Research Output 2008 2017

  • 514 Citations
  • 14 h-Index
  • 35 Article
  • 1 Chapter
  • 1 Review article
2017

A case of severe acquired hypertriglyceridemia in a 7-year-old girl

Lilley, J. S., Linton, M. F., Kelley, J. C., Graham, T. B., Fazio, S. & Tavori, H. 2017 (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Research - peer-reviewArticle

Hypertriglyceridemia
Triglycerides
Lipoprotein Lipase
Pancreatitis
Hyperlipoproteinemia Type I
1 Citations
Lipoprotein(a)
LDL Cholesterol
Monoclonal Antibodies
Proprotein Convertase 9
LDL Lipoproteins

Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins

Fazio, S., Minnier, J., Shapiro, M. D., Tsimikas, S., Tarugi, P., Averna, M. R., Arca, M. & Tavori, H. Sep 1 2017 In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3340-3348 9 p.

Research output: Research - peer-reviewArticle

Angiopoietins
Lipoproteins
Plasmas
LDL Lipoproteins
Proprotein Convertase 9
2016
10 Citations

Biology of proprotein convertase subtilisin kexin 9: Beyond low-density lipoprotein cholesterol lowering

Norata, G. D., Tavori, H., Pirillo, A., Fazio, S. & Catapano, A. L. Oct 1 2016 In : Cardiovascular Research. 112, 1, p. 429-442 14 p.

Research output: Research - peer-reviewReview article

Proprotein Convertases
Subtilisin
LDL Cholesterol
Hypercholesterolemia
Cardiovascular Diseases
8 Citations

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE-and LDLR-mediated mechanisms

Tavori, H., Giunzioni, I., Predazzi, I. M., Plubell, D., Shivinsky, A., Miles, J., DeVay, R. M., Liang, H., Rashid, S., Linton, M. R. F. & Fazio, S. May 15 2016 In : Cardiovascular Research. 110, 2, p. 268-278 11 p.

Research output: Research - peer-reviewArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipogenesis
LDL Receptors
Atherosclerosis
Liver
19 Citations

Local effects of human PCSK9 on the atherosclerotic lesion

Giunzioni, I., Tavori, H., Covarrubias, R., Major, A. S., Ding, L., Zhang, Y., Devay, R. M., Hong, L., Fan, D., Predazzi, I. M., Rashid, S., Linton, M. F. & Fazio, S. Jan 1 2016 In : Journal of Pathology. 238, 1, p. 52-62 11 p.

Research output: Research - peer-reviewArticle

Proprotein Convertase 9
human PCSK9 protein
LDL Receptors
Macrophages
Apolipoproteins E
4 Citations

Loss of Macrophage Low-Density Lipoprotein Receptor–Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition

Zhu, L., Giunzioni, I., Tavori, H., Covarrubias, R., Ding, L., Zhang, Y., Ormseth, M., Major, A. S., Stafford, J. M., Linton, M. R. F. & Fazio, S. Jun 30 2016 (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Research - peer-reviewArticle

Low Density Lipoprotein Receptor-Related Protein-1
Tumor Necrosis Factor-alpha
Macrophages
LDL Receptors
Apolipoproteins E
18 Citations

PCSK9 Association With Lipoprotein(a)

Tavori, H., Christian, D., Minnier, J., Plubell, D., Shapiro, M. D., Yeang, C., Giunzioni, I., Croyal, M., Duell, P. B., Lambert, G., Tsimikas, S. & Fazio, S. Apr 29 2016 (Accepted/In press) In : Circulation Research.

Research output: Research - peer-reviewArticle

Lipoprotein(a)
Proprotein Convertase 9
Apoprotein(a)
LDL Lipoproteins
Apolipoproteins B

The biology of PCSK9 inhibition: Some unanswered questions

Lambert, G., Diotel, N. & Tavori, H. May 1 2016 In : European Heart Journal. 37, 17, p. 1345-1347 3 p.

Research output: Research - peer-reviewArticle

2015
7 Citations

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL

Tavori, H., Su, Y. R., Yancey, P. G., Giunzioni, I., Wilhelm, A. J., Blakemore, J. L., Zabalawi, M., Linton, M. F., Sorci-Thomas, M. G. & Fazio, S. Mar 1 2015 In : Journal of Lipid Research. 56, 3, p. 635-643 9 p.

Research output: Research - peer-reviewArticle

Dermatitis
Dyslipidemias
Atherosclerosis
Macrophages
T-Lymphocytes
13 Citations

New developments in atherosclerosis: Clinical potential of PCSK9 inhibition

Giunzioni, I. & Tavori, H. Aug 24 2015 In : Vascular Health and Risk Management. 11, p. 493-501 9 p.

Research output: Research - peer-reviewArticle

Subtilisin
Atherosclerosis
Proteins
Monoclonal Antibodies
LDL Receptors
25 Citations

On the function and homeostasis of PCSK9: Reciprocal interaction with LDLR and additional lipid effects

Tavori, H., Rashid, S. & Fazio, S. Feb 1 2015 In : Atherosclerosis. 238, 2, p. 264-270 7 p.

