Research Output 2008 2018

  • 613 Citations
  • 15 h-Index
  • 35 Article
  • 1 Chapter
  • 1 Letter
  • 1 Review article
2018
1 Citations

Diagnosing resistance to a proprotein convertase subtilisin/kexin type 9 inhibitor

Shapiro, M. D., Miles, J., Tavori, H. & Fazio, S. Mar 6 2018 In : Annals of Internal Medicine. 168, 5, p. 376-379 4 p.

Research output: Contribution to journalLetter

Proprotein Convertase 9
2017

A case of severe acquired hypertriglyceridemia in a 7-year-old girl

Lilley, J. S., Linton, M. F., Kelley, J. C., Graham, T. B., Fazio, S. & Tavori, H. 2017 (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Lipoprotein Lipase
Triglycerides
Hyperlipoproteinemia Type I
Pancreatitis
3 Citations
Lipoprotein(a)
LDL Cholesterol
Monoclonal Antibodies
LDL Lipoproteins
LDL Receptors
1 Citations

Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins

Fazio, S., Minnier, J., Shapiro, M. D., Tsimikas, S., Tarugi, P., Averna, M. R., Arca, M. & Tavori, H. Sep 1 2017 In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3340-3348 9 p.

Research output: Contribution to journalArticle

Angiopoietins
Lipoproteins
Proprotein Convertases
Subtilisin
Plasmas
2016
22 Citations

Biology of proprotein convertase subtilisin kexin 9: Beyond low-density lipoprotein cholesterol lowering

Norata, G. D., Tavori, H., Pirillo, A., Fazio, S. & Catapano, A. L. Oct 1 2016 In : Cardiovascular Research. 112, 1, p. 429-442 14 p.

Research output: Contribution to journalReview article

Proprotein Convertases
Subtilisin
LDL Cholesterol
Hypercholesterolemia
Cardiovascular Diseases
17 Citations

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE-and LDLR-mediated mechanisms

Tavori, H., Giunzioni, I., Predazzi, I. M., Plubell, D., Shivinsky, A., Miles, J., DeVay, R. M., Liang, H., Rashid, S., Linton, M. R. F. & Fazio, S. May 15 2016 In : Cardiovascular Research. 110, 2, p. 268-278 11 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipogenesis
LDL Receptors
Apolipoproteins E
Atherosclerosis
28 Citations

Local effects of human PCSK9 on the atherosclerotic lesion

Giunzioni, I., Tavori, H., Covarrubias, R., Major, A. S., Ding, L., Zhang, Y., Devay, R. M., Hong, L., Fan, D., Predazzi, I. M., Rashid, S., Linton, M. F. & Fazio, S. Jan 1 2016 In : Journal of Pathology. 238, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

LDL Receptors
Apolipoproteins E
Macrophages
Bone Marrow
Transgenic Mice
5 Citations

Loss of Macrophage Low-Density Lipoprotein Receptor–Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition

Zhu, L., Giunzioni, I., Tavori, H., Covarrubias, R., Ding, L., Zhang, Y., Ormseth, M., Major, A. S., Stafford, J. M., Linton, M. R. F. & Fazio, S. Jun 30 2016 (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
LDL Receptors
Apolipoproteins E
Tumor Necrosis Factor-alpha
Macrophages
26 Citations

PCSK9 Association With Lipoprotein(a)

Tavori, H., Christian, D., Minnier, J., Plubell, D., Shapiro, M. D., Yeang, C., Giunzioni, I., Croyal, M., Duell, P. B., Lambert, G., Tsimikas, S. & Fazio, S. Apr 29 2016 (Accepted/In press) In : Circulation Research.

Research output: Contribution to journalArticle

Lipoprotein(a)
Apoprotein(a)
LDL Lipoproteins
Proprotein Convertase 9
Apolipoproteins B

The biology of PCSK9 inhibition: Some unanswered questions

Lambert, G., Diotel, N. & Tavori, H. May 1 2016 In : European Heart Journal. 37, 17, p. 1345-1347 3 p.

Research output: Contribution to journalArticle

2015
11 Citations

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL

Tavori, H., Su, Y. R., Yancey, P. G., Giunzioni, I., Wilhelm, A. J., Blakemore, J. L., Zabalawi, M., Linton, M. F., Sorci-Thomas, M. G. & Fazio, S. Mar 1 2015 In : Journal of Lipid Research. 56, 3, p. 635-643 9 p.

Research output: Contribution to journalArticle

Dermatitis
Macrophages
Dyslipidemias
Atherosclerosis
T-cells
13 Citations

New developments in atherosclerosis: Clinical potential of PCSK9 inhibition

Giunzioni, I. & Tavori, H. Aug 24 2015 In : Vascular Health and Risk Management. 11, p. 493-501 9 p.

