Haesun Park

Research Assistant Professor

  • 1255 Citations
  • 16 h-Index
19952018
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Research Output 1995 2018

  • 1255 Citations
  • 16 h-Index
  • 21 Article
2018
14 Citations (Scopus)

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Okoye, A., Hansen, S., Vaidya, M., Fukazawa, Y., Park, H., Duell, D. M., Lum, R., Hughes, C. M., Ventura, A. B., Ainslie, E., Ford, J. C., Morrow, D., Gilbride, R. M., Legasse, A. W., Hesselgesser, J., Geleziunas, R., Li, Y., Oswald, K., Shoemaker, R., Fast, R. & 6 others, Bosche, W. J., Borate, B. R., Edlefsen, P. T., Axthelm, M., Picker, L. & Lifson, J. D., Sep 1 2018, In : Nature Medicine. 24, 9, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Secondary Prevention
Viruses
Cytomegalovirus
Macaca mulatta
6 Citations (Scopus)

Potent immune modulation by medi6383, an engineered human ox40 ligand igg4p fc fusion protein

Oberst, M. D., Auge, C., Morris, C., Kentner, S., Mulgrew, K., McGlinchey, K., Hair, J., Hanabuchi, S., Du, Q., Damschroder, M., Feng, H., Eck, S., Buss, N., de Haan, L., Pierce, A. J., Park, H., Sylwester, A., Axthelm, M., Picker, L., Morris, N. P. & 2 others, Weinberg, A. & Hammond, S. A., May 1 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1024-1038 15 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Proteins
Cell Proliferation
Neoplasms
Cytokines
56 Citations (Scopus)

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Hansen, S., Zak, D. E., Xu, G., Ford, J. C., Marshall, E., Malouli, D., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Randall, K. T., Selseth, A. N., Rundstrom, P., Herlache, L., Lewis, M. S., Park, H., Planer, S. L., Turner, J. M., Fischer, M., Armstrong, C. & 20 others, Zweig, R. C., Valvo, J., Braun, J. M., Shankar, S., Lu, L., Sylwester, A., Legasse, A. W., Messerle, M., Jarvis, M. A., Amon, L. M., Aderem, A., Alter, G., Laddy, D. J., Stone, M., Bonavia, A., Evans, T. G., Axthelm, M., Frueh, K., Edlefsen, P. T. & Picker, L., Feb 1 2018, In : Nature Medicine. 24, 2, p. 130-143 14 p.

Research output: Contribution to journalArticle

Cytomegalovirus Vaccines
Macaca mulatta
Tuberculosis
Vaccines
Tissue
2015
248 Citations (Scopus)

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Fukazawa, Y., Lum, R., Okoye, A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. & 2 others, Lifson, J. D. & Picker, L., 2015, In : Nature Medicine. 21, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Viruses
B-Lymphocytes
T-cells
16 Citations (Scopus)

Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance

Yang, O. O., Ali, A., Kasahara, N., Faure-Kumar, E., Bae, J. Y., Picker, L. & Park, H., 2015, In : Journal of Virology. 89, 2, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

conserved sequences
Conserved Sequence
Human immunodeficiency virus 1
HIV-1
Vaccines
26 Citations (Scopus)

Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates

Shen, X., Duffy, R., Howington, R., Cope, A., Sadagopal, S., Park, H., Pal, R., Kwa, S., Ding, S., Yang, O. O., Fouda, G. G., Grand, R. L., Bolton, D., Esteban, M., Phogat, S., Roederer, M., Amara, R. R., Picker, L., Seder, R. A., Juliana McElrath, M. & 10 others, Barnett, S., Permar, S. R., Shattock, R., DeVico, A. L., Felber, B. K., Pavlakis, G. N., Pantaleo, G., Korber, B. T., Montefiori, D. C. & Tomaras, G. D., 2015, In : Journal of Virology. 89, 16, p. 8643-8650 8 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Human immunodeficiency virus 1
Primates
epitopes
2014
23 Citations (Scopus)

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

Del Prete, G. Q., Park, H., Fennessey, C. M., Reid, C., Lipkey, L., Newman, L., Oswald, K., Kahl, C., Piatak, M., Quiñones, O. A., Gregory Alvord, W., Smedley, J., Estes, J., Lifson, J. D., Picker, L. & Keele, B. F., 2014, In : Journal of Virology. 88, 14, p. 8077-8090 14 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
swarms
Sequence Analysis
sequence analysis
2013
38 Citations (Scopus)

Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV gag protein-induced t cell responses in nonhuman primates

Park, H., Adamson, L., Ha, T., Mullen, K., Hagen, S. I., Nogueron, A., Sylwester, A., Axthelm, M., Legasse, A., Piatak, M., Lifson, J. D., McElrath, J. M., Picker, L. & Seder, R. A., Apr 15 2013, In : Journal of Immunology. 190, 8, p. 4103-4115 13 p.