Research output: Research - peer-reviewArticle

LDL Receptors
Homeostasis
Lipids
Proprotein Convertase 9
LDL Lipoproteins
8 Citations
Proprotein Convertases
Subtilisin
Cardiovascular Diseases
Therapeutics
Lipoprotein(a)
14 Citations

Targeting PCSK9 for Therapeutic Gains

Shapiro, M. D., Fazio, S. & Tavori, H. 2015 In : Current Atherosclerosis Reports. 17, 4

Research output: Research - peer-reviewArticle

Therapeutics
Proprotein Convertase 9
Cholesterol
Phase III Clinical Trials
Phase II Clinical Trials
2014
8 Citations

Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction

Tavori, H., Melone, M. & Rashid, S. Oct 1 2014 In : Expert Review of Cardiovascular Therapy. 12, 10, p. 1137-1144 8 p.

Research output: Research - peer-reviewArticle

LDL Cholesterol
alirocumab
Proprotein Convertase 9
LDL Receptors
Cholesterol
7 Citations

Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: Role of serum cholesterol and temporal effects of exposure

Prins, P. A., Hill, M. F., Airey, D., Nwosu, S., Perati, P. R., Tavori, H., Linton, M. F., Kon, V., Fazio, S. & Sampson, U. K. Jan 23 2014 In : PLoS One. 9, 1, e84517

Research output: Research - peer-reviewArticle

aneurysm
angiotensins
cholesterol
mice
Abdominal Aortic Aneurysm

Correction to: Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction

Tavori, H., Melone, M. & Rashid, S. Dec 1 2014 In : Expert Review of Cardiovascular Therapy. 12, 12, p. 1491 1 p.

Research output: Research - peer-reviewArticle

3 Citations

Macrophage-derived apoESendaisuppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice

Tavori, H., Fan, D., Giunzioni, I., Zhu, L., Linton, M. F., Fogo, A. B. & Fazio, S. Oct 1 2014 In : Journal of Lipid Research. 55, 10, p. 2073-2081 9 p.

Research output: Research - peer-reviewArticle

Apolipoproteins E
Atherosclerosis
Macrophages
Lipoprotein Glomerulopathy
Lipoproteins
1 Citations
6 Citations

PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts

Lee, S., Amici, S., Tavori, H., Zeng, W. M., Freeland, S., Fazio, S. & Notterpek, L. Nov 26 2014 In : Journal of Neuroscience. 34, 48, p. 16140-16152 13 p.

Research output: Research - peer-reviewArticle

Myelin Proteins
Actins
Lipids
Cholesterol
Schwann Cells
53 Citations
LDL Receptors
Apolipoproteins B
Lipoproteins
Triglycerides
Proprotein Convertase 9

Response to Duell et al

Tavori, H., Giunzioni, I., Linton, M. F. & Fazio, S. Jun 20 2014 In : Circulation Research. 115, 1

Research output: Research - peer-reviewArticle

2013
36 Citations

Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis

Tavori, H., Giunzioni, I., Linton, M. F. & Fazio, S. Dec 6 2013 In : Circulation Research. 113, 12, p. 1290-1295 6 p.

Research output: Research - peer-reviewArticle

Proprotein Convertases
Subtilisin
Blood Component Removal
Lipoproteins
LDL Lipoproteins
70 Citations

Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor evidence for a reciprocal regulation

Tavori, H., Fan, D., Blakemore, J. L., Yancey, P. G., Ding, L., Linton, M. F. & Fazio, S. Jun 18 2013 In : Circulation. 127, 24, p. 2403-2413 11 p.

Research output: Research - peer-reviewArticle

LDL Receptors
Serum
Proprotein Convertase 9
Cholesterol
Liver
2012
14 Citations

Glabridin protects paraoxonase 1 from linoleic acid hydroperoxide inhibition via specific interaction: A fluorescence-quenching study

Atrahimovich, D., Vaya, J., Tavori, H. & Khatib, S. Apr 11 2012 In : Journal of Agricultural and Food Chemistry. 60, 14, p. 3679-3685 7 p.

Research output: Research - peer-reviewArticle

hydroperoxides
linoleic acid
fluorescence
enzymes
aryldialkylphosphatase
8 Citations

Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid

Gamliel-Lazarovich, A., Abassi, Z., Khatib, S., Tavori, H., Vaya, J., Aviram, M. & Keidar, S. May 2012 In : Atherosclerosis. 222, 1, p. 92-98 7 p.

Research output: Research - peer-reviewArticle

Hypotension
Blood Pressure
5,6-epoxy-8,11,14-eicosatrienoic acid
Aryldialkylphosphatase
TRPV Cation Channels
2 Citations

PCSK9, a novel target for lowering LDL cholesterol: Promise and progress

Tavori, H., Fazio, S. & Linton, M. F. Dec 2012 In : Clinical Lipidology. 7, 6, p. 611-615 5 p.