Research output: Contribution to journalArticle

Subtilisin
Atherosclerosis
Proteins
Monoclonal Antibodies
LDL Receptors
30 Citations

On the function and homeostasis of PCSK9: Reciprocal interaction with LDLR and additional lipid effects

Tavori, H., Rashid, S. & Fazio, S. Feb 1 2015 In : Atherosclerosis. 238, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

LDL Receptors
Homeostasis
Lipids
LDL Lipoproteins
Proprotein Convertase 9
10 Citations
Proprotein Convertases
Subtilisin
Cardiovascular Diseases
Lipoprotein(a)
LDL Receptors
Serine Endopeptidases
Proprotein Convertases
Enterocytes
LDL Receptors
Hypertriglyceridemia
15 Citations

Targeting PCSK9 for Therapeutic Gains

Shapiro, M. D., Fazio, S. & Tavori, H. 2015 In : Current Atherosclerosis Reports. 17, 4

Research output: Contribution to journalArticle

Cholesterol
Phase III Clinical Trials
Phase II Clinical Trials
Therapeutics
Hypercholesterolemia
2014
8 Citations

Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction

Tavori, H., Melone, M. & Rashid, S. Oct 1 2014 In : Expert Review of Cardiovascular Therapy. 12, 10, p. 1137-1144 8 p.

Research output: Contribution to journalArticle

LDL Cholesterol
LDL Receptors
Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Phase III Clinical Trials
9 Citations

Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: Role of serum cholesterol and temporal effects of exposure

Prins, P. A., Hill, M. F., Airey, D., Nwosu, S., Perati, P. R., Tavori, H., Linton, M. F., Kon, V., Fazio, S. & Sampson, U. K. Jan 23 2014 In : PLoS One. 9, 1, e84517

Research output: Contribution to journalArticle

aneurysm
angiotensins
Abdominal Aortic Aneurysm
Angiotensins
Angiotensin II

Correction to: Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction

Tavori, H., Melone, M. & Rashid, S. Dec 1 2014 In : Expert Review of Cardiovascular Therapy. 12, 12, p. 1491 1 p.

Research output: Contribution to journalArticle

LDL Cholesterol
alirocumab
3 Citations

Macrophage-derived apoESendaisuppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice

Tavori, H., Fan, D., Giunzioni, I., Zhu, L., Linton, M. F., Fogo, A. B. & Fazio, S. Oct 1 2014 In : Journal of Lipid Research. 55, 10, p. 2073-2081 9 p.

Research output: Contribution to journalArticle

Macrophages
Apolipoproteins E
Lipoproteins
Atherosclerosis
Apolipoprotein E2
1 Citations
Serine Endopeptidases
Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Proprotein Convertases
RNA Editing
9 Citations

PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts

Lee, S., Amici, S., Tavori, H., Zeng, W. M., Freeland, S., Fazio, S. & Notterpek, L. Nov 26 2014 In : Journal of Neuroscience. 34, 48, p. 16140-16152 13 p.

Research output: Contribution to journalArticle

Myelin Proteins
Actins
Lipids
Cholesterol
Schwann Cells
67 Citations
LDL Receptors
Apolipoproteins B
Lipoproteins
Triglycerides
Coronary Disease

Response to Duell et al

Tavori, H., Giunzioni, I., Linton, M. F. & Fazio, S. Jun 20 2014 In : Circulation Research. 115, 1

Research output: Contribution to journalArticle

Serine Endopeptidases
Proprotein Convertases
Hyperlipoproteinemia Type II
Blood Component Removal
LDL Lipoproteins
2013
44 Citations

Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis

Tavori, H., Giunzioni, I., Linton, M. F. & Fazio, S. Dec 6 2013 In : Circulation Research. 113, 12, p. 1290-1295 6 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Blood Component Removal
Lipoproteins
LDL Lipoproteins
81 Citations

Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor evidence for a reciprocal regulation

Tavori, H., Fan, D., Blakemore, J. L., Yancey, P. G., Ding, L., Linton, M. F. & Fazio, S. Jun 18 2013 In : Circulation. 127, 24, p. 2403-2413 11 p.

Research output: Contribution to journalArticle

LDL Receptors
Serum
Cholesterol
Proprotein Convertase 9
LDL Lipoproteins
2012
15 Citations

Glabridin protects paraoxonase 1 from linoleic acid hydroperoxide inhibition via specific interaction: A fluorescence-quenching study

Atrahimovich, D., Vaya, J., Tavori, H. & Khatib, S. Apr 11 2012 In : Journal of Agricultural and Food Chemistry. 60, 14, p. 3679-3685 7 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
hydroperoxides
linoleic acid
Quenching
Fluorescence
8 Citations

Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid

Gamliel-Lazarovich, A., Abassi, Z., Khatib, S., Tavori, H., Vaya, J., Aviram, M. & Keidar, S. May 2012 In : Atherosclerosis. 222, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Hypotension
TRPV Cation Channels
Blood Pressure
Knockout Mice
2 Citations

PCSK9, a novel target for lowering LDL cholesterol: Promise and progress

Tavori, H., Fazio, S. & Linton, M. F. Dec 2012 In : Clinical Lipidology. 7, 6, p. 611-615 5 p.

