Scopus)

Breast tumor copy number aberration phenotypes and genomic instability

Fridlyand, J., Snijders, A. M., Ylstra, B., Li, H., Olshen, A., Segraves, R., Dairkee, S., Tokuyasu, T., Ljung, B. M., Jain, A. N., McLennan, J., Ziegler, J., Chin, K-Y., Devries, S., Feiler, H., Gray, J., Waldman, F., Pinkel, D. & Albertson, D. G., Apr 18 2006, In : BMC Cancer. 6, 96.

Research output: Contribution to journalArticle

Genomic Instability
Breast Neoplasms
Phenotype
Telomere
Neoplasms
909 Citations (Scopus)

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

Chin, K-Y., DeVries, S., Fridlyand, J., Spellman, P., Roydasgupta, R., Kuo, W. L., Lapuk, A., Neve, R. M., Qian, Z., Ryder, T., Chen, F., Feiler, H., Tokuyasu, T., Kingsley, C., Dairkee, S., Meng, Z., Chew, K., Pinkel, D., Jain, A., Ljung, B. M. & 4 others, Esserman, L., Albertson, D. G., Waldman, F. M. & Gray, J., Dec 2006, In : Cancer Cell. 10, 6, p. 529-541 13 p.

Research output: Contribution to journalArticle

I-kappa B Kinase
Breast Neoplasms
Neoplasms
Genome
RNA
2005
48 Citations (Scopus)

Autosomal linkage analysis for the level of response to alcohol

Schuckit, M. A., Wilhelmsen, K., Smith, T. L., Feiler, H., Lind, P., Lange, L. A. & Kalmijn, J., Nov 2005, In : Alcoholism: Clinical and Experimental Research. 29, 11, p. 1976-1982 7 p.

Research output: Contribution to journalArticle

Alcohols
Genes
Chromosomes, Human, Pair 10
Chromosomes
Alcoholism
14 Citations (Scopus)

Support for previously identified alcoholism susceptibility loci in a cohort selected for smoking behavior

Wilhelmsen, K. C., Swan, G. E., Cheng, L. S. C., Lessov-Schlaggar, C. N., Amos, C. I., Feiler, H., Hudmon, K. S., Ring, H. Z., Andrews, J. A., Tildesley, E., Benowitz, N. L. & Hops, H., Dec 2005, In : Alcoholism: Clinical and Experimental Research. 29, 12, p. 2108-2115 8 p.

Research output: Contribution to journalArticle

Chromosomes
Alcoholism
Genes
Smoking
Alcohols
2004
63 Citations (Scopus)

17q-Linked Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Without Tau Mutations with Tau and α-Synuclein Inclusions

Wilhelmsen, K. C., Forman, M. S., Rosen, H. J., Alving, L. I., Goldman, J., Feiger, J., Lee, J. V., Segall, S. K., Kramer, J. H., Lomen-Hoerth, C., Rankin, K. P., Johnson, J., Feiler, H., Weiner, M. W., Lee, V. M. Y., Trojanowski, J. Q. & Miller, B. L., Mar 2004, In : Archives of Neurology. 61, 3, p. 398-406 9 p.

Research output: Contribution to journalArticle

Synucleins
Mutation
San Francisco
Frontotemporal Dementia
Motor Neuron Disease
29 Citations (Scopus)

Autosomal Dominant Acute Necrotizing Encephalopathy Maps to 2q12.1-2q13

Neilson, D. E., Feiler, H., Wilhelmsen, K. C., Lynn, A., Eiben, R. M., Kerr, D. S. & Warman, M. L., Feb 2004, In : Annals of Neurology. 55, 2, p. 291-294 4 p.

Research output: Contribution to journalArticle

Brain Diseases
Chromosomes, Human, Pair 2
Electron Transport
Choline
Thalamus
27 Citations (Scopus)

Cohen syndrome in the Ohio Amish

Falk, M. J., Feiler, H., Neilson, D. E., Maxwell, K., Lee, J. V., Segall, S. K., Robin, N. H., Wilhelmsen, K. C., Träskelin, A. L., Kolehmainen, J., Lehesjoki, A. E., Wiznitzer, M. & Warman, M. L., Jul 1 2004, In : American Journal of Medical Genetics. 128 A, 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

Amish
Microcephaly
Muscle Hypotonia
Myopia
Intellectual Disability
94 Citations (Scopus)

Genomic screen for loci associated with alcohol dependence in mission indians

Ehlers, C. L., Gilder, D. A., Wall, T. L., Phillips, E., Feiler, H. & Wilhelmsen, K. C., Aug 15 2004, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 129 B, 1, p. 110-115 6 p.

Research output: Contribution to journalArticle

Alcoholism
Phenotype
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 12
14 Citations (Scopus)

The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics

Vieten, C., Seaton, K. L., Feiler, H. & Wilhelmsen, K. C., Oct 2004, In : Alcoholism: Clinical and Experimental Research. 28, 10, p. 1509-1516 8 p.