Research output: Contribution to journalArticle

gag Gene Products
Poly I-C
Primates
T-Lymphocytes
Macaca mulatta
2012
103 Citations (Scopus)

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Fukazawa, Y., Park, H., Cameron, M. J., Lefebvre, F., Lum, R., Coombes, N., Mahyari, E., Hagen, S. I., Bae, J. Y., Reyes, M. D., Swanson, T., Legasse, A. W., Sylwester, A., Hansen, S., Smith, A. T., Stafova, P., Shoemaker, R., Li, Y., Oswald, K., Axthelm, M. & 8 others, McDermott, A., Ferrari, G., Montefiori, D. C., Edlefsen, P. T., Piatak, M., Lifson, J. D., Sékaly, R. P. & Picker, L., Nov 2012, In : Nature Medicine. 18, 11, p. 1673-1681 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
T-cells
Viruses
Vaccines
Lymph Nodes
2009
56 Citations (Scopus)

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M., Schmitz, J. E. & Picker, L., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

Lymphocyte Depletion
Simian Immunodeficiency Virus
T-Lymphocytes
Virus Diseases
Macaca mulatta
2005
44 Citations (Scopus)
Passive Immunization
Nasal Mucosa
Palatine Tonsil
Lymphoid Tissue
Streptococcus
11 Citations (Scopus)

The M protein is dispensable for maturation of streptococcal cysteine protease SpeB

Zimmerlein, B., Park, H., Li, S., Podbielski, A. & Cleary, P. P., Feb 2005, In : Infection and Immunity. 73, 2, p. 859-864 6 p.

Research output: Contribution to journalArticle

Cysteine Proteases
Streptococcus
Proteins
Membrane Proteins
Sequence Deletion
2004
6 Citations (Scopus)

Nasal associated lymphoid tissue & M cells, a window to persistent streptococcal infections

Cleary, P. P., Zhang, Y. & Park, H., 2004, In : Indian Journal of Medical Research, Supplement. 119, MAY, p. 57-60 4 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Lymphoid Tissue
Nose
Streptococcus
Tissue
26 Citations (Scopus)

Primary induction of CD4 T cell responses in nasal associated lymphoid tissue during group A streptococcal infection

Park, H., Costalonga, M., Reindhart, R. L., Dombek, P. E., Jenkins, M. K. & Cleary, P. P., Oct 2004, In : European Journal of Immunology. 34, 10, p. 2843-2853 11 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Lymphoid Tissue
Nose
T-Lymphocytes
Streptococcus
16 Citations (Scopus)

Promotion of fibronectin independent invasion by C5a peptidase into epithelial cells in group A Streptococcus

Purushothaman, S. S., Park, H. & Cleary, P. P., 2004, In : Indian Journal of Medical Research, Supplement. 119, MAY, p. 44-47 4 p.

Research output: Contribution to journalArticle

Streptococcus
Fibronectins
Epithelial Cells
Bacteria
Recombinant proteins
2003
105 Citations (Scopus)

Membranous cells in nasal-associated lymphoid tissue: A portal of entry for the respiratory mucosal pathogen group A streptococcus

Park, H., Francis, K. P., Yu, J. & Cleary, P. P., Sep 1 2003, In : Journal of Immunology. 171, 5, p. 2532-2537 6 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Streptococcus
Nose
Palatine Tonsil
Ulex
2002
40 Citations (Scopus)

Modification of type IV pilus-associated epithelial cell adherence and multicellular behavior by the PilU protein of Neisseria gonorrhoeae

Park, H., Wolfgang, M. & Koomey, M., 2002, In : Infection and Immunity. 70, 7, p. 3891-3903 13 p.

Research output: Contribution to journalArticle

Neisseria gonorrhoeae
Epithelial Cells
Adenosine Triphosphatases
Phenotype
Proteins
2001
29 Citations (Scopus)

Structural alterations in a type IV pilus subunit protein result in concurrent defects in multicellular behaviour and adherence to host tissue

Park, H., Wolfgang, M., Van Putten, J. P. M., Dorward, D., Hayes, S. F. & Koomey, M., 2001, In : Molecular Microbiology. 42, 2, p. 293-307 15 p.

Research output: Contribution to journalArticle

Protein Subunits
Aptitude
Alleles
Cell Aggregation
Neisseria gonorrhoeae
1998
247 Citations (Scopus)

PilT mutations lead to simultaneous defects in competence for natural transformation and twitching motility in piliated Neisseria gonorrhoeae

Wolfgang, M., Lauer, P., Park, H., Brossay, L., Hébert, J. & Koomey, M., 1998, In : Molecular Microbiology. 29, 1, p. 321-330 10 p.

Research output: Contribution to journalArticle

Neisseria gonorrhoeae
Mental Competency
Mutation
Aptitude
Gonorrhea
116 Citations (Scopus)
Neisseria gonorrhoeae
Organelle Biogenesis
Genetic Transformation
Mutation
Gonorrhea
1995
29 Citations (Scopus)

Expansion of mycobacterium-reactive γδ T cells by a subset of memory helper T cells

Vila, L. M., Haftel, H. M., Park, H., Lin, M. S., Romzek, N. C., Hanash, S. M. & Holoshitz, J., 1995, In : Infection and Immunity. 63, 4, p. 1211-1217 7 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Mycobacterium
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Antigens