Research output: Research - peer-reviewArticle

LDL Cholesterol
Monoclonal Antibodies
Hyperlipoproteinemia Type II
Safety
alirocumab
2011
23 Citations

Human carotid lesion linoleic acid hydroperoxide inhibits paraoxonase 1 (PON1) activity via reaction with PON1 free sulfhydryl cysteine 284

Tavori, H., Aviram, M., Khatib, S., Musa, R., Mannheim, D., Karmeli, R. & Vaya, J. Jan 1 2011 In : Free Radical Biology and Medicine. 50, 1, p. 148-156 9 p.

Research output: Research - peer-reviewArticle

Aryldialkylphosphatase
Cysteine
linoleic acid hydroperoxide
Lipids
Enzymes
10 Citations

Oxysterols formation as a reflection of biochemical pathways: Summary of in vitro and in vivo studies

Vaya, J., Szuchman, A., Tavori, H. & Aluf, Y. Sep 2011 In : Chemistry and Physics of Lipids. 164, 6, p. 438-442 5 p.

Research output: Research - peer-reviewArticle

Cholesterol
In Vitro Techniques
Oxysterols
Oxidative Stress
Oxidative stress
20 Citations

Paraoxonase 1 protects macrophages from atherogenicity of a specific triglyceride isolated from human carotid lesion

Tavori, H., Aviram, M., Khatib, S., Musa, R., Mannheim, D., Karmeli, R. & Vaya, J. Jul 1 2011 In : Free Radical Biology and Medicine. 51, 1, p. 234-242 9 p.

Research output: Research - peer-reviewArticle

Aryldialkylphosphatase
Macrophages
Triglycerides
Lipids
Oxidative stress
13 Citations

Structure-activity relationships of flavonoids

Jacob, V., Hagai, T. & Soliman, K. 2011 In : Current Organic Chemistry. 15, 15, p. 2641-2657 17 p.

Research output: Research - peer-reviewArticle

Flavonoids
Enzymes
Experiments
Bleaching Agents
Estrogen Receptor beta
24 Citations

Vitamin E therapy results in a reduction in HDL function in individuals with diabetes and the haptoglobin 2-1 genotype

Farbstein, D. , Blum, S. , Pollak, M. , Asaf, R. , Viener, H. L. , Lache, O. , Asleh, R. , Miller-Lotan, R. , Barkay, I. , Star, M. , Schwartz, A. , Kalet-Littman, S. , Ozeri, D. , Vaya, J. , Tavori, H. , Vardi, M. , Laor, A. , Bucher, S. E. , Anbinder, Y. , Moskovich, D. & 4 others Abbas, N., Perry, N., Levy, Y. & Levy, A. P. Nov 2011 In : Atherosclerosis. 219, 1, p. 240-244 5 p.

Research output: Research - peer-reviewArticle

Haptoglobins
Vitamin E
Genotype
Distance Counseling
Pharmacogenetics
2010
16 Citations

Paraoxonase 1 attenuates human plaque atherogenicity: Relevance to the enzyme lactonase activity

Tavori, H., Vaya, J. & Aviram, M. 2010 Advances in Experimental Medicine and Biology. Vol. 660, p. 99-111 13 p. (Advances in Experimental Medicine and Biology; vol. 660)

Research output: ResearchChapter

Enzyme activity
Lipids
human PON1 protein
Enzymes
Aryldialkylphosphatase
7 Citations

Paraoxonase 1 interactions with atherosclerotic lesions and arterial macrophages protect against foam cell formation and atherosclerosis development

Tavori, H., Rosenblat, M., Vaya, J. & Aviram, M. Oct 2010 In : Clinical Lipidology. 5, 5, p. 685-697 13 p.

Research output: Research - peer-reviewArticle

Aryldialkylphosphatase
Foam Cells
Atherosclerosis
Macrophages
Antioxidants
2009
38 Citations

Human carotid atherosclerotic plaque increases oxidative state of macrophages and low-density lipoproteins, whereas paraoxonase 1 (PON1) decreases such atherogenic effects

Tavori, H., Aviram, M., Khatib, S., Musa, R., Nitecki, S., Hoffman, A. & Vaya, J. Mar 1 2009 In : Free Radical Biology and Medicine. 46, 5, p. 607-615 9 p.

Research output: Research - peer-reviewArticle

Aryldialkylphosphatase
Atherosclerotic Plaques
LDL Lipoproteins
Macrophages
Lipids
2008
28 Citations

Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity

Tavori, H., Khatib, S., Aviram, M. & Vaya, J. Aug 1 2008 In : Bioorganic and Medicinal Chemistry. 16, 15, p. 7504-7509 6 p.

Research output: Research - peer-reviewArticle

Lactones
Computer simulation
Catalytic Domain
Ligands
Enzymes