Research output: Contribution to journalArticle

LDL Cholesterol
Hyperlipoproteinemia Type II
Monoclonal Antibodies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Safety
2011
23 Citations

Human carotid lesion linoleic acid hydroperoxide inhibits paraoxonase 1 (PON1) activity via reaction with PON1 free sulfhydryl cysteine 284

Tavori, H., Aviram, M., Khatib, S., Musa, R., Mannheim, D., Karmeli, R. & Vaya, J. Jan 1 2011 In : Free Radical Biology and Medicine. 50, 1, p. 148-156 9 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Cysteine
Lipids
Enzyme inhibition
Enzymes
10 Citations

Oxysterols formation as a reflection of biochemical pathways: Summary of in vitro and in vivo studies

Vaya, J., Szuchman, A., Tavori, H. & Aluf, Y. Sep 2011 In : Chemistry and Physics of Lipids. 164, 6, p. 438-442 5 p.

Research output: Contribution to journalArticle

Cholesterol
Oxidative stress
Oxidative Stress
Aryldialkylphosphatase
Medical problems
20 Citations

Paraoxonase 1 protects macrophages from atherogenicity of a specific triglyceride isolated from human carotid lesion

Tavori, H., Aviram, M., Khatib, S., Musa, R., Mannheim, D., Karmeli, R. & Vaya, J. Jul 1 2011 In : Free Radical Biology and Medicine. 51, 1, p. 234-242 9 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Macrophages
Triglycerides
Lipids
Oxidative stress
13 Citations

Structure-activity relationships of flavonoids

Jacob, V., Hagai, T. & Soliman, K. 2011 In : Current Organic Chemistry. 15, 15, p. 2641-2657 17 p.

Research output: Contribution to journalArticle

Flavonoids
Bleaching Agents
Estrogen Receptor beta
Oxidative stress
Monophenol Monooxygenase
24 Citations

Vitamin E therapy results in a reduction in HDL function in individuals with diabetes and the haptoglobin 2-1 genotype

Farbstein, D. , Blum, S. , Pollak, M. , Asaf, R. , Viener, H. L. , Lache, O. , Asleh, R. , Miller-Lotan, R. , Barkay, I. , Star, M. , Schwartz, A. , Kalet-Littman, S. , Ozeri, D. , Vaya, J. , Tavori, H. , Vardi, M. , Laor, A. , Bucher, S. E. , Anbinder, Y. , Moskovich, D. & 4 others Abbas, N., Perry, N., Levy, Y. & Levy, A. P. Nov 2011 In : Atherosclerosis. 219, 1, p. 240-244 5 p.

Research output: Contribution to journalArticle

Haptoglobins
Vitamin E
Genotype
Pharmacogenetics
Placebos
2010
17 Citations

Paraoxonase 1 attenuates human plaque atherogenicity: Relevance to the enzyme lactonase activity

Tavori, H., Vaya, J. & Aviram, M. 2010 Advances in Experimental Medicine and Biology. Vol. 660, p. 99-111 13 p. (Advances in Experimental Medicine and Biology; vol. 660)

Research output: Chapter in Book/Report/Conference proceedingChapter

Enzyme activity
Aryldialkylphosphatase
Lipids
Enzymes
Macrophages
8 Citations

Paraoxonase 1 interactions with atherosclerotic lesions and arterial macrophages protect against foam cell formation and atherosclerosis development

Tavori, H., Rosenblat, M., Vaya, J. & Aviram, M. Oct 2010 In : Clinical Lipidology. 5, 5, p. 685-697 13 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Foam Cells
Atherosclerosis
Macrophages
Antioxidants
2009
39 Citations

Human carotid atherosclerotic plaque increases oxidative state of macrophages and low-density lipoproteins, whereas paraoxonase 1 (PON1) decreases such atherogenic effects

Tavori, H., Aviram, M., Khatib, S., Musa, R., Nitecki, S., Hoffman, A. & Vaya, J. Mar 1 2009 In : Free Radical Biology and Medicine. 46, 5, p. 607-615 9 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Macrophages
Atherosclerotic Plaques
LDL Lipoproteins
Lipids
2008
30 Citations

Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity

Tavori, H., Khatib, S., Aviram, M. & Vaya, J. Aug 1 2008 In : Bioorganic and Medicinal Chemistry. 16, 15, p. 7504-7509 6 p.

Research output: Contribution to journalArticle

Lactones
Catalytic Domain
Computer simulation
Ligands
Organophosphates