Research output: Contribution to journalArticle

San Francisco
Alcoholism
Genes
Demography
Phenotype
2003
45 Citations (Scopus)

Environmental and Genetic Determinants of Tobacco Use: Methodology for a Multidisciplinary, Longitudinal Family-Based Investigation

Swan, G. E., Hudmon, K. S., Jack, L. M., Hemberger, K., Carmelli, D., Khroyan, T. V., Ring, H. Z., Hops, H., Andrews, J. A., Tildesley, E., McBride, D., Benowitz, N., Webster, C., Wilhelmsen, K. C., Feiler, H., Koenig, B., Caron, L., Illes, J. & Li, S. C. C., Oct 2003, In : Cancer Epidemiology Biomarkers and Prevention. 12, 10, p. 994-1005 12 p.

Research output: Contribution to journalArticle

Tobacco Use
Tobacco Use Disorder
Tobacco
Smoking
Phenotype
225 Citations (Scopus)

Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome

Siegel, D. H., Ashton, G. H. S., Penagos, H. G., Lee, J. V., Feiler, H., Wilhelmsen, K. C., South, A. P., Smith, F. J. D., Prescott, A. R., Wessagowit, V., Oyama, N., Akiyama, M., Al Aboud, D., Al Aboud, K., Al Githami, A., Al Hawsawi, K., Al Ismaily, A., Al-Suwaid, R., Atherton, D. J., Caputo, R. & 22 others, Fine, J. D., Frieden, I. J., Fuchs, E., Haber, R. M., Harada, T., Kitajima, Y., Mallory, S. B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C. B., Wojnarowska, F., Zaghloul, A. B., Hamada, T., Mallipeddi, R., Eady, R. A. J., McLean, W. H. I., McGrath, J. A. & Epstein, E. H., Jul 1 2003, In : American Journal of Human Genetics. 73, 1, p. 174-187 14 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Caenorhabditis elegans
Extracellular Matrix
Actins
Caenorhabditis elegans Proteins
94 Citations (Scopus)

The search for genes related to a low-level response to alcohol determined by alcohol challenges

Wilhelmsen, K. C., Schuckit, M., Smith, T. L., Lee, J. V., Segall, S. K., Feiler, H. & Kalmijn, J., Jul 1 2003, In : Alcoholism: Clinical and Experimental Research. 27, 7, p. 1041-1047 7 p.

Research output: Contribution to journalArticle

Genes
Alcohols
Alcoholism
Chromosomes
Chromosomes, Human, Pair 22
2000
147 Citations (Scopus)

A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants

Kong, L. J., Orozco, B. M., Roe, J. L., Nagar, S., Ou, S., Feiler, H., Durfee, T., Miller, A. B., Gruissem, W., Robertson, D. & Hanley-Bowdoin, L., Jul 3 2000, In : EMBO Journal. 19, 13, p. 3485-3495 11 p.

Research output: Contribution to journalArticle

Geminiviridae
Retinoblastoma Protein
Organ Specificity
Viral DNA
Tissue
52 Citations (Scopus)

Retinoblastoma-related proteins in plants: Homologues or orthologues of their metazoan counterparts?

Durfee, T., Feiler, H. & Gruissem, W., 2000, In : Plant Molecular Biology. 43, 5-6, p. 635-642 8 p.

Research output: Contribution to journalArticle

Retinoblastoma Protein
plant proteins
Tumor Suppressor Proteins
Amino Acid Sequence Homology
binding properties
1995
17 Citations (Scopus)

A novel Arabidopsis type 1 protein phosphatase is highly expressed in male and female tissues and functionally complements a conditional cell cycle mutant of Aspergillus

Arundhati, A., Feiler, H., Traas, J., Zhang, H., Lunness, P. A. & Doonan, J. H., May 1995, In : Plant Journal. 7, 5, p. 823-834 12 p.

Research output: Contribution to journalArticle

Arabidopsis Proteins
phosphoprotein phosphatase
Phosphoprotein Phosphatases
Aspergillus
cell cycle
94 Citations (Scopus)

The higher plant Arabidopsis thaliana encodes a functional CDC48 homologue which is highly expressed in dividing and expanding cells

Feiler, H., Desprez, T., Santoni, V., Kronenberger, J., Caboche, M. & Traas, J., 1995, In : EMBO Journal. 14, 22, p. 5626-5637 12 p.

Research output: Contribution to journalArticle

Arabidopsis
Cell Division
Cells
Eukaryota
Saccharomyces cerevisiae
1991
33 Citations (Scopus)

Cloning of the pea cdc2 homologue by efficient immunological screening of PCR products

Feiler, H. & Jacobs, T. W., Sep 1991, In : Plant Molecular Biology. 17, 3, p. 321-333 13 p.

Research output: Contribution to journalArticle

Cloning
Peas
Organism Cloning
molecular cloning
peas
1990
114 Citations (Scopus)
Peas
Cell Division
Genes
Schizosaccharomyces
Plant Extracts
1987
15 Citations (Scopus)

Altered mitochondrial gene expression in the nonchromosomal stripe 2 mutant of maize

Feiler, H. & Newton, K. J., Jun 1 1987, In : EMBO Journal. 6, 6, p. 1535-1539 5 p.

Research output: Contribution to journalArticle

Mitochondria
Mitochondrial Genes
Gene expression
Zea mays
Gene Expression